nitroglycerin has been researched along with Intracranial Aneurysm in 26 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Intracranial Aneurysm: Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (
| Excerpt | Relevance | Reference |
|---|---|---|
| "The cardiovascular effects of nitroglycerine (TNG) were studied in 30 patients requiring controlled hypotension for intracranial aneurysm surgery." | 3.67 | Use of nitroglycerine to produce controlled decreases in mean arterial pressure to less than 50 mm Hg. ( Dagreou, F; Gallais, S; Guggiari, M; Lienhart, A; Mottet, P; Philippon, J; Viars, P, 1985) |
| "Deliberate hypotension was induced by using nitroglycerin (NG) during anesthesia in 13 patients with intracranial aneurysm, who underwent clipping surgery." | 3.67 | [Clinical study on hypotensive anesthesia with nitroglycerin]. ( Kadoya, T; Kurokawa, M; Ogata, M; Takara, H; Tanaka, T, 1985) |
| "In the case of hypertensive encephalopathy, the lowering of blood pressure is therapeutic as well as diagnostic." | 2.43 | [Antihypertensive management in acute cerebral stroke]. ( Ziliene, V, 2005) |
| "Delayed cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) is a major cause of high morbidity and mortality." | 1.37 | Continuous intrathecal glyceryl trinitrate prevents delayed cerebral vasospasm in the single-SAH rabbit model in vivo. ( Fandino, J; Fathi, AR; Graupner, T; Jakob, SM; Marbacher, S; Schroth, G; Wehrli, F, 2011) |
| "The effects of intravenous nitroglycerin (NTG) combined with dopamine on intracranial pressure (ICP) and cerebral arteriovenous oxygen difference (AVDO2) were studied in 11 patients with acute subarachnoid haemorrhage (SAH)." | 1.29 | Effects of intravenous nitroglycerin combined with dopamine on intracranial pressure and cerebral arteriovenous oxygen difference in patients with acute subarachnoid haemorrhage. ( Aoki, H; Boku, E; Goda, K; Imanishi, M; Iwanaga, H; Koshimae, N; Okuchi, K; Sakaki, T; Tokunaga, H, 1995) |
| "Especially in patients with severe subarachnoid hemorrhage classified as CT group 3 or 4, symptomatic vasospasm occurred in 11 patients (30." | 1.28 | [Clinical effect of nitroglycerin (GTN) on prevention of cerebral vasospasm]. ( Goto, T; Ogayama, H; Sasaki, J; Sasanuma, J; Watanabe, K, 1991) |
| "29 patients were operated on cerebral aneurysms and arterio-venous malformations in hypotension induced by sodium nitroprusside, nitroglycerin or a combination of the two substances." | 1.26 | [Postoperative reactions of blood pressure after neurosurgical operations in deliberate hypotension (author's transl)]. ( Kirchner, E; Spring, A; Spring, G, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (65.38) | 18.7374 |
| 1990's | 4 (15.38) | 18.2507 |
| 2000's | 4 (15.38) | 29.6817 |
| 2010's | 1 (3.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mikulandra, S | 1 |
| Hirs, I | 1 |
| Deutsch, J | 1 |
| Fathi, AR | 1 |
| Marbacher, S | 1 |
| Graupner, T | 1 |
| Wehrli, F | 1 |
| Jakob, SM | 1 |
| Schroth, G | 1 |
| Fandino, J | 1 |
| Ogawa-Okamoto, C | 1 |
| Saito, S | 1 |
| Nishihara, F | 1 |
| Yuki, N | 1 |
| Goto, F | 1 |
| Ziliene, V | 1 |
| Pluta, RM | 1 |
| Di Giugno, G | 2 |
| Rosa, G | 2 |
| Orfei, P | 2 |
| Bellerino, O | 1 |
| Lamur, M | 1 |
| Blanchet, P | 1 |
| Boularan, A | 1 |
| Buxeda, M | 1 |
| Dabbach, E | 1 |
| Roquefeuil, B | 1 |
| Artru, F | 1 |
| Philippon, B | 1 |
| Poussel, JF | 1 |
| Montarry, M | 1 |
| Deleuze, R | 1 |
| Murakawa, T | 2 |
| Yamashita, M | 2 |
| Satone, T | 1 |
| Kudo, M | 2 |
| Matsuki, A | 2 |
| Oyama, T | 2 |
| Spring, A | 1 |
| Spring, G | 1 |
| Kirchner, E | 1 |
| Farelli, S | 2 |
| Mazzone, P | 2 |
| Robbiano, F | 1 |
| Lagerkranser, M | 1 |
| Iwanaga, H | 2 |
| Okuchi, K | 1 |
| Koshimae, N | 1 |
| Goda, K | 1 |
| Imanishi, M | 1 |
| Tokunaga, H | 1 |
| Aoki, H | 1 |
| Boku, E | 1 |
| Sakaki, T | 1 |
| Sahin, A | 1 |
| Erçelen, O | 1 |
| Aypar, U | 1 |
