Page last updated: 2024-11-01

nitroglycerin and Bradycardia

nitroglycerin has been researched along with Bradycardia in 37 studies

Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.

Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.

Research Excerpts

ExcerptRelevanceReference
"Nitroglycerin (NTG) administration occasionally leads to syncope due to severe hypotension and bradycardia."7.71Nitroglycerin induced syncope occurs in subjects with delayed phase shift of baroreflex action. ( Ceska, R; Hradec, J; Malik, J; Malik, M; Melenovsky, V; Simek, J; Wichterle, D, 2002)
"Nitroglycerin (NTG) may cause paradoxical bradycardia and occasional life-threatening hypotension."7.68Hypotensive and bradycardiac responses to reflex sympathetic inhibition produced by nitroglycerin in rats with sinoaortic deafferentation. ( Long, JP; Ma, S, 1993)
"A case of severe bradycardia with junctional escape immediately following sublingual nitroglycerin is described."7.68Symptomatic bradycardia following the administration of sublingual nitroglycerin. ( Buckley, R; Roberts, R, 1993)
"Severe bradycardia associated with profound systemic arterial hypotension was observed in 3 patients following sublingual nitroglycerin administration."7.66Syndrome of severe bradycardia and hypotension following sublingual nitroglycerin administration. ( Nemerovski, M; Shah, PK, 1981)
"Seven episodes of simultaneous severe systemic arterial hypotension and absolute or relative bradycardia were observed in five patients receiving either sublingual nitroglycerin (two patients) or intravenous nitroglycerin (three patients) within the first 24 hours of onset of symptoms of acute myocardial infarction."7.65Nitroglycerin-induced severe hypotension and bradycardia in patients with acute myocardial infarction. ( Come, PC; Pitt, B, 1976)
"Rotational atherectomy (RA) may cause bradyarrhythmias and transitory atrioventricular block when performed in the right coronary artery (RCA) or a dominant circumflex (CX) coronary artery."7.30A mix of aminophylline and heparin plus nitroglycerin can reduce bradycardia during rotational atherectomy on the right coronary artery and dominant circumflex artery. ( Acar, E; Donmez, I; Güneş, Y; Izci, S; Izgi, IA; Kayabası, O; Kaygusuz, T; Kirma, C; Ozcan, E; Ozgul, N, 2023)
" Administration of nitroglycerin at 200 μg to relax uterine smooth muscles and the application of fundal pressure led to severe bradycardia and loss of consciousness, followed by cardiac arrest."3.85Neurally Mediated Syncope During Cesarean Delivery: A Case Report. ( Kusumoto, G; Nakamori, E; Sato, S; Shigematsu, K; Yamaura, K, 2017)
"Nitroglycerin (NTG) administration occasionally leads to syncope due to severe hypotension and bradycardia."3.71Nitroglycerin induced syncope occurs in subjects with delayed phase shift of baroreflex action. ( Ceska, R; Hradec, J; Malik, J; Malik, M; Melenovsky, V; Simek, J; Wichterle, D, 2002)
"Three hundred prehospital patients who were given nitroglycerin by advanced life support personnel for presumed myocardial ischemia or congestive heart failure; excluded were those without repeat vital signs or ECG monitoring and those given additional medications."3.69Safety of prehospital nitroglycerin. ( Holliman, CJ; Meador, S; Roth, GS; Swope, G; Wuerz, R, 1994)
"Nitroglycerin (NTG) may cause paradoxical bradycardia and occasional life-threatening hypotension."3.68Hypotensive and bradycardiac responses to reflex sympathetic inhibition produced by nitroglycerin in rats with sinoaortic deafferentation. ( Long, JP; Ma, S, 1993)
"Nitroglycerin dosage was not advanced appropriately in 78% of episodes despite evidence of bradycardia, hypertension and peripheral vasoconstriction."3.68Evaluation and revision of a vasopressin/nitroglycerin protocol for use in variceal bleeding. ( Burns, SM; Luer, J; Martin, M; Merrill, P; Stone, DD, 1993)
"A case of severe bradycardia with junctional escape immediately following sublingual nitroglycerin is described."3.68Symptomatic bradycardia following the administration of sublingual nitroglycerin. ( Buckley, R; Roberts, R, 1993)
"Within a half-year period, we encountered six cases of patients harmed by the adverse effects of self-administered nitroglycerin--syncope, delayed definitive medical care, and the worsening of nonischemic symptoms."3.68Defining the proper role for self-administered sublingual nitroglycerin. A survey of physicians and patients. ( Bassan, M, 1991)
"Severe bradycardia associated with profound systemic arterial hypotension was observed in 3 patients following sublingual nitroglycerin administration."3.66Syndrome of severe bradycardia and hypotension following sublingual nitroglycerin administration. ( Nemerovski, M; Shah, PK, 1981)
"Seven episodes of simultaneous severe systemic arterial hypotension and absolute or relative bradycardia were observed in five patients receiving either sublingual nitroglycerin (two patients) or intravenous nitroglycerin (three patients) within the first 24 hours of onset of symptoms of acute myocardial infarction."3.65Nitroglycerin-induced severe hypotension and bradycardia in patients with acute myocardial infarction. ( Come, PC; Pitt, B, 1976)
"Rotational atherectomy (RA) may cause bradyarrhythmias and transitory atrioventricular block when performed in the right coronary artery (RCA) or a dominant circumflex (CX) coronary artery."3.30A mix of aminophylline and heparin plus nitroglycerin can reduce bradycardia during rotational atherectomy on the right coronary artery and dominant circumflex artery. ( Acar, E; Donmez, I; Güneş, Y; Izci, S; Izgi, IA; Kayabası, O; Kaygusuz, T; Kirma, C; Ozcan, E; Ozgul, N, 2023)
"After the procedure both symptoms and orthostatic hypotension disappeared."1.35Persistent atrial fibrillation associated with syncope due to orthostatic hypotension: a case report. ( Baratella, MC; D'este, D; Reato, S, 2009)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199018 (48.65)18.7374
1990's11 (29.73)18.2507
2000's2 (5.41)29.6817
2010's4 (10.81)24.3611
2020's2 (5.41)2.80

