nitroglycerin has been researched along with Headache in 157 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Headache: The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There was an overall 22 percent decreased incidence of mastectomy flap necrosis in the nitroglycerin ointment cohort (47." | 9.27 | Nitroglycerin Ointment for Reducing the Rate of Mastectomy Flap Necrosis in Immediate Implant-Based Breast Reconstruction. ( Fine, N; Li, DD; Turin, SY; Vaca, EE, 2018) |
| " To control for the confounding effects of analgesics, all patients received 650 mg acetaminophen for headache prophylaxis before each application." | 9.17 | Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study. ( Barish, CF; Berry, SM; Bhandari, R; Clark, G; Collins, GV; Howell, J; Pappas, JE; Riff, DS; Safdi, M; Yellowlees, A, 2013) |
| " Nitroglycerin (NTG) administration commonly causes a headache with some features similar to those of a migraine." | 9.09 | The pharmacodynamics of sumatriptan in nitroglycerin-induced headache. ( Forrest, A; Fullerton, T; Gengo, FM; Komorowski-Swiatek, D, 1999) |
| "Although treatment with either topical nitroglycerin or botulinum toxin is effective as an alternative to surgery for patients with chronic anal fissure, botulinum toxin is the more effective nonsurgical treatment." | 9.09 | A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. ( Albanese, A; Bentivoglio, AR; Brisinda, G; Cassetta, E; Gui, D; Maria, G, 1999) |
| "Sumatriptan is a selective 5-hydroxytryptamine1d (5-HT1d)-receptor agonist, highly effective in the short-term treatment of migraine headaches." | 9.08 | Cerebral and ocular hemodynamic effects of sumatriptan in the nitroglycerin headache model. ( Eichler, HG; Findl, O; Graselli, U; Krejcy, K; Schmetterer, L; Singer, EA; Wolzt, M, 1996) |
| "Topical application of nitroglycerine represents a new, easily handled, and effective alternative in the treatment of anal fissures." | 9.08 | Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy? ( Bacher, H; Cerwenka, H; El-Shabrawi, A; Mischinger, HJ; Pfeifer, J; Schweiger, W; Werkgartner, G, 1997) |
| "Nitroglycerin-(NTG)-induced headache and dilatation of the radial artery were followed in a double blind, randomized, placebo-controlled, cross-over study in 6 healthy volunteers." | 9.07 | Lack of tolerance of headache and radial artery diameter during a 7 hour intravenous infusion of nitroglycerin. ( Iversen, HK; Nielsen, TH; Olesen, J; Tfelt-Hansen, P, 1993) |
| "The effects of N-acetylcysteine, a sulfhydryl group donor, on nitroglycerin-induced headache and dilation of temporal and radial arteries were investigated in 11 healthy volunteers." | 9.07 | N-acetylcysteine enhances nitroglycerin-induced headache and cranial arterial responses. ( Iversen, HK, 1992) |
| "The purpose of this study was to determine the effect of site of nitroglycerin ointment placement on headache and flushing in healthy subjects." | 9.07 | Effect of nitroglycerin ointment placement on headache and flushing in healthy subjects. ( Riegel, B; Shively, M, 1991) |
| "3 years) with stable exercise-induced angina pectoris were enrolled in this within-patient, placebo-controlled study aimed at comparing the efficacy of the continuous and intermittent (12 hour on, 12 hour off) application of transdermal nitroglycerin." | 9.07 | Efficacy of continuous and intermittent transdermal treatment with nitroglycerin in effort angina pectoris: a multicentric study. The Collaborative Nitro Group. ( Camerini, F; Pandullo, C; Pollavini, G; Scardi, S, 1991) |
| "Fifty-six patients with cardiac disease participated in a study to determine the effect of site placement on patient reports of headache and flushing after topical nitroglycerin ointment placement." | 9.06 | Effect of nitroglycerin ointment placement on the severity of headache and flushing in patients with cardiac disease. ( Heywood, G; Jackson, W; Kennedy, A; Riegel, B, 1988) |
| "To assess the safety and efficacy of NO donors, L-arginine, and NOS-I in people with acute stroke." | 8.95 | Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke. ( Appleton, JP; Bath, PM; Krishnan, K, 2017) |
| "The study analyzed clinical trials investigating the effectiveness of diltiazem (DTZ) and glyceryltrinitrate (GTN) for the nonsurgical management of chronic anal fissure (CAF)." | 8.89 | Systematic review of the use of topical diltiazem compared with glyceryltrinitrate for the nonoperative management of chronic anal fissure. ( Baig, MK; Sains, P; Sajid, MS; Whitehouse, PA, 2013) |
| "The objective of this review is to systematically analyze the prospective randomized controlled trials on the effectiveness of diltiazem (DTZ) and glyceryltrinitrate (GTN) for the pharmacological management of chronic anal fissure (CAF)." | 8.84 | The efficacy of diltiazem and glyceryltrinitrate for the medical management of chronic anal fissure: a meta-analysis. ( Baig, MK; Cheek, E; Rimple, J; Sajid, MS, 2008) |
| "This study explores the evidence-based background for treating chronic anal fissure with topically applied nitroglycerin (NTG): in part the general effect of NTG and in part how its effect compares to that of surgery, which has been claimed to have long-term complications like incontinence for flatus and faeces." | 8.81 | [Treatment of chronic anal fissure with topically applied nitroglycerin ointment. A systematic review of evidence-based results]. ( Matzen, P; Svendsen, CB, 2002) |
| "Nitroglycerin (NTG)-induced headache is the most common side effect of nitrate therapy and negatively affects the quality of life." | 8.31 | The effect of local cold compresses for nitroglycerin-induced headache: An observational pretest-posttest study. ( Enç, N; Uğurlu, YK, 2023) |
| "The essential use of riboflavin is the prevention of migraine headaches, although its effect on migraines is considered to be associated with the increased mitochondrial energy metabolism." | 7.81 | Riboflavin and vitamin E increase brain calcium and antioxidants, and microsomal calcium-ATP-ase values in rat headache models induced by glyceryl trinitrate. ( Bütün, A; Çelik, Ö; Demirci, S; Nazıroğlu, M; Uğuz, AC, 2015) |
| "A novel, sensitive and reliable ultra fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method has been developed and validated for simultaneous quantitation of eight main active ingredients (evodiamine, rutaecarpine, dehydroevodiamine, limonin, ginsenoside Rb1, Rd, Re and Rg1) in rat plasma after oral administration of Wu-Zhu-Yu (WZY) decoction, which is a celebrated and widely used Traditional Chinese Medicine formula for the treatment of headache." | 7.79 | Simultaneous determination of three alkaloids, four ginsenosides and limonin in the plasma of normal and headache rats after oral administration of Wu-Zhu-Yu decoction by a novel ultra fast liquid chromatography-tandem mass spectrometry method: applicatio ( Bi, K; Chen, X; He, B; Li, Q; Liu, R; Lv, C; Sun, W; Xu, H; Yin, Y, 2013) |
| "In migraineurs nitroglycerin (NTG) induces severe delayed headache, resembling spontaneous migraine attacks." | 7.72 | Nitroglycerin induces migraine headache and central sensitization phenomena in patients with migraine without aura: a study of laser evoked potentials. ( Cerbo, R; de Tommaso, M; Difruscolo, O; Guido, M; Libro, G; Losito, L; Sardaro, M, 2004) |
| "two types of headache developed after the nitroglycerin administration: (1) an immediate headache that does not fulfil the criteria for migraine, mild and disappears spontaneously within 1 hour; (2) a typical migraine attack without aura develops several hours after the nitroglycerin administration (mean latency: 250 min), moderate or severe, and warrants antimigraine therapy." | 7.72 | [Nitroglycerin-induced headaches]. ( Bagdy, G; Gonda, X; Juhász, G; Zsombók, T, 2004) |
| "Adverse reactions associated with sublingual nitroglycerin administration were investigated in 103 patients, 71 men and 32 women (mean age 56 +/- 11 years), 32 patients with coronary artery stenosis and 71 without coronary artery stenosis." | 7.71 | [Headache due to nitroglycerin administration and its clinical significance]. ( Aoyagi, K; Hitsumoto, T; Iizuka, T; Kaku, M; Kanai, M; Matsumoto, J; Noike, H; Ohsawa, H; Sakurai, T; Sugiyama, Y; Yoshinaga, K, 2002) |
| "Headache often accompanies treatment with nitroglycerin, but the cerebral hemodynamic effects and the exact mechanism of the headache are incompletely understood." | 7.69 | Middle cerebral artery velocity correlates with nitroglycerin-induced headache onset. ( Davidai, G; Davis, RL; Gabriel, H; Gengo, FM; Knappertz, VA; Tegeler, CH; Troost, BT, 1996) |
| "Diltiazem gel was found to be superior to Glyceril trinitrate ointment due to significantly higher healing rate and fewer side-effects." | 6.77 | Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double-blind trial. ( Ala, S; Ghorbanian, A; Hadianamrei, R; Saeedi, M, 2012) |
| "Headache was registered for 12 h after GTN infusions." | 6.71 | The effect of propranolol on glyceryltrinitrate-induced headache and arterial response. ( Gibson, A; Iversen, HK; Jenkins, K; Olesen, J; Peck, R; Thomsen, LL; Tvedskov, JF; Williams, P, 2004) |
| "Primary dysmenorrhea is a syndrome characterized by painful uterine contractility caused by a hypersecretion of endometrial prostaglandins; non-steroidal anti-inflammatory drugs are the first choice for its treatment." | 6.70 | A comparison of glyceryl trinitrate with diclofenac for the treatment of primary dysmenorrhea: an open, randomized, cross-over trial. ( Facchinetti, F; Piccinini, F; Sgarbi, L; Volpe, A, 2002) |
| "Headache was rated on a 10 points scale." | 6.68 | Headache induced by a nitric oxide donor (nitroglycerin) responds to sumatriptan. A human model for development of migraine drugs. ( Iversen, HK; Olesen, J, 1996) |
| "Headache was common following IS-5-MN (13 patients) and the combination (11 patients)." | 6.66 | Effects of diltiazem and isosorbide-5-mononitrate, alone and in combination, on patients with stable angina pectoris. ( Ake, H; Arina, R; Emanuelsson, H; Kristi, M, 1989) |
| " Plasma nitroglycerin levels demonstrated consistently high plasma levels over each 24-hour dosing interval, on day 1, week 1, and week 2." | 6.66 | Sustained high-dose nitroglycerin transcutaneous patch therapy in angina pectoris: evidence for attenuation of effect over time. ( Frishman, WH; Giles, T; Greenberg, S; Heiman, M; Laifer, L; Lazar, E; Nadelmann, J; Raffidal, L; Soberman, J; Strom, J, 1989) |
| " In a double-blind study the effects of continuous (24 h/day) and intermittent (16 h/day) application of transdermal nitroglycerin in a dosage of 10 mg/day were compared with the effects of placebo in 12 patients with chronic stable angina receiving treatment with beta-adrenergic blocking or calcium channel blocking agents." | 6.66 | Transdermal nitroglycerin in angina pectoris: efficacy of intermittent application. ( Coxon, R; Luke, R; Sharpe, N, 1987) |