| Erbengi, A | 1 |
| Cuadrado Mounir, LF | 1 |
| Abou-Madi Bruno, MN | 1 |
| Domb, B | 1 |
| Barnes, J | 1 |
| Trop, D | 1 |
| Abe, K | 1 |
| Yoshiya, I | 1 |
| Sasanuma, J | 1 |
| Goto, T | 1 |
| Ogayama, H | 1 |
| Sasaki, J | 1 |
| Watanabe, K | 1 |
| Tanaka, S | 1 |
| Maeyama, R | 1 |
| Kawahara, K | 1 |
| Arimura, H | 1 |
| Fukuda, A | 1 |
| Toyota, Y | 1 |
| Maktabi, M | 1 |
| Warner, D | 1 |
| Sokoll, M | 1 |
| Boarini, D | 1 |
| Adolphson, A | 1 |
| Speed, T | 1 |
| Kassell, N | 1 |
| Fasano, VA | 1 |
| Urciuoli, R | 1 |
| Bolognese, P | 1 |
| Mostert, M | 1 |
| Guggiari, M | 1 |
| Dagreou, F | 1 |
| Lienhart, A | 1 |
| Gallais, S | 1 |
| Mottet, P | 1 |
| Philippon, J | 1 |
| Viars, P | 1 |
| Wakayama, S | 1 |
| Ryba, M | 1 |
| Johansson, K | 1 |
| Cybulska, A | 1 |
| Kurokawa, M | 1 |
| Ogata, M | 1 |
| Takara, H | 1 |
| Kadoya, T | 1 |
| Tanaka, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Systemic Nitrosative/Oxidative Stress in Patients With Acute Brain Injury[NCT04951453] | 150 participants (Actual) | Observational | 2021-08-18 | Active, not recruiting | |||
| Cerebral Nitrosative/Oxidative Stress in Aneurysmal Subarachnoid Haemorrhage[NCT05686265] | 32 participants (Anticipated) | Observational | 2023-05-11 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for nitroglycerin and Intracranial Aneurysm
| Article | Year |
|---|---|
[Antihypertensive management in acute cerebral stroke].
Topics: Acute Disease; Adult; Antihypertensive Agents; Brain Injuries; Cerebrovascular Circulation; Emergenc | 2005 |
Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH.
Topics: Humans; Intracranial Aneurysm; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxid | 2008 |
Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH.
Topics: Humans; Intracranial Aneurysm; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxid | 2008 |
Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH.
Topics: Humans; Intracranial Aneurysm; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxid | 2008 |
Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH.
Topics: Humans; Intracranial Aneurysm; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxid | 2008 |
3 trials available for nitroglycerin and Intracranial Aneurysm
| Article | Year |
|---|---|
[Preliminary report in the use of nitroglycerin as a hypotensive agent in neurosurgery].
Topics: Adolescent; Adult; Antihypertensive Agents; Clinical Trials as Topic; Drug Evaluation; Female; Heart | 1979 |
Carbon dioxide reactivity and local cerebral blood flow during prostaglandin E1- or nitroglycerin-induced hypotension.
Topics: Adult; Aged; Alprostadil; Anesthesia, Inhalation; Blood Pressure; Carbon Dioxide; Cerebrovascular Ci | 1992 |
[Controlled hypotension with sodium nitroprusside or trinitroglycerin in intracranial vascular surgery].
Topics: Adolescent; Adult; Blood Pressure; Female; Ferricyanides; Humans; Hypotension, Controlled; Intracran | 1987 |
21 other studies available for nitroglycerin and Intracranial Aneurysm
| Article | Year |
|---|---|
Unusual use of nitroglycerin for severe bronchospasm during coiling embolization of ruptured intracranial aneurysm.
Topics: Adult; Algorithms; Aneurysm, Ruptured; Bronchial Spasm; Embolization, Therapeutic; Humans; Intracran | 2008 |
Continuous intrathecal glyceryl trinitrate prevents delayed cerebral vasospasm in the single-SAH rabbit model in vivo.
Topics: Animals; Disease Models, Animal; Injections, Spinal; Intracranial Aneurysm; Male; Nitroglycerin; Rab | 2011 |
Blood pressure control with glyceryl trinitrate during electroconvulsive therapy in a patient with cerebral aneurysm.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Electroconvulsive Therapy; Female; Humans; Hypertensi | 2003 |
[Controlled hypotension in the surgery of intracranial arterial aneurysms. Comparison of sodium nitroprusside, trimethaphan and trinitroglycerin].
