nitroglycerin has been researched along with Drug Withdrawal Symptoms in 33 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The hemodynamic effects of intermittent and continuous treatment with transdermal nitroglycerin, 10 mg/24 hours, were compared in 10 patients with chronic congestive heart failure (CHF)." | 9.06 | Hemodynamic effects of intermittent transdermal nitroglycerin in chronic congestive heart failure. ( Coxon, R; Luke, R; Sharpe, N; Webster, M, 1987) |
| "The potential hazards of abrupt withdrawal of propranolol have been described in patients with angina pectoris; however, the effects of abrupt withdrawal from long-term therapy with verapamil have not previously been investigated." | 9.05 | Comparative effects of abrupt withdrawal of propranolol and verapamil in angina pectoris. ( Cohen, MN; Frishman, WH; Iorio, L; Klein, N; Klein, P; LeJemtel, T; Pollack, S; Roth, S; Shamoon, H; Sonnenblick, EH; Strom, J; Willens, H, 1982) |
| "To clarify the continuing controversy concerning the use of transdermal nitroglycerin (TDN), the shortterm hemodynamic responses to sublingual, oral and transcutaneous nitrates were evaluated and compared in 22 patients with severe chronic congestive heart failure." | 7.67 | Hemodynamic factors limiting the response to transdermal nitroglycerin in severe chronic congestive heart failure. ( Lee, WH; Medina, N; Packer, M; Yushak, M, 1986) |
| "In a single-blind study of 6 weeks' duration, 32 patients with stable angina pectoris, who had been receiving controlled-release, Durules, isosorbide-5-mononitrate (Imdur) 60 to 180 mg daily for at least 1 year, were assessed after abrupt withdrawal of the nitrate." | 7.67 | Abrupt withdrawal of isosorbide-5-mononitrate in Durules (Imdur) after long term treatment in patients with stable angina pectoris. ( Aberg, A; Engvall, J; Keyriläinen, O; Nyberg, G; Olsson, G; Rehnqvist, N; Reinikainen, P; Rosenqvist, U; Ulvenstam, G; Uusitalo, A, 1988) |
| "A case of acute transmural anterior myocardial infarction in a 45-year-old Black employee of an explosives factory during a period of withdrawal from industrial nitroglycerin is documented." | 7.66 | Acute myocardial infarction due to coronary vasospasm secondary to industrial nitroglycerin withdrawal. A case report. ( Heyns, MH; Przybojewski, JZ, 1983) |
| "Clonidine was administered as a bolus injection of 1-2 micrograms/kg body weight and repeated every 1-3 h." | 5.27 | Intravenous clonidine treatment in acute myocardial infarction (with comparison to a nitroglycerin-treated and control group). ( Lada, W; Zochowski, RJ, 1986) |
| "The hemodynamic effects of intermittent and continuous treatment with transdermal nitroglycerin, 10 mg/24 hours, were compared in 10 patients with chronic congestive heart failure (CHF)." | 5.06 | Hemodynamic effects of intermittent transdermal nitroglycerin in chronic congestive heart failure. ( Coxon, R; Luke, R; Sharpe, N; Webster, M, 1987) |
| "The potential hazards of abrupt withdrawal of propranolol have been described in patients with angina pectoris; however, the effects of abrupt withdrawal from long-term therapy with verapamil have not previously been investigated." | 5.05 | Comparative effects of abrupt withdrawal of propranolol and verapamil in angina pectoris. ( Cohen, MN; Frishman, WH; Iorio, L; Klein, N; Klein, P; LeJemtel, T; Pollack, S; Roth, S; Shamoon, H; Sonnenblick, EH; Strom, J; Willens, H, 1982) |
| "To clarify the continuing controversy concerning the use of transdermal nitroglycerin (TDN), the shortterm hemodynamic responses to sublingual, oral and transcutaneous nitrates were evaluated and compared in 22 patients with severe chronic congestive heart failure." | 3.67 | Hemodynamic factors limiting the response to transdermal nitroglycerin in severe chronic congestive heart failure. ( Lee, WH; Medina, N; Packer, M; Yushak, M, 1986) |
| "In a single-blind study of 6 weeks' duration, 32 patients with stable angina pectoris, who had been receiving controlled-release, Durules, isosorbide-5-mononitrate (Imdur) 60 to 180 mg daily for at least 1 year, were assessed after abrupt withdrawal of the nitrate." | 3.67 | Abrupt withdrawal of isosorbide-5-mononitrate in Durules (Imdur) after long term treatment in patients with stable angina pectoris. ( Aberg, A; Engvall, J; Keyriläinen, O; Nyberg, G; Olsson, G; Rehnqvist, N; Reinikainen, P; Rosenqvist, U; Ulvenstam, G; Uusitalo, A, 1988) |
