nitroglycerin has been researched along with Chronic Disease in 313 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to determine the optimal dose and dosing interval of nitroglycerin ointment to heal chronic anal fissures." | 10.20 | A study to determine the nitroglycerin ointment dose and dosing interval that best promote the healing of chronic anal fissures. ( Bailey, HR; Beck, DE; Billingham, RP; Binderow, SR; Gibbons, RD; Gottesman, L; Hull, TL; Larach, SW; Margolin, DA; Milsom, JW; Potenti, FM; Rafferty, JF; Riff, DS; Sands, LR; Senagore, A; Stamos, MJ; Yee, LF; Young-Fadok, TM, 2002) |
| "2% nitroglycerin ointment for the treatment of chronic anal fissure." | 9.19 | Internal sphincterotomy versus topical nitroglycerin ointment for chronic anal fissure. ( Aslam, MI; Figueiredo, R; Pervaiz, A, 2014) |
| "To compare the symptomatic relief, healing and side-effects of topical diltiazem (DTZ) and glyceryl trinitrate in the treatment of chronic anal fissure." | 9.14 | Topical diltiazem hydrochloride and glyceryl trinitrate in the treatment of chronic anal fissure. ( Jawaid, M; Masood, Z; Salim, M, 2009) |
| "To evaluate the efficacy and safety of botulinum toxin A injection compared with topical nitroglycerin ointment for the treatment of chronic anal fissure (CAF)." | 9.12 | Efficacy and safety of botulinum toxin a injection compared with topical nitroglycerin ointment for the treatment of chronic anal fissure: a prospective randomized study. ( Bauerfeind, P; Fried, M; Fruehauf, H; Thumshirn, M; Wegmueller, B, 2006) |
| "Although treatment with either topical nitroglycerin or botulinum toxin is effective as an alternative to surgery for patients with chronic anal fissure, botulinum toxin is the more effective option." | 9.12 | Randomized clinical trial comparing botulinum toxin injections with 0.2 per cent nitroglycerin ointment for chronic anal fissure. ( Brandara, F; Brisinda, G; Cadeddu, F; Maria, G; Marniga, G, 2007) |
| "After six years of follow-up, it seems that lateral internal sphincterotomy is a more durable treatment for chronic anal fissure compared with topical nitroglycerin therapy and does not compromise long-term fecal continence." | 9.12 | Lateral internal sphincterotomy is superior to topical nitroglycerin for healing chronic anal fissure and does not compromise long-term fecal continence: six-year follow-up of a multicenter, randomized, controlled trial. ( Brown, CJ; Dubreuil, D; Liu, M; McLeod, RS; O'Connor, BI; Santoro, L, 2007) |
| "The aim of this study was to compare prospectively diltiazem with GTN ointment in the treatment of anal fissure." | 9.10 | A prospective randomized trial of diltiazem and glyceryltrinitrate ointment in the treatment of chronic anal fissure. ( Bielecki, K; Kolodziejczak, M, 2003) |
| "Although treatment with either topical nitroglycerin or botulinum toxin is effective as an alternative to surgery for patients with chronic anal fissure, botulinum toxin is the more effective nonsurgical treatment." | 9.09 | A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. ( Albanese, A; Bentivoglio, AR; Brisinda, G; Cassetta, E; Gui, D; Maria, G, 1999) |
| "We sought to determine the effect of aspirin on the venodilator effect of furosemide in patients with chronic heart failure (CHF) BACKGROUND: Furosemide has an acute venodilator effect preceding its diuretic action, which is blocked by nonsteroidal anti-inflammatory, drugs." | 9.09 | Aspirin inhibits the acute venodilator response to furosemide in patients with chronic heart failure. ( Davie, AP; Jhund, PS; McMurray, JJ, 2001) |
| "Topical application of nitroglycerine represents a new, easily handled, and effective alternative in the treatment of anal fissures." | 9.08 | Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy? ( Bacher, H; Cerwenka, H; El-Shabrawi, A; Mischinger, HJ; Pfeifer, J; Schweiger, W; Werkgartner, G, 1997) |
| "This study was designed to investigate the effect of angiotensin-converting enzyme (ACE) inhibitors with and without a sulfhydryl group on intracellular production of cGMP, forearm blood flow, and neurohormonal factors during continuous transdermal application of nitroglycerin in patients with chronic heart failure." | 9.08 | Preventive effects of angiotensin-converting enzyme inhibitors on nitrate tolerance during continuous transdermal application of nitroglycerin in patients with chronic heart failure. ( Kakihana, M; Ohtsuka, S; Sugishita, Y; Watanabe, H, 1998) |
| "This study was designed to assess the efficacy, tolerability, and safety of mibefradil when added to long-acting nitrate therapy in patients with chronic stable angina pectoris." | 9.08 | Additional antianginal and anti-ischemic efficacy of mibefradil in patients concomitantly treated with long-acting nitrates for chronic stable angina pectoris. ( Bittar, N; Frishman, WH; Glasser, S; Habib, G; Pordy, R; Smith, W, 1998) |
| "This study was designed to evaluate the effect of carvedilol on nitrate tolerance in patients with chronic heart failure." | 9.08 | Randomized, double-blind, placebo-controlled study of carvedilol on the prevention of nitrate tolerance in patients with chronic heart failure. ( Kakihana, M; Ohtsuka, S; Sugishita, Y; Watanabe, H, 1998) |
| "We have previously shown that transdermal nitroglycerin may induce an increase in the activity of the adrenergic and the renin-angiotensin-aldosterone systems (SRAA) in patients with chronic stable angina pectoris (SA); when the activation of these systems is more pronounced, the antianginal effect of this drug seems to be reduced." | 9.07 | Effects of transdermal nitroglycerin in combination with an ACE inhibitor in patients with chronic stable angina pectoris. ( Agabiti-Rosei, E; Beschi, M; Boni, E; Castellano, M; Cefis, G; Cerri, B; Muiesan, ML; Pollavini, G; Porcellati, C; Verdecchia, P, 1993) |
| "The aim of this study was to evaluate the acute effects of transdermal nitroglycerin on the sympathetic and renin-angiotensin-aldosterone systems activity, in a group of patients with stable exercise induced angina pectoris." | 9.07 | Transdermal nitroglycerin efficacy in patients with chronic stable angina pectoris as related to sympathetic and renin-angiotensin-aldosterone activity. ( Agabiti-Rosei, E; Beschi, M; Castellano, M; Cefis, M; Cerri, B; Muiesan, G; Muiesan, ML; Pollavini, G; Romanelli, G, 1992) |
| "The efficacy of transdermal nitroglycerin patches, releasing 20 mg of active substance over a period of 24 h (TDN 20), was investigated in 10 patients with stable exercise-induced angina pectoris." | 9.06 | Chronic effects of transdermal nitroglycerin in stable angina pectoris: a within-patient, placebo-controlled study. ( Bruno, AM; Corti, D; De Ponti, C; Fiorini, GL; Gibelli, G; Lambiase, M; Magenta, G; Negrini, M; Pollavini, PG; Prina, L, 1989) |
| "Twenty-two patients with chronic, stable, exercise-induced angina pectoris were assessed during periods of therapy with propranolol, standard-formulation pindolol, and a slow-release preparation of pindolol." | 9.05 | Comparison of slow-release pindolol, standard pindolol, and propranolol in angina pectoris. ( Parker, JO, 1983) |
| "The effects of coenzyme Q10(CoQ10) on exercise performance were studied in 12 patients, average age 56 years, with stable angina pectoris." | 9.05 | Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. ( Hayashi, H; Kamikawa, T; Kobayashi, A; Yamashita, T; Yamazaki, N, 1985) |
| "The study analyzed clinical trials investigating the effectiveness of diltiazem (DTZ) and glyceryltrinitrate (GTN) for the nonsurgical management of chronic anal fissure (CAF)." | 8.89 | Systematic review of the use of topical diltiazem compared with glyceryltrinitrate for the nonoperative management of chronic anal fissure. ( Baig, MK; Sains, P; Sajid, MS; Whitehouse, PA, 2013) |
| "The objective of this review is to systematically analyze the prospective randomized controlled trials on the effectiveness of diltiazem (DTZ) and glyceryltrinitrate (GTN) for the pharmacological management of chronic anal fissure (CAF)." | 8.84 | The efficacy of diltiazem and glyceryltrinitrate for the medical management of chronic anal fissure: a meta-analysis. ( Baig, MK; Cheek, E; Rimple, J; Sajid, MS, 2008) |
| "4% Nitroglycerin ointment is an intra-anal formulation of nitroglycerin (glyceryl trinitrate) indicated for the treatment of chronic anal fissure pain." | 8.83 | 0.4% nitroglycerin ointment : in the treatment of chronic anal fissure pain. ( Easthope, SE; Fenton, C; Wellington, K, 2006) |
| "This study explores the evidence-based background for treating chronic anal fissure with topically applied nitroglycerin (NTG): in part the general effect of NTG and in part how its effect compares to that of surgery, which has been claimed to have long-term complications like incontinence for flatus and faeces." | 8.81 | [Treatment of chronic anal fissure with topically applied nitroglycerin ointment. A systematic review of evidence-based results]. ( Matzen, P; Svendsen, CB, 2002) |
| " The authors describe their clinical practice during the last 15 years: nitrates with short half-life in the treatment of acute pancreatitis (amylnitrit or nitroglycerin spray) which have a low risk of developing nitrate tolerance; chronic administration of retard nitroglycerin in chronic pancreatitis and Oddi's sphincter hypertonic dyskinesia." | 8.78 | The role of nitroglycerin preparations in the treatment of post-acute and chronic pancreatitis. ( Berger, Z; Pap, A, 1993) |
| "Nitroglycerin and its derivatives have become widely used agents in the treatment of severe forms of heart failure." | 8.77 | [Use of nitroglycerin in the treatment of congestive heart failure]. ( Curyło, AM, 1989) |
| "The aim of this study was to investigate whether the neuropeptide calcitonin gene related peptide (CGRP) contributes to nitroglycerin (GTN) response in patients with chronic heart failure (CHF) and the association with the mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys (ALDH2*2) polymorphism." | 7.78 | Influence of ALDH2 Glu504Lys polymorphism on nitroglycerin response in chronic heart failure and involvement of Calcitonin Gene Related Peptide (CGRP). ( Chen, XP; Guo, YJ; Li, CC; Li, L; Li, YJ; Mo, L; Peng, LM; Sun, J; Xie, W; Yang, TL, 2012) |
| "Nitroglycerin dose-dependently increases tissue perfusion in patients with severe heart failure, as observed by a decrease in central-peripheral temperature gradient and an increase in sublingual perfused capillary density." | 7.75 | Dose-dependent benefit of nitroglycerin on microcirculation of patients with severe heart failure. ( Caliskan, K; den Uil, CA; Jewbali, LS; Lagrand, WK; Simoons, ML; Spronk, PE; van der Ent, M; van Kuijk, JP, 2009) |
| "2% glycerl trinitrate (GTN) and topical 2% diltiazem (DTZ), in the management of chronic anal fissure." | 7.75 | Diltiazem (2%) versus glyceryl trinitrate cream (0.2%) in the management of chronic anal fissure. ( Hashmi, F; Siddiqui, FG, 2009) |
| "Patients with chronic heart failure (CHF) often require higher doses of nitroglycerin (glyceryl trinitrate, GTN) than patients with normal cardiac function to achieve a given haemodynamic goal." | 7.74 | Impaired nitroglycerin biotransformation in patients with chronic heart failure. ( Adams, MA; Bennett, BM; Friberg, P; Petersson, M; Rundqvist, B, 2008) |
| "Both topical diltiazem, a calcium channel blocker, and glyceryl trinitrate, a nitric oxide donor, lower anal pressure and heal two-thirds of chronic anal fissures." | 7.71 | Diltiazem heals glyceryl trinitrate-resistant chronic anal fissures: a prospective study. ( Jonas, M; Scholefield, JH; Speake, W, 2002) |
| " Systemic administration of nitroglycerin (NTG) or mild hypoxia resulted in a decreased of c-fos expression in the dorsolateral part of the denervated neostriatum." | 7.71 | Fos and nitric oxide synthase in rat brain with chronic mesostriatal dopamine deficiency: effects of nitroglycerin and hypoxia. ( Appenzeller, O; Bazilyuk, OV; Maisky, VA; Oleshko, NN; Sagach, VF; Talanov, SA, 2002) |
| "Topical nitroglycerin was only effective in approximately one-half of patients with an anal fissure." | 7.70 | Nitroglycerin ointment for anal fissures: effective treatment or just a headache? ( Cataldo, PA; Hyman, NH, 1999) |
| "This study was designed to determine the efficacy of L-arginine in healing of gastric ulcers induced by acetic acid and to assess the role of nitric oxide (NO), prostaglandins, gastrin and polyamines in the healing process." | 7.69 | Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide, prostaglandins, gastrin and polyamines. ( Brzozowski, T; Dembiński, A; Drozdowicz, D; Konturek, SJ; Stachura, J, 1995) |
| "The goal of this study was to determine the role of prostaglandin H2-thromboxane A2 (PGH2-TxA2) in altered responses of cerebral arterioles during chronic hypertension." | 7.68 | Role of prostaglandin H2-thromboxane A2 in responses of cerebral arterioles during chronic hypertension. ( Mayhan, WG, 1992) |
| "The effects of single, consecutively increased, oral doses of the beta-adrenoceptor antagonist bisoprolol (5, 10, 15, 20, 30 and 40 mg) on blood pressure, heart rate and bronchomotor tone were investigated in an open acute trial with 16 patients suffering from angina pectoris due to coronary heart disease and reversible chronic obstructive bronchitis." | 7.67 | Dose-response relationship of the beta-adrenoceptor antagonist bisoprolol in patients with coronary heart disease and chronic obstructive bronchitis. ( Dorow, P; Tönnesmann, U, 1984) |
| "Kinetocardiography and integral rheography of the body were used to examine the effect of nitroglycerin on the hemodynamics in 17 patients with chronic obstructive bronchitis complicated by pulmonary hypertension." | 7.67 | [Effect of nitroglycerin on various indicators of hemodynamics in patients with chronic obstructive bronchitis complicated by pulmonary hypertension]. ( Aleksandrov, AL; Cherniakova, TG; Matkovskii, SK, 1985) |
| "The hemodynamic and hormonal responses to nitroglycerin administered transdermally in a gel-like matrix were evaluated in nine patients with severe congestive heart failure and in nine normal subjects." | 7.66 | Hemodynamic and hormonal response to transdermal nitroglycerin in normal subjects and in patients with congestive heart failure. ( Carlyle, PF; Cohn, JN; Levine, TB; Olivari, MT, 1983) |
| " Hemodynamic effects o high doses of oral isosorbide dinitrate in patients with chronic heart failure (N - 13)." | 7.66 | Hemodynamic effects of nitrates in chronic heart failure and myocardial infarction. ( Chatterjee, K, 1980) |
| "The hemodynamic effects of nitroglycerin absorbed transcutaneously from an ointment base were determined in 10 patients with chronic congestive heart failure (9 with ischemic heart disease and 1 with cardiomyopathy)." | 7.65 | Hemodynamic effects of nitroglycerin ointment in congestive heart failure. ( Chatterjee, K; Forrester, JS; Magnusson, P; Swan, HJ; Takano, T; Taylor, WR, 1976) |
| "Diltiazem gel was found to be superior to Glyceril trinitrate ointment due to significantly higher healing rate and fewer side-effects." | 6.77 | Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double-blind trial. ( Ala, S; Ghorbanian, A; Hadianamrei, R; Saeedi, M, 2012) |
| "Diltiazem ointment was found to be superior regarding pain relief, fewer side effects, and late recurrence as compared with GTN ointment." | 6.73 | A comparison of the effects of diltiazem and glyceryl trinitrate ointment in the treatment of chronic anal fissure: a randomized clinical trial. ( Jain, BK; Kumar, P; Saifee, Y; Shrivastava, UK, 2007) |
| "Nitroglycerin or placebo was administered in two daily applications for two weeks." | 6.70 | Long-term results of topical nitroglycerin in the treatment of chronic anal fissures are disappointing. ( Bisisio, O; Graziano, A; Gualdrini, U; Lencinas, S; Masciangioli, G; Svidler López, L, 2001) |
| "Mibefradil-treated patients showed greater decreases in heart rate and the rate-pressure product at each stage of the ETT than patients treated with amlodipine or diltiazem SR." | 6.68 | Mibefradil in the treatment of chronic stable angina pectoris: comparative studies with other calcium antagonists. ( Davies, GJ; Kobrin, I; Tzivoni, D, 1997) |
| " However, 2 h after dosing there was a significant prolongation during stress testing in the time to onset of both 1 mm ST depression on the ECG (by 28%) and to angina (by 37%) compared with atenolol alone, but no benefit was apparent by 12 h after dosing." | 6.66 | Slow release nifedipine plus atenolol in chronic stable angina pectoris. ( Challenor, VF; George, CF; Renwick, AG; Waller, DG, 1989) |
| "Nisoldipine is a second-generation dihydropyridine calcium antagonist that has been extensively studied as an antianginal and antihypertensive agent." | 6.39 | Nisoldipine coat core as concomitant therapy in chronic stable angina pectoris. ( Glasser, SP, 1995) |
| "The aim of this study was to determine the optimal dose and dosing interval of nitroglycerin ointment to heal chronic anal fissures." | 6.20 | A study to determine the nitroglycerin ointment dose and dosing interval that best promote the healing of chronic anal fissures. ( Bailey, HR; Beck, DE; Billingham, RP; Binderow, SR; Gibbons, RD; Gottesman, L; Hull, TL; Larach, SW; Margolin, DA; Milsom, JW; Potenti, FM; Rafferty, JF; Riff, DS; Sands, LR; Senagore, A; Stamos, MJ; Yee, LF; Young-Fadok, TM, 2002) |
| "Treatment with sarpogrelate significantly increased the SAS score and prolonged exercise time to the onset of 0." | 5.31 | Effectiveness of a novel serotonin blocker, sarpogrelate, for patients with angina pectoris. ( Fujita, M; Hanada, H; Kinugawa, T; Lee, JD; Miyamoto, S; Nakajima, H, 2002) |
| " A fortnight nitrogen regimen in a dosage of 2." | 5.28 | [Effect of nitroglycerin preparations on indicators of central hemodynamics in patients with pulmonary tuberculosis complicated by chronic cor pulmonale]. ( Mar'iandyshev, AO, 1990) |
| "In all 20 patients, ventricular arrhythmias were consistently present during both tests on placebo, that were markedly reduced by nitroglycerin." | 5.28 | [Intravenous nitroglycerin infusion suppresses exercise-induced arrhythmia in patients with ischemic cardiopathy: indications for chronic treatment ]. ( Bonetti, F; Chierchia, SL; Cianflone, D; Mailhac, A; Margonato, A; Scarpazza, P; Vicedomini, G, 1990) |
