nitroglycerin has been researched along with Emergencies in 69 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Emergencies: Situations or conditions requiring immediate intervention to avoid serious adverse results.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypertensive emergencies are potentially life threatening and require prompt blood pressure control with intravenous agents." | 5.48 | Sublingual nitroglycerin for early blood pressure control in hypertensive emergencies: observations from an emergency department clinical audit in Sri Lanka. ( Constantine, GR; Dissanayake, HA; Prasanna, N, 2018) |
| " Hydralazine has been widely used in treatment of hypertension in eclampsia and preeclampsia, and its safety has been demonstrated in these patients." | 4.79 | Management of hypertensive urgencies and emergencies. ( Abdelwahab, W; Frishman, W; Landau, A, 1995) |
| " Nitroglycerin was named as first choice only for pulmonary oedema or myocardial infarction." | 3.70 | [Diagnostic and therapeutic procedures by doctors for patients in a hypertensive crisis. An inquiry in 56 internal medicine clinics]. ( Grieshaber, M; Schwietzer, G; Stahl, RA; Wenzel, UO, 1998) |
| "Three hundred prehospital patients who were given nitroglycerin by advanced life support personnel for presumed myocardial ischemia or congestive heart failure; excluded were those without repeat vital signs or ECG monitoring and those given additional medications." | 3.69 | Safety of prehospital nitroglycerin. ( Holliman, CJ; Meador, S; Roth, GS; Swope, G; Wuerz, R, 1994) |
| "In the case of hypertensive encephalopathy, the lowering of blood pressure is therapeutic as well as diagnostic." | 2.43 | [Antihypertensive management in acute cerebral stroke]. ( Ziliene, V, 2005) |
| "The role of colloids in the treatment of pulmonary edema is controversial." | 2.37 | Acute pulmonary edema. ( Guntupalli, KK, 1984) |
| "Whether the pulmonary edema is cardiogenic or noncardiogenic, optimal management is facilitated by the improvement of ventilation and gas exchange within the lungs and the restoration of oxygen transport to peripheral tissues." | 2.36 | Acute alveolar edema. ( Nowakowski, JF, 1983) |
| "Hypertensive emergencies are potentially life threatening and require prompt blood pressure control with intravenous agents." | 1.48 | Sublingual nitroglycerin for early blood pressure control in hypertensive emergencies: observations from an emergency department clinical audit in Sri Lanka. ( Constantine, GR; Dissanayake, HA; Prasanna, N, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (20.29) | 18.7374 |
| 1990's | 33 (47.83) | 18.2507 |
| 2000's | 17 (24.64) | 29.6817 |
| 2010's | 5 (7.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prasanna, N | 1 |
| Dissanayake, HA | 1 |
| Constantine, GR | 1 |
| Pieren, JA | 2 |
| Gadbury-Amyot, CC | 1 |
| Kandray, DP | 2 |
| Van Ness, CJ | 1 |
| Mitchell, TV | 1 |
| Legler, A | 1 |
| Kim, RK | 1 |
| Chawla, N | 1 |
| Wittig, T | 1 |
| Kuhlmann, U | 1 |
| Hoyer, J | 1 |
| Holzgreve, H | 2 |
| Odunukan, OW | 1 |
| Abudiab, MM | 1 |
| Sinak, LJ | 1 |
| López de la Iglesia, J | 1 |
| Martínez Ramos, E | 1 |
| Pardo Franco, L | 1 |
| Escudero Alvarez, S | 1 |