| " The administration of intravenous ergonovine did not provoke ST-segment shifts or arrhythmias." | 3.67 | Coronary artery spasm after abrupt withdrawal of nitroglycerin in rabbits. ( Cook, L; Reeves, WC; Whitesell, L; Wood, MA, 1985) |
| "A case of acute transmural anterior myocardial infarction in a 45-year-old Black employee of an explosives factory during a period of withdrawal from industrial nitroglycerin is documented." | 3.66 | Acute myocardial infarction due to coronary vasospasm secondary to industrial nitroglycerin withdrawal. A case report. ( Heyns, MH; Przybojewski, JZ, 1983) |
| "Nitroglycerin infusion also was accompanied by a transient increase in plasma renin activity." | 1.29 | Long-term angiotensin-converting enzyme inhibition with high-dose enalapril retards nitrate tolerance in large epicardial arteries and prevents rebound coronary vasoconstriction in vivo. ( Bassenge, E; Münzel, T, 1996) |
| "In retrospect, the cardiac arrest as well as previous complaints of chest pains during weekends fit the syndrome of withdrawal from occupational exposure to nitroglycerin." | 1.28 | Cardiac arrest in an explosives factory worker due to withdrawal from nitroglycerin exposure. ( Ben-David, A, 1989) |
| " The LD50 value for adrenaline in control animals was 11." | 1.27 | Adrenaline toxicity in mice: sensitization of alpha 1 adrenoreceptors by nitroglycerin. ( Axelsson, KL; Rydell, EL, 1984) |
| "Clonidine was administered as a bolus injection of 1-2 micrograms/kg body weight and repeated every 1-3 h." | 1.27 | Intravenous clonidine treatment in acute myocardial infarction (with comparison to a nitroglycerin-treated and control group). ( Lada, W; Zochowski, RJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (72.73) | 18.7374 |
| 1990's | 6 (18.18) | 18.2507 |
| 2000's | 3 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ruotsalainen, H | 1 |
| Rydell, EL | 1 |
| Axelsson, KL | 1 |
| Ross, PJ | 1 |
| Lewis, MJ | 2 |
| Sheridan, DJ | 1 |
| Henderson, AH | 2 |
| Singh, H | 1 |
| Rimmer, A | 1 |
| Przybojewski, JZ | 2 |
| Heyns, MH | 2 |
| Wilkinson, CJ | 1 |
| Sanders, JH | 1 |
| Halawa, B | 1 |
| Frishman, WH | 1 |
| Klein, N | 1 |
| Strom, J | 1 |
| Cohen, MN | 1 |
| Shamoon, H | 1 |
| Willens, H | 1 |
| Klein, P | 1 |
| Roth, S | 1 |
| Iorio, L | 1 |
| LeJemtel, T | 1 |
| Pollack, S | 1 |
| Sonnenblick, EH | 1 |
| Ferratini, M | 1 |
| Münzel, T | 1 |
| Bassenge, E | 1 |
| Kutishenko, NP | 2 |
| Martsevich, SIu | 2 |
| Metelitsa, VI | 2 |
| Capasso, A | 1 |
| Sorrentino, L | 1 |
| Pinto, A | 1 |
| Greiner, DZ | 1 |
| Personius, BE | 1 |
| Andrews, TC | 1 |
| Azevedo, ER | 1 |
| Schofield, AM | 1 |
| Kelly, S | 1 |
| Parker, JD | 1 |
| RuDusky, BM | 1 |
| Gerber, JG | 1 |
| Nies, AS | 1 |
| Morton, WE | 1 |
| Muller, JE | 1 |
| Gunther, SJ | 1 |
| Klock, JC | 1 |
| Zochowski, RJ | 1 |
| Lada, W | 1 |
| Ben-David, A | 1 |
| Packer, M | 1 |
| Medina, N | 1 |
| Yushak, M | 1 |
| Lee, WH | 1 |
| Sharpe, N | 1 |
| Coxon, R | 1 |
| Webster, M | 1 |
| Luke, R | 1 |
| Reeves, WC | 2 |
| Murthy, VS | 1 |
| Holt, GW | 1 |
| Christensen, CW | 1 |
| Rehnqvist, N | 1 |
| Olsson, G | 1 |
| Engvall, J | 1 |
| Rosenqvist, U | 1 |
| Nyberg, G | 1 |
| Aberg, A | 1 |
| Ulvenstam, G | 1 |
| Uusitalo, A | 1 |
| Keyriläinen, O | 1 |
| Reinikainen, P | 1 |
| Cook, L | 1 |
| Wood, MA | 1 |
| Whitesell, L | 1 |
| Schweisheimer, W | 1 |
| Alderman, EL | 1 |
| Coltart, DJ | 1 |
| Wettach, GE | 1 |
| Harrison, DC | 1 |
| Lange, RL | 1 |
| Reid, MS | 1 |
| Tresch, DD | 1 |
| Keelan, MH | 1 |
| Bernhard, VM | 1 |
| Coolidge, G | 1 |
| Lund, RP | 1 |
| Häggendal, J | 1 |
| Johnsson, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335] | Phase 2 | 10 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in mean SBP after clonidine injection | Change in DBP after clonidine injection | |
| Intrathecal Clonidine | 79 | 37 |
Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.