Topics: Adult; Aged; Anesthesia, General; Ferricyanides; Humans; Hypotension, Controlled; Intracranial Aneur | 1983 |
[Controlled hypotension in the surgery of intracranial arterial aneurysms].
Topics: Adult; Aged; Humans; Hypotension, Controlled; Intracranial Aneurysm; Middle Aged; Neuroleptanalgesia | 1984 |
[Effects of intravenous nitroglycerin on blood pressure, intracranial pressure and total and regional cerebral blood flow in cases of subarachnoid hemorrhage with vasospasm].
Topics: Blood Pressure; Cerebrovascular Circulation; Humans; Intracranial Aneurysm; Intracranial Pressure; I | 1984 |
[Effect of nitroglycerin-induced hypotension on pituitary-adrenocortical function].
Topics: Female; Halothane; Humans; Hypothermia, Induced; Infusions, Parenteral; Intracranial Aneurysm; Male; | 1984 |
[Postoperative reactions of blood pressure after neurosurgical operations in deliberate hypotension (author's transl)].
Topics: Adolescent; Adult; Aged; Blood Pressure; Drug Interactions; Female; Ferricyanides; Heart Rate; Human | 1980 |
[Controlled hypotension in the neurosurgical treatment of intracranial aneurysm. Comparison of trimethaphan and nitroglycerin].
Topics: Adult; Aged; Female; Humans; Hypotension, Controlled; Intracranial Aneurysm; Male; Middle Aged; Nitr | 1982 |
Cardiovascular effects of nitroglycerin as a hypotensive agent in cerebral aneurysm surgery.
Topics: Adult; Blood Pressure; Cardiac Output; Female; Hemodynamics; Humans; Hypotension, Controlled; Intrac | 1982 |
Effects of intravenous nitroglycerin combined with dopamine on intracranial pressure and cerebral arteriovenous oxygen difference in patients with acute subarachnoid haemorrhage.
Topics: Adult; Aged; Brain; Dopamine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; H | 1995 |
Cerebral aneurysm surgery in a patient with phaeochromocytoma.
Topics: Adrenal Gland Neoplasms; Anesthetics, Inhalation; Anesthetics, Intravenous; Antihypertensive Agents; | 1998 |
[Clinical effect of nitroglycerin (GTN) on prevention of cerebral vasospasm].
Topics: Adult; Aged; Aged, 80 and over; Drug Evaluation; Female; Humans; Intracranial Aneurysm; Ischemic Att | 1991 |
[Ruptured aneurysm during pregnancy. Case report].
Topics: Adult; Female; Fetal Monitoring; Heart Rate, Fetal; Humans; Hypotension, Controlled; Intracranial An | 1987 |
Comparison of nitroprusside, nitroglycerin, and deep isoflurane anesthesia for induced hypotension.
Topics: Blood Pressure; Ferricyanides; Hemodynamics; Humans; Hypotension, Controlled; Intracranial Aneurysm; | 1986 |
[Controlled hypotension by using nitroglycerin and neurologic results. Computer analysis of 50 cases operated on for intracranial aneurysm].
Topics: Adult; Blood Pressure; Female; Humans; Hypotension, Controlled; Intracranial Aneurysm; Male; Middle | 1987 |
Intraoperative use of laser Doppler in the study of cerebral microvascular circulation.
Topics: Adult; Brain; Brain Neoplasms; Cerebrovascular Circulation; Female; Humans; Intracranial Aneurysm; M | 1988 |
Use of nitroglycerine to produce controlled decreases in mean arterial pressure to less than 50 mm Hg.
Topics: Adult; Anesthesia, General; Blood Pressure; Female; Hemodynamics; Humans; Hypotension, Controlled; I | 1985 |
[Effect of nitroglycerin-induced hypotension on plasma human growth hormone and insulin levels].
Topics: Blood Glucose; Female; Growth Hormone; Humans; Hypotension, Controlled; Insulin; Intracranial Aneury | 1985 |
Brain metabolism in deep controlled hypotension in neurosurgical patients.
Topics: Adult; Brain; Female; Humans; Hypotension, Controlled; Intracranial Aneurysm; L-Lactate Dehydrogenas | 1985 |
[Clinical study on hypotensive anesthesia with nitroglycerin].
Topics: Adult; Anesthesia, Intravenous; Female; Heart Rate; Humans; Hypotension, Controlled; Intracranial An | 1985 |