| Cañón de la Parra, RI | 1 |
| Costas Mira, MT | 1 |
| Stiefelhagen, P | 1 |
| DeBusk, RF | 1 |
| Jeron, A | 1 |
| Murdoch, JA | 1 |
| Lane, J | 1 |
| Goldstein, DH | 1 |
| Ziliene, V | 1 |
| Grogan, DM | 1 |
| Haas, DA | 1 |
| Benner, RW | 1 |
| Majdalany, D | 1 |
| Prabhu, S | 1 |
| Makaryus, AN | 1 |
| Hollman, J | 1 |
| Gruentzig, AR | 1 |
| Douglas, JS | 1 |
| King, SB | 1 |
| Ischinger, T | 1 |
| Meier, B | 1 |
| Cribier, A | 1 |
| Berland, J | 1 |
| Richard, C | 1 |
| Redonnet, M | 1 |
| Champoud, O | 1 |
| Behar, P | 1 |
| Saoudi, N | 1 |
| Letac, B | 1 |
| You, K | 1 |
| Nowakowski, JF | 1 |
| Guntupalli, KK | 1 |
| Goldberg, GJ | 1 |
| Wasserberger, K | 1 |
| Balasubramaniam, S | 1 |
| Nakata, A | 1 |
| Nakabayashi, T | 1 |
| Iuchi, K | 1 |
| Ishikawa, T | 1 |
| Wessén, A | 1 |
| Elowsson, P | 1 |
| Axemo, P | 1 |
| Lindberg, B | 1 |
| Utoh, J | 1 |
| Miyauchi, Y | 1 |
| Goto, H | 1 |
| Obayashi, H | 1 |
| Hirata, T | 1 |
| Nashed, AH | 2 |
| Allegra, JR | 2 |
| Jeske, AH | 2 |
| Redden, RE | 2 |
| McCarthy, FM | 1 |
| Andrivet, P | 1 |
| Larsen, S | 1 |
| Horowitz, M | 1 |
| MacAfee, KA | 1 |
| Chisdak, B | 1 |
| Hersh, EV | 1 |
| Wuerz, R | 1 |
| Swope, G | 1 |
| Meador, S | 1 |
| Holliman, CJ | 1 |
| Roth, GS | 1 |
| Silvain, C | 2 |
| Carpentier, S | 1 |
| Sautereau, D | 2 |
| Czernichow, B | 1 |
| Métreau, JM | 1 |
| Fort, E | 2 |
| Ingrand, P | 2 |
| Boyer, J | 1 |
| Pillegand, B | 2 |
| Doffël, M | 1 |
| Stepin, J | 1 |
| Abdelwahab, W | 1 |
| Frishman, W | 1 |
| Landau, A | 1 |
| Nagy, V | 1 |
| Zámolyi, K | 1 |
| Szegedi, N | 2 |
| Székács, B | 1 |
| Dufour, P | 3 |
| Vinatier, D | 3 |
| Vanderstichele, S | 1 |
| Ducloy, JC | 1 |
| Monnier, JC | 2 |
| Puech, F | 2 |
| Sanyal, AJ | 1 |
| Freedman, AM | 1 |
| Luketic, VA | 1 |
| Purdum, PP | 1 |
| Shiffman, ML | 1 |
| Tisnado, J | 1 |
| Cole, PE | 1 |
| Altmann, DB | 1 |
| Racz, M | 1 |
| Battleman, DS | 1 |
| Bergman, G | 1 |
| Spokojny, A | 1 |
| Hannan, EL | 1 |
| Sanborn, TA | 1 |
| Bouthors, AS | 1 |
| Orazi, G | 2 |
| Subtil, D | 1 |
| Ducloy, AS | 1 |
| Borowski, A | 1 |
| Korb, H | 1 |
| Malamed, SF | 1 |
| Gouveia, D | 1 |
| Escudero, J | 1 |
| Domingo, E | 1 |
| Anivarro, I | 1 |
| Angel, J | 1 |
| Soler, JS | 1 |
| Wenzel, UO | 1 |
| Stahl, RA | 1 |
| Grieshaber, M | 1 |
| Schwietzer, G | 1 |
| Atherton, GJ | 1 |
| McCaul, JA | 1 |
| Williams, SA | 1 |
| Werdan, K | 1 |
| Schwinger, RH | 1 |
| Littrell, KA | 1 |
| Kern, KB | 1 |
| Bussmann, WD | 1 |
| Schupp, D | 1 |
| Matloff, DS | 1 |
| Sefrin, P | 1 |
| Schwarzmann, G | 1 |
| Surpure, JS | 1 |
| Hancock, EW | 1 |
| Ghio, S | 1 |
| Angoli, L | 1 |
| Bramucci, E | 1 |
| de Servi, S | 1 |
| Specchia, G | 1 |
| Beauchant, M | 1 |
| Treasure, T | 1 |
| Carreras, F | 1 |
| García, J | 1 |
| Augé, JM | 1 |
| Crexells, C | 1 |
| Oriol, A | 1 |
| Ferguson, RK | 1 |
| Vlasses, PH | 1 |
| Vidt, DG | 1 |
| Tebbe, U | 1 |
| Sauer, G | 1 |
| Kreuzer, H | 1 |
| Vogt, A | 1 |
| Bethge, KP | 1 |
| Wiegand, V | 1 |
| Neuhaus, KL | 1 |
| Hoffman, JR | 1 |
| Reynolds, S | 1 |
| De Cotiis, R | 1 |
| Lombardi, C | 1 |
| Spedini, C | 1 |
15 reviews available for nitroglycerin and Emergencies
| Article | Year |
|---|---|
[Hypertensive emergency].