| Intervention | cm (Mean) | |
|---|---|---|
| Change in level of sedation | Change in sensation of dry mouth | |
| Intrathecal Clonidine | 3.36 | 3.47 |
Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Pre-injection average Likert score | Post-injection average Likert score | |
| Intrathecal Clonidine | 6.5 | 3.6 |
4 reviews available for nitroglycerin and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
[Complications associated with sudden withdrawal of various drugs used in the treatment of cardiovascular diseases].
Topics: Cardiovascular Diseases; Clonidine; Guanethidine; Humans; Nitroglycerin; Nitroprusside; Propranolol; | 1981 |
Risk of rebound phenomenon during nitrate withdrawal.
Topics: Angina Pectoris; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Administration S | 1994 |
Occupational habituation to aliphatic nitrates and the withdrawal hazards of coronary disease and hypertension.
Topics: Animals; Coronary Disease; Environmental Exposure; Humans; Hypertension; Nitrates; Nitroglycerin; Oc | 1977 |
[The nitrate withdrawal syndrome. A review of the literature and the data from the authors' own research].
Topics: Angina Pectoris; Electrocardiography; Exercise Test; Humans; Nitrates; Nitroglycerin; Physical Exert | 1992 |
3 trials available for nitroglycerin and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Comparative effects of abrupt withdrawal of propranolol and verapamil in angina pectoris.
Topics: Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Catecholamines; Clinical Trials as Topic; | 1982 |
Nitroglycerin withdrawal increases endothelium-dependent vasomotor response to acetylcholine.
Topics: Acetylcholine; Administration, Cutaneous; Coronary Angiography; Coronary Circulation; Coronary Disea | 2001 |
Hemodynamic effects of intermittent transdermal nitroglycerin in chronic congestive heart failure.
Topics: Administration, Cutaneous; Adult; Aged; Drug Administration Schedule; Drug Tolerance; Female; Heart | 1987 |
26 other studies available for nitroglycerin and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
[Girl with asthma suffering from nicotine craving and feeling dizzy].
Topics: Acute Disease; Adolescent; Asthma; Dizziness; Female; Humans; Medication Errors; Nicotine; Nitroglyc | 2003 |
Adrenaline toxicity in mice: sensitization of alpha 1 adrenoreceptors by nitroglycerin.
Topics: Angina Pectoris; Animals; Coronary Vessels; Epinephrine; Humans; Male; Mice; Mice, Inbred Strains; N | 1984 |
Adrenergic hypersensitivity after beta-blocker withdrawal.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Heart Rate; Humans; Hyperthyroidism; Male; Nitroglycer | 1981 |
beta-Adrenoceptor hypersensitivity after stopping oxprenolol: discrepant findings not attributable to methodology.
Topics: Adult; Heart Rate; Humans; Male; Nitroglycerin; Oxprenolol; Receptors, Adrenergic, beta; Substance W | 1983 |
Acute coronary vasospasm secondary to industrial nitroglycerin withdrawal. A case presentation and review.
Topics: Acute Disease; Adult; Cardiac Catheterization; Coronary Vasospasm; Electrocardiography; Humans; Male | 1983 |
Acute myocardial infarction due to coronary vasospasm secondary to industrial nitroglycerin withdrawal. A case report.
Topics: Coronary Vasospasm; Humans; Male; Middle Aged; Myocardial Infarction; Nitroglycerin; Occupational Di | 1983 |
Massive doses of nitroglycerin in a patient with variant angina.
