nitroglycerin has been researched along with Cancer of Lung in 17 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seventeen patients with operable lung adenocarcinoma and stable angina pectoris were selected to investigate the effects of nitroglycerin on immunoreactivity for hypoxia-inducible factor 1alpha (HIF-1alpha), vascular endothelial growth factor (VEGF), P-glycoprotein (P-gp), the production of which is regulated by HIF-1, and p53 proteins in their resected tumor by semiquantitative immunohistochemical analyses." | 9.12 | Nitroglycerin treatment may enhance chemosensitivity to docetaxel and carboplatin in patients with lung adenocarcinoma. ( Asada, M; Fuji, H; Inoue, D; Kanda, A; Kaneta, T; Kondo, T; Nakayama, K; Okinaga, S; Sasaki, H; Sasaki, T; Suzuki, S; Suzuki, T; Takai, Y; Watanabe, M; Yamanda, S; Yamaya, M; Yanagihara, K; Yasuda, H; Yoshida, M; Zayasu, K, 2006) |
| "Seventeen patients with operable lung adenocarcinoma and stable angina pectoris were selected to investigate the effects of nitroglycerin on immunoreactivity for hypoxia-inducible factor 1alpha (HIF-1alpha), vascular endothelial growth factor (VEGF), P-glycoprotein (P-gp), the production of which is regulated by HIF-1, and p53 proteins in their resected tumor by semiquantitative immunohistochemical analyses." | 5.12 | Nitroglycerin treatment may enhance chemosensitivity to docetaxel and carboplatin in patients with lung adenocarcinoma. ( Asada, M; Fuji, H; Inoue, D; Kanda, A; Kaneta, T; Kondo, T; Nakayama, K; Okinaga, S; Sasaki, H; Sasaki, T; Suzuki, S; Suzuki, T; Takai, Y; Watanabe, M; Yamanda, S; Yamaya, M; Yanagihara, K; Yasuda, H; Yoshida, M; Zayasu, K, 2006) |
| "Nitroglycerin (NTG) is a vasodilating drug, which increases tumor blood flow and consequently decreases hypoxia." | 2.84 | [18F]FDG PET/CT-based response assessment of stage IV non-small cell lung cancer treated with paclitaxel-carboplatin-bevacizumab with or without nitroglycerin patches. ( Boellaard, R; de Jong, EE; Dingemans, AC; Groen, HJ; Hoekstra, OS; Lambin, P; Leijenaar, RT; Smit, EF; Troost, EG; van der Noort, V; van Elmpt, W, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.76) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 8 (47.06) | 24.3611 |
| 2020's | 3 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Arrieta, O | 2 |
| Hernández-Pedro, N | 1 |
| Maldonado, F | 1 |
| Ramos-Ramírez, M | 1 |
| Yamamoto-Ramos, M | 1 |
| López-Macías, D | 1 |
| Lozano, F | 1 |
| Zatarain-Barrón, ZL | 1 |
| Turcott, JG | 1 |
| Barrios-Bernal, P | 1 |
| Orozco-Morales, M | 1 |
| Flores-Estrada, D | 1 |
| Cardona, AF | 1 |
| Rolfo, C | 1 |
| Cacho-Díaz, B | 1 |
| Xie, X | 1 |
| Chen, L | 1 |
| Liu, X | 1 |
| Wu, Z | 1 |
| Lv, D | 1 |
| Ma, Y | 1 |
| Luo, J | 1 |
| Zhang, S | 1 |
| de Jong, EEC | 1 |
| Sanders, KJC | 1 |
| Deist, TM | 1 |
| van Elmpt, W | 2 |
| Jochems, A | 1 |
| van Timmeren, JE | 1 |
| Leijenaar, RTH | 1 |
| Degens, JHRJ | 1 |
| Schols, AMWJ | 1 |
| Dingemans, AC | 2 |
| Lambin, P | 2 |
| Ko, JC | 1 |
| Chen, JC | 1 |