| "Captopril is a mixed vasodilator and is effective from the first hour of administration." | 5.27 | [Enhancement of the effect of captopril in the 1st 48 hours of treating refractory heart failure. A comparison with intravenous trinitrine]. ( Baubion, N; Di Matteo, J; Heulin, A; Le Pailleur, C; Metzger, JP; Vacheron, A, 1984) |
| "To determine whether the medical Treatment of anal fissure can be an effective alternative for surgery Methods: Retrospectively, we randomly selected 190 Patients being treated for anal fissure between the years 2005-2010 in 3 equal groups: group A: Patients who received medical treatment with topical nitroglycerin, group B: Patient treated with topical diltiazem, and group C: Patients underwent surgery." | 5.22 | Chronic Anal Fissure: A Comparative Study of Medical Treatment Versus Surgical Sphincterotomy. ( Hashemi, P; Motie, MR, 2016) |
| "2% nitroglycerin ointment for the treatment of chronic anal fissure." | 5.19 | Internal sphincterotomy versus topical nitroglycerin ointment for chronic anal fissure. ( Aslam, MI; Figueiredo, R; Pervaiz, A, 2014) |
| "Application of nitroglycerin (glyceryl trinitrate) ointment with perianal administration is a widely used treatment for chronic anal fissure." | 5.16 | Perianal versus endoanal application of glyceryl trinitrate 0.4% ointment in the treatment of chronic anal fissure: results of a randomized controlled trial. Is this the solution to the headaches? ( Arroyo, A; Calpena, R; Candela, F; Frangi, A; Moya, P; Oliver, MI; Pérez-Legaz, J; Ruiz-Tovar, J, 2012) |
| "To compare the symptomatic relief, healing and side-effects of topical diltiazem (DTZ) and glyceryl trinitrate in the treatment of chronic anal fissure." | 5.14 | Topical diltiazem hydrochloride and glyceryl trinitrate in the treatment of chronic anal fissure. ( Jawaid, M; Masood, Z; Salim, M, 2009) |
| "To evaluate the efficacy and safety of botulinum toxin A injection compared with topical nitroglycerin ointment for the treatment of chronic anal fissure (CAF)." | 5.12 | Efficacy and safety of botulinum toxin a injection compared with topical nitroglycerin ointment for the treatment of chronic anal fissure: a prospective randomized study. ( Bauerfeind, P; Fried, M; Fruehauf, H; Thumshirn, M; Wegmueller, B, 2006) |
| "Stable patients with coronary disease and > or =3 anginal attacks per week despite maximum recommended dosage of amlodipine (10 mg/day) were randomized to 1,000 mg ranolazine or placebo twice a day for 6 weeks." | 5.12 | Antianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (Efficacy of Ranolazine in Chronic Angina) trial. ( Blokhin, A; Gratsiansky, NA; Huang, IZ; Meng, L; Stone, PH, 2006) |
| "Although treatment with either topical nitroglycerin or botulinum toxin is effective as an alternative to surgery for patients with chronic anal fissure, botulinum toxin is the more effective option." | 5.12 | Randomized clinical trial comparing botulinum toxin injections with 0.2 per cent nitroglycerin ointment for chronic anal fissure. ( Brandara, F; Brisinda, G; Cadeddu, F; Maria, G; Marniga, G, 2007) |
| "After six years of follow-up, it seems that lateral internal sphincterotomy is a more durable treatment for chronic anal fissure compared with topical nitroglycerin therapy and does not compromise long-term fecal continence." | 5.12 | Lateral internal sphincterotomy is superior to topical nitroglycerin for healing chronic anal fissure and does not compromise long-term fecal continence: six-year follow-up of a multicenter, randomized, controlled trial. ( Brown, CJ; Dubreuil, D; Liu, M; McLeod, RS; O'Connor, BI; Santoro, L, 2007) |
| "To determine whether, at trough levels, ranolazine improves the total exercise time of patients who have symptoms of chronic angina and who experience angina and ischemia at low workloads despite taking standard doses of atenolol, amlodipine, or diltiazem and to determine times to angina onset and to electrocardiographic evidence of myocardial ischemia, effect on angina attacks and nitroglycerin use, and effect on long-term survival in an open-label observational study extension." | 5.11 | Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial. ( Chaitman, BR; Chumakova, G; Kuch, J; Parker, JO; Pepine, CJ; Skettino, SL; Skopal, J; Wang, W; Wolff, AA, 2004) |
| "The aim of this study was to compare prospectively diltiazem with GTN ointment in the treatment of anal fissure." | 5.10 | A prospective randomized trial of diltiazem and glyceryltrinitrate ointment in the treatment of chronic anal fissure. ( Bielecki, K; Kolodziejczak, M, 2003) |
| "Although treatment with either topical nitroglycerin or botulinum toxin is effective as an alternative to surgery for patients with chronic anal fissure, botulinum toxin is the more effective nonsurgical treatment." | 5.09 | A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. ( Albanese, A; Bentivoglio, AR; Brisinda, G; Cassetta, E; Gui, D; Maria, G, 1999) |
| "Chronic heart failure (CHF) is associated with impaired endothelium-dependent vasodilation and increased basal vascular tone due, in part, to elevated endothelin-1 plasma levels." | 5.09 | Effects of endothelin a receptor blockade on endothelial function in patients with chronic heart failure. ( Berger, R; Frey, B; Heher, S; Hülsmann, M; Neunteufl, T; Pacher, R; Stanek, B, 2001) |
| "We sought to determine the effect of aspirin on the venodilator effect of furosemide in patients with chronic heart failure (CHF) BACKGROUND: Furosemide has an acute venodilator effect preceding its diuretic action, which is blocked by nonsteroidal anti-inflammatory, drugs." | 5.09 | Aspirin inhibits the acute venodilator response to furosemide in patients with chronic heart failure. ( Davie, AP; Jhund, PS; McMurray, JJ, 2001) |
| "Topical application of nitroglycerine represents a new, easily handled, and effective alternative in the treatment of anal fissures." | 5.08 | Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy? ( Bacher, H; Cerwenka, H; El-Shabrawi, A; Mischinger, HJ; Pfeifer, J; Schweiger, W; Werkgartner, G, 1997) |
| " Effectiveness of exogenic donator NO (transdermal nitroglycerine, Nitroderm NNS 5) was studied in a randomised trial of 76 gravidas with essential hypertension (EH), EH and chronic glomerulonephritis (GN)." | 5.08 | [Nitric oxide: its role in the development of pregnancy complications and in their prevention in women with hypertension and chronic glomerulonephritis]. ( Piatakova, NV; Rogov, VA; Tareeva, IE; Zozulia, OV, 1997) |
| "This study was designed to investigate the effect of angiotensin-converting enzyme (ACE) inhibitors with and without a sulfhydryl group on intracellular production of cGMP, forearm blood flow, and neurohormonal factors during continuous transdermal application of nitroglycerin in patients with chronic heart failure." | 5.08 | Preventive effects of angiotensin-converting enzyme inhibitors on nitrate tolerance during continuous transdermal application of nitroglycerin in patients with chronic heart failure. ( Kakihana, M; Ohtsuka, S; Sugishita, Y; Watanabe, H, 1998) |
| "This study was designed to assess the efficacy, tolerability, and safety of mibefradil when added to long-acting nitrate therapy in patients with chronic stable angina pectoris." | 5.08 | Additional antianginal and anti-ischemic efficacy of mibefradil in patients concomitantly treated with long-acting nitrates for chronic stable angina pectoris. ( Bittar, N; Frishman, WH; Glasser, S; Habib, G; Pordy, R; Smith, W, 1998) |
| "This study was designed to evaluate the effect of carvedilol on nitrate tolerance in patients with chronic heart failure." | 5.08 | Randomized, double-blind, placebo-controlled study of carvedilol on the prevention of nitrate tolerance in patients with chronic heart failure. ( Kakihana, M; Ohtsuka, S; Sugishita, Y; Watanabe, H, 1998) |
| "We have previously shown that transdermal nitroglycerin may induce an increase in the activity of the adrenergic and the renin-angiotensin-aldosterone systems (SRAA) in patients with chronic stable angina pectoris (SA); when the activation of these systems is more pronounced, the antianginal effect of this drug seems to be reduced." | 5.07 | Effects of transdermal nitroglycerin in combination with an ACE inhibitor in patients with chronic stable angina pectoris. ( Agabiti-Rosei, E; Beschi, M; Boni, E; Castellano, M; Cefis, G; Cerri, B; Muiesan, ML; Pollavini, G; Porcellati, C; Verdecchia, P, 1993) |
| "The present multicentre study, conducted in patients with angina pectoris on chronic therapy with continuous 24-hour transdermal nitroglycerin was aimed at investigating: (1) the actual incidence of nitrate tolerance; (2) the clinical features that characterize those who do not develop tolerance; (3) whether the evidence of clinical and ergometer benefits at 1-month assessment predicts their long-term maintenance." | 5.07 | [The development of tolerance to continuous transdermal nitroglycerin therapy in patients with angina of effort and mixed angina]. ( Bugiardini, R; Cianfrocca, C; Sabia, R; Zoboli, S, 1993) |
| "The aim of this study was to evaluate the acute effects of transdermal nitroglycerin on the sympathetic and renin-angiotensin-aldosterone systems activity, in a group of patients with stable exercise induced angina pectoris." | 5.07 | Transdermal nitroglycerin efficacy in patients with chronic stable angina pectoris as related to sympathetic and renin-angiotensin-aldosterone activity. ( Agabiti-Rosei, E; Beschi, M; Castellano, M; Cefis, M; Cerri, B; Muiesan, G; Muiesan, ML; Pollavini, G; Romanelli, G, 1992) |
| "The efficacy of transdermal nitroglycerin patches, releasing 20 mg of active substance over a period of 24 h (TDN 20), was investigated in 10 patients with stable exercise-induced angina pectoris." | 5.06 | Chronic effects of transdermal nitroglycerin in stable angina pectoris: a within-patient, placebo-controlled study. ( Bruno, AM; Corti, D; De Ponti, C; Fiorini, GL; Gibelli, G; Lambiase, M; Magenta, G; Negrini, M; Pollavini, PG; Prina, L, 1989) |
| "The effects of transdermal nitrate (TN) (Transiderm-Nitro TTS, Geigy Pharmaceuticals, one 10 cm2 patch daily) and oral isosorbide dinitrate (ISDN) (Sorbitrate, Stuart Pharmaceuticals, 10 mg three times daily) were compared in a group of 20 patients with chronic stable angina pectoris." | 5.06 | Comparison of transdermal nitrate and isosorbide dinitrate in chronic stable angina. ( Booth, K; Gleadhill, DN; Moles, K; Morton, P; Nicholls, DP; Rowan, J, 1986) |
| "Twenty-two patients with chronic, stable, exercise-induced angina pectoris were assessed during periods of therapy with propranolol, standard-formulation pindolol, and a slow-release preparation of pindolol." | 5.05 | Comparison of slow-release pindolol, standard pindolol, and propranolol in angina pectoris. ( Parker, JO, 1983) |
| "The effects of coenzyme Q10(CoQ10) on exercise performance were studied in 12 patients, average age 56 years, with stable angina pectoris." | 5.05 | Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. ( Hayashi, H; Kamikawa, T; Kobayashi, A; Yamashita, T; Yamazaki, N, 1985) |
| "The study analyzed clinical trials investigating the effectiveness of diltiazem (DTZ) and glyceryltrinitrate (GTN) for the nonsurgical management of chronic anal fissure (CAF)." | 4.89 | Systematic review of the use of topical diltiazem compared with glyceryltrinitrate for the nonoperative management of chronic anal fissure. ( Baig, MK; Sains, P; Sajid, MS; Whitehouse, PA, 2013) |
| "Ranolazine is a novel drug approved for the treatment of chronic angina pectoris." | 4.86 | Ranolazine: an anti-anginal drug with further therapeutic potential. ( Kloner, RA; Reffelmann, T, 2010) |
| "The objective of this review is to systematically analyze the prospective randomized controlled trials on the effectiveness of diltiazem (DTZ) and glyceryltrinitrate (GTN) for the pharmacological management of chronic anal fissure (CAF)." | 4.84 | The efficacy of diltiazem and glyceryltrinitrate for the medical management of chronic anal fissure: a meta-analysis. ( Baig, MK; Cheek, E; Rimple, J; Sajid, MS, 2008) |
| "4% Nitroglycerin ointment is an intra-anal formulation of nitroglycerin (glyceryl trinitrate) indicated for the treatment of chronic anal fissure pain." | 4.83 | 0.4% nitroglycerin ointment : in the treatment of chronic anal fissure pain. ( Easthope, SE; Fenton, C; Wellington, K, 2006) |
| "This study explores the evidence-based background for treating chronic anal fissure with topically applied nitroglycerin (NTG): in part the general effect of NTG and in part how its effect compares to that of surgery, which has been claimed to have long-term complications like incontinence for flatus and faeces." | 4.81 | [Treatment of chronic anal fissure with topically applied nitroglycerin ointment. A systematic review of evidence-based results]. ( Matzen, P; Svendsen, CB, 2002) |
| " Local application of nitroglycerin is very safe and can be used by physicians in general practice for chronic anal fissure." | 4.81 | [Nitric oxide donors and their potentiating effects after botulinum toxin application for treatment of chronic anal fissure]. ( Adrich, Z; Kryszewski, A; Madaliński, M, 2002) |
| " The authors describe their clinical practice during the last 15 years: nitrates with short half-life in the treatment of acute pancreatitis (amylnitrit or nitroglycerin spray) which have a low risk of developing nitrate tolerance; chronic administration of retard nitroglycerin in chronic pancreatitis and Oddi's sphincter hypertonic dyskinesia." | 4.78 | The role of nitroglycerin preparations in the treatment of post-acute and chronic pancreatitis. ( Berger, Z; Pap, A, 1993) |
| " Acute pulmonary edema can be successfully treated with single or repeated doses of sublingual nitroglycerin." | 4.78 | Nitrate therapy in heart failure. ( Bussmann, WD; Hartmann, A; Kaltenbach, M; Schneider, W, 1991) |
| "Nitroglycerin and its derivatives have become widely used agents in the treatment of severe forms of heart failure." | 4.77 | [Use of nitroglycerin in the treatment of congestive heart failure]. ( Curyło, AM, 1989) |
| "(2,3) Conservative management options for chronic Achilles tendinopathy include eccentric (lengthening) exercises, extracorporeal shockwave therapy (ESWT), topical nitroglycerin, low level laser therapy, orthoses, splints or injections (e." | 3.78 | Management of chronic Achilles tendinopathy. ( , 2012) |
| "The aim of this study was to investigate whether the neuropeptide calcitonin gene related peptide (CGRP) contributes to nitroglycerin (GTN) response in patients with chronic heart failure (CHF) and the association with the mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys (ALDH2*2) polymorphism." | 3.78 | Influence of ALDH2 Glu504Lys polymorphism on nitroglycerin response in chronic heart failure and involvement of Calcitonin Gene Related Peptide (CGRP). ( Chen, XP; Guo, YJ; Li, CC; Li, L; Li, YJ; Mo, L; Peng, LM; Sun, J; Xie, W; Yang, TL, 2012) |
| " Endothelium-dependent and -independent vasodilation (EDV and EIDV) was studied in the reactive hyperemia (RH) test and nitroglycerin (NTG) test." | 3.78 | [Vascular remodeling indicators and their impact on prognosis in patients with chronic heart failure]. ( Kosheleva, NA; Rebrov, AP, 2012) |
| "Nitroglycerin dose-dependently increases tissue perfusion in patients with severe heart failure, as observed by a decrease in central-peripheral temperature gradient and an increase in sublingual perfused capillary density." | 3.75 | Dose-dependent benefit of nitroglycerin on microcirculation of patients with severe heart failure. ( Caliskan, K; den Uil, CA; Jewbali, LS; Lagrand, WK; Simoons, ML; Spronk, PE; van der Ent, M; van Kuijk, JP, 2009) |
| "2% glycerl trinitrate (GTN) and topical 2% diltiazem (DTZ), in the management of chronic anal fissure." | 3.75 | Diltiazem (2%) versus glyceryl trinitrate cream (0.2%) in the management of chronic anal fissure. ( Hashmi, F; Siddiqui, FG, 2009) |
| "Patients with chronic heart failure (CHF) often require higher doses of nitroglycerin (glyceryl trinitrate, GTN) than patients with normal cardiac function to achieve a given haemodynamic goal." | 3.74 | Impaired nitroglycerin biotransformation in patients with chronic heart failure. ( Adams, MA; Bennett, BM; Friberg, P; Petersson, M; Rundqvist, B, 2008) |
| "Both topical diltiazem, a calcium channel blocker, and glyceryl trinitrate, a nitric oxide donor, lower anal pressure and heal two-thirds of chronic anal fissures." | 3.71 | Diltiazem heals glyceryl trinitrate-resistant chronic anal fissures: a prospective study. ( Jonas, M; Scholefield, JH; Speake, W, 2002) |
| "In 42 unmedicated patients with hypertension and electrocardiographic left ventricular hypertrophy, we measured the following: 24-h ambulatory blood pressure (BP), minimal forearm vascular resistance (MFVR) by plethysmography, intima-media cross-sectional area of the common carotid arteries (IMA), FMD, and nitroglycerin-induced dilatation (NID) in the brachial artery by ultrasound." | 3.71 | Vasodilatory capacity and vascular structure in long-standing hypertension: a LIFE substudy. Losartan Intervention For Endpoint-Reduction in Hypertension. ( Aalkjaer, C; Dige-Petersen, H; Ibsen, H; Olsen, MH; Rokkedal, J; Wachtell, K, 2002) |
| " Systemic administration of nitroglycerin (NTG) or mild hypoxia resulted in a decreased of c-fos expression in the dorsolateral part of the denervated neostriatum." | 3.71 | Fos and nitric oxide synthase in rat brain with chronic mesostriatal dopamine deficiency: effects of nitroglycerin and hypoxia. ( Appenzeller, O; Bazilyuk, OV; Maisky, VA; Oleshko, NN; Sagach, VF; Talanov, SA, 2002) |
| "Topical nitroglycerin was only effective in approximately one-half of patients with an anal fissure." | 3.70 | Nitroglycerin ointment for anal fissures: effective treatment or just a headache? ( Cataldo, PA; Hyman, NH, 1999) |
| "Rapid atrial pacing was used to induce myocardial ischemia, with the same pacing rate before and after an intracoronary injection of 50 micrograms nitroglycerin." | 3.69 | Variable responses of highly stenotic coronary arteries and collateral circulation to intracoronary injection of nitroglycerin in patients with chronic effort angina. ( Fujita, M; Inoko, M; Miwa, K; Yamanishi, K, 1994) |
