Page last updated: 2024-11-01

nitroglycerin and Coronary Thrombosis

nitroglycerin has been researched along with Coronary Thrombosis in 19 studies

Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.

Coronary Thrombosis: Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"Neonatal myocardial infarction is rare and is associated with a high mortality of 40% to 50%."2.82Neonatal Myocardial Infarction: A Proposed Algorithm for Coronary Arterial Thrombus Management. ( El-Sabrout, H; El-Said, H; Ganta, S; Guyon, P; Hegde, S; Kimball, A; Mo, J; Nigro, J; Perry, J; Ratnayaka, K; Ryan, J; Thornburg, CD; Tucker, S; Vaughn, G, 2022)
" Because the effects of long-term smoking are multifactorial, a rabbit model was made by chronic administration of buthionine sulfoximine (BSO, n=6) to decrease intraplatelet GSH."1.31Long-term smoking causes nitroglycerin resistance in platelets by depletion of intraplatelet glutathione. ( Haramaki, N; Haramaki, R; Ikeda, H; Imaizumi, T; Kanaya, S; Katoh, A; Murohara, T; Shintani, S; Takajo, Y, 2001)
" Lack of any significant effect of therapeutic dosage of glyceryl trinitrate on platelet--fibrin rich thrombus may explain the absence of a salutary action of this agent."1.28Pathological basis of failure of concurrent glyceryl trinitrate therapy to improve efficacy of tissue type plasminogen activator in coronary thrombosis. ( Mehta, JL; Nichols, WW; Nicolini, FA; Saldeen, TG, 1991)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19904 (21.05)18.7374
1990's9 (47.37)18.2507
2000's3 (15.79)29.6817
2010's2 (10.53)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
El-Sabrout, H1
Ganta, S1
Guyon, P1
Ratnayaka, K1
Vaughn, G1
Perry, J1
Kimball, A1
Ryan, J1
Thornburg, CD1
Tucker, S1
Mo, J1
Hegde, S1
Nigro, J1
El-Said, H1
Wang, K1
Zhang, J1
Zhang, N1
Shen, Y1
Wang, L1
Gu, R1
Xu, B1
Ji, Y1
Essandoh, MK1
Dalia, AA1
George, BS1
Flores, AS1
Otey, AJ1
Kirtane, AJ1
Broderick, TM1
Rao, SV1
Sezgin, AT1
Sigirci, A1
Barutcu, I1
Topal, E1
Sezgin, N1
Ozdemir, R1
Yetkin, E1
Tandogan, I1
Kosar, F1
Ermis, N1
Yologlu, S1
Bariskaner, E1
Cehreli, S1
STERN, ML1
Schulman, SP1
Kern, MJ1
Caracciolo, EA1
Aguirre, FV1
Bach, RG1
Donohue, TJ1
Fleck, E1
Auch-Schwelk, W1
Frantz, E1
Krackhardt, F1
Oswald, H1
Sauer, HU1
Akiyama, H1
Ishikawa, K1
Kanamasa, K1
Ogawa, I1
Koka, H1
Kamata, N1
Nakai, S1
Katori, R1
Haramaki, N1
Ikeda, H1
Takajo, Y1
Katoh, A1
Kanaya, S1
Shintani, S1
Haramaki, R1
Murohara, T1
Imaizumi, T1
Adachi, H1
Fujimori, T1
Shoji, T1
Rösen, R1
Bernards, W1
Jumpertz, K1
Kreie, KJ1
Wiesmüller, G1
Klaus, W1
Nicolini, FA1
Nichols, WW1
Saldeen, TG1
Mehta, JL1
Verna, E1
Repetto, S1
Boscarini, M1
Onofri, M1
Qing, LG1
Binaghi, G1
Chikvashvili, DI1
Rado, Iu1
Staroverov, II1
Ruda, MIa1
Park, SE1
Tani, A1
Minamino, T1
Azuma, J1
Kishimoto, S1
Buonanno, C1
Shtern, SV1
Labunskiĭ, VIu1
Bezrukova, GA1
Shvarts, IL1
Kotel'nikov, EV1
Tomoda, H1
Yokota, I1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized, Double-Blind, Active-Controlled, Multicenter Trial of Abciximab And Bivalirudin in Patients With Non-ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Interventions (ISAR-REACT-4)[NCT00373451]Phase 41,721 participants (Actual)Interventional2006-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for nitroglycerin and Coronary Thrombosis

ArticleYear
Neonatal Myocardial Infarction: A Proposed Algorithm for Coronary Arterial Thrombus Management.
    Circulation. Cardiovascular interventions, 2022, Volume: 15, Issue:5

    Topics: Algorithms; Coronary Thrombosis; Coronary Vessels; Heparin; Humans; Infant; Infant, Newborn; Mitral

2022
[Diagnosis of the dynamic lesion].
    Zeitschrift fur Kardiologie, 1993, Volume: 82 Suppl 5

    Topics: Acetylcholine; Angina Pectoris, Variant; Angina, Unstable; Coronary Angiography; Coronary Artery Dis

1993

Trials

2 trials available for nitroglycerin and Coronary Thrombosis

ArticleYear
Combined Primary PCI with Multiple Thrombus Burden Reduction Therapy Improved Cardiac Function in Patients with Acute Anterior Myocardial Infarction.
    International heart journal, 2019, Jan-25, Volume: 60, Issue:1

