nitroglycerin has been researched along with Disease Models, Animal in 243 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Nimesulide is a preferential COX-2 inhibitor widely used to treat pain." | 9.10 | Central components of the analgesic/antihyperalgesic effect of nimesulide: studies in animal models of pain and hyperalgesia. ( Greco, R; Nappi, G; Sandrini, G; Tassorelli, C, 2003) |
| " Treatment with GLP-1R agonist liraglutide attenuated trigeminal allodynia and suppressed the protein levels of CM-associated molecules in the trigeminal nucleus caudalis (TNC)." | 8.31 | GLP-1R agonist liraglutide attenuates pain hypersensitivity by stimulating IL-10 release in a nitroglycerin-induced chronic migraine mouse model. ( Jing, F; Pu, Y; Zou, Q, 2023) |
| "This study aimed to investigate the antimigraine potential of quercetin in migraine pain induced by nitroglycerin (NTG), 10 mg/kg, intraperitoneal injection in rats." | 8.12 | Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators. ( Alam, A; Almalki, HS; Alqarni, MH; Devi, S; Foudah, AI; Kumar, M; Salkini, MA, 2022) |
| "Rabbits with dyslipidemia were produced and randomly assigned into untreated, atorvastatin, nitroglycerin and combined groups (n=10 in each group)." | 7.83 | Atorvastatin Combined Nitroglycerin Therapy Confer Additive Effects on Rabbits with Dyslipidemia. ( Cui, L; Li, F; Wang, J; Yang, F, 2016) |
| "The essential use of riboflavin is the prevention of migraine headaches, although its effect on migraines is considered to be associated with the increased mitochondrial energy metabolism." | 7.81 | Riboflavin and vitamin E increase brain calcium and antioxidants, and microsomal calcium-ATP-ase values in rat headache models induced by glyceryl trinitrate. ( Bütün, A; Çelik, Ö; Demirci, S; Nazıroğlu, M; Uğuz, AC, 2015) |
| " On day 11, hypertension was induced by continuous angiotensin II infusion." | 7.80 | M-atrial natriuretic peptide and nitroglycerin in a canine model of experimental acute hypertensive heart failure: differential actions of 2 cGMP activating therapeutics. ( Burnett, JC; Cataliotti, A; Chen, HH; Ichiki, T; McKie, PM; Sangaralingham, SJ, 2014) |
| "To evaluate the impact of resveratrol on coronary collateral circulation in pigs suffered from experimental acute coronary occlusion." | 7.77 | [Resveratrol improves coronary collateral circulation in pigs with experimental acute coronary occlusion]. ( Wang, ZR; Xie, W; Xu, W; Zhang, CQ; Zhang, ZQ; Zhou, XF; Zhou, ZF, 2011) |
| "Nitroglycerin only has a limited late preconditioning protective effect in conscious animals submitted to a reversible prolonged ischemia since it protects against arrhythmias but not against stunning." | 7.74 | Nitroglycerin induces late preconditioning against arrhythmias but not stunning in conscious sheep. ( Lascano, EC; Negroni, JA; Valle, HF, 2007) |
| "Acute hemodynamic effects of beraprost sodium were tested in a canine vasoconstrictive pulmonary hypertension model induced by the continuous infusion of U-46619, a thromboxane A(2)mimetic." | 7.71 | Comparative effects of beraprost, a stable analogue of prostacyclin, with PGE(1), nitroglycerin and nifedipine on canine model of vasoconstrictive pulmonary hypertension. ( Kurumatani, H; Matsushita, T; Tamura, M, 2001) |
| "Comparative hemodynamic effects of nicorandil (NCR), nitroglycerin (NTG) and cromakalim (CRM) were examined in a canine model of acute congestive heart failure (CHF)." | 7.70 | Beneficial hemodynamic effects of nicorandil in a canine model of acute congestive heart failure: comparison with nitroglycerin and cromakalim. ( Koyama, T; Matsuzaki, T; Nakasone, J; Noguchi, K; Ojiri, Y; Sakanashi, M, 1998) |
| " Data were collected at baseline, after induction of heart failure (microsphere embolization into the left coronary artery), and then after toborinone boluses of 0." | 7.70 | Acute effects of toborinone on vascular capacitance and conductance in experimental heart failure. ( Belenkie, I; Semeniuk, LM; Tyberg, JV, 1998) |
| "We performed this study to demonstrate the experimental procedure for inducing pulmonary edema by angiotensin II (AT II) in rats and to determine the mechanism of hemodynamic pulmonary edema." | 7.69 | Pulmonary edema induced by angiotensin II in rats. ( Mineshita, S; Miyazaki, M; Sanaka, M; Shimakura, K; Wang, L, 1995) |
| "Adding NTG to a thrombolytic regimen with rt-PA, aspirin and heparin increases the magnitude of restored flow and total patency duration following recanalization in a rabbit model of arterial thrombosis." | 7.69 | Beneficial effect of nitroglycerin on arterial rethrombosis after thrombolysis. Results from a rabbit thrombosis model. ( Battler, A; Chernine, A; Hasdai, D; Kornowski, R; Ovadia, Z, 1995) |
| "A new experimental model of acute congestive heart failure was established in open-chest dogs, and it was employed to examine the effects of dobutamine, propranolol and nitroglycerin." | 7.69 | The effects of dobutamine, propranolol and nitroglycerin on an experimental canine model of congestive heart failure. ( Kamijo, T; Kido, H; Miwa, AY; Nakamura, F; Sugimoto, T; Tomaru, T; Uchida, Y, 1994) |
| " In this study, we compared the effects of S-nitroso N-acetyl penicillamine (SNAP) and nitroglycerin (NTG) on left ventricular (LV) hemodynamics in congestive heart failure rats." | 7.68 | Differential hemodynamic effects and tolerance properties of nitroglycerin and an S-nitrosothiol in experimental heart failure. ( Bauer, JA; Fung, HL, 1991) |
| " To determine whether ANF reduces cardiac preload through venodilation in congestive heart failure (CHF), we compared the hemodynamic effects of ANF-(99-126) with those of the venodilator nitroglycerin in conscious rats with CHF induced by coronary artery ligation previously." | 7.67 | Different hemodynamic effects of atrial natriuretic factor and nitroglycerin in rats with congestive heart failure. ( Chien, YW; Frohlich, ED; Trippodo, NC, 1989) |
| "The radioactive microsphere technique was used to trace regional blood flow and total cardiac output distribution in rats in heart failure secondary to biventricular volume overload during acute intravenous infusion of nitroglycerin." | 7.66 | Mechanism of action of nitroglycerin during exercise in a rat model of heart failure. Improvement of blood flow to the renal, splanchnic, and cutaneous beds. ( Flaim, SF; Weitzel, RL; Zelis, R, 1981) |
| "The effects of intravenous nitroglycerin (NG; 2, 8, 32 micrograms/kg) on cardiocirculatory dynamics were evaluated in control normal (C) and chronically volume-overloaded [high-output heart failure (aortocaval fistula), HCO] conscious rats." | 7.66 | Peripheral vascular effects of nitroglycerin in a conscious rat model of heart failure. ( Flaim, SF, 1982) |
| "An experimental model of angina pectoris has been developed in order to study the hemodynamic, metabolic and electrophysiological alterations of the heart assumed to occur in the human disease and to analyze the influence of nitroglycerin and dipyridamole on the above changes." | 7.65 | Nitroglycerin and dipyridamole on cardiac metabolism and dynamics in a new experimental model of angina pectoris. ( Csik, V; Szekeres, L; Udvary, E, 1976) |
| "Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models." | 6.61 | Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back. ( Borsook, D; De Icco, R; Demartini, C; Greco, R; Sances, G; Tassorelli, C; Zanaboni, AM, 2019) |
| "Until two decades ago nitroglycerin was contraindicated in acute myocardial infarction (MI)." | 6.17 | Nitrates in myocardial infarction. ( Jugdutt, BI, 1994) |
| "This study shows that the antimigraine effects of DOR agonists can be separated from their proconvulsant effects." | 5.62 | A non-convulsant delta-opioid receptor agonist, KNT-127, reduces cortical spreading depression and nitroglycerin-induced allodynia. ( Asif, S; Bertels, Z; Pradhan, AA; Siegersma, K; van Rijn, RM; Witkowski, WD, 2021) |
| "Migraine is one of the most common neurological disorders characterized by recurrent attacks of typically throbbing and unilateral headaches, affecting up to 20% of the population worldwide." | 5.62 | Protein kinase Cδ as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice. ( He, Y; Kashyap, Y; Messing, RO; Shi, Z; Wang, ZJ, 2021) |
| "Chronic migraine dramatically affects the quality of life in the migraineurs." | 5.48 | Cerebrolysin attenuates hyperalgesia, photophobia, and neuroinflammation in a nitroglycerin-induced migraine model in rats. ( Erfani, M; Farajdokht, F; Karimi, P; Mahmoudi, J; Mohaddes, G; Rajabi, M; Reyhani-Rad, S; Sadigh-Eteghad, S, 2018) |
| "Topiramate treatment prevented NTG-induced changes by reversing NTG-induced hyperalgesia and allodynia, and inhibiting CGRP and c-Fos gene expression in all areas evaluated." | 5.48 | Chronic and intermittent administration of systemic nitroglycerin in the rat induces an increase in the gene expression of CGRP in central areas: potential contribution to pain processing. ( Demartini, C; Greco, R; Tassorelli, C; Zanaboni, AM, 2018) |
| "Migraine headaches are considered to be associated with increased mitochondrial energy metabolism." | 5.42 | Protective effects of riboflavin and selenium on brain microsomal Ca2+-ATPase and oxidative damage caused by glyceryl trinitrate in a rat headache model. ( Bütün, A; Çelik, Ö; Nazıroğlu, M; Uğuz, AC, 2015) |
| "Nitroglycerine was infused under pressure into the internal thoracic artery in experimental group." | 5.32 | [Changes in tissue plasminogen activator and plasminogen activator inhibitor during administration of nitroglycerine into internal thoracic artery in dogs with acute myocardial ischemia]. ( Sheng, J; Wang, CF; Wu, X; Zhu, J, 2004) |
| " We used a previously developed pharmacokinetic-pharmacodynamic (PK/PD) model of NTG tolerance in experimental heart failure to test whether dosage regimens, designed from this model, may allow avoidance of tolerance development upon continuous NTG infusion." | 5.30 | Application of pharmacodynamic modeling for designing time-variant dosing regimens to overcome nitroglycerin tolerance in experimental heart failure. ( Balthasar, JP; Bauer, JA; Fung, HL, 1997) |
| "Pulmonary hypertension was induced by an iv infusion of group B Streptococci." | 5.27 | Neither nitroglycerin nor nitroprusside selectively reduces sepsis-induced pulmonary hypertension in piglets. ( Komar, KJ; Meadow, WL; Rudinsky, BF; Strates, E, 1987) |
| " Nimesulide is a preferential COX-2 inhibitor widely used to treat pain." | 5.10 | Central components of the analgesic/antihyperalgesic effect of nimesulide: studies in animal models of pain and hyperalgesia. ( Greco, R; Nappi, G; Sandrini, G; Tassorelli, C, 2003) |
| "The cardioprotective and antithrombotic activity of molsidomine, a novel therapeutic agent for the treatment of coronary heart disease, was investigated in a series of animal models of myocardial ischemia." | 4.77 | The activity of molsidomine in experimental models of ischemic cardiac disease. ( Martorana, PA; Nitz, RE, 1985) |
| " Treatment with GLP-1R agonist liraglutide attenuated trigeminal allodynia and suppressed the protein levels of CM-associated molecules in the trigeminal nucleus caudalis (TNC)." | 4.31 | GLP-1R agonist liraglutide attenuates pain hypersensitivity by stimulating IL-10 release in a nitroglycerin-induced chronic migraine mouse model. ( Jing, F; Pu, Y; Zou, Q, 2023) |
| "Repeated administration of nitroglycerin (NTG) or levcromakalim (LEV) was conducted to stimulate human migraine-like pain and establish two types of CMMs in mice." | 4.12 | A c-Fos activation map in nitroglycerin/levcromakalim-induced models of migraine. ( Li, Z; Liu, X; Ren, X; Wang, W; Wang, Y; Wu, S; Zhang, K; Zhu, C, 2022) |
| "This study aimed to investigate the antimigraine potential of quercetin in migraine pain induced by nitroglycerin (NTG), 10 mg/kg, intraperitoneal injection in rats." | 4.12 | Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators. ( Alam, A; Almalki, HS; Alqarni, MH; Devi, S; Foudah, AI; Kumar, M; Salkini, MA, 2022) |
| "Compared with the other groups, a statistically significant difference was found in edema, inflammation, and vascular proliferation in the nitroglycerin group." | 3.96 | The effects of nitroglycerin in the zone of stasis in a rat burn model. ( Çiftçi, İ; Gündüz, M; Sekmenli, T; Uğurluoğlu, C, 2020) |
| " Then, nitroglycerin (NTG) (5 mg/kg/IP) was used to induce migraine and pain-related symptoms were recorded for 90 min." | 3.96 | Physical exercise enhances vulnerability to migraine headache associated with CGRP up-expression in trigeminal nucleus caudalis of stressed rats. ( Abbasnejad, M; Askari-Zahabi, K; Esmaeili-Mahani, S; Kooshki, R; Raoof, M; Shamsizadeh, A, 2020) |
| " This study is intended to compare the effect of administration of nitroglycerine (NTG) through ASD and intravenous injection on the ischemic injury during acute myocardial infarction (AMI)." | 3.96 | An epicardial delivery of nitroglycerine by active hydraulic ventricular support drug delivery system improves cardiac function in a rat model. ( Abbas, M; Cheng, Y; Han, L; Li, C; Li, X; Liu, Z; Mikrani, R; Naveed, M; Wang, Z; Zhou, X, 2020) |
| " Results VL-102-evoked acute and chronic mechanical cephalic and hind-paw allodynia in a dose-dependent manner, which was blocked by the migraine medications sumatriptan, propranolol, and topiramate." | 3.88 | Soluble guanylyl cyclase is a critical regulator of migraine-associated pain. ( Ben Aissa, M; Bennett, BM; Bertels, Z; Gaisina, IN; Gandhi, R; Lee, SH; Litosh, V; Moye, LS; Novack, M; Pradhan, AA; Thatcher, GR; Tipton, AF; Wang, Y, 2018) |
