nitroglycerin has been researched along with Hemorrhoids in 22 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Hemorrhoids: Swollen veins in the lower part of the RECTUM or ANUS. Hemorrhoids can be inside the anus (internal), under the skin around the anus (external), or protruding from inside to outside of the anus. People with hemorrhoids may or may not exhibit symptoms which include bleeding, itching, and pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Besides an anal fissure in the past, which responded to nitroglycerin ointment, his medical history was unremarkable." | 4.31 | Causes and Management of Pruritus Ani. ( Beresneva, O; Sacks, OA, 2023) |
| " This report documents a therapeutic role for nitroglycerin, a nitric oxide donor, in the treatment of acutely thrombosed external hemorrhoids and anal fissure." | 3.69 | Treatment of benign anal disease with topical nitroglycerin. ( Gorfine, SR, 1995) |
| "Overall analysis of postoperative pain at rest showed a significant reduction in the botulinum toxin group vs." | 2.72 | Botulinum toxin vs. topical glyceryl trinitrate ointment for pain control in patients undergoing hemorrhoidectomy: a randomized trial. ( Almasio, PL; Arcara, M; Calogero, F; Di Vita, G; Fede, C; Gaetano, DV; Luigi, AP; Matteo, A; Patti, R; Pietro, R; Romano, P; Sammartano, S; Sergio, S, 2006) |
| "Hemorrhoidectomy is associated with postoperative pain and prolonged wound healing." | 2.53 | Effect of Glyceryl Trinitrate Ointment on Pain Control After Hemorrhoidectomy: A Meta-analysis of Randomized Controlled Trials. ( Kiu, KT; Lin, CC; Liu, JW; Tam, KW; Wang, CY, 2016) |
| "The side effect of headache has often been an associated problem." | 2.46 | Meta-analysis of the use of glyceryl trinitrate ointment after haemorrhoidectomy as an analgesic and in promoting wound healing. ( Andreani, SM; Light, D; Patel, B; Ratnasingham, K; Uzzaman, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 11 (50.00) | 29.6817 |
| 2010's | 8 (36.36) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Sacks, OA | 2 |
| Beresneva, O | 2 |
| Mari, FS | 1 |
| Nigri, G | 1 |
| Dall'Oglio, A | 1 |
| Cosenza, UM | 1 |
| Milillo, A | 1 |
| Terrenato, I | 1 |
| Pancaldi, A | 1 |
| Brescia, A | 1 |
| Khan, KI | 1 |
| Waqas, A | 1 |
| Akmal, M | 1 |
| Mahmood, S | 1 |
| Iqbal, A | 1 |
| Liu, JW | 1 |
| Lin, CC | 1 |
| Kiu, KT | 1 |
| Wang, CY | 1 |
| Tam, KW | 1 |
| Karanlik, H | 1 |
| Akturk, R | 1 |
| Camlica, H | 1 |
| Asoglu, O | 1 |
| Ratnasingham, K | 1 |
| Uzzaman, M | 1 |
| Andreani, SM | 1 |
| Light, D | 1 |
| Patel, B | 1 |
| Siddiqui, MR | 2 |
| Daulatzai, N | 1 |
| Abraham-Igwe, C | 1 |
| Shangumanandan, A | 1 |
| Grassi, V | 1 |
| Swift, I | 1 |
| Abulafi, AM | 1 |
| Krammer, H | 1 |
| Herold, A | 1 |
| Franceschilli, L | 1 |
| D'Ugo, S | 1 |
| de Luca, E | 1 |
| Cadeddu, F | 1 |
| Milito, G | 1 |
| di Lorenzo, N | 1 |
| Gaspari, AL | 1 |
| Sileri, P | 1 |
| Elton, C | 1 |
| Sen, P | 1 |
| Montgomery, AC | 1 |
| Hwang, DY | 1 |
| Yoon, SG | 1 |
| Kim, HS | 1 |
| Lee, JK | 1 |
| Kim, KY | 1 |
| Patti, R | 1 |
| Almasio, PL | 1 |
| Luigi, AP | 1 |
| Arcara, M | 1 |
| Matteo, A | 1 |
| Sammartano, S | 1 |
| Sergio, S | 1 |
| Romano, P | 1 |
| Pietro, R | 1 |
| Fede, C | 1 |
| Calogero, F | 1 |
| Di Vita, G | 1 |
| Gaetano, DV | 1 |
| Tan, KY | 1 |
