nitroglycerin has been researched along with Anal Fissure in 200 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to determine the optimal dose and dosing interval of nitroglycerin ointment to heal chronic anal fissures." | 10.20 | A study to determine the nitroglycerin ointment dose and dosing interval that best promote the healing of chronic anal fissures. ( Bailey, HR; Beck, DE; Billingham, RP; Binderow, SR; Gibbons, RD; Gottesman, L; Hull, TL; Larach, SW; Margolin, DA; Milsom, JW; Potenti, FM; Rafferty, JF; Riff, DS; Sands, LR; Senagore, A; Stamos, MJ; Yee, LF; Young-Fadok, TM, 2002) |
| "2% nitroglycerin ointment for the treatment of chronic anal fissure." | 9.19 | Internal sphincterotomy versus topical nitroglycerin ointment for chronic anal fissure. ( Aslam, MI; Figueiredo, R; Pervaiz, A, 2014) |
| "To further resolve the clinical equipoise on the choice of chemical sphincterotomy agent for early symptomatic relief of anal fissure by comparing the effectiveness of 2% Diltiazem gel with 0." | 9.19 | Diltiazem vs. glyceryl tri-nitrate for symptomatic relief in anal fissure: a randomised clnical study. ( Azami, R; Mazahir, S; Murtaza, G; Pardhan, A, 2014) |
| " To control for the confounding effects of analgesics, all patients received 650 mg acetaminophen for headache prophylaxis before each application." | 9.17 | Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study. ( Barish, CF; Berry, SM; Bhandari, R; Clark, G; Collins, GV; Howell, J; Pappas, JE; Riff, DS; Safdi, M; Yellowlees, A, 2013) |
| "To compare the symptomatic relief, healing and side-effects of topical diltiazem (DTZ) and glyceryl trinitrate in the treatment of chronic anal fissure." | 9.14 | Topical diltiazem hydrochloride and glyceryl trinitrate in the treatment of chronic anal fissure. ( Jawaid, M; Masood, Z; Salim, M, 2009) |
| "The aim of this study is to compare the ability of three treatments in patients with anal fissure, sphincterotomy, nitroglycerin ointment and combination of gel xylocaine and lactulose." | 9.14 | Prospective clinical trial comparing sphincterotomy, nitroglycerin ointment and xylocaine/lactulose combination for the treatment of anal fissure. ( Basdanis, G; Fahantidis, E; Ioannidis, A; Karamanlis, E; Mekras, A; Michalopoulos, A; Panagiotou, D; Papadopoulos, V, 2010) |
| "To evaluate the efficacy and safety of botulinum toxin A injection compared with topical nitroglycerin ointment for the treatment of chronic anal fissure (CAF)." | 9.12 | Efficacy and safety of botulinum toxin a injection compared with topical nitroglycerin ointment for the treatment of chronic anal fissure: a prospective randomized study. ( Bauerfeind, P; Fried, M; Fruehauf, H; Thumshirn, M; Wegmueller, B, 2006) |
| "Although treatment with either topical nitroglycerin or botulinum toxin is effective as an alternative to surgery for patients with chronic anal fissure, botulinum toxin is the more effective option." | 9.12 | Randomized clinical trial comparing botulinum toxin injections with 0.2 per cent nitroglycerin ointment for chronic anal fissure. ( Brandara, F; Brisinda, G; Cadeddu, F; Maria, G; Marniga, G, 2007) |
| "After six years of follow-up, it seems that lateral internal sphincterotomy is a more durable treatment for chronic anal fissure compared with topical nitroglycerin therapy and does not compromise long-term fecal continence." | 9.12 | Lateral internal sphincterotomy is superior to topical nitroglycerin for healing chronic anal fissure and does not compromise long-term fecal continence: six-year follow-up of a multicenter, randomized, controlled trial. ( Brown, CJ; Dubreuil, D; Liu, M; McLeod, RS; O'Connor, BI; Santoro, L, 2007) |
| "According to our study, there was no benefit regarding healing or pain relief, in treating patients suffering from an anal fissure with Nitroglycerin ointment in combination with stool softeners and sitz baths, compared to the same treatment without Nitroglycerin ointment." | 9.11 | [A prospective, randomized double-blind study on the treatment of anal fissures with Nitroglycerin ointment]. ( Gelertner, I; Halevy, A; Levy, N; Negri, M; Weinstein, D; Ziv, Y, 2004) |
| "Topical nitroglycerin (GTN) is one of the medical treatments of choice in chronic anal fissure." | 9.11 | Topical nitroglycerin versus lateral internal sphincterotomy for chronic anal fissure: prospective, randomized trial. ( Hadke, NS; Maan, MS; Mishra, R; Thomas, S, 2005) |
| "The aim of this study was to compare prospectively diltiazem with GTN ointment in the treatment of anal fissure." | 9.10 | A prospective randomized trial of diltiazem and glyceryltrinitrate ointment in the treatment of chronic anal fissure. ( Bielecki, K; Kolodziejczak, M, 2003) |
| "Although treatment with either topical nitroglycerin or botulinum toxin is effective as an alternative to surgery for patients with chronic anal fissure, botulinum toxin is the more effective nonsurgical treatment." | 9.09 | A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. ( Albanese, A; Bentivoglio, AR; Brisinda, G; Cassetta, E; Gui, D; Maria, G, 1999) |
| "This was a multicenter, randomized, controlled trial to compare the effectiveness of topical nitroglycerin with internal sphincterotomy in the treatment of chronic anal fissure." | 9.09 | Internal sphincterotomy is superior to topical nitroglycerin in the treatment of chronic anal fissure: results of a randomized, controlled trial by the Canadian Colorectal Surgical Trials Group. ( Buie, D; Burnstein, M; Burul, C; Gregoire, R; McLeod, RS; Mukraj, D; O'Connor, BI; Plewes, EA; Reznick, R; Richard, CS; Ross, T; Silverman, R, 2000) |
| "Topical application of nitroglycerine represents a new, easily handled, and effective alternative in the treatment of anal fissures." | 9.08 | Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy? ( Bacher, H; Cerwenka, H; El-Shabrawi, A; Mischinger, HJ; Pfeifer, J; Schweiger, W; Werkgartner, G, 1997) |
| "The study analyzed clinical trials investigating the effectiveness of diltiazem (DTZ) and glyceryltrinitrate (GTN) for the nonsurgical management of chronic anal fissure (CAF)." | 8.89 | Systematic review of the use of topical diltiazem compared with glyceryltrinitrate for the nonoperative management of chronic anal fissure. ( Baig, MK; Sains, P; Sajid, MS; Whitehouse, PA, 2013) |
| "The objective of this review is to systematically analyze the prospective randomized controlled trials on the effectiveness of diltiazem (DTZ) and glyceryltrinitrate (GTN) for the pharmacological management of chronic anal fissure (CAF)." | 8.84 | The efficacy of diltiazem and glyceryltrinitrate for the medical management of chronic anal fissure: a meta-analysis. ( Baig, MK; Cheek, E; Rimple, J; Sajid, MS, 2008) |
| "4% Nitroglycerin ointment is an intra-anal formulation of nitroglycerin (glyceryl trinitrate) indicated for the treatment of chronic anal fissure pain." | 8.83 | 0.4% nitroglycerin ointment : in the treatment of chronic anal fissure pain. ( Easthope, SE; Fenton, C; Wellington, K, 2006) |
| "This study explores the evidence-based background for treating chronic anal fissure with topically applied nitroglycerin (NTG): in part the general effect of NTG and in part how its effect compares to that of surgery, which has been claimed to have long-term complications like incontinence for flatus and faeces." | 8.81 | [Treatment of chronic anal fissure with topically applied nitroglycerin ointment. A systematic review of evidence-based results]. ( Matzen, P; Svendsen, CB, 2002) |
| "To compare the results of subcutaneous internal lateral sphincterotomy under local anesthesia and nitroglycerin ointment treatments in acute and chronic anal fissures." | 7.76 | Subcutaneous internal lateral sphincterotomy (SILS) versus nitroglycerine ointment in anal fissure: a prospective study. ( Dar, TI; Khan, A; Malik, AA; Parray, FQ; Rather, AA; Rather, SA; Wani, RA, 2010) |
| "2% glycerl trinitrate (GTN) and topical 2% diltiazem (DTZ), in the management of chronic anal fissure." | 7.75 | Diltiazem (2%) versus glyceryl trinitrate cream (0.2%) in the management of chronic anal fissure. ( Hashmi, F; Siddiqui, FG, 2009) |
| "Both topical diltiazem, a calcium channel blocker, and glyceryl trinitrate, a nitric oxide donor, lower anal pressure and heal two-thirds of chronic anal fissures." | 7.71 | Diltiazem heals glyceryl trinitrate-resistant chronic anal fissures: a prospective study. ( Jonas, M; Scholefield, JH; Speake, W, 2002) |
| "2% nitroglycerin (GTN) ointment (Rectogesic) compared with lateral internal sphincterotomy in the treatment of a chronic anal fissure in the United Kingdom (UK), from the perspective of the National Health Service (NHS)." | 7.71 | Modelling the economic impact of managing a chronic anal fissure with a proprietary formulation of nitroglycerin (Rectogesic) compared to lateral internal sphincterotomy in the United Kingdom. ( Christie, A; Guest, JF, 2002) |
| "Topical nitroglycerin was only effective in approximately one-half of patients with an anal fissure." | 7.70 | Nitroglycerin ointment for anal fissures: effective treatment or just a headache? ( Cataldo, PA; Hyman, NH, 1999) |
| "Anal fissure is the most common anal disease in children." | 6.84 | Efficacy of nitroglycerine ointment in the treatment of pediatric anal fissure. ( Al-Mayoof, AF; Joda, AE, 2017) |
| "Diltiazem gel was found to be superior to Glyceril trinitrate ointment due to significantly higher healing rate and fewer side-effects." | 6.77 | Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double-blind trial. ( Ala, S; Ghorbanian, A; Hadianamrei, R; Saeedi, M, 2012) |
| "Diltiazem ointment was found to be superior regarding pain relief, fewer side effects, and late recurrence as compared with GTN ointment." | 6.73 | A comparison of the effects of diltiazem and glyceryl trinitrate ointment in the treatment of chronic anal fissure: a randomized clinical trial. ( Jain, BK; Kumar, P; Saifee, Y; Shrivastava, UK, 2007) |
| "Nitroglycerin or placebo was administered in two daily applications for two weeks." | 6.70 | Long-term results of topical nitroglycerin in the treatment of chronic anal fissures are disappointing. ( Bisisio, O; Graziano, A; Gualdrini, U; Lencinas, S; Masciangioli, G; Svidler López, L, 2001) |
| "Anal fissure is a painful condition that is caused by anodermal tearing after the passage of hard stool." | 6.41 | Treatment of anal fissures with topical nitroglycerin. ( Ehrenpreis, ED; Ginsburg, PM; Meyers, JS; Rubin, DT, 2001) |
| "The aim of this study was to determine the optimal dose and dosing interval of nitroglycerin ointment to heal chronic anal fissures." | 6.20 | A study to determine the nitroglycerin ointment dose and dosing interval that best promote the healing of chronic anal fissures. ( Bailey, HR; Beck, DE; Billingham, RP; Binderow, SR; Gibbons, RD; Gottesman, L; Hull, TL; Larach, SW; Margolin, DA; Milsom, JW; Potenti, FM; Rafferty, JF; Riff, DS; Sands, LR; Senagore, A; Stamos, MJ; Yee, LF; Young-Fadok, TM, 2002) |
| "Many patients with chronic migraine are difficult to treat." | 5.56 | Chronic Migraine With Apparent Loss of Response to Onabotulinum Toxin Type A Due to Local Nitroglycerin Treatment for an Anal Fissure: A Case Report. ( González-Quintanilla, V; Madera, J; Pascual, J; Pérez-Pereda, S, 2020) |