| "Headaches were common with glyceryl trinitrate cream." | 6.66 | Assessment of dermal glyceryl trinitrate and isosorbide dinitrate for patients with angina pectoris. ( Galer, IA; Hubner, PJ; Jones, PR, 1985) |
| "Migraine is one of the most common neurological disorders characterized by recurrent attacks of typically throbbing and unilateral headaches, affecting up to 20% of the population worldwide." | 5.62 | Protein kinase Cδ as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice. ( He, Y; Kashyap, Y; Messing, RO; Shi, Z; Wang, ZJ, 2021) |
| "Several cases of symptomatic hemicrania continua (HC) have been reported." | 5.46 | Hemicrania Continua-Like Headache Related to Transdermal Nitroglycerine Therapy. ( Maggioni, F; Mainardi, F; Zanchin, G, 2017) |
| "Migraine headaches are considered to be associated with increased mitochondrial energy metabolism." | 5.42 | Protective effects of riboflavin and selenium on brain microsomal Ca2+-ATPase and oxidative damage caused by glyceryl trinitrate in a rat headache model. ( Bütün, A; Çelik, Ö; Nazıroğlu, M; Uğuz, AC, 2015) |
| "The ability to scan repeatedly a patient without radiation and with non-invasive imaging modalities, as well as the recognition that human experimental migraine provocation compounds, such as nitroglycerin (NTG) and pituitary adenylate cyclase activating polypeptide (PACAP), can trigger typical premonitory symptoms (PS) and migraine-like headache in patients with migraine, have allowed feasible and reproducible imaging of the premonitory phase using NTG." | 5.41 | Neuroimaging in the pre-ictal or premonitory phase of migraine: a narrative review. ( Goadsby, PJ; Karsan, N, 2023) |
| "Nitroglycerin was given sublingually to 27 patients." | 5.29 | Cervicogenic headache: responses to nitroglycerin, oxygen, ergotamine and morphine. ( Bovim, G; Sjaastad, O, 1993) |
| "Nitroglycerin plasters were applied to the penis in 10 impotent men and the erectile effect assessed." | 5.28 | Non-invasive management of impotence with transcutaneous nitroglycerin. ( Bødker, A; Meyhoff, HH; Rosenkilde, P, 1992) |
| "There was an overall 22 percent decreased incidence of mastectomy flap necrosis in the nitroglycerin ointment cohort (47." | 5.27 | Nitroglycerin Ointment for Reducing the Rate of Mastectomy Flap Necrosis in Immediate Implant-Based Breast Reconstruction. ( Fine, N; Li, DD; Turin, SY; Vaca, EE, 2018) |
| " To control for the confounding effects of analgesics, all patients received 650 mg acetaminophen for headache prophylaxis before each application." | 5.17 | Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study. ( Barish, CF; Berry, SM; Bhandari, R; Clark, G; Collins, GV; Howell, J; Pappas, JE; Riff, DS; Safdi, M; Yellowlees, A, 2013) |
| "This will be an open-label randomized, controlled trial conducted at Women's College Hospital comparing five formulations of nitrates for their effects on bone turnover markers and headache." | 5.17 | Nitrates and bone turnover (NABT) - trial to select the best nitrate preparation: study protocol for a randomized controlled trial. ( Bucur, RC; Cummings, SR; Hamilton, CJ; Jamal, SA; Reid, LS, 2013) |
| "Application of nitroglycerin (glyceryl trinitrate) ointment with perianal administration is a widely used treatment for chronic anal fissure." | 5.16 | Perianal versus endoanal application of glyceryl trinitrate 0.4% ointment in the treatment of chronic anal fissure: results of a randomized controlled trial. Is this the solution to the headaches? ( Arroyo, A; Calpena, R; Candela, F; Frangi, A; Moya, P; Oliver, MI; Pérez-Legaz, J; Ruiz-Tovar, J, 2012) |
| "Sublingual nitroglycerin was associated with a higher rate of headache and did not improve the rate of successful external cephalic version." | 5.10 | Sublingual nitroglycerin versus placebo as a tocolytic for external cephalic version: a randomized controlled trial in parous women. ( Berman, S; Boucher, M; Bujold, E; Ferreira, E; Marquette, GP; Rinfret, D, 2003) |
| " Nitroglycerin (NTG) administration commonly causes a headache with some features similar to those of a migraine." | 5.09 | The pharmacodynamics of sumatriptan in nitroglycerin-induced headache. ( Forrest, A; Fullerton, T; Gengo, FM; Komorowski-Swiatek, D, 1999) |
| "Although treatment with either topical nitroglycerin or botulinum toxin is effective as an alternative to surgery for patients with chronic anal fissure, botulinum toxin is the more effective nonsurgical treatment." | 5.09 | A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. ( Albanese, A; Bentivoglio, AR; Brisinda, G; Cassetta, E; Gui, D; Maria, G, 1999) |
| "Sumatriptan is a selective 5-hydroxytryptamine1d (5-HT1d)-receptor agonist, highly effective in the short-term treatment of migraine headaches." | 5.08 | Cerebral and ocular hemodynamic effects of sumatriptan in the nitroglycerin headache model. ( Eichler, HG; Findl, O; Graselli, U; Krejcy, K; Schmetterer, L; Singer, EA; Wolzt, M, 1996) |
| "Topical application of nitroglycerine represents a new, easily handled, and effective alternative in the treatment of anal fissures." | 5.08 | Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy? ( Bacher, H; Cerwenka, H; El-Shabrawi, A; Mischinger, HJ; Pfeifer, J; Schweiger, W; Werkgartner, G, 1997) |
| "Nitroglycerin-(NTG)-induced headache and dilatation of the radial artery were followed in a double blind, randomized, placebo-controlled, cross-over study in 6 healthy volunteers." | 5.07 | Lack of tolerance of headache and radial artery diameter during a 7 hour intravenous infusion of nitroglycerin. ( Iversen, HK; Nielsen, TH; Olesen, J; Tfelt-Hansen, P, 1993) |
| "The effects of N-acetylcysteine, a sulfhydryl group donor, on nitroglycerin-induced headache and dilation of temporal and radial arteries were investigated in 11 healthy volunteers." | 5.07 | N-acetylcysteine enhances nitroglycerin-induced headache and cranial arterial responses. ( Iversen, HK, 1992) |
| "The purpose of this study was to determine the effect of site of nitroglycerin ointment placement on headache and flushing in healthy subjects." | 5.07 | Effect of nitroglycerin ointment placement on headache and flushing in healthy subjects. ( Riegel, B; Shively, M, 1991) |
| "3 years) with stable exercise-induced angina pectoris were enrolled in this within-patient, placebo-controlled study aimed at comparing the efficacy of the continuous and intermittent (12 hour on, 12 hour off) application of transdermal nitroglycerin." | 5.07 | Efficacy of continuous and intermittent transdermal treatment with nitroglycerin in effort angina pectoris: a multicentric study. The Collaborative Nitro Group. ( Camerini, F; Pandullo, C; Pollavini, G; Scardi, S, 1991) |
| "Fifty-six patients with cardiac disease participated in a study to determine the effect of site placement on patient reports of headache and flushing after topical nitroglycerin ointment placement." | 5.06 | Effect of nitroglycerin ointment placement on the severity of headache and flushing in patients with cardiac disease. ( Heywood, G; Jackson, W; Kennedy, A; Riegel, B, 1988) |
| "Molsidomine was compared with propranolol for anti-anginal efficacy in a double-blind, cross-over, fixed-dose clinical trial, involving 39 patients with moderate, stable angina pectoris, and objective evidence of coronary sclerosis." | 5.05 | Molsidomine, an effective long-acting anti-anginal drug. ( Balakumaran, K; Chadha, DR; Hugenholtz, PG; Tijssen, JG, 1983) |
| "To assess the safety and efficacy of NO donors, L-arginine, and NOS-I in people with acute stroke." | 4.95 | Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke. ( Appleton, JP; Bath, PM; Krishnan, K, 2017) |
| " Nitroglycerin administration was not associated with an increase in headaches (RR 1." | 4.91 | Nitroglycerin for management of retained placenta. ( Abdel-Aleem, H; Abdel-Aleem, MA; Shaaban, OM, 2015) |
| "The study analyzed clinical trials investigating the effectiveness of diltiazem (DTZ) and glyceryltrinitrate (GTN) for the nonsurgical management of chronic anal fissure (CAF)." | 4.89 | Systematic review of the use of topical diltiazem compared with glyceryltrinitrate for the nonoperative management of chronic anal fissure. ( Baig, MK; Sains, P; Sajid, MS; Whitehouse, PA, 2013) |
| "The objective of this review is to systematically analyze the prospective randomized controlled trials on the effectiveness of diltiazem (DTZ) and glyceryltrinitrate (GTN) for the pharmacological management of chronic anal fissure (CAF)." | 4.84 | The efficacy of diltiazem and glyceryltrinitrate for the medical management of chronic anal fissure: a meta-analysis. ( Baig, MK; Cheek, E; Rimple, J; Sajid, MS, 2008) |
| "This study explores the evidence-based background for treating chronic anal fissure with topically applied nitroglycerin (NTG): in part the general effect of NTG and in part how its effect compares to that of surgery, which has been claimed to have long-term complications like incontinence for flatus and faeces." | 4.81 | [Treatment of chronic anal fissure with topically applied nitroglycerin ointment. A systematic review of evidence-based results]. ( Matzen, P; Svendsen, CB, 2002) |
| "Nitric oxide (NO) may play a key role in migraine and other vascular headaches since glyceryl trinitrate (a donor of NO) and histamine (which probably activates endothelial NO formation) both cause a pulsating dose-dependent headache with several migrainous characteristics." | 4.79 | Nitric oxide is a key molecule in migraine and other vascular headaches. ( Iversen, H; Olesen, J; Thomsen, LL, 1994) |
| "Nitroglycerin (NTG)-induced headache is the most common side effect of nitrate therapy and negatively affects the quality of life." | 4.31 | The effect of local cold compresses for nitroglycerin-induced headache: An observational pretest-posttest study. ( Enç, N; Uğurlu, YK, 2023) |
| "The essential use of riboflavin is the prevention of migraine headaches, although its effect on migraines is considered to be associated with the increased mitochondrial energy metabolism." | 3.81 | Riboflavin and vitamin E increase brain calcium and antioxidants, and microsomal calcium-ATP-ase values in rat headache models induced by glyceryl trinitrate. ( Bütün, A; Çelik, Ö; Demirci, S; Nazıroğlu, M; Uğuz, AC, 2015) |
| "A novel, sensitive and reliable ultra fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method has been developed and validated for simultaneous quantitation of eight main active ingredients (evodiamine, rutaecarpine, dehydroevodiamine, limonin, ginsenoside Rb1, Rd, Re and Rg1) in rat plasma after oral administration of Wu-Zhu-Yu (WZY) decoction, which is a celebrated and widely used Traditional Chinese Medicine formula for the treatment of headache." | 3.79 | Simultaneous determination of three alkaloids, four ginsenosides and limonin in the plasma of normal and headache rats after oral administration of Wu-Zhu-Yu decoction by a novel ultra fast liquid chromatography-tandem mass spectrometry method: applicatio ( Bi, K; Chen, X; He, B; Li, Q; Liu, R; Lv, C; Sun, W; Xu, H; Yin, Y, 2013) |
