nitroglycerin has been researched along with Diabetes Mellitus, Type 2 in 69 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Insulin resistance is related to the atherosclerotic process." | 5.34 | Association between insulin resistance and endothelial dysfunction in type 2 diabetes and the effects of pioglitazone. ( Harano, Y; Suzuki, M; Takamisawa, I; Yoshimasa, Y, 2007) |
| "This study sought to examine the efficacy of ranolazine versus placebo on weekly angina frequency and sublingual nitroglycerin use in subjects with type 2 diabetes mellitus, coronary artery disease (CAD), and chronic stable angina who remain symptomatic despite treatment with up to 2 antianginal agents." | 5.17 | Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina). ( Arnold, SV; Belardinelli, L; Ben-Yehuda, O; Chaitman, BR; Jones, PG; Katz, A; Kosiborod, M; Li, Y; McGuire, DK; Olmsted, A; Spertus, JA; Yue, P, 2013) |
| "We compared flow-mediated dilatation (FMD) and nitroglycerine-dependent dilatation (NDD) in African-American diabetic subjects with persistent microalbuminuria (n = 35) despite ACEI therapy and those in whom microalbuminuria had resolved (n = 15)." | 5.12 | Impaired vascular reactivity in African-American patients with type 2 diabetes mellitus and microalbuminuria or proteinuria despite angiotensin-converting enzyme inhibitor therapy. ( Asnani, S; Fonseca, V; Jawa, A; Nachimuthu, S; Pendergrass, M, 2006) |
| " As folates may potentially reverse the uncoupling of NO synthase, we wanted to determine whether folic acid supplementation could modulate endothelial function and markers of inflammation in patients with type 2 diabetes without vascular disease." | 5.12 | Folic acid improves endothelial dysfunction in type 2 diabetes--an effect independent of homocysteine-lowering. ( Giddens, K; McQueen, MJ; Nassar, BA; Title, LM; Ur, E, 2006) |
| " We examined the effects of an intravenous infusion of L-arginine and a sublingual administration of nitroglycerin on the brachial, retinal, and interlobar arterial hemodynamics in 20 type 2 diabetic patients (10 with normoalbuminuria and 10 with microalbuminuria) and 10 aged-matched control subjects." | 5.09 | Impaired endothelium-dependent vascular responses of retinal and intrarenal arteries in patients with type 2 diabetes. ( Emoto, M; Inaba, M; Ishimura, E; Kanda, H; Kawagishi, T; Matsuyoshi, M; Morii, H; Nishizawa, Y; Okuno, Y; Taniwaki, H, 1999) |
| " In the present study we evaluated resistive index at baseline and after vasodilation induced by nitroglycerine in normoalbuminuric patients with type 2 diabetes or essential hypertension, relating the values to indices of systemic vascular dysfunction." | 3.77 | Dynamic evaluation of renal resistive index in normoalbuminuric patients with newly diagnosed hypertension or type 2 diabetes. ( Bruno, RM; Daghini, E; Di Paco, I; Ghiadoni, L; Landini, L; Magagna, A; Salvati, A; Santini, E; Solini, A; Taddei, S; Versari, D, 2011) |
| " In all patients, insulin resistance, residual pancreatic C-peptide secretion, endothelial function and oxidative stress were investigated using the homoeostasis model assessment (HOMA) index, glucagon bolus test, brachial reactivity, Trolox equivalent antioxidant capacity (TEAC) and thiobarbituric acid-reacting substances (TBARS)." | 3.72 | Residual C-peptide secretion and endothelial function in patients with Type II diabetes. ( Abbatecola, AM; Grella, R; Manzella, D; Paolisso, G; Ragno, E, 2003) |
| "Dislipidaemia in type 2 diabetes mellitus contributes to arterial endothelial dysfunction and an increased risk of cardiovascular disease." | 2.80 | Fenofibrate effects on arterial endothelial function in adults with type 2 diabetes mellitus: A FIELD substudy. ( Celermajer, DS; Harmer, JA; Keech, AC; Marwick, TH; Meredith, IT; Skilton, MR; Veillard, AS; Watts, GF, 2015) |
| "In adults with type 2 diabetes and known or suspected atherosclerosis, arterial smooth muscle-dependent dilatation was shown to be significantly impaired in cigarette smokers and those with elevated urinary albumin levels." | 2.79 | Cigarette smoking and albuminuria are associated with impaired arterial smooth muscle function in patients with type 2 diabetes mellitus: a FIELD substudy. ( Celermajer, DS; Harmer, JA; Keech, AC; Marwick, TH; Meredith, IT; Skilton, MR; Veillard, AS; Watts, GF, 2014) |
| "The treatment of type 2 diabetes mellitus patients with sitagliptin reverses vascular endothelial dysfunction, as evidenced by increase in the FMD, and improvement of the adiponectin levels." | 2.77 | The dipeptidyl peptidase-4 inhibitor sitagliptin improves vascular endothelial function in type 2 diabetes. ( Ikeda, T; Kirinoki-Ichikawa, S; Kubota, Y; Miyamoto, M; Mizuno, K; Takagi, G; Tanaka, K, 2012) |
| "A total of 30 subjects with type 2 diabetes were included in this randomized, controlled, double-blinded, parallel group study." | 2.75 | Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial. ( Francesconi, M; Gouya, G; Heinisch, BB; Mittermayer, F; Pleiner, J; Schaller, G; Wolzt, M, 2010) |