| "Nitroglycerin (NTG) was complexed with β-cyclodextrin (β-CD) to provide prolonged NTG release, with the intention of decreasing systemic drug absorption and thus reducing side effects." | 5.39 | Modified-release ointment with nitroglycerin β-cyclodextrin inclusion complex for treatment of anal fissures. ( Centkowska, K; Sznitowska, M, 2013) |
| "Anal sphincter spasm is a common finding in patients with anal fissure disease." | 5.30 | Topical nitroglycerin in the management of anal fissure: an explosive outcome! ( Cooperman, H; Fleshner, P; Manookian, CM; Moore, B; Sokol, T; Teng, F, 1998) |
| "To determine whether the medical Treatment of anal fissure can be an effective alternative for surgery Methods: Retrospectively, we randomly selected 190 Patients being treated for anal fissure between the years 2005-2010 in 3 equal groups: group A: Patients who received medical treatment with topical nitroglycerin, group B: Patient treated with topical diltiazem, and group C: Patients underwent surgery." | 5.22 | Chronic Anal Fissure: A Comparative Study of Medical Treatment Versus Surgical Sphincterotomy. ( Hashemi, P; Motie, MR, 2016) |
| "2% nitroglycerin ointment for the treatment of chronic anal fissure." | 5.19 | Internal sphincterotomy versus topical nitroglycerin ointment for chronic anal fissure. ( Aslam, MI; Figueiredo, R; Pervaiz, A, 2014) |
| "To further resolve the clinical equipoise on the choice of chemical sphincterotomy agent for early symptomatic relief of anal fissure by comparing the effectiveness of 2% Diltiazem gel with 0." | 5.19 | Diltiazem vs. glyceryl tri-nitrate for symptomatic relief in anal fissure: a randomised clnical study. ( Azami, R; Mazahir, S; Murtaza, G; Pardhan, A, 2014) |
| " To control for the confounding effects of analgesics, all patients received 650 mg acetaminophen for headache prophylaxis before each application." | 5.17 | Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study. ( Barish, CF; Berry, SM; Bhandari, R; Clark, G; Collins, GV; Howell, J; Pappas, JE; Riff, DS; Safdi, M; Yellowlees, A, 2013) |
| "Application of nitroglycerin (glyceryl trinitrate) ointment with perianal administration is a widely used treatment for chronic anal fissure." | 5.16 | Perianal versus endoanal application of glyceryl trinitrate 0.4% ointment in the treatment of chronic anal fissure: results of a randomized controlled trial. Is this the solution to the headaches? ( Arroyo, A; Calpena, R; Candela, F; Frangi, A; Moya, P; Oliver, MI; Pérez-Legaz, J; Ruiz-Tovar, J, 2012) |
| "The present study aims to evaluate and compare the efficacy of two nitrate gels, containing isosorbide-5-mononitrate (ISMN) or glyceryl trinitrate (GTN), in the therapy of chronic anal fissure." | 5.14 | Topical anal fissure treatment: placebo-controlled study of mononitrate and trinitrate therapies. ( Doytchinova, I; Kovatchki, D; Tankova, L; Yoncheva, K, 2009) |
| "To compare the symptomatic relief, healing and side-effects of topical diltiazem (DTZ) and glyceryl trinitrate in the treatment of chronic anal fissure." | 5.14 | Topical diltiazem hydrochloride and glyceryl trinitrate in the treatment of chronic anal fissure. ( Jawaid, M; Masood, Z; Salim, M, 2009) |
| "The aim of this study is to compare the ability of three treatments in patients with anal fissure, sphincterotomy, nitroglycerin ointment and combination of gel xylocaine and lactulose." | 5.14 | Prospective clinical trial comparing sphincterotomy, nitroglycerin ointment and xylocaine/lactulose combination for the treatment of anal fissure. ( Basdanis, G; Fahantidis, E; Ioannidis, A; Karamanlis, E; Mekras, A; Michalopoulos, A; Panagiotou, D; Papadopoulos, V, 2010) |
| "Topical nitroglycerin has been widely used as a means for avoiding surgery in patients with anal fissure." | 5.12 | Controlled dose delivery in topical treatment of anal fissure: pilot study of a new paradigm. ( Salgado, G; Torrabadella, L, 2006) |
| "To evaluate the efficacy and safety of botulinum toxin A injection compared with topical nitroglycerin ointment for the treatment of chronic anal fissure (CAF)." | 5.12 | Efficacy and safety of botulinum toxin a injection compared with topical nitroglycerin ointment for the treatment of chronic anal fissure: a prospective randomized study. ( Bauerfeind, P; Fried, M; Fruehauf, H; Thumshirn, M; Wegmueller, B, 2006) |
| "Although treatment with either topical nitroglycerin or botulinum toxin is effective as an alternative to surgery for patients with chronic anal fissure, botulinum toxin is the more effective option." | 5.12 | Randomized clinical trial comparing botulinum toxin injections with 0.2 per cent nitroglycerin ointment for chronic anal fissure. ( Brandara, F; Brisinda, G; Cadeddu, F; Maria, G; Marniga, G, 2007) |
| "After six years of follow-up, it seems that lateral internal sphincterotomy is a more durable treatment for chronic anal fissure compared with topical nitroglycerin therapy and does not compromise long-term fecal continence." | 5.12 | Lateral internal sphincterotomy is superior to topical nitroglycerin for healing chronic anal fissure and does not compromise long-term fecal continence: six-year follow-up of a multicenter, randomized, controlled trial. ( Brown, CJ; Dubreuil, D; Liu, M; McLeod, RS; O'Connor, BI; Santoro, L, 2007) |
| "According to our study, there was no benefit regarding healing or pain relief, in treating patients suffering from an anal fissure with Nitroglycerin ointment in combination with stool softeners and sitz baths, compared to the same treatment without Nitroglycerin ointment." | 5.11 | [A prospective, randomized double-blind study on the treatment of anal fissures with Nitroglycerin ointment]. ( Gelertner, I; Halevy, A; Levy, N; Negri, M; Weinstein, D; Ziv, Y, 2004) |
| "Topical nitroglycerin (GTN) is one of the medical treatments of choice in chronic anal fissure." | 5.11 | Topical nitroglycerin versus lateral internal sphincterotomy for chronic anal fissure: prospective, randomized trial. ( Hadke, NS; Maan, MS; Mishra, R; Thomas, S, 2005) |
| "The aim of this study was to compare prospectively diltiazem with GTN ointment in the treatment of anal fissure." | 5.10 | A prospective randomized trial of diltiazem and glyceryltrinitrate ointment in the treatment of chronic anal fissure. ( Bielecki, K; Kolodziejczak, M, 2003) |
| "Although treatment with either topical nitroglycerin or botulinum toxin is effective as an alternative to surgery for patients with chronic anal fissure, botulinum toxin is the more effective nonsurgical treatment." | 5.09 | A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure. ( Albanese, A; Bentivoglio, AR; Brisinda, G; Cassetta, E; Gui, D; Maria, G, 1999) |
| "This was a multicenter, randomized, controlled trial to compare the effectiveness of topical nitroglycerin with internal sphincterotomy in the treatment of chronic anal fissure." | 5.09 | Internal sphincterotomy is superior to topical nitroglycerin in the treatment of chronic anal fissure: results of a randomized, controlled trial by the Canadian Colorectal Surgical Trials Group. ( Buie, D; Burnstein, M; Burul, C; Gregoire, R; McLeod, RS; Mukraj, D; O'Connor, BI; Plewes, EA; Reznick, R; Richard, CS; Ross, T; Silverman, R, 2000) |
| "Topical application of nitroglycerine represents a new, easily handled, and effective alternative in the treatment of anal fissures." | 5.08 | Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy? ( Bacher, H; Cerwenka, H; El-Shabrawi, A; Mischinger, HJ; Pfeifer, J; Schweiger, W; Werkgartner, G, 1997) |
| "The study analyzed clinical trials investigating the effectiveness of diltiazem (DTZ) and glyceryltrinitrate (GTN) for the nonsurgical management of chronic anal fissure (CAF)." | 4.89 | Systematic review of the use of topical diltiazem compared with glyceryltrinitrate for the nonoperative management of chronic anal fissure. ( Baig, MK; Sains, P; Sajid, MS; Whitehouse, PA, 2013) |
| "The objective of this review is to systematically analyze the prospective randomized controlled trials on the effectiveness of diltiazem (DTZ) and glyceryltrinitrate (GTN) for the pharmacological management of chronic anal fissure (CAF)." | 4.84 | The efficacy of diltiazem and glyceryltrinitrate for the medical management of chronic anal fissure: a meta-analysis. ( Baig, MK; Cheek, E; Rimple, J; Sajid, MS, 2008) |
| "4% Nitroglycerin ointment is an intra-anal formulation of nitroglycerin (glyceryl trinitrate) indicated for the treatment of chronic anal fissure pain." | 4.83 | 0.4% nitroglycerin ointment : in the treatment of chronic anal fissure pain. ( Easthope, SE; Fenton, C; Wellington, K, 2006) |
| "Twenty one different comparisons of medical therapies to heal anal fissure have been reported in 31 trials, including 9 agents-glyceryl trinitrate, isosorbide dinitrate, botulinum toxin, diltiazem, nifedipine, hydrocortisone, lidocaine, bran, placebo-as well as anal dilators and surgical sphincterotomy." | 4.82 | A systematic review of medical therapy for anal fissure. ( Nelson, R, 2004) |
| "This study explores the evidence-based background for treating chronic anal fissure with topically applied nitroglycerin (NTG): in part the general effect of NTG and in part how its effect compares to that of surgery, which has been claimed to have long-term complications like incontinence for flatus and faeces." | 4.81 | [Treatment of chronic anal fissure with topically applied nitroglycerin ointment. A systematic review of evidence-based results]. ( Matzen, P; Svendsen, CB, 2002) |
| " Local application of nitroglycerin is very safe and can be used by physicians in general practice for chronic anal fissure." | 4.81 | [Nitric oxide donors and their potentiating effects after botulinum toxin application for treatment of chronic anal fissure]. ( Adrich, Z; Kryszewski, A; Madaliński, M, 2002) |
| " Besides an anal fissure in the past, which responded to nitroglycerin ointment, his medical history was unremarkable." | 4.31 | Causes and Management of Pruritus Ani. ( Beresneva, O; Sacks, OA, 2023) |
| "To compare the results of subcutaneous internal lateral sphincterotomy under local anesthesia and nitroglycerin ointment treatments in acute and chronic anal fissures." | 3.76 | Subcutaneous internal lateral sphincterotomy (SILS) versus nitroglycerine ointment in anal fissure: a prospective study. ( Dar, TI; Khan, A; Malik, AA; Parray, FQ; Rather, AA; Rather, SA; Wani, RA, 2010) |
| "2% glycerl trinitrate (GTN) and topical 2% diltiazem (DTZ), in the management of chronic anal fissure." | 3.75 | Diltiazem (2%) versus glyceryl trinitrate cream (0.2%) in the management of chronic anal fissure. ( Hashmi, F; Siddiqui, FG, 2009) |
| "Both topical diltiazem, a calcium channel blocker, and glyceryl trinitrate, a nitric oxide donor, lower anal pressure and heal two-thirds of chronic anal fissures." | 3.71 | Diltiazem heals glyceryl trinitrate-resistant chronic anal fissures: a prospective study. ( Jonas, M; Scholefield, JH; Speake, W, 2002) |
| "2% nitroglycerin (GTN) ointment (Rectogesic) compared with lateral internal sphincterotomy in the treatment of a chronic anal fissure in the United Kingdom (UK), from the perspective of the National Health Service (NHS)." | 3.71 | Modelling the economic impact of managing a chronic anal fissure with a proprietary formulation of nitroglycerin (Rectogesic) compared to lateral internal sphincterotomy in the United Kingdom. ( Christie, A; Guest, JF, 2002) |
