nitroglycerin has been researched along with Cerebral Hemorrhage in 16 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Cerebral Hemorrhage: Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pooled analyses of previous randomised studies have suggested that very early treatment with glyceryl trinitrate (also known as nitroglycerin) improves functional outcome in patients with acute ischaemic stroke or intracerebral haemorrhage, but this finding was not confirmed in a more recent trial (RIGHT-2)." | 5.51 | Prehospital transdermal glyceryl trinitrate in patients with presumed acute stroke (MR ASAP): an ambulance-based, multicentre, randomised, open-label, blinded endpoint, phase 3 trial. ( Berkhemer, OA; Boomars, R; Boomsma, JMF; Caminada, K; de Leeuw, FE; Dippel, DWJ; Emmer, BJ; Esteve Cuevas, LM; Fransen, PSS; Hofmeijer, J; Kerkhoff, H; Kwa, VIH; Lingsma, HF; Lok, T; Majoie, CBLM; Miedema, I; Nederkoorn, PJ; Nieboer, D; O Pruissen, DM; Raaijmakers, TWM; Reinink, H; Roos, YBWEM; Schipper, MH; Schonewille, WJ; Siegers, A; Uniken Venema, SM; van 't Net, A; van den Berg, SA; van der Lugt, A; van der Worp, HB; van Dijk, GW; van Eijkelenburg, RPJ; van Oostenbrugge, RJ; van Vliet, JA; Visser, MC; Zwetsloot, CP, 2022) |
| "Background and Purpose- Pilot trials suggest that glyceryl trinitrate (GTN; nitroglycerin) may improve outcome when administered early after stroke onset." | 5.30 | Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage: Data From the RIGHT-2 Trial. ( Anderson, CS; Appleton, JP; Bath, PM; Berge, E; Cala, L; Dixon, M; England, TJ; Godolphin, PJ; Hepburn, T; Krishnan, K; Mair, G; Montgomery, AA; Phillips, SJ; Potter, J; Price, CI; Randall, M; Robinson, TG; Roffe, C; Rothwell, PM; Sandset, EC; Sanossian, N; Saver, JL; Siriwardena, AN; Sprigg, N; Venables, G; Wardlaw, JM; Woodhouse, LJ, 2019) |
| " Safety outcomes were adverse events." | 2.82 | Benefits and safety of transdermal glyceryl trinitrate in acute stroke: A systematic review and meta-analysis of randomized trials. ( Chan, WL; Lee, WF; Lim, BL; Loo, KV; Man Goh, CJ; Ng, WM; Situ, W, 2022) |
| "In patients with intracerebral hemorrhage within 48 hours of onset, GTN lowered blood pressure was safe but did not improve functional outcome." | 2.82 | Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis. ( Adami, A; Bath, PM; Becker, JL; Berge, E; Cala, LA; Casado, AM; Caso, V; Chen, C; Christensen, H; Collins, R; Czlonkowska, A; de Silva, A; Dineen, RA; Gommans, J; Koumellis, P; Krishnan, K; Lees, KR; Ntaios, G; Ozturk, S; Phillips, SJ; Pocock, SJ; Scutt, P; Sprigg, N; Szatmari, S; Wardlaw, JM; Woodhouse, L, 2016) |
| "High blood pressure is associated with poor outcome after stroke." | 2.80 | Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. ( , 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 3 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Lim, BL | 1 |
| Lee, WF | 1 |
| Ng, WM | 1 |
| Situ, W | 1 |
| Loo, KV | 1 |
| Man Goh, CJ | 1 |
| Chan, WL | 1 |
| van den Berg, SA | 1 |
| Uniken Venema, SM | 1 |
| Reinink, H | 1 |
| Hofmeijer, J | 1 |
| Schonewille, WJ | 1 |
| Miedema, I | 1 |
| Fransen, PSS | 1 |
| O Pruissen, DM | 1 |
| Raaijmakers, TWM | 1 |
| van Dijk, GW | 1 |
| de Leeuw, FE | 1 |
| van Vliet, JA | 1 |
| Kwa, VIH | 1 |
| Kerkhoff, H | 1 |
| van 't Net, A | 1 |
| Boomars, R | 1 |
| Siegers, A | 1 |
| Lok, T | 1 |
| Caminada, K | 1 |
| Esteve Cuevas, LM | 1 |
| Visser, MC | 1 |
| Zwetsloot, CP | 1 |
| Boomsma, JMF | 1 |
| Schipper, MH | 1 |
| van Eijkelenburg, RPJ | 1 |
| Berkhemer, OA | 1 |
| Nieboer, D | 1 |
| Lingsma, HF | 1 |
| Emmer, BJ | 1 |
| van Oostenbrugge, RJ | 1 |
| van der Lugt, A | 1 |
| Roos, YBWEM | 1 |
| Majoie, CBLM | 1 |
| Dippel, DWJ | 1 |
| Nederkoorn, PJ | 1 |
| van der Worp, HB | 1 |
| Krishnan, K | 3 |
| Law, ZK | 1 |
| Woodhouse, LJ | 2 |
| Dineen, RA | 2 |
| Sprigg, N | 3 |
| Wardlaw, JM | 3 |
| Bath, PM | 3 |
| Appleton, JP | 1 |
| Anderson, CS | 1 |
| Berge, E | 2 |
| Cala, L | 1 |
| Dixon, M | 1 |
| England, TJ | 1 |
| Godolphin, PJ | 1 |
| Hepburn, T | 1 |
| Mair, G | 1 |
| Montgomery, AA | 1 |
| Phillips, SJ | 2 |
| Potter, J | 1 |
| Price, CI | 1 |
| Randall, M | 1 |
| Robinson, TG | 1 |
| Roffe, C | 1 |
| Rothwell, PM | 2 |
| Sandset, EC | 1 |
| Sanossian, N | 1 |
| Saver, JL | 1 |
| Siriwardena, AN | 1 |
| Venables, G | 1 |
| Hankey, GJ | 1 |
