Page last updated: 2024-11-01

nitroglycerin and Alloxan Diabetes

nitroglycerin has been researched along with Alloxan Diabetes in 34 studies

Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.

Research Excerpts

ExcerptRelevanceReference
"Pretreatment with diphenhydramine (5 x 10(-7)) on aortic rings from 12 and 52-week age matched rats resulted in qualitatively similar histamine dose-response curves that were displaced about two orders of magnitude to the right, indicative of H1 receptor competitive antagonism."1.28Histamine relaxation of aortic rings from diabetic rats. ( Chang, KS; Tanz, RD; Weller, TS, 1989)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19903 (8.82)18.7374
1990's20 (58.82)18.2507
2000's6 (17.65)29.6817
2010's3 (8.82)24.3611
2020's2 (5.88)2.80

Authors

AuthorsStudies
Gajos-Draus, A1
Duda, M1
Beresewicz, A1
Van Hove, L1
Hamada, E1
Ebi, N1
Miyagi-Shiohira, C1
Tamaki, Y1
Nakashima, Y1
Kobayashi, N1
Saitoh, I1
Watanabe, M1
Kinjo, T1
Noguchi, H1
Gurney, AM1
Howarth, FC1
Araiza-Saldaña, CI1
Rocha-González, HI1
Ambriz-Tututi, M1
Castañeda-Corral, G1
Caram-Salas, NL1
Hong, E1
Granados-Soto, V1
Mayhan, WG10
Arrick, DM2
Patel, KP3
Sun, H3
Jariyapongskul, A1
Patumraj, S1
Niimi, H1
Wendt, MC1
Daiber, A1
Kleschyov, AL1
Mülsch, A1
Sydow, K1
Schulz, E1
Chen, K1
Keaney, JF1
Lassègue, B1
Walter, U1
Griendling, KK1
Münzel, T1
Sharpe, GM1
Pieper, GM9
Jordan, M3
Adams, MB3
Roza, AM4
Peltier, BA1
Komers, R1
Allen, TJ1
Cooper, ME1
Faraci, FM1
Didion, SP1
Keegan, A2
Walbank, H1
Cotter, MA2
Cameron, NE2
Siebeneich, W2
Langenstroer, P1
Trauernicht, AK1
Irvine, SD2
Vlassara, H1
Fuh, H1
Makita, Z1
Krungkrai, S1
Cerami, A1
Bucala, R1
Matsuzaki, T1
Sakanashi, M1
Kiff, RJ1
Gardiner, SM1
Compton, AM1
Bennett, T1
Tanz, RD2
Chang, KS2
Weller, TS2
Gross, GJ1

Other Studies

34 other studies available for nitroglycerin and Alloxan Diabetes

ArticleYear
Exercise and nitrite prevent and Nω-nitrol-L-arginine methyl ester reproduces imbalance in the nuclear factor-κB/NADPH oxidase 2 and nuclear factor erythroid 2-related factor 2/NADPH oxidase 4/endothelial nitric oxide synthase systems in diabetes.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2021, Volume: 72, Issue:5

    Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Hydrogen Peroxide; NADPH Oxidase 2; NADPH Oxidas

2021
A Cannabinoid Type 2 (CB2) Receptor Agonist Augments NOS-Dependent Responses of Cerebral Arterioles During Type 1 Diabetes.
    South Dakota medicine : the journal of the South Dakota State Medical Association, 2022, Volume: 75, Issue:10

    Topics: Adenosine Diphosphate; Animals; Arterioles; Cannabinoid Receptor Agonists; Cannabinoids; Diabetes Me

2022
Comparison Between Modified Extracellular-Type Trehalose-Containing Kyoto Solution and University of Wisconsin Solution in 18-Hour Pancreas Preservation for Islet Transplantation.
    Pancreas, 2018, Volume: 47, Issue:7

    Topics: Acetylcysteine; Adenosine; Allopurinol; Animals; Blood Glucose; Bucladesine; Diabetes Mellitus, Expe

2018
Effects of streptozotocin-induced diabetes on the pharmacology of rat conduit and resistance intrapulmonary arteries.
    Cardiovascular diabetology, 2009, Jan-21, Volume: 8

    Topics: Animals; Calcium Signaling; Carbachol; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dinop