| "Topical nitroglycerin was only effective in approximately one-half of patients with an anal fissure." | 3.70 | Nitroglycerin ointment for anal fissures: effective treatment or just a headache? ( Cataldo, PA; Hyman, NH, 1999) |
| " This report documents a therapeutic role for nitroglycerin, a nitric oxide donor, in the treatment of acutely thrombosed external hemorrhoids and anal fissure." | 3.69 | Treatment of benign anal disease with topical nitroglycerin. ( Gorfine, SR, 1995) |
| " The secondary outcomes recorded at the same time points were healing rate, visual analogue scales for itching and burning, rate of complications and adverse events, patient quality of life and satisfaction, and cost analysis." | 3.30 | Efficacy and safety of Propionibacterium extract gel versus glyceryl trinitrate ointment in the treatment of chronic anal fissure: a randomized controlled trial. ( Altomare, DF; Cantarella, F; Currò, G; Fulginiti, S; Gallo, G; Grossi, U; La Torre, M; Rinaldi, M; Santoro, GA; Tierno, S; Tomasicchio, G; Trompetto, M; Vanini, P, 2023) |
| "Anal fissure is one of the most common benign anal disorders, and medical treatments play an important role in its management." | 3.01 | Short-term Results of Platelet-Rich Plasma in the Treatment of Chronic Anal Fissure: Randomized Controlled Clinical Study. ( Tanrikulu, Y; Yilmaz, G, 2021) |
| "Anal fissure is the most common anal disease in children." | 2.84 | Efficacy of nitroglycerine ointment in the treatment of pediatric anal fissure. ( Al-Mayoof, AF; Joda, AE, 2017) |
| "Anal fissure is a common condition that can be treated medically or surgically." | 2.82 | A systematic review and meta-analysis of the efficacy of topical sphincterotomy treatments for anal fissure. ( Connolly, A; Hardy, MO; Hill, AG; Jin, JZ; Mauiliu-Wallis, M; Singh, PP; Unasa, H; Weston, M, 2022) |
| "Diltiazem gel was found to be superior to Glyceril trinitrate ointment due to significantly higher healing rate and fewer side-effects." | 2.77 | Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double-blind trial. ( Ala, S; Ghorbanian, A; Hadianamrei, R; Saeedi, M, 2012) |
| "Chronic anal fissure is a common benign disorder; for this condition, lateral internal sphincterotomy is the "gold standard" of treatment." | 2.74 | Glyceryl trinitrate ointment (0.25%) and anal cryothermal dilators in the treatment of chronic anal fissures. ( Munegato, G; Schiano di Visconte, M, 2009) |
| "Anal fissure is associated with hypertonia of the internal anal sphincter and pain." | 2.74 | [Topical use of glyceryl-trinitrate in the treatment of anal fissure]. ( Corno, F; Marano, A; Mistrangelo, P; Volpatto, S, 2009) |
| "Diltiazem ointment was found to be superior regarding pain relief, fewer side effects, and late recurrence as compared with GTN ointment." | 2.73 | A comparison of the effects of diltiazem and glyceryl trinitrate ointment in the treatment of chronic anal fissure: a randomized clinical trial. ( Jain, BK; Kumar, P; Saifee, Y; Shrivastava, UK, 2007) |
| "It is a safe and an effective treatment of anal fissure in a South Asian population." | 2.73 | Comparison of topical glyceryl trinitrate with lignocaine ointment for treatment of anal fissure: a randomised controlled trial. ( Ahmad, J; Andrabi, SI; Rathore, MA, 2007) |
| "This study addressed the dose-response to three different concentrations of GTN ointment compared with placebo in a double blind randomised controlled trial." | 2.71 | A dose finding study with 0.1%, 0.2%, and 0.4% glyceryl trinitrate ointment in patients with chronic anal fissures. ( Athanasiadis, S; Bock, JU; Herold, A; Marla, B; Pröls, M; Richter, HJ; Scholefield, JH, 2003) |
| "Anal fissure was completely healed in 38 (73%) and 24 (64%) of the patients after 6 weeks and 48 (81%) and 27 (79%) of the patients in transdermal group and ointment group, respectively." | 2.71 | A randomised study comparing systemic transdermal treatment and local application of glyceryl trinitrate ointment in the management of chronic anal fissure. ( Colak, T; Dirlik, M; Ipek, T; Kanik, A; Urkaya, N, 2003) |
| " However, because the physiologic response has resolved in fewer than 20 minutes, the dosing regime should be reassessed." | 2.71 | Manometric effect of topical glyceryl trinitrate and its impact on chronic anal fissure healing. ( Kennedy, ML; King, DW; Thornton, MJ, 2005) |
| "Nitroglycerin or placebo was administered in two daily applications for two weeks." | 2.70 | Long-term results of topical nitroglycerin in the treatment of chronic anal fissures are disappointing. ( Bisisio, O; Graziano, A; Gualdrini, U; Lencinas, S; Masciangioli, G; Svidler López, L, 2001) |
| "Significant recurrence of symptomatic fissures and a high incidence of headaches are limitations of the treatment." | 2.69 | Randomised controlled trial shows that glyceryl trinitrate heals anal fissures, higher doses are not more effective, and there is a high recurrence rate. ( Carapeti, EA; Chadwick, SJ; Kamm, MA; McDonald, PJ; Melville, D; Phillips, RK, 1999) |
| "Pain was recorded on a linear analog scale." | 2.69 | Glyceryl trinitrate ointment for the treatment of chronic anal fissure: results of a placebo-controlled trial and long-term follow-up. ( Kennedy, ML; Lubowski, DZ; Nguyen, H; Sowter, S, 1999) |
| "Internal anal sphincterotomy for treating chronic anal fissure can irreversibly damage anal continence." | 2.69 | Glyceryl trinitrate for chronic anal fissure--healing or headache? Results of a multicenter, randomized, placebo-controled, double-blind trial. ( Altomare, DF; Arcanà, F; Bottini, C; Lovreglio, R; Milito, G; Nardelli, N; Pescatori, M; Pulvirenti-D'Urso, A; Rinaldi, M; Scardigno, D; Spinelli, F, 2000) |
| "Chronic anal fissure is a frequent and troubling condition, that may need surgical sphincterotomy for relief of symptoms." | 2.69 | Double-blind manometric assessment of two topical glyceryl trinitrate formulations in patients with chronic anal fissures. ( Bassotti, G; Ceccarelli, F; Clementi, M; Pelli, MA, 2000) |
| "Anal fissure is most commonly treated surgically by internal anal sphincterotomy." | 2.68 | A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure. ( Lund, JN; Scholefield, JH, 1997) |
| "Four recurrences were successfully treated by further GTN ointment and one by sphincterotomy." | 2.68 | Glyceryl trinitrate is an effective treatment for anal fissure. ( Lund, JN; Scholefield, JH, 1997) |
| "It is important to treat constipation to avoid recurrent tears in the anal canal." | 2.66 | Anal Fissure in Children. ( Patkova, B; Wester, T, 2020) |
| "Anal fissure has a very large number of treatment options." | 2.55 | A systematic review and meta-analysis of the treatment of anal fissure. ( Bravo, A; Castillo, D; Gumienny, C; Manuel, D; Nelson, RL; Patel, K; Schmitt, K; Spencer, B; Yeboah-Sampong, A, 2017) |
| "Anal stenosis is a challenging problem most commonly resulting from trauma, such as excisional hemorrhoidectomy." | 2.49 | Anal fissure and stenosis. ( Costedio, M; Shawki, S, 2013) |
| "Anal fissure is one of the most common and painful proctologic diseases." | 2.47 | The management of patients with primary chronic anal fissure: a position paper. ( Altomare, DF; Binda, GA; Canuti, S; Landolfi, V; Trompetto, M; Villani, RD, 2011) |
| "Anal fissure is a common disorder that is effectively treated and prevented with conservative measures in its acute form, whereas chronic fissures may require medical or surgical therapy." | 2.46 | Anal fissure. ( Herzig, DO; Lu, KC, 2010) |
| "Anal fissures are a common cause of anal pain during, and for 1 to 2 hours after, defecation." | 2.46 | Anal fissure (chronic). ( Nelson, R, 2010) |
| "Smooth muscle relaxation is well tolerated, can be administered on an outpatient basis, does not cause any lesion of the continence organ, and subsequently, does not lead to any permanent latent or apparent fecal incontinence." | 2.44 | Nonsurgical approaches for the treatment of anal fissures. ( Chopra, S; Dhawan, S, 2007) |
| "Anal fissures are commonly encountered in routine colorectal practice." | 2.44 | Modern perspectives in the treatment of chronic anal fissures. ( Bhardwaj, R; Parker, MC, 2007) |
| "Chronic anal fissure is a common benign disorder that causes severe, sharp anal pain during defaecation." | 2.43 | Anal fissure: the changing management of a surgical condition. ( Acheson, AG; Scholefield, JH, 2005) |
| "Anal fissure is a common disorder which may cause symptoms at any age." | 2.43 | Chemical sphincterotomy--first line of treatment for chronic anal fissure. ( Baten, MA; Chowdhury, RA; Haq, Z; Khatun, M; Rahman, M, 2005) |
| "Chronic anal fissure is a tear in the lining of the anal canal that, if not treated appropriately at an early stage, causes considerable anal pain during defaecation." | 2.43 | Pharmacological advancements in the treatment of chronic anal fissure. ( Acheson, AG; Scholefield, JH, 2005) |
| "Therefore, pharmacological means to treat chronic anal fissures have been explored." | 2.42 | Concepts in pathogenesis and treatment of chronic anal fissure--a review of the literature. ( Buhr, HJ; Kroesen, AJ; Utzig, MJ, 2003) |
| "Anal fissures are common conditions, presenting with bleeding, itching, and pain of varying severity." | 2.41 | Anal fissures. ( Lubowski, DZ, 2000) |
| "Anal fissure is a painful condition that is caused by anodermal tearing after the passage of hard stool." | 2.41 | Treatment of anal fissures with topical nitroglycerin. ( Ehrenpreis, ED; Ginsburg, PM; Meyers, JS; Rubin, DT, 2001) |
| "Chronic anal fissure is a common and painful condition associated with internal anal sphincter hypertonia." | 2.41 | Progress in the understanding and treatment of chronic anal fissure. ( Gardiner, KR; McCallion, K, 2001) |
| "Anal fissure is one of the most common and painful proctological pathologies affecting mainly young individuals." | 2.40 | Fissure-in-ano, to divide or not to divide? ( Brugman, T; Bruyninx, L; Jacquet, NJ, 1999) |
| "Many patients with chronic migraine are difficult to treat." | 1.56 | Chronic Migraine With Apparent Loss of Response to Onabotulinum Toxin Type A Due to Local Nitroglycerin Treatment for an Anal Fissure: A Case Report. ( González-Quintanilla, V; Madera, J; Pascual, J; Pérez-Pereda, S, 2020) |
| "Pain and constipation were assessed prior to treatment and at 6 weeks after therapy using visual analogue scale (VAS) and Wexner constipation score." | 1.46 | Does the duration of symptoms of anal fissure impact its response to conservative treatment? A prospective cohort study. ( Abdelmawla, AA; Abdelnaby, M; Elfeki, H; Elgendy, H; Emile, SH; Khafagy, W; Magdy, A, 2017) |
| "Nitroglycerin (NTG) was complexed with β-cyclodextrin (β-CD) to provide prolonged NTG release, with the intention of decreasing systemic drug absorption and thus reducing side effects." | 1.39 | Modified-release ointment with nitroglycerin β-cyclodextrin inclusion complex for treatment of anal fissures. ( Centkowska, K; Sznitowska, M, 2013) |
| "(1) Anal fissures are very painful but often heal spontaneously." | 1.35 | 0.4% glyceryl trinitrate ointment: new drug. Not useful for anal fissures. ( , 2008) |
| "Although headache is a frequent side-effect, it is usually transient and glyceryl trinitrate does not seem to have any long-term adverse effects." | 1.35 | [The role of glyceryl trinitrate in the treatment of anal fissure]. ( Bursics, A; Takáts, K; Tóth, A, 2008) |
