nitroglycerin has been researched along with Cancer of Prostate in 11 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the use of topical lidocaine gel and glyceryl trinitrate ointment (GTN) vs placebo, in reducing anal pain and discomfort as an adjunct to periprostatic anesthesia because of probe insertion, during the use of transrectal ultrasonography (TRUS) prostate-guided biopsy in young patients." | 3.77 | Comparison between lidocaine and glyceryl trinitrate ointment for perianal-intrarectal local anesthesia before transrectal ultrasonography-guided prostate biopsy: a placebo-controlled trial. ( Gekas, A; Konstantinidis, C; Samarinas, M; Skriapas, K; Xanthis, S, 2011) |
| "Using human DU145 prostate cancer cells, we assessed the effect of the NO mimetic glyceryl trinitrate (GTN) and the cGMP analogue 8-Bromo-cGMP on hypoxic accumulation of HIF-1α." | 1.56 | Inhibition of hypoxia-inducible factor 1α accumulation by glyceryl trinitrate and cyclic guanosine monophosphate. ( Barsoum, IB; Graham, CH; Kim, J; Loh, H; Paré, JF; Siemens, DR, 2020) |
| "Survival of human prostate and breast cancer cells was assessed by clonogenic assays following exposure to chemotherapeutic agents." | 1.34 | Chemosensitization of cancer in vitro and in vivo by nitric oxide signaling. ( Adams, MA; Bennett, BM; Frederiksen, LJ; Graham, CH; Macdonald-Goodfellow, SK; Maxwell, LR; Siemens, DR; Sullivan, R, 2007) |
| "Hypoxia is also associated with human prostate cancers, which are highly resistant to chemotherapy." | 1.32 | Hypoxia induced resistance to doxorubicin in prostate cancer cells is inhibited by low concentrations of glyceryl trinitrate. ( Adams, MA; Frederiksen, LJ; Graham, CH; Heaton, JP; Maxwell, LR; Siemens, DR, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, J | 1 |
| Barsoum, IB | 1 |
| Loh, H | 1 |
| Paré, JF | 1 |
| Siemens, DR | 5 |
| Graham, CH | 5 |
| Gilbert, SE | 1 |
| Tew, GA | 1 |
| Bourke, L | 1 |
| Winter, EM | 1 |
| Rosario, DJ | 1 |
| Hu, N | 1 |
| Sheikhi, AK | 1 |
| Chung, E | 1 |
| Frederiksen, LJ | 3 |
| Pross, H | 1 |
| Heaton, JP | 2 |
| Adams, MA | 3 |
| Kawakami, J | 1 |
| Skriapas, K | 1 |
| Konstantinidis, C | 1 |
| Samarinas, M | 1 |
| Xanthis, S | 1 |
| Gekas, A | 1 |
| Djavan, B | 1 |
| Maxwell, LR | 2 |
| Sullivan, R | 1 |
| Macdonald-Goodfellow, SK | 1 |
| Bennett, BM | 1 |
| McCabe, JE | 1 |
| Hanchanale, VS | 1 |
| Philip, J | 1 |
| Javle, PM | 1 |
| Brewster, S | 1 |
| Rochester, M | 1 |
| Kontturi, M | 1 |
| Sotaniemi, E | 1 |
| Ahlqvist, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Androgen Deprivation Therapy on Left Ventricular Function in Prostate Cancer Patients and Survivors[NCT03275181] | 60 participants (Anticipated) | Observational | 2017-08-01 | Recruiting | |||
| The Effects of Exercise Training on Tumor Vascularity and Response to Neoadjuvant Therapy in Operable Breast Cancer: A Phase I-II Study[NCT00405678] | Phase 1/Phase 2 | 23 participants (Actual) | Interventional | 2006-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for nitroglycerin and Cancer of Prostate
| Article | Year |
|---|---|
Phase II study of nitric oxide donor for men with increasing prostate-specific antigen level after surgery or radiotherapy for prostate cancer.
Topics: Aged; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Nitric Oxide Donors; Nitroglyce | 2009 |
A randomized controlled trial of topical glyceryl trinitrate before transrectal ultrasonography-guided biopsy of the prostate.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Biopsy, Needle; Humans; | 2007 |
9 other studies available for nitroglycerin and Cancer of Prostate
| Article | Year |
|---|---|
Inhibition of hypoxia-inducible factor 1α accumulation by glyceryl trinitrate and cyclic guanosine monophosphate.
Topics: Calpain; Cell Line, Tumor; Cyclic GMP; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Nitr | 2020 |
Assessment of endothelial dysfunction by flow-mediated dilatation in men on long-term androgen deprivation therapy for prostate cancer.
Topics: Aged; Androgen Antagonists; Blood Flow Velocity; Brachial Artery; Cardiovascular Diseases; Case-Cont | 2013 |
Hypoxia increases tumor cell shedding of MHC class I chain-related molecule: role of nitric oxide.
Topics: Adenocarcinoma; Animals; Cells, Cultured; Histocompatibility Antigens Class I; Humans; Hypoxia; Immu | 2008 |
Comparison between lidocaine and glyceryl trinitrate ointment for perianal-intrarectal local anesthesia before transrectal ultrasonography-guided prostate biopsy: a placebo-controlled trial.
Topics: Anesthesia, Local; Anesthetics, Local; Biopsy, Needle; Gels; Humans; Lidocaine; Male; Nitroglycerin; | 2011 |
Editorial comment.
Topics: Anesthetics, Local; Biopsy, Needle; Gels; Humans; Lidocaine; Male; Nitroglycerin; Prostatic Neoplasm | 2011 |
Hypoxia induced resistance to doxorubicin in prostate cancer cells is inhibited by low concentrations of glyceryl trinitrate.
Topics: Adenocarcinoma; Blotting, Western; Cell Cycle; Doxorubicin; Drug Resistance, Neoplasm; Flow Cytometr | 2003 |
Chemosensitization of cancer in vitro and in vivo by nitric oxide signaling.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cyclic GMP; Drug R | 2007 |
A randomized controlled trial of topical glyceryl trinitrate before transrectal ultrasonography-guided biopsy of the prostate.
Topics: Administration, Topical; Humans; Male; Nerve Block; Nitroglycerin; Prostatic Neoplasms; Randomized C | 2007 |
Liver damage and estrogen therapy of prostatic cancer. Case report.
Topics: Adenocarcinoma; Aged; Blood Glucose; Carbutamide; Diabetes Mellitus; Diethylstilbestrol; Digoxin; Dr | 1972 |