Topics: Angina Pectoris; Angina Pectoris, Variant; Blood Pressure; Cardiopulmonary Bypass; Coronary Disease; | 1980 |
Long-term angiotensin-converting enzyme inhibition with high-dose enalapril retards nitrate tolerance in large epicardial arteries and prevents rebound coronary vasoconstriction in vivo.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Coronary Circulation; Coronary Vessels; Dogs; Dru | 1996 |
[The possibility of the development of isosorbide dinitrate and nifedipine withdrawal syndromes in patients with stable stenocardia of effort].
Topics: Adult; Aged; Angina Pectoris; Exercise Tolerance; Humans; Isosorbide Dinitrate; Male; Middle Aged; N | 1997 |
The role of nitric oxide in the development of opioid withdrawal induced by naloxone after acute treatment with mu- and kappa-opioid receptor agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylchol | 1998 |
Effects of withdrawal of chronic estrogen therapy on brachial artery vasoreactivity in women with coronary artery disease.
Topics: Administration, Oral; Aged; Brachial Artery; Coronary Disease; Endothelium, Vascular; Estradiol; Est | 1999 |
Acute myocardial infarction secondary to coronary vasospasm during withdrawal from industrial nitroglycerin exposure--a case report.
Topics: Adult; Coronary Vasospasm; Humans; Male; Myocardial Infarction; Nitroglycerin; Occupational Exposure | 2001 |
Abrupt withdrawal of cardiovascular drugs.
Topics: Cardiovascular Agents; Clonidine; Hemodynamics; Homeostasis; Humans; Nitroglycerin; Nitroprusside; P | 1979 |
Nifedipine therapy for Prinzmetal's angina.
Topics: Adult; Angina Pectoris; Angina Pectoris, Variant; Coronary Disease; Humans; Male; Myocardial Infarct | 1978 |
Nonocclusive coronary disease after chronic exposure to nitrates: evidence for physiologic nitrate dependence.
Topics: Administration, Oral; Adult; Coronary Angiography; Coronary Disease; Electrocardiography; Environmen | 1975 |
Intravenous clonidine treatment in acute myocardial infarction (with comparison to a nitroglycerin-treated and control group).
Topics: Adult; Aged; Arrhythmias, Cardiac; Catecholamines; Clonidine; Female; Humans; Male; Middle Aged; Myo | 1986 |
Cardiac arrest in an explosives factory worker due to withdrawal from nitroglycerin exposure.
Topics: Adult; Heart Arrest; Humans; Male; Nitroglycerin; Occupational Diseases; Substance Withdrawal Syndro | 1989 |
Hemodynamic factors limiting the response to transdermal nitroglycerin in severe chronic congestive heart failure.
Topics: Administration, Oral; Administration, Topical; Adult; Aged; Blood Pressure; Cardiac Output; Dose-Res | 1986 |
Evaluation of myocardial perfusion and coronary vascular resistance following withdrawal of chronic nitroglycerin treatment in rabbits.
Topics: Animals; Coronary Circulation; Electrocardiography; Ergonovine; Heart Conduction System; Indomethaci | 1987 |
Nitrate therapy in stable angina pectoris.
Topics: Angina Pectoris; Bradycardia; Humans; Hypotension; Nitrates; Nitroglycerin; Substance Withdrawal Syn | 1988 |
Abrupt withdrawal of isosorbide-5-mononitrate in Durules (Imdur) after long term treatment in patients with stable angina pectoris.
Topics: Acute Disease; Aged; Angina Pectoris; Delayed-Action Preparations; Drug Tolerance; Female; Humans; I | 1988 |
Coronary artery spasm after abrupt withdrawal of nitroglycerin in rabbits.
Topics: Animals; Arrhythmias, Cardiac; Coronary Vasospasm; Electrocardiography; Ergonovine; Humans; Indometh | 1985 |
[Progress in American medicine. Current successes, current problems].
Topics: Adult; Cryosurgery; Electric Stimulation; Electronics, Medical; Female; Fractures, Ununited; Heart D | 1974 |
Coronary artery syndromes after sudden propranolol withdrawal.
Topics: Adult; Aged; Angina Pectoris; Death, Sudden; Electrocardiography; Humans; Male; Middle Aged; Myocard | 1974 |
Nonatheromatous ischemic heart disease following withdrawal from chronic industrial nitroglycerin exposure.
Topics: Adult; Aspartate Aminotransferases; Bundle-Branch Block; Cineangiography; Coronary Disease; Electroc | 1972 |
Withdrawal symptoms in workers exposed to nitroglycerine.
Topics: Adult; Angina Pectoris; Chemical Industry; Death, Sudden; Diagnosis, Differential; Environmental Exp | 1968 |