nitroglycerin has been researched along with Abdominal Migraine in 237 studies
Nitroglycerin: A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
nitroglycerol : A nitrate ester that is glycerol in which nitro group(s) replace the hydrogen(s) attached to one or more of the hydroxy groups.
nitroglycerin : A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Nitroglycerin (NTG) administration commonly causes a headache with some features similar to those of a migraine." | 9.09 | The pharmacodynamics of sumatriptan in nitroglycerin-induced headache. ( Forrest, A; Fullerton, T; Gengo, FM; Komorowski-Swiatek, D, 1999) |
| " Treatment with GLP-1R agonist liraglutide attenuated trigeminal allodynia and suppressed the protein levels of CM-associated molecules in the trigeminal nucleus caudalis (TNC)." | 8.31 | GLP-1R agonist liraglutide attenuates pain hypersensitivity by stimulating IL-10 release in a nitroglycerin-induced chronic migraine mouse model. ( Jing, F; Pu, Y; Zou, Q, 2023) |
| " The aim of this study was to analyze the sensitivity of rats with prenatal hyperhomocysteinemia (hHCY) in respect of the development of behavioral correlates of headache and spreading cortical depolarization (CSD) in a migraine model induced by the administration of the nitric oxide (NO) donor nitroglycerin." | 8.12 | Hyperhomocysteinemia Increases Cortical Excitability and Aggravates Mechanical Hyperalgesia and Anxiety in a Nitroglycerine-Induced Migraine Model in Rats. ( Bogatova, K; Enikeev, D; Gerasimova, E; Giniatullin, R; Hermann, A; Sitdikova, G; Yakovleva, O, 2022) |
| "This study aimed to investigate the antimigraine potential of quercetin in migraine pain induced by nitroglycerin (NTG), 10 mg/kg, intraperitoneal injection in rats." | 8.12 | Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators. ( Alam, A; Almalki, HS; Alqarni, MH; Devi, S; Foudah, AI; Kumar, M; Salkini, MA, 2022) |
| "In migraineurs nitroglycerin (NTG) induces severe delayed headache, resembling spontaneous migraine attacks." | 7.72 | Nitroglycerin induces migraine headache and central sensitization phenomena in patients with migraine without aura: a study of laser evoked potentials. ( Cerbo, R; de Tommaso, M; Difruscolo, O; Guido, M; Libro, G; Losito, L; Sardaro, M, 2004) |
| "two types of headache developed after the nitroglycerin administration: (1) an immediate headache that does not fulfil the criteria for migraine, mild and disappears spontaneously within 1 hour; (2) a typical migraine attack without aura develops several hours after the nitroglycerin administration (mean latency: 250 min), moderate or severe, and warrants antimigraine therapy." | 7.72 | [Nitroglycerin-induced headaches]. ( Bagdy, G; Gonda, X; Juhász, G; Zsombók, T, 2004) |
| "Cranial allodynia associated with spontaneous migraine is reported as either responsive to triptan treatment or to be predictive of lack of triptan efficacy." | 6.90 | Nitroglycerine triggers triptan-responsive cranial allodynia and trigeminal neuronal hypersensitivity. ( Akerman, S; Bose, P; Goadsby, PJ; Hoffmann, JR; Holland, PR; Karsan, N; Romero-Reyes, M, 2019) |
| "Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models." | 6.61 | Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back. ( Borsook, D; De Icco, R; Demartini, C; Greco, R; Sances, G; Tassorelli, C; Zanaboni, AM, 2019) |
| "A chronic migraine model was established in mice by repeated injection of nitroglycerin (10 mg/kg, i." | 5.91 | Roxadustat alleviates nitroglycerin-induced migraine in mice by regulating HIF-1α/NF-κB/inflammation pathway. ( Chen, YL; Duan, YJ; Fan, XD; Gao, YY; Han, JH; Liao, CZ; Meng, XS; Sun, L; Wang, XR; Xie, ZL; Yang, DG; Yang, XX; Yin, ZQ; Zou, TF, 2023) |
| "Interestingly, these migraine-associated single-nucleotide polymorphisms reside in noncoding regions of TRPM8, with those correlated with reduced migraine risk exhibiting lower TRPM8 expression and decreased cold sensitivity." | 5.72 | Transient receptor potential melastatin 8 is required for nitroglycerin- and calcitonin gene-related peptide-induced migraine-like pain behaviors in mice. ( Kim, B; McKemy, DD; Wei, C, 2022) |
| "This study shows that the antimigraine effects of DOR agonists can be separated from their proconvulsant effects." | 5.62 | A non-convulsant delta-opioid receptor agonist, KNT-127, reduces cortical spreading depression and nitroglycerin-induced allodynia. ( Asif, S; Bertels, Z; Pradhan, AA; Siegersma, K; van Rijn, RM; Witkowski, WD, 2021) |
| "Migraine is one of the most common neurological disorders characterized by recurrent attacks of typically throbbing and unilateral headaches, affecting up to 20% of the population worldwide." | 5.62 | Protein kinase Cδ as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice. ( He, Y; Kashyap, Y; Messing, RO; Shi, Z; Wang, ZJ, 2021) |
| "Many patients with chronic migraine are difficult to treat." | 5.56 | Chronic Migraine With Apparent Loss of Response to Onabotulinum Toxin Type A Due to Local Nitroglycerin Treatment for an Anal Fissure: A Case Report. ( González-Quintanilla, V; Madera, J; Pascual, J; Pérez-Pereda, S, 2020) |
| "By contrast, cold allodynia, but not mechanical hypersensitivity, occurred in the facial region." | 5.48 | Differential Development of Facial and Hind Paw Allodynia in a Nitroglycerin-Induced Mouse Model of Chronic Migraine: Role of Capsaicin Sensitive Primary Afferents. ( Beitz, AJ; Kim, SJ; Kwon, SG; Lee, JH; Roh, DH; Yeo, JH; Yoon, SY, 2018) |
| "Chronic migraine dramatically affects the quality of life in the migraineurs." | 5.48 | Cerebrolysin attenuates hyperalgesia, photophobia, and neuroinflammation in a nitroglycerin-induced migraine model in rats. ( Erfani, M; Farajdokht, F; Karimi, P; Mahmoudi, J; Mohaddes, G; Rajabi, M; Reyhani-Rad, S; Sadigh-Eteghad, S, 2018) |
| "Chronic migraine is a debilitating disorder that has a significant impact on patients and society." | 5.46 | Chronic ghrelin treatment reduced photophobia and anxiety-like behaviors in nitroglycerin- induced migraine: role of pituitary adenylate cyclase-activating polypeptide. ( Alipour, MR; Babri, S; Bughchechi, R; Farajdokht, F; Karimi, P; Mohaddes, G, 2017) |
| "Migraine headaches are considered to be associated with increased mitochondrial energy metabolism." | 5.42 | Protective effects of riboflavin and selenium on brain microsomal Ca2+-ATPase and oxidative damage caused by glyceryl trinitrate in a rat headache model. ( Bütün, A; Çelik, Ö; Nazıroğlu, M; Uğuz, AC, 2015) |
| "The ability to scan repeatedly a patient without radiation and with non-invasive imaging modalities, as well as the recognition that human experimental migraine provocation compounds, such as nitroglycerin (NTG) and pituitary adenylate cyclase activating polypeptide (PACAP), can trigger typical premonitory symptoms (PS) and migraine-like headache in patients with migraine, have allowed feasible and reproducible imaging of the premonitory phase using NTG." | 5.41 | Neuroimaging in the pre-ictal or premonitory phase of migraine: a narrative review. ( Goadsby, PJ; Karsan, N, 2023) |
| "Migraine was provoked in six (42%) patients by hypoxia, in three (21%) by NTG and in two (14%) by placebo." | 5.33 | Normobaric hypoxia and nitroglycerin as trigger factors for migraine. ( Agosti, RM; Bärtsch, P; Baumgartner, RW; Ferrari, MD; Sándor, PS; Schoonman, GG; Siccoli, M, 2006) |
| " Nitroglycerin (NTG) administration commonly causes a headache with some features similar to those of a migraine." | 5.09 | The pharmacodynamics of sumatriptan in nitroglycerin-induced headache. ( Forrest, A; Fullerton, T; Gengo, FM; Komorowski-Swiatek, D, 1999) |
| "Nitric oxide (NO) may play a key role in migraine and other vascular headaches since glyceryl trinitrate (a donor of NO) and histamine (which probably activates endothelial NO formation) both cause a pulsating dose-dependent headache with several migrainous characteristics." | 4.79 | Nitric oxide is a key molecule in migraine and other vascular headaches. ( Iversen, H; Olesen, J; Thomsen, LL, 1994) |
| " Treatment with GLP-1R agonist liraglutide attenuated trigeminal allodynia and suppressed the protein levels of CM-associated molecules in the trigeminal nucleus caudalis (TNC)." | 4.31 | GLP-1R agonist liraglutide attenuates pain hypersensitivity by stimulating IL-10 release in a nitroglycerin-induced chronic migraine mouse model. ( Jing, F; Pu, Y; Zou, Q, 2023) |
| " The aim of this study was to analyze the sensitivity of rats with prenatal hyperhomocysteinemia (hHCY) in respect of the development of behavioral correlates of headache and spreading cortical depolarization (CSD) in a migraine model induced by the administration of the nitric oxide (NO) donor nitroglycerin." | 4.12 | Hyperhomocysteinemia Increases Cortical Excitability and Aggravates Mechanical Hyperalgesia and Anxiety in a Nitroglycerine-Induced Migraine Model in Rats. ( Bogatova, K; Enikeev, D; Gerasimova, E; Giniatullin, R; Hermann, A; Sitdikova, G; Yakovleva, O, 2022) |
| "Repeated administration of nitroglycerin (NTG) or levcromakalim (LEV) was conducted to stimulate human migraine-like pain and establish two types of CMMs in mice." | 4.12 | A c-Fos activation map in nitroglycerin/levcromakalim-induced models of migraine. ( Li, Z; Liu, X; Ren, X; Wang, W; Wang, Y; Wu, S; Zhang, K; Zhu, C, 2022) |
| "This study aimed to investigate the antimigraine potential of quercetin in migraine pain induced by nitroglycerin (NTG), 10 mg/kg, intraperitoneal injection in rats." | 4.12 | Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators. ( Alam, A; Almalki, HS; Alqarni, MH; Devi, S; Foudah, AI; Kumar, M; Salkini, MA, 2022) |
| "Calcitonin gene-related peptide (CGRP), substance P and dural mast cells are main contributors in neurogenic inflammation underlying migraine pathophysiology." | 4.12 | Receptor mechanisms mediating the anti-neuroinflammatory effects of endocannabinoid system modulation in a rat model of migraine. ( Ankarali, S; Dagistan, Y; Kilinc, E; Torun, IE, 2022) |
| " Then, nitroglycerin (NTG) (5 mg/kg/IP) was used to induce migraine and pain-related symptoms were recorded for 90 min." | 3.96 | Physical exercise enhances vulnerability to migraine headache associated with CGRP up-expression in trigeminal nucleus caudalis of stressed rats. ( Abbasnejad, M; Askari-Zahabi, K; Esmaeili-Mahani, S; Kooshki, R; Raoof, M; Shamsizadeh, A, 2020) |