| "Rabbits with dyslipidemia were produced and randomly assigned into untreated, atorvastatin, nitroglycerin and combined groups (n=10 in each group)." | 3.83 | Atorvastatin Combined Nitroglycerin Therapy Confer Additive Effects on Rabbits with Dyslipidemia. ( Cui, L; Li, F; Wang, J; Yang, F, 2016) |
| "Systemic administration of nitroglycerin (NTG) consistently provokes spontaneous-like migraine attacks in migraine sufferers, and in rat it induces hyperalgesia and allodynia." | 3.83 | Ghrelin attenuates hyperalgesia and light aversion-induced by nitroglycerin in male rats. ( Babri, S; Farajdokht, F; Karimi, P; Mohaddes, G, 2016) |
| "The essential use of riboflavin is the prevention of migraine headaches, although its effect on migraines is considered to be associated with the increased mitochondrial energy metabolism." | 3.81 | Riboflavin and vitamin E increase brain calcium and antioxidants, and microsomal calcium-ATP-ase values in rat headache models induced by glyceryl trinitrate. ( Bütün, A; Çelik, Ö; Demirci, S; Nazıroğlu, M; Uğuz, AC, 2015) |
| " On day 11, hypertension was induced by continuous angiotensin II infusion." | 3.80 | M-atrial natriuretic peptide and nitroglycerin in a canine model of experimental acute hypertensive heart failure: differential actions of 2 cGMP activating therapeutics. ( Burnett, JC; Cataliotti, A; Chen, HH; Ichiki, T; McKie, PM; Sangaralingham, SJ, 2014) |
| "To evaluate the impact of resveratrol on coronary collateral circulation in pigs suffered from experimental acute coronary occlusion." | 3.77 | [Resveratrol improves coronary collateral circulation in pigs with experimental acute coronary occlusion]. ( Wang, ZR; Xie, W; Xu, W; Zhang, CQ; Zhang, ZQ; Zhou, XF; Zhou, ZF, 2011) |
| "Nitroglycerin only has a limited late preconditioning protective effect in conscious animals submitted to a reversible prolonged ischemia since it protects against arrhythmias but not against stunning." | 3.74 | Nitroglycerin induces late preconditioning against arrhythmias but not stunning in conscious sheep. ( Lascano, EC; Negroni, JA; Valle, HF, 2007) |
| "At the dose used in this experiment, topical nitroglycerin did not prevent skin necrosis, increased inflammation score, and increased serum CPK levels." | 3.71 | A controlled trial of topical nitroglycerin in a New Zealand white rabbit model of brown recluse spider envenomation. ( Bradfield, JF; Brewer, K; Carroll, RG; Lowry, BP; Meggs, WJ, 2001) |
| "Acute hemodynamic effects of beraprost sodium were tested in a canine vasoconstrictive pulmonary hypertension model induced by the continuous infusion of U-46619, a thromboxane A(2)mimetic." | 3.71 | Comparative effects of beraprost, a stable analogue of prostacyclin, with PGE(1), nitroglycerin and nifedipine on canine model of vasoconstrictive pulmonary hypertension. ( Kurumatani, H; Matsushita, T; Tamura, M, 2001) |
| "Comparative hemodynamic effects of nicorandil (NCR), nitroglycerin (NTG) and cromakalim (CRM) were examined in a canine model of acute congestive heart failure (CHF)." | 3.70 | Beneficial hemodynamic effects of nicorandil in a canine model of acute congestive heart failure: comparison with nitroglycerin and cromakalim. ( Koyama, T; Matsuzaki, T; Nakasone, J; Noguchi, K; Ojiri, Y; Sakanashi, M, 1998) |
| " Data were collected at baseline, after induction of heart failure (microsphere embolization into the left coronary artery), and then after toborinone boluses of 0." | 3.70 | Acute effects of toborinone on vascular capacitance and conductance in experimental heart failure. ( Belenkie, I; Semeniuk, LM; Tyberg, JV, 1998) |
| "We performed this study to demonstrate the experimental procedure for inducing pulmonary edema by angiotensin II (AT II) in rats and to determine the mechanism of hemodynamic pulmonary edema." | 3.69 | Pulmonary edema induced by angiotensin II in rats. ( Mineshita, S; Miyazaki, M; Sanaka, M; Shimakura, K; Wang, L, 1995) |
| "Adding NTG to a thrombolytic regimen with rt-PA, aspirin and heparin increases the magnitude of restored flow and total patency duration following recanalization in a rabbit model of arterial thrombosis." | 3.69 | Beneficial effect of nitroglycerin on arterial rethrombosis after thrombolysis. Results from a rabbit thrombosis model. ( Battler, A; Chernine, A; Hasdai, D; Kornowski, R; Ovadia, Z, 1995) |
| "A new experimental model of acute congestive heart failure was established in open-chest dogs, and it was employed to examine the effects of dobutamine, propranolol and nitroglycerin." | 3.69 | The effects of dobutamine, propranolol and nitroglycerin on an experimental canine model of congestive heart failure. ( Kamijo, T; Kido, H; Miwa, AY; Nakamura, F; Sugimoto, T; Tomaru, T; Uchida, Y, 1994) |
| "The efficacy of a controlled-release topical dosage form of glyceryl trinitrate (Nitroglycerin Transdermal Therapeutic System, Nitroderm TTS, NTG-TTS; CAS 55-63-0) was studied in the experimental model of congestive heart failure in beagles." | 3.68 | Efficacy of the glyceryl trinitrate transdermal therapeutic system in a dog model of heart failure. ( Inukai, T; Katahira, J; Nakao, K; Tanaka, M, 1991) |
| " In this study, we compared the effects of S-nitroso N-acetyl penicillamine (SNAP) and nitroglycerin (NTG) on left ventricular (LV) hemodynamics in congestive heart failure rats." | 3.68 | Differential hemodynamic effects and tolerance properties of nitroglycerin and an S-nitrosothiol in experimental heart failure. ( Bauer, JA; Fung, HL, 1991) |
| " To determine whether ANF reduces cardiac preload through venodilation in congestive heart failure (CHF), we compared the hemodynamic effects of ANF-(99-126) with those of the venodilator nitroglycerin in conscious rats with CHF induced by coronary artery ligation previously." | 3.67 | Different hemodynamic effects of atrial natriuretic factor and nitroglycerin in rats with congestive heart failure. ( Chien, YW; Frohlich, ED; Trippodo, NC, 1989) |
| "The radioactive microsphere technique was used to trace regional blood flow and total cardiac output distribution in rats in heart failure secondary to biventricular volume overload during acute intravenous infusion of nitroglycerin." | 3.66 | Mechanism of action of nitroglycerin during exercise in a rat model of heart failure. Improvement of blood flow to the renal, splanchnic, and cutaneous beds. ( Flaim, SF; Weitzel, RL; Zelis, R, 1981) |
| " However, in vitro experiments are not satisfactory to predict antiarrhythmic activity "in vivo", because: 1) they are mostly performed in preparations made from the normal myocardium; 2) "in vitro" the autonomic and hormonal effects are absent; 3) some drugs as nitroglycerin or strophanthin do not produce antiarrhythmic electrophysiological changes in "vitro" but under appropriate conditions they may have a clear-cut antiarrhythmic action "in vivo"; 4) arrhythmias mostly arise from the interaction of changes in several fundamental electrophysiological parameters which could be best studied "in vivo"." | 3.66 | [Pharmacologic evaluation of electrical processes in the myocardium]. ( Sekeresh, L, 1982) |
| "The effects of intravenous nitroglycerin (NG; 2, 8, 32 micrograms/kg) on cardiocirculatory dynamics were evaluated in control normal (C) and chronically volume-overloaded [high-output heart failure (aortocaval fistula), HCO] conscious rats." | 3.66 | Peripheral vascular effects of nitroglycerin in a conscious rat model of heart failure. ( Flaim, SF, 1982) |
| "The recent use of vasodilators to improve ventricular function in acute myocardial infarction led us to investigate the effects of nitroglycerin, nitroprusside, and phentolamine on coronary collateral flow." | 3.65 | Comparison of nitroglycerin-, nitroprusside-, and phentolamine-induced changes in coronary collateral function in dogs. ( Capurro, NL; Epstein, SE; Kent, KM, 1977) |
| "An experimental model of angina pectoris has been developed in order to study the hemodynamic, metabolic and electrophysiological alterations of the heart assumed to occur in the human disease and to analyze the influence of nitroglycerin and dipyridamole on the above changes." | 3.65 | Nitroglycerin and dipyridamole on cardiac metabolism and dynamics in a new experimental model of angina pectoris. ( Csik, V; Szekeres, L; Udvary, E, 1976) |
| "Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models." | 2.61 | Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back. ( Borsook, D; De Icco, R; Demartini, C; Greco, R; Sances, G; Tassorelli, C; Zanaboni, AM, 2019) |
| "In the paper, by taking acupuncture and migraine as the key words to retrieve CNKI and PubMed database, the literature analysis was done on the mechanism study on experimental migraine treated with acupuncture in rat model." | 2.53 | [Progression of the mechanism study on experimental migraine treated with acupuncture in rat model]. ( Liu, L; Pei, P; Wang, L, 2016) |
| "Given the nature of migraine attacks, fully reversible and treatable, the headache- or migraine-provoking property of naturally occurring signaling molecules can be tested in a human model." | 2.49 | Pearls and pitfalls in human pharmacological models of migraine: 30 years' experience. ( Ashina, M; Hansen, JM; Olesen, J, 2013) |
| "Hydralazine is an efficient reactive oxygen species (ROS) scavenger and an inhibitor of O2- generation." | 2.43 | The oxidative stress concept of nitrate tolerance and the antioxidant properties of hydralazine. ( Daiber, A; Hink, U; Mollnau, H; Mülsch, A; Münzel, T; Oelze, M; Warnholtz, A, 2005) |
| "Migraine is a recurrent primary headache disorder with moderate to severe disability; however, the pathophysiology is not fully understood." | 1.91 | Multi-region local field potential signatures and brain coherence alternations in response to nitroglycerin-induced migraine attacks. ( Lin, Q; Peng, YB; Wang, Z, 2023) |
| "In the acute migraine model, rats received CBD (15 mg or 30 mg/kg, i." | 1.91 | Characterization of the biochemical and behavioral effects of cannabidiol: implications for migraine. ( Demartini, C; Facchetti, S; Francavilla, M; Franco, V; Greco, R; Pacchetti, B; Palmisani, M; Sodergren, MH; Tassorelli, C; Zanaboni, AM, 2023) |
| "A mouse model of chronic migraine (CM) was established by repeated nitroglycerin (NTG) stimulation and evaluated by von-Frey filaments, a hot plate and a light-dark box." | 1.91 | Proteomics profiling reveals mitochondrial damage in the thalamus in a mouse model of chronic migraine. ( Gong, Z; Li, B; Li, C; Li, R; Ma, Z; Miao, S; Tang, W; Wang, T; Xie, W; Yang, C; Yu, S; Zhou, Y, 2023) |
| "Chronic migraine places a disabling burden on patients, which is extensively modeled by the nitroglycerin (NTG)-treated animal model." | 1.72 | IL-17 crosses the blood-brain barrier to trigger neuroinflammation: a novel mechanism in nitroglycerin-induced chronic migraine. ( Chen, H; Hu, B; Li, J; Ma, T; Tang, X; Xu, S; Yang, W; Zhan, M, 2022) |
| "Nitroglycerin (NTG) was used to establish a mouse migraine model, and a behaviour study was conducted by hot plate test." | 1.72 | Classical prescription Dachuanxiong Formula delays nitroglycerin-induced pain response in migraine mice through reducing endothelin-1 level and regulating fatty acid biosynthesis. ( Chen, Y; Chen, Z; Gao, C; Vong, CT; Wang, S; Wang, Y; Yang, F, 2022) |
| "Contrary to previous results with the migraine-inducing substances glyceryl trinitrate, cilostazol and levcromakalim, PACAP-38-induced hypersensitivity worked only partially through inhibition of ATP-sensitive potassium channels." | 1.72 | The PACAP pathway is independent of CGRP in mouse models of migraine: possible new drug target? ( Christensen, SL; Ernstsen, C; Jansen-Olesen, I; Kristensen, DM; Nielsen, BS; Olesen, J; Rasmussen, RH, 2022) |
| "Converging evidence shows that migraine is associated with gastrointestinal disorders." | 1.72 | Supplementation with SCFAs Re-Establishes Microbiota Composition and Attenuates Hyperalgesia and Pain in a Mouse Model of NTG-Induced Migraine. ( Campolo, M; Casili, G; Cuzzocrea, S; Esposito, E; Filippone, A; Giuffrè, L; Lanza, M; Paterniti, I; Scuderi, SA, 2022) |
| "Migraine is a complex neurovascular disorder characterized by recurrent attacks of pain and other associated symptoms." | 1.72 | Modelling migraine-related features in the nitroglycerin animal model: Trigeminal hyperalgesia is associated with affective status and motor behavior. ( Demartini, C; Francavilla, M; Greco, R; Tassorelli, C; Zanaboni, AM, 2022) |
| "The effects of exogenous HSP70 on migraine-like symptoms were assessed through behavioral assays." | 1.62 | Exogenous Hsp70 attenuates nitroglycerin-induced migraine-like symptoms in mice. ( Huang, Y; Huang, Z; Liao, J; Lin, W; Shi, C; Wei, G; Wu, F, 2021) |
| "Migraine is caused by hyperactivity of the trigeminovascular system, where trigeminal ganglia (TG) play an important role." | 1.62 | α6GABA ( Chiou, LC; Cook, J; Fan, PC; Knutson, DE; Lai, TH; Lee, MT; Sieghart, W; Tzeng, HR, 2021) |
| "With a prevalence of 15%, migraine is the most common neurological disorder and among the most disabling diseases, taking into account years lived with disability." | 1.62 | Double-Binding Botulinum Molecule with Reduced Muscle Paralysis: Evaluation in In Vitro and In Vivo Models of Migraine. ( Andreou, AP; Corrie, E; Davletov, B; Demartini, C; Doran, C; Gafurov, O; Giniatullin, R; Greco, R; Koroleva, K; Lambru, G; Leese, C; Lloyd, JO; Seward, E; Simsek, D; Tassorelli, C; Zanaboni, A, 2021) |
| "This study shows that the antimigraine effects of DOR agonists can be separated from their proconvulsant effects." | 1.62 | A non-convulsant delta-opioid receptor agonist, KNT-127, reduces cortical spreading depression and nitroglycerin-induced allodynia. ( Asif, S; Bertels, Z; Pradhan, AA; Siegersma, K; van Rijn, RM; Witkowski, WD, 2021) |
