nitroglycerin has been researched along with Ischemic Stroke in 6 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Ischemic Stroke: Stroke due to BRAIN ISCHEMIA resulting in interruption or reduction of blood flow to a part of the brain. When obstruction is due to a BLOOD CLOT formed within in a cerebral blood vessel it is a thrombotic stroke. When obstruction is formed elsewhere and moved to block a cerebral blood vessel (see CEREBRAL EMBOLISM) it is referred to as embolic stroke. Wake-up stroke refers to ischemic stroke occurring during sleep while cryptogenic stroke refers to ischemic stroke of unknown origin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The study was conducted to test the hypothesis that nitroglycerin (NTG) increases cerebral perfusion focally and globally in acute ischemic stroke patients, using serial perfusion-weighted imaging (PWI) magnetic resonance imaging measurements." | 8.02 | Nitroglycerin Is Not Associated with Improved Cerebral Perfusion in Acute Ischemic Stroke. ( Asdaghi, N; Beaulieu, C; Buck, B; Butcher, K; Emery, D; Gioia, L; Jeerakathil, T; Kate, M; Shuaib, A, 2021) |
| "Pooled analyses of previous randomised studies have suggested that very early treatment with glyceryl trinitrate (also known as nitroglycerin) improves functional outcome in patients with acute ischaemic stroke or intracerebral haemorrhage, but this finding was not confirmed in a more recent trial (RIGHT-2)." | 5.51 | Prehospital transdermal glyceryl trinitrate in patients with presumed acute stroke (MR ASAP): an ambulance-based, multicentre, randomised, open-label, blinded endpoint, phase 3 trial. ( Berkhemer, OA; Boomars, R; Boomsma, JMF; Caminada, K; de Leeuw, FE; Dippel, DWJ; Emmer, BJ; Esteve Cuevas, LM; Fransen, PSS; Hofmeijer, J; Kerkhoff, H; Kwa, VIH; Lingsma, HF; Lok, T; Majoie, CBLM; Miedema, I; Nederkoorn, PJ; Nieboer, D; O Pruissen, DM; Raaijmakers, TWM; Reinink, H; Roos, YBWEM; Schipper, MH; Schonewille, WJ; Siegers, A; Uniken Venema, SM; van 't Net, A; van den Berg, SA; van der Lugt, A; van der Worp, HB; van Dijk, GW; van Eijkelenburg, RPJ; van Oostenbrugge, RJ; van Vliet, JA; Visser, MC; Zwetsloot, CP, 2022) |
| "The study was conducted to test the hypothesis that nitroglycerin (NTG) increases cerebral perfusion focally and globally in acute ischemic stroke patients, using serial perfusion-weighted imaging (PWI) magnetic resonance imaging measurements." | 4.02 | Nitroglycerin Is Not Associated with Improved Cerebral Perfusion in Acute Ischemic Stroke. ( Asdaghi, N; Beaulieu, C; Buck, B; Butcher, K; Emery, D; Gioia, L; Jeerakathil, T; Kate, M; Shuaib, A, 2021) |
| " GTN appears safe in ipsilateral or bilateral carotid stenosis, and might improve outcome in severe ipsilateral carotid stenosis." | 2.90 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis. ( Appleton, JP; Bath, PM; Belcher, A; Bereczki, D; Berge, E; Caso, V; Chang, HM; Christensen, HK; Collins, R; Gommans, J; Laska, AC; Ntaios, G; Ozturk, S; Sare, GM; Sprigg, N; Szatmari, S; Wang, Y; Wardlaw, JM; Woodhouse, LJ, 2019) |
| " Safety outcomes were adverse events." | 2.82 | Benefits and safety of transdermal glyceryl trinitrate in acute stroke: A systematic review and meta-analysis of randomized trials. ( Chan, WL; Lee, WF; Lim, BL; Loo, KV; Man Goh, CJ; Ng, WM; Situ, W, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 5 (83.33) | 2.80 |
| Authors | Studies |
|---|---|