| Yen, TC | 1 |
| Chen, TY | 1 |
| Ma, PF | 1 |
| Lin, YC | 1 |
| Cheng, HH | 1 |
| Taso, YC | 1 |
| Lin, YW | 1 |
| Reinmuth, N | 1 |
| Meyer, A | 1 |
| Hartwigsen, D | 1 |
| Schaeper, C | 1 |
| Huebner, G | 1 |
| Skock-Lober, R | 1 |
| Bier, A | 1 |
| Gerecke, U | 1 |
| Held, CP | 1 |
| Reck, M | 1 |
| Blake, M | 1 |
| de la Mata-Moya, MD | 1 |
| Corona, F | 1 |
| Turcott, J | 1 |
| Orta, D | 1 |
| Alexander-Alatorre, J | 1 |
| Gallardo-Rincón, D | 1 |
| Dingemans, AM | 1 |
| Groen, HJ | 2 |
| Herder, GJ | 1 |
| Stigt, JA | 1 |
| Smit, EF | 2 |
| Bahce, I | 1 |
| Burgers, JA | 1 |
| van den Borne, BE | 1 |
| Biesma, B | 1 |
| Vincent, A | 1 |
| van der Noort, V | 2 |
| Aerts, JG | 1 |
| Davidson, A | 1 |
| Veillard, AS | 1 |
| Tognela, A | 1 |
| Chan, MM | 1 |
| Hughes, BG | 1 |
| Boyer, M | 1 |
| Briscoe, K | 1 |
| Begbie, S | 1 |
| Abdi, E | 1 |
| Crombie, C | 1 |
| Long, J | 1 |
| Boyce, A | 1 |
| Lewis, CR | 1 |
| Varma, S | 1 |
| Broad, A | 1 |
| Muljadi, N | 1 |
| Chinchen, S | 1 |
| Espinoza, D | 1 |
| Coskinas, X | 1 |
| Pavlakis, N | 1 |
| Millward, M | 1 |
| Stockler, MR | 1 |
| de Jong, EE | 1 |
| Leijenaar, RT | 1 |
| Hoekstra, OS | 1 |
| Boellaard, R | 1 |
| Troost, EG | 1 |
| Nagai, H | 1 |
| Yasuda, H | 3 |
| Hatachi, Y | 1 |
| Xue, D | 1 |
| Sasaki, T | 3 |
| Yamaya, M | 3 |
| Sakamori, Y | 1 |
| Togashi, Y | 1 |
| Masago, K | 1 |
| Ito, I | 1 |
| Kim, YH | 1 |
| Mio, T | 1 |
| Mishima, M | 1 |
| Han, JY | 1 |
| Nam, BH | 1 |
| Kim, HY | 1 |
| Yoon, SJ | 1 |
| Kim, HT | 1 |
| Lee, JS | 1 |
| MCCARROLL, HR | 1 |
| PRIEST, WS | 1 |
| COMPERE, EL | 1 |
| BEATTIE, EJ | 1 |
| BUCY, PC | 1 |
| Nakayama, K | 2 |
| Ebihara, S | 1 |
| Kanda, A | 2 |
| Asada, M | 2 |
| Inoue, D | 2 |
| Suzuki, T | 2 |
| Okazaki, T | 1 |
| Takahashi, H | 1 |
| Yoshida, M | 2 |
| Kaneta, T | 2 |
| Ishizawa, K | 1 |
| Yamanda, S | 2 |
| Tomita, N | 1 |
| Yamasaki, M | 1 |
| Kikuchi, A | 1 |
| Kubo, H | 1 |
| Sasaki, H | 2 |
| Mayor, S | 1 |
| Watanabe, M | 1 |
| Suzuki, S | 1 |
| Fuji, H | 1 |
| Okinaga, S | 1 |
| Zayasu, K | 1 |
| Kondo, T | 1 |
| Takai, Y | 1 |
| Yanagihara, K | 1 |
| Asao, Y | 1 |
| Takada, K | 1 |
| Takebe, S | 1 |
| Maeta, M | 1 |
| Mashima, Y | 1 |
| Wilhelm, R | 1 |
| Widow, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Nitroglycerin Plus Whole Intracranial Radiotherapy for Brain Metastases in Non-small Cell Lung Cancer Patients: a Phase II Open Randomized Clinical Trial[NCT04338867] | Phase 2 | 96 participants (Actual) | Interventional | 2020-03-01 | Completed | ||
| A Randomized Phase II Study of Paclitaxel-carboplatin-bevacizumab With or Without Nitroglycerin Patches in Patients With Stage IV Non-squamous-non-small Cell Lung Cancer: NVALT12[NCT01171170] | Phase 2 | 223 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 trials available for nitroglycerin and Cancer of Lung
| Article | Year |
|---|---|
Nitroglycerin Plus Whole Intracranial Radiation Therapy for Brain Metastases in Patients With Non-Small Cell Lung Cancer: A Randomized, Open-Label, Phase 2 Clinical Trial.