| " Results VL-102-evoked acute and chronic mechanical cephalic and hind-paw allodynia in a dose-dependent manner, which was blocked by the migraine medications sumatriptan, propranolol, and topiramate." | 3.88 | Soluble guanylyl cyclase is a critical regulator of migraine-associated pain. ( Ben Aissa, M; Bennett, BM; Bertels, Z; Gaisina, IN; Gandhi, R; Lee, SH; Litosh, V; Moye, LS; Novack, M; Pradhan, AA; Thatcher, GR; Tipton, AF; Wang, Y, 2018) |
| "Systemic administration of nitroglycerin (NTG) consistently provokes spontaneous-like migraine attacks in migraine sufferers, and in rat it induces hyperalgesia and allodynia." | 3.83 | Ghrelin attenuates hyperalgesia and light aversion-induced by nitroglycerin in male rats. ( Babri, S; Farajdokht, F; Karimi, P; Mohaddes, G, 2016) |
| "The NO donors nitroglycerin and sodium nitroprusside (SNP) induced allodynia (cold plate test) and hyperalgesia (hot plate test)." | 3.79 | St. John's wort relieves pain in an animal model of migraine. ( Galeotti, N; Ghelardini, C, 2013) |
| "In migraineurs nitroglycerin (NTG) induces severe delayed headache, resembling spontaneous migraine attacks." | 3.72 | Nitroglycerin induces migraine headache and central sensitization phenomena in patients with migraine without aura: a study of laser evoked potentials. ( Cerbo, R; de Tommaso, M; Difruscolo, O; Guido, M; Libro, G; Losito, L; Sardaro, M, 2004) |
| "two types of headache developed after the nitroglycerin administration: (1) an immediate headache that does not fulfil the criteria for migraine, mild and disappears spontaneously within 1 hour; (2) a typical migraine attack without aura develops several hours after the nitroglycerin administration (mean latency: 250 min), moderate or severe, and warrants antimigraine therapy." | 3.72 | [Nitroglycerin-induced headaches]. ( Bagdy, G; Gonda, X; Juhász, G; Zsombók, T, 2004) |
| "Fifty-three patients with migraine were enrolled; imaging on at least one triggered visit was obtained from 25 patients, with 21 patients completing the entire imaging protocol including a placebo visit." | 3.30 | Regional cerebral perfusion during the premonitory phase of triggered migraine: A double-blind randomized placebo-controlled functional imaging study using pseudo-continuous arterial spin labeling. ( Bose, RP; Goadsby, PJ; Karsan, N; O'Daly, O; Zelaya, F, 2023) |
| "Nitroglycerin is a potent, reliable and reproducible migraine trigger of the entirety of the migraine attack, making its use experimentally attractive." | 2.94 | Headache and non-headache symptoms provoked by nitroglycerin in migraineurs: A human pharmacological triggering study. ( Bose, PR; Goadsby, PJ; Karsan, N; Newman, J; Thompson, C, 2020) |
| "Subjects aged 18-50 years with migraine with and without aura (≤22 headache days per month) were recruited from across the UK using advertising, from both population and hospital clinic samples (n = 53)." | 2.94 | Alterations in Functional Connectivity During Different Phases of the Triggered Migraine Attack. ( Bose, PR; Goadsby, PJ; Karsan, N; O'Daly, O; Zelaya, FO, 2020) |
| "Cranial allodynia associated with spontaneous migraine is reported as either responsive to triptan treatment or to be predictive of lack of triptan efficacy." | 2.90 | Nitroglycerine triggers triptan-responsive cranial allodynia and trigeminal neuronal hypersensitivity. ( Akerman, S; Bose, P; Goadsby, PJ; Hoffmann, JR; Holland, PR; Karsan, N; Romero-Reyes, M, 2019) |
| "Nitroglycerin (NTG)-induced migraine-type headache is the most prominent side effect of nitrate therapy." | 2.87 | Effect of applying reflexology massage on nitroglycerin-induced migraine-type headache: A placebo-controlled clinical trial. ( Ghavami, H; Imani, N; Khalkhali, HR; Radfar, M; Shams, SA, 2018) |
| "Provoking delayed migraine with nitroglycerin in migraine sufferers is a cumbersome model." | 2.75 | Nitroglycerin provocation in normal subjects is not a useful human migraine model? ( Iversen, HK; Olesen, J; Tfelt-Hansen, P; Tvedskov, JF, 2010) |
| "In a double-blind-cross-over study, 13 migraine without aura (MO) patients were administered GTN 0." | 2.75 | CGRP receptor antagonist olcegepant (BIBN4096BS) does not prevent glyceryl trinitrate-induced migraine. ( Jensen, LT; Olesen, J; Petersen, KA; Tfelt-Hansen, P; Tvedskov, JF, 2010) |
| "Sumatriptan was rapidly absorbed after intranasal administration using the new device." | 2.74 | Rapid absorption of sumatriptan powder and effects on glyceryl trinitrate model of headache following intranasal delivery using a novel bi-directional device. ( Boeijinga, P; Danjou, P; Demazières, A; Djupesland, PG; Flint, A; Hewson, G; Luthringer, R; Sheldrake, CD, 2009) |
| "It has been known that in a migraine attack intracranial and extracranial arteries on the headache side dilate and when the migraine attack has subsided, the intracranial arteries show segmental narrowing." | 2.73 | Increased dilator response to nitrate and decreased flow-mediated dilatation in migraineurs. ( Aksoy, Y; Ozcan, C; Ozisik, H; Turhan, H; Yetkin, E, 2007) |
| "During migraine, blood vessel diameters were no different from baseline, nor between headache and non-headache sides." | 2.73 | Migraine headache is not associated with cerebral or meningeal vasodilatation--a 3T magnetic resonance angiography study. ( Ferrari, MD; Kortmann, C; Schoonman, GG; Terwindt, GM; van der Geest, RJ; van der Grond, J, 2008) |
| "The need for experimental migraine models increases as therapeutic options widen." | 2.71 | A double-blind study of SB-220453 (Tonerbasat) in the glyceryltrinitrate (GTN) model of migraine. ( Iversen, HK; Olesen, J; Tvedskov, JF, 2004) |
| "Forty-two patients with migraine without aura underwent the test before and 2 months after antimigraine therapy." | 2.69 | Long-term outcome of migraine therapy: predictive value of the frontotemporal nitroglycerin test. ( Amato, D; Bonuso, S; Caruso, G; de Angelis, S; Di Stasio, E; Marano, E; Scellini, T, 1998) |
| "We have compared the migraine-inducing effect of nitroglycerin ointment applied to the frontotemporal region of the head, which is innervated by the ophthalmic and maxillary divisions of the trigeminal nerve, with that of nitroglycerin applied to the chin (innervated by the mandibular division), the posterolateral region of the neck (innervated by the second and third cervical roots), the lateral surface of the proximal third of the forearm (innervated by the sixth cervical root), and the medial surface of the upper-arm region (second dorsal root)." | 2.68 | The frontotemporal region plays a role in the genesis of migraine without aura. ( Bonuso, S; Di Stasio, E; Marano, E; Sorge, F; Testa, N; Tetto, A, 1995) |
| "It has previously been shown that in migraine sufferers infusion of glyceryl trinitrate (GTN) and histamine causes an immediate headache during the infusion and a genuine migraine attack one to several hours after the infusion." | 2.68 | Histamine-1 receptor blockade does not prevent nitroglycerin induced migraine. Support for the NO-hypothesis of migraine. ( Iversen, HK; Kruuse, C; Lassen, LH; Olesen, J; Thomsen, LL, 1996) |
| "Twenty common migraine patients received a one sided frontotemporal application of nitroglycerin (10 patients) or placebo ointment (10 patients) in a double blind study." | 2.66 | Source of pain and primitive dysfunction in migraine: an identical site? ( Barbieri, F; Bonuso, S; di Stasio, E; Marano, E; Sorge, F; Ullucci, EA, 1989) |
| "Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models." | 2.61 | Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back. ( Borsook, D; De Icco, R; Demartini, C; Greco, R; Sances, G; Tassorelli, C; Zanaboni, AM, 2019) |
| "Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation." | 2.58 | Migraine and cluster headache - the common link. ( Ashina, M; Benemei, S; Cortese, F; Labastida-Ramírez, A; Lampl, C; Marchese, F; Pellesi, L; Romoli, M; Vollesen, AL, 2018) |
| "In the paper, by taking acupuncture and migraine as the key words to retrieve CNKI and PubMed database, the literature analysis was done on the mechanism study on experimental migraine treated with acupuncture in rat model." | 2.53 | [Progression of the mechanism study on experimental migraine treated with acupuncture in rat model]. ( Liu, L; Pei, P; Wang, L, 2016) |
| "Given the nature of migraine attacks, fully reversible and treatable, the headache- or migraine-provoking property of naturally occurring signaling molecules can be tested in a human model." | 2.49 | Pearls and pitfalls in human pharmacological models of migraine: 30 years' experience. ( Ashina, M; Hansen, JM; Olesen, J, 2013) |
| "Familiar hemiplegic migraine patients seem to be less sensitive to GTN and CGRP provocation compared with common types of migraine." | 2.46 | What have we learnt from triggering migraine? ( Ashina, M; Schoonman, GG; Schytz, HW, 2010) |
| "Human models of migraine attacks are indispensable tools in pathophysiological and therapeutic research." | 2.44 | Evaluation and proposal for optimization of neurophysiological tests in migraine: part 2--neuroimaging and the nitroglycerin test. ( Afridi, S; Bendtsen, L; Goadsby, PJ; Kaube, H; Magis, D; May, A; Sánchez del Rio, M; Sandór, PS; Sandrini, G; Schoenen, J; Schoonman, GG, 2007) |
| "Animal models for migraine have provided substantial advances on the mechanisms and mediators underlying migraine attacks." | 2.42 | Peripheral and central activation of trigeminal pain pathways in migraine: data from experimental animal models. ( Buzzi, MG; Nappi, G; Tassorelli, C, 2003) |
| "As the molecular mechanism of migraine pain remains to be determined, NTG, being pro-drug for NO, has been used to study the aetiology and pathophysiology of migraine." | 2.42 | The role of nitric oxide in vascular headache. ( Lohman, JJ; van der Kuy, PH, 2003) |
| "In an animal model of migraine, we have recently shown that chemical activation of meningeal primary afferent nociceptors that innervate the dura could lead to the following: a) peripheral sensitization of these nociceptors to intracranial mechanical stimulation; b) central sensitization of second-order trigeminovascular neurons that receive convergent input from the dura and skin to extracranial mechanical and thermal stimulation; and c) facilitated cardiovascular pressor responses that are usually indicative of pain." | 2.41 | Peripheral and central sensitization during migraine. ( Burstein, R; Malick, A, 2000) |
