nitroglycerin has been researched along with Bone Fractures in 3 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The nitrates use was not associated with any fracture risk (RR = 0." | 2.82 | The Efficacy of Nitrates for Bone Health: A Systematic Review and Meta-Analysis of Observational and Randomized Controlled Studies. ( Liu, W; Meng, Z; Wang, G, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, W | 1 |
| Meng, Z | 1 |
| Wang, G | 1 |
| Jamal, SA | 1 |
| Hamilton, CJ | 1 |
| Eastell, R | 1 |
| Cummings, SR | 1 |
| Khosla, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Nitrates and Bone Turnover (NABT): Trial to Select the Best Nitrate Preparation[NCT01387672] | Phase 3 | 265 participants (Actual) | Interventional | 2011-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Markers of Bone Formation:~Serum Procollagen type 1 amino- terminal propeptide (P1NP)~Serum Osteocalcin (OC)~Serum Bone-specific alkaline phosphatase (BALP)~Markers of Bone Resorption:~- Serum C-telopeptides of collagen cross-links (CTX)" (NCT01387672)
Timeframe: 3 months
| Intervention | Percent change from baseline (Mean) | |||
|---|---|---|---|---|
| P1NP | OC | BALP | CTX | |
| 0.3 Sublingual (Nitrostat 1) - Treatment Arm 4 | -6.126 | 1.046 | -7.000 | -0.666 |
| 0.6 Sublingual (Nitrostat 2) - Treatment Arm 5 | 2.941 | 1.033 | -3.686 | -1.380 |
| ISMO - Treatment Arm 1 | -4.627 | -3.244 | -5.023 | -5.844 |
| Ointment (Nitrol) - Treatment Arm 3 | -4.297 | -4.481 | -7.426 | -9.699 |
| Patch (Nitro-Dur) - Treatment Arm 2 | -0.405 | 3.796 | -0.541 | -1.025 |
| Placebo Ointment - Treatment Arm 6 | -1.635 | 4.247 | -1.648 | -1.783 |
"Severity of headaches. Subjects recorded the severity of headaches upon awakening every day during the run-in phase using a visual analogue scale (VAS). The scale is represented by a line (continuum) 10 cm long. Subjects were asked to make a vertical line along the continuum to indicate the severity of their headache each morning upon awakening. The score is recorded in cm from 0 to 10. A vertical line marked at 0 means no headache (score recorded = 0), a vertical line marked at 10 means a terrible headache (score recorded = 10)." (NCT01387672)
Timeframe: Run-in phase - 2 days
| Intervention | score on a scale (Mean) | ||||
|---|---|---|---|---|---|
| ISMO | Patch | Ointment | 0.3 Sublingual | 0.6 Sublingual | |
| Run-in Phase | 2.1 | 3.1 | 1.5 | 0.36 | 0.6 |
1 review available for nitroglycerin and Bone Fractures
| Article | Year |
|---|---|
The Efficacy of Nitrates for Bone Health: A Systematic Review and Meta-Analysis of Observational and Randomized Controlled Studies.
Topics: Bone and Bones; Bone Density; Female; Fractures, Bone; Humans; Isosorbide Dinitrate; Male; Nitrates; | 2022 |
1 trial available for nitroglycerin and Bone Fractures
| Article | Year |
|---|---|
Effect of nitroglycerin ointment on bone density and strength in postmenopausal women: a randomized trial.
Topics: Administration, Topical; Aged; Bone Density; Bone Density Conservation Agents; Bone Resorption; Doub | 2011 |
1 other study available for nitroglycerin and Bone Fractures
| Article | Year |
|---|---|
Is nitroglycerin a novel and inexpensive treatment for osteoporosis?
Topics: Animals; Bone Density; Bone Density Conservation Agents; Bone Resorption; Female; Fractures, Bone; H | 2011 |