Page last updated: 2024-11-01

nitroglycerin and Endotoxemia

nitroglycerin has been researched along with Endotoxemia in 6 studies

Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.

Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.

Research Excerpts

ExcerptRelevanceReference
"In a randomized, placebo-controlled, parallel group study, forearm blood flow (FBF) responses to NE, ACh, and the endothelium-independent vasodilator nitroglycerin (NTG) were assessed at baseline, after 4 days of simvastatin 80 mg PO or placebo treatment, and during Escherichia coli endotoxin (lipopolysaccharide [LPS])-induced inflammation in 20 healthy volunteers."9.11Simvastatin prevents vascular hyporeactivity during inflammation. ( Kapiotis, S; Marsik, C; Mittermayer, F; Pleiner, J; Polterauer, S; Schaller, G; Wolzt, M; Zorn, S, 2004)
"In a randomized, placebo-controlled, parallel group study, forearm blood flow (FBF) responses to NE, ACh, and the endothelium-independent vasodilator nitroglycerin (NTG) were assessed at baseline, after 4 days of simvastatin 80 mg PO or placebo treatment, and during Escherichia coli endotoxin (lipopolysaccharide [LPS])-induced inflammation in 20 healthy volunteers."5.11Simvastatin prevents vascular hyporeactivity during inflammation. ( Kapiotis, S; Marsik, C; Mittermayer, F; Pleiner, J; Polterauer, S; Schaller, G; Wolzt, M; Zorn, S, 2004)
"1."1.35Effects of 1400W and/or nitroglycerin on renal oxygenation and kidney function during endotoxaemia in anaesthetized rats. ( Dieterich, HJ; Goedhart, PT; Ince, C; Johannes, T; Klingel, K; Mik, EG; Nohé, B; Unertl, KE; Zanke, C, 2009)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's4 (66.67)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cox, LA1
van Eijk, LT1
Ramakers, BP1
Dorresteijn, MJ1
Gerretsen, J1
Kox, M1
Pickkers, P1
Johannes, T1
Mik, EG1
Klingel, K1
Goedhart, PT1
Zanke, C1
Nohé, B1
Dieterich, HJ1
Unertl, KE1
Ince, C1
Evans, RG1
May, CN1
Pleiner, J1
Schaller, G1
Mittermayer, F1
Zorn, S1
Marsik, C1
Polterauer, S1
Kapiotis, S1
Wolzt, M1
Kozlov, AV1
Albrecht, M1
Donnelly, EM1
Jafarmadar, M1
Szelenyi, Z1
Nohl, H1
Redl, H1
Bahrami, S1
Inan, M1
Sayek, I1
Tel, BC1
Sahin-Erdemli, I1

Trials

2 trials available for nitroglycerin and Endotoxemia

ArticleYear
Inflammation-induced increases in plasma endocan levels are associated with endothelial dysfunction in humans in vivo.
    Shock (Augusta, Ga.), 2015, Volume: 43, Issue:4

    Topics: Adult; Blood Flow Velocity; Endothelium, Vascular; Endotoxemia; Forearm; Healthy Volunteers; Humans;

2015
Simvastatin prevents vascular hyporeactivity during inflammation.
    Circulation, 2004, Nov-23, Volume: 110, Issue:21

    Topics: Acetylcholine; Adult; Double-Blind Method; Endotoxemia; Endotoxins; Forearm; Humans; Inflammation; M

2004

Other Studies

4 other studies available for nitroglycerin and Endotoxemia

ArticleYear
Effects of 1400W and/or nitroglycerin on renal oxygenation and kidney function during endotoxaemia in anaesthetized rats.
    Clinical and experimental pharmacology & physiology, 2009, Volume: 36, Issue:9

    Topics: Acute Kidney Injury; Amidines; Anesthesia, General; Animals; Benzylamines; Biomarkers; Creatinine; D

2009
Tissue hypoxia as a therapeutic target in acute kidney injury.
    Clinical and experimental pharmacology & physiology, 2009, Volume: 36, Issue:9

    Topics: Acute Kidney Injury; Amidines; Animals; Benzylamines; Endotoxemia; Enzyme Inhibitors; Kidney; Male;

2009
Release and hemodynamic influence of nitro-glycerine-derived nitric oxide in endotoxemic rats.
    Vascular pharmacology, 2005, Volume: 43, Issue:6

    Topics: Animals; Blood Pressure; Chelating Agents; Ditiocarb; Electron Spin Resonance Spectroscopy; Endotoxe

2005
Role of endotoxin and nitric oxide in the pathogenesis of renal failure in obstructive jaundice.
    The British journal of surgery, 1997, Volume: 84, Issue:7

    Topics: Acetylcholine; Acute Kidney Injury; Animals; Bile Ducts; Bilirubin; Blood Pressure; Cholestasis; Col

1997