| "This study was designed to determine the efficacy of L-arginine in healing of gastric ulcers induced by acetic acid and to assess the role of nitric oxide (NO), prostaglandins, gastrin and polyamines in the healing process." | 3.69 | Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide, prostaglandins, gastrin and polyamines. ( Brzozowski, T; Dembiński, A; Drozdowicz, D; Konturek, SJ; Stachura, J, 1995) |
| "Vasorelaxation by histamine, iloprost and nitroglycerin are impaired in hypertension." | 3.68 | Vascular smooth muscle responses to endothelial autacoids in rats with chronic coarctation hypertension. ( Bell, DR, 1993) |
| "The goal of this study was to determine the role of prostaglandin H2-thromboxane A2 (PGH2-TxA2) in altered responses of cerebral arterioles during chronic hypertension." | 3.68 | Role of prostaglandin H2-thromboxane A2 in responses of cerebral arterioles during chronic hypertension. ( Mayhan, WG, 1992) |
| " To test whether endothelial dysfunction might be involved, the effect of acetylcholine, nitroglycerin, and NG-monomethyl-L-arginine (L-NMMA) was investigated in a constant-flow perfused hindquarter of rats with and without chronic heart failure (CHF) due to myocardial infarction." | 3.68 | Endothelial dysfunction of hindquarter resistance vessels in experimental heart failure. ( Drexler, H; Lu, W, 1992) |
| "The effects of single, consecutively increased, oral doses of the beta-adrenoceptor antagonist bisoprolol (5, 10, 15, 20, 30 and 40 mg) on blood pressure, heart rate and bronchomotor tone were investigated in an open acute trial with 16 patients suffering from angina pectoris due to coronary heart disease and reversible chronic obstructive bronchitis." | 3.67 | Dose-response relationship of the beta-adrenoceptor antagonist bisoprolol in patients with coronary heart disease and chronic obstructive bronchitis. ( Dorow, P; Tönnesmann, U, 1984) |
| "On the basis of the examination of 113 patients the author considers that patients with abdominal pains associated with the amount of food, progressing loss of weight, systolic noise in the projection of visceral arteries, positive nitroglycerine and thermal tests have high probability of detection of the syndrome of chronic abdominal ischemia." | 3.67 | [Diagnosis of chronic occlusive diseases of the visceral branches of the abdominal aorta]. ( Zigmantovich, IuM, 1985) |
| "Kinetocardiography and integral rheography of the body were used to examine the effect of nitroglycerin on the hemodynamics in 17 patients with chronic obstructive bronchitis complicated by pulmonary hypertension." | 3.67 | [Effect of nitroglycerin on various indicators of hemodynamics in patients with chronic obstructive bronchitis complicated by pulmonary hypertension]. ( Aleksandrov, AL; Cherniakova, TG; Matkovskii, SK, 1985) |
| "The hemodynamic and hormonal responses to nitroglycerin administered transdermally in a gel-like matrix were evaluated in nine patients with severe congestive heart failure and in nine normal subjects." | 3.66 | Hemodynamic and hormonal response to transdermal nitroglycerin in normal subjects and in patients with congestive heart failure. ( Carlyle, PF; Cohn, JN; Levine, TB; Olivari, MT, 1983) |
| " Hemodynamic effects o high doses of oral isosorbide dinitrate in patients with chronic heart failure (N - 13)." | 3.66 | Hemodynamic effects of nitrates in chronic heart failure and myocardial infarction. ( Chatterjee, K, 1980) |
| "The hemodynamic effects of nitroglycerin absorbed transcutaneously from an ointment base were determined in 10 patients with chronic congestive heart failure (9 with ischemic heart disease and 1 with cardiomyopathy)." | 3.65 | Hemodynamic effects of nitroglycerin ointment in congestive heart failure. ( Chatterjee, K; Forrester, JS; Magnusson, P; Swan, HJ; Takano, T; Taylor, WR, 1976) |
| "A patient with severe, chronic congestive heart failure was unresponsive not only to conventional therapy, but also to nonparenteral nitroglycerin and isosorbide dinitrate; he became nitroprusside dependent." | 3.65 | Combination vasodilator therapy for severe chronic congestive heart failure. ( Chatterjee, K; Drew, D; Klausner, SC; Parmley, WW; Polansky, J; Zacherle, B, 1976) |
| " The secondary outcomes recorded at the same time points were healing rate, visual analogue scales for itching and burning, rate of complications and adverse events, patient quality of life and satisfaction, and cost analysis." | 3.30 | Efficacy and safety of Propionibacterium extract gel versus glyceryl trinitrate ointment in the treatment of chronic anal fissure: a randomized controlled trial. ( Altomare, DF; Cantarella, F; Currò, G; Fulginiti, S; Gallo, G; Grossi, U; La Torre, M; Rinaldi, M; Santoro, GA; Tierno, S; Tomasicchio, G; Trompetto, M; Vanini, P, 2023) |
| "Anal fissure is one of the most common benign anal disorders, and medical treatments play an important role in its management." | 3.01 | Short-term Results of Platelet-Rich Plasma in the Treatment of Chronic Anal Fissure: Randomized Controlled Clinical Study. ( Tanrikulu, Y; Yilmaz, G, 2021) |
| "Anal fissure is a common condition that can be treated medically or surgically." | 2.82 | A systematic review and meta-analysis of the efficacy of topical sphincterotomy treatments for anal fissure. ( Connolly, A; Hardy, MO; Hill, AG; Jin, JZ; Mauiliu-Wallis, M; Singh, PP; Unasa, H; Weston, M, 2022) |
| "Diltiazem gel was found to be superior to Glyceril trinitrate ointment due to significantly higher healing rate and fewer side-effects." | 2.77 | Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double-blind trial. ( Ala, S; Ghorbanian, A; Hadianamrei, R; Saeedi, M, 2012) |
| "Allopurinol seems to be a useful, inexpensive, well tolerated, and safe anti-ischaemic drug for patients with angina." | 2.75 | Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial. ( Ang, DS; Lang, CC; Noman, A; Ogston, S; Struthers, AD, 2010) |
| "Chronic anal fissure is a common benign disorder; for this condition, lateral internal sphincterotomy is the "gold standard" of treatment." | 2.74 | Glyceryl trinitrate ointment (0.25%) and anal cryothermal dilators in the treatment of chronic anal fissures. ( Munegato, G; Schiano di Visconte, M, 2009) |
| "Ruboxistaurin is a selective protein kinase C beta inhibitor undergoing clinical investigation for treatment of diabetic microvascular complications." | 2.73 | Inhibition of PKC beta by ruboxistaurin does not enhance the acute blood pressure response to nitroglycerin. ( Benson, C; Seger, M; Voelker, J, 2007) |
| "Diltiazem ointment was found to be superior regarding pain relief, fewer side effects, and late recurrence as compared with GTN ointment." | 2.73 | A comparison of the effects of diltiazem and glyceryl trinitrate ointment in the treatment of chronic anal fissure: a randomized clinical trial. ( Jain, BK; Kumar, P; Saifee, Y; Shrivastava, UK, 2007) |
| "This study addressed the dose-response to three different concentrations of GTN ointment compared with placebo in a double blind randomised controlled trial." | 2.71 | A dose finding study with 0.1%, 0.2%, and 0.4% glyceryl trinitrate ointment in patients with chronic anal fissures. ( Athanasiadis, S; Bock, JU; Herold, A; Marla, B; Pröls, M; Richter, HJ; Scholefield, JH, 2003) |
| "A prospective, randomized, double-blind, placebo-controlled trial involving a total of sixty-five patients (eighty-four Achilles tendons) was performed to compare continuous application of topical glyceryl trinitrate (at a dosage of 1." | 2.71 | Topical glyceryl trinitrate treatment of chronic noninsertional achilles tendinopathy. A randomized, double-blind, placebo-controlled trial. ( Appleyard, RC; Murrell, GA; Nelson, J; Paoloni, JA, 2004) |
| "Anal fissure was completely healed in 38 (73%) and 24 (64%) of the patients after 6 weeks and 48 (81%) and 27 (79%) of the patients in transdermal group and ointment group, respectively." | 2.71 | A randomised study comparing systemic transdermal treatment and local application of glyceryl trinitrate ointment in the management of chronic anal fissure. ( Colak, T; Dirlik, M; Ipek, T; Kanik, A; Urkaya, N, 2003) |
| " However, because the physiologic response has resolved in fewer than 20 minutes, the dosing regime should be reassessed." | 2.71 | Manometric effect of topical glyceryl trinitrate and its impact on chronic anal fissure healing. ( Kennedy, ML; King, DW; Thornton, MJ, 2005) |
| "Nitroglycerin or placebo was administered in two daily applications for two weeks." | 2.70 | Long-term results of topical nitroglycerin in the treatment of chronic anal fissures are disappointing. ( Bisisio, O; Graziano, A; Gualdrini, U; Lencinas, S; Masciangioli, G; Svidler López, L, 2001) |
| "Significant recurrence of symptomatic fissures and a high incidence of headaches are limitations of the treatment." | 2.69 | Randomised controlled trial shows that glyceryl trinitrate heals anal fissures, higher doses are not more effective, and there is a high recurrence rate. ( Carapeti, EA; Chadwick, SJ; Kamm, MA; McDonald, PJ; Melville, D; Phillips, RK, 1999) |
| "Pain was recorded on a linear analog scale." | 2.69 | Glyceryl trinitrate ointment for the treatment of chronic anal fissure: results of a placebo-controlled trial and long-term follow-up. ( Kennedy, ML; Lubowski, DZ; Nguyen, H; Sowter, S, 1999) |
| "Internal anal sphincterotomy for treating chronic anal fissure can irreversibly damage anal continence." | 2.69 | Glyceryl trinitrate for chronic anal fissure--healing or headache? Results of a multicenter, randomized, placebo-controled, double-blind trial. ( Altomare, DF; Arcanà, F; Bottini, C; Lovreglio, R; Milito, G; Nardelli, N; Pescatori, M; Pulvirenti-D'Urso, A; Rinaldi, M; Scardigno, D; Spinelli, F, 2000) |
| "Chronic anal fissure is a frequent and troubling condition, that may need surgical sphincterotomy for relief of symptoms." | 2.69 | Double-blind manometric assessment of two topical glyceryl trinitrate formulations in patients with chronic anal fissures. ( Bassotti, G; Ceccarelli, F; Clementi, M; Pelli, MA, 2000) |
| "Anal fissure is most commonly treated surgically by internal anal sphincterotomy." | 2.68 | A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. ( Lund, JN; Scholefield, JH, 1997) |
| "Four recurrences were successfully treated by further GTN ointment and one by sphincterotomy." | 2.68 | Glyceryl trinitrate is an effective treatment for anal fissure. ( Lund, JN; Scholefield, JH, 1997) |
| "Mibefradil-treated patients showed greater decreases in heart rate and the rate-pressure product at each stage of the ETT than patients treated with amlodipine or diltiazem SR." | 2.68 | Mibefradil in the treatment of chronic stable angina pectoris: comparative studies with other calcium antagonists. ( Davies, GJ; Kobrin, I; Tzivoni, D, 1997) |
| " However, 2 h after dosing there was a significant prolongation during stress testing in the time to onset of both 1 mm ST depression on the ECG (by 28%) and to angina (by 37%) compared with atenolol alone, but no benefit was apparent by 12 h after dosing." | 2.66 | Slow release nifedipine plus atenolol in chronic stable angina pectoris. ( Challenor, VF; George, CF; Renwick, AG; Waller, DG, 1989) |
| "Enalapril was used to inhibit angiotensin converting enzyme." | 2.66 | The variable effects of angiotensin converting enzyme inhibition on myocardial ischaemia in chronic stable angina. ( Crean, PA; Fox, KM; Gibbs, R; Mockus, L; Simon, J; Sutton, GC; Wright, C, 1989) |
| " Nifedipine pharmacokinetics after a single oral dose and sustained dosing (three times daily for five days) were not significantly different." | 2.66 | Haemodynamic effects of combined oral nifedipine and sublingual nitroglycerin in patients with chronic stable angina. ( Boje, KM; Fung, HL; Parker, JO; Yoshitomi, K, 1987) |
| "The term tendinopathy is preferred to tendinitis because of the presence of a disordered and degenerative healing process-not inflammation-in the pathologic tendon." | 2.61 | Management of Chronic Tendon Injuries. ( Kane, SF; Olewinski, LH; Tamminga, KS, 2019) |
| "Anal fissure is one of the most common and painful proctologic diseases." | 2.47 | The management of patients with primary chronic anal fissure: a position paper. ( Altomare, DF; Binda, GA; Canuti, S; Landolfi, V; Trompetto, M; Villani, RD, 2011) |
| "Anal fissure is a common disorder that is effectively treated and prevented with conservative measures in its acute form, whereas chronic fissures may require medical or surgical therapy." | 2.46 | Anal fissure. ( Herzig, DO; Lu, KC, 2010) |
| "Smooth muscle relaxation is well tolerated, can be administered on an outpatient basis, does not cause any lesion of the continence organ, and subsequently, does not lead to any permanent latent or apparent fecal incontinence." | 2.44 | Nonsurgical approaches for the treatment of anal fissures. ( Chopra, S; Dhawan, S, 2007) |
| "Anal fissures are commonly encountered in routine colorectal practice." | 2.44 | Modern perspectives in the treatment of chronic anal fissures. ( Bhardwaj, R; Parker, MC, 2007) |
| "Achilles tendinopathy is generally caused by chronic stress to the tendon, leading to a defective arrangement of collagen fibers in the Achilles tendon." | 2.44 | Noninsertional Achilles tendinopathy: pathology and management. ( McCabe, F; McShane, JM; Ostick, B, 2007) |
| "Anal fissure is a common disorder which may cause symptoms at any age." | 2.43 | Chemical sphincterotomy--first line of treatment for chronic anal fissure. ( Baten, MA; Chowdhury, RA; Haq, Z; Khatun, M; Rahman, M, 2005) |
| "Chronic anal fissure is a tear in the lining of the anal canal that, if not treated appropriately at an early stage, causes considerable anal pain during defaecation." | 2.43 | Pharmacological advancements in the treatment of chronic anal fissure. ( Acheson, AG; Scholefield, JH, 2005) |
| "Therefore, pharmacological means to treat chronic anal fissures have been explored." | 2.42 | Concepts in pathogenesis and treatment of chronic anal fissure--a review of the literature. ( Buhr, HJ; Kroesen, AJ; Utzig, MJ, 2003) |
| "Anal fissures are common conditions, presenting with bleeding, itching, and pain of varying severity." | 2.41 | Anal fissures. ( Lubowski, DZ, 2000) |
| "Chronic anal fissure is a common and painful condition associated with internal anal sphincter hypertonia." | 2.41 | Progress in the understanding and treatment of chronic anal fissure. ( Gardiner, KR; McCallion, K, 2001) |
| "Anal fissure is one of the most common and painful proctological pathologies affecting mainly young individuals." | 2.40 | Fissure-in-ano, to divide or not to divide? ( Brugman, T; Bruyninx, L; Jacquet, NJ, 1999) |
| "Nisoldipine is a second-generation dihydropyridine calcium antagonist that has been extensively studied as an antianginal and antihypertensive agent." | 2.39 | Nisoldipine coat core as concomitant therapy in chronic stable angina pectoris. ( Glasser, SP, 1995) |
| "Pain and constipation were assessed prior to treatment and at 6 weeks after therapy using visual analogue scale (VAS) and Wexner constipation score." | 1.46 | Does the duration of symptoms of anal fissure impact its response to conservative treatment? A prospective cohort study. ( Abdelmawla, AA; Abdelnaby, M; Elfeki, H; Elgendy, H; Emile, SH; Khafagy, W; Magdy, A, 2017) |
| "This chronic basal hyperalgesia occurred in a dose-dependent fashion and persisted for days after cessation of NTG administration." | 1.40 | Characterization of a novel model of chronic migraine. ( Charles, A; Evans, CJ; McGuire, B; Pradhan, AA; Smith, ML; Tarash, I, 2014) |
| "(1) Anal fissures are very painful but often heal spontaneously." | 1.35 | 0.4% glyceryl trinitrate ointment: new drug. Not useful for anal fissures. ( , 2008) |
| "Although headache is a frequent side-effect, it is usually transient and glyceryl trinitrate does not seem to have any long-term adverse effects." | 1.35 | [The role of glyceryl trinitrate in the treatment of anal fissure]. ( Bursics, A; Takáts, K; Tóth, A, 2008) |
| "Coronary artery disease is associated with impaired endothelium-dependent dilatation and impaired stimulation of t-PA release in the systemic circulation." | 1.33 | Endothelial dysfunction occurs in peripheral circulation patients with acute and stable coronary artery disease. ( Adams, MR; Celermajer, DS; Thanyasiri, P, 2005) |
| "All students had chronic sleep deprivation for 4 weeks, during which sleep lasted < 80% of that on ordinary days; in addition, the students were under great stress to pass the examination." | 1.32 | Effect of chronic stress and sleep deprivation on both flow-mediated dilation in the brachial artery and the intracellular magnesium level in humans. ( Akima, T; Kurita, A; Ohsuzu, F; Takase, B; Uehata, A, 2004) |
| "Treatment with sarpogrelate significantly increased the SAS score and prolonged exercise time to the onset of 0." | 1.31 | Effectiveness of a novel serotonin blocker, sarpogrelate, for patients with angina pectoris. ( Fujita, M; Hanada, H; Kinugawa, T; Lee, JD; Miyamoto, S; Nakajima, H, 2002) |
| "There has been an emerging trend to treat chronic anal fissures by pharmacologic means." | 1.30 | Treatment of chronic anal fissure with topical glyceryl trinitrate. ( Dorfman, G; Levitt, M; Platell, C, 1999) |
| "The restenosis rate after recanalization of chronic totally occluded coronary arteries is high." | 1.29 | Restoration of coronary blood flow in severely narrowed and chronically occluded coronary arteries before and after angioplasty: implications regarding restenosis. ( Dubois-Randé, JL; Dupouy, P; Geschwind, HJ; Zelinsky, R, 1994) |
| "The aetiology of anal fissure is unclear, but there is an association with high maximum resting pressure (MRP)." | 1.29 | Topical glyceryl trinitrate in the treatment of chronic anal fissure. ( Kamm, MA; Nicholls, RJ; Phillips, RK; Watson, SJ, 1996) |
| "Anal fissure is often treated surgically by sphincterotomy." | 1.29 | Use of glyceryl trinitrate ointment in the treatment of anal fissure. ( Armitage, NC; Lund, JN; Scholefield, JH, 1996) |