| "Guidelines for the treatment of anal fissure have been published in the USA and UK but differ." | 1.33 | An evidence-based treatment algorithm for anal fissure. ( Coremans, G; Herold, A; Karaitianos, I; Lund, JN; Nyström, PO; Pescatori, M; Schouten, WR; Sebastian, AA; Spyrou, M, 2006) |
| "The anal fissure is one of the most frequent causes for anal pain." | 1.31 | [Anal fissure--a new therapy concept]. ( Baumann, M; Hetzer, FH; Röthlin, M, 2000) |
| "Anal sphincter spasm is a common finding in patients with anal fissure disease." | 1.30 | Topical nitroglycerin in the management of anal fissure: an explosive outcome! ( Cooperman, H; Fleshner, P; Manookian, CM; Moore, B; Sokol, T; Teng, F, 1998) |
| "There has been an emerging trend to treat chronic anal fissures by pharmacologic means." | 1.30 | Treatment of chronic anal fissure with topical glyceryl trinitrate. ( Dorfman, G; Levitt, M; Platell, C, 1999) |
| "The aetiology of anal fissure is unclear, but there is an association with high maximum resting pressure (MRP)." | 1.29 | Topical glyceryl trinitrate in the treatment of chronic anal fissure. ( Kamm, MA; Nicholls, RJ; Phillips, RK; Watson, SJ, 1996) |
| "Anal fissure is often treated surgically by sphincterotomy." | 1.29 | Use of glyceryl trinitrate ointment in the treatment of anal fissure. ( Armitage, NC; Lund, JN; Scholefield, JH, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 41 (20.50) | 18.2507 |
| 2000's | 112 (56.00) | 29.6817 |
| 2010's | 30 (15.00) | 24.3611 |
| 2020's | 17 (8.50) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, JZ | 1 |
| Hardy, MO | 1 |
| Unasa, H | 1 |
| Mauiliu-Wallis, M | 1 |
| Weston, M | 1 |
| Connolly, A | 1 |
| Singh, PP | 1 |
| Hill, AG | 1 |
| Ruiz-Tovar, J | 4 |
| Llavero, C | 2 |
| Phillips, PF | 1 |
| Soriano, LF | 1 |
| Buckley, DA | 1 |
| Garg, P | 1 |
| Mustafa, G | 1 |
| Hossain, MS | 1 |
| Sheikh, SH | 1 |
| Faruk, I | 1 |
| Taher, MA | 1 |
| Ferdaus, AM | 1 |
| Fatema, B | 1 |
| Alam, A | 1 |
| Tasnim, T | 1 |
| Sacks, OA | 2 |
| Beresneva, O | 2 |
| Sierra-Arango, F | 1 |
| de la Hoz-Valle, J | 1 |
| Espinosa, JP | 1 |
| Moreno-Montoya, J | 1 |
| Vásquez Roldan, M | 1 |
| Pérez-Riveros, ED | 1 |
| Fagan, C | 1 |
| Kolber, MR | 1 |
| Lindblad, AJ | 1 |
| Gallo, G | 1 |
| Trompetto, M | 2 |
| Fulginiti, S | 1 |
| La Torre, M | 1 |
| Tierno, S | 1 |
| Cantarella, F | 1 |
| Vanini, P | 1 |
| Tomasicchio, G | 1 |
| Altomare, DF | 4 |
| Rinaldi, M | 2 |
| Santoro, GA | 1 |
| Currò, G | 1 |
| Grossi, U | 1 |
| Damin, DC | 1 |
| Contu, PC | 1 |
| Emile, SH | 2 |
| Abdel-Razik, MA | 1 |
| Elshobaky, A | 1 |
| Elbaz, SA | 1 |
| Khafagy, W | 3 |
| Shalaby, M | 1 |
| Williams, T | 1 |
| Rudge, E | 1 |
| Wakefield, S | 1 |
| Acar, T | 1 |
| Acar, N | 1 |
| Güngör, F | 1 |
| Kamer, E | 1 |
| Genç, H | 1 |
| Atahan, K | 1 |
| Dilek, ON | 1 |
| Hacıyanlı, M | 1 |
| Pérez-Pereda, S | 1 |
| González-Quintanilla, V | 1 |
| Madera, J | 1 |
| Pascual, J | 1 |
| Patkova, B | 1 |
| Wester, T | 1 |
| Yilmaz, G | 1 |
| Tanrikulu, Y | 1 |
| Joda, AE | 1 |
| Al-Mayoof, AF | 1 |
| Elgendy, H | 1 |
| Elfeki, H | 1 |
| Magdy, A | 1 |
| Abdelmawla, AA | 1 |
| Abdelnaby, M | 1 |
| Nelson, RL | 1 |
| Manuel, D | 1 |
| Gumienny, C | 1 |
| Spencer, B | 1 |
| Patel, K | 1 |
| Schmitt, K | 1 |
| Castillo, D | 1 |
| Bravo, A | 1 |
| Yeboah-Sampong, A | 1 |
| Newman, M | 1 |
| Collie, M | 1 |
| Ala, S | 1 |
| Saeedi, M | 1 |
| Hadianamrei, R | 1 |
| Ghorbanian, A | 1 |
| Berry, SM | 1 |
| Barish, CF | 1 |
| Bhandari, R | 1 |
| Clark, G | 1 |
| Collins, GV | 1 |
| Howell, J | 1 |
| Pappas, JE | 1 |
| Riff, DS | 2 |
| Safdi, M | 1 |
| Yellowlees, A | 1 |
| Peng, H | 1 |
| Wang, JP | 1 |
| Yang, XQ | 1 |
| Zheng, Y | 1 |
| Ding, YJ | 1 |
| Ding, SQ | 1 |
| Li, GD | 1 |
| Jing, JZ | 1 |
| Zhao, BM | 1 |
| Zhang, SX | 1 |
| Chen, CW | 1 |
| Zhan, XB | 1 |
| Yao, LQ | 1 |
| Chen, WF | 1 |
| Zheng, QS | 1 |
| Huang, JH | 1 |
| Aslam, MI | 1 |
| Pervaiz, A | 1 |
| Figueiredo, R | 1 |
| Centkowska, K | 1 |
| Sznitowska, M | 1 |
| Shawki, S | 1 |
| Costedio, M | 1 |
| Asim, M | 1 |
| Lowrie, N | 1 |
| Stewart, J | 1 |
| Lolohea, S | 1 |
| Van Dalen, R | 1 |
| Brillantino, A | 1 |
| Iacobellis, F | 1 |
| Izzo, G | 1 |
| Di Martino, N | 1 |
| Grassi, R | 1 |
| Renzi, A | 1 |
| Pardhan, A | 1 |
| Azami, R | 1 |
| Mazahir, S | 1 |
| Murtaza, G | 1 |
| Vershenya, S | 1 |
| Klotz, J | 1 |
| Joos, A | 1 |
| Bussen, D | 1 |
| Herold, A | 4 |
| Motie, MR | 1 |
| Hashemi, P | 1 |
| Medhi, B | 1 |
| Rao, RS | 1 |
| Prakash, A | 1 |
| Prakash, O | 1 |
| Kaman, L | 1 |
| Pandhi, P | 1 |
| Singh, JC | 1 |
| Davies, M | 1 |
| Khot, U | 1 |
| Chandrasekaran, TV | 1 |
| Carr, ND | 1 |
| Beynon, J | 1 |
| Siddique, MI | 1 |
| Murshed, KM | 1 |
| Majid, MA | 1 |
| Wray, D | 1 |
| Ijaz, S | 1 |
| Lidder, S | 1 |
| Takáts, K | 1 |
| Tóth, A | 1 |
| Bursics, A | 1 |
| Tankova, L | 1 |
| Yoncheva, K | 1 |
| Kovatchki, D | 1 |
| Doytchinova, I | 1 |
| Schiano di Visconte, M | 2 |
| Munegato, G | 2 |
| Irkorucu, O | 1 |
| Ucan, HB | 1 |
| Comert, M | 1 |
| Farid, M | 1 |
| El Nakeeb, A | 1 |
| Youssef, M | 1 |
| Omar, W | 1 |
| Fouda, E | 1 |
| Youssef, T | 1 |
| Thabet, W | 1 |
| Elmoneum, HA | 1 |
| Corno, F | 1 |
| Marano, A | 1 |
| Volpatto, S | 1 |
| Mistrangelo, P | 1 |
| Jawaid, M | 1 |
| Masood, Z | 1 |
| Salim, M | 1 |
| Hashmi, F | 1 |
| Siddiqui, FG | 1 |
| Herzig, DO | 1 |
| Lu, KC | 1 |
| Abd Elhady, HM | 1 |
| Othman, IH | 1 |
| Hablus, MA | 1 |
| Ismail, TA | 1 |
| Aboryia, MH | 1 |
| Selim, MF | 1 |
| Rather, SA | 1 |
| Dar, TI | 1 |
| Malik, AA | 1 |
| Rather, AA | 1 |
| Khan, A | 1 |
| Parray, FQ | 1 |
| Wani, RA | 1 |
| Sileri, P | 2 |
| Stolfi, VM | 2 |
| Franceschilli, L | 1 |
| Grande, M | 2 |
| Di Giorgio, A | 1 |
| D'Ugo, S | 1 |
| Attina', G | 1 |
| D'Eletto, M | 1 |
| Gaspari, AL | 2 |
| Gagliardi, G | 1 |
| Pascariello, A | 1 |
| Arcanà, F | 2 |
| Cafaro, D | 1 |
| La Torre, F | 1 |
| De Nardi, P | 2 |
| Basso, L | 1 |
| De Stefano, I | 1 |
| Greco, VJ | 1 |
| Vasapollo, L | 1 |
| Amato, A | 1 |
| Pulvirenti D'Urso, A | 1 |
| Aiello, D | 1 |
| Bove, A | 1 |
| Karamanlis, E | 1 |
| Michalopoulos, A | 1 |
| Papadopoulos, V | 1 |
| Mekras, A | 1 |
| Panagiotou, D | 1 |
| Ioannidis, A | 1 |
| Basdanis, G | 1 |
| Fahantidis, E | 1 |
| Binda, GA | 1 |
| Canuti, S | 1 |
| Landolfi, V | 1 |
| Villani, RD | 1 |
| Nelson, R | 4 |
| Sinha, R | 1 |
| Kaiser, AM | 2 |
| Perez-Legaz, J | 2 |
| Arroyo, A | 2 |
| Lopez-Delgado, A | 1 |
| Frangi, A | 2 |
| Moya, P | 2 |
| Santos, J | 1 |
| Candela, F | 2 |
| Calpena, R | 2 |
| Cevik, M | 1 |
| Boleken, ME | 1 |
| Koruk, I | 1 |
| Ocal, S | 1 |
| Balcioglu, ME | 1 |
| Aydinoglu, A | 1 |
| Karadag, CA | 1 |
| Krammer, H | 1 |
| Sajid, MS | 3 |
| Whitehouse, PA | 1 |
| Sains, P | 1 |
| Baig, MK | 3 |
| Oliver, MI | 1 |
| Acheson, AG | 3 |
| Griffin, N | 1 |
| Scholefield, JH | 12 |
| Briel, JW | 1 |
| Zimmerman, DD | 1 |
| Schouten, WR | 3 |
| Sönmez, K | 1 |
| Demiroğullari, B | 1 |
| Ekingen, G | 1 |
| Türkyilmaz, Z | 1 |
| Karabulut, R | 1 |
| Başaklar, AC | 1 |
| Kale, N | 1 |
| Jonas, M | 7 |
| Speake, W | 1 |
| Svendsen, CB | 1 |
| Matzen, P | 1 |
| Scholefield, J | 5 |
| Balaji, NS | 1 |
| Ahmad, M | 1 |
| Bailey, HR | 1 |
| Beck, DE | 1 |
| Billingham, RP | 1 |
| Binderow, SR | 1 |
| Gottesman, L | 1 |
| Hull, TL | 1 |
| Larach, SW | 1 |
| Margolin, DA | 1 |
| Milsom, JW | 1 |
| Potenti, FM | 1 |
| Rafferty, JF | 1 |
| Sands, LR | 2 |
| Senagore, A | 1 |
| Stamos, MJ | 1 |
| Yee, LF | 1 |
| Young-Fadok, TM | 1 |
| Gibbons, RD | 1 |
| Libertiny, G | 1 |
| Knight, JS | 1 |
| Farouk, R | 2 |
| Garner, JP | 1 |
| McFall, M | 1 |
| Edwards, DP | 2 |
| Stein, E | 1 |
| Bock, JU | 1 |
| Marla, B | 1 |
| Richter, HJ | 1 |
| Athanasiadis, S | 1 |
| Pröls, M | 1 |
| Lindsey, I | 4 |
| Jones, OM | 4 |
| Cunningham, C | 3 |
| George, BD | 2 |
| Mortensen, NJ | 3 |
| Aitola, P | 1 |
| Hiltunen, KM | 1 |
| Bielecki, K | 1 |
| Kolodziejczak, M | 1 |
| Porrett, T | 1 |
| Knowles, CH | 1 |
| Lunniss, PJ | 1 |
| Utzig, MJ | 1 |
| Kroesen, AJ | 1 |
| Buhr, HJ | 1 |
| Simpson, J | 1 |
| Lund, JN | 10 |
| Thompson, RJ | 1 |
| Kapila, L | 1 |
| Madalinski, M | 2 |
| Novell, F | 1 |
| Novell-Costa, F | 1 |
| Novell, J | 1 |
| Colak, T | 1 |
| Ipek, T | 1 |
| Urkaya, N | 1 |
| Kanik, A | 1 |
| Dirlik, M | 1 |
| Slim, K | 1 |
| Siproudhis, L | 1 |
| Boschetto, S | 1 |
| Giovannone, M | 1 |
| Tosoni, M | 1 |
| Barberani, F | 1 |
| Weinstein, D | 1 |
| Halevy, A | 1 |
| Negri, M | 1 |
| Levy, N | 1 |
| Gelertner, I | 1 |
| Ziv, Y | 1 |
| Orsay, C | 1 |
| Rakinic, J | 1 |
| Perry, WB | 1 |
| Hyman, N | 1 |
| Buie, D | 2 |
| Cataldo, P | 1 |
| Newstead, G | 1 |
| Dunn, G | 1 |
| Rafferty, J | 1 |
| Ellis, CN | 1 |
| Shellito, P | 1 |
| Gregorcyk, S | 1 |
| Ternent, C | 1 |
| Kilkenny, J | 1 |
| Tjandra, J | 1 |
| Ko, C | 1 |
| Whiteford, M | 1 |
| Haq, Z | 1 |
| Rahman, M | 1 |
| Chowdhury, RA | 1 |
| Baten, MA | 1 |
| Khatun, M | 1 |
| Thornton, MJ | 1 |
| Kennedy, ML | 2 |
| King, DW | 1 |
| Demirbag, S | 2 |
| Tander, B | 2 |
| Atabek, C | 1 |
| Surer, I | 1 |
| Oztürk, H | 2 |
| Cetinkursun, S | 2 |
| Madoff, RD | 1 |
| Mishra, R | 1 |
| Thomas, S | 1 |
| Maan, MS | 1 |
| Hadke, NS | 1 |
| Ortolano, E | 1 |
| Radaelli, G | 1 |
| Staudacher, C | 1 |
| Tranqui, P | 1 |
| Trottier, DC | 1 |
| Victor, C | 1 |
| Freeman, JB | 1 |
| Fenton, C | 1 |
| Wellington, K | 1 |
| Easthope, SE | 1 |
| Torrabadella, L | 1 |
| Salgado, G | 2 |
| MacLean, A | 1 |
| Fruehauf, H | 1 |
| Fried, M | 1 |
| Wegmueller, B | 1 |
| Bauerfeind, P | 1 |
| Thumshirn, M | 1 |
| Nyström, PO | 1 |
| Coremans, G | 1 |
| Karaitianos, I | 1 |
| Spyrou, M | 1 |
| Sebastian, AA | 1 |
| Pescatori, M | 2 |
| Ramalingam, T | 1 |
| Merrie, A | 1 |
| Di Bella, R | 1 |
| Hashmat, A | 1 |
| Ishfaq, T | 1 |
| Pascual, M | 2 |
| Pera, M | 2 |
| Courtier, R | 2 |
| Gil, MJ | 2 |
| Parés, D | 2 |
| Puig, S | 2 |
| Andreu, M | 2 |
| Grande, L | 2 |
| Brisinda, G | 3 |
| Cadeddu, F | 1 |
| Brandara, F | 1 |
| Marniga, G | 1 |
| Maria, G | 3 |
| Brown, CJ | 1 |
| Dubreuil, D | 1 |
| Santoro, L | 1 |
| Liu, M | 1 |
| O'Connor, BI | 2 |
| McLeod, RS | 2 |
| Kelly, T | 1 |
| Ballal, M | 1 |
| Khera, G | 1 |
| Serrano, A | 1 |
| Shrivastava, UK | 1 |
| Jain, BK | 1 |
| Kumar, P | 1 |
| Saifee, Y | 1 |
| Dhawan, S | 1 |
| Chopra, S | 1 |
| Nash, G | 1 |
| Bhardwaj, R | 1 |
| Parker, MC | 1 |
| Mele, A | 1 |
| Sica, G | 1 |
| Gentileschi, P | 1 |
| Di Carlo, S | 1 |
| Rimple, J | 1 |
| Cheek, E | 2 |
| Vijaynagar, B | 1 |
| Desai, M | 1 |
| Ahmad, J | 1 |
| Andrabi, SI | 1 |
| Rathore, MA | 1 |
| Duh, D | 1 |
| Vandevijver, A | 1 |
| Heitland, W | 1 |
| Lubowski, D | 1 |
| Emami, MH | 1 |
| Sayedyahossein, S | 1 |
| Aslani, A | 1 |
| Gorfine, SR | 2 |
| Watson, SJ | 1 |
| Kamm, MA | 2 |
| Nicholls, RJ | 1 |
| Phillips, RK | 2 |
| Armitage, NC | 1 |
| Simons, AJ | 1 |
| Beart, RW | 1 |
| Larpent, JL | 1 |
| Dussaud, F | 1 |
| Gorce, D | 1 |
| Lunaud, B | 1 |
| Pelissier, E | 1 |
| Chisholm, EM | 1 |
| Herxheimer, A | 1 |
| Miser, WF | 1 |
| Banerjee, AK | 1 |
| Bacher, H | 1 |
| Mischinger, HJ | 1 |
| Werkgartner, G | 1 |
| Cerwenka, H | 1 |
| El-Shabrawi, A | 1 |
| Pfeifer, J | 1 |
| Schweiger, W | 1 |
| Oettlé, GJ | 1 |
| Tarnoff, M | 1 |
| Goodman, M | 1 |
| Cataldo, T | 1 |
| Atabek, U | 1 |
| Alexander, JB | 1 |
| Koniges, F | 1 |
| Costabile, J | 1 |
| Pello, M | 1 |
| Benkwitz, C | 1 |