    Topics: Adult; Aged; Anterior Wall Myocardial Infarction; Combined Modality Therapy; Coronary Thrombosis; Fe

2019
[Effect of thrombolytic, anticoagulant and anti-thrombocytic therapy on the development of left-ventricular thrombosis and the incidence of thromboembolic complications in patients with myocardial infarction].
    Kardiologiia, 1990, Volume: 30, Issue:4

    Topics: Blood Coagulation; Coronary Disease; Coronary Thrombosis; Drug Therapy, Combination; Heparin; Humans

1990

Other Studies

15 other studies available for nitroglycerin and Coronary Thrombosis

ArticleYear
CASE 11-2016 Perioperative Coronary Thrombosis in a Patient With Multiple Second-Generation Drug-Eluting Stents: Is It Time for a Paradigm Shift?
    Journal of cardiothoracic and vascular anesthesia, 2016, Volume: 30, Issue:6

    Topics: Analgesics, Opioid; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clopid

2016
Vascular endothelial function in patients with slow coronary flow.
    Coronary artery disease, 2003, Volume: 14, Issue:2

    Topics: Adult; Blood Flow Velocity; Brachial Artery; Coronary Angiography; Coronary Artery Disease; Coronary

2003
PREVENTION OF CORONARY THROMBOSIS: CLINICAL OBSERVATIONS FOR 1 TO 10 YEARS.
    Current therapeutic research, clinical and experimental, 1965, Volume: 7

    Topics: Biomedical Research; Coronary Disease; Coronary Thrombosis; Drug Therapy; Humans; Niacin; Nicotinic

1965
Antiplatelet therapy in non-ST-segment elevation acute coronary syndromes.
    JAMA, 2004, Oct-20, Volume: 292, Issue:15

    Topics: Adrenergic beta-Antagonists; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery B

2004
Alterations of coronary flow velocity during intervention for acute myocardial infarction: responses to complications of intracoronary thrombolysis and angioplasty.
    Catheterization and cardiovascular diagnosis, 1994, Volume: 32, Issue:3

    Topics: Angioplasty, Balloon, Coronary; Coronary Angiography; Coronary Circulation; Coronary Thrombosis; Cor

1994
Increased coronary vasomotor tone in acute myocardial infarction patients with spontaneous coronary recanalization.
    Japanese circulation journal, 1997, Volume: 61, Issue:6

    Topics: Adult; Aged; Angina Pectoris; Coronary Angiography; Coronary Circulation; Coronary Thrombosis; Coron

1997
Long-term smoking causes nitroglycerin resistance in platelets by depletion of intraplatelet glutathione.
    Arteriosclerosis, thrombosis, and vascular biology, 2001, Volume: 21, Issue:11

    Topics: Animals; Blood Platelets; Buthionine Sulfoximine; Coronary Thrombosis; Cyclic GMP; Female; Glutathio

2001
Inhibitory effects of a novel antiplatelet aggregating agent, E-5510, on cyclic flow variations in electrically stimulated coronary arteries of the pig.
    Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:5

    Topics: Animals; Coronary Circulation; Coronary Thrombosis; Electric Stimulation; Electrocardiography; Fatty

1990
[Interaction between thrombocytes and the coronary system in the presence of SIN 1 and nitroglycerin after endothelial damage].
    Zeitschrift fur Kardiologie, 1991, Volume: 80 Suppl 5

    Topics: Animals; Blood Platelets; Coronary Circulation; Coronary Thrombosis; Endothelium, Vascular; Models,

1991
Pathological basis of failure of concurrent glyceryl trinitrate therapy to improve efficacy of tissue type plasminogen activator in coronary thrombosis.
    Cardiovascular research, 1991, Volume: 25, Issue:4

    Topics: Animals; Blood Pressure; Coronary Thrombosis; Coronary Vessels; Dogs; Drug Therapy, Combination; Hea

1991
Management of complicated coronary angioplasty by intracoronary urokinase and immediate re-angioplasty.
    Catheterization and cardiovascular diagnosis, 1990, Volume: 19, Issue:2

    Topics: Angioplasty, Balloon, Coronary; Coronary Angiography; Coronary Disease; Coronary Thrombosis; Female;

1990
Coronary angiographic features within 48 hours from onset of non-Q wave myocardial infarction with R wave regression and no ST segment depression.
    Cardiology, 1990, Volume: 77, Issue:2

    Topics: Coronary Angiography; Coronary Thrombosis; Coronary Vasospasm; Creatine Kinase; Electrocardiography;

1990
[Acute coronary occlusion during transluminal angioplasty: role of coronary thrombosis].
    Giornale italiano di cardiologia, 1988, Volume: 18, Issue:6

    Topics: Aged; Angiography; Angioplasty, Balloon; Coronary Angiography; Coronary Disease; Coronary Thrombosis

1988
[Factors contributing to the success of intracoronary thrombolytic therapy].
    Kardiologiia, 1987, Volume: 27, Issue:10

    Topics: Adult; Age Factors; Aged; Bayes Theorem; Coronary Disease; Coronary Thrombosis; Female; Hemodynamics

1987
Intracoronary thrombodynamics in the early phase of acute myocardial infarction.
    Japanese circulation journal, 1988, Volume: 52, Issue:7

    Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Disease; Coronary Thrombosis; Death, Sudden;

1988