| "Nine patients with chronic cluster headache were studied as to end-tidal PCO2, heart rate, blood pressure, common carotid artery blood flow, vascular resistance, and intensity and duration of pain before, during, and after breathing 6% CO2 in air for 6 minutes and before and after administration of 1 mg nitroglycerin sublingually." | 1.29 | Chronic cluster headache: provocation with carbon dioxide breathing and nitroglycerin. ( Hannerz, J; Jogestrand, T, 1996) |
| "Nitroglycerin, 10(-5) M, was administered to 10 patients; all 10 demonstrated a pattern characteristic of vasodilation." | 1.28 | Impaired endothelium-mediated vasodilation in the peripheral vasculature of patients with congestive heart failure. ( Biasucci, L; Forman, R; Galvao, M; Jondeau, G; Katz, SD; LeJemtel, TH; Nikolic, SD; Sabba, C; Solomon, S; Strom, JA, 1992) |
| " A fortnight nitrogen regimen in a dosage of 2." | 1.28 | [Effect of nitroglycerin preparations on indicators of central hemodynamics in patients with pulmonary tuberculosis complicated by chronic cor pulmonale]. ( Mar'iandyshev, AO, 1990) |
| "In all 20 patients, ventricular arrhythmias were consistently present during both tests on placebo, that were markedly reduced by nitroglycerin." | 1.28 | [Intravenous nitroglycerin infusion suppresses exercise-induced arrhythmia in patients with ischemic cardiopathy: indications for chronic treatment ]. ( Bonetti, F; Chierchia, SL; Cianflone, D; Mailhac, A; Margonato, A; Scarpazza, P; Vicedomini, G, 1990) |
| "Captopril is a mixed vasodilator and is effective from the first hour of administration." | 1.27 | [Enhancement of the effect of captopril in the 1st 48 hours of treating refractory heart failure. A comparison with intravenous trinitrine]. ( Baubion, N; Di Matteo, J; Heulin, A; Le Pailleur, C; Metzger, JP; Vacheron, A, 1984) |
| "Isosorbide dinitrate was used in 16 patients, nitroglycerin in 36, pratsiol in 24, and captopryl in 20 patients." | 1.27 | [Comparative evaluation of the effectiveness of various peripheral vasodilators in the treatment of cardiac insufficiency]. ( Ageev, FT; Evdokimova, NKh; Mareev, VIu; Mukharliamov, NM; Novikov, SV, 1985) |
| " After a 2-week placebo period ISMN was administered in a single-blind fashion with the dosage being titrated at 2-week intervals." | 1.27 | Isosorbide-5-mononitrate--effective monotherapy in chronic stable angina. ( Akhras, F; Jackson, G; Jefferies, S, 1985) |
| "Nitroglycerin was administered to a group of 11 patients with chronic obstructive pulmonary disease in a dose of 0." | 1.25 | The effect of nitroglycerin in gas exchange on chronic obstructive pulmonary disease. ( Chick, TW; Jenne, JW; Kochukoshy, KN, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 85 (27.16) | 18.7374 |
| 1990's | 70 (22.36) | 18.2507 |
| 2000's | 111 (35.46) | 29.6817 |
| 2010's | 35 (11.18) | 24.3611 |
| 2020's | 12 (3.83) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, JZ | 1 |
| Hardy, MO | 1 |
| Unasa, H | 1 |
| Mauiliu-Wallis, M | 1 |
| Weston, M | 1 |
| Connolly, A | 1 |
| Singh, PP | 1 |
| Hill, AG | 1 |
| Garg, P | 1 |
| Butala, NM | 1 |
| Tamez, H | 1 |
| Secemsky, EA | 1 |
| Grantham, JA | 1 |
| Spertus, JA | 2 |
| Cohen, DJ | 1 |
| Jones, P | 1 |
| Salisbury, AC | 1 |
| Arnold, SV | 1 |
| Harrell, F | 1 |
| Lombardi, W | 1 |
| Karmpaliotis, D | 1 |
| Moses, J | 1 |
| Sapontis, J | 1 |
| Yeh, RW | 1 |
| Mustafa, G | 1 |
| Hossain, MS | 1 |
| Sheikh, SH | 1 |
| Faruk, I | 1 |
| Taher, MA | 1 |
| Ferdaus, AM | 1 |
| Fatema, B | 1 |
| Alam, A | 1 |
| Tasnim, T | 1 |
| Sierra-Arango, F | 1 |
| de la Hoz-Valle, J | 1 |
| Espinosa, JP | 1 |
| Moreno-Montoya, J | 1 |
| Vásquez Roldan, M | 1 |
| Pérez-Riveros, ED | 1 |
| Fagan, C | 1 |
| Kolber, MR | 1 |
| Lindblad, AJ | 1 |
| Gallo, G | 1 |
| Trompetto, M | 2 |
| Fulginiti, S | 1 |
| La Torre, M | 1 |
| Tierno, S | 1 |
| Cantarella, F | 1 |
| Vanini, P | 1 |
| Tomasicchio, G | 1 |
| Altomare, DF | 4 |
| Rinaldi, M | 2 |
| Santoro, GA | 1 |
| Currò, G | 1 |
| Grossi, U | 1 |
| Damin, DC | 1 |
| Contu, PC | 1 |
| Snelgrove, H | 1 |
| Baileff, A | 1 |
| Emile, SH | 2 |
| Abdel-Razik, MA | 1 |
| Elshobaky, A | 1 |
| Elbaz, SA | 1 |
| Khafagy, W | 2 |
| Shalaby, M | 1 |
| Acar, T | 1 |
| Acar, N | 1 |
| Güngör, F | 1 |
| Kamer, E | 1 |
| Genç, H | 1 |
| Atahan, K | 1 |
| Dilek, ON | 1 |
| Hacıyanlı, M | 1 |
| Yilmaz, G | 1 |
| Tanrikulu, Y | 1 |
| Jiang, L | 1 |
| Zhang, Y | 1 |
| Jing, F | 1 |
| Long, T | 1 |
| Qin, G | 1 |
| Zhang, D | 1 |
| Chen, L | 1 |
| Zhou, J | 1 |
| Elgendy, H | 1 |
| Elfeki, H | 1 |
| Magdy, A | 1 |
| Abdelmawla, AA | 1 |
| Abdelnaby, M | 1 |
| Kane, SF | 1 |
| Olewinski, LH | 1 |
| Tamminga, KS | 1 |
| Ala, S | 1 |
| Saeedi, M | 1 |
| Hadianamrei, R | 1 |
| Ghorbanian, A | 1 |
| Aslam, MI | 1 |
| Pervaiz, A | 1 |
| Figueiredo, R | 1 |
| Pradhan, AA | 1 |
| Smith, ML | 1 |
| McGuire, B | 1 |
| Tarash, I | 1 |
| Evans, CJ | 1 |
| Charles, A | 1 |
| Asim, M | 1 |
| Lowrie, N | 1 |
| Stewart, J | 1 |
| Lolohea, S | 1 |
| Van Dalen, R | 1 |
| Komarów, W | 1 |
| Hawro, P | 1 |
| Lekston, A | 1 |
| Urbanek, T | 1 |
| Zagrodzki, P | 1 |
| Brillantino, A | 1 |
| Iacobellis, F | 1 |
| Izzo, G | 1 |
| Di Martino, N | 1 |
| Grassi, R | 1 |
| Renzi, A | 1 |
| Takahashi, J | 1 |
| Nihei, T | 1 |
| Takagi, Y | 1 |
| Miyata, S | 1 |
| Odaka, Y | 1 |
| Tsunoda, R | 1 |
| Seki, A | 1 |
| Sumiyoshi, T | 1 |
| Matsui, M | 1 |
| Goto, T | 1 |
| Tanabe, Y | 1 |
| Sueda, S | 1 |
| Momomura, S | 1 |
| Yasuda, S | 1 |
| Ogawa, H | 2 |
| Shimokawa, H | 1 |
| Vershenya, S | 1 |
| Klotz, J | 1 |
| Joos, A | 1 |
| Bussen, D | 1 |
| Herold, A | 2 |
| Page, RL | 1 |
| Ghushchyan, V | 1 |
| Read, RA | 1 |
| Hartsfield, CL | 1 |
| Koch, BR | 1 |
| Nair, KV | 1 |
| Motie, MR | 1 |
| Hashemi, P | 1 |
| Imran, TF | 1 |
| Malapero, R | 1 |
| Qavi, AH | 1 |
| Hasan, Z | 1 |
| de la Torre, B | 1 |
| Patel, YR | 1 |
| Yong, RJ | 1 |
| Djousse, L | 1 |
| Gaziano, JM | 1 |
| Gerhard-Herman, MD | 1 |
| Ruiz-Tovar, J | 3 |
| Llavero, C | 1 |
| Tanaka, S | 1 |
| Yokoyama, C | 1 |
| Kawamura, I | 1 |
| Takasugi, N | 1 |
| Kubota, T | 1 |
| Ushikoshi, H | 1 |
| Aoyama, T | 1 |
| Kawasaki, M | 1 |
| Nishigaki, K | 1 |
| Takemura, G | 1 |
| Minatoguchi, S | 1 |
| Medhi, B | 1 |
| Rao, RS | 1 |
| Prakash, A | 1 |
| Prakash, O | 1 |
| Kaman, L | 1 |
| Pandhi, P | 1 |
| Singh, JC | 1 |
| Davies, M | 1 |
| Khot, U | 1 |
| Chandrasekaran, TV | 1 |
| Carr, ND | 1 |
| Beynon, J | 1 |
| Siddique, MI | 1 |
| Murshed, KM | 1 |
| Majid, MA | 1 |
| Takáts, K | 1 |
| Tóth, A | 1 |
| Bursics, A | 1 |
| Paoloni, JA | 5 |
| Murrell, GA | 5 |
| Burch, RM | 1 |
| Ang, RY | 1 |
| Schiano di Visconte, M | 2 |
| Munegato, G | 2 |
| Irkorucu, O | 1 |
| Ucan, HB | 1 |
| Comert, M | 1 |
| McCallum, SD | 1 |
| den Uil, CA | 1 |
| Caliskan, K | 1 |
| Lagrand, WK | 1 |
| van der Ent, M | 1 |
| Jewbali, LS | 1 |
| van Kuijk, JP | 1 |
| Spronk, PE | 1 |
| Simoons, ML | 1 |
| Jawaid, M | 1 |
| Masood, Z | 1 |
| Salim, M | 1 |
| Hashmi, F | 1 |
| Siddiqui, FG | 1 |
| Herzig, DO | 1 |
| Lu, KC | 1 |
| Abd Elhady, HM | 1 |
| Othman, IH | 1 |
| Hablus, MA | 1 |
| Ismail, TA | 1 |
| Aboryia, MH | 1 |
| Selim, MF | 1 |
| Sileri, P | 2 |
| Stolfi, VM | 2 |
| Franceschilli, L | 1 |
| Grande, M | 2 |
| Di Giorgio, A | 1 |
| D'Ugo, S | 1 |
| Attina', G | 1 |
| D'Eletto, M | 1 |
| Gaspari, AL | 2 |
| Puche, JJ | 1 |
| García-Coret, MJ | 1 |
| Villalba, FL | 1 |
| Ali-Mahmoud, I | 1 |
| Roig, JV | 1 |
| Reffelmann, T | 1 |
| Kloner, RA | 1 |
| Noman, A | 1 |
| Ang, DS | 1 |
| Ogston, S | 1 |
| Lang, CC | 1 |
| Struthers, AD | 1 |
| Gagliardi, G | 1 |
| Pascariello, A | 1 |
| Arcanà, F | 2 |
| Cafaro, D | 1 |
| La Torre, F | 1 |
| De Nardi, P | 2 |
| Basso, L | 1 |
| De Stefano, I | 1 |
| Greco, VJ | 1 |
| Vasapollo, L | 1 |
| Amato, A | 1 |
| Pulvirenti D'Urso, A | 1 |
| Aiello, D | 1 |
| Bove, A | 1 |
| Gambito, ED | 1 |
| Gonzalez-Suarez, CB | 1 |
| Oquiñena, TI | 1 |
| Agbayani, RB | 1 |
| Binda, GA | 1 |
| Canuti, S | 1 |
| Landolfi, V | 1 |
| Villani, RD | 1 |
| Sinha, R | 1 |
| Kaiser, AM | 2 |
| Fumero, A | 1 |
| Lapenna, E | 1 |
| Taramasso, M | 1 |
| Alfieri, O | 1 |
| Perez-Legaz, J | 2 |
| Arroyo, A | 2 |
| Lopez-Delgado, A | 1 |
| Frangi, A | 2 |
| Moya, P | 2 |
| Santos, J | 1 |
| Candela, F | 2 |
| Calpena, R | 2 |
| Reeder, DN | 1 |
| Gillette, MA | 1 |
| Franck, AJ | 1 |
| Frohnapple, DJ | 1 |
| Galassi, AR | 2 |
| Tomasello, SD | 1 |
| Crea, F | 2 |
| Costanzo, L | 1 |
| Campisano, MB | 1 |
| Marzá, F | 1 |
| Tamburino, C | 1 |
| Sajid, MS | 3 |
| Whitehouse, PA | 1 |
| Sains, P | 1 |
| Baig, MK | 3 |
| Oliver, MI | 1 |
| Peng, LM | 1 |
| Chen, XP | 1 |
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| Guo, YJ | 1 |
| Li, L | 1 |
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| Li, YJ | 1 |
| Yang, TL | 1 |
| Li, CC | 1 |
| Kosheleva, NA | 1 |
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| Barrios, V | 1 |
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| Lee, JD | 1 |
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| Hanada, H | 1 |
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| Griffin, N | 1 |
| Scholefield, JH | 10 |
| Briel, JW | 1 |
| Zimmerman, DD | 1 |
| Schouten, WR | 1 |
| Jonas, M | 2 |
| Speake, W | 1 |
| Svendsen, CB | 1 |
| Matzen, P | 1 |
| Balaji, NS | 1 |
| Ahmad, M | 1 |
| Bailey, HR | 1 |
| Beck, DE | 1 |
| Billingham, RP | 1 |
| Binderow, SR | 1 |
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| Margolin, DA | 1 |
| Milsom, JW | 1 |
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| Sands, LR | 2 |
| Senagore, A | 1 |
| Stamos, MJ | 1 |
| Yee, LF | 1 |
| Young-Fadok, TM | 1 |
| Gibbons, RD | 1 |
| Libertiny, G | 1 |
| Knight, JS | 1 |
| Farouk, R | 2 |
| Garner, JP | 1 |
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| Bock, JU | 1 |
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| Richter, HJ | 1 |
| Athanasiadis, S | 1 |
| Pröls, M | 1 |
| Lindsey, I | 1 |
| Jones, OM | 1 |
| Cunningham, C | 1 |
| George, BD | 1 |
| Mortensen, NJ | 1 |
| Bielecki, K | 1 |
| Kolodziejczak, M | 1 |
| Ezri, T | 1 |
| Susmallian, S | 1 |
| Utzig, MJ | 1 |
| Kroesen, AJ | 1 |
| Buhr, HJ | 1 |
| Vorozhtsova, IN | 1 |
| Bukhovets, IL | 1 |
| Bezliak, VV | 1 |
| Dudko, VA | 1 |
| Simpson, J | 1 |
| Lund, JN | 8 |
| Thompson, RJ | 1 |
| Kapila, L | 1 |
| Madalinski, M | 2 |
| Chaitman, BR | 2 |
| Pepine, CJ | 1 |
| Parker, JO | 4 |
| Skopal, J | 1 |
| Chumakova, G | 1 |
| Kuch, J | 1 |
| Wang, W | 1 |
| Skettino, SL | 1 |
| Wolff, AA | 1 |
| Crisafulli, A | 1 |
| Melis, F | 1 |
| Tocco, F | 1 |
| Santoboni, UM | 1 |
| Lai, C | 1 |
| Angioy, G | 1 |
| Lorrai, L | 1 |
| Pittau, G | 1 |
| Concu, A | 1 |
| Pagliaro, P | 1 |
| Appleyard, RC | 2 |
| Nelson, J | 2 |
| Takase, B | 1 |
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| Kurita, A | 1 |
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| Hauser, MF | 1 |
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| Ishfaq, T | 1 |
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| Courtier, R | 2 |
| Gil, MJ | 2 |
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| Puig, S | 2 |
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| Grande, L | 2 |
| Eddicks, S | 1 |
| Maier-Hauff, K | 1 |
| Schenk, M | 1 |
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| Theres, H | 1 |
| Brisinda, G | 2 |
| Cadeddu, F | 1 |
| Brandara, F | 1 |
| Marniga, G | 1 |
| Maria, G | 2 |
| Brown, CJ | 1 |
| Dubreuil, D | 1 |
| Santoro, L | 1 |
| Liu, M | 1 |
| O'Connor, BI | 1 |
| McLeod, RS | 1 |
| Benson, C | 1 |
| Seger, M | 1 |
| Voelker, J | 1 |
| Kelly, T | 1 |
| Ballal, M | 1 |
| Khera, G | 1 |
| Serrano, A | 1 |
| Shrivastava, UK | 1 |
| Jain, BK | 1 |
| Kumar, P | 1 |
| Saifee, Y | 1 |
| Dhawan, S | 1 |
| Chopra, S | 1 |
| Parissis, JT | 1 |
| Karavidas, A | 1 |
| Bistola, V | 1 |
| Arapi, S | 1 |
| Paraskevaidis, IA | 1 |
| Farmakis, D | 1 |
| Korres, D | 1 |
| Filippatos, G | 1 |
| Matsakas, E | 1 |
| Kremastinos, DT | 1 |
| Sato, M | 1 |
| Kurosawa, H | 1 |
| Itoh, T | 1 |
| Mizuno, Y | 1 |
| Harada, E | 1 |
| Yoshimura, M | 1 |
| Yasue, H | 1 |
| Bhardwaj, R | 1 |
| Parker, MC | 1 |
| Mele, A | 1 |
| Sica, G | 1 |
| Gentileschi, P | 1 |
| Di Carlo, S | 1 |
| Rimple, J | 1 |
| Cheek, E | 2 |
| Vijaynagar, B | 1 |
| Desai, M | 1 |
| McShane, JM | 1 |
| Ostick, B | 1 |
| McCabe, F | 1 |
| Petersson, M | 1 |
| Rundqvist, B | 1 |
| Bennett, BM | 1 |
| Adams, MA | 1 |
| Friberg, P | 1 |
| Lubowski, D | 1 |
| Emami, MH | 1 |
| Sayedyahossein, S | 1 |
| Aslani, A | 1 |
| Tancredi, RG | 1 |
| Jones, GR | 1 |
| Mir, MA | 1 |
| Bragina, GI | 2 |
| Pomerantsev, VP | 2 |
| Dorow, P | 1 |
| Tönnesmann, U | 1 |
| Kuz'ko, NV | 1 |
| Shteĭngardt, IuN | 1 |
| Tiukalova, LI | 1 |
| Markov, VA | 1 |
| Kun, VI | 1 |
| Tsymbaliuk, VP | 1 |
| Satinsky, JD | 1 |
| Olivari, MT | 1 |
| Carlyle, PF | 1 |
| Levine, TB | 1 |
| Cohn, JN | 1 |
| Pribylova, NN | 1 |
| Goloshchapov, OA | 1 |
| Parygina, EI | 1 |
| Kobuliia, BG | 1 |
| Kurashvili, RB | 1 |
| Kavtaradze, MN | 1 |
| Batkin, IZ | 1 |
| Molochnaia, EV | 1 |
| Daniliuk, VP | 1 |
| Davydova, FB | 1 |
| Lessem, J | 1 |
| Zhelnov, VV | 1 |
| Kapralova, TA | 1 |
| Giliarovskiĭ, AK | 1 |
| Le Pailleur, C | 1 |
| Baubion, N | 1 |
| Metzger, JP | 1 |
| Heulin, A | 1 |
| Vacheron, A | 1 |
| Di Matteo, J | 1 |
| Solonovich, TG | 1 |
| Halawa, B | 1 |
| Chatterjee, K | 5 |
| Parmley, WW | 2 |
| DiBianco, R | 1 |
| Singh, S | 1 |
| Singh, JB | 1 |
| Katz, RJ | 1 |
| Bortz, R | 1 |
| Gottdiener, JS | 1 |
| Spodick, DH | 1 |
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| Fletcher, RD | 1 |
| Agapova, EN | 2 |
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| Agabiti-Rosei, E | 3 |
| Bell, DR | 1 |
| Glasser, SP | 2 |
| Tei, C | 1 |
| Volkova, LI | 1 |
| Shteĭngart, IuN | 1 |
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| de Jongste, MJ | 1 |
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| Staal, MJ | 1 |
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| Lie, KI | 1 |
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| Boni, E | 1 |
| Castellano, M | 2 |
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| Cefis, G | 1 |
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| Verdecchia, P | 1 |
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| Jackson, G | 2 |
| Berger, Z | 1 |
| Pap, A | 1 |
| Geschwind, HJ | 1 |
| Dupouy, P | 1 |
| Dubois-Randé, JL | 1 |
| Zelinsky, R | 1 |
| Dávila-Román, VG | 1 |
| Creswell, LL | 1 |
| Rosenbloom, M | 1 |
| Pérez, JE | 1 |
| Cianfrocca, C | 1 |
| Sabia, R | 1 |
| Zoboli, S | 1 |
| Bugiardini, R | 1 |
| Roth, A | 2 |
| Shotan, A | 2 |
| Elkayam, U | 3 |
| Brzozowski, T | 1 |
| Konturek, SJ | 1 |
| Drozdowicz, D | 1 |
| Dembiński, A | 1 |
| Stachura, J | 1 |
| Parker, JD | 1 |
| Parker, AB | 1 |
| Farrell, B | 1 |
| Watson, SJ | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Topical 5% Minoxidil Versus 0.2%Topical Glyceryl Trinitrate in Treatment of Chronic Anal Fissure: a Randomized Controlled Trial[NCT03528772] | 62 participants (Actual) | Interventional | 2018-05-10 | Completed | |||
| Effectiveness of Stromal Vascular Fraction (SVF) and Platelets Rich Plasma (PRP) in Osteoarthritis and Tendinopathy: Study Protocol for a Phase III, Prospective, Randomized, Controlled Multi-center Study: (SPOT Study).[NCT05660824] | Phase 4 | 195 participants (Anticipated) | Interventional | 2023-06-30 | Not yet recruiting | ||
| Assessing and Comparing the Effect of Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers.[NCT02801305] | Phase 2 | 90 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| Randomized Controlled Trial Comparing the Efficacy of Polyethylene Glycol Alone and Polyethylene Glycol Combined With Topical Diltiazem in Treating Anal fissure in Children[NCT02419534] | Phase 4 | 46 participants (Anticipated) | Interventional | 2014-11-30 | Recruiting | ||
| Effects of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure[NCT04320498] | Phase 4 | 41 participants (Actual) | Interventional | 2019-01-01 | Completed | ||
| Comparative Evaluation of MEBO Ointment and Topical Diltiazem Ointment in the Treatment of Acute Anal Fissure: a Randomized Clinical Trial[NCT04153032] | Phase 2 | 183 participants (Anticipated) | Interventional | 2019-12-01 | Recruiting | ||
| A Randomized, Double-Blind, Placebo-Controlled Phase II Dose-Ranging Study of the OrthoDerm Transdermal Nitroglycerin Patch for Patients With Chronic Lateral Epicondylitis[NCT00447928] | Phase 2 | 164 participants | Interventional | 2007-04-30 | Not yet recruiting | ||
| A Single-center, Randomized, Double-blind, Placebo-controlled Study of the Efficacy and Safety of Allopurinol in Improving Ischemic Symptoms in Patients With Refractory Angina.[NCT04368819] | Phase 2/Phase 3 | 40 participants (Anticipated) | Interventional | 2021-03-03 | Recruiting | ||
| Allopurinol in the Treatment of Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease Treated by Either PCI or CABG: Pilot Study[NCT03700645] | Phase 4 | 100 participants (Anticipated) | Interventional | 2018-12-01 | Not yet recruiting | ||
| Perianal vs Endoanal Application of Glyceryl Trinitrate 0.4% Ointment in the Treatment of Chronic Anal Fissure: Results of a Randomized Controlled Trial.[NCT01132391] | Phase 3 | 60 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| The Use of Topical Glyceryl Trinitrate (GTN) and Eccentric Exercises in the Treatment of Midportion Achilles Tendinopathy: a Randomized Placebo Controlled Trial[NCT02499484] | 76 participants (Actual) | Interventional | 2016-09-30 | Completed | |||
| A Phase 4, Multiple-dose, Pharmacokinetic, Safety, and Exploratory Efficacy Study of Nitroglycerin Ointment 0.4% (RECTIV®) in Adolescents (Age ≥12 to <17 Years) With Moderate to Severe Pain Due to Chronic Anal Fissure[NCT01920074] | Phase 4 | 0 participants (Actual) | Interventional | 2013-06-30 | Withdrawn (stopped due to Study stopped due to study enrollment challenges that impacted the feasibility of conducting the study.) | ||
| Effect of Nitroglycerin Ointment on Mastectomy Flap Necrosis[NCT01608880] | 154 participants (Actual) | Interventional | 2012-08-31 | Completed | |||
| A Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of Ranolazine SR at a Dose of 1000 mg Twice a Day in Patients With Chronic Angina Who Remain Symptomatic Despite Treatment With Amlodipine 10 mg Once a Day[NCT00091429] | Phase 3 | 500 participants | Interventional | 2004-08-31 | Completed | ||