Authors

AuthorsStudies
Acar, E1
Izci, S1
Donmez, I1
Ozgul, N1
Ozcan, E1
Kaygusuz, T1
Kayabası, O1
Güneş, Y1
Izgi, IA1
Kirma, C1
Takahashi, N1
Gall, E1
Fan, D1
Majid, M1
Amsterdam, EA1
Shah, SP1
Waxman, S1
Queiroz, TM1
Mendes-Júnior, LG1
Guimarães, DD1
França-Silva, MS1
Nalivaiko, E1
Braga, VA1
Wong, LY1
Wong, A1
Robertson, T1
Burns, K1
Roberts, M1
Isbister, GK1
Sato, S1
Nakamori, E1
Kusumoto, G1
Shigematsu, K1
Yamaura, K1
Reato, S1
Baratella, MC1
D'este, D1
Kupper, W1
Hamm, CW1
Bleifeld, W1
Capucci, A1
Bassein, L1
Bracchetti, D1
Carini, G1
Maresta, A1
Magnani, B1
von Arnim, T1
Autenrieth, G1
Bolte, HD1
Ong, EA1
Bass, S1
Meretoja, OA1
Khan, AH1
Carleton, RA1
Nemerovski, M1
Shah, PK1
Shapiro, W1
Park, J1
DiBianco, R1
Singh, SN1
Katz, RJ1
Fletcher, R1
Cheng, TO1
Ma, S1
Long, JP1
Wuerz, R1
Swope, G1
Meador, S1
Holliman, CJ1
Roth, GS1
Burns, SM1
Martin, M1
Merrill, P1
Luer, J1
Stone, DD1
Buckley, R1
Roberts, R1
Natale, A1
Sra, J1
Akhtar, M1
Kusmirek, L1
Tomassoni, G1
Leonelli, F1
Newby, K1
Beheiry, S1
Pacifico, A1
Lydakis, C1
Chaudary, AY1
Lip, GY1
Kariya, N1
Toyoyama, H1
Furuichi, K1
Kubota, H1
Toyoda, Y1
Melenovsky, V1
Wichterle, D1
Malik, J1
Simek, J1
Hradec, J1
Ceska, R1
Malik, M1
Möckel, S1
Egeland, T1
Lorentsen, E1
Come, PC1
Pitt, B1
Bassan, M1
Alpert, JS1
Brandes, W1
Santiago, T1
Limacher, M1
Zeisler, J1
Mehmel, HC1
Paris, PM1
Kaplan, RM1
Stewart, RD1
Weiss, LD1
Smithen, CS1
Bennett, D1
Hudson, RE1
Sowton, E1
Eviatar, A1