| "In migraineurs nitroglycerin (NTG) induces severe delayed headache, resembling spontaneous migraine attacks." | 3.72 | Nitroglycerin induces migraine headache and central sensitization phenomena in patients with migraine without aura: a study of laser evoked potentials. ( Cerbo, R; de Tommaso, M; Difruscolo, O; Guido, M; Libro, G; Losito, L; Sardaro, M, 2004) |
| "two types of headache developed after the nitroglycerin administration: (1) an immediate headache that does not fulfil the criteria for migraine, mild and disappears spontaneously within 1 hour; (2) a typical migraine attack without aura develops several hours after the nitroglycerin administration (mean latency: 250 min), moderate or severe, and warrants antimigraine therapy." | 3.72 | [Nitroglycerin-induced headaches]. ( Bagdy, G; Gonda, X; Juhász, G; Zsombók, T, 2004) |
| "Adverse reactions associated with sublingual nitroglycerin administration were investigated in 103 patients, 71 men and 32 women (mean age 56 +/- 11 years), 32 patients with coronary artery stenosis and 71 without coronary artery stenosis." | 3.71 | [Headache due to nitroglycerin administration and its clinical significance]. ( Aoyagi, K; Hitsumoto, T; Iizuka, T; Kaku, M; Kanai, M; Matsumoto, J; Noike, H; Ohsawa, H; Sakurai, T; Sugiyama, Y; Yoshinaga, K, 2002) |
| "Headache research in Denmark started with the description in 1949 by Dalsgaard-Nielsen of the percutaneous nitroglycerin test." | 3.71 | History of headache research in Denmark. ( Tfelt-Hansen, P, 2001) |
| " This report documents a therapeutic role for nitroglycerin, a nitric oxide donor, in the treatment of acutely thrombosed external hemorrhoids and anal fissure." | 3.69 | Treatment of benign anal disease with topical nitroglycerin. ( Gorfine, SR, 1995) |
| "Headache often accompanies treatment with nitroglycerin, but the cerebral hemodynamic effects and the exact mechanism of the headache are incompletely understood." | 3.69 | Middle cerebral artery velocity correlates with nitroglycerin-induced headache onset. ( Davidai, G; Davis, RL; Gabriel, H; Gengo, FM; Knappertz, VA; Tegeler, CH; Troost, BT, 1996) |
| "Six patients with episodic cluster headache were investigated as to blood pressure, heart rate, cerebrospinal fluid pressure (Pcsf) and frontal vein pressure (Pvf) during five nitroglycerin (NG) provoked attacks and one spontaneous attack." | 3.68 | Cerebrospinal fluid pressure and venous pressure in "dynamite headache" and cluster headache attacks. ( Greitz, D; Hannerz, J, 1992) |
| "The authors studied the volume velocity of extracranial blood flow by an original method of venous occlusional cranial pletysmography in 40 individuals with headaches of stress and in 30 examinees without headaches in conditions of calmness and in stress influences (cold test, terminal desympathization, counting by mind and a nitroglycerine test)." | 3.65 | [Role of the vascular component in the pathogenesis of headaches in neurotic patients]. ( Birka, EA; Perli, PD, 1977) |
| "Fifty-three patients with migraine were enrolled; imaging on at least one triggered visit was obtained from 25 patients, with 21 patients completing the entire imaging protocol including a placebo visit." | 3.30 | Regional cerebral perfusion during the premonitory phase of triggered migraine: A double-blind randomized placebo-controlled functional imaging study using pseudo-continuous arterial spin labeling. ( Bose, RP; Goadsby, PJ; Karsan, N; O'Daly, O; Zelaya, F, 2023) |
| "Diltiazem gel was found to be superior to Glyceril trinitrate ointment due to significantly higher healing rate and fewer side-effects." | 2.77 | Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double-blind trial. ( Ala, S; Ghorbanian, A; Hadianamrei, R; Saeedi, M, 2012) |
| "Headache was scored for 85 min." | 2.75 | No effect of pure oxygen inhalation on headache induced by glyceryl trinitrate. ( Daugaard, D; Iversen, HK; Olesen, J; Tfelt-Hansen, P; Thomsen, LL, 2010) |
| " Outcome parameters were (1) the effects on fetal and maternal heart frequency (FHF/MHF) and blood pressure, and (2) subjective experiences of adverse effects assessed by utilising a questionnaire." | 2.71 | Maternal and fetal side effects of tocolysis using transdermal nitroglycerin or intravenous fenoterol combined with magnesium sulfate. ( Gross, W; Kähler, C; Möller, A; Möller, U; Richter, S; Schleussner, E; Seewald, HJ, 2003) |
| "Headache was registered for 12 h after GTN infusions." | 2.71 | The effect of propranolol on glyceryltrinitrate-induced headache and arterial response. ( Gibson, A; Iversen, HK; Jenkins, K; Olesen, J; Peck, R; Thomsen, LL; Tvedskov, JF; Williams, P, 2004) |
| "Patients with a Crohn's disease activity index of > or = 150 and < 450 were randomized to receive 12 weeks of either glyceryl trinitrate (initially 6 mg twice daily, increasing to 9 mg twice daily after 6 weeks) or an identical placebo." | 2.70 | Enteric-release glyceryl trinitrate in active Crohn's disease: a randomized, double-blind, placebo-controlled trial. ( Ch'Ng, CL; Evans, BK; Green, JT; Hawkes, ND; Hawthorne, AB; Kingham, JG; Mayberry, JF; Rhodes, J; Rhodes, P; Richardson, C; Swift, GL; Thomas, GA; Williams, J, 2001) |
| "Primary dysmenorrhea is a syndrome characterized by painful uterine contractility caused by a hypersecretion of endometrial prostaglandins; non-steroidal anti-inflammatory drugs are the first choice for its treatment." | 2.70 | A comparison of glyceryl trinitrate with diclofenac for the treatment of primary dysmenorrhea: an open, randomized, cross-over trial. ( Facchinetti, F; Piccinini, F; Sgarbi, L; Volpe, A, 2002) |
| "Internal anal sphincterotomy for treating chronic anal fissure can irreversibly damage anal continence." | 2.69 | Glyceryl trinitrate for chronic anal fissure--healing or headache? Results of a multicenter, randomized, placebo-controled, double-blind trial. ( Altomare, DF; Arcanà, F; Bottini, C; Lovreglio, R; Milito, G; Nardelli, N; Pescatori, M; Pulvirenti-D'Urso, A; Rinaldi, M; Scardigno, D; Spinelli, F, 2000) |
| " The ratios of the Cmax were within said limits for the signal metabolite 1,2-GDN and only slightly below (0." | 2.69 | Bioavailability and pharmacokinetic profile of glyceryl trinitrate and of glyceryl dinitrates during application of a new glyceryl trinitrate transdermal patch. ( Caplain, H; Gualano, V; Rovati, LC; Santoro, A; Setnikar, I, 2000) |
| "The pharmacokinetic characteristics and the bioavailability of glyceryl trinitrate (GTN, CAS 55-63-0) and of its main metabolities 1,2-glyceryl dinitrate (1,2-GDN, CAS 621-65-8) and 1,3-glyceryl dinitrate (1,3-GDN, CAS 623-87-0) during a single 24-h application of three strengths of a newly developed GTN transdermal patch (Epinitril) were investigated." | 2.69 | Plasma levels of glyceryl trinitrate and dinitrates during application of three strengths of a new glyceryl trinitrate transdermal patch. ( Caplain, H; Follet, M; Gualano, V; Rovati, LC; Santoro, A; Setnikar, I, 2000) |
| "Headache was rated on a 10 points scale." | 2.68 | Headache induced by a nitric oxide donor (nitroglycerin) responds to sumatriptan. A human model for development of migraine drugs. ( Iversen, HK; Olesen, J, 1996) |
| "In a double-blind, randomized, placebo cross-controlled trial the effectiveness and the adverse effects of two types of buccal tablets containing 5 mg nitroglycerin: Polnitrin produced by Warsaw Pharmaceutical Works POLFA and its analogue of foreign origin, were assessed." | 2.67 | [Evaluation of clinical effectiveness and adverse effects of Polnitrin]. ( Kośmicki, M; Sadowski, Z, 1992) |
| "Headache was common following IS-5-MN (13 patients) and the combination (11 patients)." | 2.66 | Effects of diltiazem and isosorbide-5-mononitrate, alone and in combination, on patients with stable angina pectoris. ( Ake, H; Arina, R; Emanuelsson, H; Kristi, M, 1989) |
| " Plasma nitroglycerin levels demonstrated consistently high plasma levels over each 24-hour dosing interval, on day 1, week 1, and week 2." | 2.66 | Sustained high-dose nitroglycerin transcutaneous patch therapy in angina pectoris: evidence for attenuation of effect over time. ( Frishman, WH; Giles, T; Greenberg, S; Heiman, M; Laifer, L; Lazar, E; Nadelmann, J; Raffidal, L; Soberman, J; Strom, J, 1989) |
| "Headaches were more common in patients with active patches but were relieved by simple analgesics." | 2.66 | Use of transdermal glyceryl trinitrate to reduce failure of intravenous infusion due to phlebitis and extravasation. ( Hecker, JF; Lewis, GB; Wright, A, 1985) |
| " In a double-blind study the effects of continuous (24 h/day) and intermittent (16 h/day) application of transdermal nitroglycerin in a dosage of 10 mg/day were compared with the effects of placebo in 12 patients with chronic stable angina receiving treatment with beta-adrenergic blocking or calcium channel blocking agents." | 2.66 | Transdermal nitroglycerin in angina pectoris: efficacy of intermittent application. ( Coxon, R; Luke, R; Sharpe, N, 1987) |
| "Headaches were common with glyceryl trinitrate cream." | 2.66 | Assessment of dermal glyceryl trinitrate and isosorbide dinitrate for patients with angina pectoris. ( Galer, IA; Hubner, PJ; Jones, PR, 1985) |
| "Hemorrhoidectomy is associated with postoperative pain and prolonged wound healing." | 2.53 | Effect of Glyceryl Trinitrate Ointment on Pain Control After Hemorrhoidectomy: A Meta-analysis of Randomized Controlled Trials. ( Kiu, KT; Lin, CC; Liu, JW; Tam, KW; Wang, CY, 2016) |
| "The side effect of headache has often been an associated problem." | 2.46 | Meta-analysis of the use of glyceryl trinitrate ointment after haemorrhoidectomy as an analgesic and in promoting wound healing. ( Andreani, SM; Light, D; Patel, B; Ratnasingham, K; Uzzaman, M, 2010) |
| "Nitrates rarely cause coronary steal and myocardial ischaemia." | 2.43 | Side effects of using nitrates to treat angina. ( Rodgers, T; Thadani, U, 2006) |
| "Nitroglycerin induced activation of migraine-like central trigeminocervical neurons, and intracranial and extracranial neuronal hypersensitivity." | 1.62 | Therapeutic targeting of nitroglycerin-mediated trigeminovascular neuronal hypersensitivity predicts clinical outcomes of migraine abortives. ( Akerman, S; Bose, P; Goadsby, PJ; Hoffmann, JR; Holland, PR; Karsan, N; Romero-Reyes, M, 2021) |
| "Non-painful symptoms in migraine following headache resolution can last up to days." | 1.62 | The migraine postdrome: Spontaneous and triggered phenotypes. ( Bose, PR; Goadsby, PJ; Karsan, N; Nagaraj, K; Peréz-Rodríguez, A, 2021) |
| "Migraine is one of the most common neurological disorders characterized by recurrent attacks of typically throbbing and unilateral headaches, affecting up to 20% of the population worldwide." | 1.62 | Protein kinase Cδ as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice. ( He, Y; Kashyap, Y; Messing, RO; Shi, Z; Wang, ZJ, 2021) |