| "Patients with type 2 diabetes have abnormal endothelial function but it is not certain whether improvements in glycaemic control will improve endothelial function." | 2.70 | Effects of improved glycaemic control on endothelial function in patients with type 2 diabetes. ( Bagg, W; Braatvedt, GD; Drury, PL; Gamble, G; Sharpe, N; Whalley, GA, 2001) |
| "A subset of individuals with type 1 or type 2 diabetes (n = 108) was re-evaluated after 5 years." | 1.72 | Metabolic Factors Predict Changes in Endothelial Function During the Early Course of Type 1 and Type 2 Diabetes. ( Antoniou, S; Bódis, K; Burkart, V; Karusheva, Y; Löffler, L; Möser, C; Roden, M; Schön, M; Strassburger, K; Szendroedi, J; Yurchenko, I; Zaharia, OP, 2022) |
| "These results demonstrate that an increased EETs degradation by sEH and altered NO bioavailability are associated with conduit artery endothelial dysfunction in type 2 diabetic patients independently from their hypertensive status." | 1.51 | Altered bioavailability of epoxyeicosatrienoic acids is associated with conduit artery endothelial dysfunction in type 2 diabetic patients. ( Bellien, J; Cailleux, AF; Duflot, T; Iacob, M; Joannidès, R; Lamoureux, F; Leuillier, M; Li, D; Moreau-Grangé, L; Morisseau, C; Prévost, G; Rémy-Jouet, I; Renet, S; Richard, V; Roche, C; Wils, J, 2019) |
| "Acute myocardial infarction is a rare complication of dobutamine stress echocardiography." | 1.39 | [Acute myocardial infarction complicated by acute pulmonary oedema and cardiogenic collapse during dobutamine stress echocardiography]. ( Diack, B; Diagne-Sow, D; Dioum, M; Kagambega, LJ; Kane, A; Kane, M; Mbaye, A; Yameogo, NV, 2013) |
| " One of the earliest events in the development of atherosclerosis is endothelial dysfunction, namely, a reduction in nitric oxide (NO) synthesis or its bioavailability within the peri-endothelial environment, where it is responsible for maintenance of vascular tissue integrity." | 1.38 | Endothelial dysfunction in type 2 diabetes. ( Ferrannini, E; Natali, A, 2012) |
| "Bilirubin levels were higher in the type 2 diabetes group (0." | 1.35 | Total serum bilirubin does not affect vascular reactivity in patients with diabetes. ( Doupis, J; Horr, S; Malhotra, A; Rahangdale, S; Veves, A; Yeh, SY, 2009) |
| "The impairment of reactive hyperemia due to microvascular dysfunction in diabetes might cause an insufficient increase in shear stress stimulating the endothelial NO release, thus leading to an underestimation of FMD." | 1.35 | Impaired flow-mediated vasodilation in type 2 diabetes: lack of relation to microvascular dysfunction. ( Lieps, D; Meyer, MF; Pfohl, M; Schatz, H, 2008) |
| "Insulin resistance is related to the atherosclerotic process." | 1.34 | Association between insulin resistance and endothelial dysfunction in type 2 diabetes and the effects of pioglitazone. ( Harano, Y; Suzuki, M; Takamisawa, I; Yoshimasa, Y, 2007) |
| "Thus, type II diabetes mellitus impairs nitric oxide synthase-dependent responses of cerebral arterioles." | 1.32 | Impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type II diabetic rats. ( Mayhan, WG; Schwaninger, RM; Sun, H, 2003) |
| "Both uncontrolled hypertension and type II diabetes mellitus, but not smoking, are associated with impaired vascular smooth-muscle reactivity induced by NO donors." | 1.32 | Uncontrolled hypertension, uncompensated type II diabetes, and smoking have different patterns of vascular dysfunction. ( Cittadino, M; Moreno, H; Sabha, M; Sousa, MG; Tácito, LH; Tanus-Santos, JE; Yugar-Toledo, JC, 2004) |
| "The haemodynamic consequence of altered mechanical wall properties in diabetes can impair the compliance characteristics or pulsatile function of arteries before changes in calibre or peripheral resistance become evident." | 1.31 | Early vascular abnormalities and de novo nitrate tolerance in diabetes mellitus. ( Allen, P; Dixon, LJ; Hamilton, P; Hayes, JR; McVeigh, GE; Morgan, DR; Silke, B; Trimble, M, 2002) |
| "Type 2 diabetes is associated with an increased risk of cardiovascular disease." | 1.31 | Impaired vascular reactivity is present despite normal levels of von Willebrand factor in patients with uncomplicated Type 2 diabetes. ( Eskildsen, PC; Ihlemann, N; Stokholm, KH, 2002) |
| "In contrast, the NIDDM patients showed an impaired FAD% (3." | 1.30 | Preserved endothelial function in IDDM patients, but not in NIDDM patients, compared with healthy subjects. ( Benda, N; Enderle, MD; Haering, HU; Pfohl, M; Schmuelling, RM, 1998) |
| "In patients with type 2 diabetes mellitus, dyslipidemia is mainly characterized by hypertriglyceridemia, low high density lipoprotein, and a preponderance of small dense low density lipoprotein (LDL) particles." | 1.30 | Influence of low density lipoprotein (LDL) subfraction profile and LDL oxidation on endothelium-dependent and independent vasodilation in patients with type 2 diabetes. ( Ai, VH; Chau, MT; Chow, WS; Lam, KS; Leong, L; Tan, KC, 1999) |