Reviews

5 reviews available for nitroglycerin and Bradycardia

ArticleYear
Two cases of Bezold-Jarisch reflex induced by intra-arterial nitroglycerin in critical left main coronary artery stenosis.
    Texas Heart Institute journal, 2013, Volume: 40, Issue:4

    Topics: Aged; Bradycardia; Coronary Angiography; Coronary Stenosis; Coronary Vasospasm; Humans; Hypotension;

2013
The 'vasovagal effect' of nitrates: an under-recognised complication of nitrate use.
    International journal of clinical practice, 1998, Volume: 52, Issue:6

    Topics: Adult; Bradycardia; Humans; Hypotension; Isosorbide Dinitrate; Male; Myocardial Ischemia; Nitroglyce

1998
Nitrate therapy in the elderly.
    The American journal of cardiology, 1990, Jun-04, Volume: 65, Issue:21

    Topics: Aged; Aging; Bradycardia; Coronary Disease; Half-Life; Humans; Hypotension; Isosorbide Dinitrate; Ni

1990
Nitroglycerin-induced hypotension, bradycardia, and asystole: report of a case and review of the literature.
    Clinical cardiology, 1990, Volume: 13, Issue:10

    Topics: Adult; Bradycardia; Electrocardiography; Heart Arrest; Humans; Hypotension; Male; Nitroglycerin

1990
The early phase of acute myocardial infarction: pharmacologic aspects of therapy.
    Annals of internal medicine, 1973, Volume: 78, Issue:6

    Topics: Animals; Atropine; Bradycardia; Death, Sudden; Dogs; Electrocardiography; Glucocorticoids; Heart Rat

1973

Trials

4 trials available for nitroglycerin and Bradycardia

ArticleYear
A mix of aminophylline and heparin plus nitroglycerin can reduce bradycardia during rotational atherectomy on the right coronary artery and dominant circumflex artery.
    Herz, 2023, Volume: 48, Issue:6

    Topics: Aminophylline; Atherectomy, Coronary; Atrioventricular Block; Bradycardia; Coronary Angiography; Cor

2023
Propranolol v. verapamil in the treatment of unstable angina. A double-blind cross-over study.
    European heart journal, 1983, Volume: 4, Issue:3

    Topics: Aged; Analysis of Variance; Angina Pectoris; Blood Pressure; Bradycardia; Clinical Trials as Topic;

1983
Comparison of nadolol, a new long-acting beta-receptor blocking agent, and placebo in the treatment of stable angina pectoris.
    Chest, 1981, Volume: 80, Issue:4

    Topics: Angina Pectoris; Bradycardia; Clinical Trials as Topic; Exercise Test; Fatigue; Humans; Hypotension;

1981
Use of sublingual nitroglycerin during head-up tilt-table testing in patients >60 years of age.
    The American journal of cardiology, 1998, Nov-15, Volume: 82, Issue:10

    Topics: Administration, Sublingual; Aged; Bradycardia; Cardiotonic Agents; Dose-Response Relationship, Drug;

1998

Other Studies

28 other studies available for nitroglycerin and Bradycardia

ArticleYear
ST Elevation During Recovery Phase of Exercise Test.
    The American journal of medicine, 2020, Volume: 133, Issue:11