| "We use validated mouse models of migraine to show that HDAC6-inhibition is a promising migraine treatment and reveal an undiscovered cytoarchitectural basis for migraine chronicity." | 1.62 | Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition. ( Ao, M; Baca, SM; Bertels, Z; Conway, C; Dripps, I; Karumudi, B; Mangutov, E; Petukhov, PA; Petukhova, V; Pradhan, AA; Rasenick, MM; Shah, P; Sheets, Z; Siegersma, K; Singh, H; Tipton, AF; Witkowski, WD, 2021) |
| "Tissue necrosis was greatest in controls (51." | 1.62 | Quantifying the Effect of Topical Nitroglycerin on Random Pattern Flap Perfusion in a Rodent Model: An Application of the ViOptix Intra.Ox for Dynamic Flap Perfusion Assessment and Salvage. ( Darrach, H; Khavanin, N; Kraenzlin, F; Sacks, JM; Yesantharao, P, 2021) |
| "Migraine is one of the most common neurological disorders characterized by recurrent attacks of typically throbbing and unilateral headaches, affecting up to 20% of the population worldwide." | 1.62 | Protein kinase Cδ as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice. ( He, Y; Kashyap, Y; Messing, RO; Shi, Z; Wang, ZJ, 2021) |
| "In response to pulmonary embolism after acetylcholine infusion against the background of pirenzepine pretreatment, the capillary hydrostatic pressure and postcapillary resistance did not change, while after atropine treatment, these parameters increased." | 1.62 | Pulmonary Microcirculation during Experimental Pulmonary Thromboembolism under Conditions of Activation and Blockade of Muscarinic Acetylcholine Receptors. ( Berezina, TP; Evlakhov, VI; Ovsyannikov, VI; Poyassov, IZ, 2021) |
| "However, the role of PD-L1/PD-1 in migraine remains unclear." | 1.56 | PD-L1 and PD-1 expressed in trigeminal ganglia may inhibit pain in an acute migraine model. ( Guo, P; Han, Y; Ren, T; Shi, S; Wang, D; Wang, J; Wang, W, 2020) |
| "The present first-line anti-migraine medications can cause overwhelming side-effects, of which one includes the onset of cardiovascular disease." | 1.56 | Tibetan medicine Ru-yi-Zhen-bao Pills exhibits anti-migraine effect through mediating PAG anti-nociceptive channel. ( Dong, RJ; Gao, MH; Ge, DY; Li, R; Li, YR; Luo, YM; Ma, L; Ren, QJ; Ren, XQ; Song, HR; Tao, XH; Wang, CG; Yang, XQ; Zhang, SJ; Zhou, RR, 2020) |
| "5-BDBD or ANA-12 prevented hyperalgesia induced by NTG, which was associated with a significant inhibition of the NTG-induced increase in phosphorylated extracellular regulated protein kinases (p-ERK) and calcitonin gene related peptide (CGRP) release in the TNC." | 1.56 | Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model. ( Chen, L; He, W; Long, T; Pan, Q; Qin, G; Zhang, D; Zhang, S; Zhou, J, 2020) |
| "Migraine is commonly reported among patients with temporomandibular disorders (TMDs), especially myogenic TMD." | 1.56 | A Pre-Existing Myogenic Temporomandibular Disorder Increases Trigeminal Calcitonin Gene-Related Peptide and Enhances Nitroglycerin-Induced Hypersensitivity in Mice. ( Bellinger, LL; Bender, SD; Dolan, JC; Kramer, PR; Liu, S; Schmidt, BL; Shu, H; Tang, Y; Tao, F, 2020) |
| "In a model of chronic migraine-associated pain using the human migraine trigger, nitroglycerin, we observed increased expression of DOR in cortex, hippocampus, and striatum; suggesting a role for these forebrain regions in the regulation of migraine." | 1.56 | Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia. ( Baca, SM; Bertels, Z; Dripps, IJ; Kieffer, BL; Moye, LS; Pradhan, AA; Siegersma, K; Tipton, AF, 2020) |
| "The pathogenesis of medication overuse headache (MOH) involves hyperexcitability of cortical and trigeminal neurons." | 1.51 | Altered activity in the nucleus raphe magnus underlies cortical hyperexcitability and facilitates trigeminal nociception in a rat model of medication overuse headache. ( le Grand, SM; Potewiratnanond, P; Srikiatkhachorn, A; Supronsinchai, W, 2019) |
| "Nociceptors from migraine patients with the F139WfsX2 mutation show loss of functional TRESK at the membrane, with a corresponding significant increase in neuronal excitability." | 1.51 | A causal role for TRESK loss of function in migraine mechanisms. ( Arunasalam, K; Bassett, A; Cader, MZ; Cheung, J; Chintawar, S; Couper, E; Cowley, SA; Duggal, G; Flower, G; Griffiths, LR; Handel, A; Haupt, LM; Lalic, T; Pettingill, P; Wei, T; Weir, GA; Wu, Y, 2019) |
| "The NTG injection induced acute migraine-like pain including photophobia and mechanical hypersensitivity as reported previously." | 1.48 | AMPA receptor GluA1 Ser831 phosphorylation is critical for nitroglycerin-induced migraine-like pain. ( Liu, S; Shu, H; Tang, Y; Tao, F; Xing, Y, 2018) |
| "Chronic migraine dramatically affects the quality of life in the migraineurs." | 1.48 | Cerebrolysin attenuates hyperalgesia, photophobia, and neuroinflammation in a nitroglycerin-induced migraine model in rats. ( Erfani, M; Farajdokht, F; Karimi, P; Mahmoudi, J; Mohaddes, G; Rajabi, M; Reyhani-Rad, S; Sadigh-Eteghad, S, 2018) |
| "Curcumin has antioxidative properties that could be useful in various diseases due to its ability to act on multiple targets of various cellular pathways." | 1.48 | The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats. ( Bolboacă, SD; Bulboacă, AC; Bulboacă, AE; Porfire, A; Sfrângeu, CA; Stănescu, IC; Tefas, L, 2018) |
| "Topiramate treatment prevented NTG-induced changes by reversing NTG-induced hyperalgesia and allodynia, and inhibiting CGRP and c-Fos gene expression in all areas evaluated." | 1.48 | Chronic and intermittent administration of systemic nitroglycerin in the rat induces an increase in the gene expression of CGRP in central areas: potential contribution to pain processing. ( Demartini, C; Greco, R; Tassorelli, C; Zanaboni, AM, 2018) |
| " Administration of ASA increased the infarct severity; however, concomitant dosing with NTG somewhat attenuated this effect." | 1.48 | Nitroglycerin application and coronary arteriogenesis. ( Bramlage, P; Buschmann, IR; Dawid, R; Dülsner, A; Gatzke, N; Gorath, M; Güc, N; Hillmeister, P; Pagonas, N; Smith, KH, 2018) |
| "The mechanism underlying migraine chronification remains unclear." | 1.48 | Microglia P2X4 receptor contributes to central sensitization following recurrent nitroglycerin stimulation. ( Chen, L; He, W; Liu, C; Liu, Q; Long, T; Pan, Q; Qin, G; Zhang, S; Zhang, Y; Zhou, J, 2018) |
| "BAI could alleviate the migraine-like headache induced by NTG, which is related to the regulation of vasoactive substances." | 1.46 | Analgesia effect of baicalein against NTG-induced migraine in rats. ( Bao, Y; Dong, CL; Guo, CR; Hu, WL; Sun, YY; Wang, CZ; Yuan, CS; Zhang, CF; Zhang, WJ; Zhang, XF, 2017) |
| "Chronic migraine is a common debilitating disease with limited treatment options." | 1.46 | Nitroglycerin challenge induces lateralized headache in nasociliarynerve-ligated rats: implications for chronic migraine. ( Akçali, D; Babacan, A; Belen, AD; Bolay, H, 2017) |
| "The presentation of spontaneous tactile allodynia was observed in the nitroglycerin group by the 5th episode." | 1.46 | The effects of repeated nitroglycerin administrations in rats; modeling migraine-related endpoints and chronification. ( Black, JR; Carpenter, JM; Harris, HM; Smitherman, TA; Sufka, KJ, 2017) |
| " In addition, chronic administration of nitroglycerin produces a progressive and sustained decrease in basal mechanical responses, and this hypersensitivity is blocked by migraine preventatives such as topiramate." | 1.46 | Animal Model of Chronic Migraine-Associated Pain. ( Moye, LS; Pradhan, AAA, 2017) |
| "In rats bearing nitroglycerin-induced hyperalgesia, ADM_12 showed an anti-hyperalgesic effect in the second phase of the orofacial formalin test." | 1.46 | The role of the transient receptor potential ankyrin type-1 (TRPA1) channel in migraine pain: evaluation in an animal model. ( Demartini, C; Francesconi, O; Greco, R; Nativi, C; Tassorelli, C; Tonsi, G; Zanaboni, AM, 2017) |
| "Headache is a common episodic or chronic neurologic disorder." | 1.46 | Metabolomics Strategy Using High Resolution Mass Spectrometry Reveals Novel Biomarkers and Pain-Relief Effect of Traditional Chinese Medicine Prescription Wu-Zhu-Yu Decoction Acting on Headache Modelling Rats. ( Bi, K; Li, Q; Liu, R; Sui, Z; Wang, D; Wang, X; Xu, H; Yuan, Z; Zhang, X, 2017) |
| "In the present study, we aimed to elucidate the pharmacodynamic action of DL and its mechanism in an animal model of migraines induced by glyceryl trinitrate (GTN)." | 1.46 | Pharmacodynamic action and mechanism of Du Liang soft capsule, a traditional Chinese medicine capsule, on treating nitroglycerin-induced migraine. ( Chen, L; Hou, M; Liu, Y; Tang, Q; Xu, X; Xue, Q; Yang, S; Zhang, X, 2017) |
| "One of the human and animal models of migraine is the systemic administration of the nitric oxide donor (NO) nitroglycerin (NTG)." | 1.43 | The modulatory effect of anandamide on nitroglycerin-induced sensitization in the trigeminal system of the rat. ( Bohár, Z; Fejes-Szabó, A; Laborc, KF; Nagy-Grócz, G; Párdutz, Á; Spekker, E; Tar, L; Vécsei, L, 2016) |
| "Background The development of novel migraine therapies has been slow, in part because of the small number of clinically relevant animal models." | 1.43 | The effects of acute and preventive migraine therapies in a mouse model of chronic migraine. ( Charles, A; McGuire, B; Pradhan, AA; Tarash, I; Tipton, AF, 2016) |
| "We reported that hyperalgesia induced by intradermal GTN has a delay to onset of ∼ 30 min in male and ∼ 45 min in female rats." | 1.43 | Mechanisms mediating nitroglycerin-induced delayed-onset hyperalgesia in the rat. ( Ferrari, LF; Green, PG; Levine, JD, 2016) |
| "typhimurium A1-R on pancreatic cancer stem cells, on pancreatic cancer in combination with anti-angiogenic agents, as well as on cervical cancer, soft-tissue sarcoma, and pancreatic cancer patient-derived orthotopic xenograft (PDOX) mouse models, is also described." | 1.43 | Tumor-Targeting Salmonella typhimurium A1-R: An Overview. ( Hoffman, RM, 2016) |
| "Solid tumors exhibit the enhanced permeability and retention (EPR) effect for biocompatible macromolecules such as polymer-conjugated anticancer agents, liposomes, and micelles." | 1.43 | Enhancement of Tumor-Targeted Delivery of Bacteria with Nitroglycerin Involving Augmentation of the EPR Effect. ( Fang, J; Long, L; Maeda, H, 2016) |
| "Nitroglycerin (NTG) was employed to induce a migraine model in rats and the migraine animals were exposed to treatment of VPA of different doses." | 1.43 | Valproate ameliorates nitroglycerin-induced migraine in trigeminal nucleus caudalis in rats through inhibition of NF-кB. ( Li, Q; Li, Y; Qi, D; Yi, L; Zhang, L; Zhang, Q; Zhang, Z, 2016) |
| "Many migraineurs also display alterations in blink reflexes, known to involve brainstem circuits." | 1.43 | Pharmacology of reflex blinks in the rat: a novel model for headache research. ( Andreou, AP; Jones, MG; McMahon, SB; Spanswick, D, 2016) |
| "Nitroglycerin (NTG) is an organic nitrate rapidly denitrated by enzymes to release free radical nitric oxide and shows improved wound healing and tissue protection from oxidative damage." | 1.42 | Preliminary investigation of topical nitroglycerin formulations containing natural wound healing agent in diabetes-induced foot ulcer. ( Avachat, AM; Bhosale, SS; Hotkar, MS; Oswal, YM, 2015) |
| "NTG-induced hyperalgesia in rats has been extensively used as a migraine model for pre-clinical research." | 1.42 | Pregabalin alleviates the nitroglycerin-induced hyperalgesia in rats. ( Di, W; Ding, MH; Fang, YN; Lin, JW; Luo, N; Qi, WW; Shi, XL; Xiao, ZJ; Zhang, AW; Zheng, ZY, 2015) |
| "The percentage area of liver fibrosis was also significantly reduced in GTN-treated mice (5." | 1.42 | Improvement of hepatocyte transplantation efficiency in the mdr2-/- mouse model by glyceryl trinitrate. ( Boudechiche, L; Branchereau, S; Dagher, I; Davit-Spraul, A; Groyer-Picard, MT; Hadchouel, M; Laïnas, P; Tranchart, H; Weber, A, 2015) |
| "Migraine headaches are considered to be associated with increased mitochondrial energy metabolism." | 1.42 | Protective effects of riboflavin and selenium on brain microsomal Ca2+-ATPase and oxidative damage caused by glyceryl trinitrate in a rat headache model. ( Bütün, A; Çelik, Ö; Nazıroğlu, M; Uğuz, AC, 2015) |
| "Better treatments for schizophrenia are urgently needed." | 1.42 | Effects of nitric oxide-related compounds in the acute ketamine animal model of schizophrenia. ( Abrao, J; Baker, GB; Balista, PA; Chaves, C; Dursun, SM; Evora, PR; Guimaraes, FS; Hallak, JE; Kandratavicius, L; Leite, JP; Maia-de-Oliveira, JP; Rodrigues, AJ; Wolf, DC, 2015) |
| "Although migraine is a common neurological condition, the pathomechanism is not yet fully understood." | 1.42 | Role of phosphorylated extracellular signal-regulated kinase, calcitonin gene-related peptide and cyclooxygenase-2 in experimental rat models of migraine. ( Chen, J; Dong, X; Hu, Y; Jing, L, 2015) |
| "We found that nitroglycerin-induced mechanical allodynia and neuronal activation of the trigeminal nucleus were completely abolished in FAAH-deficient mice." | 1.42 | Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice. ( Markert, A; Nozaki, C; Zimmer, A, 2015) |
| "This chronic basal hyperalgesia occurred in a dose-dependent fashion and persisted for days after cessation of NTG administration." | 1.40 | Characterization of a novel model of chronic migraine. ( Charles, A; Evans, CJ; McGuire, B; Pradhan, AA; Smith, ML; Tarash, I, 2014) |
| "Donation after circulatory death (DCD) offers a potential additional source of cardiac allografts." | 1.40 | Increasing the tolerance of DCD hearts to warm ischemia by pharmacological postconditioning. ( Dhital, KK; Doyle, A; Feneley, MP; Gao, L; Graham, RM; Harvey, RP; Hicks, M; Iyer, A; Jabbour, A; Jansz, PC; Jayewardene, D; Kumarasinghe, G; Macdonald, PS; Rao, P; Wan, B, 2014) |