| Effect of Ranolazine on Activity Level in Patients With Angina After FFR Based Deferred Intervention[NCT03044964] | Phase 4 | 40 participants (Anticipated) | Interventional | 2017-01-10 | Recruiting | ||
| Idiopathic Hypertensive Anal Canal: a Place of Internal Sphincterotomy[NCT00927849] | 63 participants (Actual) | Interventional | 2002-09-30 | Completed | |||
| Botulin Toxin Versus Isosorbidedinitrate Ointment in Treatment Anal Fissure; A Prospective, Blinded, Randomized Trial[NCT00827736] | Phase 4 | 73 participants (Actual) | Interventional | 2002-06-30 | Completed | ||
| Vitamin C Supplementation Intervention for Patients With Heart Failure-A Pilot Study[NCT04036110] | 36 participants (Actual) | Interventional | 2018-08-14 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
using a visual analog scale (VAS) with which each patients noted the severity of pain at each evaluated time using a linear between zero (no pain) and 10 ( severe pain) (NCT00927849)
Timeframe: one year after the procedure
| Intervention | score in scale (Mean) |
|---|---|
| Surgical Group Lateral Sphincterotomy | 4.16 |
| Glycein Trinitrate Group | 4.18 |
| Botilinium Toxin Injection | 4.2 |
The ELISA (enzyme-linked immunosorbent assay) used to detect and quantify Vitamin C in serum (NCT04036110)
Timeframe: Baseline
| Intervention | ng/mL (Mean) |
|---|---|
| Intervention 1 (500 mg) | 13372 |
| Intervention 2 (1000 mg) | 16079 |
| Control (Placebo) | 13111 |
The ELISA (enzyme-linked immunosorbent assay) used to detect and quantify Vitamin C in serum (NCT04036110)
Timeframe: Month 3
| Intervention | ng/mL (Mean) |
|---|---|
| Intervention 1 (500 mg) | 21309 |
| Intervention 2 (1000 mg) | 20574 |
| Control (Placebo) | 12537 |
The MindWare Mobile impedance cardiograph (model number 50-2303-00) used to measure participant's cardiac function using the parameter of cardiac output. Measured at Baseline and Month 3. (NCT04036110)
Timeframe: Baseline and up to 3 months after enrollment
| Intervention | L/min (Mean) | |
|---|---|---|
| Baseline | Month 3 | |
| Control (Placebo) | 5.6 | 14.2 |
| Intervention 1 (500 mg) | 6.9 | 12.7 |
Health related quality of life is measured using the Minnesota Living with Heart Failure questionnaire (MLHFQ). The MLHFQ is a patient-reported outcome to measure the patient's perceptions of the influence of heart failure on physical and emotional aspects of life. The questionnaire has 21 items to assess the impact of frequent physical symptoms of heart failure and the effects of heart failure on physical and emotional functions. The response scale for all 21 items on the MLHFQ is based on a 6-point (from 0 to 5). Scores are summed to a range of 0-105, in which with higher scores indicate worse health-related quality of life. Measured at Baseline and Month 3. (NCT04036110)
Timeframe: Baseline and up to 3 months after enrollment
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Baseline | Month 3 | |
| Control (Placebo) | 44.2 | 27.6 |
| Intervention 1 (500 mg) | 45.3 | 68.2 |
| Intervention 2 (1000 mg) | 31.4 | 47.4 |
The ELISA (enzyme-linked immunosorbent assay) used to detect and quantify 8-iso-PGF2a isoprostane in serum to reflect oxidative stress. Measured at Baseline and Month 3. (NCT04036110)
Timeframe: Baseline and up to 3 months after enrollment
| Intervention | pg/mL (Mean) | |
|---|---|---|
| Baseline | 3 months | |
| Control (Placebo) | 13832 | 2580 |
| Intervention 1 (500 mg) | 23144 | 507 |
| Intervention 2 (1000 mg) | 10406 | 2431 |
Symptom burden is measured using items from the Memorial Symptom Assessment Scale-Heart Failure (MSAS-HF). The MSAS-HF is an 8-item questionnaire to measure HF symptoms experienced by patients with HF. Patients will be first asked if the symptom was present during the previous 7 days. If present, three characteristics of each symptom will be rated: frequency of symptom, severity of symptom, and degree of symptom distress. Frequency is rated on a scale from 0 to 5 (1=no symptom to 5=all the time), severity rated on a scale from 0 to 5 (0=not at all to 5=extremely) and distress rated on a scale from 0 to 5 (0=not at all to 5=extremely). Burden score for each symptom can range from 0 (no burden) to 4 (greatest symptom frequency, severity, and distress). The total MAS-HF scores are summed to a range of 0-180, with higher scores indicating higher symptom burden. Measured at Baseline and Month 3. (NCT04036110)
Timeframe: Baseline and up to 3 months after enrollment
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Baseline | Month 3 | |
| Control (Placebo) | 31.2 | 20.1 |
| Intervention 1 (500 mg) | 47.5 | 24.5 |
| Intervention 2 (1000 mg) | 20.2 | 24.8 |
43 reviews available for nitroglycerin and Chronic Disease
| Article | Year |
|---|---|
A systematic review and meta-analysis of the efficacy of topical sphincterotomy treatments for anal fissure.
Topics: Administration, Topical; Chronic Disease; Diltiazem; Fissure in Ano; Humans; Nitroglycerin; Sphincte | 2022 |
Clinical Outcomes of Medical Management Options for Chronic Anal Fissures in a Long-Term Follow-up: Systematic Review and Meta-Analysis.
Topics: Adult; Chronic Disease; Fissure in Ano; Glycerol; Humans; Nifedipine; Nitroglycerin; Treatment Outco | 2023 |
A review of interventions to reduce pain in chronic wounds.
Topics: Anesthetics, Local; Apitherapy; Bandages; Chronic Disease; Chronic Pain; Collagen; Community Health | 2019 |
Management of Chronic Tendon Injuries.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cryotherapy; Exer | 2019 |
Efficacy of spinal cord stimulation as an adjunct therapy for chronic refractory angina pectoris.
Topics: Aged; Angina Pectoris; Chronic Disease; Combined Modality Therapy; Exercise Tolerance; Female; Human | 2017 |
Recent advances in the pharmacotherapy of chronic anal fissure: an update.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel | 2008 |
Recent advances in the pharmacotherapy of chronic anal fissure: an update.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel | 2008 |
Recent advances in the pharmacotherapy of chronic anal fissure: an update.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel | 2008 |
Recent advances in the pharmacotherapy of chronic anal fissure: an update.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel | 2008 |
Five-year prospective comparison study of topical glyceryl trinitrate treatment of chronic lateral epicondylosis at the elbow.
Topics: Administration, Topical; Adult; Aged; Chronic Disease; Follow-Up Studies; Humans; Male; Middle Aged; | 2011 |
Anal fissure.
Topics: Acute Disease; Anal Canal; Botulinum Toxins, Type A; Calcium Channel Blockers; Chronic Disease; Dilt | 2010 |
Ranolazine: an anti-anginal drug with further therapeutic potential.
Topics: Acetanilides; Angina Pectoris; Chronic Disease; Dose-Response Relationship, Drug; Drug Administratio | 2010 |
Evidence on the effectiveness of topical nitroglycerin in the treatment of tendinopathies: a systematic review and meta-analysis.
Topics: Acute Disease; Administration, Cutaneous; Chronic Disease; Clinical Trials as Topic; Humans; Nitrogl | 2010 |
The management of patients with primary chronic anal fissure: a position paper.
Topics: Anal Canal; Botulinum Toxins; Calcium Channel Blockers; Chronic Disease; Fissure in Ano; Humans; Nit | 2011 |
Systematic review of the use of topical diltiazem compared with glyceryltrinitrate for the nonoperative management of chronic anal fissure.
Topics: Administration, Topical; Chronic Disease; Diltiazem; Fissure in Ano; Headache; Humans; Nitroglycerin | 2013 |
[Treatment of chronic anal fissure with topically applied nitroglycerin ointment. A systematic review of evidence-based results].
Topics: Administration, Topical; Anal Canal; Chronic Disease; Evidence-Based Medicine; Fissure in Ano; Heada | 2002 |
A study to determine the nitroglycerin ointment dose and dosing interval that best promote the healing of chronic anal fissures.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Double-Blind Method; Drug Administration Schedule; | 2002 |
The medical and surgical management of chronic anal fissure.
Topics: Adrenergic alpha-Antagonists; Botulinum Toxins, Type A; Calcium Channel Blockers; Chronic Disease; F | 2002 |
Concepts in pathogenesis and treatment of chronic anal fissure--a review of the literature.
Topics: Administration, Topical; Anti-Dyskinesia Agents; Botulinum Toxins; Calcium Channel Blockers; Chronic | 2003 |
Chemical sphincterotomy--first line of treatment for chronic anal fissure.
Topics: Botulinum Toxins; Calcium Channel Blockers; Chronic Disease; Diltiazem; Fissure in Ano; Humans; Isos | 2005 |
Pharmacological advancements in the treatment of chronic anal fissure.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Albuterol; Botulinu | 2005 |
0.4% nitroglycerin ointment : in the treatment of chronic anal fissure pain.
Topics: Administration, Topical; Chronic Disease; Drug Administration Schedule; Fissure in Ano; Humans; Nitr | 2006 |
Nonsurgical approaches for the treatment of anal fissures.
Topics: Anal Canal; Botulinum Toxins; Chronic Disease; Diltiazem; Fissure in Ano; Humans; Muscle Relaxation; | 2007 |
[Respiratory management of acute and chronic heart failure].
Topics: Acute Disease; Chronic Disease; Diagnosis, Differential; Heart Failure; Humans; Morphine; Nitroglyce | 2007 |
Modern perspectives in the treatment of chronic anal fissures.
Topics: Botulinum Toxins; Chronic Disease; Diltiazem; Fissure in Ano; Humans; Nitric Oxide Donors; Nitroglyc | 2007 |
The efficacy of diltiazem and glyceryltrinitrate for the medical management of chronic anal fissure: a meta-analysis.
Topics: Chronic Disease; Diltiazem; Fissure in Ano; Headache; Humans; Nitroglycerin; Prospective Studies; Ra | 2008 |
Botulinum toxin vs glyceryltrinitrate for the medical management of chronic anal fissure: a meta-analysis.
Topics: Anti-Dyskinesia Agents; Botulinum Toxins; Chronic Disease; Female; Fissure in Ano; Humans; Male; Nit | 2008 |
Noninsertional Achilles tendinopathy: pathology and management.
Topics: Achilles Tendon; Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Di | 2007 |
Medical management of patients with chronic stable angina pectoris.
Topics: Adrenergic beta-Antagonists; Adult; Angina Pectoris; Chronic Disease; Clinical Laboratory Techniques | 1980 |
[Drug treatment of chronic coronary disease].
Topics: Chronic Disease; Coronary Circulation; Coronary Disease; Humans; Isosorbide Dinitrate; Myocardium; N | 1980 |
Vasodilator therapy for chronic heart failure.
Topics: Captopril; Chronic Disease; Heart Failure; Hemodynamics; Humans; Hydralazine; Nitrates; Nitroglyceri | 1980 |
Nisoldipine coat core as concomitant therapy in chronic stable angina pectoris.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Chronic Disease; Delayed-Action Preparations; Drug The | 1995 |
Assessment of myocardial viability in chronic left ventricular dysfunction.
Topics: Chronic Disease; Deoxyglucose; Dobutamine; Echocardiography; Fluorine Radioisotopes; Fluorodeoxygluc | 1995 |
The role of nitroglycerin preparations in the treatment of post-acute and chronic pancreatitis.
Topics: Acute Disease; Ampulla of Vater; Blood Glucose; Calcium Channel Blockers; Cholecystokinin; Chronic D | 1993 |
A nonsurgical approach to chronic anal fissure.
Topics: Administration, Topical; Chronic Disease; Fissure in Ano; Humans; Nitroglycerin; Pain; Risk Factors; | 1997 |
Fissure-in-ano, to divide or not to divide?
Topics: Algorithms; Anti-Dyskinesia Agents; Botulinum Toxins; Chronic Disease; Fissure in Ano; Humans; Nitro | 1999 |
Cut or paste? The use of glyceryl trinitrate paste in the treatment of acute and chronic anal fissure.
Topics: Acute Disease; Chronic Disease; Combined Modality Therapy; Fissure in Ano; Humans; Nitroglycerin; Oi | 2000 |
Anal fissures.
Topics: Chronic Disease; Constipation; Dietary Fiber; Digestive System Surgical Procedures; Fissure in Ano; | 2000 |
Progress in the understanding and treatment of chronic anal fissure.
Topics: Administration, Topical; Anal Canal; Botulinum Toxins; Calcium Channel Blockers; Chronic Disease; Di | 2001 |
[Nitric oxide donors and their potentiating effects after botulinum toxin application for treatment of chronic anal fissure].
Topics: Administration, Topical; Botulinum Toxins; Chronic Disease; Drug Synergism; Fissure in Ano; Humans; | 2002 |
Afterload reduction and cardiac performance. Physiologic basis of systemic vasodilators as a new approach in treatment of congestive heart failure.
Topics: Aorta; Cardiac Output; Chronic Disease; Heart; Heart Failure; Heart Ventricles; Hemodynamics; Humans | 1978 |
[Vasodilator therapy of congestive heart failure].
Topics: Acute Disease; Blood Pressure; Cardiac Output; Chronic Disease; Heart Failure; Humans; Isosorbide Di | 1977 |
Left ventricular function in acute and chronic coronary artery disease.
Topics: Acute Disease; Angiocardiography; Blood Pressure Determination; Cardiac Catheterization; Cardiac Out | 1975 |
Nitrate therapy in heart failure.
Topics: Administration, Cutaneous; Chronic Disease; Drug Administration Schedule; Heart Failure; Humans; Inf | 1991 |
[Clinical characteristics of cluster headache].
Topics: Chronic Disease; Cluster Headache; Humans; Nitroglycerin; Pulse; Vascular Headaches | 1989 |
[Use of nitroglycerin in the treatment of congestive heart failure].
Topics: Chronic Disease; Heart Failure; Hemodynamics; Humans; Myocardial Contraction; Nitroglycerin | 1989 |
116 trials available for nitroglycerin and Chronic Disease
| Article | Year |
|---|---|
Clinical Outcome of 0.2% Glyceryl Trinitrate Topical Ointment Compared to Lateral Internal Sphincterotomy in the Treatment of Patient with Chronic Anal Fissure: A Randomized Control Trial.
Topics: Administration, Topical; Adult; Anal Canal; Chronic Disease; Female; Fissure in Ano; Humans; Lateral | 2022 |
Efficacy and safety of Propionibacterium extract gel versus glyceryl trinitrate ointment in the treatment of chronic anal fissure: a randomized controlled trial.
Topics: Administration, Topical; Chronic Disease; Fissure in Ano; Humans; Nitroglycerin; Ointments; Propioni | 2023 |
Topical 5% minoxidil versus topical 0.2% glyceryl trinitrate in treatment of chronic anal fissure: A randomized clinical trial.
Topics: Administration, Topical; Adult; Chronic Disease; Female; Fissure in Ano; Humans; Male; Middle Aged; | 2020 |
Comparative efficacy of medical treatment versus surgical sphincterotomy in the treatment of chronic anal fissure.
Topics: Chronic Disease; Diltiazem; Fissure in Ano; Humans; Nitroglycerin; Pain Management; Quality of Life; | 2020 |
Short-term Results of Platelet-Rich Plasma in the Treatment of Chronic Anal Fissure: Randomized Controlled Clinical Study.
Topics: Acetylcholine Release Inhibitors; Adult; Botulinum Toxins; Case-Control Studies; Chronic Disease; Fe | 2021 |
Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double-blind trial.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Diltiazem; Dou | 2012 |
Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double-blind trial.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Diltiazem; Dou | 2012 |
Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double-blind trial.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Diltiazem; Dou | 2012 |
Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double-blind trial.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Diltiazem; Dou | 2012 |
Internal sphincterotomy versus topical nitroglycerin ointment for chronic anal fissure.
Topics: Administration, Topical; Anal Canal; Chronic Disease; Female; Fissure in Ano; Humans; Male; Nitrogly | 2014 |
Botulinum toxin versus botulinum toxin with low-dose glyceryltrinitrate for healing of chronic anal fissure: a prospective, randomised trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Dyskinesia Agents; Botulinum Toxins; Chronic Diseas | 2014 |
Maintenance therapy with partially hydrolyzed guar gum in the conservative treatment of chronic anal fissure: results of a prospective, randomized study.
Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Aged; Chronic Disease; Dietary Sup | 2014 |
Chronic Anal Fissure: A Comparative Study of Medical Treatment Versus Surgical Sphincterotomy.
Topics: Administration, Topical; Adult; Aged; Anal Canal; Chronic Disease; Digestive System Surgical Procedu | 2016 |
Percutaneous Posterior Tibial Nerve Stimulation vs Perianal Application of Glyceryl Trinitrate Ointment in the Treatment of Chronic Anal Fissure: A Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Chronic Disease; Electric Stimulation Therapy; Female; Fissure in An | 2017 |
Comparative study of lateral internal sphincterotomy versus local 0.2% glyceryl trinitrate ointment for the treatment of chronic anal fissure.
Topics: Adolescent; Adult; Chronic Disease; Digestive System Surgical Procedures; Female; Fissure in Ano; Hu | 2008 |
Randomised, double-blind, placebo-controlled clinical trial of a new topical glyceryl trinitrate patch for chronic lateral epicondylosis.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Analgesics; Chronic Disease; Dose-Response Relat | 2009 |
Glyceryl trinitrate ointment (0.25%) and anal cryothermal dilators in the treatment of chronic anal fissures.
Topics: Administration, Topical; Adolescent; Adult; Anal Canal; Chronic Disease; Cryotherapy; Dilatation; Fe | 2009 |
Topical diltiazem hydrochloride and glyceryl trinitrate in the treatment of chronic anal fissure.
Topics: Calcium Channel Blockers; Chronic Disease; Diltiazem; Female; Fissure in Ano; Humans; Male; Nitrogly | 2009 |
Long-term prospective randomised clinical and manometric comparison between surgical and chemical sphincterotomy for treatment of chronic anal fissure.
Topics: Adolescent; Adult; Aged; Anal Canal; Botulinum Toxins; Calcium Channel Blockers; Chronic Disease; Di | 2009 |
Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Angina Pectoris; Blood Pressure; C-Reactive | 2010 |
Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Angina Pectoris; Blood Pressure; C-Reactive | 2010 |
Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Angina Pectoris; Blood Pressure; C-Reactive | 2010 |
Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Allopurinol; Angina Pectoris; Blood Pressure; C-Reactive | 2010 |
Optimal treatment duration of glyceryl trinitrate for chronic anal fissure: results of a prospective randomized multicenter trial.