| "Ergotism is an ischaemic complication due to vasoconstriction throughout the body due to ingestion of ergotamine." | 1.48 | Headache in an HIV-Positive Patient: Dangerous Interaction. ( Garner, O; Iardino, A; Lorusso, G; Lotta, F, 2018) |
| "Glyceryl trinitrate causes prolonged mechanical allodynia in rodents, which temporally correlates with delayed glyceryl trinitrate-evoked migraine attacks in patients." | 1.48 | TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice. ( Benemei, S; Bunnett, NW; De Carvalho Goncalves, M; De Logu, F; Ferreira, J; Geppetti, P; Jain, P; Li Puma, S; Marone, IM; Materazzi, S; Nassini, R, 2018) |
| "Headache is a common episodic or chronic neurologic disorder." | 1.46 | Metabolomics Strategy Using High Resolution Mass Spectrometry Reveals Novel Biomarkers and Pain-Relief Effect of Traditional Chinese Medicine Prescription Wu-Zhu-Yu Decoction Acting on Headache Modelling Rats. ( Bi, K; Li, Q; Liu, R; Sui, Z; Wang, D; Wang, X; Xu, H; Yuan, Z; Zhang, X, 2017) |
| "Several cases of symptomatic hemicrania continua (HC) have been reported." | 1.46 | Hemicrania Continua-Like Headache Related to Transdermal Nitroglycerine Therapy. ( Maggioni, F; Mainardi, F; Zanchin, G, 2017) |
| "Migraine headaches are considered to be associated with increased mitochondrial energy metabolism." | 1.42 | Protective effects of riboflavin and selenium on brain microsomal Ca2+-ATPase and oxidative damage caused by glyceryl trinitrate in a rat headache model. ( Bütün, A; Çelik, Ö; Nazıroğlu, M; Uğuz, AC, 2015) |
| "The third woman had migraine but the attacks were not associated with HS." | 1.38 | Headache in three new cases of Harlequin syndrome with accompanying pharmacological comparison with migraine. ( Goadsby, PJ; Mathias, CJ; Viana, M, 2012) |
| "Although headache is a frequent side-effect, it is usually transient and glyceryl trinitrate does not seem to have any long-term adverse effects." | 1.35 | [The role of glyceryl trinitrate in the treatment of anal fissure]. ( Bursics, A; Takáts, K; Tóth, A, 2008) |
| "Headaches were experienced by 14 of 30 volunteers after a median (range) of 41 (4-120) min, persisting for 74 (30-176) min, with an intensity score of 19 (5-30) mm represented on a 100-mm linear visual analogue scale." | 1.31 | Systemic levels of glyceryl trinitrate following topical application to the anoderm do not correlate with the measured reduction in anal pressure. ( Barrett, DA; Jonas, M; Scholefield, JH; Shaw, PN, 2001) |
| "The diagnosis of temporal arteritis should be systematically suggested in patients over the age of 50 years, presenting with a marked inflammatory syndrome and recent-onset arterial disease." | 1.30 | [Horton's disease presenting as a myocardial infarction]. ( Bennis, A; Chraibi, N; Tahiri, A; Zahraoui, M, 1999) |
| "Thus, the headache is dependent on NO or other steps in the NO cascade." | 1.29 | Experimental headache in humans. ( Iversen, HK, 1995) |
| "Nitroglycerin was given sublingually to 27 patients." | 1.29 | Cervicogenic headache: responses to nitroglycerin, oxygen, ergotamine and morphine. ( Bovim, G; Sjaastad, O, 1993) |
| " Carefully designed dosing regimens and/or appropriate use of nitrate formulations (to include a nitrate-free period each day) will decrease or eliminate the problem of nitrate tolerance." | 1.29 | Therapy of angina pectoris with long-acting nitrates: which agent and when? ( Abrams, J, 1996) |
| "Nitroglycerin plasters were applied to the penis in 10 impotent men and the erectile effect assessed." | 1.28 | Non-invasive management of impotence with transcutaneous nitroglycerin. ( Bødker, A; Meyhoff, HH; Rosenkilde, P, 1992) |
| " Use of parenteral aminophylline to treat adverse events associated with intravenous dipyridamole brought complete relief of symptoms in 439 of 454 patients (96." | 1.28 | The safety of intravenous dipyridamole thallium myocardial perfusion imaging. Intravenous Dipyridamole Thallium Imaging Study Group. ( Kempthorne-Rawson, J; Ranhosky, A, 1990) |
| "Sixteen children with benign paroxysmal vertigo (BPV) are presented." | 1.27 | Benign paroxysmal vertigo in childhood. Diagnostic significance of vestibular examination and headache provocation tests. ( Balottin, U; Lanzi, G; Mira, E; Piacentino, G, 1984) |
| "Nitroglycerin is a volatile substance which evaporates from tablets if strict precautions are not taken." | 1.25 | Instability of nitroglycerin tablets. ( Mayer, GA, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 53 (33.76) | 18.7374 |
| 1990's | 28 (17.83) | 18.2507 |
| 2000's | 38 (24.20) | 29.6817 |
| 2010's | 31 (19.75) | 24.3611 |
| 2020's | 7 (4.46) | 2.80 |
| Authors | Studies |
|---|---|
| Bertels, Z | 1 |
| Mangutov, E | 1 |
| Conway, C | 1 |
| Siegersma, K | 1 |
| Asif, S | 1 |
| Shah, P | 1 |
| Huck, N | 1 |
| Tawfik, VL | 1 |
| Pradhan, AA | 1 |
| Uğurlu, YK | 1 |
| Enç, N | 1 |
| Karsan, N | 4 |
| Bose, RP | 1 |
| O'Daly, O | 1 |
| Zelaya, F | 1 |
| Goadsby, PJ | 6 |
| Akerman, S | 1 |
| Romero-Reyes, M | 1 |
| Bose, P | 1 |
| Hoffmann, JR | 1 |
| Holland, PR | 1 |
| Peréz-Rodríguez, A | 1 |
| Nagaraj, K | 1 |
| Bose, PR | 1 |
| He, Y | 1 |
| Shi, Z | 1 |
| Kashyap, Y | 1 |
| Messing, RO | 1 |
| Wang, ZJ | 1 |
| Bath, PM | 1 |
| Krishnan, K | 1 |
| Appleton, JP | 1 |
| Liu, R | 2 |
| Xu, H | 2 |
| Zhang, X | 1 |
| Wang, X | 1 |
| Yuan, Z | 1 |
| Sui, Z | 1 |
| Wang, D | 1 |
| Bi, K | 2 |
| Li, Q | 2 |
| Iardino, A | 1 |
| Garner, O | 1 |
| Lorusso, G | 1 |
| Lotta, F | 1 |
| Turin, SY | 1 |
| Li, DD | 1 |
| Vaca, EE | 1 |
| Fine, N | 1 |
| Marone, IM | 1 |
| De Logu, F | 1 |
| Nassini, R | 1 |
| De Carvalho Goncalves, M | 1 |
| Benemei, S | 1 |
| Ferreira, J | 1 |
| Jain, P | 1 |
| Li Puma, S | 1 |
| Bunnett, NW | 1 |
| Geppetti, P | 1 |
| Materazzi, S | 1 |
| Pradier, B | 1 |
| Shin, HB | 1 |
| Kim, DS | 1 |
| St Laurent, R | 1 |
| Lipscombe, D | 1 |
| Kauer, JA | 1 |
| Gazerani, P | 1 |
| Cairns, BE | 1 |
| Yassin, H | 1 |
| Yousefi, JT | 1 |
| Sherzaman, AR | 1 |
| Nedergaard, BS | 1 |
| Boldsen, SK | 1 |
| Tafoya, C | 1 |
| Singh, A | 1 |
| Ala, S | 1 |
| Saeedi, M | 1 |
| Hadianamrei, R | 1 |
| Ghorbanian, A | 1 |
| Yin, Y | 1 |
| Lv, C | 1 |
| Sun, W | 1 |
| He, B | 1 |
| Chen, X | 1 |
| Berry, SM | 1 |
| Barish, CF | 1 |
| Bhandari, R | 1 |
| Clark, G | 1 |
| Collins, GV | 1 |
| Howell, J | 1 |
| Pappas, JE | 1 |
| Riff, DS | 1 |
| Safdi, M | 1 |
| Yellowlees, A | 1 |
| Chen, L | 1 |
| Li, X | 1 |
| Todd, O | 1 |
| Wang, C | 1 |
| Jin, H | 1 |
| Du, J | 1 |
| Bucur, RC | 1 |
| Reid, LS | 1 |
| Hamilton, CJ | 1 |
| Cummings, SR | 1 |
| Jamal, SA | 1 |
| Oshinsky, ML | 1 |
| Murphy, AL | 1 |
| Hekierski, H | 1 |
| Cooper, M | 1 |
| Simon, BJ | 1 |
| Bütün, A | 2 |
| Nazıroğlu, M | 2 |
| Demirci, S | 1 |
| Çelik, Ö | 2 |
| Uğuz, AC | 2 |
| Pedersen, SH | 1 |
| Ramachandran, R | 1 |
| Amrutkar, DV | 1 |
| Petersen, S | 1 |
| Olesen, J | 14 |
| Jansen-Olesen, I | 2 |
| Abdel-Aleem, H | 1 |
| Abdel-Aleem, MA | 1 |
| Shaaban, OM | 1 |
| Liu, JW | 1 |
| Lin, CC | 1 |
| Kiu, KT | 1 |
| Wang, CY | 1 |
| Tam, KW | 1 |
| Mainardi, F | 1 |
| Zanchin, G | 1 |
| Maggioni, F | 1 |
| Medhi, B | 1 |
| Rao, RS | 1 |
| Prakash, A | 1 |
| Prakash, O | 1 |
| Kaman, L | 1 |
| Pandhi, P | 1 |
| Takáts, K | 1 |
| Tóth, A | 1 |
| Bursics, A | 1 |
| Kruuse, C | 1 |
| Iversen, HK | 10 |
| Edvinsson, L | 1 |
| Daugaard, D | 1 |
| Tfelt-Hansen, P | 4 |
| Thomsen, LL | 5 |
| Ratnasingham, K | 1 |
| Uzzaman, M | 1 |
| Andreani, SM | 1 |
| Light, D | 1 |
| Patel, B | 1 |
| SCHWARTZ, AM | 1 |
| Vanmolkot, F | 1 |
| de Hoon, J | 1 |
| Ashina, M | 3 |
| Dalgaard, P | 1 |
| Sajid, MS | 2 |
| Whitehouse, PA | 1 |
| Sains, P | 1 |
| Baig, MK | 2 |
| Viana, M | 1 |
| Mathias, CJ | 1 |
| Asghar, MS | 1 |
| Pérez-Legaz, J | 1 |
| Arroyo, A | 1 |
| Moya, P | 1 |
| Ruiz-Tovar, J | 1 |
| Frangi, A | 1 |
| Candela, F | 1 |
| Oliver, MI | 1 |
| Calpena, R | 1 |
| Svendsen, CB | 1 |
| Matzen, P | 1 |
| Noike, H | 1 |
| Iizuka, T | 1 |
| Matsumoto, J | 1 |
| Kaku, M | 1 |
| Yoshinaga, K | 1 |
| Aoyagi, K | 1 |
| Sakurai, T | 1 |
| Sugiyama, Y | 1 |
| Hitsumoto, T | 1 |
| Kanai, M | 1 |
| Ohsawa, H | 1 |
| Schleussner, E | 1 |
| Möller, A | 1 |
| Gross, W | 1 |
| Kähler, C | 1 |
| Möller, U | 1 |
| Richter, S | 1 |
| Seewald, HJ | 1 |
| Zahraoui, M | 1 |
| Bennis, A | 1 |
| Tahiri, A | 1 |
| Chraibi, N | 1 |
| Kowacs, F | 1 |
| Giffin, NJ | 1 |
| Putzki, N | 1 |
| Kaube, H | 1 |
| Stoeckelhuber, BM | 1 |
| Suttmann, I | 1 |
| Stoeckelhuber, M | 1 |
| Kueffer, G | 1 |
| Hirai, N | 1 |
| Kawano, H | 1 |
| Yasue, H | 1 |
| Shimomura, H | 1 |
| Miyamoto, S | 1 |
| Soejima, H | 1 |
| Kajiwara, I | 1 |
| Sakamoto, T | 1 |
| Yoshimura, M | 1 |
| Nakamura, H | 1 |
| Yodoi, J | 1 |
| Ogawa, H | 1 |
| Bujold, E | 1 |
| Boucher, M | 1 |
| Rinfret, D | 1 |
| Berman, S | 1 |
| Ferreira, E | 1 |
| Marquette, GP | 1 |
| DALSGARD-NIELSEN, T | 1 |
| LARSEN, E | 1 |
| BANG, E | 1 |
| DALSGAARD-NIELSEN, T | 1 |
| HERTZ, H | 1 |
| de Spirlet, M | 1 |
| Treluyer, JM | 1 |
| Chevret, S | 1 |
| Rey, E | 1 |
| Tournaire, M | 1 |
| Cabrol, D | 1 |
| Pons, G | 1 |
| Brzozowska, M | 1 |
| Kowalska-Koprek, U | 1 |
| Karowicz-Bilińska, A | 1 |
| Pajszczyk-Kieszkiewicz, T | 1 |
| de Tommaso, M | 1 |
| Libro, G | 1 |
| Guido, M | 1 |
| Difruscolo, O | 1 |
| Losito, L | 1 |
| Sardaro, M | 1 |
| Cerbo, R | 1 |
| Tvedskov, JF | 1 |
| Williams, P | 1 |
| Gibson, A | 1 |
| Jenkins, K | 1 |
| Peck, R | 1 |
| Hsi, DH | 1 |
| Roshandel, A | 1 |
| Singh, N | 1 |
| Szombathy, T | 1 |
| Meszaros, ZS | 1 |
| Juhász, G | 2 |
| Zsombók, T | 2 |
| Gonda, X | 2 |
| Bagdy, G | 2 |
| Thadani, U | 1 |
| Rodgers, T | 1 |
| Seet, RC | 1 |
| Lim, EC | 1 |
| Nagyne, N | 1 |
| Modosne, E | 1 |
| Nash, G | 1 |
| Rimple, J | 1 |
| Cheek, E | 1 |
| Kohl, FV | 1 |
| Balakumaran, K | 1 |
| Hugenholtz, PG | 1 |
| Tijssen, JG | 1 |
| Chadha, DR | 1 |
| Silber, S | 1 |
| Mira, E | 1 |
| Piacentino, G | 1 |
| Lanzi, G | 1 |
| Balottin, U | 1 |
| Sivertsen, E | 1 |
| Lehmann, HU | 1 |
| Hochrein, H | 1 |
| Raskin, NH | 1 |
| Hill, JA | 1 |
| Feldman, RL | 1 |
| Pepine, CJ | 1 |
| Conti, CR | 1 |
| Nattero, G | 4 |
| Iversen, H | 1 |
| Gorfine, SR | 1 |
| Bovim, G | 1 |
| Sjaastad, O | 1 |
| Nielsen, TH | 1 |
| Tegeler, CH | 1 |
| Davidai, G | 1 |
| Gengo, FM | 2 |
| Knappertz, VA | 1 |
| Troost, BT | 1 |
| Gabriel, H | 1 |
| Davis, RL | 1 |
| Abrams, J | 1 |
| Brennum, J | 1 |
| Schmetterer, L | 1 |
| Wolzt, M | 1 |
| Krejcy, K | 1 |
| Graselli, U | 1 |
| Findl, O | 1 |
| Eichler, HG | 1 |
| Singer, EA | 1 |
| Van Gelderen, EM | 1 |
| Saxena, PR | 1 |
| Herxheimer, A | 1 |
| Bacher, H | 1 |
| Mischinger, HJ | 1 |
| Werkgartner, G | 1 |
| Cerwenka, H | 1 |
| El-Shabrawi, A | 1 |
| Pfeifer, J | 1 |
| Schweiger, W | 1 |
| Hausken, T | 1 |
| Gilja, OH | 1 |
| Odegaard, S | 1 |
| Berstad, A | 1 |
| Fullerton, T | 1 |
| Komorowski-Swiatek, D | 1 |
| Forrest, A | 1 |
| Kiraly, C | 1 |
| Kiss, Z | 1 |
| Benczur, B | 1 |
| Timar, S | 1 |
| Brisinda, G | 1 |
| Maria, G | 1 |
| Bentivoglio, AR | 1 |
| Cassetta, E | 1 |
| Gui, D | 1 |
| Albanese, A | 1 |
| Salgado, G | 1 |
| Torrbedella, L | 1 |
| Berman, IR | 1 |
| Altomare, DF | 1 |
| Rinaldi, M | 1 |
