Page last updated: 2024-11-01

nitroglycerin and Labor, Premature

nitroglycerin has been researched along with Labor, Premature in 39 studies

Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.

Research Excerpts

ExcerptRelevanceReference
"Although obstetric pulmonary edema is associated with extensive radiographic infiltrates and severe hypoxemia, resolution occurs rapidly in most patients, limiting the need for intensive care support."5.30Pulmonary edema in obstetric patients is rapidly resolved except in the presence of infection or of nitroglycerin tocolysis after open fetal surgery. ( Burlingame, JM; DiFederico, EM; Harrison, M; Kilpatrick, SJ; Matthay, MA, 1998)
"The mean time of pregnancy prolongation was 25 days in the nitroglycerin patch group, and 8 days in the magnesium sulfate and salbutamol sulfate group."5.10[Clinical effect and mechanism of nitroglycerin patch on arresting preterm labor]. ( Chen, X; Gu, H; Gu, Q; He, Q; Ning, H; Sha, J; Yang, Z, 2002)
"To evaluate the effectiveness of nitroglycerin as a uterine relaxant for preterm labour, fetal extraction at Caesarean section, external version, embryo transfer, cervical dilation for first trimester pregnancy termination, and primary dysmenorrhea."4.81Nitroglycerin as a uterine relaxant: a systematic review. ( Kung, R; Morgan, PJ; Tarshis, J, 2002)
"Management of preterm labor and prevention from preterm delivery in order to lower these risks have always been under serious concern."2.79Comparison between nitroglycerin dermal patch and nifedipine for treatment of preterm labor: a randomized clinical trial. ( Kashanian, M; Sheikhansari, N; Zamen, Z, 2014)
" Outcome parameters were (1) the effects on fetal and maternal heart frequency (FHF/MHF) and blood pressure, and (2) subjective experiences of adverse effects assessed by utilising a questionnaire."2.71Maternal and fetal side effects of tocolysis using transdermal nitroglycerin or intravenous fenoterol combined with magnesium sulfate. ( Gross, W; Kähler, C; Möller, A; Möller, U; Richter, S; Schleussner, E; Seewald, HJ, 2003)
"Women in threatened preterm labor with positive fetal fibronectin or ruptured membranes between 24 and 35 weeks' gestation were recruited and randomly assigned to either beta2 or GTN with rescue beta2 tocolysis if moderate-to-strong contractions persisted at 2 hours."2.71The Randomized Nitric Oxide Tocolysis Trial (RNOTT) for the treatment of preterm labor. ( Bisits, A; Cheung, K; Chung, T; Daniel, M; Giles, W; Gill, A; Jones, I; Knox, M; Kwek, K; Leung, TN; Madsen, G; Smith, R; Toohill, J; Tudehope, D; Yeo, G, 2004)
"Twenty-six consecutive patients with preterm labor were randomized to tocolytic treatment with transdermal glyceryl trinitrate (n=13) or intravenous albuterol (n=13)."2.69Corticotropin-releasing hormone: a biochemical predictor of preterm delivery in a pilot randomized trial of the treatment of preterm labor. ( Bisits, A; Giles, W; Madsen, G; McLean, M; O'Callaghan, S; Smith, R, 1998)
"Nitroglycerin was administered as a 100-microg bolus, then at a rate of 1- to 10-microg/kg/min."2.69Randomized comparison of intravenous nitroglycerin and magnesium sulfate for treatment of preterm labor. ( Chitkara, U; Cohen, SE; Druzin, ML; El-Sayed, YY; Holbrook, RH; Riley, ET, 1999)
"Two hundred forty-five women with preterm labor and intact membranes between 24 and 36 weeks' gestation were randomized to transdermal glyceryl trinitrate or intravenous ritodrine."2.69Glyceryl trinitrate and ritodrine in tocolysis: an international multicenter randomized study. GTN Preterm Labour Investigation Group. ( Black, RS; Campbell, S; Danti, L; Lees, CC; Lojacono, A; Tanzi, P; Thompson, C; White, IR, 1999)
"Nitroglycerine was the NO donor used in all these trials."2.41Nitric oxide donors for the treatment of preterm labour. ( Duckitt, K; Thornton, S, 2002)
"Twenty-five pregnant women who received GTN patches (Nitroderm TTS 10) with a dosage of 0."1.32Nitric oxide donors: effects on fetoplacental blood flow. ( Kähler, C; Möller, A; Schleussner, E; Seewald, HJ, 2004)
"Nitroglycerin was infused maternally over 30 minutes at 1."1.30Fetal and maternal hemodynamic and metabolic effects of maternal nitroglycerin infusions in sheep. ( Bootstaylor, BS; Heymann, MA; Parer, JT; Roman, C, 1997)
"Although obstetric pulmonary edema is associated with extensive radiographic infiltrates and severe hypoxemia, resolution occurs rapidly in most patients, limiting the need for intensive care support."1.30Pulmonary edema in obstetric patients is rapidly resolved except in the presence of infection or of nitroglycerin tocolysis after open fetal surgery. ( Burlingame, JM; DiFederico, EM; Harrison, M; Kilpatrick, SJ; Matthay, MA, 1998)