| "Delayed cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) is a major cause of high morbidity and mortality." | 1.37 | Continuous intrathecal glyceryl trinitrate prevents delayed cerebral vasospasm in the single-SAH rabbit model in vivo. ( Fandino, J; Fathi, AR; Graupner, T; Jakob, SM; Marbacher, S; Schroth, G; Wehrli, F, 2011) |
| "Nitroglycerine was used as preparation of comparison; it was administered in the same dose." | 1.35 | [The study of vasodilative and antiischemic function of nicorandil in regional ischemia and reperfusion of rat heart in vivo]. ( Eremenko, LT; Garanin, VA; Kosilko, VP; Nesterenko, DA; Pisarenko, OI; Serebriakova, LI; Tskitishvili, OV, 2008) |
| "nitroglycerin induced migraine Twenty Sprague-Dawley rats, 10 male and 10 female, were randomly divided into 2 groups: model group, undergoing subcutaneous injection of nitroglycerin 10 mg/kg once a week for 4 weeks so as to establish migraine model, and control group, undergoing subcutaneous injection of normal saline." | 1.35 | [Relationship between P-type Na+ -K+ -Atpase and migraine: an experimental study with rats]. ( Hu, YM; Xiao, B; Yang, XS; Zhang, CY, 2008) |
| "1." | 1.35 | Effects of 1400W and/or nitroglycerin on renal oxygenation and kidney function during endotoxaemia in anaesthetized rats. ( Dieterich, HJ; Goedhart, PT; Ince, C; Johannes, T; Klingel, K; Mik, EG; Nohé, B; Unertl, KE; Zanke, C, 2009) |
| " Although kynurenic acid does not cross the BBB, its precursor, kynurenine, if combined with probenecid, crosses it readily." | 1.34 | Kynurenine in combination with probenecid mitigates the stimulation-induced increase of c-fos immunoreactivity of the rat caudal trigeminal nucleus in an experimental migraine model. ( Chadaide, Z; Fenyo, R; Knyihár-Csillik, E; Krisztin-Péva, B; Mihály, A; Németh, H; Toldi, J; Vécsei, L, 2007) |
| "Heart failure was induced by right ventricular pacing at 240 beats/min for 3-4 wk, and cardiac recovery (CR) was allowed by the termination of cardiac pacing for 3-4 wk after the development of CHF, in which left ventricular contractile function was restored by 80-90%." | 1.34 | Restoration of impaired endothelium-dependent coronary vasodilation in failing heart: role of eNOS phosphorylation and CGMP/cGK-I signaling. ( Braz, JC; Etgen, GJ; Gill, RM; Jin, N; Shen, W, 2007) |
| " The present investigation tested the hypothesis of whether kynurenine in combination with systemically administered probenecid protects second-order trigeminal neurons against stimulation arriving via central processes of trigeminal ganglion cells." | 1.34 | Prevention of electrical stimulation-induced increase of c-fos immunoreaction in the caudal trigeminal nucleus by kynurenine combined with probenecid. ( Chadaide, Z; Fenyo, R; Knyihár-Csillik, E; Krisztin-Péva, B; Németh, H; Toldi, J; Vécsei, L, 2007) |
| "Nitroglycerin can increase gastric blood flow and slow gastric emptying." | 1.34 | Intragastric nitroglycerin at a vasodilatory dose attenuates acidified aspirin-induced gastric mucosal injury. ( Chan, CC; Leung, FW, 2007) |
| " Additional mechanisms involving blockade of Ca2+ entry in the vascular smooth muscle and increase in NO bioavailability contributes to beneficial effects of long-term propranolol treatment." | 1.34 | Vascular effects of long-term propranolol administration after chronic nitric oxide blockade. ( Antunes, E; Claudino, MA; De Nucci, G; Priviero, FB; Teixeira, CE; Zanesco, A, 2007) |
| "Our goals were to determine whether Type 1 diabetes (T1D) alters neuronal nitric oxide synthase (nNOS)-dependent reactivity of cerebral arterioles and to identify a potential role for oxidative stress in T1D-induced impairment in nNOS-dependent responses of cerebral arterioles." | 1.34 | nNOS-dependent reactivity of cerebral arterioles in Type 1 diabetes. ( Arrick, DM; Mayhan, WG; Sharpe, GM; Sun, H, 2007) |
| "Rotenone is a mitochondrial toxin which can produce Parkinson syndrome (PS) in rats." | 1.33 | Increased myocardial N-myristoyltransferase activity in rotenone model of Parkinsonism. ( Pasha, MK; Rajput, AH; Sharma, RK, 2005) |
| "One model of migraine headache is the systemic administration of nitric oxide (NO) donor nitroglycerin (NTG), which triggers a delayed attack without aura in many migraine patients but not in healthy volunteers." | 1.33 | [The modulatory effect of estrogen on the caudal trigeminal nucleus of the rat in an animal model of migraine]. ( Párdutz, A; Schoenen, J; Tajti, J; Varga, H; Vécsei, L, 2006) |
| "To date, its therapeutic actions in congestive heart failure (CHF) remain undefined." | 1.32 | Cardiorenal and humoral properties of a novel direct soluble guanylate cyclase stimulator BAY 41-2272 in experimental congestive heart failure. ( Boerrigter, G; Burnett, JC; Cataliotti, A; Costello-Boerrigter, LC; Harty, GJ; Lapp, H; Stasch, JP; Tsuruda, T, 2003) |
| "Nitroglycerin is a NO donor, which easily crosses the blood brain barrier." | 1.32 | Nitroglycerin enhances cGMP expression in specific neuronal and cerebrovascular structures of the rat brain. ( Blandini, F; Greco, R; Nappi, G; Tassorelli, C, 2004) |
| "Nitroglycerine was infused under pressure into the internal thoracic artery in experimental group." | 1.32 | [Changes in tissue plasminogen activator and plasminogen activator inhibitor during administration of nitroglycerine into internal thoracic artery in dogs with acute myocardial ischemia]. ( Sheng, J; Wang, CF; Wu, X; Zhu, J, 2004) |
| "The potential for malignancy detection using dynamic infrared imaging (DIRI) has been investigated in an animal model of human malignancy." | 1.32 | Dynamic infrared imaging for the detection of malignancy. ( Button, TM; Carvelli, P; Dulaimy, K; Fisher, P; Geronimo, C; Geronimo, V; Jambawalikar, S; Li, H; Li, S; O'Hea, B; Rosenblatt, R; Salvitti, M; Weiss, R, 2004) |
| "Nitroglycerin treatment caused endothelial dysfunction in NZWR and WHHL, associated with an increase in superoxide and ONOO(-) production and a substantial drop in cGK-I activity." | 1.31 | Adverse effects of nitroglycerin treatment on endothelial function, vascular nitrotyrosine levels and cGMP-dependent protein kinase activity in hyperlipidemic Watanabe rabbits. ( Beisiegel, U; Giaid, A; Heitzer, T; Kontush, A; Lavall, D; Marklund, SL; Meinertz, T; Möller-Bertram, T; Mollnau, H; Munzel, T; Walter, U; Warnholtz, A, 2002) |
| "2." | 1.31 | Vasopeptidase inhibition in a canine model of exercise-induced left ventricular dysfunction. ( Arthur, SR; Holzgrefe, HH; Powell, JR, 2002) |
| "Tamoxifen is a mixed estrogen agonist/antagonist with as yet unexplored effects on vascular function." | 1.30 | Contrasting effects of conjugated estrogens and tamoxifen on dilator responses of atherosclerotic epicardial coronary arteries in nonhuman primates. ( Adams, MR; Honoré, EK; Williams, JK, 1997) |
| " We used a previously developed pharmacokinetic-pharmacodynamic (PK/PD) model of NTG tolerance in experimental heart failure to test whether dosage regimens, designed from this model, may allow avoidance of tolerance development upon continuous NTG infusion." | 1.30 | Application of pharmacodynamic modeling for designing time-variant dosing regimens to overcome nitroglycerin tolerance in experimental heart failure. ( Balthasar, JP; Bauer, JA; Fung, HL, 1997) |
| "Nitroglycerin was administrated either by inhalation or by infusion." | 1.30 | Effects of inhalation of nitroglycerin on hypoxic pulmonary vasoconstriction. ( Bando, M; Ishii, Y; Kitamura, S; Ohno, S, 1998) |
| "Partial ischemia was induced in each left hind limb by surgical ligation of the common and superficial femoral arteries, leaving the internal iliac artery intact." | 1.30 | Controlled delivery of vascular endothelial growth factor promotes neovascularization and maintains limb function in a rabbit model of ischemia. ( Bowman, B; Bulgrin, JP; Donovan, DL; Hopkins, SP; Schmidt, SP; Sims, RL, 1998) |
| "4 U/kg vasopressin combined with 5 microg/kg nitroglycerin (n = 7)." | 1.30 | Vasopressin combined with nitroglycerin increases endocardial perfusion during cardiopulmonary resuscitation in pigs. ( Lindner, KH; Lurie, KG; Mayer, H; Prengel, AW; Wenzel, V, 1998) |
| "Treatment with aspirin for 2 or 7 days had no effect on the constrictive responses at the injured site 1 month after injury or on those at the noninjured site at all times examined." | 1.29 | Inhibitory effects of aspirin on coronary hyperreactivity to autacoids after arterial balloon injury in miniature pigs. ( Ibayashi, S; Kuga, T; Ohara, Y; Shimokawa, H; Takeshita, A; Tomoike, H, 1995) |
| "The efficacy of a controlled-release topical dosage form of glyceryl trinitrate (Nitroglycerin Transdermal Therapeutic System, Nitroderm TTS, NTG-TTS) was studied in the experimental model of myocardial ischaemia in beagles." | 1.28 | Efficacy of the glyceryl trinitrate transdermal therapeutic system in a dog model of myocardial ischaemia. ( Inukai, T; Nakao, K; Yamamoto, S, 1989) |
| "Pulmonary hypertension was induced by an iv infusion of group B Streptococci." | 1.27 | Neither nitroglycerin nor nitroprusside selectively reduces sepsis-induced pulmonary hypertension in piglets. ( Komar, KJ; Meadow, WL; Rudinsky, BF; Strates, E, 1987) |
| "Nitroglycerin was not shown to have any beneficial effects with or without its relative hypotensive effect." | 1.26 | Acute coronary occlusion in the pig: effect of nitroglycerin on regional myocardial blood flow. ( Millard, RW; Most, AS; Williams, DO, 1978) |
| " When keeping the heart rate constant by means of a pace maker, carbocromen even at higher dosage caused a clear-cut improvement." | 1.26 | [The effect of carbocromen on the ST segment of the epicardial electrocardiogram in a model of intermitting myocardial ischemia (author's transl)]. ( Kunath, B; Nitz, RE; Scholtholt, J; Sirbulescu, R, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 39 (16.05) | 18.7374 |
| 1990's | 40 (16.46) | 18.2507 |
| 2000's | 51 (20.99) | 29.6817 |
| 2010's | 71 (29.22) | 24.3611 |
| 2020's | 42 (17.28) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, F | 1 |
| Huang, Y | 1 |
| Wei, G | 1 |
| Huang, Z | 1 |
| Shi, C | 1 |
| Lin, W | 1 |
| Liao, J | 1 |
| Lanza, M | 2 |
| Filippone, A | 2 |
| Ardizzone, A | 1 |
| Casili, G | 2 |
| Paterniti, I | 2 |
| Esposito, E | 2 |
| Campolo, M | 2 |
| Wen, Q | 2 |
| Wang, Y | 6 |
| Pan, Q | 5 |
| Tian, R | 2 |
| Zhang, D | 5 |
| Qin, G | 6 |
| Zhou, J | 6 |
| Chen, L | 8 |
| Chen, H | 1 |
| Tang, X | 1 |
| Li, J | 1 |
| Hu, B | 1 |
| Yang, W | 1 |
| Zhan, M | 1 |
| Ma, T | 1 |
| Xu, S | 1 |
| Vong, CT | 1 |
| Chen, Y | 1 |
| Chen, Z | 1 |
| Gao, C | 1 |
| Yang, F | 2 |
| Wang, S | 1 |
| Ernstsen, C | 4 |
| Christensen, SL | 4 |
| Rasmussen, RH | 1 |
| Nielsen, BS | 1 |
| Jansen-Olesen, I | 5 |
| Olesen, J | 9 |
| Kristensen, DM | 4 |
| Zhang, Y | 4 |
| Giuffrè, L | 1 |
| Scuderi, SA | 1 |
| Cuzzocrea, S | 1 |
| Bertels, Z | 5 |
| Mangutov, E | 2 |
| Conway, C | 2 |
| Siegersma, K | 4 |
| Asif, S | 2 |
| Shah, P | 2 |
| Huck, N | 1 |
| Tawfik, VL | 1 |
| Pradhan, AA | 8 |
| Greco, R | 21 |
| Demartini, C | 12 |
| Zanaboni, AM | 9 |
| Francavilla, M | 5 |
| Reggiani, A | 2 |
| Realini, N | 1 |
| Scarpelli, R | 1 |
| Piomelli, D | 3 |
| Tassorelli, C | 22 |
| Wu, S | 1 |
| Ren, X | 1 |
| Zhu, C | 1 |
| Wang, W | 3 |
| Zhang, K | 1 |
| Li, Z | 1 |
| Liu, X | 1 |
| Foudah, AI | 3 |
| Devi, S | 3 |
| Alqarni, MH | 3 |
| Alam, A | 3 |
| Salkini, MA | 3 |
| Kumar, M | 3 |
| Almalki, HS | 3 |
| Guo, S | 2 |
| Hay-Schmidt, A | 4 |
| Ashina, M | 3 |
| Wang, Z | 2 |
| Lin, Q | 1 |
| Peng, YB | 1 |
| Sodergren, MH | 1 |
| Facchetti, S | 2 |
| Pacchetti, B | 1 |
| Palmisani, M | 2 |
| Franco, V | 2 |
| Barbosa, IR | 1 |
| Cunha, G | 1 |
| Luft, C | 1 |
| Rübensam, G | 1 |
| Freitas, RDS | 1 |
| Greggio, S | 1 |
| Venturin, G | 1 |
| Oliveira, JR | 1 |
| Costa, JC | 1 |
| Campos, MM | 1 |
| Jing, F | 2 |
| Zou, Q | 1 |
| Pu, Y | 1 |
| Xie, W | 2 |
| Li, R | 2 |
| Tang, W | 1 |
| Ma, Z | 1 |
| Miao, S | 1 |
| Li, C | 2 |
| Yang, C | 1 |
| Li, B | 1 |
| Wang, T | 1 |
| Gong, Z | 1 |
| Zhou, Y | 1 |
| Yu, S | 1 |
| Lai, T | 1 |
| Chen, X | 2 |
| He, J | 1 |
| Lv, P | 1 |
| Ge, H | 1 |
| Nilsson, KF | 1 |
| Gozdzik, W | 1 |
| Zielinski, S | 1 |
| Ratajczak, K | 1 |
| Göranson, SP | 1 |
| Rodziewicz, S | 1 |
| Harbut, P | 1 |
| Barteczko-Grajek, B | 1 |
| Albert, J | 1 |
| Frostell, C | 1 |
| Tumelero, E | 1 |
| Misto, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Peripheral Gene Expression of Endocannabinoid System Components in Episodic and Chronic Migraine Patients: a Pilot Study[NCT04324710] | 75 participants (Actual) | Observational | 2017-12-12 | Completed | |||
| Neurophysiological, Biomolecular and Psychological Aspects of Erenumab Treatment in Chronic Migraine: an Open Label, Hypothesis Generator Study[NCT04361721] | 40 participants (Anticipated) | Observational | 2020-01-15 | Recruiting | |||
| A Multidisciplinary Approach to the Identification of BIOmarkers of MIGraine: a Proof of Concept Study Based on the Stratification of Responders to CGRP Monoclonal Antibodies[NCT04503083] | 219 participants (Anticipated) | Observational | 2021-01-15 | Recruiting | |||
| Habituation of the Nociceptive Blink Reflex in Experimentally Induced Migraine Attack: a Cross-over, Randomized Controlled Study[NCT05718310] | 22 participants (Anticipated) | Interventional | 2022-11-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for nitroglycerin and Disease Models, Animal
| Article | Year |
|---|---|
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.
Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents | 2019 |
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.
Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents | 2019 |
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.
Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents | 2019 |
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.
Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents | 2019 |
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.
Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents | 2019 |
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.
Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents | 2019 |
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.
Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents | 2019 |
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.
Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents | 2019 |
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.
Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents | 2019 |
Pearls and pitfalls in human pharmacological models of migraine: 30 years' experience.
Topics: Animals; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation; Histamine; Human Experim | 2013 |
[Progression of the mechanism study on experimental migraine treated with acupuncture in rat model].
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Disease Models, Animal; Humans; Migraine Disorders | 2016 |
The oxidative stress concept of nitrate tolerance and the antioxidant properties of hydralazine.
Topics: Animals; Clinical Trials as Topic; Coronary Angiography; Disease Models, Animal; Dose-Response Relat | 2005 |
Nitrates in myocardial infarction.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Tolera | 1994 |
Cyclosporin A and transplant coronary disease after heart transplantation: facts and fiction.
Topics: Animals; Aorta; Coronary Disease; Coronary Vessels; Cyclosporine; Disease Models, Animal; Follow-Up | 1994 |
Experimental models for the study of cluster headache.
Topics: Animals; Cats; Cluster Headache; Disease Models, Animal; Humans; Nitroglycerin; Rats; Vasodilator Ag | 1999 |
Nitric oxide-induced neuronal activation in the central nervous system as an animal model of migraine: mechanisms and mediators.
Topics: Animals; Brain; Disease Models, Animal; Humans; Migraine Disorders; Neurons; Nitric Oxide; Nitroglyc | 2001 |
Myocardial ischemia (third of three parts).
Topics: Acute Disease; Animals; Assisted Circulation; Coronary Disease; Disease Models, Animal; Dogs; Glucoc | 1977 |
Experimental induction of spasm, sudden progression of organic stenosis and intramural hemorrhage in the epicardial coronary arteries.
Topics: Angina Pectoris, Variant; Animals; Coronary Disease; Coronary Vasospasm; Coronary Vessels; Disease M | 1991 |
The activity of molsidomine in experimental models of ischemic cardiac disease.
Topics: Animals; Coronary Circulation; Coronary Disease; Disease Models, Animal; Dogs; Electric Stimulation; | 1985 |
4 trials available for nitroglycerin and Disease Models, Animal
| Article | Year |
|---|---|
Central components of the analgesic/antihyperalgesic effect of nimesulide: studies in animal models of pain and hyperalgesia.
Topics: Analgesia; Animals; Brain; Disease Models, Animal; Gene Expression; Genes, fos; Hyperalgesia; Male; | 2003 |
Nitrates in myocardial infarction.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Tolera | 1994 |
Prevention of nitrate tolerance with concomitant administration of hydralazine.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolera | 1996 |
High-dose intravascular beta-radiation after de novo stent implantation induces coronary artery spasm.
Topics: Animals; Beta Particles; Blood Vessel Prosthesis Implantation; Brachytherapy; Catheterization; Coron | 2002 |
229 other studies available for nitroglycerin and Disease Models, Animal
| Article | Year |
|---|---|
Exogenous Hsp70 attenuates nitroglycerin-induced migraine-like symptoms in mice.
Topics: Adult; Animals; Disease Models, Animal; Female; HSP70 Heat-Shock Proteins; Humans; Male; Mice; Mice, | 2021 |
SCFA Treatment Alleviates Pathological Signs of Migraine and Related Intestinal Alterations in a Mouse Model of NTG-Induced Migraine.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Down-Regulation; Fatty Acids, | 2021 |
MicroRNA-155-5p promotes neuroinflammation and central sensitization via inhibiting SIRT1 in a nitroglycerin-induced chronic migraine mouse model.
Topics: Animals; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Migraine Disorders; Neur | 2021 |
IL-17 crosses the blood-brain barrier to trigger neuroinflammation: a novel mechanism in nitroglycerin-induced chronic migraine.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Humans; Interleukin-17; Migraine Disorders; Ne | 2022 |
Classical prescription Dachuanxiong Formula delays nitroglycerin-induced pain response in migraine mice through reducing endothelin-1 level and regulating fatty acid biosynthesis.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelin | 2022 |
The PACAP pathway is independent of CGRP in mouse models of migraine: possible new drug target?
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Mice; Migraine Disorders; Nitrogly | 2022 |
Sphingosine-1 phosphate receptor 1 contributes to central sensitization in recurrent nitroglycerin-induced chronic migraine model.
Topics: Animals; Central Nervous System Sensitization; Disease Models, Animal; Hyperalgesia; Mice; Migraine | 2022 |
Supplementation with SCFAs Re-Establishes Microbiota Composition and Attenuates Hyperalgesia and Pain in a Mouse Model of NTG-Induced Migraine.
Topics: Animals; Butyric Acid; Dietary Supplements; Disease Models, Animal; Fatty Acids, Volatile; Gastroint | 2022 |
Migraine and peripheral pain models show differential alterations in neuronal complexity.
Topics: Animals; Complex Regional Pain Syndromes; Cortical Spreading Depression; Disease Models, Animal; Hea | 2022 |
Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine.
Topics: Amides; Amidohydrolases; Animals; Disease Models, Animal; Endocannabinoids; Hyperalgesia; Inflammati | 2022 |
Modelling migraine-related features in the nitroglycerin animal model: Trigeminal hyperalgesia is associated with affective status and motor behavior.
Topics: Animals; Disease Models, Animal; Formaldehyde; Hyperalgesia; Male; Migraine Disorders; Nitroglycerin | 2022 |
A c-Fos activation map in nitroglycerin/levcromakalim-induced models of migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Crom | 2022 |
Antagonism of CGRP Receptor: Central and Peripheral Mechanisms and Mediators in an Animal Model of Chronic Migraine.
Topics: Animals; Ankyrins; Calcitonin; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Rece | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
PACAP signaling is not involved in GTN- and levcromakalim-induced hypersensitivity in mouse models of migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cromakalim; Disease Models, Animal; Drug Hypersensitivity; | 2022 |
PACAP signaling is not involved in GTN- and levcromakalim-induced hypersensitivity in mouse models of migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cromakalim; Disease Models, Animal; Drug Hypersensitivity; | 2022 |
PACAP signaling is not involved in GTN- and levcromakalim-induced hypersensitivity in mouse models of migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cromakalim; Disease Models, Animal; Drug Hypersensitivity; | 2022 |
PACAP signaling is not involved in GTN- and levcromakalim-induced hypersensitivity in mouse models of migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cromakalim; Disease Models, Animal; Drug Hypersensitivity; | 2022 |
Multi-region local field potential signatures and brain coherence alternations in response to nitroglycerin-induced migraine attacks.
Topics: Animals; Brain; Disease Models, Animal; Hyperalgesia; Migraine Disorders; Nitroglycerin; Rats | 2023 |
Characterization of the biochemical and behavioral effects of cannabidiol: implications for migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cannabidiol; Disease Models, Animal; Hyperalgesia; Male; M | 2023 |
Fructose supplementation shifts rat brain metabolism in experimental migraine.
Topics: Animals; Brain; Dietary Supplements; Disease Models, Animal; Fructose; Glucose; Male; Migraine Disor | 2023 |
Activity of FAAH-Inhibitor JZP327A in an Experimental Rat Model of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Endocannabinoids; Hyperalgesia; Ma | 2023 |
GLP-1R agonist liraglutide attenuates pain hypersensitivity by stimulating IL-10 release in a nitroglycerin-induced chronic migraine mouse model.
Topics: Animals; Disease Models, Animal; Glucagon-Like Peptide-1 Receptor; Hyperalgesia; Interleukin-10; Lir | 2023 |
Proteomics profiling reveals mitochondrial damage in the thalamus in a mouse model of chronic migraine.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Mice; Migraine Disorders; Nitroglycerin; Pr | 2023 |
Rhynchophylline attenuates migraine in trigeminal nucleus caudalis in nitroglycerin-induced rat model by inhibiting MAPK/NF-кB signaling.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Male; MAP Kinase Signalin | 2019 |
Pulmonary Vasodilation by Intravenous Infusion of Organic Mononitrites Of 1,2-Propanediol in Acute Pulmonary Hypertension Induced by Aortic Cross Clamping and Reperfusion: A Comparison With Nitroglycerin in Anesthetized Pigs.
Topics: Animals; Disease Models, Animal; Female; Hypertension, Pulmonary; Infusions, Intravenous; Male; Nitr | 2020 |
FAAH inhibition as a preventive treatment for migraine: A pre-clinical study.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Disease Models, Animal; Male; Migraine Disorders; | 2020 |
Altered activity in the nucleus raphe magnus underlies cortical hyperexcitability and facilitates trigeminal nociception in a rat model of medication overuse headache.
Topics: Acetaminophen; Action Potentials; Animals; Cerebral Cortex; Disease Models, Animal; Headache Disorde | 2019 |
PD-L1 and PD-1 expressed in trigeminal ganglia may inhibit pain in an acute migraine model.
Topics: Acute Disease; Animals; B7-H1 Antigen; Disease Models, Animal; Gene Expression; Male; Mice; Mice, In | 2020 |
Thymoquinone Inhibits Neurogenic Inflammation Underlying Migraine Through Modulation of Calcitonin Gene-Related Peptide Release and Stabilization of Meningeal Mast Cells in Glyceryltrinitrate-Induced Migraine Model in Rats.
Topics: Animals; Anti-Inflammatory Agents; Benzoquinones; Calcitonin Gene-Related Peptide; Disease Models, A | 2020 |
A causal role for TRESK loss of function in migraine mechanisms.
Topics: Animals; CRISPR-Cas Systems; Disease Models, Animal; Humans; Induced Pluripotent Stem Cells; Loss of | 2019 |
Tibetan medicine Ru-yi-Zhen-bao Pills exhibits anti-migraine effect through mediating PAG anti-nociceptive channel.
Topics: Animals; Calcitonin Gene-Related Peptide; Cholecystokinin; Disease Models, Animal; Drugs, Chinese He | 2020 |
Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model.
Topics: Adenosine Triphosphate; Animals; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Related Peptide; | 2020 |
The effects of nitroglycerin in the zone of stasis in a rat burn model.
Topics: Animals; Burns; Disease Models, Animal; Edema; Inflammation; Male; Nitroglycerin; Rats; Silver Sulfa | 2020 |
No central action of CGRP antagonising drugs in the GTN mouse model of migraine.
Topics: Animals; Antibodies, Monoclonal; Calcitonin Gene-Related Peptide Receptor Antagonists; Disease Model | 2020 |
A Pre-Existing Myogenic Temporomandibular Disorder Increases Trigeminal Calcitonin Gene-Related Peptide and Enhances Nitroglycerin-Induced Hypersensitivity in Mice.
Topics: Animals; Biomarkers; Calcitonin Gene-Related Peptide; Disease Models, Animal; Disease Susceptibility | 2020 |
Physical exercise enhances vulnerability to migraine headache associated with CGRP up-expression in trigeminal nucleus caudalis of stressed rats.