| "However, the pathophysiology of migraine remains unsolved, why results from animal studies not directly can be related to the migraine attack, which is a human experience." | 2.41 | Human migraine models. ( Iversen, HK, 2001) |
| "The molecular mechanisms of migraine pain have not yet been clarified." | 2.40 | Nitric oxide theory of migraine. ( Olesen, J; Thomsen, LL, 1998) |
| "A chronic migraine model was established in mice by repeated injection of nitroglycerin (10 mg/kg, i." | 1.91 | Roxadustat alleviates nitroglycerin-induced migraine in mice by regulating HIF-1α/NF-κB/inflammation pathway. ( Chen, YL; Duan, YJ; Fan, XD; Gao, YY; Han, JH; Liao, CZ; Meng, XS; Sun, L; Wang, XR; Xie, ZL; Yang, DG; Yang, XX; Yin, ZQ; Zou, TF, 2023) |
| "Migraine is a recurrent primary headache disorder with moderate to severe disability; however, the pathophysiology is not fully understood." | 1.91 | Multi-region local field potential signatures and brain coherence alternations in response to nitroglycerin-induced migraine attacks. ( Lin, Q; Peng, YB; Wang, Z, 2023) |
| "In the acute migraine model, rats received CBD (15 mg or 30 mg/kg, i." | 1.91 | Characterization of the biochemical and behavioral effects of cannabidiol: implications for migraine. ( Demartini, C; Facchetti, S; Francavilla, M; Franco, V; Greco, R; Pacchetti, B; Palmisani, M; Sodergren, MH; Tassorelli, C; Zanaboni, AM, 2023) |
| "Chronic migraine (CM) is a common neurological disorder with complex pathogenesis." | 1.91 | PACAP6-38 improves nitroglycerin-induced central sensitization by modulating synaptic plasticity at the trigeminal nucleus caudalis in a male rat model of chronic migraine. ( Wang, Y; Xiao, Z; Yang, L; Zhang, L; Zhou, Y, 2023) |
| "In the nitroglycerin-induced chronic migraine model, the microglial response to extracellular stimuli leads to the activation of surface purine receptors P2X4、P2X7、P2Y12, which mediate signal transduction through intracellular signalling cascades, such as the BDNF/TrkB, NLRP3/IL-1β and RhoA/ROCK signalling pathways, and release inflammatory mediators and cytokines that enhance pain by increasing the excitability of nearby neurons." | 1.91 | The status of knowledge on migraines: The role of microglia. ( He, W; Wang, Y; Zhang, Y; Zhou, J, 2023) |
| "The mechanism of SGD in remedying migraine was studied through transcriptome sequencing (RNA-seq), which was further validated utilizing Elisa, Reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blotting (WB) experiments." | 1.91 | Shaoyao Gancao decoction alleviates the central hyperalgesia of recurrent NTG-induced migraine in rats by regulating the NGF/TRPV1/COX-2 signal pathway. ( Hou, J; Ji, X; Li, R; Liu, Z; Luo, Y; Qiu, Y; Song, H; Tao, X; Wang, T; Yang, F; Zhang, S; Zhang, Y; Zhou, R, 2023) |
| "Sumatriptan acts as a synergist of the NTG vasodilating action." | 1.91 | Duality in response of intracranial vessels to nitroglycerin revealed in rats by imaging photoplethysmography. ( Iurkova, PM; Kamshilin, AA; Nippolainen, E; Potapenko, AV; Sokolov, AY; Volynsky, MA; Zaytsev, VV, 2023) |
| "The pathophysiological mechanisms of migraine remain controversial." | 1.91 | Aryl hydrocarbon receptors improve migraine-like pain behaviors in rats through the regulation of regulatory T cell/T-helper 17 cell-related homeostasis. ( Wang, Y; Xiao, Z; Yang, L; Zhang, L; Zhang, Y; Zhou, Y, 2023) |
| "Due to its widespread prevalence, migraine is a common neurovascular condition that has a major impact on people's health and quality of life." | 1.91 | Rutaecarpine alleviates migraine in nitroglycerin-induced mice by regulating PTEN/PGK1 signaling pathway to activate NRF2 antioxidant system. ( Gong, M; He, Z; Ling, X; Liu, H; Shi, Z; Wang, W; Xu, M, 2023) |
| "A mouse model of chronic migraine (CM) was established by repeated nitroglycerin (NTG) stimulation and evaluated by von-Frey filaments, a hot plate and a light-dark box." | 1.91 | Proteomics profiling reveals mitochondrial damage in the thalamus in a mouse model of chronic migraine. ( Gong, Z; Li, B; Li, C; Li, R; Ma, Z; Miao, S; Tang, W; Wang, T; Xie, W; Yang, C; Yu, S; Zhou, Y, 2023) |
| " In vivo pharmacokinetic study demonstrated improved brain bioavailability of SUT-NEsG as compared to orally administered sumatriptan solution (SUT-SL)." | 1.91 | Quality by design for sumatriptan loaded nano-ethosomal mucoadhesive gel for the therapeutic management of nitroglycerin induced migraine. ( Alharbi, HM; Almari, AH; Batool, S; Din, FU; Fatease, AA; Lahiq, AA; Shafique, U; Sohail, S, 2023) |
| "Nitroglycerin-induced hyperalgesia was evaluated in mice with different gut microbiota statuses as follows: Specific pathogen-free mice; germ-free mice; specific pathogen-free mice treated with antibiotics to deplete the gut microbiome (ABX mice); and germ-free mice transplanted with the gut microbial profile from specific pathogen-free mice (GFC mice)." | 1.72 | The gut microbiome modulates nitroglycerin-induced migraine-related hyperalgesia in mice. ( Kang, L; Kong, S; Li, Y; Liu, J; Tang, W; Yu, S; Zhang, M; Zhang, Y; Zhao, D, 2022) |
| "Chronic migraine places a disabling burden on patients, which is extensively modeled by the nitroglycerin (NTG)-treated animal model." | 1.72 | IL-17 crosses the blood-brain barrier to trigger neuroinflammation: a novel mechanism in nitroglycerin-induced chronic migraine. ( Chen, H; Hu, B; Li, J; Ma, T; Tang, X; Xu, S; Yang, W; Zhan, M, 2022) |
| "Nitroglycerin (NTG) was used to establish a mouse migraine model, and a behaviour study was conducted by hot plate test." | 1.72 | Classical prescription Dachuanxiong Formula delays nitroglycerin-induced pain response in migraine mice through reducing endothelin-1 level and regulating fatty acid biosynthesis. ( Chen, Y; Chen, Z; Gao, C; Vong, CT; Wang, S; Wang, Y; Yang, F, 2022) |
| "Contrary to previous results with the migraine-inducing substances glyceryl trinitrate, cilostazol and levcromakalim, PACAP-38-induced hypersensitivity worked only partially through inhibition of ATP-sensitive potassium channels." | 1.72 | The PACAP pathway is independent of CGRP in mouse models of migraine: possible new drug target? ( Christensen, SL; Ernstsen, C; Jansen-Olesen, I; Kristensen, DM; Nielsen, BS; Olesen, J; Rasmussen, RH, 2022) |
| "Interestingly, these migraine-associated single-nucleotide polymorphisms reside in noncoding regions of TRPM8, with those correlated with reduced migraine risk exhibiting lower TRPM8 expression and decreased cold sensitivity." | 1.72 | Transient receptor potential melastatin 8 is required for nitroglycerin- and calcitonin gene-related peptide-induced migraine-like pain behaviors in mice. ( Kim, B; McKemy, DD; Wei, C, 2022) |
| "Converging evidence shows that migraine is associated with gastrointestinal disorders." | 1.72 | Supplementation with SCFAs Re-Establishes Microbiota Composition and Attenuates Hyperalgesia and Pain in a Mouse Model of NTG-Induced Migraine. ( Campolo, M; Casili, G; Cuzzocrea, S; Esposito, E; Filippone, A; Giuffrè, L; Lanza, M; Paterniti, I; Scuderi, SA, 2022) |
| "The mechanism of SPD in treating migraine was studied through network pharmacology, which was further verified using pharmacological experiments." | 1.72 | San Pian decoction can treat nitroglycerin-induced migraine in rats by inhibiting the PI3K/AKT and MAPK signaling pathways. ( Cui, Y; Du, H; Feng, Y; Mao, Q; Ouyang, H; Wu, J; Yang, S; Zhou, M, 2022) |
| "Migraine is a complex neurovascular disorder characterized by recurrent attacks of pain and other associated symptoms." | 1.72 | Modelling migraine-related features in the nitroglycerin animal model: Trigeminal hyperalgesia is associated with affective status and motor behavior. ( Demartini, C; Francavilla, M; Greco, R; Tassorelli, C; Zanaboni, AM, 2022) |
| "We established a mouse model of chronic migraine with intermittent injections of clinically-relevant dose of nitroglycerin (0." | 1.72 | CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine. ( Chen, SP; Chou, TM; Lee, ZF; Lien, CC; Wang, SJ, 2022) |
| "The effects of exogenous HSP70 on migraine-like symptoms were assessed through behavioral assays." | 1.62 | Exogenous Hsp70 attenuates nitroglycerin-induced migraine-like symptoms in mice. ( Huang, Y; Huang, Z; Liao, J; Lin, W; Shi, C; Wei, G; Wu, F, 2021) |
| "Migraine is caused by hyperactivity of the trigeminovascular system, where trigeminal ganglia (TG) play an important role." | 1.62 | α6GABA ( Chiou, LC; Cook, J; Fan, PC; Knutson, DE; Lai, TH; Lee, MT; Sieghart, W; Tzeng, HR, 2021) |
| "Nitroglycerin induced activation of migraine-like central trigeminocervical neurons, and intracranial and extracranial neuronal hypersensitivity." | 1.62 | Therapeutic targeting of nitroglycerin-mediated trigeminovascular neuronal hypersensitivity predicts clinical outcomes of migraine abortives. ( Akerman, S; Bose, P; Goadsby, PJ; Hoffmann, JR; Holland, PR; Karsan, N; Romero-Reyes, M, 2021) |
| "With a prevalence of 15%, migraine is the most common neurological disorder and among the most disabling diseases, taking into account years lived with disability." | 1.62 | Double-Binding Botulinum Molecule with Reduced Muscle Paralysis: Evaluation in In Vitro and In Vivo Models of Migraine. ( Andreou, AP; Corrie, E; Davletov, B; Demartini, C; Doran, C; Gafurov, O; Giniatullin, R; Greco, R; Koroleva, K; Lambru, G; Leese, C; Lloyd, JO; Seward, E; Simsek, D; Tassorelli, C; Zanaboni, A, 2021) |
| "This study shows that the antimigraine effects of DOR agonists can be separated from their proconvulsant effects." | 1.62 | A non-convulsant delta-opioid receptor agonist, KNT-127, reduces cortical spreading depression and nitroglycerin-induced allodynia. ( Asif, S; Bertels, Z; Pradhan, AA; Siegersma, K; van Rijn, RM; Witkowski, WD, 2021) |
| "Non-painful symptoms in migraine following headache resolution can last up to days." | 1.62 | The migraine postdrome: Spontaneous and triggered phenotypes. ( Bose, PR; Goadsby, PJ; Karsan, N; Nagaraj, K; Peréz-Rodríguez, A, 2021) |
| "Twenty-four subjects with episodic migraine (MIG) and 19 healthy controls (HC) underwent blood sampling and investigation of nociceptive withdrawal reflex thresholds (RTh: single-stimulus threshold; TST: temporal summation threshold) before and 30 (T30), 60 (T60), and 120 (T120) minutes after sublingual NTG administration (0." | 1.62 | Spinal nociceptive sensitization and plasma palmitoylethanolamide levels during experimentally induced migraine attacks. ( Allena, M; De Icco, R; Demartini, C; Greco, R; Grillo, V; Realini, N; Reggiani, A; Sances, G; Tassorelli, C; Tumelero, E; Vergobbi, P; Zanaboni, A, 2021) |
