nitroglycerin has been researched along with Brain Ischemia in 24 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the safety and efficacy of NO donors, L-arginine, and NOS-I in people with acute stroke." | 8.95 | Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke. ( Appleton, JP; Bath, PM; Krishnan, K, 2017) |
| "The study was conducted to test the hypothesis that nitroglycerin (NTG) increases cerebral perfusion focally and globally in acute ischemic stroke patients, using serial perfusion-weighted imaging (PWI) magnetic resonance imaging measurements." | 8.02 | Nitroglycerin Is Not Associated with Improved Cerebral Perfusion in Acute Ischemic Stroke. ( Asdaghi, N; Beaulieu, C; Buck, B; Butcher, K; Emery, D; Gioia, L; Jeerakathil, T; Kate, M; Shuaib, A, 2021) |
| "Nitroglycerin (also known as glyceryl trinitrate (GTN)), a vasodilator best known for treatment of ischemic heart disease, has also been investigated for its potential therapeutic benefit in ischemic stroke." | 7.88 | Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke. ( Bix, GJ; Fraser, JF; Gorman, A; Learoyd, AE; Maniskas, ME; Roberts, JM; Trueman, R, 2018) |
| "Pooled analyses of previous randomised studies have suggested that very early treatment with glyceryl trinitrate (also known as nitroglycerin) improves functional outcome in patients with acute ischaemic stroke or intracerebral haemorrhage, but this finding was not confirmed in a more recent trial (RIGHT-2)." | 5.51 | Prehospital transdermal glyceryl trinitrate in patients with presumed acute stroke (MR ASAP): an ambulance-based, multicentre, randomised, open-label, blinded endpoint, phase 3 trial. ( Berkhemer, OA; Boomars, R; Boomsma, JMF; Caminada, K; de Leeuw, FE; Dippel, DWJ; Emmer, BJ; Esteve Cuevas, LM; Fransen, PSS; Hofmeijer, J; Kerkhoff, H; Kwa, VIH; Lingsma, HF; Lok, T; Majoie, CBLM; Miedema, I; Nederkoorn, PJ; Nieboer, D; O Pruissen, DM; Raaijmakers, TWM; Reinink, H; Roos, YBWEM; Schipper, MH; Schonewille, WJ; Siegers, A; Uniken Venema, SM; van 't Net, A; van den Berg, SA; van der Lugt, A; van der Worp, HB; van Dijk, GW; van Eijkelenburg, RPJ; van Oostenbrugge, RJ; van Vliet, JA; Visser, MC; Zwetsloot, CP, 2022) |
| "Transient focal ischemia caused by middle cerebral artery occlusion (MCAo) produces apoptotic cell death in the penumbra area." | 5.34 | Neuroprotective effect of nitroglycerin in a rodent model of ischemic stroke: evaluation of Bcl-2 expression. ( Amantea, D; Bagetta, G; Blandini, F; Corasaniti, MT; Greco, R; Nappi, G; Tassorelli, C, 2007) |
| "To assess the safety and efficacy of NO donors, L-arginine, and NOS-I in people with acute stroke." | 4.95 | Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke. ( Appleton, JP; Bath, PM; Krishnan, K, 2017) |
| "The study was conducted to test the hypothesis that nitroglycerin (NTG) increases cerebral perfusion focally and globally in acute ischemic stroke patients, using serial perfusion-weighted imaging (PWI) magnetic resonance imaging measurements." | 4.02 | Nitroglycerin Is Not Associated with Improved Cerebral Perfusion in Acute Ischemic Stroke. ( Asdaghi, N; Beaulieu, C; Buck, B; Butcher, K; Emery, D; Gioia, L; Jeerakathil, T; Kate, M; Shuaib, A, 2021) |
| "Nitroglycerin (also known as glyceryl trinitrate (GTN)), a vasodilator best known for treatment of ischemic heart disease, has also been investigated for its potential therapeutic benefit in ischemic stroke." | 3.88 | Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke. ( Bix, GJ; Fraser, JF; Gorman, A; Learoyd, AE; Maniskas, ME; Roberts, JM; Trueman, R, 2018) |
| "High blood pressure is associated with poor outcome after stroke." | 2.80 | Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. ( , 2015) |