Topics: Antihypertensive Agents; Aortic Aneurysm; Aortic Dissection; Emergencies; Humans; Hypertension; Nitr | 2008 |
[Antihypertensive management in acute cerebral stroke].
Topics: Acute Disease; Adult; Antihypertensive Agents; Brain Injuries; Cerebrovascular Circulation; Emergenc | 2005 |
Acute alveolar edema.
Topics: Acute Disease; Adrenal Cortex Hormones; Altitude Sickness; Aminophylline; Anti-Arrhythmia Agents; Ca | 1983 |
Acute pulmonary edema.
Topics: Adrenal Cortex Hormones; Bloodletting; Capillary Permeability; Digoxin; Diuretics; Dobutamine; Dopam | 1984 |
A minimum medical emergency kit.
Topics: Dental Offices; Emergencies; Emergency Medical Services; Epinephrine; Equipment and Supplies; Humans | 1994 |
Angina pectoris-diagnosis and treatment in the outpatient setting.
Topics: Angina Pectoris; Dental Care for Chronically Ill; Emergencies; Humans; Nitroglycerin | 1993 |
Management of hypertensive urgencies and emergencies.
Topics: Administration, Oral; Antihypertensive Agents; Emergencies; Enalaprilat; Female; Humans; Hydralazine | 1995 |
[Emergency situations in hypertension].
Topics: Administration, Sublingual; Antihypertensive Agents; Captopril; Crisis Intervention; Emergencies; Fe | 1996 |
[De-novo reversible stenoses in tortuous arteries during coronary angioplasty due to the accordion effect. A clinical case and review of the literature].
Topics: Angioplasty, Balloon, Coronary; Cardiac Catheterization; Coronary Angiography; Coronary Disease; Eme | 1997 |
[Emergency treatment of acute heart failure].
Topics: Acute Disease; Adrenergic beta-Antagonists; Aged; Analgesics, Opioid; Angioplasty, Balloon, Coronary | 1999 |
Acute ischemic syndromes. Adjunctive therapy.
Topics: Acute Disease; Angina, Unstable; Angiotensin-Converting Enzyme Inhibitors; Cardiotonic Agents; Chest | 2002 |
Treatment of acute variceal bleeding.
Topics: Acute Disease; Balloon Occlusion; Catheterization; Drug Administration Schedule; Emergencies; Endosc | 1992 |
[Emergency drugs in respiratory disorders. A choice of commonly used substances].
Topics: Adrenergic beta-Agonists; Airway Obstruction; Catecholamines; Emergencies; Furosemide; Glucocorticoi | 1991 |
Hypertensive emergencies and urgencies.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; | 1986 |
[Hypertensive emergencies and urgencies: current therapeutic approach].
Topics: Antihypertensive Agents; Dihydroergotoxine; Emergencies; Hypertension; Nitroglycerin; Trimethaphan | 1987 |
5 trials available for nitroglycerin and Emergencies
| Article | Year |
|---|---|
Hemodynamic effects of bolus nicorandil compared with nitroglycerin.