| Sng, KK | 1 |
| Tay, KH | 1 |
| Lai, JH | 1 |
| Eu, KW | 1 |
| Tjandra, JJ | 1 |
| Tan, JJ | 1 |
| Lim, JF | 1 |
| Murray-Green, C | 1 |
| Kennedy, ML | 1 |
| Lubowski, DZ | 1 |
| Nash, G | 1 |
| Gorfine, SR | 1 |
| Mathur, D | 1 |
| Ahmed, S | 1 |
| Subramaniam, S | 1 |
| Modgill, VK | 1 |
| Banerjee, AK | 1 |
| Rautenstrauch, J | 1 |
| Coskun, A | 1 |
| Duzgun, SA | 1 |
| Uzunkoy, A | 1 |
| Bozer, M | 1 |
| Aslan, O | 1 |
| Canbeyli, B | 1 |
| Cavcić, J | 1 |
| Turcić, J | 1 |
| Martinac, P | 1 |
| Mestrović, T | 1 |
| Mladina, R | 1 |
| Pezerović-Panijan, R | 1 |
| Wasvary, HJ | 1 |
| Hain, J | 1 |
| Mosed-Vogel, M | 1 |
| Bendick, P | 1 |
| Barkel, DC | 1 |
| Klein, SN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Topical Application of GTN 0.4% in the Treatment of Anismus Following Stapled Haemorrhoidopexy[NCT01279551] | Phase 2/Phase 3 | 40 participants (Actual) | Interventional | 2004-01-31 | Completed | ||
| Randomised, Double-blind, Placebo-controlled, Parallel-group, Multicentre, Interventional Clinical Trial to Assess the Efficacy and Safety of the Food Supplement Microsmin® Plus in the Symptomatic Treatment of Haemorrhoids[NCT05750563] | 80 participants (Anticipated) | Interventional | 2023-02-28 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for nitroglycerin and Hemorrhoids
| Article | Year |
|---|---|
Effect of Glyceryl Trinitrate Ointment on Pain Control After Hemorrhoidectomy: A Meta-analysis of Randomized Controlled Trials.
Topics: Analgesics, Non-Narcotic; Headache; Hemorrhoidectomy; Hemorrhoids; Humans; Nitroglycerin; Ointments; | 2016 |
Meta-analysis of the use of glyceryl trinitrate ointment after haemorrhoidectomy as an analgesic and in promoting wound healing.
Topics: Analgesics; Headache; Hemorrhoids; Humans; Nitroglycerin; Ointments; Pain Measurement; Pain, Postope | 2010 |
A literature review on the role of chemical sphincterotomy after Milligan-Morgan hemorrhoidectomy.
Topics: Anal Canal; Analgesia; Botulinum Toxins; Calcium Channel Blockers; Digestive System Surgical Procedu | 2011 |
13 trials available for nitroglycerin and Hemorrhoids
| Article | Year |
|---|---|
Topical glyceryl trinitrate ointment for pain related to anal hypertonia after stapled hemorrhoidopexy: a randomized controlled trial.
Topics: Administration, Topical; Adult; Anal Canal; Female; Hemorrhoids; Humans; Lidocaine; Male; Middle Age | 2013 |
Efficacy of combination of 0.2% GTN and lignocaine ointments in wound healing and pain relief after Milligan Morgan hemorrhoidectomy--a comparison with lignocaine and 0.2% GTN ointments separately.
Topics: Adult; Anesthetics, Local; Double-Blind Method; Female; Hemorrhoidectomy; Hemorrhoids; Humans; Lidoc | 2014 |
The effect of glyceryl trinitrate ointment on posthemorrhoidectomy pain and wound healing: results of a randomized, double-blind, placebo-controlled study.
Topics: Administration, Topical; Adult; Analgesics; Double-Blind Method; Female; Hemorrhoids; Humans; Male; | 2009 |
Role of 0.4% glyceryl trinitrate ointment after haemorrhoidectomy: results of a prospective randomised study.
Topics: Adult; Aged; Demography; Female; Hemorrhoidectomy; Hemorrhoids; Humans; Male; Middle Aged; Nitroglyc | 2013 |
Initial study to assess the effects of topical glyceryl trinitrate for pain after haemorrhoidectomy.