| "We use validated mouse models of migraine to show that HDAC6-inhibition is a promising migraine treatment and reveal an undiscovered cytoarchitectural basis for migraine chronicity." | 1.62 | Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition. ( Ao, M; Baca, SM; Bertels, Z; Conway, C; Dripps, I; Karumudi, B; Mangutov, E; Petukhov, PA; Petukhova, V; Pradhan, AA; Rasenick, MM; Shah, P; Sheets, Z; Siegersma, K; Singh, H; Tipton, AF; Witkowski, WD, 2021) |
| "Migraine is one of the most common neurological disorders characterized by recurrent attacks of typically throbbing and unilateral headaches, affecting up to 20% of the population worldwide." | 1.62 | Protein kinase Cδ as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice. ( He, Y; Kashyap, Y; Messing, RO; Shi, Z; Wang, ZJ, 2021) |
| "Additionally, five migraineurs were investigated in a spontaneous premonitory phase." | 1.62 | Hypothalamic functional MRI activity in the initiation phase of spontaneous and glyceryl trinitrate-induced migraine attacks. ( Ferrari, MD; Kruit, MC; Schoonman, GG; Terwindt, GM; van der Grond, J; van Oosterhout, WPJ; van Opstal, AM, 2021) |
| "In 16 women with migraine without aura and 10 age- and gender-matched controls without headache, intravenous nitroglycerin (0." | 1.56 | Abnormal cardiovascular response to nitroglycerin in migraine. ( Ferrari, MD; Saal, DP; Schoonman, GG; Thijs, RD; van Dijk, JG; van Oosterhout, WP, 2020) |
| "However, the role of PD-L1/PD-1 in migraine remains unclear." | 1.56 | PD-L1 and PD-1 expressed in trigeminal ganglia may inhibit pain in an acute migraine model. ( Guo, P; Han, Y; Ren, T; Shi, S; Wang, D; Wang, J; Wang, W, 2020) |
| "The present first-line anti-migraine medications can cause overwhelming side-effects, of which one includes the onset of cardiovascular disease." | 1.56 | Tibetan medicine Ru-yi-Zhen-bao Pills exhibits anti-migraine effect through mediating PAG anti-nociceptive channel. ( Dong, RJ; Gao, MH; Ge, DY; Li, R; Li, YR; Luo, YM; Ma, L; Ren, QJ; Ren, XQ; Song, HR; Tao, XH; Wang, CG; Yang, XQ; Zhang, SJ; Zhou, RR, 2020) |
| "5-BDBD or ANA-12 prevented hyperalgesia induced by NTG, which was associated with a significant inhibition of the NTG-induced increase in phosphorylated extracellular regulated protein kinases (p-ERK) and calcitonin gene related peptide (CGRP) release in the TNC." | 1.56 | Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model. ( Chen, L; He, W; Long, T; Pan, Q; Qin, G; Zhang, D; Zhang, S; Zhou, J, 2020) |
| "Headache disorders are highly prevalent and debilitating, with limited treatment options." | 1.56 | Low-dose interleukin-2 reverses behavioral sensitization in multiple mouse models of headache disorders. ( Cao, YQ; Cloud, ME; Czerpaniak, K; Hotchkiss, RS; Huang, L; Li, D; Liu, X; Unsinger, J; Zhang, J, 2020) |
| "Evodiamine (EVO) is a natural compound derived from Tetradium ruticarpum (A." | 1.56 | Evodiamine via targeting nNOS and AMPA receptor GluA1 inhibits nitroglycerin-induced migraine-like response. ( Chen, J; Li, C; Li, Z; Lin, J; Lu, H; Wu, Z; Yang, X; Zhang, X; Zhang, Y, 2020) |
| "Throbbing pain is one of several migraine symptoms including sensitivity to light (photophobia), sometimes to sounds, smell and touch." | 1.56 | NOP receptor agonist attenuates nitroglycerin-induced migraine-like symptoms in mice. ( Bertels, Z; Cippitelli, A; Kieffer, BL; Marcus, JL; Mielke-Maday, HK; Ozawa, A; Pradhan, AA; Rainey, AN; Targowska-Duda, KM; Toll, L; Zribi, G, 2020) |
| "In women with migraine without aura (n = 34) and age-matched female controls (n = 24), we conducted systematically a semistructured interview assessing 21 possible premonitory symptoms every 15 minutes in the 5 hours after GTN infusion (0." | 1.56 | Premonitory symptoms in glyceryl trinitrate triggered migraine attacks: a case-control study. ( Dool, J; Ferrari, MD; Onderwater, GLJ; Terwindt, GM, 2020) |
| "Many patients with chronic migraine are difficult to treat." | 1.56 | Chronic Migraine With Apparent Loss of Response to Onabotulinum Toxin Type A Due to Local Nitroglycerin Treatment for an Anal Fissure: A Case Report. ( González-Quintanilla, V; Madera, J; Pascual, J; Pérez-Pereda, S, 2020) |
| "Migraine is commonly reported among patients with temporomandibular disorders (TMDs), especially myogenic TMD." | 1.56 | A Pre-Existing Myogenic Temporomandibular Disorder Increases Trigeminal Calcitonin Gene-Related Peptide and Enhances Nitroglycerin-Induced Hypersensitivity in Mice. ( Bellinger, LL; Bender, SD; Dolan, JC; Kramer, PR; Liu, S; Schmidt, BL; Shu, H; Tang, Y; Tao, F, 2020) |
| "CM led to persistent thermal hyperalgesia, spontaneous facial pain, and prominent vestibular dysfunction, accompanied by the upregulation of c-fos labeling neurons and CGRP immunoreactivity in the TNC (c-fos: vehicle vs." | 1.56 | Calcitonin gene-related peptide facilitates sensitization of the vestibular nucleus in a rat model of chronic migraine. ( Chen, L; Fan, X; Pan, Q; Qin, G; Tian, K; Wang, Y; Zhang, D; Zhang, Y; Zhou, J, 2020) |
| "To verify the anti-migraine effect of wine-processed RS in nitroglycerin (NTG)-induced rats and explore the correlation between compounds dissolution and the pore structure based on fractal theory." | 1.56 | Anti-migraine effect of wine-processed Radix scutellariae: Pharmacodynamic verification in nitroglycerin-induced rats and correlation study between compounds dissolution and the fractal dimension. ( Chen, QJ; Lu, F; Sun, YW; Wang, CZ; Yang, XL; Yuan, CS; Zhai, S; Zhang, CF; Zhang, WJ, 2020) |
| "To model chronic migraine-associated pain, nitroglycerin (NTG) (5 mg/kg/IP) was administered to test subjects every second day for 9 days." | 1.56 | Activation orexin 1 receptors in the ventrolateral periaqueductal gray matter attenuate nitroglycerin-induced migraine attacks and calcitonin gene related peptide up-regulation in trigeminal nucleus caudalis of rats. ( Abbasnejad, M; Esmaeili-Mahani, S; Kooshki, R; Raoof, M; Sheibani, V, 2020) |
| "In a model of chronic migraine-associated pain using the human migraine trigger, nitroglycerin, we observed increased expression of DOR in cortex, hippocampus, and striatum; suggesting a role for these forebrain regions in the regulation of migraine." | 1.56 | Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia. ( Baca, SM; Bertels, Z; Dripps, IJ; Kieffer, BL; Moye, LS; Pradhan, AA; Siegersma, K; Tipton, AF, 2020) |
| "Furthermore, NTG-induced migraine-like pain in GF mice was markedly enhanced compared to that in WT mice and gut colonization with fecal microbiota from WT mice robustly reversed microbiota deprivation-caused pain enhancement." | 1.56 | Gut Microbiota Dysbiosis Enhances Migraine-Like Pain Via TNFα Upregulation. ( Liu, S; Shu, H; Tang, Y; Tao, F; Yanagisawa, L, 2020) |
| "The pathogenesis of medication overuse headache (MOH) involves hyperexcitability of cortical and trigeminal neurons." | 1.51 | Altered activity in the nucleus raphe magnus underlies cortical hyperexcitability and facilitates trigeminal nociception in a rat model of medication overuse headache. ( le Grand, SM; Potewiratnanond, P; Srikiatkhachorn, A; Supronsinchai, W, 2019) |
| "Nociceptors from migraine patients with the F139WfsX2 mutation show loss of functional TRESK at the membrane, with a corresponding significant increase in neuronal excitability." | 1.51 | A causal role for TRESK loss of function in migraine mechanisms. ( Arunasalam, K; Bassett, A; Cader, MZ; Cheung, J; Chintawar, S; Couper, E; Cowley, SA; Duggal, G; Flower, G; Griffiths, LR; Handel, A; Haupt, LM; Lalic, T; Pettingill, P; Wei, T; Weir, GA; Wu, Y, 2019) |
| "A nitroglycerin-induced migraine model in rats and a reserpine-induced migraine model in mice were established to investigate the effects of RCXTAs on monoamine neurotransmitters in brain tissue, including 5-hydroxytryptamine (5-HT) and its metabolite (5-HIAA)." | 1.51 | Alkaloids from the rhizomes of Ligusticum striatum exert antimigraine effects through regulating 5-HT ( Feng, R; Luo, M; Peng, C; Pu, ZH; Xie, XF; Xiong, L; Zhu, H, 2019) |
| "Pretreatment with PL ameliorated migraine headache behaviors in the NTG-induced migraine rat model, suggesting pretreatment with PL is beneficial for migraine headache treatment." | 1.51 | Effect of Paeonia lactiflora, a traditional Chinese herb, on migraines based on clinical application and animal behavior analyses. ( Chen, CH; Hsieh, CL; Li, JM; Liao, CC; Lin, CL, 2019) |
| "Background A common characteristic of migraine-inducing substances is that they cause headache and no pain in other areas of the body." | 1.48 | Selective cephalic upregulation of p-ERK, CamKII and p-CREB in response to glyceryl trinitrate infusion. ( Amrutkar, DV; Hay-Schmidt, A; Jacobsen, JM; Jansen-Olesen, I; Olesen, J; Pedersen, SH; Petersen, S; Ramachandran, R, 2018) |
| "Migraine is a common disease with a high morbidity." | 1.48 | Valproate Plays a Protective Role against Migraine by Inhibiting Protein Kinase C Signalling in Nitroglycerin-treated Mice. ( Chen, N; Song, G; Wang, C; Wu, Q; Yi, L; Zhang, Z; Zou, Q, 2018) |
| "By contrast, cold allodynia, but not mechanical hypersensitivity, occurred in the facial region." | 1.48 | Differential Development of Facial and Hind Paw Allodynia in a Nitroglycerin-Induced Mouse Model of Chronic Migraine: Role of Capsaicin Sensitive Primary Afferents. ( Beitz, AJ; Kim, SJ; Kwon, SG; Lee, JH; Roh, DH; Yeo, JH; Yoon, SY, 2018) |
| "The NTG injection induced acute migraine-like pain including photophobia and mechanical hypersensitivity as reported previously." | 1.48 | AMPA receptor GluA1 Ser831 phosphorylation is critical for nitroglycerin-induced migraine-like pain. ( Liu, S; Shu, H; Tang, Y; Tao, F; Xing, Y, 2018) |
| "Chronic migraine dramatically affects the quality of life in the migraineurs." | 1.48 | Cerebrolysin attenuates hyperalgesia, photophobia, and neuroinflammation in a nitroglycerin-induced migraine model in rats. ( Erfani, M; Farajdokht, F; Karimi, P; Mahmoudi, J; Mohaddes, G; Rajabi, M; Reyhani-Rad, S; Sadigh-Eteghad, S, 2018) |
| "Curcumin has antioxidative properties that could be useful in various diseases due to its ability to act on multiple targets of various cellular pathways." | 1.48 | The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats. ( Bolboacă, SD; Bulboacă, AC; Bulboacă, AE; Porfire, A; Sfrângeu, CA; Stănescu, IC; Tefas, L, 2018) |