| Scutt, P | 1 |
| Woodhouse, L | 1 |
| Adami, A | 1 |
| Becker, JL | 1 |
| Cala, LA | 1 |
| Casado, AM | 1 |
| Caso, V | 1 |
| Chen, C | 1 |
| Christensen, H | 1 |
| Collins, R | 1 |
| Czlonkowska, A | 1 |
| Gommans, J | 1 |
| Koumellis, P | 1 |
| Lees, KR | 1 |
| Ntaios, G | 1 |
| Ozturk, S | 1 |
| Pocock, SJ | 1 |
| de Silva, A | 1 |
| Szatmari, S | 1 |
| ANNONI, G | 1 |
| FERRARIO, R | 1 |
| MAGGI, A | 1 |
| Scialla, SJ | 1 |
| Kuroda, K | 1 |
| Kuwata, N | 1 |
| Sato, N | 1 |
| Funayama, M | 1 |
| Yabuta, A | 1 |
| Taguchi, S | 1 |
| Suzuki, M | 1 |
| Takahashi, A | 1 |
| Ogawa, A | 1 |
| Kanji, S | 1 |
| Corman, C | 1 |
| Douen, AG | 1 |
| Matsuyama, T | 1 |
| Aoyama, N | 1 |
| Tsukamoto, M | 1 |
| Boggild, M | 1 |
| Hadjiev, D | 1 |
2 reviews available for nitroglycerin and Cerebral Hemorrhage
| Article | Year |
|---|---|
Benefits and safety of transdermal glyceryl trinitrate in acute stroke: A systematic review and meta-analysis of randomized trials.
Topics: Cerebral Hemorrhage; Humans; Ischemic Stroke; Nitroglycerin; Randomized Controlled Trials as Topic; | 2022 |
Impedance methods for investigation of cerebral circulation.
Topics: Adenosine Triphosphate; Animals; Brain Neoplasms; Carbon Dioxide; Carotid Artery Diseases; Cerebral | 1972 |
6 trials available for nitroglycerin and Cerebral Hemorrhage
| Article | Year |
|---|---|
Prehospital transdermal glyceryl trinitrate in patients with presumed acute stroke (MR ASAP): an ambulance-based, multicentre, randomised, open-label, blinded endpoint, phase 3 trial.
Topics: Adolescent; Adult; Ambulances; Brain Ischemia; Cerebral Hemorrhage; Humans; Ischemic Attack, Transie | 2022 |
Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage: Data From the RIGHT-2 Trial.
Topics: Acute Disease; Administration, Cutaneous; Aged; Aged, 80 and over; Blood Pressure; Cerebral Hemorrha | 2019 |
Baseline characteristics of the 4011 patients recruited into the ‘Efficacy of Nitric Oxide in Stroke’ (ENOS) trial.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; | 2014 |
Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Brain Ischemia; Cerebral Hemorrhage; Disease Manag | 2015 |
Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis.
Topics: Acute Disease; Aged; Aged, 80 and over; Cerebral Hemorrhage; Female; Humans; Male; Middle Aged; Nitr | 2016 |
Changes in cerebral blood flow accompanied with reduction of blood pressure treatment in patients with hypertensive intracerebral hemorrhages.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Cerebral Hemorrhage; Cerebrovascular Circulati | 1997 |
8 other studies available for nitroglycerin and Cerebral Hemorrhage
| Article | Year |
|---|---|
Measures of intracranial compartments in acute intracerebral haemorrhage: data from the Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke-2 Trial (RIGHT-2).
Topics: Atrophy; Cerebral Hemorrhage; Humans; Hypertension; Leukoaraiosis; Nitroglycerin; Stroke | 2023 |
Blood pressure in acute stroke: which questions remain?
Topics: Antihypertensive Agents; Brain Ischemia; Cerebral Hemorrhage; Female; Humans; Male; Nitroglycerin; S | 2015 |
ACP Journal Club: glyceryl trinitrate did not improve functional outcome in patients with acute stroke and high BP.
Topics: Antihypertensive Agents; Brain Ischemia; Cerebral Hemorrhage; Female; Humans; Male; Nitroglycerin; S | 2015 |
[USE OF TRINITROGLYCERIN BY VENOUS OR ARTERIAL ROUTE IN ARTERIOPATHIES EXCLUDING CORONARY CIRCULATION].
Topics: Arteriosclerosis; Cerebral Hemorrhage; Cerebrovascular Disorders; Coronary Circulation; Diabetic Ang | 1963 |
Case 27-1993: cerebral vasculitis.
Topics: Cerebral Hemorrhage; Humans; Intracranial Pressure; Nitroglycerin; Nitroprusside; Vasculitis | 1994 |
Blood pressure management in acute stroke: comparison of current guidelines with prescribing patterns.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Cerebral Hemorrhage; Female | 2002 |
[Intentional hypotension therapy induced by nitroglycerin and the changes in the intracranial pressure for acute hemorrhagic intracranial lesions].
Topics: Acute Disease; Aged; Aged, 80 and over; Blood Pressure; Cerebral Hemorrhage; Female; Humans; Infusio | 1992 |
Intracerebral haemorrhage after dermal nitrate application.
Topics: Administration, Cutaneous; Aged; Cerebral Hemorrhage; Female; Humans; Nitroglycerin | 1992 |