| "Twenty patients with CAD and NIDDM (diabetics), and 20 patients with only CAD (nondiabetics) were evaluated." | 1.30 | Coronary artery distensibility in diabetic patients with simultaneous measurements of luminal area and intracoronary pressure: evidence of impaired reactivity to nitroglycerin. ( Stefanadis, C; Toutouzas, K; Toutouzas, P; Triandaphyllidi, E; Vavuranakis, M, 1999) |
| "To evaluate 1) the hemorrheologic and hemodynamic effects of glyceryl trinitrate in patients with non-insulin-dependent diabetes mellitus and 2) the influence of antioxidants on these effects." | 1.29 | Abnormal rheologic effects of glyceryl trinitrate in patients with non-insulin-dependent diabetes mellitus and reversal by antioxidants. ( Acampora, R; Coppola, L; D'Onofrio, F; Donzella, C; Giugliano, D; Marfella, R; Quatraro, A; Verrazzo, G, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.45) | 18.7374 |
| 1990's | 12 (17.39) | 18.2507 |
| 2000's | 34 (49.28) | 29.6817 |
| 2010's | 20 (28.99) | 24.3611 |
| 2020's | 2 (2.90) | 2.80 |
| Authors | Studies |
|---|---|
| Calderone, V | 1 |
| Rapposelli, S | 1 |
| Martelli, A | 1 |
| Digiacomo, M | 1 |
| Testai, L | 1 |
| Torri, S | 1 |
| Marchetti, P | 1 |
| Breschi, MC | 1 |
| Balsamo, A | 1 |
| Zaharia, OP | 1 |
| Schön, M | 1 |
| Löffler, L | 1 |
| Strassburger, K | 1 |
| Möser, C | 1 |
| Yurchenko, I | 1 |
| Bódis, K | 1 |
| Antoniou, S | 1 |
| Karusheva, Y | 1 |
| Szendroedi, J | 1 |
| Burkart, V | 1 |
| Roden, M | 1 |
| Van Hove, L | 1 |
| Schlögl, M | 1 |
| Hofmänner, D | 1 |
| Manka, R | 1 |
| Keller, DI | 1 |
| Duflot, T | 1 |
| Moreau-Grangé, L | 1 |
| Roche, C | 1 |
| Iacob, M | 1 |
| Wils, J | 1 |
| Rémy-Jouet, I | 1 |
| Cailleux, AF | 1 |
| Leuillier, M | 1 |
| Renet, S | 1 |
| Li, D | 1 |
| Morisseau, C | 1 |
| Lamoureux, F | 1 |
| Richard, V | 1 |
| Prévost, G | 1 |
| Joannidès, R | 1 |
| Bellien, J | 1 |
| Kosiborod, M | 2 |
| Arnold, SV | 2 |
| Spertus, JA | 2 |
| McGuire, DK | 2 |
| Li, Y | 2 |
| Yue, P | 2 |
| Ben-Yehuda, O | 2 |
| Katz, A | 1 |
| Jones, PG | 1 |
| Olmsted, A | 1 |
| Belardinelli, L | 1 |
| Chaitman, BR | 1 |
| Yameogo, NV | 1 |
| Mbaye, A | 1 |
| Kagambega, LJ | 1 |
| Dioum, M | 1 |
| Diagne-Sow, D | 1 |
| Kane, M | 1 |
| Diack, B | 1 |
| Kane, A | 1 |
| Hartman, ML | 1 |
| Shirihai, OS | 1 |
| Holbrook, M | 1 |
| Xu, G | 1 |
| Kocherla, M | 1 |
| Shah, A | 1 |
| Fetterman, JL | 1 |
| Kluge, MA | 1 |
| Frame, AA | 1 |
| Hamburg, NM | 1 |
| Vita, JA | 1 |
| Schreuder, TH | 1 |
| Green, DJ | 1 |
| Nyakayiru, J | 1 |
| Hopman, MT | 1 |
| Thijssen, DH | 1 |
| Harmer, JA | 2 |
| Keech, AC | 2 |
| Veillard, AS | 2 |
| Skilton, MR | 2 |
| Marwick, TH | 2 |
| Watts, GF | 4 |
| Meredith, IT | 2 |
| Celermajer, DS | 2 |
| Page, RL | 1 |
| Ghushchyan, V | 1 |
| Read, RA | 1 |
| Hartsfield, CL | 1 |
| Koch, BR | 1 |
| Nair, KV | 1 |
| Agrawal, RP | 1 |
| Goswami, J | 1 |
| Jain, S | 1 |
| Kochar, DK | 1 |
| Yeh, SY | 1 |
| Doupis, J | 1 |
| Rahangdale, S | 1 |
| Horr, S | 1 |
| Malhotra, A | 1 |
| Veves, A | 2 |
| Schaller, G | 2 |
| Kretschmer, S | 1 |
| Gouya, G | 2 |
| Haider, DG | 1 |
| Mittermayer, F | 2 |
| Riedl, M | 1 |
| Wagner, O | 1 |
| Pacini, G | 1 |
| Wolzt, M | 2 |
| Ludvik, B | 1 |
| Heinisch, BB | 1 |
| Francesconi, M | 1 |
| Pleiner, J | 1 |
| Kizhakekuttu, TJ | 1 |
| Gutterman, DD | 1 |
| Phillips, SA | 1 |
| Jurva, JW | 1 |
| Arthur, EI | 1 |
| Das, E | 1 |
| Widlansky, ME | 1 |
| Dekker, D | 1 |
| Dorresteijn, MJ | 1 |
| Pijnenburg, M | 1 |
| Heemskerk, S | 1 |
| Rasing-Hoogveld, A | 1 |
| Burger, DM | 1 |
| Wagener, FA | 1 |
| Smits, P | 1 |
| Madden, KM | 1 |
| Lockhart, CK | 1 |
| Potter, TF | 1 |
| Cuff, DJ | 1 |
| Meneilly, GS | 1 |
| Bruno, RM | 1 |
| Daghini, E | 1 |
| Landini, L | 1 |
| Versari, D | 1 |
| Salvati, A | 1 |
| Santini, E | 1 |
| Di Paco, I | 1 |
| Magagna, A | 1 |
| Taddei, S | 1 |
| Ghiadoni, L | 2 |
| Solini, A | 1 |
| Natali, A | 1 |
| Ferrannini, E | 1 |
| Chan, DC | 1 |
| Wong, AT | 1 |
| Yamashita, S | 1 |
| Naka, KK | 1 |
| Papathanassiou, K | 1 |
| Bechlioulis, A | 1 |
| Kazakos, N | 1 |
| Pappas, K | 1 |
| Tigas, S | 1 |
| Makriyiannis, D | 1 |
| Tsatsoulis, A | 1 |
| Michalis, LK | 1 |
| Kubota, Y | 1 |
| Miyamoto, M | 1 |
| Takagi, G | 1 |
| Ikeda, T | 1 |
| Kirinoki-Ichikawa, S | 1 |
| Tanaka, K | 1 |
| Mizuno, K | 1 |
| Komatsu, M | 1 |
| Kawagishi, T | 3 |
| Emoto, M | 3 |
| Shoji, T | 2 |
| Yamada, A | 1 |
| Sato, K | 1 |
| Hosoi, M | 1 |
| Nishizawa, Y | 3 |
| Bilsborough, W | 1 |
| O'Driscoll, G | 1 |
| Stanton, K | 1 |
| Weerasooriya, R | 1 |
| Dembo, L | 1 |
| Taylor, R | 1 |
| Green, D | 1 |
| McVeigh, GE | 2 |
| Morgan, DR | 1 |
| Allen, P | 1 |
| Trimble, M | 1 |
| Hamilton, P | 1 |
| Dixon, LJ | 1 |