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's16 (41.03)18.2507
2000's17 (43.59)29.6817
2010's6 (15.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Conde-Agudelo, A1
Romero, R1
Duckitt, K2
Thornton, S2
O'Donovan, OP1
Dowswell, T1
Kashanian, M1
Zamen, Z1
Sheikhansari, N1
Smith, GN5
Guo, Y2
Wen, SW2
Walker, MC4
Xie, R1
Shaikh, S1
Shaikh, AH1
Akhter, S1
Isran, B1
Morgan, PJ1
Kung, R1
Tarshis, J1
Leszczyńska-Gorzelak, B3
Laskowska, M3
Marciniak, B3
Oleszczuk, J3
Schleussner, E2
Möller, A2
Gross, W1
Kähler, C2
Möller, U1
Richter, S1
Seewald, HJ2
Sławatyński, A1
Bustard, MA1
Ryan, G1
Seaward, G1
Saleniak, ME1
de Spirlet, M1
Treluyer, JM1
Chevret, S1
Rey, E1
Tournaire, M1
Cabrol, D1
Pons, G1
Wani, MP1
Barakzai, N1
Graham, I1
Doggrell, SA1
Bisits, A3
Madsen, G3
Knox, M2
Gill, A2
Smith, R3
Yeo, G1
Kwek, K1
Daniel, M1
Leung, TN1
Cheung, K1
Chung, T1
Jones, I1
Toohill, J1
Tudehope, D2
Giles, W3
Rogers, Y1
Iams, JD1
Ohlsson, A1
O'Brien, K1
Windrim, R1
Nassar, AH1
Usta, IM1
Wessén, A1
Elowsson, P1
Axemo, P1
Lindberg, B1
Lees, C2
Campbell, S3
Jauniaux, E1
Brown, R1
Ramsay, B1
Gibb, D1
Moncada, S1
Martin, JF1
Duley, L1
Elbourne, D1
Hendrickx, B1
Ottman, EH1
Gall, SA1
Black, RS2
Flint, S1
Rowlands, S1
Trudinger, B1
Visva-Lingam, S1
Bootstaylor, BS1
Roman, C1
Parer, JT1
Heymann, MA1
Fliegner, JR1
Gronow, M1
David, M1
Güngör, L1
Lichtenegger, W1
McLean, M1
O'Callaghan, S1
DiFederico, EM1
Burlingame, JM1
Kilpatrick, SJ1
Harrison, M1
Matthay, MA1
El-Sayed, YY1
Riley, ET1
Holbrook, RH1
Cohen, SE1
Chitkara, U1
Druzin, ML1
McGrath, MJ1
Lees, CC1
Lojacono, A1
Thompson, C1
Danti, L1
Tanzi, P1
White, IR1
Luzi, G1
Caserta, G1
Iammarino, G1
Clerici, G1
Di Renzo, GC1
He, Q1
Sha, J1
Gu, Q1
Gu, H1
Chen, X1
Yang, Z1
Ning, H1