| "High blood pressure (BP) in acute stroke has adverse outcomes." | 1.62 | Benefits and safety of transdermal glyceryl trinitrate in acute stroke: a systematic review and meta-analysis of randomised trials (protocol). ( Chan, WL; Lee, WF; Lim, BL; Ng, WM; Tay, WL, 2021) |
| "Transient focal ischemia caused by middle cerebral artery occlusion (MCAo) produces apoptotic cell death in the penumbra area." | 1.34 | Neuroprotective effect of nitroglycerin in a rodent model of ischemic stroke: evaluation of Bcl-2 expression. ( Amantea, D; Bagetta, G; Blandini, F; Corasaniti, MT; Greco, R; Nappi, G; Tassorelli, C, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (29.17) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 7 (29.17) | 24.3611 |
| 2020's | 6 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Reynolds, JN | 1 |
| Bennett, BM | 1 |
| Boegman, RJ | 1 |
| Jhamandas, K | 1 |
| Ratz, JD | 1 |
| Zavorin, SI | 1 |
| Scutaru, D | 1 |
| Dumitrascu, A | 1 |
| Thatcher, GR | 1 |
| Tunnage, B | 1 |
| Woodhouse, LJ | 4 |
| Dixon, M | 4 |
| Anderson, C | 1 |
| Ankolekar, S | 1 |
| Appleton, J | 1 |
| Cala, L | 1 |
| England, T | 1 |
| Krishnan, K | 2 |
| Havard, D | 4 |
| Mair, G | 1 |
| Muir, K | 1 |
| Phillips, S | 1 |
| Potter, J | 1 |
| Price, C | 1 |
| Randall, M | 1 |
| Robinson, TG | 1 |
| Roffe, C | 1 |
| Sandset, E | 1 |
| Siriwardena, N | 1 |
| Scutt, P | 4 |
| Wardlaw, JM | 1 |
| Sprigg, N | 1 |
| Bath, PM | 5 |
| van den Berg, SA | 1 |
| Uniken Venema, SM | 1 |
| Reinink, H | 1 |
| Hofmeijer, J | 1 |
| Schonewille, WJ | 1 |
| Miedema, I | 1 |
| Fransen, PSS | 1 |
| O Pruissen, DM | 1 |
| Raaijmakers, TWM | 1 |
| van Dijk, GW | 1 |
| de Leeuw, FE | 1 |
| van Vliet, JA | 1 |
| Kwa, VIH | 1 |
| Kerkhoff, H | 1 |
| van 't Net, A | 1 |
| Boomars, R | 1 |
| Siegers, A | 1 |
| Lok, T | 1 |
| Caminada, K | 1 |
| Esteve Cuevas, LM | 1 |
| Visser, MC | 1 |
| Zwetsloot, CP | 1 |
| Boomsma, JMF | 1 |
| Schipper, MH | 1 |
| van Eijkelenburg, RPJ | 1 |
| Berkhemer, OA | 1 |
| Nieboer, D | 1 |
| Lingsma, HF | 1 |
| Emmer, BJ | 1 |
| van Oostenbrugge, RJ | 1 |
| van der Lugt, A | 1 |
| Roos, YBWEM | 1 |
| Majoie, CBLM | 1 |
| Dippel, DWJ | 1 |
| Nederkoorn, PJ | 1 |
| van der Worp, HB | 1 |
| Gao, J | 1 |
| Cheng, Z | 1 |
| Jiang, S | 1 |
| Wills, M | 1 |
| Wehbe, A | 1 |
| Rajah, GB | 1 |
| Geng, X | 1 |
| Ding, Y | 1 |
| Appleton, JP | 4 |
| Haywood, LJ | 3 |
| Williams, J | 3 |
| Siriwardena, AN | 3 |
| Kate, M | 1 |
| Gioia, L | 1 |
| Asdaghi, N | 1 |
| Jeerakathil, T | 1 |
| Shuaib, A | 1 |
| Buck, B | 1 |
| Emery, D | 1 |
| Beaulieu, C | 1 |
| Butcher, K | 1 |
| Lim, BL | 1 |
| Lee, WF | 1 |
| Ng, WM | 1 |
| Tay, WL | 1 |
| Chan, WL | 1 |
| Rothwell, PM | 1 |
| Hankey, GJ | 1 |
| Maniskas, ME | 1 |
| Roberts, JM | 1 |
| Trueman, R | 1 |
| Learoyd, AE | 1 |
| Gorman, A | 1 |
| Fraser, JF | 1 |
| Bix, GJ | 1 |
| El-Zammar, ZM | 1 |
| Latorre, JG | 1 |
| Wang, D | 1 |
| Satyan, S | 1 |
| Elnour, E | 1 |
| Kamel, A | 1 |
| Devasenapathy, A | 1 |
| Lodi, YM | 1 |
| RONNOV-JESSEN, V | 2 |
| DATLOW, DW | 1 |
| MASSUMI, RA | 1 |
| Greco, R | 1 |
| Amantea, D | 1 |
| Blandini, F | 1 |
| Nappi, G | 1 |
| Bagetta, G | 1 |
| Corasaniti, MT | 1 |
| Tassorelli, C | 1 |
| Benhamou, AC | 1 |
| Daloz, M | 1 |
| Kieffer, E | 1 |
| Tricot, JF | 1 |
| Marsac, A | 1 |
| Ducardonnet, P | 1 |
| Natali, J | 1 |
| Grosgogeat, Y | 1 |
| Viars, P | 1 |
| Shenkman, Z | 1 |
| Elami, A | 1 |
| Weiss, YG | 1 |
| Glantz, L | 1 |
| Milgalter, E | 1 |
| Drenger, B | 1 |
| Burrows, FA | 1 |
| Shir, Y | 1 |
| Tanaka, Y | 1 |
| Masuzawa, T | 1 |
| Saito, M | 1 |
| Yamada, T | 1 |
| Ebihara, A | 1 |
| Iwasa, H | 1 |
| Mori, S | 1 |
| Pryszmont, M | 1 |
| Archie, JP | 1 |
| Langnickel, R | 1 |
| Bluth, R | 1 |
1 review available for nitroglycerin and Brain Ischemia
| Article | Year |
|---|---|
Nitric oxide donors (nitrates), L-arginine, or nitric oxide synthase inhibitors for acute stroke.