Topics: Administration, Topical; Adult; Analysis of Variance; Chronic Disease; Dose-Response Relationship, D | 2010 |
Perianal versus endoanal application of glyceryl trinitrate 0.4% ointment in the treatment of chronic anal fissure: results of a randomized controlled trial. Is this the solution to the headaches?
Topics: Adolescent; Adult; Aged; Chronic Disease; Drug Administration Schedule; Female; Fissure in Ano; Foll | 2012 |
[Tolerability and efficiency of a new transdermic nitroglycerin patch in outpatients with chronic stable angina. The PATRICH Trial].
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care; Angina Pecto | 2002 |
A study to determine the nitroglycerin ointment dose and dosing interval that best promote the healing of chronic anal fissures.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Double-Blind Method; Drug Administration Schedule; | 2002 |
Randomised trial of topical 0.2% glyceryl trinitrate and lateral internal sphincterotomy for the treatment of patients with chronic anal fissure: long-term follow-up.
Topics: Administration, Topical; Adolescent; Adult; Chronic Disease; Confidence Intervals; Female; Fissure i | 2002 |
A dose finding study with 0.1%, 0.2%, and 0.4% glyceryl trinitrate ointment in patients with chronic anal fissures.
Topics: Adult; Anal Canal; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Female; F | 2003 |
Botulinum toxin as second-line therapy for chronic anal fissure failing 0.2 percent glyceryl trinitrate.
Topics: Adult; Aged; Aged, 80 and over; Anal Canal; Botulinum Toxins; Chronic Disease; Female; Fissure in An | 2003 |
A prospective randomized trial of diltiazem and glyceryltrinitrate ointment in the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Aged; Chronic Disease; Diltiazem; Female; Fissure in Ano; Humans; Ma | 2003 |
Topical nifedipine vs. topical glyceryl trinitrate for treatment of chronic anal fissure.
Topics: Calcium Channel Blockers; Chronic Disease; Double-Blind Method; Female; Humans; Male; Nifedipine; Ni | 2003 |
The use of glyceryl trinitrate (GTN) in the treatment of chronic anal fissure in children.
Topics: Adolescent; Child; Child, Preschool; Chronic Disease; Female; Fissure in Ano; Humans; Male; Nitrogly | 2003 |
Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial.
Topics: Acetanilides; Adrenergic beta-Antagonists; Aged; Amlodipine; Angina Pectoris; Atenolol; Calcium Chan | 2004 |
Exercise-induced and nitroglycerin-induced myocardial preconditioning improves hemodynamics in patients with angina.
Topics: Angina Pectoris; Cardiography, Impedance; Chronic Disease; Exercise; Hemodynamics; Humans; Ischemic | 2004 |
Topical glyceryl trinitrate treatment of chronic noninsertional achilles tendinopathy. A randomized, double-blind, placebo-controlled trial.
Topics: Achilles Tendon; Administration, Topical; Adult; Aged; Chronic Disease; Double-Blind Method; Female; | 2004 |
A randomised study comparing systemic transdermal treatment and local application of glyceryl trinitrate ointment in the management of chronic anal fissure.
Topics: Administration, Cutaneous; Administration, Topical; Adult; Chronic Disease; Female; Fissure in Ano; | 2003 |
Hydropneumatic anal dilation in conservative treatment of chronic anal fissure: clinical outcomes and randomized comparison with topical nitroglycerin.
Topics: Administration, Topical; Catheterization; Chronic Disease; Feasibility Studies; Female; Fissure in A | 2004 |
Manometric effect of topical glyceryl trinitrate and its impact on chronic anal fissure healing.
Topics: Administration, Topical; Adult; Aged; Anal Canal; Chronic Disease; Drug Administration Schedule; Fem | 2005 |
Topical glyceryl trinitrate application in the treatment of chronic supraspinatus tendinopathy: a randomized, double-blinded, placebo-controlled clinical trial.
Topics: Administration, Topical; Adult; Aged; Chronic Disease; Double-Blind Method; Female; Humans; Male; Mi | 2005 |
Effects of ranolazine on exercise tolerance and HbA1c in patients with chronic angina and diabetes.
Topics: Acetanilides; Aged; Angina Pectoris; Chronic Disease; Diabetic Angiopathies; Double-Blind Method; En | 2006 |
Comparison of glycerine trinitrate and botulinum toxin-a for the treatment of chronic anal fissure: long-term results.
Topics: Adult; Aged; Botulinum Toxins, Type A; Chronic Disease; Female; Fissure in Ano; Follow-Up Studies; H | 2006 |
Efficacy and safety of botulinum toxin a injection compared with topical nitroglycerin ointment for the treatment of chronic anal fissure: a prospective randomized study.
Topics: Administration, Topical; Adult; Aged; Botulinum Toxins, Type A; Chronic Disease; Drug Therapy, Combi | 2006 |
Antianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (Efficacy of Ranolazine in Chronic Angina) trial.
Topics: Acetanilides; Aged; Amlodipine; Angina Pectoris; Chronic Disease; Coronary Disease; Double-Blind Met | 2006 |
Antianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (Efficacy of Ranolazine in Chronic Angina) trial.
Topics: Acetanilides; Aged; Amlodipine; Angina Pectoris; Chronic Disease; Coronary Disease; Double-Blind Met | 2006 |
Antianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (Efficacy of Ranolazine in Chronic Angina) trial.
Topics: Acetanilides; Aged; Amlodipine; Angina Pectoris; Chronic Disease; Coronary Disease; Double-Blind Met | 2006 |
Antianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (Efficacy of Ranolazine in Chronic Angina) trial.
Topics: Acetanilides; Aged; Amlodipine; Angina Pectoris; Chronic Disease; Coronary Disease; Double-Blind Met | 2006 |
Randomized, prospective trial comparing 0.25 percent glycerin trinitrate ointment and anal cryothermal dilators only with 0.25 percent glycerin trinitrate ointment and only with anal cryothermal dilators in the treatment of chronic anal fissure: a two-yea
Topics: Adolescent; Adult; Chronic Disease; Cryotherapy; Dilatation; Female; Fissure in Ano; Follow-Up Studi | 2006 |
Endosonographic and manometric evaluation of internal anal sphincter in patients with chronic anal fissure and its correlation with clinical outcome after topical glyceryl trinitrate therapy.
Topics: Administration, Topical; Adult; Anal Canal; Chronic Disease; Endosonography; Female; Fissure in Ano; | 2007 |
Thoracic spinal cord stimulation improves functional status and relieves symptoms in patients with refractory angina pectoris: the first placebo-controlled randomised study.
Topics: Aged; Angina Pectoris; Chronic Disease; Electric Stimulation Therapy; Exercise Test; Female; Follow- | 2007 |
Randomized clinical trial comparing botulinum toxin injections with 0.2 per cent nitroglycerin ointment for chronic anal fissure.
Topics: Administration, Topical; Adult; Botulinum Toxins, Type A; Chronic Disease; Female; Fissure in Ano; F | 2007 |
Lateral internal sphincterotomy is superior to topical nitroglycerin for healing chronic anal fissure and does not compromise long-term fecal continence: six-year follow-up of a multicenter, randomized, controlled trial.
Topics: Administration, Topical; Adult; Anal Canal; Chronic Disease; Female; Fissure in Ano; Follow-Up Studi | 2007 |
Inhibition of PKC beta by ruboxistaurin does not enhance the acute blood pressure response to nitroglycerin.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Aged; Angina Pectoris; Blood Pressure; Chronic Di | 2007 |
A comparison of the effects of diltiazem and glyceryl trinitrate ointment in the treatment of chronic anal fissure: a randomized clinical trial.
Topics: Administration, Topical; Adolescent; Adult; Chronic Disease; Diltiazem; Female; Fissure in Ano; Huma | 2007 |
Effects of levosimendan on flow-mediated vasodilation and soluble adhesion molecules in patients with advanced chronic heart failure.
Topics: Aged; Chronic Disease; Endothelium, Vascular; Female; Heart Failure; Humans; Hydrazones; Intercellul | 2008 |
Coronary spasm is associated with chronic low-grade inflammation.
Topics: Acetylcholine; Aged; Biomarkers; C-Reactive Protein; Case-Control Studies; Chest Pain; Chronic Disea | 2007 |
Medical and surgical treatment of chronic anal fissure: a prospective study.
Topics: Adult; Botulinum Toxins; Chronic Disease; Dilatation; Female; Fissure in Ano; Humans; Male; Nitrogly | 2007 |
Three-year followup study of topical glyceryl trinitrate treatment of chronic noninsertional Achilles tendinopathy.
Topics: Achilles Tendon; Administration, Topical; Adult; Aged; Chronic Disease; Double-Blind Method; Female; | 2007 |
Safety and efficacy of new glyceryl trinitrate suppository formula: first double blind placebo-controlled clinical trial.
Topics: Abietanes; Adolescent; Adult; Chronic Disease; Colonoscopy; Cross-Over Studies; Double-Blind Method; | 2008 |
Comparison of antianginal efficacy of one conventional and three long acting beta-adrenoreceptor blocking agents in stable angina pectoris.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Chronic Disease; Clinical Trials as Topic | 1981 |
Comparison of slow-release pindolol, standard pindolol, and propranolol in angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Chronic Disease; Clinical Trials as Topic; Delayed-Action Preparations | 1983 |
Combined therapy with Ca-antagonists and beta-adrenergic receptor blocking agents in chronic stable angina.
Topics: Adult; Aged; Angina Pectoris; Atenolol; Blood Pressure; Chronic Disease; Drug Therapy, Combination; | 1984 |
Effects of acebutolol on chronic stable angina pectoris. A placebo-controlled, double-blind, randomized crossover study.
Topics: Acebutolol; Aged; Angina Pectoris; Blood Pressure; Chronic Disease; Double-Blind Method; Drug Evalua | 1980 |
[Changes in intracardiac hemodynamics and the tolerance for physical loading as affected by Nitrong in persons suffering from ischemic heart disease].
Topics: Adult; Angina Pectoris; Chronic Disease; Clinical Trials as Topic; Coronary Disease; Double-Blind Me | 1981 |
[Treatment of patients with angina pectoris in general practice with a new transdermal therapeutic system containing nitroglycerin (author's transl)].
Topics: Adult; Aged; Angina Pectoris; Chronic Disease; Clinical Trials as Topic; Female; Humans; Male; Middl | 1982 |
[Sustak pharmacodynamics in effort stenocardia].
Topics: Adult; Angina Pectoris; Chronic Disease; Drug Evaluation; Exercise Test; Hemodynamics; Humans; Male; | 1982 |
Antianginal effect of transdermal nitroglycerin and oral nitrates given for 24 hours a day in 2,456 patients with stable angina pectoris. The Italian Multicenter Study.
Topics: Administration, Cutaneous; Administration, Oral; Aged; Angina Pectoris; Chronic Disease; Circadian R | 1995 |
Effects of transdermal nitroglycerin in combination with an ACE inhibitor in patients with chronic stable angina pectoris.
Topics: Administration, Cutaneous; Aged; Aldosterone; Angina Pectoris; Angiotensin-Converting Enzyme Inhibit | 1993 |
Efficacy of intermittent (eight hours off) transdermal nitrate therapy in stable angina.
Topics: Administration, Cutaneous; Aged; Angina Pectoris; Blood Pressure; Chronic Disease; Double-Blind Meth | 1994 |
[The development of tolerance to continuous transdermal nitroglycerin therapy in patients with angina of effort and mixed angina].
Topics: Administration, Cutaneous; Administration, Sublingual; Adult; Angina Pectoris; Chronic Disease; Drug | 1993 |
A randomized comparison between the hemodynamic effects of hydralazine and nitroglycerin alone and in combination at rest and during isometric exercise in patients with chronic mitral regurgitation.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Chronic Disease; Drug Therapy, Combination; Exercise; | 1993 |
Effects of diuretic therapy on the development of tolerance to nitroglycerin and exercise capacity in patients with chronic stable angina.
Topics: Administration, Cutaneous; Amiloride; Angina Pectoris; Blood Pressure; Chronic Disease; Cross-Over S | 1996 |
Treatment of hypertension associated with stable angina pectoris: favourable interaction between new metoprolol formulation (OROS) and nifedipine.
Topics: Angina Pectoris; Antihypertensive Agents; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blo | 1996 |
A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure.
Topics: Administration, Topical; Chronic Disease; Double-Blind Method; Fissure in Ano; Humans; Nitroglycerin | 1997 |
Glyceryl trinitrate is an effective treatment for anal fissure.
Topics: Administration, Cutaneous; Adolescent; Adult; Chronic Disease; Female; Fissure in Ano; Humans; Male; | 1997 |
Carvedilol versus verapamil in chronic stable angina: a multicentre trial.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Carbaz | 1997 |
Effects of nicorandil, an antianginal potassium channel opener, on left ventricular systolic and diastolic function in patients with chronic coronary artery disease.
Topics: Adult; Aged; Chronic Disease; Coronary Disease; Diastole; Female; Humans; Male; Middle Aged; Niacina | 1997 |
Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy?
Topics: Acute Disease; Administration, Rectal; Administration, Topical; Adult; Anal Canal; Anesthetics, Loca | 1997 |
Mibefradil in the treatment of chronic stable angina pectoris: comparative studies with other calcium antagonists.
Topics: Adult; Aged; Aged, 80 and over; Amlodipine; Angina Pectoris; Benzimidazoles; Calcium Channel Blocker | 1997 |
[Nitric oxide: its role in the development of pregnancy complications and in their prevention in women with hypertension and chronic glomerulonephritis].
Topics: Administration, Cutaneous; Adult; Chronic Disease; Female; Glomerulonephritis; Humans; Hypertension; | 1997 |
The nature and importance of changes in toe-brachial pressure indices following percutaneous transluminal angioplasty for leg ischaemia.
Topics: Aged; Angioplasty, Balloon; Ankle; Blood Pressure; Brachial Artery; Chronic Disease; Combined Modali | 1997 |
Glyceryl trinitrate vs. sphincterotomy for treatment of chronic fissure-in-ano: a randomized, controlled trial.
Topics: Administration, Topical; Adult; Aged; Anal Canal; Chronic Disease; Female; Fissure in Ano; Follow-Up | 1997 |
Preventive effects of angiotensin-converting enzyme inhibitors on nitrate tolerance during continuous transdermal application of nitroglycerin in patients with chronic heart failure.
Topics: Administration, Cutaneous; Aged; Angiotensin-Converting Enzyme Inhibitors; Atrial Natriuretic Factor | 1998 |
Additional antianginal and anti-ischemic efficacy of mibefradil in patients concomitantly treated with long-acting nitrates for chronic stable angina pectoris.
Topics: Adolescent; Adult; Aged; Angina Pectoris; Benzimidazoles; Calcium Channel Blockers; Chronic Disease; | 1998 |
A comparative study of eccentric and concentric coronary stenosis vasomotion in patients with Prinzmental's variant angina and patients with stable angina pectoris.
Topics: Adult; Angina Pectoris; Angina Pectoris, Variant; Blood Pressure; Chronic Disease; Coronary Angiogra | 1998 |
Randomized, double-blind, placebo-controlled study of carvedilol on the prevention of nitrate tolerance in patients with chronic heart failure.
Topics: Adrenergic Antagonists; Aged; Blood Flow Velocity; Blood Platelets; Blood Pressure; Carbazoles; Carv | 1998 |
[Study of the general and topical tolerance of Trinipatch and its clinical efficacy in the therapy of chronic stable angina in 5078 coronary disease patients].
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Chronic Disease; Coronary Disease; Dose-Response Re | 1998 |
Randomised controlled trial shows that glyceryl trinitrate heals anal fissures, higher doses are not more effective, and there is a high recurrence rate.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Meth | 1999 |
Double-blind, placebo-controlled study to evaluate the effect of organic nitrates in patients with chronic heart failure treated with angiotensin-converting enzyme inhibition.
Topics: Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Cardiac Output, Low; Chronic Disease; Cros | 1999 |
A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Anal Canal; Botulinum Toxins, Type A; Chronic Disease; Cross-Over St | 1999 |
A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Anal Canal; Botulinum Toxins, Type A; Chronic Disease; Cross-Over St | 1999 |
A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Anal Canal; Botulinum Toxins, Type A; Chronic Disease; Cross-Over St | 1999 |
A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Anal Canal; Botulinum Toxins, Type A; Chronic Disease; Cross-Over St | 1999 |
Lateral internal sphincterotomy is not redundant in the era of glyceryl trinitrate therapy for chronic anal fissure.
Topics: Adult; Aged; Chronic Disease; Female; Fissure in Ano; Follow-Up Studies; Humans; Male; Middle Aged; | 1999 |
Glyceryl trinitrate ointment for the treatment of chronic anal fissure: results of a placebo-controlled trial and long-term follow-up.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Chronic Disease; Double-Blind Method; Femal | 1999 |
Glyceryl trinitrate for chronic anal fissure--healing or headache? Results of a multicenter, randomized, placebo-controled, double-blind trial.
Topics: Adult; Anal Canal; Blood Flow Velocity; Chronic Disease; Double-Blind Method; Female; Fissure in Ano | 2000 |
Audit of topical glyceryl trinitrate for treatment of fissure-in-ano.
Topics: Acute Disease; Adult; Aged; Chronic Disease; Female; Fissure in Ano; Follow-Up Studies; Headache; Hu | 2000 |
Glyceryl trinitrate treatment of chronic fissure in ano: one year's experience with 0.5% GTN paste.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Drug Administr | 2000 |
Nitric oxide-induced headache in patients with chronic tension-type headache.
Topics: Adult; Chronic Disease; Cross-Over Studies; Double-Blind Method; Female; Hemodynamics; Humans; Male; | 2000 |
A randomized trial of glyceryl trinitrate ointment and nitroglycerin patch in healing of anal fissures.
Topics: Administration, Cutaneous; Adult; Chronic Disease; Female; Fissure in Ano; Humans; Male; Middle Aged | 2000 |
Glyceryl trinitrate for fissures: patch or paste?
Topics: Administration, Cutaneous; Anal Canal; Chronic Disease; Fissure in Ano; Humans; Manometry; Nitroglyc | 2000 |
The pharmacokinetics of trinitroglycerin and its metabolites in patients with chronic stable angina.
Topics: Aged; Aged, 80 and over; Angina Pectoris; Chronic Disease; Female; Humans; Male; Middle Aged; Nitrog | 2000 |
Double-blind manometric assessment of two topical glyceryl trinitrate formulations in patients with chronic anal fissures.
Topics: Administration, Topical; Adult; Anal Canal; Chronic Disease; Cross-Over Studies; Double-Blind Method | 2000 |
Effects of endothelin a receptor blockade on endothelial function in patients with chronic heart failure.
Topics: Blood Flow Velocity; Brachial Artery; Chronic Disease; Dose-Response Relationship, Drug; Endothelin | 2001 |
Testing the effectiveness of converting patients to long-acting antianginal medications: The Quality of Life in Angina Research Trial (QUART).
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Health Stat | 2001 |
Aspirin inhibits the acute venodilator response to furosemide in patients with chronic heart failure.
Topics: Aged; Aspirin; Chronic Disease; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind M | 2001 |
Acute effects of vitamin C on platelet responsiveness to nitric oxide donors and endothelial function in patients with chronic heart failure.
Topics: Adult; Aged; Analysis of Variance; Antioxidants; Ascorbic Acid; Chronic Disease; Cross-Over Studies; | 2001 |
Glyceryl trinitrate vs. lateral sphincterotomy for chronic anal fissure: prospective, randomized trial.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Anal Canal; Chronic Disease; Fe | 2001 |
Long-term results of topical nitroglycerin in the treatment of chronic anal fissures are disappointing.
Topics: Acute Disease; Administration, Topical; Adult; Aged; Chronic Disease; Female; Fissure in Ano; Follow | 2001 |
[Chronic idiopathic anal pain syndrome].
Topics: Adult; Anal Canal; Analgesics; Anus Diseases; Botulinum Toxins; Chronic Disease; Colostomy; Female; | 2002 |
Evaluation of intrinsic sympathomimetic activity of beta-adrenoceptor blocking drugs in the treatment of patients with angina pectoris.
