nitroglycerin has been researched along with Endotoxin Shock in 11 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the context of a strict resuscitation protocol, based upon fulfillment of systemic hemodynamic end points in patients with early-phase severe sepsis or septic shock, we conclude that intravenous nitroglycerin does not promote sublingual microcirculatory blood flow." | 9.14 | Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial. ( Bakker, AJ; Boerma, EC; Bruins, N; Buter, H; Egbers, PH; Gerritsen, RT; Ince, C; Kaiferova, K; Kingma, WP; Koetsier, PM; Konijn, A; Koopmans, M; Kuiper, MA; van Roon, EN, 2010) |
| "In the context of a strict resuscitation protocol, based upon fulfillment of systemic hemodynamic end points in patients with early-phase severe sepsis or septic shock, we conclude that intravenous nitroglycerin does not promote sublingual microcirculatory blood flow." | 5.14 | Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial. ( Bakker, AJ; Boerma, EC; Bruins, N; Buter, H; Egbers, PH; Gerritsen, RT; Ince, C; Kaiferova, K; Kingma, WP; Koetsier, PM; Konijn, A; Koopmans, M; Kuiper, MA; van Roon, EN, 2010) |
| "In patients with septic shock, oxygen consumption is increased, but oxygen delivery and extraction is impaired, partly because of microcirculatory shutdown and shunting." | 2.70 | Nitroglycerin in septic shock after intravascular volume resuscitation. ( Gardien, MJ; Ince, C; Mathura, KR; Oudemans-van Straaten, HM; Spronk, PE; Zandstra, DF, 2002) |
| "Nitroglycerin was infused at a rate of 0." | 1.37 | Failure of nitroglycerin (glyceryl trinitrate) to improve villi hypoperfusion in endotoxaemic shock in sheep. ( Canales, HS; Canullén, C; Dubin, A; Edul, VS; Estenssoro, E; Ferrara, G; Ince, C; Martins, E; Murias, G; Pozo, MO, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Felice, VB | 1 |
| de Moraes, RB | 1 |
| Bakker, J | 1 |
| Friedman, G | 1 |
| Boerma, EC | 1 |
| Koopmans, M | 1 |
| Konijn, A | 1 |
| Kaiferova, K | 1 |
| Bakker, AJ | 1 |
| van Roon, EN | 1 |
| Buter, H | 1 |
| Bruins, N | 1 |
| Egbers, PH | 1 |
| Gerritsen, RT | 1 |
| Koetsier, PM | 1 |
| Kingma, WP | 1 |
| Kuiper, MA | 1 |
| Ince, C | 3 |
| Favory, R | 1 |
| Salgado, D | 1 |
| Vincent, JL | 2 |
| De Backer, D | 2 |
| García Soler, P | 1 |
| Milano Manso, G | 1 |
| Camacho Alonso, JM | 1 |
| Manuel González, J | 1 |
| Edul, VS | 1 |
| Ferrara, G | 1 |
| Pozo, MO | 1 |
| Murias, G | 1 |
| Martins, E | 1 |
| Canullén, C | 1 |
| Canales, HS | 1 |
| Estenssoro, E | 1 |
| Dubin, A | 1 |
| Spronk, PE | 1 |
| Gardien, MJ | 1 |
| Mathura, KR | 1 |
| Oudemans-van Straaten, HM | 1 |
| Zandstra, DF | 1 |
| Preiser, JC | 1 |
| White, JD | 1 |
| Arden, WA | 1 |
| Fiscus, RR | 1 |
| Wang, X | 1 |
| Maley, R | 1 |
| Lanzo, S | 1 |
| Gross, DR | 1 |
| Sheu, JR | 1 |
| Hsiao, G | 1 |
| Lee, C | 1 |
| Chang, W | 1 |
| Lee, LW | 1 |
| Su, CH | 1 |
| Lin, CH | 1 |
| Cerra, FB | 1 |
| Hassett, J | 1 |
| Siegel, JH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Evaluation of the Effect of Nitroglycerine Versus Placebo on the Microcirculation by Means of SDF Imaging in Septic Patients on the ICU[NCT00493415] | Phase 3 | 70 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| Early Lactate-Directed Therapy on the ICU: A Randomized Controlled Trial[NCT00270673] | Phase 3 | 350 participants (Anticipated) | Interventional | 2006-02-28 | Completed | ||
| The Prognostic Value of Simultaneous Assessment of Microcirculation Alteration With Sublingual Microcirculation and Near-infrared Spectroscopy on the Acute Respiratory Distress Syndrome of Various Phenotypes[NCT05180409] | 60 participants (Anticipated) | Observational | 2020-12-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for nitroglycerin and Endotoxin Shock
| Article | Year |
|---|---|
Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial.