2009
Sildenafil and glyceryl trinitrate reduce tactile allodynia in streptozotocin-injected rats.
    European journal of pharmacology, 2010, Apr-10, Volume: 631, Issue:1-3

    Topics: Administration, Cutaneous; Analgesics; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Diabet

2010
Exercise training normalizes impaired NOS-dependent responses of cerebral arterioles in type 1 diabetic rats.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:3

    Topics: Adenosine Diphosphate; Animals; Arterioles; Cerebral Arteries; Cerebral Cortex; Diabetes Mellitus, E

2011
Cerebral endothelial dysfunction in diabetes: intravital microscopic analysis using streptozotocin-induced diabetic rats.
    Clinical hemorheology and microcirculation, 2003, Volume: 29, Issue:3-4

    Topics: Acetylcholine; Animals; Arterioles; Cell Adhesion; Cerebrovascular Circulation; Diabetes Mellitus, E

2003
Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4.
    Free radical biology & medicine, 2005, Aug-01, Volume: 39, Issue:3

    Topics: Acetylcholine; Animals; Aorta; Blotting, Western; Cell Adhesion Molecules; Diabetes Mellitus, Experi

2005
Diabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase.
    Microvascular research, 2007, Volume: 73, Issue:1

    Topics: Acetylcholine; Adenosine Diphosphate; Animals; Arterioles; Blood Glucose; Blood Pressure; Body Weigh

2007
Syngeneic pancreatic islet transplantation reverses endothelial dysfunction in experimental diabetes.
    Diabetes, 1995, Volume: 44, Issue:9

    Topics: Acetylcholine; Amino Acids; Animals; Aorta, Thoracic; Blood Glucose; Body Weight; Diabetes Mellitus,

1995
Amelioration by L-arginine of a dysfunctional arginine/nitric oxide pathway in diabetic endothelium.
    Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:3

    Topics: Acetylcholine; Amino Acids; Animals; Arginine; Body Weight; Calcimycin; Diabetes Mellitus, Experimen

1995
Role of endothelium-derived nitric oxide in the pathogenesis of the renal hemodynamic changes of experimental diabetes.
    Diabetes, 1994, Volume: 43, Issue:10

    Topics: Animals; Arginine; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dose-Res

1994
Effect of diabetes mellitus on response of the basilar artery to activation of ATP-sensitive potassium channels.
    Brain research, 1994, Feb-04, Volume: 636, Issue:1

    Topics: Adenosine Triphosphate; Animals; Basilar Artery; Benzopyrans; Blood Pressure; Cromakalim; Diabetes M

1994
Responses of cerebral arterioles to activation of beta-adrenergic receptors during diabetes mellitus.
    Stroke, 1994, Volume: 25, Issue:1

    Topics: Animals; Arginine; Arterioles; Cerebrovascular Circulation; Colforsin; Diabetes Mellitus, Experiment

1994
Responses of cerebral arterioles in diabetic rats to activation of ATP-sensitive potassium channels.
    The American journal of physiology, 1993, Volume: 265, Issue:1 Pt 2

    Topics: Adenosine Triphosphate; Animals; Arginine; Arterioles; Cerebrovascular Circulation; Diabetes Mellitu

1993
L-Arginine does not restore dilatation of the basilar artery during diabetes mellitus.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1996, Volume: 16, Issue:3

    Topics: Acetylcholine; Animals; Arginine; Basilar Artery; Bradykinin; Diabetes Mellitus, Experimental; Male;

1996
Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta.
    Diabetologia, 1995, Volume: 38, Issue:12

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Diabetes Mellitus, Experimental; Dose-Response Relationship

1995
Chronic treatment in vivo with dimethylthiourea, a hydroxyl radical scavenger, prevents diabetes-induced endothelial dysfunction.
    Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:6

    Topics: Acetylcholine; Animals; Aorta; Blood Glucose; Calcimycin; Catalase; Diabetes Mellitus, Experimental;

1996
Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin.
    Journal of cardiovascular pharmacology, 1997, Volume: 29, Issue:1

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Diabetes Mellitus, Experimental; Endothelium, Vascular; In

1997
Diabetic-induced endothelial dysfunction in rat aorta: role of hydroxyl radicals.
    Cardiovascular research, 1997, Volume: 34, Issue:1

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Catalase; Cyclooxygenase Inhibitors; Diabetes Mellitus, Exp