| "Glyceryl trinitrate causes prolonged mechanical allodynia in rodents, which temporally correlates with delayed glyceryl trinitrate-evoked migraine attacks in patients." | 1.48 | TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice. ( Benemei, S; Bunnett, NW; De Carvalho Goncalves, M; De Logu, F; Ferreira, J; Geppetti, P; Jain, P; Li Puma, S; Marone, IM; Materazzi, S; Nassini, R, 2018) |
| "The mechanism underlying migraine chronification remains unclear." | 1.48 | Microglia P2X4 receptor contributes to central sensitization following recurrent nitroglycerin stimulation. ( Chen, L; He, W; Liu, C; Liu, Q; Long, T; Pan, Q; Qin, G; Zhang, S; Zhang, Y; Zhou, J, 2018) |
| "BAI could alleviate the migraine-like headache induced by NTG, which is related to the regulation of vasoactive substances." | 1.46 | Analgesia effect of baicalein against NTG-induced migraine in rats. ( Bao, Y; Dong, CL; Guo, CR; Hu, WL; Sun, YY; Wang, CZ; Yuan, CS; Zhang, CF; Zhang, WJ; Zhang, XF, 2017) |
| "Chronic migraine is a common debilitating disease with limited treatment options." | 1.46 | Nitroglycerin challenge induces lateralized headache in nasociliarynerve-ligated rats: implications for chronic migraine. ( Akçali, D; Babacan, A; Belen, AD; Bolay, H, 2017) |
| "The presentation of spontaneous tactile allodynia was observed in the nitroglycerin group by the 5th episode." | 1.46 | The effects of repeated nitroglycerin administrations in rats; modeling migraine-related endpoints and chronification. ( Black, JR; Carpenter, JM; Harris, HM; Smitherman, TA; Sufka, KJ, 2017) |
| "Migraine is a common neurological disorder with a serious impact on quality of life." | 1.46 | Baicalin Alleviates Nitroglycerin-induced Migraine in Rats via the Trigeminovascular System. ( Cui, CL; Dong, CL; Du, WJ; Hu, WL; Ji, J; Li, F; Sun, YY; Wang, CZ; Wang, L; Wang, X; Yuan, CS; Zhang, CF; Zhang, WJ; Zhang, XF, 2017) |
| " In addition, chronic administration of nitroglycerin produces a progressive and sustained decrease in basal mechanical responses, and this hypersensitivity is blocked by migraine preventatives such as topiramate." | 1.46 | Animal Model of Chronic Migraine-Associated Pain. ( Moye, LS; Pradhan, AAA, 2017) |
| "In rats bearing nitroglycerin-induced hyperalgesia, ADM_12 showed an anti-hyperalgesic effect in the second phase of the orofacial formalin test." | 1.46 | The role of the transient receptor potential ankyrin type-1 (TRPA1) channel in migraine pain: evaluation in an animal model. ( Demartini, C; Francesconi, O; Greco, R; Nativi, C; Tassorelli, C; Tonsi, G; Zanaboni, AM, 2017) |
| "In the present study, we aimed to elucidate the pharmacodynamic action of DL and its mechanism in an animal model of migraines induced by glyceryl trinitrate (GTN)." | 1.46 | Pharmacodynamic action and mechanism of Du Liang soft capsule, a traditional Chinese medicine capsule, on treating nitroglycerin-induced migraine. ( Chen, L; Hou, M; Liu, Y; Tang, Q; Xu, X; Xue, Q; Yang, S; Zhang, X, 2017) |
| "Chronic migraine is a debilitating disorder that has a significant impact on patients and society." | 1.46 | Chronic ghrelin treatment reduced photophobia and anxiety-like behaviors in nitroglycerin- induced migraine: role of pituitary adenylate cyclase-activating polypeptide. ( Alipour, MR; Babri, S; Bughchechi, R; Farajdokht, F; Karimi, P; Mohaddes, G, 2017) |
| "Results KYNA-A1 abolished NTG-induced hyperalgesia in both pain models; NTG alone or associated to formalin injection induced an increased mRNA expression of CGRP, nNOS and cytokines in the trigeminal ganglia and central areas, which was reduced by KYNA-A1." | 1.46 | Effects of kynurenic acid analogue 1 (KYNA-A1) in nitroglycerin-induced hyperalgesia: Targets and anti-migraine mechanisms. ( Blandini, F; Demartini, C; Fülöp, F; Greco, R; Nappi, G; Pampalone, S; Redavide, E; Sandrini, G; Tassorelli, C; Toldi, J; Vécsei, L; Zanaboni, AM, 2017) |
| "The complex pathophysiology of migraine is not yet clearly understood; therefore, experimental models are essential for the investigation of the processes related to migraine headache, which include cortical spreading depression (CSD) and NO donor-induced neurovascular changes." | 1.46 | Nitroglycerin enhances the propagation of cortical spreading depression: comparative studies with sumatriptan and novel kynurenic acid analogues. ( Knapp, L; Kocsis, K; Szita, B; Toldi, J; Vécsei, L, 2017) |
| "One of the human and animal models of migraine is the systemic administration of the nitric oxide donor (NO) nitroglycerin (NTG)." | 1.43 | The modulatory effect of anandamide on nitroglycerin-induced sensitization in the trigeminal system of the rat. ( Bohár, Z; Fejes-Szabó, A; Laborc, KF; Nagy-Grócz, G; Párdutz, Á; Spekker, E; Tar, L; Vécsei, L, 2016) |
| "Background The development of novel migraine therapies has been slow, in part because of the small number of clinically relevant animal models." | 1.43 | The effects of acute and preventive migraine therapies in a mouse model of chronic migraine. ( Charles, A; McGuire, B; Pradhan, AA; Tarash, I; Tipton, AF, 2016) |
| "An optimal therapy for migraine has not yet been developed." | 1.43 | Pharmacological characterization of a novel gastrodin derivative as a potential anti-migraine agent. ( Chen, C; Du, JR; Long, FY; Mao, XN; Wan, JY; Wang, PH; Zhang, L; Zhang, S; Zhao, LX, 2016) |
| "Nitroglycerin (NTG) was employed to induce a migraine model in rats and the migraine animals were exposed to treatment of VPA of different doses." | 1.43 | Valproate ameliorates nitroglycerin-induced migraine in trigeminal nucleus caudalis in rats through inhibition of NF-кB. ( Li, Q; Li, Y; Qi, D; Yi, L; Zhang, L; Zhang, Q; Zhang, Z, 2016) |
| "This binding pattern was identical in migraineurs during glyceryl trinitrate-induced migraine attacks as well as in matched control subjects." | 1.43 | Ictal lack of binding to brain parenchyma suggests integrity of the blood-brain barrier for 11C-dihydroergotamine during glyceryl trinitrate-induced migraine. ( Blecha, J; Chou, DE; Eller, M; Goadsby, PJ; Hawkins, RA; Kori, S; Maniyar, FH; Murphy, ST; Schankin, CJ; Seo, Y; Sprenger, T; VanBrocklin, HF, 2016) |
| "BACKGROUND Migraine is a chronic disease that interferes with life quality and work productivity." | 1.43 | Valproate Attenuates Nitroglycerin-Induced Trigeminovascular Activation by Preserving Mitochondrial Function in a Rat Model of Migraine. ( Chen, N; Li, R; Liu, Y; Song, G; Zhang, Y; Zhang, Z, 2016) |
| "Many migraineurs also display alterations in blink reflexes, known to involve brainstem circuits." | 1.43 | Pharmacology of reflex blinks in the rat: a novel model for headache research. ( Andreou, AP; Jones, MG; McMahon, SB; Spanswick, D, 2016) |
| "Sulforaphane pretreatment significantly increased the nuclear Nrf2, HO1, and NQO1 levels in TNC." | 1.43 | Activation of the nuclear factor E2-related factor 2/anitioxidant response element alleviates the nitroglycerin-induced hyperalgesia in rats. ( Di, W; Fang, Y; Li, Z; Liu, J; Lv, H; Shi, X; Zhang, H, 2016) |
| "Migraine headaches are considered to be associated with increased mitochondrial energy metabolism." | 1.42 | Protective effects of riboflavin and selenium on brain microsomal Ca2+-ATPase and oxidative damage caused by glyceryl trinitrate in a rat headache model. ( Bütün, A; Çelik, Ö; Nazıroğlu, M; Uğuz, AC, 2015) |
| "Although migraine is a common neurological condition, the pathomechanism is not yet fully understood." | 1.42 | Role of phosphorylated extracellular signal-regulated kinase, calcitonin gene-related peptide and cyclooxygenase-2 in experimental rat models of migraine. ( Chen, J; Dong, X; Hu, Y; Jing, L, 2015) |
| "We found that nitroglycerin-induced mechanical allodynia and neuronal activation of the trigeminal nucleus were completely abolished in FAAH-deficient mice." | 1.42 | Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice. ( Markert, A; Nozaki, C; Zimmer, A, 2015) |
| "Chest pain is an alarming symptom; it justifies many visits to the emergency department (ED)." | 1.40 | Chest pain a manifestation of migraine. ( Roldan, CJ, 2014) |
| "This chronic basal hyperalgesia occurred in a dose-dependent fashion and persisted for days after cessation of NTG administration." | 1.40 | Characterization of a novel model of chronic migraine. ( Charles, A; Evans, CJ; McGuire, B; Pradhan, AA; Smith, ML; Tarash, I, 2014) |
| "Migraine is an extraordinarily common brain disorder for which treatment options continue to be limited." | 1.40 | δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice. ( Charles, A; Pradhan, AA; Smith, ML; Zyuzin, J, 2014) |
| "Migraine is a common disabling disorder with a significant genetic component, characterized by severe headache and often accompanied by nausea, vomiting, and light sensitivity." | 1.39 | Casein kinase iδ mutations in familial migraine and advanced sleep phase. ( Bates, EA; Brennan, KC; Charles, AC; Fu, YH; Hallows, WC; Huang, Y; Jones, CR; Lee, HY; Ptáček, LJ; Shapiro, RE; Zyuzin, J, 2013) |
| "The third woman had migraine but the attacks were not associated with HS." | 1.38 | Headache in three new cases of Harlequin syndrome with accompanying pharmacological comparison with migraine. ( Goadsby, PJ; Mathias, CJ; Viana, M, 2012) |
| "To evaluate the analgesic and anti-migraine activities of senkyunolide I from Ligusticum chuanxiong." | 1.37 | Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong. ( Feng, Y; He, CY; Hong, YL; Liang, S; Lin, X; Wang, YH; Xu, DS, 2011) |
| "In contrast to patients with migraine with aura (MA) and migraine without aura (MO), most patients with familial hemiplegic migraine (FHM) do not report migraine-like attacks after pharmacologic provocation with glyceryl trinitrate (GTN), a donor of nitric oxide." | 1.36 | Coexisting typical migraine in familial hemiplegic migraine. ( Ashina, M; Hansen, JM; Olesen, J; Thomsen, LL, 2010) |
| "nitroglycerin induced migraine Twenty Sprague-Dawley rats, 10 male and 10 female, were randomly divided into 2 groups: model group, undergoing subcutaneous injection of nitroglycerin 10 mg/kg once a week for 4 weeks so as to establish migraine model, and control group, undergoing subcutaneous injection of normal saline." | 1.35 | [Relationship between P-type Na+ -K+ -Atpase and migraine: an experimental study with rats]. ( Hu, YM; Xiao, B; Yang, XS; Zhang, CY, 2008) |