| Silke, B | 1 |
| Hayes, JR | 2 |
| Fernández-Real, JM | 3 |
| Peñarroja, G | 3 |
| Castro, A | 3 |
| García-Bragado, F | 1 |
| López-Bermejo, A | 2 |
| Ricart, W | 3 |
| Richart, C | 2 |
| Vendrell, J | 2 |
| Broch, M | 2 |
| Manzella, D | 1 |
| Ragno, E | 1 |
| Abbatecola, AM | 1 |
| Grella, R | 1 |
| Paolisso, G | 1 |
| Rayman, G | 1 |
| Baker, NR | 1 |
| Krishnan, ST | 1 |
| Schwaninger, RM | 1 |
| Sun, H | 1 |
| Mayhan, WG | 1 |
| Economides, PA | 1 |
| Caselli, A | 1 |
| Tiani, E | 1 |
| Khaodhiar, L | 1 |
| Horton, ES | 1 |
| Yugar-Toledo, JC | 1 |
| Tanus-Santos, JE | 1 |
| Sabha, M | 1 |
| Sousa, MG | 1 |
| Cittadino, M | 1 |
| Tácito, LH | 1 |
| Moreno, H | 1 |
| Nyström, T | 2 |
| Gutniak, MK | 1 |
| Zhang, Q | 1 |
| Zhang, F | 1 |
| Holst, JJ | 1 |
| Ahrén, B | 1 |
| Sjöholm, A | 2 |
| Nygren, A | 1 |
| Spijkerman, AM | 1 |
| Smulders, YM | 1 |
| Kostense, PJ | 1 |
| Henry, RM | 1 |
| Becker, A | 1 |
| Teerlink, T | 1 |
| Jakobs, C | 1 |
| Dekker, JM | 1 |
| Nijpels, G | 1 |
| Heine, RJ | 1 |
| Bouter, LM | 1 |
| Stehouwer, CD | 1 |
| McErlane, K | 1 |
| Jawa, A | 1 |
| Nachimuthu, S | 1 |
| Pendergrass, M | 1 |
| Asnani, S | 1 |
| Fonseca, V | 1 |
| Hofma, SH | 1 |
| van der Giessen, WJ | 1 |
| van Dalen, BM | 1 |
| Lemos, PA | 1 |
| McFadden, EP | 1 |
| Sianos, G | 1 |
| Ligthart, JM | 1 |
| van Essen, D | 1 |
| de Feyter, PJ | 1 |
| Serruys, PW | 1 |
| Anderson, RA | 1 |
| Ellis, GR | 1 |
| Evans, LM | 1 |
| Morris, K | 1 |
| Chirkov, YY | 1 |
| Horowitz, JD | 1 |
| Jackson, SK | 1 |
| Rees, A | 1 |
| Lewis, MJ | 1 |
| Frenneaux, MP | 1 |
| Chan, WB | 1 |
| Chan, NN | 1 |
| Lai, CW | 1 |
| So, WY | 1 |
| Lo, MK | 1 |
| Lee, KF | 1 |
| Chow, CC | 1 |
| Metreweli, C | 1 |
| Chan, JC | 1 |
| Title, LM | 1 |
| Ur, E | 1 |
| Giddens, K | 1 |
| McQueen, MJ | 1 |
| Nassar, BA | 1 |
| Suzuki, M | 1 |
| Takamisawa, I | 1 |
| Yoshimasa, Y | 1 |
| Harano, Y | 1 |
| Yee, J | 1 |
| Meyer, MF | 1 |
| Lieps, D | 1 |
| Schatz, H | 1 |
| Pfohl, M | 2 |
| Giugliano, D | 1 |
| Marfella, R | 1 |
| Verrazzo, G | 1 |
| Acampora, R | 1 |
| Donzella, C | 1 |
| Quatraro, A | 1 |
| Coppola, L | 1 |
| D'Onofrio, F | 1 |
| Zhuplatov, SB | 1 |
| McVeigh, G | 1 |
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| Hayes, R | 1 |
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| Huvers, FC | 1 |
| Schaper, NC | 1 |
| Houben, AJ | 1 |
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| Kitslaar, PJ | 1 |
| De Leeuw, PW | 1 |
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| Mularoni, EM | 1 |
| Burzacca, S | 1 |
| Ponziani, MC | 1 |
| Massucco, P | 1 |
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| Cavalot, F | 1 |
| Trovati, M | 1 |
| Enderle, MD | 1 |
| Benda, N | 1 |
| Schmuelling, RM | 1 |
| Haering, HU | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective Study on Diabetes Mellitus and Its Complications in Newly Diagnosed Adult Patients[NCT01055093] | 2,000 participants (Anticipated) | Observational | 2005-09-30 | Recruiting | |||
| Determination of the Mechanisms Involved in Conduit Artery Endothelial Dysfunction in Type 2 Diabetes[NCT02311075] | 48 participants (Actual) | Interventional | 2014-12-31 | Completed | |||
| A Phase 4, Randomized, Double-Blind, Placebo-Controlled, Parallel Study of Ranolazine in Subjects With Chronic Stable Angina and Coronary Artery Disease With a History of Type 2 Diabetes Mellitus[NCT01425359] | Phase 4 | 949 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| Does Ranolazine Decrease Biomarkers That Indicate Evidence of Myocardial Damage in Diabetics With Stable Ischemic Heart Disease? A Double-blinded, Randomized, Placebo Controlled Trial[NCT02611596] | 0 participants (Actual) | Interventional | 2016-11-30 | Withdrawn | |||
| Effect of Anti-diabetic Drugs on Glycemic Variability. A Comparison Between Gliclazide MR (Modified Release) and Dapagliflozin on Glycemic Variability Measured by Continuous Glucose Monitoring (CGM) in Patients With Uncontrolled Type 2 Diabetes[NCT02925559] | Phase 4 | 135 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| A Physiologic Comparison of Two Approaches to Treating Peripheral Neuropathy[NCT05577390] | 40 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | |||
| Endothelial and Metabolic Effects of GLP-1 in Coronary Circulation in Patients With Type 2 Diabetes Mellitus[NCT00923962] | 35 participants (Actual) | Interventional | 2009-06-30 | Completed | |||
| Effects on Re-endothelialisation With Bydureon Treatment Add on to Insulin Versus Insulin Alone, Both in Combination With Metformin in Type 2 Diabetic Subjects[NCT02621489] | Phase 4 | 38 participants (Actual) | Interventional | 2015-12-31 | Completed | ||
| Effect of GLP-1 on Microvascular Insulin Responses in Type 1 Diabetes[NCT04133922] | Early Phase 1 | 0 participants (Actual) | Interventional | 2019-10-14 | Withdrawn (stopped due to the study drug could not be obtained) | ||