Topics: Animals; Calcitonin; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Hyperalgesia; | 2020 |
Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Benzamides; Cortical Spreading Depression; Disease Models, Animal; GABA | 2020 |
α6GABA
Topics: Animals; Disease Models, Animal; Fluorescent Antibody Technique; GABA Plasma Membrane Transport Prot | 2021 |
Double-Binding Botulinum Molecule with Reduced Muscle Paralysis: Evaluation in In Vitro and In Vivo Models of Migraine.
Topics: Analgesics; Animals; Botulinum Toxins; Cell Line, Tumor; Disease Models, Animal; Electromyography; H | 2021 |
A non-convulsant delta-opioid receptor agonist, KNT-127, reduces cortical spreading depression and nitroglycerin-induced allodynia.
Topics: Analgesics, Opioid; Animals; Cortical Spreading Depression; Disease Models, Animal; Female; Hyperalg | 2021 |
P2X7R-mediated autophagic impairment contributes to central sensitization in a chronic migraine model with recurrent nitroglycerin stimulation in mice.
Topics: Animals; Autophagy; Central Nervous System Sensitization; Chronic Disease; Disease Models, Animal; M | 2021 |
Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition.
Topics: Acetylation; Animals; Behavior, Animal; Brain; Calcitonin Gene-Related Peptide Receptor Antagonists; | 2021 |
Quantifying the Effect of Topical Nitroglycerin on Random Pattern Flap Perfusion in a Rodent Model: An Application of the ViOptix Intra.Ox for Dynamic Flap Perfusion Assessment and Salvage.
Topics: Animals; Disease Models, Animal; Graft Survival; Humans; Necrosis; Nitroglycerin; Oxygen; Postoperat | 2021 |
Protein kinase Cδ as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice.
Topics: Animals; Disease Models, Animal; Headache; Hyperalgesia; Mice; Migraine Disorders; Nitroglycerin; Pr | 2021 |
Pulmonary Microcirculation during Experimental Pulmonary Thromboembolism under Conditions of Activation and Blockade of Muscarinic Acetylcholine Receptors.
Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Disease Models, Animal; Lung; Microcirculation; Mu | 2021 |
Involvement of P2Y
Topics: Animals; Disease Models, Animal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Migraine Disorders; N | 2021 |
Analgesia effect of baicalein against NTG-induced migraine in rats.
Topics: Analgesia; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Endothelins; Flavanones | 2017 |
Inflammation-induced fetal growth restriction in rats is associated with increased placental HIF-1α accumulation.
Topics: Animals; Disease Models, Animal; Female; Fetal Growth Retardation; Gene Expression Regulation; Gesta | 2017 |
Nitroglycerin challenge induces lateralized headache in nasociliarynerve-ligated rats: implications for chronic migraine.
Topics: Animals; Brain Chemistry; Disease Models, Animal; Male; Maze Learning; Migraine Disorders; Nitroglyc | 2017 |
Effect of Topical Iloprost and Nitroglycerin on Gastric Microcirculation and Barrier Function during Hemorrhagic Shock in Dogs.
Topics: Administration, Topical; Animals; Disease Models, Animal; Dogs; Female; Gastric Absorption; Gastric | 2017 |
The effects of repeated nitroglycerin administrations in rats; modeling migraine-related endpoints and chronification.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Endpoint Determination; Hyperalgesia; | 2017 |
Animal Model of Chronic Migraine-Associated Pain.
Topics: Animals; Association Learning; Chronic Pain; Disease Models, Animal; Female; Hyperalgesia; Mice; Mic | 2017 |
The role of the transient receptor potential ankyrin type-1 (TRPA1) channel in migraine pain: evaluation in an animal model.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Hyperalgesia; Male; Migraine Disor | 2017 |
Soluble guanylyl cyclase is a critical regulator of migraine-associated pain.
Topics: Adrenergic beta-Antagonists; Allosteric Regulation; Animals; Anticonvulsants; Calcitonin Gene-Relate | 2018 |
Metabolomics Strategy Using High Resolution Mass Spectrometry Reveals Novel Biomarkers and Pain-Relief Effect of Traditional Chinese Medicine Prescription Wu-Zhu-Yu Decoction Acting on Headache Modelling Rats.
Topics: Animals; Biomarkers; Chromatography, Liquid; Discriminant Analysis; Disease Models, Animal; Drugs, C | 2017 |
AMPA receptor GluA1 Ser831 phosphorylation is critical for nitroglycerin-induced migraine-like pain.
Topics: Animals; Avoidance Learning; Calcium; Cells, Cultured; Disease Models, Animal; Hyperalgesia; Locomot | 2018 |
The GTN patch: a simple and effective new approach to cardioprotection?
Topics: Administration, Cutaneous; Animals; Blood Pressure; Disease Models, Animal; Male; Mice, Inbred C57BL | 2018 |
Cerebrolysin attenuates hyperalgesia, photophobia, and neuroinflammation in a nitroglycerin-induced migraine model in rats.
Topics: Amino Acids; Animals; Central Nervous System Agents; Disease Models, Animal; Grooming; Hyperalgesia; | 2018 |
The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats.
Topics: Administration, Intravenous; Animals; Curcumin; Disease Models, Animal; Liposomes; Male; Malondialde | 2018 |
Dynamic sodium imaging at ultra-high field reveals progression in a preclinical migraine model.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Disease Progression; Dose-Response Relationsh | 2018 |
Chronic and intermittent administration of systemic nitroglycerin in the rat induces an increase in the gene expression of CGRP in central areas: potential contribution to pain processing.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Fructose; Gene Expression; Male; M | 2018 |
Nitroglycerin application and coronary arteriogenesis.
Topics: Animals; Aorta, Thoracic; Aspirin; Coronary Occlusion; Coronary Vessels; Disease Models, Animal; Hum | 2018 |
Nitroglycerine limits infarct size through S-nitrosation of cyclophilin D: a novel mechanism for an old drug.
Topics: Adult; Aged; Animals; Cyclophilins; Disease Models, Animal; Enzyme Inhibitors; Female; Humans; Male; | 2019 |
Microglia P2X4 receptor contributes to central sensitization following recurrent nitroglycerin stimulation.
Topics: Animals; Benzodiazepinones; Calcitonin Gene-Related Peptide; Calcium-Binding Proteins; Disease Model | 2018 |
Augmentation of the Enhanced Permeability and Retention Effect with Nitric Oxide-Generating Agents Improves the Therapeutic Effects of Nanomedicines.
Topics: Animals; Antineoplastic Agents; Arginine; Disease Models, Animal; Doxorubicin; Female; Hydroxyurea; | 2018 |
Delta opioid receptor agonists are effective for multiple types of headache disorders.
Topics: Animals; Benzamides; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Headache Diso | 2019 |
Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium-Binding Proteins; Central Nervous System Sensitiza | 2019 |
An epicardial delivery of nitroglycerine by active hydraulic ventricular support drug delivery system improves cardiac function in a rat model.
Topics: Administration, Intravenous; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2020 |
Preliminary investigation of topical nitroglycerin formulations containing natural wound healing agent in diabetes-induced foot ulcer.
Topics: Administration, Topical; Animals; Diabetic Foot; Disease Models, Animal; Female; Gels; Male; Nitrogl | 2015 |
Nitric oxide synthase, calcitonin gene-related peptide and NK-1 receptor mechanisms are involved in GTN-induced neuronal activation.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipe | 2014 |
Changes in calcitonin gene-related peptide (CGRP) receptor component and nitric oxide receptor (sGC) immunoreactivity in rat trigeminal ganglion following glyceroltrinitrate pretreatment.
Topics: Animals; Disease Models, Animal; Fluorescent Antibody Technique; Guanylate Cyclase; Immunohistochemi | 2013 |
Characterization of a novel model of chronic migraine.
Topics: Animals; Chronic Disease; Disease Models, Animal; Female; Freund's Adjuvant; Hyperalgesia; Male; Mic | 2014 |
Aldehyde dehydrogenase 2 partly mediates hypotensive effect of nitrite on L-NAME-induced hypertension in normoxic rat.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Antihypertensive Agents; Blo | 2014 |
Effects of CGRP receptor antagonism in nitroglycerin-induced hyperalgesia.
Topics: Animals; Calcitonin Gene-Related Peptide Receptor Antagonists; Disease Models, Animal; Hyperalgesia; | 2014 |
M-atrial natriuretic peptide and nitroglycerin in a canine model of experimental acute hypertensive heart failure: differential actions of 2 cGMP activating therapeutics.
Topics: Aldosterone; Angiotensin II; Animals; Arterial Pressure; Atrial Natriuretic Factor; Cardiac Pacing, | 2014 |
Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine.
Topics: Animals; Brain; Central Nervous System Sensitization; Disease Models, Animal; Evoked Potentials, Aud | 2014 |
Increasing the tolerance of DCD hearts to warm ischemia by pharmacological postconditioning.
Topics: Animals; Death; Disease Models, Animal; Edema; Erythropoietin; Guanidines; Heart; Heart Failure; Hea | 2014 |
Investigating the cardio-protective abilities of supplemental L-arginine on parameters of endothelial function in a hypercholesterolemic animal model.
Topics: Amidohydrolases; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Cardiotonic Agents; Ca | 2014 |
Pregabalin alleviates the nitroglycerin-induced hyperalgesia in rats.
Topics: Analgesics; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; | 2015 |
Improvement of hepatocyte transplantation efficiency in the mdr2-/- mouse model by glyceryl trinitrate.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; | 2015 |
Riboflavin and vitamin E increase brain calcium and antioxidants, and microsomal calcium-ATP-ase values in rat headache models induced by glyceryl trinitrate.
Topics: Animals; Antioxidants; Ascorbic Acid; beta Carotene; Brain; Calcium; Calcium-Transporting ATPases; D | 2015 |
Protective effects of riboflavin and selenium on brain microsomal Ca2+-ATPase and oxidative damage caused by glyceryl trinitrate in a rat headache model.
Topics: Animals; Brain; Calcium-Transporting ATPases; Disease Models, Animal; Female; Headache; Microsomes; | 2015 |
PEGylated exendin-4, a modified GLP-1 analog exhibits more potent cardioprotection than its unmodified parent molecule on a dose to dose basis in a murine model of myocardial infarction.
Topics: Aminophylline; Animals; Atropine; Blotting, Western; Cardiovascular Agents; Disease Models, Animal; | 2015 |
Effects of peripheral FAAH blockade on NTG-induced hyperalgesia--evaluation of URB937 in an animal model of migraine.
Topics: Amidohydrolases; Analgesics; Animals; Cannabinoids; Disease Models, Animal; Dose-Response Relationsh | 2015 |
Effects of nitric oxide-related compounds in the acute ketamine animal model of schizophrenia.
Topics: Acute Disease; Animals; Antipsychotic Agents; Cognition Disorders; Dietary Sucrose; Disease Models, | 2015 |
Role of phosphorylated extracellular signal-regulated kinase, calcitonin gene-related peptide and cyclooxygenase-2 in experimental rat models of migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Mod | 2015 |
Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonist | 2015 |
Evaluation of ADMA-DDAH-NOS axis in specific brain areas following nitroglycerin administration: study in an animal model of migraine.
Topics: Amidohydrolases; Animals; Arginine; Brain; Disease Models, Animal; Drug Evaluation, Preclinical; Mal | 2015 |
Epoetin beta pegol prevents endothelial dysfunction as evaluated by flow-mediated dilation in chronic kidney disease rats.
Topics: Animals; Blood Pressure; Body Weight; Creatinine; Disease Models, Animal; Endothelium, Vascular; Ery | 2015 |
The modulatory effect of anandamide on nitroglycerin-induced sensitization in the trigeminal system of the rat.
Topics: Afferent Pathways; Animals; Arachidonic Acids; Blotting, Western; Cannabinoid Receptor Agonists; Cen | 2016 |
The effects of acute and preventive migraine therapies in a mouse model of chronic migraine.
Topics: Acute Disease; Amiloride; Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclin | 2016 |
Mechanisms mediating nitroglycerin-induced delayed-onset hyperalgesia in the rat.
Topics: Animals; Disease Models, Animal; Endothelial Cells; Female; Hyperalgesia; Male; Mast Cells; Neutroph | 2016 |
Tumor-Targeting Salmonella typhimurium A1-R: An Overview.
Topics: Amino Acids; Animals; Disease Models, Animal; Humans; Mice; Neoplasms; Nitric Oxide; Nitroglycerin; | 2016 |
Enhancement of Tumor-Targeted Delivery of Bacteria with Nitroglycerin Involving Augmentation of the EPR Effect.
Topics: Animals; Antineoplastic Agents; Bacteria; Disease Models, Animal; Drug Delivery Systems; Humans; Mac | 2016 |
Clinically relevant behavioral endpoints in a recurrent nitroglycerin migraine model in rats.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Male; Migraine Disorders; Motor Activity; Nitrogl | 2016 |
Valproate ameliorates nitroglycerin-induced migraine in trigeminal nucleus caudalis in rats through inhibition of NF-кB.
Topics: Animals; Blotting, Western; Calcitonin Gene-Related Peptide; Disease Models, Animal; Down-Regulation | 2016 |
RNA Sequencing of Trigeminal Ganglia in Rattus Norvegicus after Glyceryl Trinitrate Infusion with Relevance to Migraine.
Topics: Animals; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Infusions, I | 2016 |
Atorvastatin Combined Nitroglycerin Therapy Confer Additive Effects on Rabbits with Dyslipidemia.
Topics: Animals; Atorvastatin; Disease Models, Animal; Drug Therapy, Combination; Dyslipidemias; Hydroxymeth | 2016 |
Nitroglycerin induces DNA damage and vascular cell death in the setting of nitrate tolerance.
Topics: Animals; Blotting, Western; Comet Assay; Disease Models, Animal; DNA Damage; Drug Tolerance; Endothe | 2016 |
Ghrelin attenuates hyperalgesia and light aversion-induced by nitroglycerin in male rats.
Topics: Animals; Anxiety; Disease Models, Animal; Ghrelin; Hyperalgesia; Male; Migraine Disorders; Nitroglyc | 2016 |
Pharmacology of reflex blinks in the rat: a novel model for headache research.
Topics: Animals; Blinking; Disease Models, Animal; Electromyography; Male; Migraine Disorders; Nitric Oxide | 2016 |
Pharmacodynamic action and mechanism of Du Liang soft capsule, a traditional Chinese medicine capsule, on treating nitroglycerin-induced migraine.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Behavior, Animal; Biomarkers; Brain Stem; C | 2017 |
Implantation of paclitaxel-eluting stent impairs the vascular compliance of arteries in porcine coronary stenting model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Coronary Restenosis; Coronary Stenosis; Coronary Vessels | 2009 |
[The study of vasodilative and antiischemic function of nicorandil in regional ischemia and reperfusion of rat heart in vivo].