Topics: Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Cranial Irradiation; Humans; Lung Neoplasms; Nitrog | 2023 |
Can radiomics help to predict skeletal muscle response to chemotherapy in stage IV non-small cell lung cancer?
Topics: Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Bevacizumab; Carboplatin; Carcinom | 2019 |
Randomized, double-blind phase II study to compare nitroglycerin plus oral vinorelbine plus cisplatin with oral vinorelbine plus cisplatin alone in patients with stage IIIB/IV non-small cell lung cancer (NSCLC).
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Asian People; Carcin | 2014 |
Phase II study. Concurrent chemotherapy and radiotherapy with nitroglycerin in locally advanced non-small cell lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small | 2014 |
A randomized phase II study comparing paclitaxel-carboplatin-bevacizumab with or without nitroglycerin patches in patients with stage IV nonsquamous nonsmall-cell lung cancer: NVALT12 (NCT01171170)†.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Carbopl | 2015 |
A phase III randomized trial of adding topical nitroglycerin to first-line chemotherapy for advanced nonsmall-cell lung cancer: the Australasian lung cancer trials group NITRO trial.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Australia; Carcinoma | 2015 |
[18F]FDG PET/CT-based response assessment of stage IV non-small cell lung cancer treated with paclitaxel-carboplatin-bevacizumab with or without nitroglycerin patches.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Carboplatin; Carcinoma, No | 2017 |
A randomized phase II study of irinotecan plus cisplatin versus irinotecan plus capecitabine with or without isosorbide-5-mononitrate in advanced non-small-cell lung cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Carcinoma, | 2012 |
Randomized phase II trial comparing nitroglycerin plus vinorelbine and cisplatin with vinorelbine and cisplatin alone in previously untreated stage IIIB/IV non-small-cell lung cancer.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-S | 2006 |
Nitroglycerin treatment may enhance chemosensitivity to docetaxel and carboplatin in patients with lung adenocarcinoma.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; ATP Binding | 2006 |
7 other studies available for nitroglycerin and Cancer of Lung
| Article | Year |
|---|---|
Prophylactic Effect of Nitric Oxide Donors on Rat Models of EGFR Inhibitor‒Induced Cutaneous Toxicities.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Exanthema; Extracellular Signal-Regulated M | 2022 |
Nitroglycerin Enhances Cisplatin-Induced Cytotoxicity via AKT Inactivation and Thymidylate Synthase Downregulation in Human Lung Cancer Cells.
Topics: A549 Cells; Adenocarcinoma of Lung; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma | 2020 |
Nitric oxide (NO) enhances pemetrexed cytotoxicity via NO‑cGMP signaling in lung adenocarcinoma cells in vitro and in vivo.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antineoplastic Combined Chemotherapy Protocols; Apo | 2012 |
NECK, SHOULDER AND ARM PAIN.
Topics: Arm; Arm Injuries; Diagnosis, Differential; Heart Diseases; Humans; Joint Diseases; Lung Neoplasms; | 1964 |
Nitroglycerin shows promise in lung cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Clinical | 2006 |
[A case of coronary spasm during the operation for lung cancer].
Topics: Aged; Anesthesia, Epidural; Anesthesia, General; Coronary Vasospasm; Hemostasis, Surgical; Humans; I | 1992 |
[The effect of cross-sectional changes in lung circulation on human pulmonary artery pressure].
Topics: Blood Pressure; Blood Volume; Hematocrit; Humans; Hypertension; Lung Neoplasms; Nitroglycerin; Pneum | 1974 |