nitroglycerin has been researched along with Blood Poisoning in 8 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the context of a strict resuscitation protocol, based upon fulfillment of systemic hemodynamic end points in patients with early-phase severe sepsis or septic shock, we conclude that intravenous nitroglycerin does not promote sublingual microcirculatory blood flow." | 9.14 | Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial. ( Bakker, AJ; Boerma, EC; Bruins, N; Buter, H; Egbers, PH; Gerritsen, RT; Ince, C; Kaiferova, K; Kingma, WP; Koetsier, PM; Konijn, A; Koopmans, M; Kuiper, MA; van Roon, EN, 2010) |
| " In contrast, no significant reduction in nitroglycerine-induced vascular relaxation was seen in rats with sepsis irrespective of pentoxifylline treatment." | 7.69 | Pentoxifylline maintains vascular endothelial cell function during hyperdynamic and hypodynamic sepsis. ( Ba, ZF; Chaudry, IH; Wang, P; Wood, TJ, 1996) |
| "In the context of a strict resuscitation protocol, based upon fulfillment of systemic hemodynamic end points in patients with early-phase severe sepsis or septic shock, we conclude that intravenous nitroglycerin does not promote sublingual microcirculatory blood flow." | 5.14 | Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial. ( Bakker, AJ; Boerma, EC; Bruins, N; Buter, H; Egbers, PH; Gerritsen, RT; Ince, C; Kaiferova, K; Kingma, WP; Koetsier, PM; Konijn, A; Koopmans, M; Kuiper, MA; van Roon, EN, 2010) |
| " In contrast, no significant reduction in nitroglycerine-induced vascular relaxation was seen in rats with sepsis irrespective of pentoxifylline treatment." | 3.69 | Pentoxifylline maintains vascular endothelial cell function during hyperdynamic and hypodynamic sepsis. ( Ba, ZF; Chaudry, IH; Wang, P; Wood, TJ, 1996) |
| " Dose-response relaxation curves were determined for acetylcholine (ACh; 10(-8) to 10(-5) M), which stimulates endothelial nitric oxide production, and for nitroglycerine (10(-9) to 10(-6) M), which directly provides nitric oxide in vivo." | 1.29 | A novel nonanticoagulant heparin prevents vascular endothelial cell dysfunction during hyperdynamic sepsis. ( Chaudry, IH; Morrison, AM; Wang, P, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cox, LA | 1 |
| van Eijk, LT | 1 |
| Ramakers, BP | 1 |
| Dorresteijn, MJ | 1 |
| Gerretsen, J | 1 |
| Kox, M | 1 |
| Pickkers, P | 1 |
| Boerma, EC | 1 |
| Koopmans, M | 1 |
| Konijn, A | 1 |
| Kaiferova, K | 1 |
| Bakker, AJ | 1 |
| van Roon, EN | 1 |
| Buter, H | 1 |
| Bruins, N | 1 |
| Egbers, PH | 1 |
| Gerritsen, RT | 1 |
| Koetsier, PM | 1 |
| Kingma, WP | 1 |
| Kuiper, MA | 1 |
| Ince, C | 2 |
| Spronk, PE | 1 |
| Rommes, JH | 1 |
| Schaar, C | 1 |
| Dungel, P | 1 |
| Mittermayr, R | 1 |
| Haindl, S | 1 |
| Osipov, A | 1 |
| Wagner, C | 1 |
| Redl, H | 1 |
| Kozlov, AV | 1 |
| Wang, P | 4 |
| Ba, ZF | 3 |
| Chaudry, IH | 4 |
| Wood, TJ | 2 |
| Zhou, M | 1 |
| Morrison, AM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Evaluation of the Effect of Nitroglycerine Versus Placebo on the Microcirculation by Means of SDF Imaging in Septic Patients on the ICU[NCT00493415] | Phase 3 | 70 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for nitroglycerin and Blood Poisoning
| Article | Year |
|---|---|
Inflammation-induced increases in plasma endocan levels are associated with endothelial dysfunction in humans in vivo.
Topics: Adult; Blood Flow Velocity; Endothelium, Vascular; Endotoxemia; Forearm; Healthy Volunteers; Humans; | 2015 |
Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial.
Topics: Administration, Sublingual; Adult; Aged; Blood Flow Velocity; Cause of Death; Critical Care; Dose-Re | 2010 |
6 other studies available for nitroglycerin and Blood Poisoning
| Article | Year |
|---|---|
Thrombolysis in fulminant purpura: observations on changes in microcirculatory perfusion during successful treatment.
Topics: Ear; Fibrinolytic Agents; Humans; IgA Vasculitis; Ketanserin; Male; Microcirculation; Middle Aged; N | 2006 |
Illumination with blue light reactivates respiratory activity of mitochondria inhibited by nitric oxide, but not by glycerol trinitrate.
Topics: Animals; Cell Respiration; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Light; Male | 2008 |
Nitric oxide. To block or enhance its production during sepsis?
Topics: Acetylcholine; Animals; Aorta, Thoracic; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; Nitr | 1994 |
Inhibition of the biologic activity of tumor necrosis factor maintains vascular endothelial cell function during hyperdynamic sepsis.
Topics: Acetylcholine; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Dr | 1996 |
Pentoxifylline maintains vascular endothelial cell function during hyperdynamic and hypodynamic sepsis.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Endothelium, Vascular; Heart Rate; Male; Nitroglyceri | 1996 |
A novel nonanticoagulant heparin prevents vascular endothelial cell dysfunction during hyperdynamic sepsis.
Topics: Acetylcholine; Animals; Anticoagulants; Aorta; Cecum; Endothelium, Vascular; Heparin, Low-Molecular- | 1996 |