Reviews

5 reviews available for nitroglycerin and Labor, Premature

ArticleYear
Transdermal nitroglycerin for the treatment of preterm labor: a systematic review and metaanalysis.
    American journal of obstetrics and gynecology, 2013, Volume: 209, Issue:6

    Topics: Administration, Cutaneous; Adrenergic beta-2 Receptor Agonists; Female; Humans; Magnesium Sulfate; N

2013
Nitric oxide donors for treating preterm labour.
    The Cochrane database of systematic reviews, 2014, May-08, Issue:5

    Topics: Female; Humans; Nitric Oxide Donors; Nitroglycerin; Obstetric Labor, Premature; Pregnancy; Randomize

2014
Nitric oxide donors for the treatment of preterm labour.
    The Cochrane database of systematic reviews, 2002, Issue:3

    Topics: Female; Humans; Nitric Oxide Donors; Nitroglycerin; Obstetric Labor, Premature; Pregnancy; Randomize

2002
Nitroglycerin as a uterine relaxant: a systematic review.
    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2002, Volume: 24, Issue:5

    Topics: Cesarean Section; Dysmenorrhea; Embryo Transfer; Female; Humans; Nitroglycerin; Obstetric Labor, Pre

2002
Recent pharmacological advances in the treatment of preterm membrane rupture, labour and delivery.
    Expert opinion on pharmacotherapy, 2004, Volume: 5, Issue:9

    Topics: Adrenergic beta-2 Receptor Agonists; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal;

2004

Trials

14 trials available for nitroglycerin and Labor, Premature

ArticleYear
Comparison between nitroglycerin dermal patch and nifedipine for treatment of preterm labor: a randomized clinical trial.
    Journal of perinatology : official journal of the California Perinatal Association, 2014, Volume: 34, Issue:9

    Topics: Apgar Score; Birth Weight; Cesarean Section; Female; Gestational Age; Humans; Infant, Newborn; Inten

2014
Secondary analysis of the use of transdermal nitroglycerin for preterm labor.
    American journal of obstetrics and gynecology, 2010, Volume: 203, Issue:6

    Topics: Administration, Cutaneous; Adult; Confidence Intervals; Delivery, Obstetric; Dose-Response Relations

2010
Maternal and fetal side effects of tocolysis using transdermal nitroglycerin or intravenous fenoterol combined with magnesium sulfate.
    European journal of obstetrics, gynecology, and reproductive biology, 2003, Jan-10, Volume: 106, Issue:1

    Topics: Administration, Cutaneous; Adolescent; Adult; Blood Pressure; Drug Therapy, Combination; Female; Fen

2003
Tocolytic effects of intravenous nitroglycerin.
    Fundamental & clinical pharmacology, 2004, Volume: 18, Issue:2

    Topics: Adult; Clinical Protocols; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fetal Bloo

2004
Glyceryl trinitrate vs. ritodrine for the treatment of preterm labor.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2004, Volume: 85, Issue:2

    Topics: Administration, Cutaneous; Female; Humans; Infusions, Intravenous; Nitroglycerin; Obstetric Labor, P

2004
The Randomized Nitric Oxide Tocolysis Trial (RNOTT) for the treatment of preterm labor.
    American journal of obstetrics and gynecology, 2004, Volume: 191, Issue:3

    Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Adult; Delivery, Obstetric; Female; G

2004
Neonatal neurodevelopmental outcomes following tocolysis with glycerol trinitrate patches.
    American journal of obstetrics and gynecology, 2006, Volume: 195, Issue:2

    Topics: Adrenergic beta-Agonists; Albuterol; Child Development; Female; Humans; Infant; Intelligence; Nitrog

2006
Randomized double-blind placebo-controlled trial of transdermal nitroglycerin for preterm labor.
    American journal of obstetrics and gynecology, 2007, Volume: 196, Issue:1

    Topics: Administration, Cutaneous; Adult; Double-Blind Method; Female; Humans; Infant, Newborn; Infant, Newb