| Lim, BL | 1 |
| Lee, WF | 1 |
| Ng, WM | 1 |
| Situ, W | 1 |
| Loo, KV | 1 |
| Man Goh, CJ | 1 |
| Chan, WL | 1 |
| van den Berg, SA | 1 |
| Uniken Venema, SM | 1 |
| Reinink, H | 1 |
| Hofmeijer, J | 1 |
| Schonewille, WJ | 1 |
| Miedema, I | 1 |
| Fransen, PSS | 1 |
| O Pruissen, DM | 1 |
| Raaijmakers, TWM | 1 |
| van Dijk, GW | 1 |
| de Leeuw, FE | 1 |
| van Vliet, JA | 1 |
| Kwa, VIH | 1 |
| Kerkhoff, H | 1 |
| van 't Net, A | 1 |
| Boomars, R | 1 |
| Siegers, A | 1 |
| Lok, T | 1 |
| Caminada, K | 1 |
| Esteve Cuevas, LM | 1 |
| Visser, MC | 1 |
| Zwetsloot, CP | 1 |
| Boomsma, JMF | 1 |
| Schipper, MH | 1 |
| van Eijkelenburg, RPJ | 1 |
| Berkhemer, OA | 1 |
| Nieboer, D | 1 |
| Lingsma, HF | 1 |
| Emmer, BJ | 1 |
| van Oostenbrugge, RJ | 1 |
| van der Lugt, A | 1 |
| Roos, YBWEM | 1 |
| Majoie, CBLM | 1 |
| Dippel, DWJ | 1 |
| Nederkoorn, PJ | 1 |
| van der Worp, HB | 1 |
| Gao, J | 1 |
| Cheng, Z | 1 |
| Jiang, S | 1 |
| Wills, M | 1 |
| Wehbe, A | 1 |
| Rajah, GB | 1 |
| Geng, X | 1 |
| Ding, Y | 1 |
| Kate, M | 1 |
| Gioia, L | 1 |
| Asdaghi, N | 1 |
| Jeerakathil, T | 1 |
| Shuaib, A | 1 |
| Buck, B | 1 |
| Emery, D | 1 |
| Beaulieu, C | 1 |
| Butcher, K | 1 |
| Sorby-Adams, AJ | 1 |
| Learoyd, AE | 1 |
| Bath, PM | 2 |
| Burrows, F | 1 |
| Farr, TD | 1 |
| Leonard, AV | 1 |
| Schiessl, I | 1 |
| Allan, SM | 1 |
| Turner, RJ | 1 |
| Trueman, RC | 1 |
| Appleton, JP | 1 |
| Woodhouse, LJ | 1 |
| Belcher, A | 1 |
| Bereczki, D | 1 |
| Berge, E | 1 |
| Caso, V | 1 |
| Chang, HM | 1 |
| Christensen, HK | 1 |
| Collins, R | 1 |
| Gommans, J | 1 |
| Laska, AC | 1 |
| Ntaios, G | 1 |
| Ozturk, S | 1 |
| Sare, GM | 1 |
| Szatmari, S | 1 |
| Wang, Y | 1 |
| Wardlaw, JM | 1 |
| Sprigg, N | 1 |
1 review available for nitroglycerin and Ischemic Stroke
| Article | Year |
|---|---|
Benefits and safety of transdermal glyceryl trinitrate in acute stroke: A systematic review and meta-analysis of randomized trials.
Topics: Cerebral Hemorrhage; Humans; Ischemic Stroke; Nitroglycerin; Randomized Controlled Trials as Topic; | 2022 |
3 trials available for nitroglycerin and Ischemic Stroke
| Article | Year |
|---|---|
Prehospital transdermal glyceryl trinitrate in patients with presumed acute stroke (MR ASAP): an ambulance-based, multicentre, randomised, open-label, blinded endpoint, phase 3 trial.
Topics: Adolescent; Adult; Ambulances; Brain Ischemia; Cerebral Hemorrhage; Humans; Ischemic Attack, Transie | 2022 |
Arterial Glyceryl Trinitrate in Acute Ischemic Stroke after Thrombectomy for Neuroprotection (AGAIN): Rationale, design and protocol for a prospective randomized controlled trial.
Topics: Brain Ischemia; Humans; Ischemic Stroke; Neuroprotection; Nitrates; Nitric Oxide; Nitroglycerin; Pil | 2022 |
It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis.
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Carotid | 2019 |
2 other studies available for nitroglycerin and Ischemic Stroke
| Article | Year |
|---|---|
Nitroglycerin Is Not Associated with Improved Cerebral Perfusion in Acute Ischemic Stroke.
Topics: Brain Ischemia; Cerebrovascular Circulation; Humans; Ischemic Stroke; Nitroglycerin; Perfusion; Stro | 2021 |
Glyceryl trinitrate for the treatment of ischaemic stroke: Determining efficacy in rodent and ovine species for enhanced clinical translation.
Topics: Animals; Cerebrovascular Circulation; Female; Ischemic Stroke; Male; Mice; Nitroglycerin; Sheep | 2021 |