Topics: Aged; Cardiovascular Diseases; Emergencies; Female; Hemodynamics; Humans; Male; Middle Aged; Niacina | 1995 |
Terlipressin plus transdermal nitroglycerin vs. octreotide in the control of acute bleeding from esophageal varices: a multicenter randomized trial.
Topics: Administration, Cutaneous; Adult; Aged; Blood Pressure; Drug Therapy, Combination; Emergencies; Esop | 1993 |
Transjugular intrahepatic portosystemic shunts for patients with active variceal hemorrhage unresponsive to sclerotherapy.
Topics: Adult; Aged; Balloon Occlusion; Catheterization; Combined Modality Therapy; Emergencies; Esophageal | 1996 |
Myocardial protection by pressure- and volume-controlled continuous hypothermic coronary perfusion (PVC-CONTHY-CAP) in combination with ultra-short beta-blockade and nitroglycerine.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Cardiopulmonary Bypass; Chi | 1997 |
A randomized trial of terlipressin plus nitroglycerin vs. balloon tamponade in the control of acute variceal hemorrhage.
Topics: Adult; Aged; Balloon Occlusion; Catheterization; Drug Therapy, Combination; Emergencies; Esophageal | 1990 |
49 other studies available for nitroglycerin and Emergencies
| Article | Year |
|---|---|
Sublingual nitroglycerin for early blood pressure control in hypertensive emergencies: observations from an emergency department clinical audit in Sri Lanka.
Topics: Administration, Sublingual; Aged; Blood Pressure; Blood Pressure Determination; Clinical Audit; Emer | 2018 |
The attitudes of Ohio dentists and dental hygienists regarding the use of automated external defibrillators in the dental setting--a follow-up study.
Topics: Attitude of Health Personnel; Cardiopulmonary Resuscitation; Death, Sudden, Cardiac; Defibrillators; | 2013 |
Glucagon-induced hypertensive emergency: a case report.
Topics: Antihypertensive Agents; Emergencies; Female; Gastrointestinal Agents; Glucagon; Humans; Hydralazine | 2016 |
[Hypertensive crisis: collapse after using nitro spray. For the elderly a low dose chew capsule is better!].
Topics: Administration, Sublingual; Aerosols; Dose-Response Relationship, Drug; Emergencies; Epistaxis; Fema | 2008 |
Best evidence topic reports. Bet 1. Managing acute pulmonary oedema: high or standard dose glyceryl trinitrate?
Topics: Acute Disease; Aged; Dose-Response Relationship, Drug; Emergencies; Evidence-Based Emergency Medicin | 2009 |
[Hypertensive urgency or hypertensive emergency?].
Topics: Adult; Antihypertensive Agents; Blood Pressure Determination; Emergencies; Female; Follow-Up Studies | 2010 |
48-year-old man with cough and leg swelling.
Topics: Acute Disease; Antihypertensive Agents; Cerebrovascular Circulation; Cough; Dyspnea; Echocardiograph | 2012 |
[Questionnaire for patients with ischaemic cardiopathy on their reaction to various alarm symptoms].
Topics: Aged; Angina Pectoris; Chest Pain; Emergencies; Emergency Service, Hospital; Female; Humans; Male; M | 2003 |
[When hypertension becomes an emergency case: lower the blood pressure, but slowly!].
Topics: Administration, Oral; Antihypertensive Agents; Calcium Channel Blockers; Clonidine; Diagnosis, Diffe | 2003 |
Sexual activity in patients with angina.
Topics: Angina Pectoris; Emergencies; Erectile Dysfunction; Humans; Male; Nitroglycerin; Phosphodiesterase I | 2003 |
[Emergencies seminar: acute pulmonary edema].
Topics: Acute Disease; Analgesics, Opioid; Calcium Channel Blockers; Cardiotonic Agents; Diagnosis, Differen | 2003 |
Drug labelling and a near miss in the labour suite.
Topics: Adult; Canada; Cesarean Section; Delivery Rooms; Dose-Response Relationship, Drug; Drug Labeling; Em | 2004 |
The pharmacology of recommended medical emergency drugs.