    Topics: Aged; Bradycardia; Coronary Angiography; Coronary Artery Bypass; Coronary Stenosis; Electrocardiogra

2020
Cardiorespiratory effects induced by 2-nitrate-1,3-dibuthoxypropan are reduced by nitric oxide scavenger in rats.
    Autonomic neuroscience : basic & clinical, 2014, Volume: 181

    Topics: Animals; Arterial Pressure; Bradycardia; Cardiovascular Agents; Consciousness; Dose-Response Relatio

2014
Severe Hypertension and Bradycardia Secondary to Midodrine Overdose.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2017, Volume: 13, Issue:1

    Topics: Adrenergic alpha-1 Receptor Antagonists; Blood Pressure; Bradycardia; Drug Overdose; Female; Glasgow

2017
Neurally Mediated Syncope During Cesarean Delivery: A Case Report.
    A & A case reports, 2017, Mar-01, Volume: 8, Issue:5

    Topics: Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Bradycardia; Cardiopulmonary Resuscitation; Cesa

2017
Persistent atrial fibrillation associated with syncope due to orthostatic hypotension: a case report.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2009, Volume: 10, Issue:11

    Topics: Adult; Atrial Fibrillation; Bradycardia; Electric Countershock; Electrocardiography; Humans; Hypoten

2009
[Therapy of acute myocardial infarct before hospital admission].
    Der Internist, 1982, Volume: 23, Issue:12

    Topics: Aged; Atropine; Bradycardia; Cardiac Complexes, Premature; Diagnosis, Differential; First Aid; Furos

1982
Acute myocardial infarction during continuous electrocardiographic ST segment recording. Possible role of bradycardia and hypotension induced by glyceryl trinitrate.
    British heart journal, 1984, Volume: 51, Issue:5

    Topics: Angina Pectoris; Bradycardia; Electrocardiography; Heart; Humans; Hypotension; Male; Middle Aged; Mo

1984
Nitroglycerin-induced bradycardia and hypotension in acute myocardial infarction.
    Chest, 1980, Volume: 77, Issue:2

    Topics: Aged; Angina Pectoris; Bradycardia; Humans; Hypotension; Male; Myocardial Infarction; Nitroglycerin

1980
Haemodynamic effects of combined nitroglycerin- and dobutamine-infusions after coronary by-pass surgery. With one nitroglycerin-related complication.
    Acta anaesthesiologica Scandinavica, 1980, Volume: 24, Issue:3

    Topics: Adult; Blood Pressure; Bradycardia; Catecholamines; Coronary Artery Bypass; Dobutamine; Drug Therapy

1980
Nitroglycerin-induced hypotension and bradycardia.
    Archives of internal medicine, 1981, Volume: 141, Issue:8

    Topics: Bradycardia; Humans; Hypotension; Nitroglycerin

1981
Syndrome of severe bradycardia and hypotension following sublingual nitroglycerin administration.
    Cardiology, 1981, Volume: 67, Issue:3

    Topics: Aged; Bradycardia; Coronary Disease; Humans; Hypotension; Male; Middle Aged; Nitroglycerin; Syndrome

1981
Nitroglycerin-induced hypotension and bradycardia.
    Archives of internal medicine, 1982, Volume: 142, Issue:2

    Topics: Bradycardia; Humans; Hypotension; Nitroglycerin

1982
Hypotensive and bradycardiac responses to reflex sympathetic inhibition produced by nitroglycerin in rats with sinoaortic deafferentation.
    Journal of cardiovascular pharmacology, 1993, Volume: 21, Issue:1

    Topics: Animals; Atropine; Blood Pressure; Bradycardia; Denervation; Dose-Response Relationship, Drug; Heart

1993
Safety of prehospital nitroglycerin.
    Annals of emergency medicine, 1994, Volume: 23, Issue:1

    Topics: Administration, Sublingual; Adult; Aged; Aged, 80 and over; Bradycardia; Emergencies; Emergency Medi

1994
Evaluation and revision of a vasopressin/nitroglycerin protocol for use in variceal bleeding.
    American journal of critical care : an official publication, American Association of Critical-Care Nurses, 1993, Volume: 2, Issue:3