| Magnetic Resonance Assessment of Victoza Efficacy in the Regression of Cardiovascular Dysfunction In Type 2 Diabetes Mellitus[NCT01761318] | Phase 4 | 50 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| Phase 4 Study of Randomized Comparison Among Oral Rapamycin Plus Bare Metal Stents Versus Drug Eluting Stents in de Novo Coronary Lesions.[NCT00552669] | Phase 4 | 200 participants (Actual) | Interventional | 2006-01-31 | Completed | ||
| Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System[NCT03109795] | Phase 4 | 30 participants (Actual) | Interventional | 2017-04-10 | Terminated (stopped due to Funding ended) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Average weekly angina frequency was defined as the total number of angina episodes reported during the last 6 weeks of treatment divided by 6 weeks.~For subjects who terminated with less than 6 weeks of treatment, frequency was calculated as the total number of angina episodes reported during the treatment period divided by the subject's actual duration of treatment." (NCT01425359)
Timeframe: 6 weeks
| Intervention | angina attacks per week (Mean) |
|---|---|
| Placebo | 5.2 |
| Ranolazine | 4.5 |
Average weekly frequency of sublingual nitroglycerin use was defined as the total number reported during the last 6 weeks of treatment divided by the duration corresponding to the last 6 weeks of treatment. (NCT01425359)
Timeframe: 6 weeks
| Intervention | nitroglycerin uses per week (Mean) |
|---|---|
| Placebo | 3.6 |
| Ranolazine | 2.9 |
The PGIC was completed at the end of treatment/last visit.The PGIC scale measures the change in the participant's overall status since the beginning of the study on a scale ranging from 1 (no change or worse) to 7 (very much improved). (NCT01425359)
Timeframe: 8 weeks
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 3.9 |
| Ranolazine | 4.0 |
(NCT01425359)
Timeframe: 6 weeks
| Intervention | percentage of weeks (Mean) |
|---|---|
| Placebo | 50 |
| Ranolazine | 54 |
For each participant, the percentage of the last 6 weeks on treatment during which the angina frequency was less than or equal to 50% of the baseline average weekly angina frequency was determined. (NCT01425359)
Timeframe: 6 weeks
| Intervention | percentage of weeks (Mean) |
|---|---|
| Placebo | 41 |
| Ranolazine | 46 |
The range of each health domain score is 0-100, with 0 indicating a poorer health state and 100 indicating a better health state. An increase in score indicates an improvement in health state. Participants were asked to complete the survey at randomization (prior to receiving treatment), and at end of treatment visit (Week 8) or early study drug discontinuation or early termination visit. The survey asked participants for responses specific to the preceding 4 weeks prior to completing the survey. (NCT01425359)
Timeframe: Up to 8 weeks
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Mental Component Score | Physical Component Score | |
| Placebo | 1.2 | 1.9 |
| Qualifying Phase: Participants Entered a 2-week Washout Period | 1.0 | 2.8 |
Overall costs expressed in US dollars at 18 months of follow up between Oral Sirolimus Plus BMS vs DES implantation in denovo coronary lesions. (NCT00552669)
Timeframe: Follow up will be conducted by the coordinating Center at 18 months of follow up
| Intervention | US dollars (Mean) |
|---|---|
| Oral Sirolimus + Bare Metal Stent | 5483 |
| Drug Eluting Stents | 7658.2 |
Efficacy end point was TVR as revasacularization of the treated vessel. (NCT00552669)
Timeframe: 18 months
| Intervention | vessels (Number) |
|---|---|
| Oral Sirolimus + Bare Metal Stent | 14 |
| Drug Eluting Stents | 15 |
Death from any cause, myocardial infarction and stroke. Safety was analyzed as MACCE (major adverse cardiovascular events) including death, MI and stroke. (NCT00552669)
Timeframe: 18 Months
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| MACCE | Death | Acute Myocardial Infarction | Stroke | |
| Drug Eluting Stents | 15 | 7 | 9 | 1 |
| Oral Sirolimus + Bare Metal Stent | 9 | 3 | 6 | 0 |
25 trials available for nitroglycerin and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina).
Topics: Acetanilides; Aged; Angina, Stable; Coronary Artery Disease; Diabetes Mellitus, Type 2; Double-Blind | 2013 |
Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina).
Topics: Acetanilides; Aged; Angina, Stable; Coronary Artery Disease; Diabetes Mellitus, Type 2; Double-Blind | 2013 |
Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina).
Topics: Acetanilides; Aged; Angina, Stable; Coronary Artery Disease; Diabetes Mellitus, Type 2; Double-Blind | 2013 |
Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina).
Topics: Acetanilides; Aged; Angina, Stable; Coronary Artery Disease; Diabetes Mellitus, Type 2; Double-Blind | 2013 |
Effects of ranolazine on quality of life among patients with diabetes mellitus and stable angina.