Topics: Adrenal Cortex Hormones; American Dental Association; Ammonia; Anticonvulsants; Aspirin; Bronchodila | 2004 |
Management of medical emergencies in the dental office: conditions in each country, the extent of treatment by the dentist.
Topics: Adrenal Cortex Hormones; Albuterol; Analgesics, Opioid; Anti-Allergic Agents; Anticonvulsants; Aspir | 2006 |
Attitudes of Ohio dentists and dental hygienists on the use of automated external defibrillators.
Topics: Arrhythmias, Cardiac; Attitude of Health Personnel; Cardiopulmonary Resuscitation; Defibrillators; D | 2007 |
A true emergency?
Topics: Aged; Cardiac Catheterization; Chest Pain; Coronary Angiography; Coronary Vasospasm; Diagnosis, Diff | 2008 |
Acute occlusion after percutaneous transluminal coronary angioplasty--a new approach.
Topics: Acute Disease; Angioplasty, Balloon; Arterial Occlusive Diseases; Coronary Artery Bypass; Coronary V | 1983 |
[Emergency myocardial revascularization by intracoronary fibrinolysis. Methodological aspects and the immediate results].
Topics: Adult; Aged; Cardiac Catheterization; Coronary Angiography; Creatine Kinase; Dexamethasone; Drug Eva | 1983 |
[The role of vasodilator agents in the emergency treatment of heart failure].
Topics: Aged; Captopril; Emergencies; Female; Heart Failure; Humans; Male; Nitroglycerin; Nitroprusside; Phe | 1983 |
Emergency department treatment of esophageal obstruction.
Topics: Administration, Oral; Airway Obstruction; Emergencies; Esophageal Stenosis; Female; Humans; Middle A | 1980 |
Complications in the prehospital use of nitroglycerin.
Topics: Diagnostic Errors; Emergencies; Humans; Hypotension; Male; Middle Aged; Nitroglycerin; Pulmonary Ede | 1982 |
Distal vasoconstriction following coronary angioplasty--comparison of emergent and elective PTCA.
Topics: Aged; Angioplasty, Balloon, Coronary; Coronary Vessels; Emergencies; Female; Humans; Isosorbide Dini | 1995 |
The use of intravenous nitroglycerin for emergency cervico-uterine relaxation.
Topics: Adult; Anesthesia, General; Anesthesia, Obstetrical; Cervix Uteri; Emergencies; Female; Humans; Inje | 1995 |
Intravenous nitroglycerin boluses in treating patients with cardiogenic pulmonary edema.
Topics: Aged; Aged, 80 and over; Blood Pressure; Emergencies; Female; Humans; Infusions, Intravenous; Male; | 1995 |
Guidelines for the use of emergency drugs.
Topics: Adrenal Cortex Hormones; Ammonia; Analgesics; Anti-Arrhythmia Agents; Anticonvulsants; Bronchodilato | 1993 |
[Acute lung edema (cardiogenic and lesional). Physiopathology, diagnosis, dosage to be used in emergency treatment].
Topics: Acute Disease; Diuretics; Dose-Response Relationship, Drug; Emergencies; Heart Diseases; Humans; Nit | 1994 |
Bolus i.v. nitroglycerin treatment of ischemic chest pain in the ED.
Topics: Administration, Sublingual; Adult; Aged; Aged, 80 and over; Angina, Unstable; Blood Pressure; Emerge | 1994 |
Safety of prehospital nitroglycerin.
Topics: Administration, Sublingual; Adult; Aged; Aged, 80 and over; Bradycardia; Emergencies; Emergency Medi | 1994 |
Pharmacologic profiles of primary emergency drugs.
Topics: Ammonia; Dental Offices; Drug Therapy; Emergencies; Epinephrine; Glucose; Humans; Nitroglycerin; Oxy | 1993 |
[The efficacy of nitrate solutions in emergency states].
Topics: Angina Pectoris; Drug Evaluation; Emergencies; Humans; Infusions, Intravenous; Isosorbide Dinitrate; | 1993 |
[Intravenous use of nitroglycerin in obstetrical emergencies. 9 cases of version by internal manipulations].