Topics: Administration, Sublingual; Adult; Aged; Blood Flow Velocity; Cause of Death; Critical Care; Dose-Re | 2010 |
Nitroglycerin in septic shock after intravascular volume resuscitation.
Topics: Adult; Aged; APACHE; Cardiopulmonary Resuscitation; Humans; Microcirculation; Middle Aged; Nitroglyc | 2002 |
Nitroglycerin in septic shock after intravascular volume resuscitation.
Topics: Adult; Aged; APACHE; Cardiopulmonary Resuscitation; Humans; Microcirculation; Middle Aged; Nitroglyc | 2002 |
Nitroglycerin in septic shock after intravascular volume resuscitation.
Topics: Adult; Aged; APACHE; Cardiopulmonary Resuscitation; Humans; Microcirculation; Middle Aged; Nitroglyc | 2002 |
Nitroglycerin in septic shock after intravascular volume resuscitation.
Topics: Adult; Aged; APACHE; Cardiopulmonary Resuscitation; Humans; Microcirculation; Middle Aged; Nitroglyc | 2002 |
9 other studies available for nitroglycerin and Endotoxin Shock
| Article | Year |
|---|---|
Nitroglycerin infusion improves peripheral perfusion of patients with septic shock.
Topics: Hemodynamics; Humans; Microcirculation; Nitroglycerin; Perfusion; Resuscitation; Shock, Septic | 2023 |
Can normal be more normal than normal?
Topics: Administration, Sublingual; Data Interpretation, Statistical; Humans; Microcirculation; Nitroglyceri | 2010 |
[Iloprost for the treatment of digital ischaemia in pediatric septic shock].
Topics: Angiogenesis Inducing Agents; Child, Preschool; Combined Modality Therapy; Cross Infection; Debridem | 2011 |
Failure of nitroglycerin (glyceryl trinitrate) to improve villi hypoperfusion in endotoxaemic shock in sheep.
Topics: Animals; Blood Flow Velocity; Hemodynamics; Lactic Acid; Microcirculation; Nitric Oxide; Nitroglycer | 2011 |
Nitroglycerin for septic shock.
Topics: Humans; Hypotension; Nitroglycerin; Shock, Septic; Vasodilator Agents | 2003 |
Nitroprusside or nitroglycerin.
Topics: Ferricyanides; Humans; Nitroglycerin; Nitroprusside; Shock, Septic | 1981 |
Early endotoxic shock results in enhanced vasodilator responses to nitroglycerin but unaltered responses to neuropeptides calcitonin gene-related peptide and substance P.
Topics: Animals; Arteries; Calcitonin Gene-Related Peptide; Escherichia coli; In Vitro Techniques; Lipopolys | 1994 |
Antiplatelet activity of Staphylococcus aureus lipoteichoic acid is mediated through a cyclic AMP pathway.
Topics: Alprostadil; Blood Platelets; Blood Proteins; Calcium Signaling; Collagen; Cyclic AMP; Cyclic GMP; C | 2000 |
Vasodilator therapy in clinical sepsis with low output syndrome.
Topics: Aged; Cardiac Output; Humans; Middle Aged; Nitroglycerin; Shock, Cardiogenic; Shock, Septic; Syndrom | 1978 |