| Koch, TR | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Application of Vitamin E Acetate Ointment vs Nitroglycerin Ointment for the Treatment of Chronic Anal Fissure[NCT03787030] | Phase 3 | 160 participants (Actual) | Interventional | 2018-12-21 | Completed | ||
| Topical 5% Minoxidil Versus 0.2%Topical Glyceryl Trinitrate in Treatment of Chronic Anal Fissure: a Randomized Controlled Trial[NCT03528772] | 62 participants (Actual) | Interventional | 2018-05-10 | Completed | |||
| Assessing and Comparing the Effect of Diltiazem Gel Versus Nitroglycerin Ointment in Healing Process of Scleroderma Digital Ulcers.[NCT02801305] | Phase 2 | 90 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| Randomized Controlled Trial Comparing the Efficacy of Polyethylene Glycol Alone and Polyethylene Glycol Combined With Topical Diltiazem in Treating Anal fissure in Children[NCT02419534] | Phase 4 | 46 participants (Anticipated) | Interventional | 2014-11-30 | Recruiting | ||
| A Randomized. Double-blind, Placebo-controlled, Multi-national Study to Determine the Effect of Cellegesic Nitroglycerin Ointment 0.4% (Cellegesic) on the Pain Associated With a Chronic Anal Fissure[NCT00522041] | Phase 3 | 248 participants (Actual) | Interventional | 2007-08-31 | Completed | ||
| Effects of Platelet-rich Plasma in the Treatment of Chronic Anal Fissure[NCT04320498] | Phase 4 | 41 participants (Actual) | Interventional | 2019-01-01 | Completed | ||
| Comparative Evaluation of MEBO Ointment and Topical Diltiazem Ointment in the Treatment of Acute Anal Fissure: a Randomized Clinical Trial[NCT04153032] | Phase 2 | 183 participants (Anticipated) | Interventional | 2019-12-01 | Recruiting | ||
| Perianal vs Endoanal Application of Glyceryl Trinitrate 0.4% Ointment in the Treatment of Chronic Anal Fissure: Results of a Randomized Controlled Trial.[NCT01132391] | Phase 3 | 60 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| Idiopathic Hypertensive Anal Canal: a Place of Internal Sphincterotomy[NCT00927849] | 63 participants (Actual) | Interventional | 2002-09-30 | Completed | |||
| A Phase 4, Multiple-dose, Pharmacokinetic, Safety, and Exploratory Efficacy Study of Nitroglycerin Ointment 0.4% (RECTIV®) in Adolescents (Age ≥12 to <17 Years) With Moderate to Severe Pain Due to Chronic Anal Fissure[NCT01920074] | Phase 4 | 0 participants (Actual) | Interventional | 2013-06-30 | Withdrawn (stopped due to Study stopped due to study enrollment challenges that impacted the feasibility of conducting the study.) | ||
| Effect of Nitroglycerin Ointment on Mastectomy Flap Necrosis[NCT01608880] | 154 participants (Actual) | Interventional | 2012-08-31 | Completed | |||
| Botulin Toxin Versus Isosorbidedinitrate Ointment in Treatment Anal Fissure; A Prospective, Blinded, Randomized Trial[NCT00827736] | Phase 4 | 73 participants (Actual) | Interventional | 2002-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale at Baseline and on Days 14 through 18. The average pain rating on Days 14 through 18 was calculated and used to determine the change from Baseline. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. A negative change score indicated improvement." (NCT00522041)
Timeframe: Baseline to Day 18
| Intervention | Units on a scale (Mean) |
|---|---|
| Cellegesic (Nitroglycerin 0.4%) | -40.4 |
| Placebo | -34.9 |
"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale at Baseline and on Days 14 through 18. The average pain rating on Days 14 through 18 was calculated. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. A responder was defined as a participant with either a ≥ 50% decrease or a ≥ 10 mm decrease from Baseline in the 24 hour average pain intensity averaged over Days 14 to 18." (NCT00522041)
Timeframe: Baseline to Day 18
| Intervention | Percentage of responders (Number) | |
|---|---|---|
| ≥ 50% decrease | ≥ 10 mm decrease | |
| Cellegisic (Nitroglycerin 0.4%) | 72.4 | 88.6 |
| Placebo | 64.5 | 85.5 |
"Participants rated the pain associated with their chronic anal fissure over the preceding 24 hours on a 100 mm visual analog scale (VAS) at Baseline and on each of the 21 treatment days of the study. The left-end of the visual analog scale was labelled least possible pain and the right-end of the visual analog scale was labelled worst possible pain. The pain rating ranged from 0 to 100, with a higher score indicating more pain. Improvement was defined as either a ≥ 50% decrease or a ≥ 10 mm decrease from Baseline in rated pain intensity." (NCT00522041)
Timeframe: Baseline to Day 21
| Intervention | Days (Mean) | |
|---|---|---|
| ≥ 50% decrease | ≥ 10 mm decrease | |
| Cellegisic (Nitroglycerin 0.4%) | 10.7 | 6.1 |
| Placebo | 13.2 | 7.2 |
using a visual analog scale (VAS) with which each patients noted the severity of pain at each evaluated time using a linear between zero (no pain) and 10 ( severe pain) (NCT00927849)
Timeframe: one year after the procedure
| Intervention | score in scale (Mean) |
|---|---|
| Surgical Group Lateral Sphincterotomy | 4.16 |
| Glycein Trinitrate Group | 4.18 |
| Botilinium Toxin Injection | 4.2 |
44 reviews available for nitroglycerin and Anal Fissure
| Article | Year |
|---|---|
A systematic review and meta-analysis of the efficacy of topical sphincterotomy treatments for anal fissure.
Topics: Administration, Topical; Chronic Disease; Diltiazem; Fissure in Ano; Humans; Nitroglycerin; Sphincte | 2022 |
Clinical Outcomes of Medical Management Options for Chronic Anal Fissures in a Long-Term Follow-up: Systematic Review and Meta-Analysis.
Topics: Adult; Chronic Disease; Fissure in Ano; Glycerol; Humans; Nifedipine; Nitroglycerin; Treatment Outco | 2023 |
Anal Fissure in Children.
Topics: Botulinum Toxins; Calcium Channel Blockers; Child; Conservative Treatment; Constipation; Fissure in | 2020 |
A systematic review and meta-analysis of the treatment of anal fissure.
Topics: Anal Canal; Calcium Channel Blockers; Fecal Incontinence; Fissure in Ano; Humans; Nitroglycerin; Ran | 2017 |
Anal fissure and stenosis.
Topics: Anal Canal; Anus Diseases; Botulinum Toxins, Type A; Calcium Channel Blockers; Constriction, Patholo | 2013 |
Recent advances in the pharmacotherapy of chronic anal fissure: an update.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel | 2008 |
Recent advances in the pharmacotherapy of chronic anal fissure: an update.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel | 2008 |
Recent advances in the pharmacotherapy of chronic anal fissure: an update.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel | 2008 |
Recent advances in the pharmacotherapy of chronic anal fissure: an update.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel | 2008 |
Anal fissure: a review.
Topics: Anal Canal; Botulinum Toxins; Calcium Channel Blockers; Dilatation; Fissure in Ano; Humans; Isosorbi | 2008 |
Anal fissure.
Topics: Acute Disease; Anal Canal; Botulinum Toxins, Type A; Calcium Channel Blockers; Chronic Disease; Dilt | 2010 |
The management of patients with primary chronic anal fissure: a position paper.
Topics: Anal Canal; Botulinum Toxins; Calcium Channel Blockers; Chronic Disease; Fissure in Ano; Humans; Nit | 2011 |
Anal fissure (chronic).
Topics: Administration, Oral; Anal Canal; Fissure in Ano; Humans; Nitric Oxide Donors; Nitroglycerin; Treatm | 2010 |
Systematic review of the use of topical diltiazem compared with glyceryltrinitrate for the nonoperative management of chronic anal fissure.
Topics: Administration, Topical; Chronic Disease; Diltiazem; Fissure in Ano; Headache; Humans; Nitroglycerin | 2013 |
[Treatment of chronic anal fissure with topically applied nitroglycerin ointment. A systematic review of evidence-based results].
Topics: Administration, Topical; Anal Canal; Chronic Disease; Evidence-Based Medicine; Fissure in Ano; Heada | 2002 |
Anal fissure.
Topics: Administration, Topical; Anal Canal; Botulinum Toxins, Type A; Drug Combinations; Fissure in Ano; He | 2002 |
A study to determine the nitroglycerin ointment dose and dosing interval that best promote the healing of chronic anal fissures.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Double-Blind Method; Drug Administration Schedule; | 2002 |
The medical and surgical management of chronic anal fissure.
Topics: Adrenergic alpha-Antagonists; Botulinum Toxins, Type A; Calcium Channel Blockers; Chronic Disease; F | 2002 |
Botulinum toxin and anal fissure.
Topics: Administration, Topical; Botulinum Toxins, Type A; Fissure in Ano; Humans; Nitroglycerin | 2002 |
Anal fissure.
Topics: Administration, Topical; Anal Canal; Botulinum Toxins, Type A; Drug Combinations; Fissure in Ano; He | 2002 |
[Treatment of anal fissure].
Topics: Anal Canal; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Fissure in Ano; Humans; N | 2003 |
Concepts in pathogenesis and treatment of chronic anal fissure--a review of the literature.
Topics: Administration, Topical; Anti-Dyskinesia Agents; Botulinum Toxins; Calcium Channel Blockers; Chronic | 2003 |
Anal fissure.
Topics: Anal Canal; Botulinum Toxins, Type A; Female; Fissure in Ano; Humans; Male; Nitroglycerin; Surgical | 2003 |
Anal fissure: the changing management of a surgical condition.
Topics: Algorithms; Anal Canal; Botulinum Toxins; Calcium Channel Blockers; Fissure in Ano; Humans; Nitrogly | 2005 |
Chronic anal fissure.
Topics: Anal Canal; Botulinum Toxins, Type A; Calcium Channel Blockers; Diltiazem; Fecal Incontinence; Fissu | 2004 |
A systematic review of medical therapy for anal fissure.
Topics: Adult; Botulinum Toxins, Type A; Child; Fissure in Ano; Humans; Neuromuscular Agents; Nifedipine; Ni | 2004 |
[Anal fissure. Which first line treatment?].
Topics: Botulinum Toxins, Type A; Dilatation; Diltiazem; Evidence-Based Medicine; Fecal Incontinence; Fissur | 2004 |
Anal fissure.
Topics: Anal Canal; Botulinum Toxins, Type A; Diltiazem; Female; Fissure in Ano; Humans; Male; Nitroglycerin | 2004 |
Chemical sphincterotomy--first line of treatment for chronic anal fissure.
Topics: Botulinum Toxins; Calcium Channel Blockers; Chronic Disease; Diltiazem; Fissure in Ano; Humans; Isos | 2005 |
Anal fissure (chronic).
Topics: Anal Canal; Botulinum Toxins, Type A; Diltiazem; Female; Fissure in Ano; Humans; Male; Nitroglycerin | 2004 |
Pharmacological advancements in the treatment of chronic anal fissure.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Albuterol; Botulinu | 2005 |
0.4% nitroglycerin ointment : in the treatment of chronic anal fissure pain.
Topics: Administration, Topical; Chronic Disease; Drug Administration Schedule; Fissure in Ano; Humans; Nitr | 2006 |
Nonsurgical approaches for the treatment of anal fissures.
Topics: Anal Canal; Botulinum Toxins; Chronic Disease; Diltiazem; Fissure in Ano; Humans; Muscle Relaxation; | 2007 |
Modern perspectives in the treatment of chronic anal fissures.
Topics: Botulinum Toxins; Chronic Disease; Diltiazem; Fissure in Ano; Humans; Nitric Oxide Donors; Nitroglyc | 2007 |
The efficacy of diltiazem and glyceryltrinitrate for the medical management of chronic anal fissure: a meta-analysis.
Topics: Chronic Disease; Diltiazem; Fissure in Ano; Headache; Humans; Nitroglycerin; Prospective Studies; Ra | 2008 |
Botulinum toxin vs glyceryltrinitrate for the medical management of chronic anal fissure: a meta-analysis.
Topics: Anti-Dyskinesia Agents; Botulinum Toxins; Chronic Disease; Female; Fissure in Ano; Humans; Male; Nit | 2008 |
[Fistulas and fissures. Part II: fissures].