Topics: Acetanilides; Aged; Angina, Stable; Diabetes Mellitus, Type 2; Double-Blind Method; Enzyme Inhibitor | 2014 |
Cigarette smoking and albuminuria are associated with impaired arterial smooth muscle function in patients with type 2 diabetes mellitus: a FIELD substudy.
Topics: Aged; Albuminuria; Brachial Artery; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, V | 2014 |
Fenofibrate effects on arterial endothelial function in adults with type 2 diabetes mellitus: A FIELD substudy.
Topics: Aged; Australia; Brachial Artery; Diabetes Mellitus, Type 2; Double-Blind Method; Dyslipidemias; End | 2015 |
Management of diabetic neuropathy by sodium valproate and glyceryl trinitrate spray: a prospective double-blind randomized placebo-controlled study.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Diabetes Mellitus, Type 2; Diabetic Neuropathies; | 2009 |
Alcohol acutely increases vascular reactivity together with insulin sensitivity in type 2 diabetic men.
Topics: Aged; Alcohol Drinking; Body Mass Index; Brachial Artery; Diabetes Mellitus, Type 2; Endothelium, Va | 2010 |
Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial.
Topics: Acetylcholine; Antioxidants; Diabetes Mellitus, Type 2; Double-Blind Method; Endothelium, Vascular; | 2010 |
Measuring FMD in the brachial artery: how important is QRS gating?
Topics: Adolescent; Adult; Aged; Blood Flow Velocity; Blood Pressure; Brachial Artery; Case-Control Studies; | 2010 |
The bilirubin-increasing drug atazanavir improves endothelial function in patients with type 2 diabetes mellitus.
Topics: Acetylcholine; Aged; Atazanavir Sulfate; Bilirubin; Cross-Over Studies; Diabetes Mellitus, Type 2; D | 2011 |
Short-term aerobic exercise reduces nitroglycerin-induced orthostatic intolerance in older adults with type 2 diabetes.
Topics: Accidental Falls; Aged; Aged, 80 and over; Body Mass Index; Diabetes Mellitus, Type 2; Exercise; Fem | 2011 |
Apolipoprotein B-48 as a determinant of endothelial function in obese subjects with type 2 diabetes mellitus: effect of fenofibrate treatment.
Topics: Adult; Aged; Analysis of Variance; Apolipoprotein B-48; Apolipoprotein C-III; Brachial Artery; Chole | 2012 |
The dipeptidyl peptidase-4 inhibitor sitagliptin improves vascular endothelial function in type 2 diabetes.
Topics: Adiponectin; Aged; Aged, 80 and over; Atherosclerosis; Diabetes Mellitus, Type 2; Dipeptidyl-Peptida | 2012 |
Effect of lowering tumour necrosis factor-alpha on vascular endothelial function in Type II diabetes.
Topics: Acetylcholine; Analysis of Variance; Brachial Artery; Cross-Over Studies; Diabetes Mellitus, Type 2; | 2002 |
Blood letting in high-ferritin type 2 diabetes: effects on vascular reactivity.
Topics: Blood Flow Velocity; Blood Glucose; Blood Specimen Collection; Diabetes Mellitus, Type 2; Endotheliu | 2002 |
G protein beta3 gene variant, vascular function, and insulin sensitivity in type 2 diabetes.
Topics: Adult; Aged; Blood Glucose; Brachial Artery; Diabetes Mellitus, Type 2; Female; Heterotrimeric GTP-B | 2003 |
Glyceryl trinitrate patches as an alternative to isosorbide dinitrate spray in the treatment of chronic painful diabetic neuropathy.
Topics: Administration, Cutaneous; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathi | 2003 |
The effects of atorvastatin on endothelial function in diabetic patients and subjects at risk for type 2 diabetes.
Topics: Adult; Atorvastatin; Biomarkers; Brachial Artery; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type | 2004 |
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
Topics: Adult; Brachial Artery; Coronary Circulation; Coronary Disease; Coronary Vessels; Cross-Over Studies | 2004 |
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
Topics: Adult; Brachial Artery; Coronary Circulation; Coronary Disease; Coronary Vessels; Cross-Over Studies | 2004 |
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
Topics: Adult; Brachial Artery; Coronary Circulation; Coronary Disease; Coronary Vessels; Cross-Over Studies | 2004 |
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
Topics: Adult; Brachial Artery; Coronary Circulation; Coronary Disease; Coronary Vessels; Cross-Over Studies | 2004 |
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
Topics: Adult; Brachial Artery; Coronary Circulation; Coronary Disease; Coronary Vessels; Cross-Over Studies | 2004 |
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
Topics: Adult; Brachial Artery; Coronary Circulation; Coronary Disease; Coronary Vessels; Cross-Over Studies | 2004 |
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
Topics: Adult; Brachial Artery; Coronary Circulation; Coronary Disease; Coronary Vessels; Cross-Over Studies | 2004 |
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
Topics: Adult; Brachial Artery; Coronary Circulation; Coronary Disease; Coronary Vessels; Cross-Over Studies | 2004 |
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
Topics: Adult; Brachial Artery; Coronary Circulation; Coronary Disease; Coronary Vessels; Cross-Over Studies | 2004 |
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
Topics: Adult; Brachial Artery; Coronary Circulation; Coronary Disease; Coronary Vessels; Cross-Over Studies | 2004 |
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
Topics: Adult; Brachial Artery; Coronary Circulation; Coronary Disease; Coronary Vessels; Cross-Over Studies | 2004 |
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
Topics: Adult; Brachial Artery; Coronary Circulation; Coronary Disease; Coronary Vessels; Cross-Over Studies | 2004 |
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
Topics: Adult; Brachial Artery; Coronary Circulation; Coronary Disease; Coronary Vessels; Cross-Over Studies | 2004 |
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
Topics: Adult; Brachial Artery; Coronary Circulation; Coronary Disease; Coronary Vessels; Cross-Over Studies | 2004 |
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
Topics: Adult; Brachial Artery; Coronary Circulation; Coronary Disease; Coronary Vessels; Cross-Over Studies | 2004 |
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
Topics: Adult; Brachial Artery; Coronary Circulation; Coronary Disease; Coronary Vessels; Cross-Over Studies | 2004 |
S-adenosylmethionine and 5-methyltetrahydrofolate are associated with endothelial function after controlling for confounding by homocysteine: the Hoorn Study.