1997
Superoxide dismutase partially restores impaired dilatation of the basilar artery during diabetes mellitus.
    Brain research, 1997, Jun-20, Volume: 760, Issue:1-2

    Topics: Acetylcholine; Animals; Basilar Artery; Bradykinin; Diabetes Mellitus, Experimental; Dose-Response R

1997
Chronic treatment with the 21-aminosteroid U74389F, an inhibitor of lipid peroxidation, does not prevent diabetic endothelial dysfunction.
    Cardiovascular drugs and therapy, 1997, Volume: 11, Issue:3

    Topics: Acetylcholine; Animals; Antioxidants; Aorta, Thoracic; Blood Glucose; Body Weight; Calcimycin; Catal

1997
Pancreatic transplantation reverses endothelial dysfunction in experimental diabetes mellitus.
    Surgery, 1998, Volume: 123, Issue:1

    Topics: Acetylcholine; Amino Acids; Animals; Aorta, Abdominal; Blood Glucose; Diabetes Mellitus, Experimenta

1998
Treatment with dimethylthiourea prevents impaired dilatation of the basilar artery during diabetes mellitus.
    The American journal of physiology, 1998, Volume: 274, Issue:6

    Topics: Acetylcholine; Animals; Basilar Artery; Diabetes Mellitus, Experimental; Free Radical Scavengers; Ma

1998
Enhanced, unaltered and impaired nitric oxide-mediated endothelium-dependent relaxation in experimental diabetes mellitus: importance of disease duration.
    Diabetologia, 1999, Volume: 42, Issue:2

    Topics: Acetylcholine; Animals; Aorta; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibi

1999
Effects of chelator treatment on aorta and corpus cavernosum from diabetic rats.
    Free radical biology & medicine, 1999, Volume: 27, Issue:5-6

    Topics: Acetylcholine; Animals; Aorta; Blood Glucose; Chelating Agents; Diabetes Mellitus, Experimental; Ele

1999
Insulin reverses impaired acetylcholine-induced dilatation of the rat basilar artery during diabetes mellitus.
    Brain research, 2001, Mar-02, Volume: 893, Issue:1-2

    Topics: Acetylcholine; Administration, Topical; Animals; Basilar Artery; Blood Glucose; Diabetes Mellitus, E

2001
Influence of gender on dilatation of the basilar artery during diabetes mellitus.
    Brain research, 2002, Mar-15, Volume: 930, Issue:1-2

    Topics: Acetylcholine; Animals; Basilar Artery; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental;

2002
Exogenous advanced glycosylation end products induce complex vascular dysfunction in normal animals: a model for diabetic and aging complications.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Dec-15, Volume: 89, Issue:24

    Topics: Acetylcholine; Aging; Animals; Blood Pressure; Capillary Permeability; Diabetes Mellitus, Experiment

1992
Comparison of the development of tolerance to nitroglycerin in aortic preparations isolated from non-diabetic and diabetic rats.
    Heart and vessels, 1992, Volume: 7, Issue:1

    Topics: Acetylcysteine; Animals; Aorta, Thoracic; Blood Glucose; Culture Techniques; Diabetes Mellitus, Expe

1992
Selective impairment of hindquarters vasodilator responses to bradykinin in conscious Wistar rats with streptozotocin-induced diabetes mellitus.
    British journal of pharmacology, 1991, Volume: 103, Issue:2

    Topics: Acetylcholine; Animals; Arginine; Blood Glucose; Blood Pressure; Bradykinin; Diabetes Mellitus, Expe

1991
Histamine relaxation of aortic rings from diabetic rats.
    Agents and actions, 1989, Volume: 28, Issue:1-2

    Topics: Animals; Aorta, Thoracic; Diabetes Mellitus, Experimental; Diphenhydramine; Endothelium, Vascular; H

1989
Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta.
    The American journal of physiology, 1988, Volume: 255, Issue:4 Pt 2

    Topics: Acetylcholine; Adenosine Diphosphate; Animals; Aorta, Thoracic; Ascorbic Acid; Catalase; Diabetes Me

1988
Diabetic duration and rat aortic responsiveness to histamine and nitroglycerin.
    Proceedings of the Western Pharmacology Society, 1988, Volume: 31

    Topics: Animals; Aorta, Thoracic; Diabetes Mellitus, Experimental; Histamine; In Vitro Techniques; Male; Nit

1988