Topics: Acute Disease; Arginine; Brain Ischemia; Enzyme Inhibitors; Headache; Humans; Nitric Oxide Donors; N | 2017 |
6 trials available for nitroglycerin and Brain Ischemia
17 other studies available for nitroglycerin and Brain Ischemia
| Article | Year |
|---|---|
Neuroprotection against ischemic brain injury conferred by a novel nitrate ester.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Cyclic GMP; Dose-Response Relationship, Drug; Guanyl | 2002 |
Nitroglycerin Is Not Associated with Improved Cerebral Perfusion in Acute Ischemic Stroke.
Topics: Brain Ischemia; Cerebrovascular Circulation; Humans; Ischemic Stroke; Nitroglycerin; Perfusion; Stro | 2021 |
Benefits and safety of transdermal glyceryl trinitrate in acute stroke: a systematic review and meta-analysis of randomised trials (protocol).
Topics: Activities of Daily Living; Adult; Aged; Brain Ischemia; Humans; Meta-Analysis as Topic; Nitroglycer | 2021 |
Blood pressure in acute stroke: which questions remain?
Topics: Antihypertensive Agents; Brain Ischemia; Cerebral Hemorrhage; Female; Humans; Male; Nitroglycerin; S | 2015 |
ACP Journal Club: glyceryl trinitrate did not improve functional outcome in patients with acute stroke and high BP.
Topics: Antihypertensive Agents; Brain Ischemia; Cerebral Hemorrhage; Female; Humans; Male; Nitroglycerin; S | 2015 |
Intra-arterial nitroglycerin as directed acute treatment in experimental ischemic stroke.
Topics: Animals; Brain Ischemia; Infusions, Intra-Arterial; Laser-Doppler Flowmetry; Male; Mice; Mice, Inbre | 2018 |
Intra-arterial vasodilator use during endovascular therapy for acute ischemic stroke might improve reperfusion rate.
Topics: Acute Disease; Adult; Aged; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; C | 2012 |
[Cerebral complications caused by nitroglycerin treatment of angina pectoris].
Topics: Angina Pectoris; Brain Ischemia; Cerebral Infarction; Humans; Ischemic Attack, Transient; Nitroglyce | 1963 |
CEREBRAL COMPLICATIONS IN NITROGLYCERINE TREATMENT OF ANGINA PECTORIS.
Topics: Angina Pectoris; Brain Ischemia; Cerebral Infarction; Humans; Hypotension; Hypotension, Orthostatic; | 1963 |
THE POTENTIAL CEREBRAL AND CARDIOVASCULAR DANGERS OF NITROGLYCERIN.
Topics: Brain Ischemia; Cerebral Infarction; Drug Therapy; Geriatrics; Hypotension; Hypotension, Orthostatic | 1965 |
Neuroprotective effect of nitroglycerin in a rodent model of ischemic stroke: evaluation of Bcl-2 expression.
Topics: Animals; Blotting, Western; Brain Ischemia; Cerebral Cortex; Functional Laterality; Gene Expression; | 2007 |
[Myocardial ischemia and carotid surgery. Holter study of 21 severe coronary patients. Preventive effect of intravenous trinitrin].
Topics: Aged; Arteriosclerosis; Brain Ischemia; Carotid Artery Diseases; Coronary Circulation; Coronary Dise | 1982 |
Cerebral protection using retrograde cerebral perfusion during hypothermic circulatory arrest.
Topics: Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Brain Ischemia; Electrocardiography; Electr | 1997 |
Combined administration of Fasudil hydrochloride and nitroglycerin for treatment of cerebral vasospasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Brain Ischemia; Drug Combinations; Female; Huma | 2001 |
[Evaluation of rheoencephalographic studies with the use of the nitroglycerin test in ischemic cerebral stroke].
Topics: Adult; Aged; Brain; Brain Ischemia; Cerebrovascular Circulation; Cerebrovascular Disorders; Evaluati | 1979 |
The relationship of early hypertension following carotid endarterectomy to intraoperative cerebral ischemia.
Topics: Aged; Arterial Occlusive Diseases; Blood Vessel Prosthesis; Brain Ischemia; Carotid Artery Diseases; | 1988 |
[Pharmacologic properties and indications of modern vasodilator agents. 2: Indications and side effects of vasodilator agents].
Topics: Arterial Occlusive Diseases; Brain Ischemia; Cardiovascular Diseases; Coronary Disease; Drug Therapy | 1985 |