nitroglycerin has been researched along with Catheter-Associated Infections in 2 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chaftari, AM | 2 |
| Hachem, R | 2 |
| Szvalb, A | 1 |
| Taremi, M | 1 |
| Granwehr, B | 1 |
| Viola, GM | 1 |
| Amin, S | 1 |
| Assaf, A | 1 |
| Numan, Y | 1 |
| Shah, P | 1 |
| Gasitashvili, K | 1 |
| Natividad, E | 1 |
| Jiang, Y | 1 |
| Slack, R | 1 |
| Reitzel, R | 1 |
| Rosenblatt, J | 2 |
| Mouhayar, E | 1 |
| Raad, I | 1 |
| Vargas-Cruz, N | 1 |
| Reitzel, RA | 1 |
| Wilson Dib, R | 1 |
| Kontoyiannis, DP | 1 |
| Raad, II | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 1/2 Study to Evaluate the Safety and Effectiveness of Novel Non-Antibiotic, Non-Heparin Nitroglycerin Based Catheter Lock Solution Used for the Prevention of Intraluminal Central Venous Catheter (CVC) Infections in Cancer Patients[NCT02577718] | Phase 1/Phase 2 | 60 participants (Actual) | Interventional | 2015-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Catheter-Associated Infections will be measured by microbiological culture defined as either Catheter-Related Bloodstream Infection (CRBSI) as defined by the Infectious Diseases Society of America (IDSA), particularly in neutropenic patients, or Central Line-Associated Bloodstream Infection (CLABSI) as defined by the Centers for Disease Control and Prevention (CDC), particularly in non-neutropenic patients (NCT02577718)
Timeframe: 60 Days
| Intervention | infections per 1000 catheter days (Number) |
|---|---|
| NiCE Lock | 0 |
| Off NiCE Lock | 1.6 |
Drug-related hypotension is defined as a significant drop in measured blood pressure (BP) that exceeds the normal BP variability of a patient by 30%, that is associated with clinical signs and symptoms (dizziness and syncope) and is unexplained by factors other than the lock solution (such as other antihypertensive drugs, sepsis, bleeding). BP variability will be based on the standard deviation (SD) of a patient's blood pressure measured in the 3 days preceding participation in this trial and will be calculated at the time of trial entry. (NCT02577718)
Timeframe: From date of randomization until date of first Drug-Related Hypotension within 10 minutes of each flush, assessed up to 60 days
| Intervention | Participants (Count of Participants) |
|---|---|
| NiCE Lock | 0 |
2 other studies available for nitroglycerin and Catheter-Associated Infections
| Article | Year |
|---|---|
A Novel Nonantibiotic Nitroglycerin-Based Catheter Lock Solution for Prevention of Intraluminal Central Venous Catheter Infections in Cancer Patients.
Topics: Adult; Aged; Aged, 80 and over; Catheter-Related Infections; Catheterization, Central Venous; Centra | 2017 |
Nitroglycerin-Citrate-Ethanol Catheter Lock Solution Is Highly Effective for
Topics: Amphotericin B; Anidulafungin; Antifungal Agents; Biofilms; Candida; Caspofungin; Catheter-Related I | 2019 |