| Milito, G | 1 |
| Arcanà, F | 1 |
| Spinelli, F | 1 |
| Nardelli, N | 1 |
| Scardigno, D | 1 |
| Pulvirenti-D'Urso, A | 1 |
| Bottini, C | 1 |
| Pescatori, M | 1 |
| Lovreglio, R | 1 |
| Hasegawa, H | 1 |
| Radley, S | 1 |
| Morton, DG | 1 |
| Dorricott, NJ | 1 |
| Campbell, DJ | 1 |
| Keighley, MR | 1 |
| Moya, RA | 1 |
| Moisa, CF | 1 |
| Morales, F | 1 |
| Wynter, H | 1 |
| Ali, A | 1 |
| Narancio, E | 1 |
| Christiansen, I | 1 |
| Santoro, A | 2 |
| Rovati, LC | 2 |
| Setnikar, I | 2 |
| Caplain, H | 2 |
| Gualano, V | 2 |
| Follet, M | 1 |
| Lambert, GA | 1 |
| Donaldson, C | 1 |
| Boers, PM | 1 |
| Zagami, AS | 1 |
| Bendtsen, L | 2 |
| Jensen, R | 2 |
| Schifter, S | 1 |
| Sakai, F | 1 |
| Meyjohann, D | 1 |
| Zell, L | 1 |
| Buchter, A | 1 |
| Hawkes, ND | 1 |
| Richardson, C | 1 |
| Ch'Ng, CL | 1 |
| Green, JT | 1 |
| Evans, BK | 1 |
| Williams, J | 1 |
| Rhodes, P | 1 |
| Rhodes, J | 1 |
| Swift, GL | 1 |
| Thomas, GA | 1 |
| Hawthorne, AB | 1 |
| Kingham, JG | 1 |
| Mayberry, JF | 1 |
| Jonas, M | 1 |
| Barrett, DA | 1 |
| Shaw, PN | 1 |
| Scholefield, JH | 1 |
| Hall, R | 1 |
| Chong, C | 1 |
| Behrends, S | 1 |
| Knyihár-Csillik, E | 1 |
| Kempfert, J | 1 |
| Scholz, H | 1 |
| Csillik, B | 1 |
| Vécsei, L | 1 |
| Davis, DG | 1 |
| Brown, PM | 1 |
| Facchinetti, F | 1 |
| Sgarbi, L | 1 |
| Piccinini, F | 1 |
| Volpe, A | 1 |
| Kocher, HM | 1 |
| Steward, M | 1 |
| Leather, AJ | 1 |
| Cullen, PT | 1 |
| Hansen, MS | 1 |
| Sorge, F | 1 |
| Steardo, L | 1 |
| Di Furia, U | 1 |
| Florio, C | 1 |
| Di Pietro, G | 1 |
| Orzalesi, B | 1 |
| Steinke, L | 1 |
| Kiskery, L | 1 |
| Davidov, ME | 1 |
| Mroczek, WJ | 1 |
| Perli, PD | 1 |
| Birka, EA | 1 |
| Copelan, HW | 1 |
| Heyck, H | 1 |
| Silverman, AP | 1 |
| Hannerz, J | 1 |
| Greitz, D | 1 |
| Kośmicki, M | 2 |
| Sadowski, Z | 2 |
| Meyhoff, HH | 1 |
| Rosenkilde, P | 1 |
| Bødker, A | 1 |
| Shively, M | 1 |
| Riegel, B | 2 |
| Scardi, S | 1 |
| Camerini, F | 2 |
| Pandullo, C | 1 |
| Pollavini, G | 1 |
| Ranhosky, A | 1 |
| Kempthorne-Rawson, J | 1 |
| Takayanagi, K | 1 |
| Fujito, T | 1 |
| Morooka, S | 1 |
| Takabatake, Y | 1 |
| Nakamura, Y | 1 |
| Waters, DD | 1 |
| Juneau, M | 1 |
| Gossard, D | 1 |
| Choquette, G | 1 |
| Brien, M | 1 |
| Emanuelsson, H | 1 |
| Ake, H | 1 |
| Kristi, M | 1 |
| Arina, R | 1 |
| Frishman, WH | 1 |
| Giles, T | 1 |
| Greenberg, S | 1 |
| Heiman, M | 1 |
| Raffidal, L | 1 |
| Soberman, J | 1 |
| Laifer, L | 1 |
| Nadelmann, J | 1 |
| Lazar, E | 1 |
| Strom, J | 1 |
| Wright, A | 1 |
| Hecker, JF | 1 |
| Lewis, GB | 1 |
| Fletcher, A | 1 |
| McLoone, P | 1 |
| Bulpitt, C | 1 |
| McAllister, A | 1 |
| Mosberg, H | 1 |
| Settlage, JA | 1 |
| Steiner, JA | 1 |
| Neuhaus, R | 1 |
| Johnen, R | 1 |
| Vydra, L | 1 |
| Solbach, C | 1 |
| Campisi, D | 1 |
| Paterna, S | 1 |
| Bivona, A | 1 |
| Valenza, M | 1 |
| Cannistraro, F | 1 |
| Montaina, G | 1 |
| Martino, S | 1 |
| Sicuteri, F | 1 |
| Del Bene, E | 1 |
| Poggioni, M | 1 |
| Bonazzi, A | 1 |
| Luke, R | 1 |
| Sharpe, N | 1 |
| Coxon, R | 1 |
| Heywood, G | 1 |
| Jackson, W | 1 |
| Kennedy, A | 1 |
| Gjesdal, K | 1 |
| Bille, S | 1 |
| Bredesen, JE | 1 |
| Bjørge, E | 1 |
| Halvorsen, B | 1 |
| Langseth, K | 1 |
| Lunde, PK | 1 |
| Silvertssen, E | 1 |
| Hubner, PJ | 1 |
| Jones, PR | 1 |
| Galer, IA | 1 |
| Ekbom, K | 5 |
| Cohn, PF | 1 |
| Gorlin, R | 1 |
| Mayer, GA | 1 |
| Contractor, AM | 1 |
| Snyder, JM | 1 |
| Fletcher, HP | 1 |
| Shangraw, RF | 1 |
| Angelino, PF | 1 |
| Bobba, P | 1 |
| Caturelli, G | 1 |
| Cherchi, A | 1 |
| Giovannelli, CA | 1 |
| Maggi, GC | 1 |
| de Sépibus, G | 1 |
| Horwitz, LD | 1 |
| Trainor, DC | 1 |
| Jones, RC | 1 |
| Lund, RP | 1 |
| Häggendal, J | 1 |
| Johnsson, G | 1 |
| Zhmurkin, VP | 1 |
| Campus, S | 2 |
| Rappelli, A | 2 |
| Fabris, F | 2 |
| Gastaldi, L | 3 |
| Gai, V | 3 |
| Piazza, A | 1 |
| Lindahl, J | 1 |
| Hansen, HJ | 1 |
| Drewes, VM | 1 |
| Bogaert, MG | 1 |
| Rosseel, MT | 1 |
| Belpaire, FM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Habituation of the Nociceptive Blink Reflex in Experimentally Induced Migraine Attack: a Cross-over, Randomized Controlled Study[NCT05718310] | 22 participants (Anticipated) | Interventional | 2022-11-01 | Recruiting | |||
| Assessing and Comparing the Effect of Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers.[NCT02801305] | Phase 2 | 90 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| Randomized Controlled Trial Comparing the Efficacy of Polyethylene Glycol Alone and Polyethylene Glycol Combined With Topical Diltiazem in Treating Anal fissure in Children[NCT02419534] | Phase 4 | 46 participants (Anticipated) | Interventional | 2014-11-30 | Recruiting | ||
| A Randomized. Double-blind, Placebo-controlled, Multi-national Study to Determine the Effect of Cellegesic Nitroglycerin Ointment 0.4% (Cellegesic) on the Pain Associated With a Chronic Anal Fissure[NCT00522041] | Phase 3 | 248 participants (Actual) | Interventional | 2007-08-31 | Completed | ||
| Nitrates and Bone Turnover (NABT): Trial to Select the Best Nitrate Preparation[NCT01387672] | Phase 3 | 265 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| Safety and Efficacy of Non-invasive Vagus Nerve Stimulation in the Treatment of Headache in Subarachnoid Hemorrhage[NCT04126408] | 40 participants (Actual) | Interventional | 2020-01-13 | Completed | |||
| The Effect Of Transcutaneous Auricular Vagus Nerve Stimulation On Sports Performance And Physiological Parameters In Healthy Young Individuals: Randomized, Double-Blind Study[NCT04768738] | 46 participants (Actual) | Interventional | 2020-02-01 | Completed | |||
| Comparative Evaluation of MEBO Ointment and Topical Diltiazem Ointment in the Treatment of Acute Anal Fissure: a Randomized Clinical Trial[NCT04153032] | Phase 2 | 183 participants (Anticipated) | Interventional | 2019-12-01 | Recruiting | ||
| Effects of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure[NCT04320498] | Phase 4 | 41 participants (Actual) | Interventional | 2019-01-01 | Completed | ||
| Perianal vs Endoanal Application of Glyceryl Trinitrate 0.4% Ointment in the Treatment of Chronic Anal Fissure: Results of a Randomized Controlled Trial.[NCT01132391] | Phase 3 | 60 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| Understanding the Role of the External Carotid Artery in the Pathophysiology of Migraine Pain[NCT03026101] | 20 participants (Anticipated) | Interventional | 2017-01-31 | Enrolling by invitation | |||
| Idiopathic Hypertensive Anal Canal: a Place of Internal Sphincterotomy[NCT00927849] | 63 participants (Actual) | Interventional | 2002-09-30 | Completed | |||
| Botulin Toxin Versus Isosorbidedinitrate Ointment in Treatment Anal Fissure; A Prospective, Blinded, Randomized Trial[NCT00827736] | Phase 4 | 73 participants (Actual) | Interventional | 2002-06-30 | Completed | ||
| Absorption and Pharmacokinetics of Nitroglycerin as a Tablet or in the Form of Rapidly Degradable Capsule in Young Healthy[NCT03777605] | Phase 4 | 10 participants (Anticipated) | Interventional | 2018-12-23 | Not yet recruiting | ||
| Safety and Tolerability of Topical Nitroglycerin to Dilate the Radial Artery Prior to Transradial Coronary Angiography[NCT05239013] | Early Phase 1 | 20 participants (Anticipated) | Interventional | 2022-05-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale at Baseline and on Days 14 through 18. The average pain rating on Days 14 through 18 was calculated and used to determine the change from Baseline. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. A negative change score indicated improvement." (NCT00522041)
Timeframe: Baseline to Day 18
| Intervention | Units on a scale (Mean) |
|---|---|
| Cellegesic (Nitroglycerin 0.4%) | -40.4 |
| Placebo | -34.9 |
"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale at Baseline and on Days 14 through 18. The average pain rating on Days 14 through 18 was calculated. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. A responder was defined as a participant with either a ≥ 50% decrease or a ≥ 10 mm decrease from Baseline in the 24 hour average pain intensity averaged over Days 14 to 18." (NCT00522041)
Timeframe: Baseline to Day 18
| Intervention | Percentage of responders (Number) | |
|---|---|---|
| ≥ 50% decrease | ≥ 10 mm decrease | |
| Cellegisic (Nitroglycerin 0.4%) | 72.4 | 88.6 |
| Placebo | 64.5 | 85.5 |
"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale (VAS) at Baseline and on each of the 21 treatment days of the study. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. Improvement was defined as either a ≥ 50% decrease or a ≥ 10 mm decrease from Baseline in rated pain intensity." (NCT00522041)
Timeframe: Baseline to Day 21
| Intervention | Days (Mean) | |
|---|---|---|
| ≥ 50% decrease | ≥ 10 mm decrease | |
| Cellegisic (Nitroglycerin 0.4%) | 10.7 | 6.1 |
| Placebo | 13.2 | 7.2 |
"Markers of Bone Formation:~Serum Procollagen type 1 amino- terminal propeptide (P1NP)~Serum Osteocalcin (OC)~Serum Bone-specific alkaline phosphatase (BALP)~Markers of Bone Resorption:~- Serum C-telopeptides of collagen cross-links (CTX)" (NCT01387672)
Timeframe: 3 months
| Intervention | Percent change from baseline (Mean) | |||
|---|---|---|---|---|
| P1NP | OC | BALP | CTX | |
| 0.3 Sublingual (Nitrostat 1) - Treatment Arm 4 | -6.126 | 1.046 | -7.000 | -0.666 |
| 0.6 Sublingual (Nitrostat 2) - Treatment Arm 5 | 2.941 | 1.033 | -3.686 | -1.380 |
| ISMO - Treatment Arm 1 | -4.627 | -3.244 | -5.023 | -5.844 |
| Ointment (Nitrol) - Treatment Arm 3 | -4.297 | -4.481 | -7.426 | -9.699 |
| Patch (Nitro-Dur) - Treatment Arm 2 | -0.405 | 3.796 | -0.541 | -1.025 |
| Placebo Ointment - Treatment Arm 6 | -1.635 | 4.247 | -1.648 | -1.783 |
"Severity of headaches. Subjects recorded the severity of headaches upon awakening every day during the run-in phase using a visual analogue scale (VAS). The scale is represented by a line (continuum) 10 cm long. Subjects were asked to make a vertical line along the continuum to indicate the severity of their headache each morning upon awakening. The score is recorded in cm from 0 to 10. A vertical line marked at 0 means no headache (score recorded = 0), a vertical line marked at 10 means a terrible headache (score recorded = 10)." (NCT01387672)
Timeframe: Run-in phase - 2 days
| Intervention | score on a scale (Mean) | ||||
|---|---|---|---|---|---|
| ISMO | Patch | Ointment | 0.3 Sublingual | 0.6 Sublingual | |
| Run-in Phase | 2.1 | 3.1 | 1.5 | 0.36 | 0.6 |
using a visual analog scale (VAS) with which each patients noted the severity of pain at each evaluated time using a linear between zero (no pain) and 10 ( severe pain) (NCT00927849)
Timeframe: one year after the procedure
| Intervention | score in scale (Mean) |
|---|---|
| Surgical Group Lateral Sphincterotomy | 4.16 |
| Glycein Trinitrate Group | 4.18 |
| Botilinium Toxin Injection | 4.2 |
17 reviews available for nitroglycerin and Headache
| Article | Year |
|---|---|
Neuroimaging in the pre-ictal or premonitory phase of migraine: a narrative review.