2007
Corticotropin-releasing hormone: a biochemical predictor of preterm delivery in a pilot randomized trial of the treatment of preterm labor.
    American journal of obstetrics and gynecology, 1998, Volume: 178, Issue:4

    Topics: Administration, Cutaneous; Adult; Albuterol; Corticotropin-Releasing Hormone; Female; Gestational Ag

1998
Randomized comparison of intravenous nitroglycerin and magnesium sulfate for treatment of preterm labor.
    Obstetrics and gynecology, 1999, Volume: 93, Issue:1

    Topics: Adult; Blood Pressure; Female; Heart Rate; Humans; Injections, Intravenous; Magnesium Sulfate; Nitro

1999
Randomised, double-blind, placebo controlled pilot study assessing nitroglycerin as a tocolytic.
    British journal of obstetrics and gynaecology, 1999, Volume: 106, Issue:7

    Topics: Administration, Cutaneous; Adult; Double-Blind Method; Female; Humans; Nitroglycerin; Obstetric Labo

1999
Glyceryl trinitrate and ritodrine in tocolysis: an international multicenter randomized study. GTN Preterm Labour Investigation Group.
    Obstetrics and gynecology, 1999, Volume: 94, Issue:3

    Topics: Adolescent; Adult; Female; Humans; Nitroglycerin; Obstetric Labor, Premature; Pregnancy; Ritodrine;

1999
Nitric oxide for treatment of threatened preterm labor.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2001, Volume: 73, Issue:3

    Topics: Administration, Cutaneous; Cardiotocography; Drug Monitoring; Female; Gestational Age; Humans; Nitri

2001
[Clinical effect and mechanism of nitroglycerin patch on arresting preterm labor].
    Zhonghua fu chan ke za zhi, 2002, Volume: 37, Issue:3

    Topics: Adult; Albuterol; Corticotropin-Releasing Hormone; Drug Therapy, Combination; Female; Humans; Magnes

2002

Other Studies

20 other studies available for nitroglycerin and Labor, Premature

ArticleYear
Maternal transdermal nitroglycerin use and early childhood development.
    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2010, Volume: 32, Issue:12

    Topics: Administration, Cutaneous; Canada; Child Development; Child, Preschool; Female; Follow-Up Studies; H

2010
Efficacy of transdermal nitroglycerine in idiopathic pre-term labour.
    JPMA. The Journal of the Pakistan Medical Association, 2012, Volume: 62, Issue:1

    Topics: Administration, Cutaneous; Adult; Female; Gestational Age; Humans; Infant, Newborn; Male; Nitroglyce

2012
[The use of nitroglycerin as nitric oxide donor for treatment of preterm labour].
    Ginekologia polska, 2002, Volume: 73, Issue:8

    Topics: Administration, Cutaneous; Adult; Female; Humans; Hypertension; Nitric Oxide Donors; Nitroglycerin;

2002
[The influence of transdermal nitroglycerin patches on fetal blood flow parameters in threatened preterm labor].
    Ginekologia polska, 2002, Volume: 73, Issue:9

    Topics: Administration, Cutaneous; Adult; Blood Flow Velocity; Female; Fetus; Humans; Nitroglycerin; Obstetr

2002
Human maternal and fetal plasma glyceryl trinitrate concentrations.
    American journal of obstetrics and gynecology, 2003, Volume: 189, Issue:6

    Topics: Administration, Cutaneous; Biological Availability; Female; Fetal Blood; Gestational Age; Humans; Ma

2003
Nitric oxide donors: effects on fetoplacental blood flow.
    European journal of obstetrics, gynecology, and reproductive biology, 2004, Jul-15, Volume: 115, Issue:1

    Topics: Arteries; Female; Fetus; Gestational Age; Humans; Nitric Oxide Donors; Nitroglycerin; Obstetric Labo

2004
Transdermal nitroglycerin for preterm labor.
    American journal of obstetrics and gynecology, 2007, Volume: 196, Issue:1

    Topics: Administration, Cutaneous; Female; Humans; Nitroglycerin; Obstetric Labor, Premature; Pregnancy; Toc