Topics: Administration, Topical; Aged; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up | 2001 |
Effect of 0.2 percent glyceryl trinitrate ointment on wound healing after a hemorrhoidectomy: results of a randomized, prospective, double-blind, placebo-controlled trial.
Topics: Administration, Topical; Adult; Double-Blind Method; Female; Hemorrhoids; Humans; Male; Middle Aged; | 2003 |
Botulinum toxin vs. topical glyceryl trinitrate ointment for pain control in patients undergoing hemorrhoidectomy: a randomized trial.
Topics: Adult; Botulinum Toxins, Type A; Defecation; Female; Hemorrhoids; Humans; Injections; Male; Manometr | 2006 |
Randomized clinical trial of 0.2 per cent glyceryl trinitrate ointment for wound healing and pain reduction after open diathermy haemorrhoidectomy.
Topics: Adult; Analgesics; Diathermy; Double-Blind Method; Female; Hemorrhoids; Humans; Male; Middle Aged; N | 2006 |
Rectogesic (glyceryl trinitrate 0.2%) ointment relieves symptoms of haemorrhoids associated with high resting anal canal pressures.
Topics: Adult; Aged; Anal Canal; Female; Hemorrhage; Hemorrhoids; Humans; Male; Manometry; Middle Aged; Nitr | 2007 |
Biochemical sphincterotomy is effective treatment for haemorrhoids and associated conditions: an audit.
Topics: Hemorrhoids; Humans; Medical Audit; Nitric Oxide Donors; Nitroglycerin; Prospective Studies | 1998 |
Nitroderm TTS band application for pain after hemorrhoidectomy.
Topics: Administration, Cutaneous; Adult; Aged; Anal Canal; Female; Hemorrhoids; Humans; Male; Manometry; Mi | 2001 |
Comparison of topically applied 0.2% glyceryl trinitrate ointment, incision and excision in the treatment of perianal thrombosis.
Topics: Administration, Topical; Anesthesia, Local; Follow-Up Studies; Hemorrhoids; Humans; Nitroglycerin; O | 2001 |
Randomized, prospective, double-blind, placebo-controlled trial of effect of nitroglycerin ointment on pain after hemorrhoidectomy.
Topics: Administration, Topical; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration | 2001 |
6 other studies available for nitroglycerin and Hemorrhoids
| Article | Year |
|---|---|
Causes and Management of Pruritus Ani.
Topics: Fissure in Ano; Hemorrhoids; Humans; Male; Methylene Blue; Middle Aged; Nitroglycerin; Pruritus Ani | 2023 |
Causes and Management of Pruritus Ani.
Topics: Fissure in Ano; Hemorrhoids; Humans; Male; Methylene Blue; Middle Aged; Nitroglycerin; Pruritus Ani | 2023 |
Causes and Management of Pruritus Ani.
Topics: Fissure in Ano; Hemorrhoids; Humans; Male; Methylene Blue; Middle Aged; Nitroglycerin; Pruritus Ani | 2023 |
Causes and Management of Pruritus Ani.
Topics: Fissure in Ano; Hemorrhoids; Humans; Male; Methylene Blue; Middle Aged; Nitroglycerin; Pruritus Ani | 2023 |
Re: Meta-analysis of the use of glyceryl trinitrate ointment after haemorrhoidectomy as an analgesic and in promoting wound healing.
Topics: Analgesics; Hemorrhoids; Humans; Meta-Analysis as Topic; Nitroglycerin; Ointments; Pain, Postoperati | 2011 |
[Anorectal diseases: an update].
Topics: Anus Diseases; Biofeedback, Psychology; Electric Stimulation Therapy; Fecal Incontinence; Fissure in | 2012 |
GTN headaches and reduction of natural banding?
Topics: Administration, Topical; Dose-Response Relationship, Drug; Fissure in Ano; Follow-Up Studies; Headac | 2008 |
Treatment of benign anal disease with topical nitroglycerin.
Topics: Administration, Topical; Adult; Anal Canal; Defecation; Female; Fissure in Ano; Follow-Up Studies; H | 1995 |
[News in the anorectal area. Heart salve and stapler against anal diseases].
Topics: Fissure in Ano; Hemorrhoids; Humans; Nitroglycerin; Ointments; Surgical Staplers | 2000 |