| " Although kynurenic acid does not cross the BBB, its precursor, kynurenine, if combined with probenecid, crosses it readily." | 1.34 | Kynurenine in combination with probenecid mitigates the stimulation-induced increase of c-fos immunoreactivity of the rat caudal trigeminal nucleus in an experimental migraine model. ( Chadaide, Z; Fenyo, R; Knyihár-Csillik, E; Krisztin-Péva, B; Mihály, A; Németh, H; Toldi, J; Vécsei, L, 2007) |
| " The present investigation tested the hypothesis of whether kynurenine in combination with systemically administered probenecid protects second-order trigeminal neurons against stimulation arriving via central processes of trigeminal ganglion cells." | 1.34 | Prevention of electrical stimulation-induced increase of c-fos immunoreaction in the caudal trigeminal nucleus by kynurenine combined with probenecid. ( Chadaide, Z; Fenyo, R; Knyihár-Csillik, E; Krisztin-Péva, B; Németh, H; Toldi, J; Vécsei, L, 2007) |
| "In each group, a migraine was induced using a glyceryl trinitrate (GTN) infusion." | 1.33 | A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate. ( Afridi, SK; Frackowiak, RS; Friston, KJ; Goadsby, PJ; Kaube, H; Lee, L; Matharu, MS, 2005) |
| "Migraine was provoked in six (42%) patients by hypoxia, in three (21%) by NTG and in two (14%) by placebo." | 1.33 | Normobaric hypoxia and nitroglycerin as trigger factors for migraine. ( Agosti, RM; Bärtsch, P; Baumgartner, RW; Ferrari, MD; Sándor, PS; Schoonman, GG; Siccoli, M, 2006) |
| "One model of migraine headache is the systemic administration of nitric oxide (NO) donor nitroglycerin (NTG), which triggers a delayed attack without aura in many migraine patients but not in healthy volunteers." | 1.33 | [The modulatory effect of estrogen on the caudal trigeminal nucleus of the rat in an animal model of migraine]. ( Párdutz, A; Schoenen, J; Tajti, J; Varga, H; Vécsei, L, 2006) |
| "Nitroglycerin-induced migraine-like headache has been used as an experimental model of migraine." | 1.32 | Reliability of the nitroglycerin provocative test in the diagnosis of neurovascular headaches. ( Ghiotto, N; Nappi, G; Pucci, E; Sances, G; Sandrini, G; Tassorelli, C, 2004) |
| "Nitroglycerin is a NO donor, which easily crosses the blood brain barrier." | 1.32 | Nitroglycerin enhances cGMP expression in specific neuronal and cerebrovascular structures of the rat brain. ( Blandini, F; Greco, R; Nappi, G; Tassorelli, C, 2004) |
| "Studying attacks of migraine is considerably hampered by its fundamentally episodic nature." | 1.32 | Glyceryl trinitrate triggers premonitory symptoms in migraineurs. ( Afridi, KS; Goadsby, JP; Kaube, H, 2004) |
| "Nitroglycerin was terminated and measurements obtained 30 min later." | 1.31 | Brain blood flow in the nitroglycerin (GTN) model of migraine: measurement using positron emission tomography and transcranial Doppler. ( Bednarczyk, EM; Burch, K; Gona, J; Haka, M; Kassab, MY; Trinidad, K; Wack, DS, 2002) |
| "Fourteen age-matched migraine patients with frequent attacks of migraine without aura (>/=12 attacks/year) and 14 healthy subjects served as controls." | 1.31 | Glyceryl trinitrate induced headache in migraineurs - relation to attack frequency. ( Christiansen, I; Daugaard, D; Lykke Thomsen, L; Olesen, J, 2000) |
| "Since triptans exert their anti-migraine effect by virtue of agonist action on 5-HT(1D/B) receptors, we suggest that these drugs prevent the release of CGRP from perivascular nerve terminals in the dura mater by an action at 5-HT(1D/B) receptors." | 1.31 | Functional immunohistochemistry of neuropeptides and nitric oxide synthase in the nerve fibers of the supratentorial dura mater in an experimental migraine model. ( Chadaide, Z; Csillik, B; Knyihár-Csillik, E; Tajti, J; Vécsei, L, 2001) |
| "After puberty migraine is more prevalent in women." | 1.31 | Effect of systemic nitroglycerin on CGRP and 5-HT afferents to rat caudal spinal trigeminal nucleus and its modulation by estrogen. ( Malgrange, B; Multon, S; Parducz, A; Pardutz, A; Schoenen, J; Vecsei, L, 2002) |
| "The molecular mechanisms of migraine pain remain to be determined." | 1.29 | The nitric oxide hypothesis of migraine and other vascular headaches. ( Lassen, LH; Olesen, IJ; Olesen, J; Thomsen, LL, 1995) |
| "The response was more pronounced in migraine patients at the two higher doses (p < 0." | 1.29 | Arterial supersensitivity to nitric oxide (nitroglycerin) in migraine sufferers. ( Brinck, TA; Iversen, HK; Olesen, J; Thomsen, LL, 1993) |
| "Although in migraineurs a number of studies have been done after nitroglycerin-induced attacks, there is no reported EEG study before and after nitroglycerin-induced sumatriptan-treated attacks." | 1.29 | EEG and topographic frequency analysis in migraine attack before and after sumatriptan infusion. ( Karageorgiou, C; Tagaris, G; Thomaides, T, 1996) |
| "In both these models of ergotism, the directly acting vasodilator nitroglycerine (NTG) effectively relieved the ergotamine-induced arterial contractions." | 1.26 | Nitroglycerin for ergotism. Experimental studies in vitro and in migraine patients and treatment of an overt case. ( Gøthgen, I; Husum, B; Jacobsen, E; Ostergaard, JR; Rasmussen, JP; Tfelt-Hansen, P, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (5.91) | 18.7374 |
| 1990's | 15 (6.33) | 18.2507 |
| 2000's | 46 (19.41) | 29.6817 |
| 2010's | 83 (35.02) | 24.3611 |
| 2020's | 79 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, F | 1 |
| Huang, Y | 2 |
| Wei, G | 1 |
| Huang, Z | 1 |
| Shi, C | 1 |
| Lin, W | 1 |
| Liao, J | 1 |
| Kang, L | 1 |
| Tang, W | 2 |
| Zhang, Y | 16 |
| Zhang, M | 1 |
| Liu, J | 2 |
| Li, Y | 2 |
| Kong, S | 1 |
| Zhao, D | 1 |
| Yu, S | 2 |
| Lanza, M | 3 |
| Filippone, A | 3 |
| Ardizzone, A | 1 |
| Casili, G | 3 |
| Paterniti, I | 3 |
| Esposito, E | 3 |
| Campolo, M | 3 |
| Wen, Q | 2 |
| Wang, Y | 11 |
| Pan, Q | 6 |
| Tian, R | 2 |
| Zhang, D | 7 |
| Qin, G | 8 |
| Zhou, J | 9 |
| Chen, L | 10 |
| Onderwater, GLJ | 2 |
| Wijnen, JP | 1 |
| Najac, C | 1 |
| van Dongen, RM | 1 |
| Ronen, I | 1 |
| Webb, A | 1 |
| Zielman, R | 1 |
| van Zwet, EW | 1 |
| Ferrari, MD | 6 |
| Kan, HE | 1 |
| Kruit, MC | 2 |
| Terwindt, GM | 4 |
| Chen, H | 1 |
| Tang, X | 1 |
| Li, J | 3 |
| Hu, B | 1 |
| Yang, W | 1 |
| Zhan, M | 1 |
| Ma, T | 1 |
| Xu, S | 1 |
| Vong, CT | 1 |
| Chen, Y | 1 |
| Chen, Z | 1 |
| Gao, C | 1 |
| Yang, F | 2 |
| Wang, S | 1 |
| Ernstsen, C | 4 |
| Christensen, SL | 4 |
| Rasmussen, RH | 1 |
| Nielsen, BS | 1 |
| Jansen-Olesen, I | 7 |
| Olesen, J | 23 |
| Kristensen, DM | 4 |
| Wei, C | 1 |
| Kim, B | 1 |
| McKemy, DD | 1 |
| Giuffrè, L | 1 |
| Scuderi, SA | 1 |
| Cuzzocrea, S | 2 |
| Gerasimova, E | 1 |
| Yakovleva, O | 1 |
| Enikeev, D | 1 |
| Bogatova, K | 1 |
| Hermann, A | 1 |
| Giniatullin, R | 3 |
| Sitdikova, G | 1 |
| Bertels, Z | 6 |
| Mangutov, E | 2 |
| Conway, C | 2 |
| Siegersma, K | 4 |
| Asif, S | 2 |
| Shah, P | 2 |
| Huck, N | 1 |
| Tawfik, VL | 1 |
| Pradhan, AA | 9 |
| Mao, Q | 1 |
| Cui, Y | 1 |
| Du, H | 1 |
| Wu, J | 1 |
| Zhou, M | 1 |
| Ouyang, H | 1 |
| Feng, Y | 2 |
| Yang, S | 2 |
| Greco, R | 25 |
| Demartini, C | 15 |
| Zanaboni, AM | 12 |
| Francavilla, M | 8 |
| Reggiani, A | 3 |
| Realini, N | 2 |
| Scarpelli, R | 1 |
| Piomelli, D | 2 |
| Tassorelli, C | 30 |
| Yang, DG | 1 |
| Gao, YY | 1 |
| Yin, ZQ | 1 |
| Wang, XR | 1 |
| Meng, XS | 1 |
| Zou, TF | 1 |
| Duan, YJ | 1 |
| Chen, YL | 1 |
| Liao, CZ | 1 |
| Xie, ZL | 1 |
| Fan, XD | 1 |
| Sun, L | 1 |
| Han, JH | 1 |
| Yang, XX | 1 |
| Wu, S | 2 |
| Ren, X | 1 |
| Zhu, C | 1 |
| Wang, W | 3 |
| Zhang, K | 1 |
| Li, Z | 3 |
| Liu, X | 2 |
| Magni, G | 3 |
| Riboldi, B | 3 |
| Nativi, C | 4 |
| Ceruti, S | 3 |
| Foudah, AI | 3 |
| Devi, S | 3 |
| Alqarni, MH | 3 |
| Alam, A | 3 |
| Salkini, MA | 3 |
| Kumar, M | 3 |
| Almalki, HS | 3 |
| Guo, S | 2 |
| Hay-Schmidt, A | 5 |
| Ashina, M | 7 |
| Chou, TM | 2 |
| Lee, ZF | 2 |
| Wang, SJ | 2 |
| Lien, CC | 2 |
| Chen, SP | 2 |
| Wang, Z | 1 |
| Lin, Q | 1 |
| Peng, YB | 1 |
| Sodergren, MH | 1 |
| Facchetti, S | 2 |
| Pacchetti, B | 1 |
| Palmisani, M | 2 |
| Franco, V | 2 |
| Zhang, L | 4 |
| Zhou, Y | 3 |
| Yang, L | 2 |
| Xiao, Z | 2 |
| He, W | 4 |
| Luo, Y | 1 |
| Qiu, Y | 1 |
| Zhou, R | 1 |
| Ji, X | 1 |
| Liu, Z | 1 |
| Li, R | 4 |
| Hou, J | 1 |
| Zhang, S | 5 |
| Wang, T | 2 |
| Song, H | 1 |
| Tao, X | 1 |
| Karsan, N | 7 |
| Bose, RP | 1 |
| O'Daly, O | 2 |
| Zelaya, F | 1 |
| Goadsby, PJ | 11 |
| Barbosa, IR | 1 |
| Cunha, G | 1 |
| Luft, C | 1 |
| Rübensam, G | 1 |
| Freitas, RDS | 1 |
| Greggio, S | 1 |
| Venturin, G | 1 |
| Oliveira, JR | 1 |
| Costa, JC | 1 |
| Campos, MM | 1 |
| Zhang, X | 3 |
| Jing, F | 3 |
| Zou, Q | 3 |
| Pu, Y | 1 |
| Sokolov, AY | 1 |
| Volynsky, MA | 1 |
| Potapenko, AV | 1 |
| Iurkova, PM | 1 |
| Zaytsev, VV | 1 |
| Nippolainen, E | 1 |
| Kamshilin, AA | 1 |
| Xu, M | 1 |
| Shi, Z | 2 |
| He, Z | 1 |
| Ling, X | 1 |
| Liu, H | 1 |
| Gong, M | 1 |
| Xie, W | 1 |
| Ma, Z | 1 |
| Miao, S | 1 |
| Li, C | 2 |
| Yang, C | 1 |
| Li, B | 1 |
| Gong, Z | 1 |
| Shafique, U | 1 |
| Din, FU | 1 |
| Sohail, S | 1 |
| Batool, S | 1 |
| Almari, AH | 1 |
| Lahiq, AA | 1 |
| Fatease, AA | 1 |
| Alharbi, HM | 1 |
| Lai, T | 1 |
| Chen, X | 1 |
| He, J | 1 |
| Lv, P | 1 |
| Ge, H | 1 |
| van Oosterhout, WP | 1 |
| Schoonman, GG | 6 |
| Saal, DP | 1 |
| Thijs, RD | 1 |
| van Dijk, JG | 1 |
| Tumelero, E | 2 |
| Misto, A | 1 |
| De Icco, R | 4 |
| Perrotta, A | 1 |
| Grillo, V | 2 |
| Cosentino, G | 1 |
| Sances, G | 4 |
| Sandrini, G | 12 |
| Potewiratnanond, P | 1 |
| le Grand, SM | 1 |
| Srikiatkhachorn, A | 1 |
| Supronsinchai, W | 1 |
| Shi, S | 1 |
| Han, Y | 3 |
| Wang, D | 1 |
| Guo, P | 1 |
| Wang, J | 1 |
| Ren, T | 1 |
| Kilinc, E | 2 |
| Tore, F | 1 |
| Dagistan, Y | 2 |
| Bugdayci, G | 1 |
| Pettingill, P | 1 |
| Weir, GA | 1 |
| Wei, T | 1 |
| Wu, Y | 1 |
| Flower, G | 1 |
| Lalic, T | 1 |
| Handel, A | 1 |
| Duggal, G | 1 |
| Chintawar, S | 1 |
| Cheung, J | 1 |
| Arunasalam, K | 1 |
| Couper, E | 1 |
| Haupt, LM | 1 |
| Griffiths, LR | 1 |
| Bassett, A | 1 |
| Cowley, SA | 1 |
| Cader, MZ | 1 |
| Luo, YM | 1 |
| Ren, XQ | 1 |
| Yang, XQ | 1 |
| Song, HR | 1 |
| Gao, MH | 1 |
| Li, YR | 1 |
| Zhou, RR | 1 |
| Ma, L | 1 |
| Zhang, SJ | 1 |
| Dong, RJ | 1 |
| Ge, DY | 1 |
| Wang, CG | 1 |
| Ren, QJ | 1 |
| Tao, XH | 1 |
| El-Nabarawy, NA | 1 |
| Teaima, MH | 1 |
| Helal, DA | 1 |
| Long, T | 4 |
| Zhang, J | 1 |
| Czerpaniak, K | 1 |
| Huang, L | 1 |
| Cloud, ME | 1 |
| Unsinger, J | 1 |
| Hotchkiss, RS | 1 |
| Li, D | 1 |
| Cao, YQ | 1 |
| Lin, J | 2 |
| Lu, H | 1 |
| Chen, J | 2 |
| Yang, X | 1 |
| Wu, Z | 1 |
| Bose, PR | 3 |