Topics: Administration, Topical; Anal Canal; Botulinum Toxins, Type A; Calcium Channel Blockers; Evidence-Ba | 2008 |
A nonsurgical approach to chronic anal fissure.
Topics: Administration, Topical; Chronic Disease; Fissure in Ano; Humans; Nitroglycerin; Pain; Risk Factors; | 1997 |
[Local treatment of anal fissure with nitroglycerin ointment].
Topics: Administration, Topical; Fissure in Ano; Humans; Nitric Oxide; Nitroglycerin; Ointments; Vasodilator | 1998 |
Glyceryl trinitrate for anal fissure?
Topics: Clinical Trials as Topic; Fissure in Ano; Humans; Nitroglycerin; Ointments; Vasodilator Agents | 1998 |
[The treatment of chronic fissure in ano with nitrate ointment].
Topics: Administration, Topical; Female; Fissure in Ano; Humans; Isosorbide Dinitrate; Male; Nitroglycerin; | 1999 |
Fissure-in-ano, to divide or not to divide?
Topics: Algorithms; Anti-Dyskinesia Agents; Botulinum Toxins; Chronic Disease; Fissure in Ano; Humans; Nitro | 1999 |
Cut or paste? The use of glyceryl trinitrate paste in the treatment of acute and chronic anal fissure.
Topics: Acute Disease; Chronic Disease; Combined Modality Therapy; Fissure in Ano; Humans; Nitroglycerin; Oi | 2000 |
Anal fissures.
Topics: Chronic Disease; Constipation; Dietary Fiber; Digestive System Surgical Procedures; Fissure in Ano; | 2000 |
Treatment of anal fissures with topical nitroglycerin.
Topics: Administration, Topical; Double-Blind Method; Female; Fissure in Ano; Humans; Male; Nitroglycerin; O | 2001 |
Progress in the understanding and treatment of chronic anal fissure.
Topics: Administration, Topical; Anal Canal; Botulinum Toxins; Calcium Channel Blockers; Chronic Disease; Di | 2001 |
[Nitric oxide donors and their potentiating effects after botulinum toxin application for treatment of chronic anal fissure].
Topics: Administration, Topical; Botulinum Toxins; Chronic Disease; Drug Synergism; Fissure in Ano; Humans; | 2002 |
76 trials available for nitroglycerin and Anal Fissure
| Article | Year |
|---|---|
Perianal Application of Glyceryl Trinitrate Ointment Versus Tocopherol Acetate Ointment in the Treatment of Chronic Anal Fissure: A Randomized Clinical Trial.
Topics: Administration, Topical; alpha-Tocopherol; Analgesics; Antioxidants; Female; Fissure in Ano; Humans; | 2022 |
Clinical Outcome of 0.2% Glyceryl Trinitrate Topical Ointment Compared to Lateral Internal Sphincterotomy in the Treatment of Patient with Chronic Anal Fissure: A Randomized Control Trial.
Topics: Administration, Topical; Adult; Anal Canal; Chronic Disease; Female; Fissure in Ano; Humans; Lateral | 2022 |
Efficacy and safety of Propionibacterium extract gel versus glyceryl trinitrate ointment in the treatment of chronic anal fissure: a randomized controlled trial.
Topics: Administration, Topical; Chronic Disease; Fissure in Ano; Humans; Nitroglycerin; Ointments; Propioni | 2023 |
Topical 5% minoxidil versus topical 0.2% glyceryl trinitrate in treatment of chronic anal fissure: A randomized clinical trial.
Topics: Administration, Topical; Adult; Chronic Disease; Female; Fissure in Ano; Humans; Male; Middle Aged; | 2020 |
Comparative efficacy of medical treatment versus surgical sphincterotomy in the treatment of chronic anal fissure.
Topics: Chronic Disease; Diltiazem; Fissure in Ano; Humans; Nitroglycerin; Pain Management; Quality of Life; | 2020 |
Short-term Results of Platelet-Rich Plasma in the Treatment of Chronic Anal Fissure: Randomized Controlled Clinical Study.
Topics: Acetylcholine Release Inhibitors; Adult; Botulinum Toxins; Case-Control Studies; Chronic Disease; Fe | 2021 |
Efficacy of nitroglycerine ointment in the treatment of pediatric anal fissure.
Topics: Administration, Rectal; Administration, Topical; Adolescent; Anal Canal; Anesthesia, Local; Anesthet | 2017 |
Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double-blind trial.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Diltiazem; Dou | 2012 |
Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double-blind trial.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Diltiazem; Dou | 2012 |
Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double-blind trial.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Diltiazem; Dou | 2012 |
Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double-blind trial.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Diltiazem; Dou | 2012 |
Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Double-Blind Method; Female; Fissu | 2013 |
[A multi-center, randomized, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in the treatment of anal fissure].
Topics: Adult; Double-Blind Method; Female; Fissure in Ano; Humans; Male; Middle Aged; Nitroglycerin; Treatm | 2013 |
Internal sphincterotomy versus topical nitroglycerin ointment for chronic anal fissure.
Topics: Administration, Topical; Anal Canal; Chronic Disease; Female; Fissure in Ano; Humans; Male; Nitrogly | 2014 |
Botulinum toxin versus botulinum toxin with low-dose glyceryltrinitrate for healing of chronic anal fissure: a prospective, randomised trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Dyskinesia Agents; Botulinum Toxins; Chronic Diseas | 2014 |
Maintenance therapy with partially hydrolyzed guar gum in the conservative treatment of chronic anal fissure: results of a prospective, randomized study.
Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Aged; Chronic Disease; Dietary Sup | 2014 |
Diltiazem vs. glyceryl tri-nitrate for symptomatic relief in anal fissure: a randomised clnical study.
Topics: Adult; Diltiazem; Female; Fissure in Ano; Humans; Male; Middle Aged; Nitroglycerin; Vasodilator Agen | 2014 |
Chronic Anal Fissure: A Comparative Study of Medical Treatment Versus Surgical Sphincterotomy.
Topics: Administration, Topical; Adult; Aged; Anal Canal; Chronic Disease; Digestive System Surgical Procedu | 2016 |
Percutaneous Posterior Tibial Nerve Stimulation vs Perianal Application of Glyceryl Trinitrate Ointment in the Treatment of Chronic Anal Fissure: A Randomized Clinical Trial.
Topics: Administration, Topical; Adult; Chronic Disease; Electric Stimulation Therapy; Female; Fissure in An | 2017 |
Comparative study of lateral internal sphincterotomy versus local 0.2% glyceryl trinitrate ointment for the treatment of chronic anal fissure.
Topics: Adolescent; Adult; Chronic Disease; Digestive System Surgical Procedures; Female; Fissure in Ano; Hu | 2008 |
Topical anal fissure treatment: placebo-controlled study of mononitrate and trinitrate therapies.
Topics: Administration, Topical; Adolescent; Adult; Aged; Female; Fissure in Ano; Humans; Isosorbide Dinitra | 2009 |
Glyceryl trinitrate ointment (0.25%) and anal cryothermal dilators in the treatment of chronic anal fissures.
Topics: Administration, Topical; Adolescent; Adult; Anal Canal; Chronic Disease; Cryotherapy; Dilatation; Fe | 2009 |
Idiopathic hypertensive anal canal: a place of internal sphincterotomy.
Topics: Administration, Rectal; Adolescent; Adult; Analysis of Variance; Botulinum Toxins; Female; Fissure i | 2009 |
[Topical use of glyceryl-trinitrate in the treatment of anal fissure].
Topics: Administration, Cutaneous; Anal Canal; Female; Fissure in Ano; Humans; Male; Medication Adherence; M | 2009 |
Topical diltiazem hydrochloride and glyceryl trinitrate in the treatment of chronic anal fissure.
Topics: Calcium Channel Blockers; Chronic Disease; Diltiazem; Female; Fissure in Ano; Humans; Male; Nitrogly | 2009 |
Long-term prospective randomised clinical and manometric comparison between surgical and chemical sphincterotomy for treatment of chronic anal fissure.
Topics: Adolescent; Adult; Aged; Anal Canal; Botulinum Toxins; Calcium Channel Blockers; Chronic Disease; Di | 2009 |
Optimal treatment duration of glyceryl trinitrate for chronic anal fissure: results of a prospective randomized multicenter trial.
Topics: Administration, Topical; Adult; Analysis of Variance; Chronic Disease; Dose-Response Relationship, D | 2010 |
Prospective clinical trial comparing sphincterotomy, nitroglycerin ointment and xylocaine/lactulose combination for the treatment of anal fissure.
Topics: Administration, Oral; Administration, Topical; Adult; Aged; Anal Canal; Combined Modality Therapy; D | 2010 |
A prospective, randomized, double-blind study comparing the efficacy of diltiazem, glyceryl trinitrate, and lidocaine for the treatment of anal fissure in children.
Topics: Anesthetics, Local; Child; Child, Preschool; Diltiazem; Double-Blind Method; Female; Fissure in Ano; | 2012 |
Perianal versus endoanal application of glyceryl trinitrate 0.4% ointment in the treatment of chronic anal fissure: results of a randomized controlled trial. Is this the solution to the headaches?
Topics: Adolescent; Adult; Aged; Chronic Disease; Drug Administration Schedule; Female; Fissure in Ano; Foll | 2012 |
Randomized, placebo-controlled treatment of anal fissure by lidocaine, EMLA, and GTN in children.
Topics: Administration, Topical; Adolescent; Anesthetics, Local; Child; Child, Preschool; Female; Fissure in | 2002 |
A study to determine the nitroglycerin ointment dose and dosing interval that best promote the healing of chronic anal fissures.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Double-Blind Method; Drug Administration Schedule; | 2002 |
Randomised trial of topical 0.2% glyceryl trinitrate and lateral internal sphincterotomy for the treatment of patients with chronic anal fissure: long-term follow-up.
Topics: Administration, Topical; Adolescent; Adult; Chronic Disease; Confidence Intervals; Female; Fissure i | 2002 |
A dose finding study with 0.1%, 0.2%, and 0.4% glyceryl trinitrate ointment in patients with chronic anal fissures.
Topics: Adult; Anal Canal; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Method; Female; F | 2003 |
Botulinum toxin as second-line therapy for chronic anal fissure failing 0.2 percent glyceryl trinitrate.
Topics: Adult; Aged; Aged, 80 and over; Anal Canal; Botulinum Toxins; Chronic Disease; Female; Fissure in An | 2003 |
A prospective randomized trial of diltiazem and glyceryltrinitrate ointment in the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Aged; Chronic Disease; Diltiazem; Female; Fissure in Ano; Humans; Ma | 2003 |
The use of glyceryl trinitrate (GTN) in the treatment of chronic anal fissure in children.
Topics: Adolescent; Child; Child, Preschool; Chronic Disease; Female; Fissure in Ano; Humans; Male; Nitrogly | 2003 |
Topical glyceryl trinitrate in the treatment of anal fissure.
Topics: Administration, Topical; Adult; Aged; Female; Fissure in Ano; Humans; Male; Middle Aged; Nitroglycer | 2004 |
A randomised study comparing systemic transdermal treatment and local application of glyceryl trinitrate ointment in the management of chronic anal fissure.
Topics: Administration, Cutaneous; Administration, Topical; Adult; Chronic Disease; Female; Fissure in Ano; | 2003 |
Hydropneumatic anal dilation in conservative treatment of chronic anal fissure: clinical outcomes and randomized comparison with topical nitroglycerin.
Topics: Administration, Topical; Catheterization; Chronic Disease; Feasibility Studies; Female; Fissure in A | 2004 |
[A prospective, randomized double-blind study on the treatment of anal fissures with Nitroglycerin ointment].
Topics: Double-Blind Method; Fissure in Ano; Humans; Nitroglycerin; Ointments; Pain; Pain Measurement; Place | 2004 |
Manometric effect of topical glyceryl trinitrate and its impact on chronic anal fissure healing.
Topics: Administration, Topical; Adult; Aged; Anal Canal; Chronic Disease; Drug Administration Schedule; Fem | 2005 |
Topical nitroglycerin versus lateral internal sphincterotomy for chronic anal fissure: prospective, randomized trial.
Topics: Adult; Aged; Anal Canal; Female; Fissure in Ano; Humans; Male; Middle Aged; Nitroglycerin; Prospecti | 2005 |
Comparison of glycerine trinitrate and botulinum toxin-a for the treatment of chronic anal fissure: long-term results.
Topics: Adult; Aged; Botulinum Toxins, Type A; Chronic Disease; Female; Fissure in Ano; Follow-Up Studies; H | 2006 |
Controlled dose delivery in topical treatment of anal fissure: pilot study of a new paradigm.
Topics: Administration, Rectal; Adult; Anal Canal; Catheterization; Drug Delivery Systems; Female; Fissure i | 2006 |
Efficacy and safety of botulinum toxin a injection compared with topical nitroglycerin ointment for the treatment of chronic anal fissure: a prospective randomized study.
Topics: Administration, Topical; Adult; Aged; Botulinum Toxins, Type A; Chronic Disease; Drug Therapy, Combi | 2006 |
Randomized clinical trial of botulinum toxin plus glyceryl trinitrate vs. botulinum toxin alone for medically resistant chronic anal fissure: overall poor healing rates.
