Page last updated: 2024-11-01

nitroglycerin and Cephalgia, Vascular

nitroglycerin has been researched along with Cephalgia, Vascular in 14 studies

Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.

Research Excerpts

ExcerptRelevanceReference
"To develop a reliable experimental model of vascular headache, we studied the dose-response relationship between headache and i."2.66Intravenous nitroglycerin as an experimental model of vascular headache. Basic characteristics. ( Iversen, HK; Olesen, J; Tfelt-Hansen, P, 1989)
"As the molecular mechanism of migraine pain remains to be determined, NTG, being pro-drug for NO, has been used to study the aetiology and pathophysiology of migraine."2.42The role of nitric oxide in vascular headache. ( Lohman, JJ; van der Kuy, PH, 2003)
"The molecular mechanisms of migraine pain remain to be determined."1.29The nitric oxide hypothesis of migraine and other vascular headaches. ( Lassen, LH; Olesen, IJ; Olesen, J; Thomsen, LL, 1995)
"Nitroglycerin (NG) induces in cluster headache patients and controls an increase in systemic diastolic blood pressure and/or heart rate and a decrease in blood flow velocity in the middle cerebral artery (VMCA)."1.28Cluster headache and "dynamite headache": blood flow velocities in the middle cerebral artery. ( Hannerz, J; Hellström, G; Klum, T; Wahlgren, NG, 1990)
"Attacks of cluster headache provoked by the administration of nitroglycerin (1 mg sublingually) or histamine (0."1.28Studies on nitroglycerin and histamine provoked cluster headache attacks. ( Bogucki, A, 1990)
"15 chronic cluster headache patients in whom pain was induced by nitroglycerin received acute intravenous treatment with a calcium entry blocker."1.27Calcium entry blocker: treatment in acute pain in cluster headache patients. ( Boiardi, A; Bussone, G; Gemma, M; Peccarisi, C; Porta, E, 1986)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19909 (64.29)18.7374
1990's4 (28.57)18.2507
2000's1 (7.14)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
van der Kuy, PH1
Lohman, JJ1
Krabbe, AA1
Henriksen, L1
Olesen, J3
Thomsen, LL1
Lassen, LH1
Olesen, IJ1
Heyck, H1
Hannerz, J1
Hellström, G1
Klum, T1
Wahlgren, NG1
Bogucki, A1
Dahl, A1
Russell, D1
Nyberg-Hansen, R1
Rootwelt, K1
Jelencsik, I1
Kovács, K1
Csanda, E1
Iversen, HK1
Tfelt-Hansen, P1
Boiardi, A1
Gemma, M1
Porta, E1
Peccarisi, C1
Bussone, G1
Drummond, PD1
Anthony, M1
Ekbom, K1
Gudina, ON1
Nager, F1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 2a Study of the Safety and Effectiveness of NXN-188 for the Acute Treatment of Migraine Attacks With Aura[NCT00877838]Phase 240 participants (Anticipated)Interventional2009-05-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for nitroglycerin and Cephalgia, Vascular

ArticleYear
The role of nitric oxide in vascular headache.
    Pharmacy world & science : PWS, 2003, Volume: 25, Issue:4

    Topics: Histamine; History, 19th Century; History, 20th Century; Humans; Migraine Disorders; Nitric Oxide; N

2003
[Clinical characteristics of cluster headache].
    Orvosi hetilap, 1989, May-28, Volume: 130, Issue:22

    Topics: Chronic Disease; Cluster Headache; Humans; Nitroglycerin; Pulse; Vascular Headaches

1989

Trials

1 trial available for nitroglycerin and Cephalgia, Vascular

ArticleYear
Intravenous nitroglycerin as an experimental model of vascular headache. Basic characteristics.
    Pain, 1989, Volume: 38, Issue:1

    Topics: Adult; Dose-Response Relationship, Drug; Female; Humans; Injections, Intravenous; Male; Nitroglyceri

1989

Other Studies

11 other studies available for nitroglycerin and Cephalgia, Vascular

ArticleYear
Tomographic determination of cerebral blood flow during attacks of cluster headache.
    Cephalalgia : an international journal of headache, 1984, Volume: 4, Issue:1

    Topics: Adult; Cerebrovascular Circulation; Cluster Headache; Ethanol; Humans; Male; Middle Aged; Nitroglyce

1984
The nitric oxide hypothesis of migraine and other vascular headaches.
    Cephalalgia : an international journal of headache, 1995, Volume: 15, Issue:2

    Topics: Cyclic GMP; Histamine; Humans; Migraine Disorders; Nitric Oxide; Nitroglycerin; Vascular Headaches

1995
[Cluster headache].
    Deutsche medizinische Wochenschrift (1946), 1975, Jun-06, Volume: 100, Issue:23

    Topics: Age Factors; Ethanol; Headache; Humans; Nitroglycerin; Rest; Seasons; Sex Factors; Syndrome; Time Fa

1975
Cluster headache and "dynamite headache": blood flow velocities in the middle cerebral artery.
    Cephalalgia : an international journal of headache, 1990, Volume: 10, Issue:1

    Topics: Adult; Aged; Blood Flow Velocity; Cerebral Arteries; Cluster Headache; Female; Humans; Male; Middle

1990
Studies on nitroglycerin and histamine provoked cluster headache attacks.
    Cephalalgia : an international journal of headache, 1990, Volume: 10, Issue:2

    Topics: Adult; Cluster Headache; Histamine; Humans; Male; Middle Aged; Nitroglycerin; Time Factors; Vascular

1990
Cluster headache: transcranial Doppler ultrasound and rCBF studies.
    Cephalalgia : an international journal of headache, 1990, Volume: 10, Issue:2

    Topics: Adult; Blood Flow Velocity; Cerebral Arteries; Cerebrovascular Circulation; Cluster Headache; Humans

1990
Calcium entry blocker: treatment in acute pain in cluster headache patients.
    Italian journal of neurological sciences, 1986, Volume: 7, Issue:5

    Topics: Blood Pressure; Cluster Headache; Humans; Indomethacin; Lithium; Nitroglycerin; Pain Measurement; Pu

1986
Extracranial vascular responses to sublingual nitroglycerin and oxygen inhalation in cluster headache patients.
    Headache, 1985, Volume: 25, Issue:2

    Topics: Adult; Cluster Headache; Humans; Middle Aged; Nitroglycerin; Orbit; Oxygen; Pulse; Regional Blood Fl

1985
Clinical aspects of cluster headache.
    Headache, 1974, Volume: 13, Issue:4

    Topics: Adolescent; Adult; Age Factors; Aged; Blood Pressure; Electrocardiography; Female; Headache; Heart R

1974
[Neuropathologic syndromes in patients with arterial hypotension].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1974, Volume: 74, Issue:12

    Topics: Adult; Ataxia; Blood Pressure; Electrocardiography; Electroencephalography; Eye Manifestations; Fema

1974
[Conservative therapy of angina pectoris].
    Schweizerische medizinische Wochenschrift, 1970, May-16, Volume: 100, Issue:20

    Topics: Acute Disease; Amyl Nitrite; Angina Pectoris; Anticoagulants; Coronary Disease; Digitalis Glycosides

1970