Topics: Brain; Diffusion Tensor Imaging; Headache; Humans; Migraine Disorders; Neuroimaging; Nitroglycerin; | 2023 |
Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke.
Topics: Acute Disease; Arginine; Brain Ischemia; Enzyme Inhibitors; Headache; Humans; Nitric Oxide Donors; N | 2017 |
Cardiac Memory: A Case Report and Review of the Literature.
Topics: Aged; Amlodipine; Arrhythmias, Cardiac; Aspirin; Bundle-Branch Block; Chest Pain; Electrocardiograph | 2019 |
Nitroglycerin for management of retained placenta.
Topics: Administration, Sublingual; Female; Headache; Humans; Nitroglycerin; Oxytocics; Oxytocin; Placenta, | 2015 |
Effect of Glyceryl Trinitrate Ointment on Pain Control After Hemorrhoidectomy: A Meta-analysis of Randomized Controlled Trials.
Topics: Analgesics, Non-Narcotic; Headache; Hemorrhoidectomy; Hemorrhoids; Humans; Nitroglycerin; Ointments; | 2016 |
Sublingual nitroglycerin powder (GoNitro).
Topics: Administration, Sublingual; Angina Pectoris; Drug Compounding; Headache; Humans; Nitroglycerin; Powd | 2016 |
Recent advances in the pharmacotherapy of chronic anal fissure: an update.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel | 2008 |
Recent advances in the pharmacotherapy of chronic anal fissure: an update.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel | 2008 |
Recent advances in the pharmacotherapy of chronic anal fissure: an update.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel | 2008 |
Recent advances in the pharmacotherapy of chronic anal fissure: an update.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel | 2008 |
Nitric oxide-related drug targets in headache.
Topics: Cyclic GMP; Headache; Humans; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Phosphodiesterase In | 2010 |
Meta-analysis of the use of glyceryl trinitrate ointment after haemorrhoidectomy as an analgesic and in promoting wound healing.
Topics: Analgesics; Headache; Hemorrhoids; Humans; Nitroglycerin; Ointments; Pain Measurement; Pain, Postope | 2010 |
Systematic review of the use of topical diltiazem compared with glyceryltrinitrate for the nonoperative management of chronic anal fissure.
Topics: Administration, Topical; Chronic Disease; Diltiazem; Fissure in Ano; Headache; Humans; Nitroglycerin | 2013 |
Effects of glyceryl trinitrate and calcitonin gene-related peptide on BOLD signal and arterial diameter: methodological studies by fMRI and MRA.
Topics: Acetazolamide; Adolescent; Adult; Anticonvulsants; Brain; Calcitonin Gene-Related Peptide; Cerebral | 2012 |
[Treatment of chronic anal fissure with topically applied nitroglycerin ointment. A systematic review of evidence-based results].
Topics: Administration, Topical; Anal Canal; Chronic Disease; Evidence-Based Medicine; Fissure in Ano; Heada | 2002 |
Side effects of using nitrates to treat angina.
Topics: Angina Pectoris; Coronary Disease; Drug Interactions; Headache; Humans; Isosorbide Dinitrate; Nitrat | 2006 |
The efficacy of diltiazem and glyceryltrinitrate for the medical management of chronic anal fissure: a meta-analysis.
Topics: Chronic Disease; Diltiazem; Fissure in Ano; Headache; Humans; Nitroglycerin; Prospective Studies; Ra | 2008 |
Chemical headaches.
Topics: Animals; Ethanol; Headache; Humans; Nitrites; Nitroglycerin; Phenethylamines; Sodium Glutamate; Tyra | 1981 |
Nitric oxide is a key molecule in migraine and other vascular headaches.
Topics: Amino Acid Oxidoreductases; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Headache; | 1994 |
Mechanism of action and clinical use of nitroglycerin.
Topics: Angina Pectoris; Blood Pressure; Coronary Circulation; Coronary Disease; Coronary Vessels; Drug Stab | 1973 |
60 trials available for nitroglycerin and Headache
| Article | Year |
|---|---|
Regional cerebral perfusion during the premonitory phase of triggered migraine: A double-blind randomized placebo-controlled functional imaging study using pseudo-continuous arterial spin labeling.
Topics: Brain; Cerebrovascular Circulation; Headache; Humans; Magnetic Resonance Imaging; Migraine Disorders | 2023 |
Nitroglycerin Ointment for Reducing the Rate of Mastectomy Flap Necrosis in Immediate Implant-Based Breast Reconstruction.
Topics: Administration, Cutaneous; Adult; Breast; Breast Implantation; Breast Neoplasms; Female; Follow-Up S | 2018 |
Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double-blind trial.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Diltiazem; Dou | 2012 |
Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double-blind trial.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Diltiazem; Dou | 2012 |
Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double-blind trial.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Diltiazem; Dou | 2012 |
Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double-blind trial.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Diltiazem; Dou | 2012 |
Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Double-Blind Method; Female; Fissu | 2013 |
Nitrates and bone turnover (NABT) - trial to select the best nitrate preparation: study protocol for a randomized controlled trial.
Topics: Administration, Cutaneous; Administration, Sublingual; Age Factors; Biomarkers; Bone and Bones; Bone | 2013 |
Calcitonin gene-related peptide (CGRP) levels during glyceryl trinitrate (GTN)-induced headache in healthy volunteers.
Topics: Adult; Calcitonin Gene-Related Peptide; Cross-Over Studies; Female; Headache; Humans; Male; Neuropep | 2010 |
No effect of pure oxygen inhalation on headache induced by glyceryl trinitrate.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Headache; Humans; Male; Nitric Oxide; Nitric | 2010 |
Lack of correlation between vasodilatation and pharmacologically induced immediate headache in healthy subjects.
Topics: Adolescent; Adult; Blood Flow Velocity; Calcitonin Gene-Related Peptide; Carbachol; Cholinergic Agon | 2011 |
Perianal versus endoanal application of glyceryl trinitrate 0.4% ointment in the treatment of chronic anal fissure: results of a randomized controlled trial. Is this the solution to the headaches?
Topics: Adolescent; Adult; Aged; Chronic Disease; Drug Administration Schedule; Female; Fissure in Ano; Foll | 2012 |
Maternal and fetal side effects of tocolysis using transdermal nitroglycerin or intravenous fenoterol combined with magnesium sulfate.
Topics: Administration, Cutaneous; Adolescent; Adult; Blood Pressure; Drug Therapy, Combination; Female; Fen | 2003 |
Nociceptive-specific blink reflex and glyceryl trinitrate infusion in healthy volunteers.
Topics: Adult; Area Under Curve; Blinking; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Fe | 2003 |
Attenuation of nitrate tolerance and oxidative stress by an angiotensin II receptor blocker in patients with coronary spastic angina.
Topics: Administration, Cutaneous; Aged; Angina Pectoris; Angiotensin Receptor Antagonists; Benzimidazoles; | 2003 |
Sublingual nitroglycerin versus placebo as a tocolytic for external cephalic version: a randomized controlled trial in parous women.
Topics: Administration, Sublingual; Adult; Double-Blind Method; Female; Headache; Humans; Nitroglycerin; Par | 2003 |
Tocolytic effects of intravenous nitroglycerin.
Topics: Adult; Clinical Protocols; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fetal Bloo | 2004 |
[Effect of long-term therapy with transdermal patches releasing glyceryl trinitrate (GTN) used in pregnant hypertensive women on stabilisation of blood pressure and on the condition of the newborn infant].
Topics: Administration, Cutaneous; Adult; Blood Pressure; Dose-Response Relationship, Drug; Drug Administrat | 2004 |
The effect of propranolol on glyceryltrinitrate-induced headache and arterial response.
Topics: Adult; Brain; Cerebrovascular Circulation; Cross-Over Studies; Female; Headache; Humans; Male; Middl | 2004 |
Molsidomine, an effective long-acting anti-anginal drug.
Topics: Angina Pectoris; Clinical Trials as Topic; Headache; Heart Ventricles; Humans; Male; Molsidomine; Ni | 1983 |
[Nitrate tolerance: pro and con].
Topics: Angina Pectoris; Cardiac Output; Clinical Trials as Topic; Drug Administration Schedule; Drug Tolera | 1984 |
Randomized double-blind comparison of nifedipine and isosorbide dinitrate in patients with coronary arterial spasm.
Topics: Adult; Aged; Angina Pectoris; Angiocardiography; Clinical Trials as Topic; Coronary Vasospasm; Doubl | 1982 |
Nitroglycerin-induced headache is not dependent on histamine release: support for a direct nociceptive action of nitric oxide.
Topics: Analysis of Variance; Cross-Over Studies; Double-Blind Method; Headache; Hemodynamics; Histamine Rel | 1994 |
Lack of tolerance of headache and radial artery diameter during a 7 hour intravenous infusion of nitroglycerin.
Topics: Adult; Double-Blind Method; Female; Headache; Heart Rate; Humans; Infusions, Intravenous; Male; Nitr | 1993 |
Effect of a nitric oxide donor (glyceryl trinitrate) on nociceptive thresholds in man.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Headache; Hemodynamics; Humans; Male; Nitric | 1996 |
Cerebral and ocular hemodynamic effects of sumatriptan in the nitroglycerin headache model.
Topics: Adult; Analysis of Variance; Blood Flow Velocity; Cerebrovascular Circulation; Double-Blind Method; | 1996 |
Headache induced by a nitric oxide donor (nitroglycerin) responds to sumatriptan. A human model for development of migraine drugs.
Topics: Adult; Blood Flow Velocity; Brain; Cross-Over Studies; Double-Blind Method; Female; Headache; Humans | 1996 |
Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy?
Topics: Acute Disease; Administration, Rectal; Administration, Topical; Adult; Anal Canal; Anesthetics, Loca | 1997 |
Flow across the human pylorus soon after ingestion of food, studied with duplex sonography. Effect of glyceryl trinitrate.
Topics: Adult; Eating; Food; Gastric Emptying; Gastrointestinal Motility; Headache; Humans; Male; Nausea; Ni | 1998 |
The pharmacodynamics of sumatriptan in nitroglycerin-induced headache.
Topics: Adult; Analysis of Variance; Area Under Curve; Brain; Cerebral Arteries; Electrocardiography; Headac | 1999 |
A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Anal Canal; Botulinum Toxins, Type A; Chronic Disease; Cross-Over St | 1999 |
A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Anal Canal; Botulinum Toxins, Type A; Chronic Disease; Cross-Over St | 1999 |
A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Anal Canal; Botulinum Toxins, Type A; Chronic Disease; Cross-Over St | 1999 |
A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Anal Canal; Botulinum Toxins, Type A; Chronic Disease; Cross-Over St | 1999 |
Glyceryl trinitrate for chronic anal fissure--healing or headache? Results of a multicenter, randomized, placebo-controled, double-blind trial.