Topics: Emergencies; Female; Humans; Injections, Intravenous; Nitroglycerin; Pregnancy; Pregnancy Complicati | 1996 |
Reduction in angioplasty complications after the introduction of coronary stents: results from a consecutive series of 2242 patients.
Topics: Angina, Unstable; Angioplasty, Balloon, Coronary; Coronary Artery Bypass; Coronary Disease; Coronary | 1996 |
[Intravenous use of nitroglycerin for emergency relaxation of the cervix and uterus. A case report].
Topics: Adult; Emergencies; Female; Fetal Membranes, Premature Rupture; Humans; Injections, Intravenous; Nit | 1996 |
The use of intravenous nitroglycerin for emergency cervico-uterine relaxation.
Topics: Adult; Cervix Uteri; Emergencies; Female; Humans; Injections, Intravenous; Muscle Relaxation; Muscle | 1997 |
Emergency medicine: beyond the basics.
Topics: Angina Pectoris; Chest Pain; Contraindications; Dentistry; Drug Hypersensitivity; Emergencies; Epine | 1997 |
[Diagnostic and therapeutic procedures by doctors for patients in a hypertensive crisis. An inquiry in 56 internal medicine clinics].
Topics: Acute Disease; Administration, Sublingual; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists | 1998 |
Medical emergencies in general dental practice in Great Britain. Part 2: Drugs and equipment possessed by GDPs and used in the management of emergencies.
Topics: Adrenergic Agonists; Albuterol; Anesthesia, Dental; Anesthesia, General; Bronchodilator Agents; Card | 1999 |
[Role of nitrates in the treatment of ischemia].
Topics: Angina Pectoris; Coronary Disease; Emergencies; Humans; Hypotension, Orthostatic; Isosorbide Dinitra | 2000 |
[Blood pressure exceedingly high. Nitro spray helps resolve the crisis].
Topics: Administration, Inhalation; Emergencies; Humans; Hypertension; Nitroglycerin; Vasodilator Agents | 2000 |
[Hypertensive crisis, hypertensive emergency. Nitrate spray and ambulance--this can also be wrong].
Topics: Administration, Oral; Aerosols; Ambulances; Emergencies; Female; Humans; Hypertension, Malignant; Ni | 2001 |
Effect of sublingual nitroglycerin in emergency treatment of severe pulmonary edema.
Topics: Administration, Oral; Blood Pressure; Drug Evaluation; Dyspnea; Emergencies; Heart Rate; Humans; Myo | 1978 |
Emergency tips.
Topics: Catheterization, Peripheral; Child; Diagnosis, Differential; Edema; Emergencies; Epididymitis; Genit | 1991 |
A possible acute MI: what location and type?
Topics: Aspirin; Coronary Angiography; Coronary Disease; Drug Therapy, Combination; Electrocardiography; Eme | 1991 |
Hyperventilation-induced coronary vasospasm refractory to intracoronary nitroglycerin.
Topics: Adult; Angioplasty, Balloon, Coronary; Coronary Angiography; Coronary Vasospasm; Electrocardiography | 1990 |
The new standards and guidelines for C.P.R.
Topics: Acidosis; Airway Obstruction; Atropine; Dental Offices; Emergencies; Epinephrine; Humans; Morphine; | 1990 |
[The urgency of coronary angioplasty in unstable angina].
Topics: Adult; Angina Pectoris; Angina, Unstable; Angioplasty, Balloon; Combined Modality Therapy; Death, Su | 1985 |
Current concepts in treatment of hypertensive emergencies.
Topics: Diazoxide; Drug Therapy, Combination; Emergencies; Humans; Hydralazine; Hypertension; Labetalol; Met | 1986 |
[Acute coronary angiography in therapy-refractory angina pectoris].
Topics: Adult; Aged; Angina Pectoris; Angina, Unstable; Combined Modality Therapy; Coronary Angiography; Cor | 1986 |
Comparison of nitroglycerin, morphine and furosemide in treatment of presumed pre-hospital pulmonary edema.
Topics: Aged; Drug Therapy, Combination; Emergencies; Female; Furosemide; Humans; Male; Middle Aged; Morphin | 1987 |