Topics: Adult; Aged; Botulinum Toxins; Drug Therapy, Combination; Female; Fissure in Ano; Humans; Male; Midd | 2006 |
Randomized, prospective trial comparing 0.25 percent glycerin trinitrate ointment and anal cryothermal dilators only with 0.25 percent glycerin trinitrate ointment and only with anal cryothermal dilators in the treatment of chronic anal fissure: a two-yea
Topics: Adolescent; Adult; Chronic Disease; Cryotherapy; Dilatation; Female; Fissure in Ano; Follow-Up Studi | 2006 |
Endosonographic and manometric evaluation of internal anal sphincter in patients with chronic anal fissure and its correlation with clinical outcome after topical glyceryl trinitrate therapy.
Topics: Administration, Topical; Adult; Anal Canal; Chronic Disease; Endosonography; Female; Fissure in Ano; | 2007 |
Randomized clinical trial comparing botulinum toxin injections with 0.2 per cent nitroglycerin ointment for chronic anal fissure.
Topics: Administration, Topical; Adult; Botulinum Toxins, Type A; Chronic Disease; Female; Fissure in Ano; F | 2007 |
Lateral internal sphincterotomy is superior to topical nitroglycerin for healing chronic anal fissure and does not compromise long-term fecal continence: six-year follow-up of a multicenter, randomized, controlled trial.
Topics: Administration, Topical; Adult; Anal Canal; Chronic Disease; Female; Fissure in Ano; Follow-Up Studi | 2007 |
A comparison of the effects of diltiazem and glyceryl trinitrate ointment in the treatment of chronic anal fissure: a randomized clinical trial.
Topics: Administration, Topical; Adolescent; Adult; Chronic Disease; Diltiazem; Female; Fissure in Ano; Huma | 2007 |
Medical and surgical treatment of chronic anal fissure: a prospective study.
Topics: Adult; Botulinum Toxins; Chronic Disease; Dilatation; Female; Fissure in Ano; Humans; Male; Nitrogly | 2007 |
Comparison of topical glyceryl trinitrate with lignocaine ointment for treatment of anal fissure: a randomised controlled trial.
Topics: Administration, Topical; Adolescent; Adult; Anesthetics, Local; Child; Double-Blind Method; Female; | 2007 |
Safety and efficacy of new glyceryl trinitrate suppository formula: first double blind placebo-controlled clinical trial.
Topics: Abietanes; Adolescent; Adult; Chronic Disease; Colonoscopy; Cross-Over Studies; Double-Blind Method; | 2008 |
Topical nitroglycerin therapy for anal fissures and ulcers.
Topics: Administration, Topical; Adult; Anus Diseases; Female; Fissure in Ano; Humans; Male; Nitroglycerin; | 1995 |
A randomised, prospective, double-blind, placebo-controlled trial of glyceryl trinitrate ointment in treatment of anal fissure.
Topics: Administration, Topical; Chronic Disease; Double-Blind Method; Fissure in Ano; Humans; Nitroglycerin | 1997 |
Glyceryl trinitrate is an effective treatment for anal fissure.
Topics: Administration, Cutaneous; Adolescent; Adult; Chronic Disease; Female; Fissure in Ano; Humans; Male; | 1997 |
Local nitroglycerin for treatment of anal fissures: an alternative to lateral sphincterotomy?
Topics: Acute Disease; Administration, Rectal; Administration, Topical; Adult; Anal Canal; Anesthetics, Loca | 1997 |
Glyceryl trinitrate vs. sphincterotomy for treatment of chronic fissure-in-ano: a randomized, controlled trial.
Topics: Administration, Topical; Adult; Aged; Anal Canal; Chronic Disease; Female; Fissure in Ano; Follow-Up | 1997 |
Nitroglycerin--is it good for more than hearts?
Topics: Fissure in Ano; Humans; Manometry; Nitroglycerin; Ointments; Prospective Studies; Time Factors; Vaso | 1998 |
Randomised controlled trial shows that glyceryl trinitrate heals anal fissures, higher doses are not more effective, and there is a high recurrence rate.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Dose-Response Relationship, Drug; Double-Blind Meth | 1999 |
A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Anal Canal; Botulinum Toxins, Type A; Chronic Disease; Cross-Over St | 1999 |
A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Anal Canal; Botulinum Toxins, Type A; Chronic Disease; Cross-Over St | 1999 |
A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Anal Canal; Botulinum Toxins, Type A; Chronic Disease; Cross-Over St | 1999 |
A comparison of injections of botulinum toxin and topical nitroglycerin ointment for the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Anal Canal; Botulinum Toxins, Type A; Chronic Disease; Cross-Over St | 1999 |
Lateral internal sphincterotomy is not redundant in the era of glyceryl trinitrate therapy for chronic anal fissure.
Topics: Adult; Aged; Chronic Disease; Female; Fissure in Ano; Follow-Up Studies; Humans; Male; Middle Aged; | 1999 |
Glyceryl trinitrate ointment for the treatment of chronic anal fissure: results of a placebo-controlled trial and long-term follow-up.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Chronic Disease; Double-Blind Method; Femal | 1999 |
A prospective, randomized, double-blind, placebo-controlled trial of glyceryl-trinitrate ointment in the treatment of children with anal fissure.
Topics: Child; Child, Preschool; Double-Blind Method; Female; Fissure in Ano; Humans; Infant; Male; Nitrogly | 1999 |
Glyceryl trinitrate for chronic anal fissure--healing or headache? Results of a multicenter, randomized, placebo-controled, double-blind trial.
Topics: Adult; Anal Canal; Blood Flow Velocity; Chronic Disease; Double-Blind Method; Female; Fissure in Ano | 2000 |
Audit of topical glyceryl trinitrate for treatment of fissure-in-ano.
Topics: Acute Disease; Adult; Aged; Chronic Disease; Female; Fissure in Ano; Follow-Up Studies; Headache; Hu | 2000 |
Nonoperative management of chronic anal fissure.
Topics: Administration, Rectal; Double-Blind Method; Fissure in Ano; Humans; Nitroglycerin; Treatment Outcom | 2000 |
Are non-surgical treatments for anal fissure effective?
Topics: Administration, Topical; Adult; Anti-Dyskinesia Agents; Botulinum Toxins; Female; Fissure in Ano; Hu | 2000 |
Glyceryl trinitrate treatment of chronic fissure in ano: one year's experience with 0.5% GTN paste.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Drug Administr | 2000 |
Internal sphincterotomy is superior to topical nitroglycerin in the treatment of chronic anal fissure: results of a randomized, controlled trial by the Canadian Colorectal Surgical Trials Group.
Topics: Administration, Topical; Adult; Aged; Anal Canal; Female; Fissure in Ano; Humans; Male; Middle Aged; | 2000 |
A randomized trial of glyceryl trinitrate ointment and nitroglycerin patch in healing of anal fissures.
Topics: Administration, Cutaneous; Adult; Chronic Disease; Female; Fissure in Ano; Humans; Male; Middle Aged | 2000 |
Glyceryl trinitrate for fissures: patch or paste?
Topics: Administration, Cutaneous; Anal Canal; Chronic Disease; Fissure in Ano; Humans; Manometry; Nitroglyc | 2000 |
Double-blind manometric assessment of two topical glyceryl trinitrate formulations in patients with chronic anal fissures.
Topics: Administration, Topical; Adult; Anal Canal; Chronic Disease; Cross-Over Studies; Double-Blind Method | 2000 |
Double blind randomised controlled trial of topical glyceryl trinitrate in anal fissure.
Topics: Acute Disease; Cathartics; Child, Preschool; Defecation; Double-Blind Method; Drug Therapy, Combinat | 2001 |
Double blind randomised controlled trial of topical glyceryl trinitrate in anal fissure.
Topics: Acute Disease; Cathartics; Child, Preschool; Defecation; Double-Blind Method; Drug Therapy, Combinat | 2001 |
Double blind randomised controlled trial of topical glyceryl trinitrate in anal fissure.
Topics: Acute Disease; Cathartics; Child, Preschool; Defecation; Double-Blind Method; Drug Therapy, Combinat | 2001 |
Double blind randomised controlled trial of topical glyceryl trinitrate in anal fissure.
Topics: Acute Disease; Cathartics; Child, Preschool; Defecation; Double-Blind Method; Drug Therapy, Combinat | 2001 |
Glyceryl trinitrate vs. lateral sphincterotomy for chronic anal fissure: prospective, randomized trial.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Anal Canal; Chronic Disease; Fe | 2001 |
Long-term results of topical nitroglycerin in the treatment of chronic anal fissures are disappointing.
Topics: Acute Disease; Administration, Topical; Adult; Aged; Chronic Disease; Female; Fissure in Ano; Follow | 2001 |
Randomized clinical trial assessing the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissure.
Topics: Adult; Aged; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Female; Fissure in Ano; Foll | 2002 |
81 other studies available for nitroglycerin and Anal Fissure
| Article | Year |
|---|---|
Contact allergy to topical diltiazem with co-sensitization to glyceryl trinitrate.
Topics: Administration, Topical; Dermatitis, Allergic Contact; Diltiazem; Fissure in Ano; Humans; Nitroglyce | 2022 |
High Recurrence Rate After Nonsurgical Treatment of Chronic Anal Fissure: Can It Be Prevented?
Topics: Anal Canal; Botulinum Toxins, Type A; Chronic Disease; Fissure in Ano; Humans; Nitroglycerin; Recurr | 2022 |
Causes and Management of Pruritus Ani.
Topics: Fissure in Ano; Hemorrhoids; Humans; Male; Methylene Blue; Middle Aged; Nitroglycerin; Pruritus Ani | 2023 |
Causes and Management of Pruritus Ani.
Topics: Fissure in Ano; Hemorrhoids; Humans; Male; Methylene Blue; Middle Aged; Nitroglycerin; Pruritus Ani | 2023 |
Causes and Management of Pruritus Ani.
Topics: Fissure in Ano; Hemorrhoids; Humans; Male; Methylene Blue; Middle Aged; Nitroglycerin; Pruritus Ani | 2023 |
Causes and Management of Pruritus Ani.
Topics: Fissure in Ano; Hemorrhoids; Humans; Male; Methylene Blue; Middle Aged; Nitroglycerin; Pruritus Ani | 2023 |
Topical treatments for anal fissure.
Topics: Administration, Topical; Anal Canal; Chronic Disease; Fissure in Ano; Humans; Nitroglycerin; Treatme | 2023 |
On Practice Guidelines for the Management of Anal Fissures.
Topics: Anal Canal; Chronic Disease; Fissure in Ano; Humans; Nitroglycerin | 2023 |
Invited commentary on "Topical 5% minoxidil versus topical 0.2% glyceryl trinitrate in treatment of chronic anal fissure: A randomized clinical trial".
Topics: Fissure in Ano; Humans; Minoxidil; Nitroglycerin; Treatment Outcome; Vasodilator Agents | 2020 |
Invited Commentary on: "Topical 5% Minoxidil versus topical 0.2% glyceryl trinitrate in treatment of chronic anal fissure".
Topics: Fissure in Ano; Humans; Minoxidil; Nitroglycerin; Treatment Outcome; Vasodilator Agents | 2020 |
Chronic Migraine With Apparent Loss of Response to Onabotulinum Toxin Type A Due to Local Nitroglycerin Treatment for an Anal Fissure: A Case Report.
Topics: Adult; Botulinum Toxins, Type A; Female; Fissure in Ano; Humans; Migraine Disorders; Neuromuscular A | 2020 |
Does the duration of symptoms of anal fissure impact its response to conservative treatment? A prospective cohort study.
Topics: Acute Disease; Adolescent; Adult; Aged; Chronic Disease; Conservative Treatment; Constipation; Femal | 2017 |
Anal fissure: diagnosis, management, and referral in primary care.
Topics: Administration, Topical; Botulinum Toxins, Type A; Conservative Treatment; Dietary Fiber; Fissure in | 2019 |
Modified-release ointment with nitroglycerin β-cyclodextrin inclusion complex for treatment of anal fissures.
Topics: Adult; beta-Cyclodextrins; Cadaver; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Car | 2013 |
Combined approach in the treatment of chronic anal fissures.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Digestive Syst | 2015 |
0.4% glyceryl trinitrate ointment: new drug. Not useful for anal fissures.
Topics: Adult; Chronic Disease; Clinical Trials as Topic; Fissure in Ano; France; Humans; Nitroglycerin; Oin | 2008 |
Botulinum toxin for recurrent anal fissure following lateral internal sphincterotomy (Br J Surg 2008; 95: 774-778).
Topics: Botulinum Toxins, Type A; Chronic Disease; Fissure in Ano; Humans; Neuromuscular Agents; Nitroglycer | 2008 |
[The role of glyceryl trinitrate in the treatment of anal fissure].
Topics: Acute Disease; Adult; Anal Canal; Chronic Disease; Diagnosis, Differential; Female; Fissure in Ano; | 2008 |
Glyceryl trinitrate: the management of chronic anal fissure in patients who are unfit for surgery.
Topics: Chronic Disease; Fissure in Ano; Humans; Nitroglycerin; Vasodilator Agents | 2008 |
Diltiazem (2%) versus glyceryl trinitrate cream (0.2%) in the management of chronic anal fissure.
Topics: Adolescent; Adult; Aged; Calcium Channel Blockers; Chronic Disease; Diltiazem; Female; Fissure in An | 2009 |
Subcutaneous internal lateral sphincterotomy (SILS) versus nitroglycerine ointment in anal fissure: a prospective study.
Topics: Adult; Anal Canal; Female; Fissure in Ano; Humans; Male; Nitroglycerin; Ointments; Patient Complianc | 2010 |
Conservative and surgical treatment of chronic anal fissure: prospective longer term results.