| Thompson, C | 1 |
| Newman, J | 1 |
| Xu, YS | 1 |
| Qiu, F | 1 |
| He, R | 1 |
| Gong, MX | 1 |
| Wang, ZM | 1 |
| Targowska-Duda, KM | 1 |
| Ozawa, A | 1 |
| Cippitelli, A | 1 |
| Marcus, JL | 1 |
| Mielke-Maday, HK | 1 |
| Zribi, G | 1 |
| Rainey, AN | 1 |
| Kieffer, BL | 2 |
| Toll, L | 1 |
| Dool, J | 1 |
| Pérez-Pereda, S | 1 |
| González-Quintanilla, V | 1 |
| Madera, J | 1 |
| Pascual, J | 1 |
| Shu, H | 3 |
| Liu, S | 3 |
| Tang, Y | 4 |
| Schmidt, BL | 1 |
| Dolan, JC | 1 |
| Bellinger, LL | 1 |
| Kramer, PR | 1 |
| Bender, SD | 1 |
| Tao, F | 3 |
| Tian, K | 1 |
| Fan, X | 1 |
| Zelaya, FO | 1 |
| Ankarali, S | 1 |
| Torun, IE | 1 |
| Kooshki, R | 2 |
| Abbasnejad, M | 2 |
| Shamsizadeh, A | 1 |
| Raoof, M | 2 |
| Askari-Zahabi, K | 1 |
| Esmaeili-Mahani, S | 2 |
| Lu, F | 1 |
| Zhang, WJ | 3 |
| Zhai, S | 1 |
| Sun, YW | 1 |
| Chen, QJ | 1 |
| Yang, XL | 1 |
| Zhang, CF | 4 |
| Wang, CZ | 4 |
| Yuan, CS | 4 |
| Sheibani, V | 1 |
| Dripps, IJ | 1 |
| Moye, LS | 3 |
| Tipton, AF | 4 |
| Baca, SM | 2 |
| Tzeng, HR | 1 |
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| Sieghart, W | 1 |
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| Akerman, S | 2 |
| Romero-Reyes, M | 2 |
| Bose, P | 2 |
| Hoffmann, JR | 2 |
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| Leese, C | 1 |
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| van Rijn, RM | 1 |
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| Peréz-Rodríguez, A | 1 |
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| Messing, RO | 1 |
| Wang, ZJ | 1 |
| van Oosterhout, WPJ | 1 |
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| Evans, CJ | 1 |
| Charles, A | 3 |
| Feistel, S | 1 |
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| Mangione, AS | 5 |
| Siani, F | 1 |
| Blandini, F | 6 |
| Vairetti, M | 2 |
| Nappi, G | 15 |
| Buzzi, MG | 3 |
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| Dong, X | 1 |
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| Párdutz, Á | 5 |
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| Zhao, LX | 1 |
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| Chen, C | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Peripheral Gene Expression of Endocannabinoid System Components in Episodic and Chronic Migraine Patients: a Pilot Study[NCT04324710] | 75 participants (Actual) | Observational | 2017-12-12 | Completed | |||
| Neurophysiological, Biomolecular and Psychological Aspects of Erenumab Treatment in Chronic Migraine: an Open Label, Hypothesis Generator Study[NCT04361721] | 40 participants (Anticipated) | Observational | 2020-01-15 | Recruiting | |||
| Habituation of the Nociceptive Blink Reflex in Experimentally Induced Migraine Attack: a Cross-over, Randomized Controlled Study[NCT05718310] | 22 participants (Anticipated) | Interventional | 2022-11-01 | Recruiting | |||
| Biomarker Identification to Predict the Evolution of Migraine From an Episodic to a Chronic Condition[NCT04696510] | 15 participants (Actual) | Observational | 2018-08-31 | Completed | |||
| Factors Associated With Migraine Refractoriness to Preventive Treatments: Psychological Aspects and Relationship With Components of the Endocannabinoid System[NCT05046119] | 80 participants (Anticipated) | Observational | 2021-09-15 | Not yet recruiting | |||
| A Multidisciplinary Approach to the Identification of BIOmarkers of MIGraine: a Proof of Concept Study Based on the Stratification of Responders to CGRP Monoclonal Antibodies[NCT04503083] | 219 participants (Anticipated) | Observational | 2021-01-15 | Recruiting | |||
| A Phase 2a Study of the Safety and Effectiveness of NXN-188 for the Acute Treatment of Migraine Attacks With Aura[NCT00877838] | Phase 2 | 40 participants (Anticipated) | Interventional | 2009-05-31 | Recruiting | ||
| Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging[NCT01741246] | 78 participants (Actual) | Observational | 2011-09-30 | Completed | |||
| Understanding the Role of the External Carotid Artery in the Pathophysiology of Migraine Pain[NCT03026101] | 20 participants (Anticipated) | Interventional | 2017-01-31 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
19 reviews available for nitroglycerin and Abdominal Migraine
| Article | Year |
|---|---|
Neuroimaging in the pre-ictal or premonitory phase of migraine: a narrative review.
Topics: Brain; Diffusion Tensor Imaging; Headache; Humans; Migraine Disorders; Neuroimaging; Nitroglycerin; | 2023 |
Migraine and cluster headache - the common link.
Topics: Calcitonin Gene-Related Peptide; Cluster Headache; Deep Brain Stimulation; Humans; Implantable Neuro | 2018 |
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.
Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents | 2019 |
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.
Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents | 2019 |
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.
Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents | 2019 |
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.
Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents | 2019 |
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.
Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents | 2019 |
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.
Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents | 2019 |
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.
Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents | 2019 |
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.
Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents | 2019 |
Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back.
Topics: Animals; Disease Models, Animal; Humans; Migraine Disorders; Nitroglycerin; Pain; Vasodilator Agents | 2019 |
Pearls and pitfalls in human pharmacological models of migraine: 30 years' experience.
Topics: Animals; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation; Histamine; Human Experim | 2013 |
[Progression of the mechanism study on experimental migraine treated with acupuncture in rat model].
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Disease Models, Animal; Humans; Migraine Disorders | 2016 |
What have we learnt from triggering migraine?
Topics: Brain; Calcitonin Gene-Related Peptide; Cerebral Arteries; Drug Design; Humans; Migraine Disorders; | 2010 |
Peripheral and central activation of trigeminal pain pathways in migraine: data from experimental animal models.
Topics: Animals; Brain; Migraine Disorders; Models, Animal; Neurogenic Inflammation; Nitric Oxide; Nitric Ox | 2003 |
The role of nitric oxide in vascular headache.
Topics: Histamine; History, 19th Century; History, 20th Century; Humans; Migraine Disorders; Nitric Oxide; N | 2003 |
Evaluation and proposal for optimization of neurophysiological tests in migraine: part 2--neuroimaging and the nitroglycerin test.
Topics: Diagnostic Imaging; Humans; Italy; Migraine Disorders; Neurophysiology; Nitroglycerin; Practice Guid | 2007 |
Nitric oxide is a key molecule in migraine and other vascular headaches.
Topics: Amino Acid Oxidoreductases; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Headache; | 1994 |
Nitric oxide theory of migraine.
Topics: Brain; Clinical Trials as Topic; Histamine; Humans; Migraine Disorders; Neurotransmitter Agents; Nit | 1998 |
Effect of nitric oxide donors on the central nervous system--nitroglycerin studies in the rat.
Topics: Animals; Central Nervous System; Migraine Disorders; Nitric Oxide; Nitric Oxide Donors; Nitroglyceri | 2000 |
Peripheral and central sensitization during migraine.
Topics: Animals; Central Nervous System; Migraine Disorders; Nitric Oxide; Nitric Oxide Donors; Nitroglyceri | 2000 |
Human migraine models.
Topics: Animals; Cerebrovascular Circulation; Humans; Migraine Disorders; Models, Neurological; Nitroglyceri | 2001 |
Nitric oxide-induced neuronal activation in the central nervous system as an animal model of migraine: mechanisms and mediators.
Topics: Animals; Brain; Disease Models, Animal; Humans; Migraine Disorders; Neurons; Nitric Oxide; Nitroglyc | 2001 |
Vasodilatation and migraine.
Topics: Cerebrovascular Circulation; Cranial Nerve Diseases; Facial Nerve; Humans; Migraine Disorders; Nitro | 1990 |
Acephalgic migraine.
Topics: Abdomen; Amnesia; Confusion; Coronary Vasospasm; Diagnosis, Differential; Ergotamine; Ergotamines; H | 1986 |
Beta-adrenergic receptor blocking drugs.
Topics: Adrenergic beta-Antagonists; Alprenolol; Angina Pectoris; Aortic Aneurysm; Aortic Valve; Arrhythmias | 1973 |
Impedance methods for investigation of cerebral circulation.
Topics: Adenosine Triphosphate; Animals; Brain Neoplasms; Carbon Dioxide; Carotid Artery Diseases; Cerebral | 1972 |
20 trials available for nitroglycerin and Abdominal Migraine
| Article | Year |
|---|---|
Regional cerebral perfusion during the premonitory phase of triggered migraine: A double-blind randomized placebo-controlled functional imaging study using pseudo-continuous arterial spin labeling.
Topics: Brain; Cerebrovascular Circulation; Headache; Humans; Magnetic Resonance Imaging; Migraine Disorders | 2023 |
Headache and non-headache symptoms provoked by nitroglycerin in migraineurs: A human pharmacological triggering study.
Topics: Adult; Double-Blind Method; Female; Humans; Male; Migraine Disorders; Nitroglycerin; Prodromal Sympt | 2020 |
Alterations in Functional Connectivity During Different Phases of the Triggered Migraine Attack.
Topics: Adolescent; Adult; Brain Stem; Connectome; Double-Blind Method; Echo-Planar Imaging; Female; Gyrus C | 2020 |
Effect of applying reflexology massage on nitroglycerin-induced migraine-type headache: A placebo-controlled clinical trial.
Topics: Angina Pectoris; Female; Humans; Infusions, Intravenous; Male; Massage; Middle Aged; Migraine Disord | 2018 |
Nitroglycerine triggers triptan-responsive cranial allodynia and trigeminal neuronal hypersensitivity.
Topics: Adolescent; Adult; Aspirin; Double-Blind Method; Humans; Hyperalgesia; Middle Aged; Migraine Disorde | 2019 |
Nitroglycerin sensitises in healthy subjects CNS structures involved in migraine pathophysiology: evidence from a study of nociceptive blink reflexes and visual evoked potentials.
Topics: Adult; Analysis of Variance; Blinking; Dose-Response Relationship, Drug; Drug Administration Routes; | 2009 |
Rapid absorption of sumatriptan powder and effects on glyceryl trinitrate model of headache following intranasal delivery using a novel bi-directional device.