2007
Randomized, double-blind, placebo-controlled trial of transdermal nitroglycerin for preterm labor.
    American journal of obstetrics and gynecology, 2007, Volume: 197, Issue:3

    Topics: Administration, Cutaneous; Double-Blind Method; Female; Gestational Age; Humans; Nitroglycerin; Obst

2007
The use of intravenous nitroglycerin for emergency cervico-uterine relaxation.
    Acta anaesthesiologica Scandinavica, 1995, Volume: 39, Issue:6

    Topics: Adult; Anesthesia, General; Anesthesia, Obstetrical; Cervix Uteri; Emergencies; Female; Humans; Inje

1995
Arrest of preterm labour and prolongation of gestation with glyceryl trinitrate, a nitric oxide donor.
    Lancet (London, England), 1994, May-28, Volume: 343, Issue:8909

    Topics: Administration, Cutaneous; Female; Humans; Nitroglycerin; Obstetric Labor, Premature; Pregnancy; Ute

1994
Glyceryl trinitrate in management of preterm labour.
    Lancet (London, England), 1994, Aug-20, Volume: 344, Issue:8921

    Topics: Administration, Cutaneous; Female; Humans; Nitroglycerin; Obstetric Labor, Premature; Pregnancy; Toc

1994
Glyceryl trinitrate in management of preterm labour.
    Lancet (London, England), 1994, Aug-20, Volume: 344, Issue:8921

    Topics: Administration, Cutaneous; Female; Humans; Nitroglycerin; Obstetric Labor, Premature; Pregnancy; Toc

1994
Myocardial infarction in the third trimester of pregnancy secondary to an aortic valve thrombus.
    Obstetrics and gynecology, 1993, Volume: 81, Issue:5 ( Pt 2)

    Topics: Adult; Aortic Valve; Female; Heart Valve Prosthesis; Heparin; Humans; Myocardial Infarction; Nifedip

1993
Preterm labour and delivery.
    European journal of pediatrics, 1996, Volume: 155 Suppl 2

    Topics: Adrenergic beta-Agonists; Biomarkers; Female; Humans; Indomethacin; Magnesium; Nitroglycerin; Obstet

1996
Treatment of preterm cervical dilatation with glyceryl trinitrate, a nitric oxide donor.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1996, Volume: 36, Issue:4

    Topics: Administration, Cutaneous; Adult; Female; Humans; Labor Stage, First; Nitroglycerin; Obstetric Labor

1996
Fetal and maternal hemodynamic and metabolic effects of maternal nitroglycerin infusions in sheep.
    American journal of obstetrics and gynecology, 1997, Volume: 176, Issue:3

    Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Fetus; Glucose; Heart Rate; Hemod

1997
Treatment of pre-term cervical dilatation with glyceryl trinitrate, a nitric oxide donor.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1997, Volume: 37, Issue:4

    Topics: Female; Humans; Nitroglycerin; Obstetric Labor, Premature; Pregnancy; Tocolytic Agents; Vasodilator

1997
[Tocolysis with a nitroglycerin patch].
    Zentralblatt fur Gynakologie, 1998, Volume: 120, Issue:3

    Topics: Administration, Cutaneous; Adult; Female; Fenoterol; Humans; Infant, Newborn; Nitroglycerin; Obstetr

1998
Pulmonary edema in obstetric patients is rapidly resolved except in the presence of infection or of nitroglycerin tocolysis after open fetal surgery.
    American journal of obstetrics and gynecology, 1998, Volume: 179, Issue:4

    Topics: Critical Care; Female; Fetus; Hemodynamics; Humans; Lung; Nitroglycerin; Obstetric Labor, Premature;

1998
Nitric oxide donors in pregnancy: fetomaternal hemodynamic effects induced in mild pre-eclampsia and threatened preterm labor.
    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 1999, Volume: 14, Issue:2

    Topics: Blood Flow Velocity; Blood Pressure; Female; Gestational Age; Heart Rate, Fetal; Hemodynamics; Human

1999