Topics: Animals; Blood Pressure; Disease Models, Animal; Drug Therapy, Combination; Heart Rate; Male; Myocar | 2008 |
Delayed anti-arrhythmic effect of nitroglycerin in anesthetized rats: involvement of CGRP, PKC and mK ATP channels.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzophenanthridines; Calcitonin | 2009 |
Differential effects of corticosteroids on the expression of cyclooxygenase-2, tumour necrosis factor-alpha and matrix metalloproteinase-9 in an animal model of migraine.
Topics: Animals; Blotting, Western; Cyclooxygenase 2; Disease Models, Animal; Fluorescent Antibody Technique | 2008 |
[Relationship between P-type Na+ -K+ -Atpase and migraine: an experimental study with rats].
Topics: Animals; Blotting, Western; Disease Models, Animal; Female; Male; Migraine Disorders; Nitroglycerin; | 2008 |
Selective inhibition of cyclooxygenase-2 attenuates nitroglycerin-induced calmodulin-dependent protein kinase II alpha in rat trigeminal nucleus caudalis.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebral Arteries; Cerebrovascular Circ | 2009 |
Different effects of ascorbate deprivation and classical vascular nitrate tolerance on aldehyde dehydrogenase-catalysed bioactivation of nitroglycerin.
Topics: Aldehyde Dehydrogenase; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Biotransformation; Chloral | 2009 |
Effects of 1400W and/or nitroglycerin on renal oxygenation and kidney function during endotoxaemia in anaesthetized rats.
Topics: Acute Kidney Injury; Amidines; Anesthesia, General; Animals; Benzylamines; Biomarkers; Creatinine; D | 2009 |
[The study of endothelial dysfunction in animals with experimentally induced deficiency of sex hormones].
Topics: Acetylcholine; Animals; Arginine; Disease Models, Animal; Endothelium, Vascular; Female; Gonadal Ste | 2009 |
Alterations of the endocannabinoid system in an animal model of migraine: evaluation in cerebral areas of rat.
Topics: Amidohydrolases; Animals; Brain; Cannabinoid Receptor Modulators; Disease Models, Animal; Endocannab | 2010 |
Atorvastatin attenuates NF-kappaB activation in trigeminal nucleus caudalis in a rat model of migraine.
Topics: Analysis of Variance; Animals; Atorvastatin; Blotting, Western; Cell Nucleus; Disease Models, Animal | 2009 |
Cardiovascular images. A novel real-time fluorescent optical imaging system in mouse heart: a powerful tool for studying coronary circulation and cardiac function.
Topics: Animals; Coronary Circulation; Disease Models, Animal; Fluorescein Angiography; Fluorescent Dyes; In | 2009 |
Nimodipine prevents memory impairment caused by nitroglycerin-induced hypotension in adult mice.
Topics: Animals; Avoidance Learning; Behavior, Animal; Blood Pressure; Calcium Channel Blockers; Cerebrovasc | 2009 |
Nitroglycerin-induced preconditioning: interaction with nitrate tolerance.
Topics: Animals; Antioxidants; Ascorbic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2010 |
Effects of anandamide in migraine: data from an animal model.
Topics: Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Modulators; Disease M | 2011 |
Evaluation of anti-migraine potential of Areca catechu to prevent nitroglycerin-induced delayed inflammation in rat meninges: possible involvement of NOS inhibition.
Topics: Animals; Anti-Inflammatory Agents; Areca; Blood Proteins; Disease Models, Animal; Dura Mater; Enzyme | 2011 |
Continuous intrathecal glyceryl trinitrate prevents delayed cerebral vasospasm in the single-SAH rabbit model in vivo.
Topics: Animals; Disease Models, Animal; Injections, Spinal; Intracranial Aneurysm; Male; Nitroglycerin; Rab | 2011 |
A naturalistic glyceryl trinitrate infusion migraine model in the rat.
Topics: Anesthesia; Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Human | 2012 |
[Resveratrol improves coronary collateral circulation in pigs with experimental acute coronary occlusion].
Topics: Animals; Antioxidants; Collateral Circulation; Coronary Circulation; Coronary Occlusion; Coronary Ve | 2011 |
Towards a reliable animal model of migraine.
Topics: Animals; Disease Models, Animal; Drug Design; Humans; Migraine Disorders; Nitroglycerin; Reproducibi | 2012 |
Supplementation of nitric oxide attenuates AβPP and BACE1 protein in cerebral microcirculation of eNOS-deficient mice.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopep | 2013 |
Effect of sex and estrogens on neuronal activation in an animal model of migraine.
Topics: Analysis of Variance; Animals; Brain; Contraceptive Agents; Disease Models, Animal; Estradiol; Femal | 2013 |
Vasopressin with delayed combination of nitroglycerin increases survival rate in asphyxia rat model.
Topics: Animals; Asphyxia; Cardiopulmonary Resuscitation; Coronary Circulation; Disease Models, Animal; Drug | 2002 |
Adverse effects of nitroglycerin treatment on endothelial function, vascular nitrotyrosine levels and cGMP-dependent protein kinase activity in hyperlipidemic Watanabe rabbits.
Topics: Animals; Antioxidants; beta Carotene; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; | 2002 |
Inhaled nitric oxide modifies left ventricular diastolic stress in the presence of vasoactive agents in heart failure.
Topics: Acetylcholine; Administration, Inhalation; Angiotensin II; Animals; Diastole; Disease Models, Animal | 2003 |
Exaggerated cardiovascular effects of cocaine in conscious dogs with pacing-induced dilated cardiomyopathy.
Topics: Adrenergic beta-Agonists; Animals; Baroreflex; Biomarkers; Cardiac Pacing, Artificial; Cardiomyopath | 2002 |
Relaxant properties mediated by nitroglycerin in aortic coarctation hypertensive rats.
Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Coarctation; Blood Pressure; Charybdotoxin; Disea | 2002 |
Cardiorenal and humoral properties of a novel direct soluble guanylate cyclase stimulator BAY 41-2272 in experimental congestive heart failure.
Topics: Aldosterone; Angiotensin II; Animals; Cardiac Output; Cardiac Pacing, Artificial; Disease Models, An | 2003 |
Effect of nitric oxide donor nitroglycerin on bone mineral density in a rat model of estrogen deficiency-induced osteopenia.
Topics: Animals; Bone Density; Bone Diseases, Metabolic; Disease Models, Animal; Estrogens; Female; Nitric O | 2003 |
Analysis of responses to valerian root extract in the feline pulmonary vascular bed.
Topics: Acetylcholine; Animals; Arachidonic Acid; Bradykinin; Calcium Channel Agonists; Cats; Disease Models | 2003 |
Nitroglycerin enhances cGMP expression in specific neuronal and cerebrovascular structures of the rat brain.
Topics: Animals; Arterioles; Brain; Cerebrovascular Circulation; Cyclic GMP; Disease Models, Animal; Immunoh | 2004 |
[Changes in tissue plasminogen activator and plasminogen activator inhibitor during administration of nitroglycerine into internal thoracic artery in dogs with acute myocardial ischemia].
Topics: Animals; Disease Models, Animal; Dogs; Female; Infusion Pumps; Male; Myocardial Ischemia; Nitroglyce | 2004 |
Dynamic infrared imaging for the detection of malignancy.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Humans; Image Processing, Compu | 2004 |
Measuring transient systemic conductance and capacitance responses using a modified Brooksby-Donald technique in anesthetized, autonomically intact rabbits.
Topics: Analysis of Variance; Animals; Blood Flow Velocity; Disease Models, Animal; Female; Injections, Intr | 2004 |
Increased myocardial N-myristoyltransferase activity in rotenone model of Parkinsonism.
Topics: Acyl Coenzyme A; Aminophylline; Animals; Atropine; Disease Models, Animal; Drug Combinations; Humans | 2005 |
Activation of the transcription factor NF-kappaB in the nucleus trigeminalis caudalis in an animal model of migraine.
Topics: Animals; Blotting, Western; Disease Models, Animal; Immunohistochemistry; Male; Migraine Disorders; | 2005 |
Parthenolide is the component of tanacetum parthenium that inhibits nitroglycerin-induced Fos activation: studies in an animal model of migraine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Disease Models, Animal; Immunohistochemistr | 2005 |
Kynurenine in combination with probenecid mitigates the stimulation-induced increase of c-fos immunoreactivity of the rat caudal trigeminal nucleus in an experimental migraine model.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Genes, fos; Immunohistochemistry; Kynure | 2007 |
[The modulatory effect of estrogen on the caudal trigeminal nucleus of the rat in an animal model of migraine].
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calciu | 2006 |
Restoration of impaired endothelium-dependent coronary vasodilation in failing heart: role of eNOS phosphorylation and CGMP/cGK-I signaling.
Topics: Acetylcholine; Animals; Bradykinin; Coronary Circulation; Coronary Vessels; Cyclic GMP; Cyclic GMP-D | 2007 |
Prevention of electrical stimulation-induced increase of c-fos immunoreaction in the caudal trigeminal nucleus by kynurenine combined with probenecid.
Topics: Adjuvants, Pharmaceutic; Afferent Pathways; Analgesics; Animals; Blood-Brain Barrier; Disease Models | 2007 |
Involvement of alpha(2)-adrenoceptors in the gastric protective effect of nitroglycerin against acidified ethanol-induced mucosal injury.
Topics: Animals; Central Nervous System Depressants; Disease Models, Animal; Ethanol; Female; Gastric Mucosa | 2007 |
Intragastric nitroglycerin at a vasodilatory dose attenuates acidified aspirin-induced gastric mucosal injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Flow Velocity; Disease Models, Anim | 2007 |
Nitroglycerin induces late preconditioning against arrhythmias but not stunning in conscious sheep.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Consciousness; Coronary Circulation; Disease | 2007 |
Heme oxygenase-1: a novel key player in the development of tolerance in response to organic nitrates.
Topics: Aldehyde Dehydrogenase; Animals; Chromatography, High Pressure Liquid; Cyclic GMP; Disease Models, A | 2007 |
Vascular effects of long-term propranolol administration after chronic nitric oxide blockade.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Aorta; Biological Factors; Blood Pressure; Calcium; | 2007 |
Combating nitrate tolerance: a novel endogenous mechanism.
Topics: Animals; Coronary Stenosis; Disease Models, Animal; Drug Tolerance; Female; Humans; Male; Nitric Oxi | 2007 |
nNOS-dependent reactivity of cerebral arterioles in Type 1 diabetes.
Topics: Animals; Cerebral Arteries; Diabetes Mellitus, Type 1; Disease Models, Animal; Dose-Response Relatio | 2007 |
Illumination with blue light reactivates respiratory activity of mitochondria inhibited by nitric oxide, but not by glycerol trinitrate.
Topics: Animals; Cell Respiration; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Light; Male | 2008 |
Vascular tolerance to nitroglycerin in ascorbate deficiency.
Topics: Aldehyde Dehydrogenase; Animals; Aorta; Ascorbic Acid; Ascorbic Acid Deficiency; Disease Models, Ani | 2008 |
[Efficacy of different therapeutic principles in experimental retinal vessel occlusions].
Topics: Animals; Aspirin; Disease Models, Animal; Epoprostenol; Laser Therapy; Nitroglycerin; Rabbits; Retin | 1983 |
Experimental observations on peritoneal transport in rabbits.
Topics: Animals; Biological Transport; Creatinine; Disease Models, Animal; Dopamine; Fenoterol; Inulin; Isop | 1983 |
[Evaluation of the antianginal action of pharmacological substances by the change in the initiation threshold for myocardial ischemia in conscious rabbits].
Topics: Angina Pectoris; Animals; Coronary Circulation; Coronary Disease; Dipyridamole; Disease Models, Anim | 1984 |
Relative effects of nitroglycerin and nitroprusside during experimental acute myocardial ischemia.
Topics: Animals; Blood Pressure; Coronary Disease; Disease Models, Animal; Dogs; Electrocardiography; Ferric | 1980 |
Mechanism of action of nitroglycerin during exercise in a rat model of heart failure. Improvement of blood flow to the renal, splanchnic, and cutaneous beds.
Topics: Animals; Bronchial Arteries; Cardiac Output; Disease Models, Animal; Exercise Test; Heart; Heart Fai | 1981 |
Effect of an increased cardiac output on vascular responses to vasoactive agents in two-kidney, one-clip Goldblatt hypertension.
Topics: Acetylcholine; Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Dogs; Dose-Response | 1982 |
[Pharmacologic evaluation of electrical processes in the myocardium].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Drug Evaluation | 1982 |
Peripheral vascular effects of nitroglycerin in a conscious rat model of heart failure.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cardiac Output; Disease Models, Animal; Heart Failure; Hear | 1982 |
Low-dose i.v. acetylcholine acts as a "preconditioning-mimetic" in the canine model.
Topics: Acetylcholine; Animals; Disease Models, Animal; Dogs; Heart; Humans; Infusions, Intravenous; Myocard | 1995 |
Retinal artery occlusion in rabbit eyes using human atheroma.
Topics: Animals; Arteriosclerosis; Carotid Artery, Common; Catheterization, Peripheral; Cholesterol; Disease | 1995 |
Discordant effects of dietary L-arginine on vascular structure and reactivity in hypercholesterolemic rabbits.
Topics: Acetylcholine; Analysis of Variance; Animals; Aorta, Abdominal; Arginine; Cholesterol; Cholesterol, | 1995 |
Pulmonary edema induced by angiotensin II in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Disease Models, Animal; D | 1995 |
Beneficial effect of nitroglycerin on arterial rethrombosis after thrombolysis. Results from a rabbit thrombosis model.
Topics: Animals; Aspirin; Blood Flow Velocity; Blood Pressure; Disease Models, Animal; Drug Therapy, Combina | 1995 |
Inhibitory effects of aspirin on coronary hyperreactivity to autacoids after arterial balloon injury in miniature pigs.
Topics: Angiography; Angioplasty, Balloon, Coronary; Animals; Aspirin; Autacoids; Blood Pressure; Constricti | 1995 |
The effects of dobutamine, propranolol and nitroglycerin on an experimental canine model of congestive heart failure.