    Topics: Bradycardia; Clinical Protocols; Constriction, Pathologic; Drug Monitoring; Drug Therapy, Combinatio

1993
Symptomatic bradycardia following the administration of sublingual nitroglycerin.
    The American journal of emergency medicine, 1993, Volume: 11, Issue:3

    Topics: Administration, Sublingual; Bradycardia; Female; Humans; Middle Aged; Nitroglycerin

1993
Coronary artery spasm induced by trigeminal nerve stimulation and vagal reflex during intracranial operation.
    Journal of neurosurgical anesthesiology, 1999, Volume: 11, Issue:3

    Topics: Adrenergic alpha-Agonists; Autonomic Nervous System; Bradycardia; Coronary Vasospasm; Craniotomy; El

1999
Nitroglycerin induced syncope occurs in subjects with delayed phase shift of baroreflex action.
    Pacing and clinical electrophysiology : PACE, 2002, Volume: 25, Issue:5

    Topics: Adult; Baroreflex; Blood Pressure; Blood Pressure Determination; Bradycardia; Electrocardiography; H

2002
[Current treatment of chronic ischemic heart disease].
    Zeitschrift fur arztliche Fortbildung, 1977, Apr-15, Volume: 71, Issue:8

    Topics: Adrenergic beta-Antagonists; Bradycardia; Chronic Disease; Coronary Disease; Humans; Nitroglycerin;

1977
[Uncritical use of nitroglycerin in acute myocardial infarct].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1979, May-20, Volume: 99, Issue:14

    Topics: Angina Pectoris; Bradycardia; Humans; Hypotension; Myocardial Infarction; Nitroglycerin

1979
Nitroglycerin-induced severe hypotension and bradycardia in patients with acute myocardial infarction.
    Circulation, 1976, Volume: 54, Issue:4

    Topics: Aged; Angina Pectoris; Bradycardia; Humans; Hypotension; Male; Middle Aged; Myocardial Infarction; N

1976
Defining the proper role for self-administered sublingual nitroglycerin. A survey of physicians and patients.
    Chest, 1991, Volume: 100, Issue:1

    Topics: Administration, Sublingual; Aged; Attitude; Attitude of Health Personnel; Bradycardia; Data Collecti

1991
Correction: Cimetidine-induced bradycardia.
    DICP : the annals of pharmacotherapy, 1990, Volume: 24, Issue:11

    Topics: Bradycardia; Cimetidine; Humans; Nitroglycerin

1990
[Therapy of acute myocardial infarct].
    Deutsche medizinische Wochenschrift (1946), 1985, May-10, Volume: 110, Issue:19

    Topics: Acidosis; Analgesics; Atropine; Bicarbonates; Bradycardia; Cardiac Complexes, Premature; Critical Ca

1985
Methemoglobin levels following sublingual nitroglycerin in human volunteers.
    Annals of emergency medicine, 1986, Volume: 15, Issue:2

    Topics: Adult; Blood Pressure; Bradycardia; Heart Rate; Humans; Male; Methemoglobinemia; Nitroglycerin; Time

1986
Nitrate therapy in stable angina pectoris.
    The New England journal of medicine, 1988, Jan-14, Volume: 318, Issue:2

    Topics: Angina Pectoris; Bradycardia; Humans; Hypotension; Nitrates; Nitroglycerin; Substance Withdrawal Syn

1988
Trifascicular block--an electrocardiographic, hemodynamic and pathological correlation.
    Journal of electrocardiology, 1971, Volume: 4, Issue:2

    Topics: Angina Pectoris; Atropine; Blood Pressure; Bradycardia; Bundle-Branch Block; Cardiac Catheterization

1971
Severe bradycardia induced by caloric test in cardiac patients.
    The Annals of otology, rhinology, and laryngology, 1970, Volume: 79, Issue:3

    Topics: Acute Disease; Bradycardia; Digoxin; Female; Hearing Disorders; Heart Diseases; Heart Failure; Human

1970