Topics: Adult; Anal Canal; Blood Flow Velocity; Chronic Disease; Double-Blind Method; Female; Fissure in Ano | 2000 |
Audit of topical glyceryl trinitrate for treatment of fissure-in-ano.
Topics: Acute Disease; Adult; Aged; Chronic Disease; Female; Fissure in Ano; Follow-Up Studies; Headache; Hu | 2000 |
Transdermal glyceryl trinitrate in the management of primary dysmenorrhea.
Topics: Administration, Cutaneous; Cross-Over Studies; Double-Blind Method; Dysmenorrhea; Female; Headache; | 2000 |
Headache characteristics during the development of tolerance to nitrates: pathophysiological implications.
Topics: Administration, Oral; Adult; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Female; Headac | 2000 |
Bioavailability and pharmacokinetic profile of glyceryl trinitrate and of glyceryl dinitrates during application of a new glyceryl trinitrate transdermal patch.
Topics: Adhesiveness; Administration, Cutaneous; Adult; Area Under Curve; Biological Availability; Cross-Ove | 2000 |
Plasma levels of glyceryl trinitrate and dinitrates during application of three strengths of a new glyceryl trinitrate transdermal patch.
Topics: Adhesiveness; Administration, Cutaneous; Adult; Area Under Curve; Biological Availability; Cross-Ove | 2000 |
Possible mechanisms of glyceryl-trinitrate-induced immediate headache in patients with chronic tension-type headache.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Headache; Humans; Infusions, Intravenous; Ma | 2000 |
Enteric-release glyceryl trinitrate in active Crohn's disease: a randomized, double-blind, placebo-controlled trial.
Topics: Administration, Oral; Adult; Crohn Disease; Dizziness; Double-Blind Method; Exanthema; Female; Flush | 2001 |
A double-blind, parallel-group study of amlodipine versus long-acting nitrate in the management of elderly patients with stable angina.
Topics: Aged; Aged, 80 and over; Amlodipine; Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Dela | 2001 |
A comparison of glyceryl trinitrate with diclofenac for the treatment of primary dysmenorrhea: an open, randomized, cross-over trial.
Topics: Administration, Cutaneous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diclo | 2002 |
Randomized clinical trial assessing the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissure.
Topics: Adult; Aged; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Female; Fissure in Ano; Foll | 2002 |
Application site for nitroglycerin ointment.
Topics: Administration, Topical; Adult; Analysis of Variance; Ankle; Blood Pressure; Clinical Trials as Topi | 1978 |
Effect of sustained release nitroglycerin capsules on anginal frequency and exercise capacity: a double-blind evaluation.
Topics: Administration, Oral; Angina Pectoris; Capsules; Delayed-Action Preparations; Double-Blind Method; D | 1977 |
[Evaluation of clinical effectiveness and adverse effects of Polnitrin].
Topics: Administration, Buccal; Administration, Sublingual; Adult; Biological Availability; Coronary Disease | 1992 |
N-acetylcysteine enhances nitroglycerin-induced headache and cranial arterial responses.
Topics: Acetylcysteine; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Sc | 1992 |
Effect of nitroglycerin ointment placement on headache and flushing in healthy subjects.
Topics: Administration, Cutaneous; Adult; Analysis of Variance; Angina Pectoris; Arm; Female; Flushing; Head | 1991 |
Efficacy of continuous and intermittent transdermal treatment with nitroglycerin in effort angina pectoris: a multicentric study. The Collaborative Nitro Group.
Topics: Aged; Angina Pectoris; Double-Blind Method; Drug Administration Schedule; Exercise; Exercise Test; F | 1991 |
Limited usefulness of intermittent nitroglycerin patches in stable angina.
Topics: Administration, Cutaneous; Adult; Aged; Angina Pectoris; Electrocardiography; Exercise Test; Female; | 1989 |
Effects of diltiazem and isosorbide-5-mononitrate, alone and in combination, on patients with stable angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Diltiazem; Double-Blind Method; Drug Therapy, Combinat | 1989 |
Sustained high-dose nitroglycerin transcutaneous patch therapy in angina pectoris: evidence for attenuation of effect over time.
Topics: Administration, Cutaneous; Administration, Sublingual; Adult; Aged; Angina Pectoris; Blood Pressure; | 1989 |
Use of transdermal glyceryl trinitrate to reduce failure of intravenous infusion due to phlebitis and extravasation.
Topics: Administration, Topical; Clinical Trials as Topic; Double-Blind Method; Extravasation of Diagnostic | 1985 |
Quality of life on angina therapy: a randomised controlled trial of transdermal glyceryl trinitrate against placebo.
Topics: Administration, Cutaneous; Adult; Aged; Angina Pectoris; Chronic Disease; Clinical Trials as Topic; | 1988 |
Plasma levels of nitroglycerin generated by three nitroglycerin patch preparations, Nitradisc, Transiderm-Nitro and Nitro-Dur and one ointment formulation, Nitrobid.
Topics: Administration, Topical; Adolescent; Adult; Delayed-Action Preparations; Dizziness; Drug Evaluation; | 1986 |
Comparative clinical trial of isosorbide 5-mononitrate and sustained-release isosorbide dinitrate in ischaemic heart disease.
Topics: Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Delayed-Action Preparat | 1986 |
Transdermal nitroglycerin in angina pectoris: efficacy of intermittent application.
Topics: Administration, Cutaneous; Adult; Aged; Angina Pectoris; Exercise Test; Headache; Humans; Male; Midd | 1987 |
Effect of nitroglycerin ointment placement on the severity of headache and flushing in patients with cardiac disease.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Coronary Disease; Female; Flu | 1988 |
[Evaluation of the clinical effectiveness and adverse effects of transdermal nitroglycerin in the form of plasters in patients with stable coronary disease].
Topics: Administration, Cutaneous; Adult; Aged; Clinical Trials as Topic; Coronary Disease; Female; Headache | 1988 |
Assessment of dermal glyceryl trinitrate and isosorbide dinitrate for patients with angina pectoris.
Topics: Administration, Topical; Adult; Angina Pectoris; Clinical Trials as Topic; Double-Blind Method; Exer | 1985 |
Development and evaluation of an inhalation aerosol of nitroglycerin.
Topics: Administration, Intranasal; Administration, Oral; Adult; Aerosol Propellants; Aerosols; Analysis of | 1974 |
Nifedipine in angina pectoris. A multicentric clinical trial.
Topics: Adult; Aged; Analysis of Variance; Angina Pectoris; Clinical Trials as Topic; Dicarboxylic Acids; Dr | 1974 |
The nitroglycerine ointment test--a double-blind examination.
Topics: Clinical Trials as Topic; Ergotamine; Female; Headache; Humans; Male; Methods; Migraine Disorders; N | 1970 |
Metabolism of nitroglycerin in man: influence of phenobarbital.
Topics: Clinical Trials as Topic; Enzyme Induction; Headache; Humans; Male; Nausea; Nitrates; Nitroglycerin; | 1971 |
80 other studies available for nitroglycerin and Headache
| Article | Year |
|---|---|
Migraine and peripheral pain models show differential alterations in neuronal complexity.
Topics: Animals; Complex Regional Pain Syndromes; Cortical Spreading Depression; Disease Models, Animal; Hea | 2022 |
The effect of local cold compresses for nitroglycerin-induced headache: An observational pretest-posttest study.
Topics: Blood Pressure; Headache; Humans; Nitroglycerin; Pain; Quality of Life | 2023 |
Therapeutic targeting of nitroglycerin-mediated trigeminovascular neuronal hypersensitivity predicts clinical outcomes of migraine abortives.
Topics: Animals; Headache; Hyperalgesia; Migraine Disorders; Neurons; Nitroglycerin; Rats | 2021 |
The migraine postdrome: Spontaneous and triggered phenotypes.
Topics: Adolescent; Adult; Fatigue; Female; Headache; Humans; Male; Middle Aged; Migraine Disorders; Nausea; | 2021 |
Protein kinase Cδ as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice.
Topics: Animals; Disease Models, Animal; Headache; Hyperalgesia; Mice; Migraine Disorders; Nitroglycerin; Pr | 2021 |
Metabolomics Strategy Using High Resolution Mass Spectrometry Reveals Novel Biomarkers and Pain-Relief Effect of Traditional Chinese Medicine Prescription Wu-Zhu-Yu Decoction Acting on Headache Modelling Rats.
Topics: Animals; Biomarkers; Chromatography, Liquid; Discriminant Analysis; Disease Models, Animal; Drugs, C | 2017 |
Headache in an HIV-Positive Patient: Dangerous Interaction.
Topics: Adult; Anti-HIV Agents; Anticoagulants; Cilostazol; Cytochrome P-450 CYP3A Inhibitors; Dideoxynucleo | 2018 |
TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice.
Topics: Aldehyde Dehydrogenase, Mitochondrial; Animals; Cell Body; Headache; Hyperalgesia; Male; Mice; Mice, | 2018 |
Long-Term Depression Induced by Optogenetically Driven Nociceptive Inputs to Trigeminal Nucleus Caudalis or Headache Triggers.
Topics: Afferent Pathways; Animals; Central Nervous System Sensitization; Excitatory Postsynaptic Potentials | 2018 |
Amplification of glyceryl trinitrate-induced headache features by noxious craniofacial stimuli in pain-free healthy humans.
Topics: Adult; Capsaicin; Female; Head; Headache; Healthy Volunteers; Humans; Male; Nitroglycerin; Nocicepti | 2019 |
Simultaneous determination of three alkaloids, four ginsenosides and limonin in the plasma of normal and headache rats after oral administration of Wu-Zhu-Yu decoction by a novel ultra fast liquid chromatography-tandem mass spectrometry method: applicatio
Topics: Alkaloids; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Drug Stability; Drugs, C | 2013 |
A clinical manifestation-based prediction of haemodynamic patterns of orthostatic intolerance in children: a multi-centre study.
Topics: Adolescent; Blood Pressure; Chest Pain; Child; Child, Preschool; Discriminant Analysis; Dizziness; F | 2014 |
Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia.
Topics: Animals; Dura Mater; gamma-Aminobutyric Acid; Glutamic Acid; Headache; Hyperalgesia; Male; Microdial | 2014 |
Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia.
Topics: Animals; Dura Mater; gamma-Aminobutyric Acid; Glutamic Acid; Headache; Hyperalgesia; Male; Microdial | 2014 |
Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia.
Topics: Animals; Dura Mater; gamma-Aminobutyric Acid; Glutamic Acid; Headache; Hyperalgesia; Male; Microdial | 2014 |
Noninvasive vagus nerve stimulation as treatment for trigeminal allodynia.
Topics: Animals; Dura Mater; gamma-Aminobutyric Acid; Glutamic Acid; Headache; Hyperalgesia; Male; Microdial | 2014 |
Riboflavin and vitamin E increase brain calcium and antioxidants, and microsomal calcium-ATP-ase values in rat headache models induced by glyceryl trinitrate.
Topics: Animals; Antioxidants; Ascorbic Acid; beta Carotene; Brain; Calcium; Calcium-Transporting ATPases; D | 2015 |
Protective effects of riboflavin and selenium on brain microsomal Ca2+-ATPase and oxidative damage caused by glyceryl trinitrate in a rat headache model.
Topics: Animals; Brain; Calcium-Transporting ATPases; Disease Models, Animal; Female; Headache; Microsomes; | 2015 |
Mechanisms of glyceryl trinitrate provoked mast cell degranulation.
Topics: Animals; Cell Degranulation; Headache; Male; Mast Cells; Nitric Oxide Donors; Nitroglycerin; Rats; R | 2015 |
Hemicrania Continua-Like Headache Related to Transdermal Nitroglycerine Therapy.
Topics: Administration, Cutaneous; Aged; Headache; Humans; Male; Nitroglycerin; Paroxysmal Hemicrania; Vasod | 2017 |
[The role of glyceryl trinitrate in the treatment of anal fissure].
Topics: Acute Disease; Adult; Anal Canal; Chronic Disease; Diagnosis, Differential; Female; Fissure in Ano; | 2008 |
The cause, relief and prevention of headaches arising from contact with dynamite.
Topics: Biomedical Research; Explosive Agents; Headache; Humans; Nitrites; Nitroglycerin | 1946 |
Comments on 'Calcitonin gene-related peptide (CGRP) levels during glyceryl trinitrate (GTN)-induced headache in healthy volunteers'.