Topics: Administration, Topical; Adult; Botulinum Toxins; Chronic Disease; Cohort Studies; Dilatation; Femal | 2010 |
Efficacy of management algorithm for reducing need for sphincterotomy in chronic anal fissures.
Topics: Algorithms; Botulinum Toxins, Type A; Chronic Disease; Female; Fissure in Ano; Humans; Male; Neuromu | 2012 |
Treatment of chronic anal fissure with topical nitroglycerin ointment 0.4%: a prospective clinical study.
Topics: Administration, Topical; Chronic Disease; Dose-Response Relationship, Drug; Fissure in Ano; Humans; | 2011 |
Nitroglycerin ointment (Rectiv) for anal fissure.
Topics: Administration, Topical; Chronic Disease; Fissure in Ano; Humans; Nitroglycerin; Ointments; Pain; Va | 2012 |
[Anorectal diseases: an update].
Topics: Anus Diseases; Biofeedback, Psychology; Electric Stimulation Therapy; Fecal Incontinence; Fissure in | 2012 |
Randomized clinical trial assessing the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissure (Br J Surg 2002; 89: 413-17).
Topics: Chronic Disease; Diltiazem; Fissure in Ano; Humans; Nitroglycerin; Randomized Controlled Trials as T | 2002 |
Randomized clinical trial assessing the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissure (Br J Surg 2002; 89: 413-17).
Topics: Chronic Disease; Diltiazem; Fissure in Ano; Humans; Isosorbide Dinitrate; Nitric Oxide Donors; Nitro | 2002 |
Diltiazem heals glyceryl trinitrate-resistant chronic anal fissures: a prospective study.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Calcium Channel Blockers; Chronic Disease; | 2002 |
Randomized clinical trial assessing the side-effects of glyceryl trinitrate and diltiazem hydrochloride in the treatment of chronic anal fissure (Br J Surg 2002; 89: 413-17).
Topics: Chronic Disease; Diltiazem; Fissure in Ano; Humans; Nitroglycerin; Randomized Controlled Trials as T | 2002 |
American Gastroenterological Association medical position statement: Diagnosis and care of patients with anal fissure.
Topics: Administration, Topical; Botulinum Toxins; Digestive System Surgical Procedures; Fissure in Ano; Hum | 2003 |
Creation of a treatment protocol for nurse-led management of anal fissure.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Clinical Protocols; Female; Fissure in Ano; Humans; Male | 2003 |
Placebo treatment for anal fissure.
Topics: Botulinum Toxins; Chronic Disease; Fissure in Ano; Humans; Nitroglycerin; Placebos | 2003 |
Practice parameters for the management of anal fissures (revised).
Topics: Botulinum Toxins, Type A; Calcium Channel Blockers; Colorectal Surgery; Evidence-Based Medicine; Fis | 2004 |
Pharmacologic treatments maintain an important role in the treatment of anal fissure.
Topics: Fecal Incontinence; Fissure in Ano; Follow-Up Studies; Humans; Nitroglycerin; Patient Selection; Pos | 2004 |
Long-term results of topical glyceryl trinitrate ointment in children with anal fissure.
Topics: Administration, Topical; Anal Canal; Child; Chronic Disease; Female; Fissure in Ano; Follow-Up Studi | 2005 |
Pharmacologic therapy of anal fissure: worth the wait?
Topics: Anal Canal; Chronic Disease; Fissure in Ano; Humans; Neuromuscular Agents; Nitroglycerin; Vasodilato | 2005 |
Nonsurgical treatment of chronic anal fissure: nitroglycerin and dilatation versus nifedipine and botulinum toxin.
Topics: Administration, Topical; Adult; Anti-Dyskinesia Agents; Botulinum Toxins; Catheterization; Chronic D | 2006 |
0.4% nitroglycerin ointment in the treatment of chronic anal fissure pain: a viewpoint by Richard Nelson.
Topics: Administration, Topical; Chronic Disease; Fissure in Ano; Humans; Nitric Oxide Donors; Nitroglycerin | 2006 |
0.4% nitroglycerin ointment in the treatment of chronic anal fissure pain : a viewpoint by Jonathan N. Lund.
Topics: Administration, Topical; Chronic Disease; Fissure in Ano; Humans; Meta-Analysis as Topic; Nitric Oxi | 2006 |
0.4% nitroglycerin ointment in the treatment of chronic anal fissure pain : a viewpoint by Laurence R. Sands.
Topics: Administration, Topical; Chronic Disease; Fissure in Ano; Humans; Nitric Oxide Donors; Nitroglycerin | 2006 |
Chemical sphincterotomy in the treatment of anal fissure.
Topics: Botulinum Toxins, Type A; Calcium Channel Blockers; Fissure in Ano; Humans; Nitric Oxide Donors; Nit | 2006 |
An evidence-based treatment algorithm for anal fissure.
Topics: Algorithms; Fissure in Ano; Humans; Isosorbide Dinitrate; Nitric Oxide Donors; Nitroglycerin | 2006 |
Chemical versus surgical sphincterotomy for chronic fissure in ano.
Topics: Adult; Anal Canal; Chronic Disease; Female; Fissure in Ano; Humans; Male; Nitroglycerin; Treatment O | 2007 |
Randomized clinical trial comparing botulinum toxin injections with 0.2 per cent nitroglycerin ointment for chronic anal fissure (Br J Surg 2007; 94: 162-167).
Topics: Administration, Topical; Botulinum Toxins, Type A; Chronic Disease; Fissure in Ano; Humans; Injectio | 2007 |
Variation in clinical, manometric and endosonographic findings in anterior chronic anal fissure: a prospective study.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Endosonography; Female; Fissure in Ano; Follow-Up S | 2008 |
GTN headaches and reduction of natural banding?
Topics: Administration, Topical; Dose-Response Relationship, Drug; Fissure in Ano; Follow-Up Studies; Headac | 2008 |
[Nitroglycerin-Rectogesic].
Topics: Drug Interactions; Fissure in Ano; Humans; Nitroglycerin; Ointments; Vasodilator Agents | 2007 |
Topical therapy is first line treatment for chronic anal fissure because of the risk of incontinence with sphincterotomy.
Topics: Administration, Topical; Chronic Disease; Defecation; Digestive System Surgical Procedures; Fecal In | 2008 |
Treatment of benign anal disease with topical nitroglycerin.
Topics: Administration, Topical; Adult; Anal Canal; Defecation; Female; Fissure in Ano; Follow-Up Studies; H | 1995 |
Topical glyceryl trinitrate in the treatment of chronic anal fissure.
Topics: Administration, Topical; Adult; Aged; Anal Canal; Chronic Disease; Dose-Response Relationship, Drug; | 1996 |
Use of glyceryl trinitrate ointment in the treatment of anal fissure.
Topics: Administration, Topical; Adult; Chronic Disease; Female; Fissure in Ano; Humans; Male; Manometry; Ni | 1996 |
Glyceryl trinitrate for anal fissure.
Topics: Anal Canal; Fissure in Ano; Humans; Nitric Oxide; Nitroglycerin | 1996 |
The use of glyceryl trinitrate in inexaminable patients with anal fissure.
Topics: Administration, Sublingual; Adult; Aged; Female; Fissure in Ano; Humans; Male; Middle Aged; Nitrogly | 1996 |
Use of glyceryl trinitrate ointment in the treatment of anal fissure.
Topics: Fissure in Ano; Humans; Nitroglycerin; Ointments | 1996 |
Glyceryl trinitrate ointment for chronic anal fissure.
Topics: Chronic Disease; Fissure in Ano; Headache; Humans; Nitroglycerin; Ointments | 1997 |
Topical treatment of chronic anal fissures.
Topics: Adult; Chronic Disease; Double-Blind Method; Female; Fissure in Ano; Humans; Male; Nitroglycerin; Oi | 1997 |
Treating anal fissure.
Topics: Fissure in Ano; Humans; Nitroglycerin; Ointments | 1997 |
Successful treatment of fissure in ano using topical nitroglycerin.
Topics: Administration, Topical; Adult; Female; Fissure in Ano; Humans; Male; Middle Aged; Nitroglycerin | 1997 |
[Heart in the pants: treatment of chronic anal fissure with nitrate ointment].
Topics: Administration, Rectal; Double-Blind Method; Fissure in Ano; Humans; Isosorbide Dinitrate; Nitroglyc | 1997 |
Internal sphincter spasm in anal fissure.
Topics: Adolescent; Adult; Aged; Female; Fissure in Ano; Humans; Male; Middle Aged; Nitroglycerin; Ointments | 1997 |
Say NO to anal fissures.
Topics: Anti-Ulcer Agents; Drug Delivery Systems; Fissure in Ano; Humans; Hydrogel, Polyethylene Glycol Dime | 1998 |
[Topical nitroglycerin in the treatment of anal fissure].
Topics: Administration, Topical; Fissure in Ano; Humans; Nitroglycerin; Vasodilator Agents | 1998 |
Topical glyceryl trinitrate cream for anal fissure.
Topics: Administration, Topical; Adult; Fissure in Ano; Humans; Male; Middle Aged; Nitroglycerin; Ointments; | 1998 |
Changing patterns of treatment for chronic anal fissure.
Topics: Adolescent; Adult; Chronic Disease; Dilatation; Female; Fissure in Ano; Humans; Male; Middle Aged; N | 1998 |
[Nitroglycerin ointment is a mild treatment agent for anal fissure. Surgery may cause permanent injury to the internal anal sphincter].
Topics: Administration, Rectal; Anal Canal; Fissure in Ano; Humans; Muscle Relaxation; Nitroglycerin; Ointme | 1998 |
Topical nitroglycerin in the management of anal fissure: an explosive outcome!
Topics: Administration, Topical; Adult; Aged; Anal Canal; Combined Modality Therapy; Dose-Response Relations | 1998 |
Follow-up of patients with chronic anal fissure treated with topical glyceryl trinitrate.
Topics: Administration, Cutaneous; Chronic Disease; Fissure in Ano; Follow-Up Studies; Humans; Nitroglycerin | 1998 |
Nitroglycerin ointment for anal fissures: effective treatment or just a headache?
Topics: Acute Disease; Chronic Disease; Female; Fissure in Ano; Humans; Male; Nitroglycerin; Ointments; Pros | 1999 |
One man's poison--clinical applications of botulinum toxin.
Topics: Administration, Topical; Botulinum Toxins; Botulinum Toxins, Type A; Fissure in Ano; Humans; Injecti | 1999 |
Treatment of chronic anal fissure with topical glyceryl trinitrate.
Topics: Administration, Topical; Adolescent; Adult; Aged; Chronic Disease; Female; Fissure in Ano; Humans; M | 1999 |
Headaches in the treatment of anal fissure.
Topics: Administration, Topical; Fecal Incontinence; Fissure in Ano; Headache; Humans; Nitroglycerin; Vasodi | 1999 |
A comparison of botulinum toxin and nitroglycerin ointment for chronic anal fissure.
Topics: Botulinum Toxins; Chronic Disease; Fissure in Ano; Humans; Nitroglycerin | 1999 |
A comparison of botulinum toxin and nitroglycerin ointment for chronic anal fissure.
Topics: Botulinum Toxins; Chronic Disease; Drug Therapy, Combination; Fissure in Ano; Humans; Nitroglycerin; | 1999 |
Practice tips. Novel uses for nitroglycerin.
Topics: Adult; Biliary Tract Diseases; Child; Colic; Delivery, Obstetric; Esophageal Spasm, Diffuse; Female; | 2000 |
[Anal fissure--a new therapy concept].
Topics: Administration, Topical; Anal Canal; Botulinum Toxins, Type A; Fissure in Ano; Humans; Injections, I | 2000 |
[News in the anorectal area. Heart salve and stapler against anal diseases].
Topics: Fissure in Ano; Hemorrhoids; Humans; Nitroglycerin; Ointments; Surgical Staplers | 2000 |
Short- and long-term effect of glyceryl trinitrate (GTN) ointment 0.2% and 2% on anal canal pressure in patients with chronic anal fissures.
Topics: Adult; Anal Canal; Chronic Disease; Female; Fissure in Ano; Humans; Male; Nitroglycerin; Ointments; | 2000 |
Treatment of anal fissure with glyceryl trinitrate in patients referred for surgical management.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Female; Fissure in Ano; General Surgery; Humans; Ma | 2001 |
Reasons for failure of glyceryl trinitrate treatment of chronic fissure-in-ano: a multivariate analysis.
Topics: Administration, Topical; Adult; Chronic Disease; Female; Fissure in Ano; Humans; Male; Middle Aged; | 2001 |
Audit of topical glyceryl trinitrate for treatment of fissure-in-ano.
Topics: Fissure in Ano; Follow-Up Studies; Humans; Medical Audit; Nitroglycerin; Ointments; Vasodilator Agen | 2001 |
Re: Thompson--The knife is better than nitro.
Topics: Administration, Topical; Algorithms; Botulinum Toxins; Catheterization; Combined Modality Therapy; D | 2001 |
Effect of topical glyceryl trinitrate on anodermal blood flow in patients with chronic anal fissures.
Topics: Administration, Topical; Adult; Anal Canal; Female; Fissure in Ano; Humans; Male; Nitroglycerin; Pro | 2001 |
Modelling the economic impact of managing a chronic anal fissure with a proprietary formulation of nitroglycerin (Rectogesic) compared to lateral internal sphincterotomy in the United Kingdom.
Topics: Anal Canal; Cost Control; Decision Trees; Fissure in Ano; Health Care Costs; Health Resources; Human | 2002 |