Topics: Acute Disease; Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Chronic Disease; Clinical T | 1976 |
[Treatment of chronic coronary insufficiency with Irrigor].
Topics: Adult; Aged; Chronic Disease; Coronary Disease; Drug Evaluation; Female; Humans; Male; Middle Aged; | 1979 |
Transdermal nitroglycerin efficacy in patients with chronic stable angina pectoris as related to sympathetic and renin-angiotensin-aldosterone activity.
Topics: Administration, Cutaneous; Aged; Aldosterone; Angina Pectoris; Blood Pressure; Chronic Disease; Doub | 1992 |
Avoidance of tolerance and lack of rebound with intermittent dose titrated transdermal glyceryl trinitrate. The Transdermal Nitrate Investigators.
Topics: Administration, Cutaneous; Administration, Sublingual; Adult; Aged; Angina Pectoris; Blood Pressure; | 1991 |
[Differential use of peripheral vasodilators in the treatment of chronic circulatory failure in patients with mitral valve insufficiency].
Topics: Adult; Chronic Disease; Clinical Trials as Topic; Heart Failure; Hemodynamics; Humans; Hydralazine; | 1990 |
[Use of digoxin and nitrong in chronic cor pulmonale in patients with pulmonary tuberculosis].
Topics: Adult; Aged; Chronic Disease; Digoxin; Drug Therapy, Combination; Female; Hemodynamics; Humans; Male | 1990 |
Chronic effects of transdermal nitroglycerin in stable angina pectoris: a within-patient, placebo-controlled study.
Topics: Administration, Cutaneous; Angina Pectoris; Blood Pressure; Chronic Disease; Clinical Trials as Topi | 1989 |
Slow release nifedipine plus atenolol in chronic stable angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Atenolol; Chronic Disease; Delayed-Action Preparations; Double-Blind M | 1989 |
Clinical safety and efficacy of once-daily amlodipine for chronic stable angina pectoris.
Topics: Amlodipine; Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Drug Administration Schedule | 1989 |
The variable effects of angiotensin converting enzyme inhibition on myocardial ischaemia in chronic stable angina.
Topics: Aged; Angina Pectoris; Chronic Disease; Coronary Circulation; Coronary Disease; Double-Blind Method; | 1989 |
Quality of life on angina therapy: a randomised controlled trial of transdermal glyceryl trinitrate against placebo.
Topics: Administration, Cutaneous; Adult; Aged; Angina Pectoris; Chronic Disease; Clinical Trials as Topic; | 1988 |
Comparison of transdermal nitrate and isosorbide dinitrate in chronic stable angina.
Topics: Administration, Oral; Administration, Topical; Adult; Angina Pectoris; Blood Pressure; Chronic Disea | 1986 |
Effect of pharmacologic therapy on angina frequency, ST segment depression during ambulatory ECG monitoring, and treadmill performance in patients with chronic stable mild angina.
Topics: Adult; Ambulatory Care; Angina Pectoris; Chronic Disease; Electrocardiography; Exercise Test; Female | 1988 |
Haemodynamic effects of combined oral nifedipine and sublingual nitroglycerin in patients with chronic stable angina.
Topics: Administration, Oral; Administration, Sublingual; Aged; Angina Pectoris; Chronic Disease; Delayed-Ac | 1987 |
Antianginal effects of intravenous nitroglycerin over 24 hours.
Topics: Administration, Sublingual; Aged; Angina Pectoris; Chronic Disease; Clinical Trials as Topic; Double | 1988 |
Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris.
Topics: Aged; Angina Pectoris; Chronic Disease; Coenzymes; Double-Blind Method; Electrocardiography; Exercis | 1985 |
[Our experiences with Nitrolingual Retard in chronic coronary insufficiency].
Topics: Capsules; Chronic Disease; Clinical Trials as Topic; Coronary Disease; Delayed-Action Preparations; | 1970 |
[Carbochromen in therapy of acute and chronic coronary insufficiency].
Topics: Acute Disease; Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Blood Pressure; Chronic Disease; | 1970 |
155 other studies available for nitroglycerin and Chronic Disease
| Article | Year |
|---|---|
High Recurrence Rate After Nonsurgical Treatment of Chronic Anal Fissure: Can It Be Prevented?
Topics: Anal Canal; Botulinum Toxins, Type A; Chronic Disease; Fissure in Ano; Humans; Nitroglycerin; Recurr | 2022 |
Predicting Residual Angina After Chronic Total Occlusion Percutaneous Coronary Intervention: Insights from the OPEN-CTO Registry.
Topics: Angina Pectoris; Chronic Disease; Coronary Angiography; Coronary Occlusion; Disease Progression; Hum | 2022 |
Topical treatments for anal fissure.
Topics: Administration, Topical; Anal Canal; Chronic Disease; Fissure in Ano; Humans; Nitroglycerin; Treatme | 2023 |
On Practice Guidelines for the Management of Anal Fissures.
Topics: Anal Canal; Chronic Disease; Fissure in Ano; Humans; Nitroglycerin | 2023 |
P2X7R-mediated autophagic impairment contributes to central sensitization in a chronic migraine model with recurrent nitroglycerin stimulation in mice.
Topics: Animals; Autophagy; Central Nervous System Sensitization; Chronic Disease; Disease Models, Animal; M | 2021 |
Does the duration of symptoms of anal fissure impact its response to conservative treatment? A prospective cohort study.
Topics: Acute Disease; Adolescent; Adult; Aged; Chronic Disease; Conservative Treatment; Constipation; Femal | 2017 |
Characterization of a novel model of chronic migraine.
Topics: Animals; Chronic Disease; Disease Models, Animal; Female; Freund's Adjuvant; Hyperalgesia; Male; Mic | 2014 |
Endothelial dysfunction in patients with chronic venous disease: an evaluation based on the flow-mediated dilatation test.
Topics: Adult; Brachial Artery; Case-Control Studies; Chronic Disease; Endothelium, Vascular; Female; Humans | 2015 |
Prognostic impact of chronic nitrate therapy in patients with vasospastic angina: multicentre registry study of the Japanese coronary spasm association.
Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Coronary Vasospasm; Female; Humans | 2015 |
Combined approach in the treatment of chronic anal fissures.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Digestive Syst | 2015 |
Comparative Effectiveness of Ranolazine Versus Traditional Therapies in Chronic Stable Angina Pectoris and Concomitant Diabetes Mellitus and Impact on Health Care Resource Utilization and Cardiac Interventions.
Topics: Adrenergic beta-Antagonists; Aged; Angina, Stable; Calcium Channel Blockers; Cardiovascular Agents; | 2015 |
0.4% glyceryl trinitrate ointment: new drug. Not useful for anal fissures.
Topics: Adult; Chronic Disease; Clinical Trials as Topic; Fissure in Ano; France; Humans; Nitroglycerin; Oin | 2008 |
Conservative medication follow-up for over 20 years of a patient with ischemic heart disease after diagnosis of chronic total occlusion of the 3 main coronary arteries.
Topics: Acute Coronary Syndrome; Administration, Sublingual; Angina Pectoris; Antihypertensive Agents; Chron | 2008 |
Botulinum toxin for recurrent anal fissure following lateral internal sphincterotomy (Br J Surg 2008; 95: 774-778).
Topics: Botulinum Toxins, Type A; Chronic Disease; Fissure in Ano; Humans; Neuromuscular Agents; Nitroglycer | 2008 |
[The role of glyceryl trinitrate in the treatment of anal fissure].
Topics: Acute Disease; Adult; Anal Canal; Chronic Disease; Diagnosis, Differential; Female; Fissure in Ano; | 2008 |
Glyceryl trinitrate: the management of chronic anal fissure in patients who are unfit for surgery.
Topics: Chronic Disease; Fissure in Ano; Humans; Nitroglycerin; Vasodilator Agents | 2008 |
Dose-dependent benefit of nitroglycerin on microcirculation of patients with severe heart failure.
Topics: Aged; Analysis of Variance; Chronic Disease; Dose-Response Relationship, Drug; Drug Monitoring; Fema | 2009 |
Diltiazem (2%) versus glyceryl trinitrate cream (0.2%) in the management of chronic anal fissure.
Topics: Adolescent; Adult; Aged; Calcium Channel Blockers; Chronic Disease; Diltiazem; Female; Fissure in An | 2009 |
Conservative and surgical treatment of chronic anal fissure: prospective longer term results.
Topics: Administration, Topical; Adult; Botulinum Toxins; Chronic Disease; Cohort Studies; Dilatation; Femal | 2010 |
[Local treatment of a chronic anal fissure with diltiazem vs. nitroglycerin. A comparative study].
Topics: Adult; Aged; Chronic Disease; Diltiazem; Female; Humans; Male; Middle Aged; Nitroglycerin; Prospecti | 2010 |
Efficacy of management algorithm for reducing need for sphincterotomy in chronic anal fissures.
Topics: Algorithms; Botulinum Toxins, Type A; Chronic Disease; Female; Fissure in Ano; Humans; Male; Neuromu | 2012 |
[Spinal cord stimulation for refractory chronic angina pectoris: 100 patients treated in our 12-year experience].
Topics: Aged; Algorithms; Angina Pectoris; Chronic Disease; Electric Stimulation Therapy; Electrodes, Implan | 2011 |
Treatment of chronic anal fissure with topical nitroglycerin ointment 0.4%: a prospective clinical study.
Topics: Administration, Topical; Chronic Disease; Dose-Response Relationship, Drug; Fissure in Ano; Humans; | 2011 |
Clinical experience with ranolazine in a veteran population with chronic stable angina.
Topics: Acetanilides; Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angina, Stable; Calcium Channel | 2012 |
Transient impairment of vasomotion function after successful chronic total occlusion recanalization.
Topics: Chronic Disease; Coronary Angiography; Coronary Circulation; Coronary Stenosis; Coronary Vessels; Fe | 2012 |
Nitroglycerin ointment (Rectiv) for anal fissure.
Topics: Administration, Topical; Chronic Disease; Fissure in Ano; Humans; Nitroglycerin; Ointments; Pain; Va | 2012 |
Management of chronic Achilles tendinopathy.
Topics: Achilles Tendon; Administration, Cutaneous; Adrenal Cortex Hormones; Adult; Analgesics; Blood Transf | 2012 |
Influence of ALDH2 Glu504Lys polymorphism on nitroglycerin response in chronic heart failure and involvement of Calcitonin Gene Related Peptide (CGRP).
Topics: Adult; Aged; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Calcitonin Gene-Related | 2012 |
[Vascular remodeling indicators and their impact on prognosis in patients with chronic heart failure].
Topics: Aorta; Blood Flow Velocity; Carotid Intima-Media Thickness; Case-Control Studies; Chronic Disease; E | 2012 |
Effectiveness of a novel serotonin blocker, sarpogrelate, for patients with angina pectoris.
Topics: Aged; Angina Pectoris; Chronic Disease; Collateral Circulation; Coronary Angiography; Drug Therapy, | 2002 |
Randomized clinical trial assessing the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissure (Br J Surg 2002; 89: 413-17).
Topics: Chronic Disease; Diltiazem; Fissure in Ano; Humans; Nitroglycerin; Randomized Controlled Trials as T | 2002 |
Randomized clinical trial assessing the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissure (Br J Surg 2002; 89: 413-17).
Topics: Chronic Disease; Diltiazem; Fissure in Ano; Humans; Isosorbide Dinitrate; Nitric Oxide Donors; Nitro | 2002 |
Diltiazem heals glyceryl trinitrate-resistant chronic anal fissures: a prospective study.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Calcium Channel Blockers; Chronic Disease; | 2002 |
Randomized clinical trial assessing the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissure (Br J Surg 2002; 89: 413-17).
Topics: Chronic Disease; Diltiazem; Fissure in Ano; Humans; Nitroglycerin; Randomized Controlled Trials as T | 2002 |
[Prognostication of hemodynamic efficacy of surgical correction of chronic coronary insufficiency based on stress test with nitroglycerine].
Topics: Chronic Disease; Coronary Disease; Echocardiography, Stress; Hemodynamics; Humans; Male; Middle Aged | 2003 |
Placebo treatment for anal fissure.
Topics: Botulinum Toxins; Chronic Disease; Fissure in Ano; Humans; Nitroglycerin; Placebos | 2003 |
Effect of chronic stress and sleep deprivation on both flow-mediated dilation in the brachial artery and the intracellular magnesium level in humans.
Topics: Adult; Brachial Artery; Chronic Disease; Endothelium, Vascular; Humans; Magnesium; Magnesium Deficie | 2004 |
Nitroglycerin spray rapidly improves pain in a patient with chronic painful diabetic neuropathy.
Topics: Administration, Topical; Adult; Chronic Disease; Diabetic Neuropathies; Humans; Male; Nitric Oxide D | 2004 |
Hypothalamic stimulation in chronic cluster headache: a pilot study of efficacy and mode of action.
Topics: Adult; Chronic Disease; Cluster Headache; Deep Brain Stimulation; Drug Resistance; Female; Follow-Up | 2005 |
Predictors of benefit in angina patients one year after completing enhanced external counterpulsation: initial responders to treatment versus nonresponders.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angioplasty, Balloon, Coronary; Chronic Disease; Co | 2005 |
Long-term results of topical glyceryl trinitrate ointment in children with anal fissure.
Topics: Administration, Topical; Anal Canal; Child; Chronic Disease; Female; Fissure in Ano; Follow-Up Studi | 2005 |
Endothelial dysfunction occurs in peripheral circulation patients with acute and stable coronary artery disease.
Topics: Acetylcholine; Acute Disease; Aged; C-Reactive Protein; Case-Control Studies; Chronic Disease; Coron | 2005 |
Pharmacologic therapy of anal fissure: worth the wait?
Topics: Anal Canal; Chronic Disease; Fissure in Ano; Humans; Neuromuscular Agents; Nitroglycerin; Vasodilato | 2005 |
The immediate and long-term outcome of enhanced external counterpulsation in treatment of chronic stable refractory angina.
Topics: Aged; Angina Pectoris; Chronic Disease; Combined Modality Therapy; Counterpulsation; Drug Administra | 2006 |
Nonsurgical treatment of chronic anal fissure: nitroglycerin and dilatation versus nifedipine and botulinum toxin.
Topics: Administration, Topical; Adult; Anti-Dyskinesia Agents; Botulinum Toxins; Catheterization; Chronic D | 2006 |
0.4% nitroglycerin ointment in the treatment of chronic anal fissure pain: a viewpoint by Richard Nelson.
Topics: Administration, Topical; Chronic Disease; Fissure in Ano; Humans; Nitric Oxide Donors; Nitroglycerin | 2006 |
0.4% nitroglycerin ointment in the treatment of chronic anal fissure pain : a viewpoint by Jonathan N. Lund.
Topics: Administration, Topical; Chronic Disease; Fissure in Ano; Humans; Meta-Analysis as Topic; Nitric Oxi | 2006 |
0.4% nitroglycerin ointment in the treatment of chronic anal fissure pain : a viewpoint by Laurence R. Sands.
Topics: Administration, Topical; Chronic Disease; Fissure in Ano; Humans; Nitric Oxide Donors; Nitroglycerin | 2006 |
Determining myocardial viability in chronic ischemic left ventricular dysfunction: a prospective comparison of rest-redistribution thallium 201 single-photon emission computed tomography, nitroglycerin-dobutamine echocardiography, and intracoronary myocar
Topics: Aged; Cell Survival; Chronic Disease; Echocardiography; Echocardiography, Stress; Female; Heart; Hum | 2006 |
Chemical versus surgical sphincterotomy for chronic fissure in ano.
Topics: Adult; Anal Canal; Chronic Disease; Female; Fissure in Ano; Humans; Male; Nitroglycerin; Treatment O | 2007 |
Randomized clinical trial comparing botulinum toxin injections with 0.2 per cent nitroglycerin ointment for chronic anal fissure (Br J Surg 2007; 94: 162-167).
Topics: Administration, Topical; Botulinum Toxins, Type A; Chronic Disease; Fissure in Ano; Humans; Injectio | 2007 |
Variation in clinical, manometric and endosonographic findings in anterior chronic anal fissure: a prospective study.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Endosonography; Female; Fissure in Ano; Follow-Up S | 2008 |
Impaired nitroglycerin biotransformation in patients with chronic heart failure.
Topics: Adult; Biotransformation; Chronic Disease; Heart Failure; Humans; Male; Middle Aged; Nitroglycerin; | 2008 |
Topical therapy is first line treatment for chronic anal fissure because of the risk of incontinence with sphincterotomy.
Topics: Administration, Topical; Chronic Disease; Defecation; Digestive System Surgical Procedures; Fecal In | 2008 |
[Effectiveness of the combined use of adrenergic beta receptor blockaders and long-acting nitrates in chronic ischemic heart disease].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Chronic Disease; Coronary Disease; Delayed-Action Preparat | 1981 |
[Current problems of treating ischemic heart disease in the polyclinic].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Chronic Disease; Coronary Disease; Delayed-Action Prep | 1982 |
Dose-response relationship of the beta-adrenoceptor antagonist bisoprolol in patients with coronary heart disease and chronic obstructive bronchitis.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Airway Resistance; Bisoprolol; Blood Pressure; Bronchitis; | 1984 |
[Use of nifedipine derivatives in treating ischemic heart disease patients].
Topics: Angina Pectoris; Cardiac Complexes, Premature; Chronic Disease; Coronary Disease; Dose-Response Rela | 1984 |
[Effect of various drugs on peripheral hemodynamics in left-ventricular insufficiency in patients with chronic ischemic heart disease].
Topics: Adult; Aged; Chronic Disease; Coronary Disease; Female; Heart Failure; Heart Ventricles; Hemodynamic | 1983 |
Chronic heart failure in the elderly: vasodilator therapy.
Topics: Aged; Blood Pressure; Chronic Disease; Female; Follow-Up Studies; Heart Failure; Humans; Hydralazine | 1983 |
Hemodynamic and hormonal response to transdermal nitroglycerin in normal subjects and in patients with congestive heart failure.
Topics: Administration, Topical; Chronic Disease; Drug Evaluation; Gels; Heart Failure; Hemodynamics; Humans | 1983 |
[Role of biogenic amines in the etiology of pulmonary hypertension in chronic nonspecific lung diseases and the effect of sustac].
Topics: Adult; Aged; Antihypertensive Agents; Bronchitis; Catecholamines; Chronic Disease; Humans; Hypertens | 1983 |
[Effect of nitroglycerin on pulmonary gas exchange and ventilation-perfusion ratios in chronic ischemic heart disease].
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Chronic Disease; Coronary Disease; Drug Evaluation; Hu | 1984 |
[Functional blood circulatory changes in the mucosal and submucosal layers of the bronchi in primary and secondary bronchitis patients].
Topics: Adult; Aminophylline; Blood Flow Velocity; Bronchi; Bronchitis; Chronic Disease; Female; Humans; Mal | 1984 |
[Changes in cerebral hemodynamics in chronic vertebro-basilar insufficiency].
Topics: Aged; Cerebrovascular Circulation; Chronic Disease; Combined Modality Therapy; Female; Hemodynamics; | 1984 |
[Effect of temporary sequential atrioventricular electrocardiostimulation on hemodynamics].
Topics: Aged; Cardiac Output; Cardiac Pacing, Artificial; Chronic Disease; Coronary Disease; Female; Heart; | 1984 |
[Enhancement of the effect of captopril in the 1st 48 hours of treating refractory heart failure. A comparison with intravenous trinitrine].
Topics: Adult; Aged; Captopril; Chronic Disease; Drug Evaluation; Drug Therapy, Combination; Female; Heart F | 1984 |
[Ambulatory treatment of chronic heart failure with peripheral vasodilators].
Topics: Ambulatory Care; Chronic Disease; Drug Therapy, Combination; Heart Failure; Humans; Isosorbide Dinit | 1984 |
Hemodynamic effects of nitrates in chronic heart failure and myocardial infarction.
Topics: Chronic Disease; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Myocardial Infarction; N | 1980 |
[Microcirculation in chronic ischemic heart disease and the effects of nitroglycerin on microcirculation].