Topics: Analysis of Variance; Animals; Blood Pressure; Cardiac Output; Disease Models, Animal; Dobutamine; D | 1994 |
Neutrophil elastase inhibitor ICI 200,880 protects against attenuation of coronary flow reserve and myocardial dysfunction following temporary coronary artery occlusion in the dog.
Topics: Acetylcholine; Animals; Chemotaxis, Leukocyte; Constriction; Coronary Circulation; Coronary Vessels; | 1994 |
U-46619-induced ischaemic electrocardiographic changes in rats: preventive effects of prostacyclin and nitroglycerin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Analysis of Variance; Animals; B | 1994 |
Effect of FK409, a novel nitric oxide donor, on acute experimental myocardial ischemia.
Topics: Animals; Coronary Circulation; Coronary Vessels; Dipyridamole; Disease Models, Animal; Dogs; Electri | 1993 |
[Effects of carperitide (alpha-human atrial natriuretic peptide) on acute congestive heart failure in dogs].
Topics: Animals; Atrial Natriuretic Factor; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; | 1993 |
Inhibition of the biologic activity of tumor necrosis factor maintains vascular endothelial cell function during hyperdynamic sepsis.
Topics: Acetylcholine; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Dr | 1996 |
Nitric oxide donor alleviates ovariectomy-induced bone loss.
Topics: Absorptiometry, Photon; Analysis of Variance; Animals; Arginine; Bone Density; Disease Models, Anima | 1996 |
Effect of endotoxin-enhanced hepatic reperfusion injury on endothelium-dependent relaxation in rat aorta.
Topics: Acetylcholine; Animals; Antioxidants; Aorta, Thoracic; Bacterial Toxins; Constriction; Disease Model | 1996 |
Attenuation of lung graft reperfusion injury by a nitric oxide donor.
Topics: Animals; Cardioplegic Solutions; Disease Models, Animal; Disease Progression; Hemodynamics; Hydralaz | 1997 |
Nitroglycerin attenuates the bowel damage of necrotizing enterocolitis in a rabbit model.
Topics: Animals; Calcium Gluconate; Caseins; Disease Models, Animal; Enterocolitis, Pseudomembranous; Female | 1997 |
Reversal by L-arginine of a dysfunctional arginine/nitric oxide pathway in the endothelium of the genetic diabetic BB rat.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Cohort Studies; Diabetes Mellitus, Type 1; Diseas | 1997 |
Contrasting effects of conjugated estrogens and tamoxifen on dilator responses of atherosclerotic epicardial coronary arteries in nonhuman primates.
Topics: Acetylcholine; Animals; Arteriosclerosis; Body Weight; Cholesterol, HDL; Coronary Circulation; Diet, | 1997 |
Application of pharmacodynamic modeling for designing time-variant dosing regimens to overcome nitroglycerin tolerance in experimental heart failure.
Topics: Animals; Disease Models, Animal; Drug Delivery Systems; Drug Design; Drug Tolerance; Heart Failure; | 1997 |
Effects of inhalation of nitroglycerin on hypoxic pulmonary vasoconstriction.
Topics: Administration, Inhalation; Analysis of Variance; Animals; Blood Pressure; Cardiac Output; Disease M | 1998 |
Delapril slows the progression of atherosclerosis and maintains endothelial function in cholesterol-fed rabbits.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Abdominal; Aorta, Thoracic; Arterioscleros | 1998 |
Controlled delivery of vascular endothelial growth factor promotes neovascularization and maintains limb function in a rabbit model of ischemia.
Topics: Analysis of Variance; Angiography; Animals; Capillaries; Disease Models, Animal; Endothelial Growth | 1998 |
Beneficial hemodynamic effects of nicorandil in a canine model of acute congestive heart failure: comparison with nitroglycerin and cromakalim.
Topics: Acute Disease; Animals; Blood Pressure; Coronary Circulation; Cromakalim; Disease Models, Animal; Do | 1998 |
Acute effects of toborinone on vascular capacitance and conductance in experimental heart failure.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Dogs; Enalaprilat; Female; Heart Failure; Hemod | 1998 |
Vasopressin combined with nitroglycerin increases endocardial perfusion during cardiopulmonary resuscitation in pigs.
Topics: Analysis of Variance; Animals; Cardiopulmonary Resuscitation; Coronary Circulation; Disease Models, | 1998 |
In-utero and neonatal exposure to secondhand smoke causes vascular dysfunction in newborn rats.
Topics: Acetylcholine; Animals; Animals, Newborn; Aorta, Thoracic; Calcimycin; Cotinine; Disease Models, Ani | 1998 |
Relationship between arterial baroreflex, cardiopulmonary vagal reflex and renal natriuretic response to saline in conscious rabbits.
Topics: Animals; Baroreflex; Blood Pressure; Cardiovascular System; Disease Models, Animal; Female; Heart Ra | 1998 |
Effects of topical nitroglycerin and flurbiprofen in the rat comb burn model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Disease Models, Animal; Evaluation Studies | 1999 |
Superior protection in orthotopic rat lung transplantation with cyclic adenosine monophosphate and nitroglycerin-containing preservation solution.
Topics: Adenosine; Allopurinol; Animals; Capillary Permeability; Cyclic AMP; Dextrans; Disease Models, Anima | 1999 |
Systemic nitroglycerin increases nNOS levels in rat trigeminal nucleus caudalis.
Topics: Animals; Cell Count; Cerebral Arteries; Cerebrovascular Circulation; Disease Models, Animal; Male; M | 2000 |
The effect of raloxifene on coronary arteries in aged ovariectomized ewes.
Topics: Animals; Cholesterol; Coronary Angiography; Coronary Vessels; Disease Models, Animal; Estradiol; Fem | 2000 |
Enhancement of nitroglycerin induced blood vessel relaxation in chronic renal failure model rats.
Topics: Adenine; Animals; Aorta; Aryl Hydrocarbon Hydroxylases; Blood Urea Nitrogen; Cyclic GMP; Cytochrome | 1999 |
A controlled trial of topical nitroglycerin in a New Zealand white rabbit model of brown recluse spider envenomation.
Topics: Administration, Cutaneous; Analysis of Variance; Animals; Blood Urea Nitrogen; Creatine Kinase; Crea | 2001 |
Reciprocal regulation of cGMP-mediated vasorelaxation by soluble and particulate guanylate cyclases.
Topics: Animals; Aorta; Atrial Natriuretic Factor; Cyclic GMP; Disease Models, Animal; Dose-Response Relatio | 2001 |
Comparative effects of beraprost, a stable analogue of prostacyclin, with PGE(1), nitroglycerin and nifedipine on canine model of vasoconstrictive pulmonary hypertension.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alprostadil; Animals; Antihypert | 2001 |
Inhibitory effects of verapamil and nitroglycerin on contraction and cytosolic Ca2+ levels in cerebrovascular smooth muscle during chronic cerebral vasospasm.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Chronic Disease; Cytosol; Disease Models, Anima | 2001 |
Vasopeptidase inhibition in a canine model of exercise-induced left ventricular dysfunction.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Disease Models, Animal; Dogs; Female; Hemodynamic | 2002 |
Pharmacology of Sch 11973, N-(2-phenylisopropyl)-N-p-toluene sulfonyl urea, a potential new antianginal agent.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Animals; Coronary Disease; Dipyridamole; Disease Model | 1977 |
[Nitroglycerin in experimental myocardial infarction in the baboon. The effect of reducing the pre-charge and post-charge on regional myocardial function].
Topics: Animals; Disease Models, Animal; Haplorhini; Male; Myocardial Infarction; Nitroglycerin; Papio | 1978 |
Acute coronary occlusion in the pig: effect of nitroglycerin on regional myocardial blood flow.
Topics: Animals; Collateral Circulation; Coronary Circulation; Coronary Disease; Disease Models, Animal; Dog | 1978 |
The isoproterenol stress test in unanesthetized atherosclerotic rabbits.
Topics: Animals; Arteriosclerosis; Coronary Disease; Dipyridamole; Disease Models, Animal; Electrocardiograp | 1978 |
[Effects of nitroglycerine administered by intravenous infusion upon coronary flow and cardiac metabolism. Continuous study during experimental myocardial infarction].
Topics: Animals; Coronary Circulation; Disease Models, Animal; Dogs; Female; Infusions, Parenteral; Male; My | 1979 |
Abnormal myocardial fluid retention as an early manifestation of ischemic injury.
Topics: Adenosine; Adenosine Triphosphatases; Animals; Cell Membrane; Coronary Circulation; Coronary Disease | 1977 |
Comparison of nitroglycerin-, nitroprusside-, and phentolamine-induced changes in coronary collateral function in dogs.
Topics: Animals; Blood Pressure; Coronary Circulation; Disease Models, Animal; Dogs; Ferricyanides; Heart; K | 1977 |
Reduction of ischemic injury by nitroglycerin during acute myocardial infarction.
Topics: Acute Disease; Animals; Arrhythmias, Cardiac; Blood Pressure; Collateral Circulation; Coronary Circu | 1975 |
Glycogen metabolism and the effect of nitroglycerin on the glycogen metabolism in the normal and ischemic canine myocardium.
Topics: Adenosine Triphosphate; Animals; Coronary Disease; Depression, Chemical; Disease Models, Animal; Dog | 1975 |
Electrophysiologic effects of nitroglycerin during experimental coronary occlusion.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Circulation; Coronary Disease; Disease Model | 1975 |
Nitroglycerin and dipyridamole on cardiac metabolism and dynamics in a new experimental model of angina pectoris.
Topics: Angina Pectoris; Animals; Blood Pressure; Cardiac Output; Coronary Circulation; Dipyridamole; Diseas | 1976 |
Reduction in infarct size following experimental coronary occlusion by administration of verapamil.
Topics: Animals; Blood Pressure; Cardiac Output; Coronary Circulation; Coronary Disease; Disease Models, Ani | 1975 |
[The effect of carbocromen on the ST segment of the epicardial electrocardiogram in a model of intermitting myocardial ischemia (author's transl)].
Topics: Animals; Blood Pressure; Chromonar; Coronary Circulation; Coronary Disease; Coumarins; Disease Model | 1976 |
Behavioural changes in rats suggesting drug-induced headache [proceedings].
Topics: Animals; Avoidance Learning; Behavior, Animal; Disease Models, Animal; Drug Tolerance; Headache; Nit | 1976 |
Efficacy of the glyceryl trinitrate transdermal therapeutic system in a dog model of heart failure.
Topics: Administration, Cutaneous; Animals; Cardiac Output; Dextrans; Disease Models, Animal; Dogs; Female; | 1991 |
Modulation of baroreflex and baroreceptor function in experimental heart failure.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dogs; Electrophysiology; Heart Failure; Heart Rate; | 1991 |
Differential hemodynamic effects and tolerance properties of nitroglycerin and an S-nitrosothiol in experimental heart failure.
Topics: Animals; Disease Models, Animal; Drug Tolerance; Heart; Heart Failure; Hemodynamics; Infusions, Intr | 1991 |
[Effects of verapamil and nitroglycerin on experimental occlusion- reperfusion-induced myocardial infarction in rabbits].
Topics: Animals; Coronary Vessels; Disease Models, Animal; Drug Evaluation, Preclinical; Ligation; Male; Myo | 1991 |
Effects of chronic glyceryl trinitrate on left ventricular haemodynamics in a rat model of congestive heart failure: demonstration of a simple animal model for the study of in vivo nitrate tolerance.
Topics: Animals; Blood Pressure; Disease Models, Animal; Drug Tolerance; Heart Failure; Heart Ventricles; Ma | 1990 |
Efficacy of the glyceryl trinitrate transdermal therapeutic system in a dog model of myocardial ischaemia.
Topics: Administration, Cutaneous; Angiotensin II; Animals; Blood Pressure; Coronary Circulation; Coronary D | 1989 |
Different hemodynamic effects of atrial natriuretic factor and nitroglycerin in rats with congestive heart failure.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Diastole; Disease Models, Animal; Heart Failure; | 1989 |
A biochemical method for the quantitation of myocardial scarring after experimental coronary artery occlusion.
Topics: Animals; Arteries; Chloramines; Collagen; Coronary Vessels; Disease Models, Animal; Heart Ventricles | 1986 |
[Mechanisms of nitroglycerin action in experimental coronary insufficiency].
Topics: Animals; Coronary Circulation; Coronary Disease; Diastole; Disease Models, Animal; Dogs; Drug Evalua | 1987 |
Neither nitroglycerin nor nitroprusside selectively reduces sepsis-induced pulmonary hypertension in piglets.
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Drug Evaluation, Preclinical; Ferricyanides; | 1987 |
Effect of nitroglycerin on myocardial collateral conductance in awake dogs.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Disease; Coronary Vessels; Disease Models, A | 1988 |
Vasodilator therapy in vasoconstrictor-induced pulmonary hypertension in sheep.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Alprostadil; Animals; Disease Mo | 1988 |
Efficacy of vasodilator therapy in canine model of acute pulmonary hypertension.
Topics: Alprostadil; Animals; Coronary Circulation; Disease Models, Animal; Dogs; Female; Heart Ventricles; | 1988 |
[Pathophysiology and treatment of refractory asthma. 5. An animal model].
Topics: Animals; Asthma; Calcium Channel Blockers; Disease Models, Animal; Guinea Pigs; In Vitro Techniques; | 1988 |
Beneficial electrophysiologic effects of nitroglycerin during acute myocardial infarction.
Topics: Animals; Blood Pressure; Coronary Circulation; Disease Models, Animal; Dogs; Electric Stimulation; E | 1974 |
Nitroglycerin-induced reduction in the incidence of spontaneous ventricular fibrillation during coronary occlusion in dogs.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Dogs; Elect | 1974 |
Isoproterenol-induced cardiomegaly: assessment of myocardial protein content, actomyosin ATPase and heart rate.
Topics: Actomyosin; Adenosine Triphosphatases; Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal | 1972 |
[Physiology of the coronary circulation as a basis for evaluating coronary dilators].
Topics: Animals; Blood Pressure; Carbon Dioxide; Coronary Circulation; Coronary Vessels; Disease Models, Ani | 1972 |
Effect of ischemia and antianginal drugs on the distribution of radioactive microspheres in the canine left ventricle.
Topics: Angina Pectoris; Animals; Carbon; Cesium Isotopes; Chromium Isotopes; Collateral Circulation; Corona | 1971 |
Left ventricular performance and coronary flow after coronary embolization with plastic microspheres.
Topics: Animals; Atropine; Blood Pressure; Cardiac Output; Coronary Circulation; Disease Models, Animal; Dog | 1971 |