Topics: Aged; Brachial Artery; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diabetic Angiopathies; En | 2005 |
Impaired vascular reactivity in African-American patients with type 2 diabetes mellitus and microalbuminuria or proteinuria despite angiotensin-converting enzyme inhibitor therapy.
Topics: Adult; Aged; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inh | 2006 |
Folic acid improves endothelial dysfunction in type 2 diabetes--an effect independent of homocysteine-lowering.
Topics: Brachial Artery; C-Reactive Protein; Cross-Over Studies; Diabetes Mellitus, Type 2; Dietary Suppleme | 2006 |
Impaired endothelium-dependent vascular responses of retinal and intrarenal arteries in patients with type 2 diabetes.
Topics: Adult; Albuminuria; Arginine; Blood Glucose; Blood Pressure; Brachial Artery; Diabetes Mellitus, Typ | 1999 |
Mental stress induces transient endothelial dysfunction in humans.
Topics: Adult; Blood Flow Velocity; Blood Glucose; Brachial Artery; Cytokines; Diabetes Mellitus, Type 2; El | 2000 |
Effects of improved glycaemic control on endothelial function in patients with type 2 diabetes.
Topics: Blood Glucose; Brachial Artery; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Glipizide; | 2001 |
Noninvasive detection of endothelial dysfunction in elderly with NIDDM by ultrasonography.
Topics: Administration, Sublingual; Aged; Aging; Arteriosclerosis; Blood Flow Velocity; Brachial Artery; Dia | 2001 |
44 other studies available for nitroglycerin and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs.
Topics: Animals; Aorta; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypoglycemic Agents; Insulin; Islets o | 2009 |
Metabolic Factors Predict Changes in Endothelial Function During the Early Course of Type 1 and Type 2 Diabetes.
Topics: Brachial Artery; Diabetes Mellitus, Type 2; Endothelium, Vascular; Glucose; Glycated Hemoglobin; Hum | 2022 |
A Cannabinoid Type 2 (CB2) Receptor Agonist Augments NOS-Dependent Responses of Cerebral Arterioles During Type 1 Diabetes.
Topics: Adenosine Diphosphate; Animals; Arterioles; Cannabinoid Receptor Agonists; Cannabinoids; Diabetes Me | 2022 |
A foreign older diabetic woman with an acute myocardial infarction: when cognitive biases in clinical decision-making become especially important.
Topics: Aged, 80 and over; Angioplasty, Balloon, Coronary; Anticoagulants; Aspirin; Clinical Decision-Making | 2018 |
Altered bioavailability of epoxyeicosatrienoic acids is associated with conduit artery endothelial dysfunction in type 2 diabetic patients.
Topics: Aged; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Eicosanoid | 2019 |
[Acute myocardial infarction complicated by acute pulmonary oedema and cardiogenic collapse during dobutamine stress echocardiography].
Topics: Diabetes Mellitus, Type 2; Diuretics; Echocardiography, Stress; Furosemide; Heart Failure; Humans; M | 2013 |
Relation of mitochondrial oxygen consumption in peripheral blood mononuclear cells to vascular function in type 2 diabetes mellitus.
Topics: Adult; Aged; Brachial Artery; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Humans; Leuk | 2014 |
Time-course of vascular adaptations during 8 weeks of exercise training in subjects with type 2 diabetes and middle-aged controls.
Topics: Adaptation, Physiological; Aged; Brachial Artery; Case-Control Studies; Diabetes Mellitus, Type 2; E | 2015 |
Comparative Effectiveness of Ranolazine Versus Traditional Therapies in Chronic Stable Angina Pectoris and Concomitant Diabetes Mellitus and Impact on Health Care Resource Utilization and Cardiac Interventions.
Topics: Adrenergic beta-Antagonists; Aged; Angina, Stable; Calcium Channel Blockers; Cardiovascular Agents; | 2015 |
Total serum bilirubin does not affect vascular reactivity in patients with diabetes.
Topics: Acetylcholine; Administration, Cutaneous; Adult; Aged; Bilirubin; Brachial Artery; Cross-Sectional S | 2009 |
Dynamic evaluation of renal resistive index in normoalbuminuric patients with newly diagnosed hypertension or type 2 diabetes.
Topics: Adult; Albuminuria; Blood Glucose; Case-Control Studies; Comorbidity; Diabetes Mellitus, Type 2; Fem | 2011 |
Endothelial dysfunction in type 2 diabetes.
Topics: Arginine; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Humans; Ischemia; Male; Muscles; | 2012 |
Determinants of vascular function in patients with type 2 diabetes.
Topics: Adult; Aged; Aged, 80 and over; Arterial Pressure; Biomarkers; Blood Glucose; Brachial Artery; Carot | 2012 |
ecNOS gene polymorphism is associated with endothelium-dependent vasodilation in Type 2 diabetes.
Topics: Aged; Brachial Artery; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Gene Frequency; Gen | 2002 |
Early vascular abnormalities and de novo nitrate tolerance in diabetes mellitus.
Topics: Adult; Aged; Arteries; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; | 2002 |
Residual C-peptide secretion and endothelial function in patients with Type II diabetes.
Topics: Aged; Analysis of Variance; Area Under Curve; Brachial Artery; C-Peptide; Diabetes Mellitus, Type 2; | 2003 |
Impaired nitric oxide synthase-dependent dilatation of cerebral arterioles in type II diabetic rats.
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Arterioles; Blotting, Western; Cerebrovascular Circul | 2003 |
Uncontrolled hypertension, uncompensated type II diabetes, and smoking have different patterns of vascular dysfunction.
Topics: Adult; Blood Flow Velocity; Cyclic GMP; Diabetes Mellitus, Type 2; Endothelium, Vascular; Humans; Hy | 2004 |
Persistent endothelial dysfunction is related to elevated C-reactive protein (CRP) levels in Type II diabetic patients after acute myocardial infarction.