Topics: Adult; Aged; Chronic Disease; Coronary Disease; Female; Humans; Male; Microcirculation; Middle Aged; | 1980 |
[Modern aspects of nitro preparation use].
Topics: Adult; Aged; Angina Pectoris; Cardiovascular Agents; Chronic Disease; Coronary Disease; Delayed-Acti | 1980 |
The use of injectable nitroglycerin in the cardiac catheterization laboratory. Nitroglycerin in cardiac catheterization.
Topics: Acute Disease; Arterial Occlusive Diseases; Blood Pressure; Cardiac Catheterization; Chronic Disease | 1982 |
Vascular smooth muscle responses to endothelial autacoids in rats with chronic coarctation hypertension.
Topics: Acetylcholine; Animals; Aorta, Abdominal; Aorta, Thoracic; Aortic Coarctation; Autacoids; Chronic Di | 1993 |
[Individual approach to vasodilator treatment of pulmonary hypertension in chronic bronchitis].
Topics: Adult; Aminophylline; Bronchitis; Chronic Disease; Humans; Hydralazine; Hypertension, Pulmonary; Mid | 1994 |
Variable responses of highly stenotic coronary arteries and collateral circulation to intracoronary injection of nitroglycerin in patients with chronic effort angina.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Cardiac Pacing, Artificial; Chronic Disease; Collatera | 1994 |
Impaired endothelium-dependent vasodilatory responses in hindlimb blood flow in dogs with congestive heart failure.
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Chronic Disease; Dogs; Endothelium, Vascular; Heart F | 1994 |
Effects of spinal cord stimulation on myocardial ischaemia during daily life in patients with severe coronary artery disease. A prospective ambulatory electrocardiographic study.
Topics: Aged; Angina Pectoris; Chronic Disease; Electric Stimulation Therapy; Electrocardiography, Ambulator | 1994 |
Restoration of coronary blood flow in severely narrowed and chronically occluded coronary arteries before and after angioplasty: implications regarding restenosis.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Blood Flow Velocity; Blood Pressure; Cardiac Output; Ch | 1994 |
Myocardial contractile state in dogs with chronic mitral regurgitation: echocardiographic approach to the peak systolic pressure/end-systolic area relationship.
Topics: Animals; Chronic Disease; Dobutamine; Dogs; Echocardiography; Methoxamine; Mitral Valve Insufficienc | 1993 |
Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide, prostaglandins, gastrin and polyamines.
Topics: Animals; Arginine; Chronic Disease; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Efl | 1995 |
Topical glyceryl trinitrate in the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Aged; Anal Canal; Chronic Disease; Dose-Response Relationship, Drug; | 1996 |
Use of glyceryl trinitrate ointment in the treatment of anal fissure.
Topics: Administration, Topical; Adult; Chronic Disease; Female; Fissure in Ano; Humans; Male; Manometry; Ni | 1996 |
Chronic cluster headache: provocation with carbon dioxide breathing and nitroglycerin.
Topics: Administration, Inhalation; Adult; Aged; Carbon Dioxide; Chronic Disease; Cluster Headache; Female; | 1996 |
Glyceryl trinitrate ointment for chronic anal fissure.
Topics: Chronic Disease; Fissure in Ano; Headache; Humans; Nitroglycerin; Ointments | 1997 |
Topical treatment of chronic anal fissures.
Topics: Adult; Chronic Disease; Double-Blind Method; Female; Fissure in Ano; Humans; Male; Nitroglycerin; Oi | 1997 |
Changing patterns of treatment for chronic anal fissure.
Topics: Adolescent; Adult; Chronic Disease; Dilatation; Female; Fissure in Ano; Humans; Male; Middle Aged; N | 1998 |
Worsening of head-up tilt test response during chronic beta-blocker therapy in patients treated for neurally mediated syncope.
Topics: Adrenergic beta-Antagonists; Adult; Chronic Disease; Female; Follow-Up Studies; Heart Arrest; Humans | 1998 |
Follow-up of patients with chronic anal fissure treated with topical glyceryl trinitrate.
Topics: Administration, Cutaneous; Chronic Disease; Fissure in Ano; Follow-Up Studies; Humans; Nitroglycerin | 1998 |
Nitroglycerin ointment for anal fissures: effective treatment or just a headache?
Topics: Acute Disease; Chronic Disease; Female; Fissure in Ano; Humans; Male; Nitroglycerin; Ointments; Pros | 1999 |
Treatment of chronic anal fissure with topical glyceryl trinitrate.
Topics: Administration, Topical; Adolescent; Adult; Aged; Chronic Disease; Female; Fissure in Ano; Humans; M | 1999 |
A comparison of botulinum toxin and nitroglycerin ointment for chronic anal fissure.
Topics: Botulinum Toxins; Chronic Disease; Fissure in Ano; Humans; Nitroglycerin | 1999 |
A comparison of botulinum toxin and nitroglycerin ointment for chronic anal fissure.
Topics: Botulinum Toxins; Chronic Disease; Drug Therapy, Combination; Fissure in Ano; Humans; Nitroglycerin; | 1999 |
Knowledge and use of sublingual nitroglycerin and cardiac-related quality of life in patients with chronic stable angina.
Topics: Administration, Sublingual; Aged; Angina Pectoris; Chronic Disease; Female; Health Knowledge, Attitu | 2000 |
[The nitric oxide system in a chronic deficiency of mesostriatal dopamine: the action of nitroglycerin].
Topics: Animals; Chronic Disease; Dopamine; Male; Muscle, Smooth, Vascular; Neostriatum; Neurotoxins; Nitric | 2000 |
[Cardiac tomography with 99mTc-tetrofosmin after nitrate administration in patients with ischemic cardiopathy and left ventricular dysfunction].
Topics: Adult; Aged; Chronic Disease; Heart; Hemodynamics; Humans; Male; Middle Aged; Myocardial Ischemia; N | 2000 |
Short- and long-term effect of glyceryl trinitrate (GTN) ointment 0.2% and 2% on anal canal pressure in patients with chronic anal fissures.
Topics: Adult; Anal Canal; Chronic Disease; Female; Fissure in Ano; Humans; Male; Nitroglycerin; Ointments; | 2000 |
Calcitonin gene-related peptide levels during nitric oxide-induced headache in patients with chronic tension-type headache.
Topics: Adult; Calcitonin Gene-Related Peptide; Chronic Disease; Female; Headache; Humans; Male; Middle Aged | 2001 |
Treatment of anal fissure with glyceryl trinitrate in patients referred for surgical management.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Female; Fissure in Ano; General Surgery; Humans; Ma | 2001 |
Chronic idiopathic anal pain: analysis of ultrasonography, pathology, and treatment.
Topics: Adult; Anal Canal; Analgesics; Anti-Dyskinesia Agents; Anus Diseases; Botulinum Toxins; Chronic Dise | 2001 |
Reasons for failure of glyceryl trinitrate treatment of chronic fissure-in-ano: a multivariate analysis.
Topics: Administration, Topical; Adult; Chronic Disease; Female; Fissure in Ano; Humans; Male; Middle Aged; | 2001 |
Inhibitory effects of verapamil and nitroglycerin on contraction and cytosolic Ca2+ levels in cerebrovascular smooth muscle during chronic cerebral vasospasm.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Chronic Disease; Cytosol; Disease Models, Anima | 2001 |
Vasodilatory capacity and vascular structure in long-standing hypertension: a LIFE substudy. Losartan Intervention For Endpoint-Reduction in Hypertension.
Topics: Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Brachial Artery; Carotid Artery, Common | 2002 |
Fos and nitric oxide synthase in rat brain with chronic mesostriatal dopamine deficiency: effects of nitroglycerin and hypoxia.
Topics: Animals; Brain; Brain Stem; Chronic Disease; Dopamine; Hypoxia; Male; NADPH Dehydrogenase; Neostriat | 2002 |
[Current treatment of chronic ischemic heart disease].
Topics: Adrenergic beta-Antagonists; Bradycardia; Chronic Disease; Coronary Disease; Humans; Nitroglycerin; | 1977 |
Long-term outpatient vasodilator therapy of congestive heart failure. Consideration of agents at rest and during exercise.
Topics: Chronic Disease; Drug Therapy, Combination; Heart Failure; Heart Ventricles; Hemodynamics; Humans; H | 1978 |
[Effect of some drugs on liver hemodynamics].
Topics: Chronic Disease; Humans; Liver Circulation; Liver Diseases; Microcirculation; Nitroglycerin; Papaver | 1979 |
[Extracardiac effect of nitroglycerin in chronic ischemic heart disease according to the study of microcirculation].
Topics: Adult; Aged; Chronic Disease; Conjunctiva; Coronary Disease; Female; Humans; Male; Microcirculation; | 1979 |
[The use of intravenous nitroglycerin in chronic cardiac failure].
Topics: Chronic Disease; Female; Heart Failure; Heart Rate; Hemodynamics; Humans; Injections, Intravenous; M | 1979 |
The effect of nitroglycerin in gas exchange on chronic obstructive pulmonary disease.
Topics: Acid-Base Equilibrium; Anthropometry; Bicarbonates; Blood; Blood Pressure; Carbon Dioxide; Chronic D | 1975 |
Clinical assessment of left ventricular regional contraction patterns and ejection fraction by high-resolution gated scintigraphy.
Topics: Acute Disease; Cardiac Output; Chronic Disease; Cineangiography; Coronary Disease; Electrocardiograp | 1975 |
[New aspects of the treatment of left ventricular failure: Nitroglycerin (author's transl)].
Topics: Acute Disease; Administration, Oral; Aged; Arteries; Blood Pressure; Cardiac Catheterization; Cardia | 1975 |
Clinium used in the treatment of chronic ischaemic cardiac failures.
Topics: Administration, Oral; Ambulatory Care; Angina Pectoris; Chronic Disease; Coronary Disease; Drug Eval | 1975 |
Vasodilator therapy for chronic left ventricular failure.
Topics: Adult; Aged; Chronic Disease; Female; Heart Failure; Hemodynamics; Humans; Isosorbide Dinitrate; Mal | 1976 |
[Treatment of chronic ischemic heart disease in the light of data on pathophysiology of coronary circulation].
Topics: Animals; Chronic Disease; Coronary Circulation; Coronary Disease; Dogs; Drug Evaluation; Nitroglycer | 1975 |
Hemodynamic effects of nitroglycerin ointment in congestive heart failure.
Topics: Aged; Blood Pressure; Cardiac Output; Chronic Disease; Female; Heart Failure; Hemodynamics; Humans; | 1976 |
Combination vasodilator therapy for severe chronic congestive heart failure.
Topics: Chronic Disease; Drug Therapy, Combination; Heart Failure; Hemodynamics; Humans; Hydralazine; Isosor | 1976 |
[Value of rheoencephalography in the diagnosis of chronic fibrosing cerebral arachnoiditis and several questions concerning therapy].
Topics: Adolescent; Adult; Arachnoiditis; Cell- and Tissue-Based Therapy; Cerebrovascular Circulation; Chron | 1976 |
[The effects of oxygen and vasodilators on pulmonary hemodynamics and blood gases in chronic lung disease].
Topics: Aged; Alprostadil; Chronic Disease; Female; Humans; Hypertension, Pulmonary; Lung Diseases; Male; Mi | 1992 |
Role of prostaglandin H2-thromboxane A2 in responses of cerebral arterioles during chronic hypertension.
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Arterioles; Brain; Bridged Bicyclo Compounds, Heteroc | 1992 |
Impaired endothelium-mediated vasodilation in the peripheral vasculature of patients with congestive heart failure.
Topics: Acetylcholine; Adult; Aged; Blood Flow Velocity; Cardiomyopathy, Dilated; Chronic Disease; Endotheli | 1992 |
Endothelial function in chronic congestive heart failure.
Topics: Acetylcholine; Adult; Arginine; Blood Flow Velocity; Brachial Artery; Chronic Disease; Endothelium, | 1992 |
[A course of nitrong use in the combined treatment and hospital rehabilitation of patients with chronic cor pulmonale].
Topics: Adult; Bronchitis; Chronic Disease; Combined Modality Therapy; Drug Evaluation; Hemodynamics; Humans | 1992 |
Endothelial dysfunction of hindquarter resistance vessels in experimental heart failure.
Topics: Acetylcholine; Animals; Arginine; Blood Vessels; Cardiac Output, Low; Chronic Disease; Dose-Response | 1992 |
Endothelium-dependent responses of cerebral blood vessels during chronic hypertension.
Topics: Animals; Arterioles; Blood Pressure; Bradykinin; Calcimycin; Cerebrovascular Circulation; Cerebrovas | 1991 |
[The role of peripheral vasodilators in the treatment of congestive heart failure in chronic cor pulmonale].
Topics: Chronic Disease; Drug Therapy, Combination; Heart Failure; Hemodynamics; Humans; Molsidomine; Nitrog | 1991 |
[Effect of nitroglycerin preparations on indicators of central hemodynamics in patients with pulmonary tuberculosis complicated by chronic cor pulmonale].
Topics: Adult; Aged; Chronic Disease; Dose-Response Relationship, Drug; Female; Hemodynamics; Humans; Male; | 1990 |
Myocardial ischemia caused by distal coronary-artery constriction in stable angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Angiography; Chronic Disease; Collateral Circulation; Constriction, Pa | 1990 |
[Characteristics of the clinical manifestations of stenocardia in patients with ischemic heart disease, without myocardial infarct, in relation to the state of the coronary bed].
Topics: Angina Pectoris; Chronic Disease; Coronary Angiography; Coronary Disease; Coronary Vasospasm; Diatri | 1990 |
Impairment of endothelium-dependent dilatation of basilar artery during chronic hypertension.
Topics: Acetylcholine; Animals; Arginine; Basilar Artery; Bradykinin; Chronic Disease; Endothelium, Vascular | 1990 |
[Intravenous nitroglycerin infusion suppresses exercise-induced arrhythmia in patients with ischemic cardiopathy: indications for chronic treatment ].
Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Chronic Disease; Coronary Circulation; Coronary D | 1990 |
[The dynamic changes in the functional characteristics of the vascular endothelium and smooth muscle cells under conditions of long-term hypercholesterolemia].
Topics: Acetylcholine; Animals; Aorta; Calcimycin; Chronic Disease; Diet, Atherogenic; Endothelium, Vascular | 1990 |
[Effect of hemodynamic changes on cardiac rhythm disorders: experience with long-term intravenous administration of nitroglycerin in patients with chronic heart failure].
Topics: Adult; Aged; Cardiac Complexes, Premature; Cardiomyopathy, Dilated; Chronic Disease; Hemodynamics; H | 1989 |
Drug-induced chronic pigmented purpura.
Topics: Aged; Chlordiazepoxide; Chronic Disease; Female; Furosemide; Humans; Male; Middle Aged; Nitroglyceri | 1989 |
[Nitroglycerin test in the nitrong treatment of patients with ischemic heart disease and chronic obstructive bronchitis].
Topics: Bronchitis; Chronic Disease; Coronary Disease; Hemodynamics; Humans; Monitoring, Physiologic; Nitrat | 1989 |
[Effect of butadione on lipid metabolism in chronic ischemic heart disease patients].
Topics: Chronic Disease; Coronary Disease; Dipyridamole; Drug Evaluation; Drug Therapy, Combination; Humans; | 1986 |
[Regional ventricular function before and after sublingual administration of nitroglycerin in patients with recent myocardial infarction in the subacute and chronic stage].
Topics: Cardiac Output; Chronic Disease; Coronary Disease; Electrocardiography; Follow-Up Studies; Humans; M | 1986 |
[Effectiveness of 2 drug forms of nitroglycerin--transdermal (preparation Nitroderm-TTS) and gingival application (preparation Trinitrolong)--in ischemic heart disease patients].
Topics: Administration, Topical; Angina Pectoris; Chronic Disease; Coronary Disease; Delayed-Action Preparat | 1986 |
Hemodynamic and volumetric effects of venodilation with nitroglycerin in chronic mitral regurgitation.
Topics: Adult; Aged; Chronic Disease; Female; Hemodynamics; Humans; Male; Middle Aged; Mitral Valve Insuffic | 1987 |
Nitroglycerin in chronic stable angina pectoris.
Topics: Administration, Sublingual; Angina Pectoris; Chronic Disease; Hemodynamics; Humans; Nitroglycerin; P | 1987 |
[The role of central hemodynamic disorders in the development of chronic cor pulmonale in pulmonary tuberculosis].
Topics: Adult; Aged; Chronic Disease; Female; Hemodynamics; Humans; Iodine Radioisotopes; Male; Middle Aged; | 1988 |
[The advantageous effects of a prolonged intravenous load with a nitroglycerin solution on the lesser circulation in patients with chronic heart failure].
Topics: Chronic Disease; Drug Evaluation; Drug Tolerance; Female; Heart Failure; Hemodynamics; Humans; Infus | 1988 |
[Characteristics of the course of pulmonary hypertension in patients with chronic obstructive bronchitis (2)].
Topics: Adolescent; Adult; Aged; Bronchitis; Chronic Disease; Hemodynamics; Humans; Hypertension; Hypertensi | 1988 |
[Diagnosis of chronic occlusive diseases of the visceral branches of the abdominal aorta].
Topics: Abdomen; Arteriosclerosis; Chronic Disease; Hot Temperature; Humans; Ischemia; Mesenteric Arteries; | 1985 |
[Effect of nitroglycerin on various indicators of hemodynamics in patients with chronic obstructive bronchitis complicated by pulmonary hypertension].
Topics: Adult; Blood Pressure; Blood Volume; Bronchitis; Cardiac Output; Chronic Disease; Hemodynamics; Huma | 1985 |
[Comparative evaluation of the effectiveness of various peripheral vasodilators in the treatment of cardiac insufficiency].
Topics: Administration, Oral; Adolescent; Adult; Captopril; Chronic Disease; Female; Heart Failure; Hemodyna | 1985 |
[Current problems in the diagnosis, prevention and treatment of chronic cor pulmonale].
Topics: Calcium Channel Blockers; Chronic Disease; Hemodynamics; Humans; Nitroglycerin; Pulmonary Circulatio | 1985 |
Isosorbide-5-mononitrate--effective monotherapy in chronic stable angina.
Topics: Administration, Oral; Aged; Angina Pectoris; Chronic Disease; Coronary Disease; Female; Hemodynamics | 1985 |
The nature of treatment selection in coronary artery disease. Experience with medical and surgical treatment of a chronic disease.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Chronic Disease; Coronary Artery Bypass; Coronary Dise | 1974 |
[Combined administration of obzidan and sustak in the treatment of patients with chronic coronary insufficiency].
Topics: Adult; Aged; Chronic Disease; Drug Therapy, Combination; Female; Heart; Heart Failure; Humans; Male; | 1974 |
[Change in the phase structure of the cardiac cycle (according to ultrasonic Doppler cardiogram data) during the euphyllin and nitroglycerin tests on bronchial asthma and chronic pneumonia patients].
Topics: Aminophylline; Asthma; Chronic Disease; Echocardiography; Heart Rate; Humans; Nitroglycerin; Pneumon | 1974 |
[Experiences in the use of anginine for chronic occlusive disease of the lower extremity artery, with special reference to the evaluation of its effects through angiography].
Topics: Adult; Aged; Angiography; Arteries; Chronic Disease; Female; Humans; Leg; Male; Middle Aged; Nitrogl | 1968 |
A clinical comparison of cluster headache and migraine.
Topics: Adolescent; Adult; Aged; Carotid Arteries; Chronic Disease; Diagnosis, Differential; Ergotamine; Fem | 1970 |
[Therapy of coronary insufficiency with carbochromen].
Topics: Acute Disease; Adult; Aged; Angina Pectoris; Blood Circulation; Blood Pressure; Chronic Disease; Cor | 1970 |
Is history alone sufficient for the diagnosis of coronary artery disease?
Topics: Age Factors; Angina Pectoris; Chronic Disease; Coronary Disease; Electrocardiography; Emotions; Exer | 1966 |
[Use of repository nitroglycerin in the treatment of chronic coronary insufficiency].
Topics: Chronic Disease; Coronary Disease; Humans; Nitroglycerin | 1970 |