Topics: Calcitonin Gene-Related Peptide; Headache; Humans; Nitric Oxide Donors; Nitroglycerin; Vasodilation | 2011 |
Headache in three new cases of Harlequin syndrome with accompanying pharmacological comparison with migraine.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Diagnosis, Differential; Dihydroergotamine; Ergotami | 2012 |
[Headache due to nitroglycerin administration and its clinical significance].
Topics: Administration, Sublingual; Adult; Age Factors; Aged; Alcohol Drinking; Coronary Angiography; Corona | 2002 |
[Horton's disease presenting as a myocardial infarction].
Topics: Adrenergic beta-Antagonists; Anti-Inflammatory Agents; Anticoagulants; Biopsy; Coronary Angiography; | 1999 |
Comparison of the vasodilating effect of nitroglycerin, verapamil, and tolazoline in hand angiography.
Topics: Adult; Aged; Angiography; Contrast Media; Erythema; Female; Hand; Headache; Hot Temperature; Humans; | 2003 |
[Disposition to headache].
Topics: Headache; Histamine; Humans; Nitroglycerin; Personality | 1951 |
Electro-encephalographic investigations after administration of nitroglycerine, histamine and ergotamine preparations.
Topics: Electroencephalography; Ergotamine; Headache; Histamine; Humans; Nitroglycerin | 1951 |
Nitroglycerin induces migraine headache and central sensitization phenomena in patients with migraine without aura: a study of laser evoked potentials.
Topics: Adult; Carbon Dioxide; Evoked Potentials; Female; Functional Laterality; Hand; Headache; Humans; Las | 2004 |
Headache response to glyceryl trinitrate in patients with and without obstructive coronary artery disease.
Topics: Aged; Chest Pain; Coronary Angiography; Coronary Stenosis; Female; Headache; Humans; Male; Middle Ag | 2005 |
[Nitroglycerin-induced headaches].
Topics: Administration, Sublingual; Adult; Calcitonin Gene-Related Peptide; Case-Control Studies; Female; He | 2004 |
Images in cardiovascular medicine. Hypertensive brainstem encephalopathy.
Topics: Abdominal Pain; Adult; Blood-Brain Barrier; Brain Edema; Brain Stem; Drugs, Chinese Herbal; Headache | 2007 |
Effects of autogenic training on nitroglycerin-induced headaches.
Topics: Administration, Sublingual; Adult; Autogenic Training; Female; Headache; Humans; Middle Aged; Nitrog | 2007 |
GTN headaches and reduction of natural banding?
Topics: Administration, Topical; Dose-Response Relationship, Drug; Fissure in Ano; Follow-Up Studies; Headac | 2008 |
[Drug-induced headache].
Topics: Anti-Arrhythmia Agents; Calcium; Headache; Histamine Release; Humans; Kinins; Nitroglycerin; Prostag | 1983 |
Benign paroxysmal vertigo in childhood. Diagnostic significance of vestibular examination and headache provocation tests.
Topics: Child; Child, Preschool; Female; Fenfluramine; Headache; Histamine; Humans; Male; Nitroglycerin; Ver | 1984 |
Glyceryltrinitrate as a problem in industry.
Topics: Air Pollutants, Occupational; Blood Pressure; Female; Headache; Heart Rate; Humans; Male; Maximum Al | 1984 |
[Drug therapy of coronary disease. Nitrates in acute and longtime therapy].
Topics: Coronary Disease; Headache; Humans; Isosorbide Dinitrate; Nitrates; Nitroglycerin; Time Factors | 1980 |
[Nosologic definition, pathogenesis and diagnosis of headache].
Topics: Adolescent; Adult; Cluster Headache; Fundus Oculi; Headache; Histamine; Humans; Nitroglycerin; Prola | 1982 |
Experimental headache in humans.
Topics: Cerebrovascular Circulation; Dose-Response Relationship, Drug; Headache; Hemodynamics; Humans; Model | 1995 |
Treatment of benign anal disease with topical nitroglycerin.
Topics: Administration, Topical; Adult; Anal Canal; Defecation; Female; Fissure in Ano; Follow-Up Studies; H | 1995 |
Cervicogenic headache: responses to nitroglycerin, oxygen, ergotamine and morphine.
Topics: Ergotamine; Female; Headache; Humans; Male; Morphine; Neck; Nitroglycerin; Oxygen | 1993 |
Middle cerebral artery velocity correlates with nitroglycerin-induced headache onset.
Topics: Administration, Cutaneous; Adult; Blood Flow Velocity; Blood Pressure; Carbon Dioxide; Cerebral Arte | 1996 |
Therapy of angina pectoris with long-acting nitrates: which agent and when?
Topics: Angina Pectoris; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Tolerance; Head | 1996 |
Nitroglycerin-induced headache.
Topics: Arteriovenous Anastomosis; Dose-Response Relationship, Drug; Head; Headache; Humans; Migraine Disord | 1996 |
Glyceryl trinitrate ointment for chronic anal fissure.
Topics: Chronic Disease; Fissure in Ano; Headache; Humans; Nitroglycerin; Ointments | 1997 |
Clinical application of the nitroglycerin lingual spray.
Topics: Administration, Sublingual; Angina Pectoris; Blood Flow Velocity; Blood Pressure; Diastole; Echocard | 1998 |
Headaches in the treatment of anal fissure.
Topics: Administration, Topical; Fecal Incontinence; Fissure in Ano; Headache; Humans; Nitroglycerin; Vasodi | 1999 |
Activation of trigeminovascular neurons by glyceryl trinitrate.
Topics: Animals; Blood Pressure; Carotid Artery, Common; Cats; Dura Mater; Electric Stimulation; Female; Hea | 2000 |
Calcitonin gene-related peptide levels during nitric oxide-induced headache in patients with chronic tension-type headache.
Topics: Adult; Calcitonin Gene-Related Peptide; Chronic Disease; Female; Headache; Humans; Male; Middle Aged | 2001 |
[Nitrate headache in blasting work].
Topics: Diagnosis, Differential; Explosions; Headache; Humans; Male; Middle Aged; Nitroglycerin; Occupationa | 2001 |
History of headache research in Denmark.
Topics: Denmark; Headache; History, 20th Century; Humans; Nitroglycerin; Research; Tension-Type Headache; Va | 2001 |
Systemic levels of glyceryl trinitrate following topical application to the anoderm do not correlate with the measured reduction in anal pressure.
Topics: Absorption; Administration, Topical; Adult; Aged; Anal Canal; Blood Pressure; Female; Headache; Huma | 2001 |
Glyceryl trinitrate treatment up-regulates soluble guanylyl cyclase in rat dura mater.
Topics: Animals; Dura Mater; Endothelium, Vascular; Female; Guanylate Cyclase; Headache; Male; Microscopy, I | 2001 |
Re: glyceryl trinitrate (GTN) patches are unsuitable in hypertensive pregnancy.
Topics: Administration, Cutaneous; Female; Headache; Humans; Nitroglycerin; Pre-Eclampsia; Pregnancy; Random | 2001 |
[Headaches in the evolutive age: nosographic classification by means of the evaluative rating scale and diagnostic tests].
Topics: Age Factors; Bromocriptine; Child; Child, Preschool; Female; Headache; Histamine; Humans; Male; Medi | 1979 |
[Experience with adalat, a coronary therapeutic agent in medical practice (authors transl)].
Topics: Angina Pectoris; Blood Pressure; Drug Evaluation; Female; Headache; Humans; Male; Middle Aged; Nifed | 1977 |
[Role of the vascular component in the pathogenesis of headaches in neurotic patients].
Topics: Cold Temperature; Head; Headache; Humans; Nitroglycerin; Plethysmography, Impedance; Stress, Physiol | 1977 |
Nitroglycerin for angina pectoris.
Topics: Angina Pectoris; Drug Stability; Headache; Humans; Nitroglycerin | 1978 |
[Cluster headache].
Topics: Age Factors; Ethanol; Headache; Humans; Nitroglycerin; Rest; Seasons; Sex Factors; Syndrome; Time Fa | 1975 |
Behavioural changes in rats suggesting drug-induced headache [proceedings].
Topics: Animals; Avoidance Learning; Behavior, Animal; Disease Models, Animal; Drug Tolerance; Headache; Nit | 1976 |
Cerebrospinal fluid pressure and venous pressure in "dynamite headache" and cluster headache attacks.
Topics: Adult; Aged; Cerebral Veins; Cerebrospinal Fluid Pressure; Cluster Headache; Female; Frontal Lobe; H | 1992 |
Non-invasive management of impotence with transcutaneous nitroglycerin.
Topics: Administration, Cutaneous; Aged; Erectile Dysfunction; Headache; Humans; Male; Middle Aged; Nitrogly | 1992 |
The safety of intravenous dipyridamole thallium myocardial perfusion imaging. Intravenous Dipyridamole Thallium Imaging Study Group.
Topics: Adult; Aged; Aminophylline; Bronchial Spasm; Chest Pain; Dipyridamole; Female; Headache; Heart; Hemo | 1990 |
Headache angina with fatal outcome.
Topics: Aged; Angina Pectoris; Electrocardiography, Ambulatory; Female; Headache; Humans; Male; Middle Aged; | 1990 |
[Clinical study of a new nitroglycerin spray preparation in patients with exertion stable angina].
Topics: Administration, Inhalation; Adult; Aged; Angina Pectoris; Female; Headache; Humans; Male; Middle Age | 1986 |
Unmasking latent dysnociception in healthy subjects.
Topics: Adolescent; Adult; Female; Headache; Humans; Male; Migraine Disorders; Nitroglycerin | 1987 |
Exposure to glyceryl trinitrate during gun powder production: plasma glyceryl trinitrate concentration, elimination kinetics, and discomfort among production workers.
Topics: Adult; Air; Blood Pressure; Chemical Industry; Environmental Exposure; Female; Headache; Humans; Kin | 1985 |
Clinical aspects of cluster headache.
Topics: Adolescent; Adult; Age Factors; Aged; Blood Pressure; Electrocardiography; Female; Headache; Heart R | 1974 |
Physiologic and clinical actions of nitroglycerin.
Topics: Angina Pectoris; Animals; Animals, Laboratory; Coronary Circulation; Headache; Hemodynamics; Humans; | 1974 |
Instability of nitroglycerin tablets.
Topics: Angina Pectoris; Drug Stability; Headache; Humans; Middle Aged; Nitroglycerin; Refrigeration; Tablet | 1974 |
[The effects of nitrite compounds in angina pectoris (author's transl)].
Topics: Angina Pectoris; Headache; Humans; Nitrites; Nitroglycerin; Oxygen Consumption; Vertigo | 1974 |
Headaches in explosive magazine workers.
Topics: Air Pollution; Australia; Blood Pressure; Glycols; Headache; Humans; Male; Nitrates; Nitroglycerin; | 1966 |
Withdrawal symptoms in workers exposed to nitroglycerine.
Topics: Adult; Angina Pectoris; Chemical Industry; Death, Sudden; Diagnosis, Differential; Environmental Exp | 1968 |
[The effect of nitroglycerin on the tone of the cerebral vessels and the pathogenesis of "nitroglycerin" headaches].
Topics: Adult; Blood Pressure; Cerebrovascular Circulation; Female; Headache; Humans; Male; Middle Aged; Nit | 1967 |
Nitrolglycerin as a provocative agent in cluster headache.
Topics: Adult; Blood Pressure; Headache; Humans; Male; Middle Aged; Nitroglycerin; Pain; Parasympatholytics; | 1968 |
[Urinary excretion of catecholamines and vanilmandelic acid during headache attacks induced with trinitroglycerin].
Topics: Adult; Catecholamines; Female; Headache; Humans; Male; Mandelic Acids; Nitroglycerin; Vanilmandelic | 1967 |
[Urinary excretion of 5-hydroxyindoleacetic acid during headache attacks induced with trinitroglycerin].
Topics: Adult; Female; Headache; Humans; Hydroxyindoleacetic Acid; Male; Nitroglycerin | 1967 |
Heart rate, blood pressure, and electrocardiographic changes during provoked attacks of cluster headache.
Topics: Adult; Blood Pressure; Electrocardiography; Headache; Heart Rate; Humans; Male; Middle Aged; Nitrogl | 1970 |
A clinical comparison of cluster headache and migraine.
Topics: Adolescent; Adult; Aged; Carotid Arteries; Chronic Disease; Diagnosis, Differential; Ergotamine; Fem | 1970 |
[Study of "medical headaches". 4. Discussion of the relative incidence found with the nitrite induction test].
Topics: Headache; Humans; Italy; Migraine Disorders; Nitrites; Nitroglycerin | 1968 |
Effect of induced rise of blood pressure on pain in cluster headache.
Topics: Adult; Age Factors; Blood Pressure; Headache; Heart Rate; Histamine; Humans; Injections, Intravenous | 1970 |