Topics: Adiponectin; Aged; Brachial Artery; C-Reactive Protein; Cholesterol; Diabetes Mellitus, Type 2; Diab | 2005 |
Keeping track of the patch: transdermal delivery in obese patients.
Topics: Administration, Cutaneous; Angina Pectoris; Diabetes Mellitus, Type 2; Female; Humans; Middle Aged; | 2005 |
Indication of long-term endothelial dysfunction after sirolimus-eluting stent implantation.
Topics: Aged; Coronary Angiography; Coronary Restenosis; Coronary Vasospasm; Diabetes Mellitus, Type 2; Diab | 2006 |
Platelet nitrate responsiveness in fasting and postprandial type 2 diabetes.
Topics: Adenosine Diphosphate; Adult; Aged; Blood Platelets; Brachial Artery; Diabetes Mellitus, Type 2; Fas | 2005 |
Vascular defect beyond the endothelium in type II diabetic patients with overt nephropathy and moderate renal insufficiency.
Topics: Aged; Brachial Artery; Carotid Arteries; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic A | 2006 |
Association between insulin resistance and endothelial dysfunction in type 2 diabetes and the effects of pioglitazone.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Humans; Hypogl | 2007 |
Chronic kidney disease--a disease domain complex.
Topics: Aged; Alendronate; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Asp | 2008 |
Impaired flow-mediated vasodilation in type 2 diabetes: lack of relation to microvascular dysfunction.
Topics: Aged; Aged, 80 and over; Blood Flow Velocity; Brachial Artery; Diabetes Mellitus, Type 2; Endotheliu | 2008 |
Abnormal rheologic effects of glyceryl trinitrate in patients with non-insulin-dependent diabetes mellitus and reversal by antioxidants.
Topics: Adult; Aged; Blood Pressure; Blood Viscosity; Case-Control Studies; Diabetes Mellitus, Type 2; Femal | 1995 |
[The functional dynamics of capillary blood flow in patients with IHD combined with diabetes mellitus].
Topics: Angina, Unstable; Angiography, Digital Subtraction; Capillaries; Conjunctiva; Diabetes Mellitus, Typ | 1994 |
Primary nitrate tolerance in diabetes mellitus.
Topics: Acetylcholine; Arterioles; Diabetes Mellitus, Type 2; Drug Tolerance; Endothelium, Vascular; Forearm | 1994 |
Impaired arterial but not venous responsiveness to nitroglycerin in non-insulin-dependent diabetes mellitus.
Topics: Aorta; Arteries; Blood Pressure; Carotid Arteries; Diabetes Mellitus, Type 2; Female; Femoral Artery | 1997 |
Platelet resistance to nitrates in obesity and obese NIDDM, and normal platelet sensitivity to both insulin and nitrates in lean NIDDM.
Topics: Adenosine Diphosphate; Adult; Analysis of Variance; Blood Glucose; Blood Platelets; Blood Pressure; | 1998 |
Preserved endothelial function in IDDM patients, but not in NIDDM patients, compared with healthy subjects.
Topics: Adult; Blood Flow Velocity; Brachial Artery; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; E | 1998 |
Impaired beta-adrenoceptor mediated venodilation in patients with diabetes mellitus.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Glyburide; Humans; Isoproterenol; Male; Middle Aged; Nitrogl | 1999 |
Influence of low density lipoprotein (LDL) subfraction profile and LDL oxidation on endothelium-dependent and independent vasodilation in patients with type 2 diabetes.
Topics: Adult; Brachial Artery; Centrifugation, Density Gradient; Cholesterol; Copper; Diabetes Mellitus, Ty | 1999 |
Coronary artery distensibility in diabetic patients with simultaneous measurements of luminal area and intracoronary pressure: evidence of impaired reactivity to nitroglycerin.
Topics: Adult; Aged; Blood Pressure; Cardiac Catheterization; Coronary Disease; Coronary Vessels; Diabetes M | 1999 |
Endothelial dysfunction in Type 2 diabetic subjects with and without microalbuminuria.
Topics: Adult; Albuminuria; Brachial Artery; Cholesterol, HDL; Diabetes Mellitus, Type 2; Endothelium, Vascu | 1999 |
Duplex sonographic registration of age and diabetes-related loss of renal vasodilatory response to nitroglycerine.
Topics: Adult; Aged; Aged, 80 and over; Aging; Arterioles; Diabetes Mellitus, Type 1; Diabetes Mellitus, Typ | 2000 |
Pseudonormal diastolic filling unmasked with glyceryl trinitrate in patients with type 2 diabetes with poor metabolic control.
Topics: Biomarkers; Blood Glucose; Body Surface Area; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diastole | 2001 |
Interaction of hypertension and diabetes on impairment of endothelial function.
Topics: Aged; Brachial Artery; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Endothelium, Vas | 2001 |
Shedding of TNF-alpha receptors, blood pressure, and insulin sensitivity in type 2 diabetes mellitus.
Topics: Adult; Aged; Antigens, CD; Blood Pressure; Body Mass Index; Diabetes Mellitus, Type 1; Diabetes Mell | 2002 |
Smoking and proteinuria impair vasodilatory response of intrarenal arteries to nitroglycerine in patients with type 2 diabetes mellitus.
Topics: Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Nitroglycerin; Proteinuria; Regression | 2002 |
Impaired vascular reactivity is present despite normal levels of von Willebrand factor in patients with uncomplicated Type 2 diabetes.
Topics: Albuminuria; Blood Pressure; Body Mass Index; Cardiovascular Diseases; Cholesterol; Diabetes Mellitu | 2002 |
Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus.
Topics: Acetylcholine; Analysis of Variance; Arginine; Diabetes Mellitus, Type 2; Endothelium, Vascular; Fem | 1992 |
[Changes in the rate of surface blood microcirculation studied by photon-correlation spectroscopy in the practical treatment and diagnosis of diabetes mellitus].
Topics: Adolescent; Adult; Aged; Blood Flow Velocity; Conjunctiva; Diabetes Mellitus, Type 1; Diabetes Melli | 1985 |