Topics: Absorption; Administration, Intranasal; Adult; Drug Delivery Systems; Electroencephalography; Female | 2009 |
Nitroglycerin provocation in normal subjects is not a useful human migraine model?
Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Over Studies; Double-Blin | 2010 |
CGRP receptor antagonist olcegepant (BIBN4096BS) does not prevent glyceryl trinitrate-induced migraine.
Topics: Adult; Calcitonin Gene-Related Peptide Receptor Antagonists; Cross-Over Studies; Dipeptides; Double- | 2010 |
A double-blind study of SB-220453 (Tonerbasat) in the glyceryltrinitrate (GTN) model of migraine.
Topics: Adult; Benzamides; Benzopyrans; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; | 2004 |
Increased dilator response to nitrate and decreased flow-mediated dilatation in migraineurs.
Topics: Adolescent; Adult; Brachial Artery; Brain; Case-Control Studies; Endothelium, Vascular; Female; Huma | 2007 |
Migraine headache is not associated with cerebral or meningeal vasodilatation--a 3T magnetic resonance angiography study.
Topics: Adult; Carotid Arteries; Cerebral Arteries; Cerebrovascular Circulation; Double-Blind Method; Female | 2008 |
The frontotemporal region plays a role in the genesis of migraine without aura.
Topics: Adolescent; Adult; Arm; Chin; Female; Forearm; Frontal Lobe; Humans; Male; Middle Aged; Migraine Dis | 1995 |
Histamine-1 receptor blockade does not prevent nitroglycerin induced migraine. Support for the NO-hypothesis of migraine.
Topics: Adult; Analysis of Variance; Cerebrovascular Circulation; Cross-Over Studies; Female; Hemodynamics; | 1996 |
Long-term outcome of migraine therapy: predictive value of the frontotemporal nitroglycerin test.
Topics: Adult; Female; Flunarizine; Follow-Up Studies; Humans; Male; Middle Aged; Migraine Disorders; Nitrog | 1998 |
The pharmacodynamics of sumatriptan in nitroglycerin-induced headache.
Topics: Adult; Analysis of Variance; Area Under Curve; Brain; Cerebral Arteries; Electrocardiography; Headac | 1999 |
Nitric oxide-induced headache in patients with chronic tension-type headache.
Topics: Adult; Chronic Disease; Cross-Over Studies; Double-Blind Method; Female; Hemodynamics; Humans; Male; | 2000 |
Headache characteristics during the development of tolerance to nitrates: pathophysiological implications.
Topics: Administration, Oral; Adult; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Female; Headac | 2000 |
Source of pain and primitive dysfunction in migraine: an identical site?
Topics: Administration, Cutaneous; Adult; Double-Blind Method; Female; Frontal Lobe; Humans; Male; Middle Ag | 1989 |
The nitroglycerine ointment test--a double-blind examination.
Topics: Clinical Trials as Topic; Ergotamine; Female; Headache; Humans; Male; Methods; Migraine Disorders; N | 1970 |
198 other studies available for nitroglycerin and Abdominal Migraine
| Article | Year |
|---|---|
Exogenous Hsp70 attenuates nitroglycerin-induced migraine-like symptoms in mice.
Topics: Adult; Animals; Disease Models, Animal; Female; HSP70 Heat-Shock Proteins; Humans; Male; Mice; Mice, | 2021 |
The gut microbiome modulates nitroglycerin-induced migraine-related hyperalgesia in mice.
Topics: Animals; Gastrointestinal Microbiome; Humans; Hyperalgesia; Mice; Migraine Disorders; Nitroglycerin; | 2022 |
SCFA Treatment Alleviates Pathological Signs of Migraine and Related Intestinal Alterations in a Mouse Model of NTG-Induced Migraine.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Down-Regulation; Fatty Acids, | 2021 |
MicroRNA-155-5p promotes neuroinflammation and central sensitization via inhibiting SIRT1 in a nitroglycerin-induced chronic migraine mouse model.
Topics: Animals; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Migraine Disorders; Neur | 2021 |
Cortical glutamate and gamma-aminobutyric acid over the course of a provoked migraine attack, a 7 Tesla magnetic resonance spectroscopy study.
Topics: Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Spectroscopy; Migraine Di | 2021 |
IL-17 crosses the blood-brain barrier to trigger neuroinflammation: a novel mechanism in nitroglycerin-induced chronic migraine.
Topics: Animals; Blood-Brain Barrier; Disease Models, Animal; Humans; Interleukin-17; Migraine Disorders; Ne | 2022 |
Classical prescription Dachuanxiong Formula delays nitroglycerin-induced pain response in migraine mice through reducing endothelin-1 level and regulating fatty acid biosynthesis.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelin | 2022 |
The PACAP pathway is independent of CGRP in mouse models of migraine: possible new drug target?
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Mice; Migraine Disorders; Nitrogly | 2022 |
Sphingosine-1 phosphate receptor 1 contributes to central sensitization in recurrent nitroglycerin-induced chronic migraine model.
Topics: Animals; Central Nervous System Sensitization; Disease Models, Animal; Hyperalgesia; Mice; Migraine | 2022 |
Transient receptor potential melastatin 8 is required for nitroglycerin- and calcitonin gene-related peptide-induced migraine-like pain behaviors in mice.
Topics: Animals; Calcitonin Gene-Related Peptide; Cold Temperature; Genome-Wide Association Study; Mice; Mig | 2022 |
Supplementation with SCFAs Re-Establishes Microbiota Composition and Attenuates Hyperalgesia and Pain in a Mouse Model of NTG-Induced Migraine.
Topics: Animals; Butyric Acid; Dietary Supplements; Disease Models, Animal; Fatty Acids, Volatile; Gastroint | 2022 |
Hyperhomocysteinemia Increases Cortical Excitability and Aggravates Mechanical Hyperalgesia and Anxiety in a Nitroglycerine-Induced Migraine Model in Rats.
Topics: Animals; Anxiety; Cortical Excitability; Female; Homocysteine; Hyperalgesia; Hyperhomocysteinemia; M | 2022 |
Migraine and peripheral pain models show differential alterations in neuronal complexity.
Topics: Animals; Complex Regional Pain Syndromes; Cortical Spreading Depression; Disease Models, Animal; Hea | 2022 |
San Pian decoction can treat nitroglycerin-induced migraine in rats by inhibiting the PI3K/AKT and MAPK signaling pathways.
Topics: Animals; Drugs, Chinese Herbal; Interleukin-6; MAP Kinase Signaling System; Migraine Disorders; Nitr | 2022 |
Potentiation of endocannabinoids and other lipid amides prevents hyperalgesia and inflammation in a pre-clinical model of migraine.
Topics: Amides; Amidohydrolases; Animals; Disease Models, Animal; Endocannabinoids; Hyperalgesia; Inflammati | 2022 |
Roxadustat alleviates nitroglycerin-induced migraine in mice by regulating HIF-1α/NF-κB/inflammation pathway.
Topics: Animals; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Mice; Migraine Disorders; NF-kappa | 2023 |
Modelling migraine-related features in the nitroglycerin animal model: Trigeminal hyperalgesia is associated with affective status and motor behavior.
Topics: Animals; Disease Models, Animal; Formaldehyde; Hyperalgesia; Male; Migraine Disorders; Nitroglycerin | 2022 |
A c-Fos activation map in nitroglycerin/levcromakalim-induced models of migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Crom | 2022 |
Antagonism of CGRP Receptor: Central and Peripheral Mechanisms and Mediators in an Animal Model of Chronic Migraine.
Topics: Animals; Ankyrins; Calcitonin; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Rece | 2022 |
Modulation of Glia Activation by TRPA1 Antagonism in Preclinical Models of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cytoskeletal Proteins; Hyperalgesia; Migraine Disorders; N | 2022 |
Modulation of Glia Activation by TRPA1 Antagonism in Preclinical Models of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cytoskeletal Proteins; Hyperalgesia; Migraine Disorders; N | 2022 |
Modulation of Glia Activation by TRPA1 Antagonism in Preclinical Models of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cytoskeletal Proteins; Hyperalgesia; Migraine Disorders; N | 2022 |
Modulation of Glia Activation by TRPA1 Antagonism in Preclinical Models of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cytoskeletal Proteins; Hyperalgesia; Migraine Disorders; N | 2022 |
Modulation of Glia Activation by TRPA1 Antagonism in Preclinical Models of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cytoskeletal Proteins; Hyperalgesia; Migraine Disorders; N | 2022 |
Modulation of Glia Activation by TRPA1 Antagonism in Preclinical Models of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cytoskeletal Proteins; Hyperalgesia; Migraine Disorders; N | 2022 |
Modulation of Glia Activation by TRPA1 Antagonism in Preclinical Models of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cytoskeletal Proteins; Hyperalgesia; Migraine Disorders; N | 2022 |
Modulation of Glia Activation by TRPA1 Antagonism in Preclinical Models of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cytoskeletal Proteins; Hyperalgesia; Migraine Disorders; N | 2022 |
Modulation of Glia Activation by TRPA1 Antagonism in Preclinical Models of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cytoskeletal Proteins; Hyperalgesia; Migraine Disorders; N | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
Quercetin Attenuates Nitroglycerin-Induced Migraine Headaches by Inhibiting Oxidative Stress and Inflammatory Mediators.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation Mediators; Migraine Disorders; Nitroglyc | 2022 |
PACAP signaling is not involved in GTN- and levcromakalim-induced hypersensitivity in mouse models of migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cromakalim; Disease Models, Animal; Drug Hypersensitivity; | 2022 |
PACAP signaling is not involved in GTN- and levcromakalim-induced hypersensitivity in mouse models of migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cromakalim; Disease Models, Animal; Drug Hypersensitivity; | 2022 |
PACAP signaling is not involved in GTN- and levcromakalim-induced hypersensitivity in mouse models of migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cromakalim; Disease Models, Animal; Drug Hypersensitivity; | 2022 |
PACAP signaling is not involved in GTN- and levcromakalim-induced hypersensitivity in mouse models of migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cromakalim; Disease Models, Animal; Drug Hypersensitivity; | 2022 |
CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Central Amygdaloid Nucleus; Hyperalgesia; Mice; Migraine D | 2022 |
CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Central Amygdaloid Nucleus; Hyperalgesia; Mice; Migraine D | 2022 |
CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Central Amygdaloid Nucleus; Hyperalgesia; Mice; Migraine D | 2022 |
CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Central Amygdaloid Nucleus; Hyperalgesia; Mice; Migraine D | 2022 |
Multi-region local field potential signatures and brain coherence alternations in response to nitroglycerin-induced migraine attacks.
Topics: Animals; Brain; Disease Models, Animal; Hyperalgesia; Migraine Disorders; Nitroglycerin; Rats | 2023 |
Characterization of the biochemical and behavioral effects of cannabidiol: implications for migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cannabidiol; Disease Models, Animal; Hyperalgesia; Male; M | 2023 |
PACAP6-38 improves nitroglycerin-induced central sensitization by modulating synaptic plasticity at the trigeminal nucleus caudalis in a male rat model of chronic migraine.
Topics: Animals; Brain-Derived Neurotrophic Factor; Central Nervous System Sensitization; Male; Migraine Dis | 2023 |
The status of knowledge on migraines: The role of microglia.
Topics: Animals; Hyperalgesia; Microglia; Migraine Disorders; Nitroglycerin; Signal Transduction | 2023 |
Shaoyao Gancao decoction alleviates the central hyperalgesia of recurrent NTG-induced migraine in rats by regulating the NGF/TRPV1/COX-2 signal pathway.
Topics: Animals; Calcitonin Gene-Related Peptide; Cyclooxygenase 2; Extracellular Signal-Regulated MAP Kinas | 2023 |
Fructose supplementation shifts rat brain metabolism in experimental migraine.
Topics: Animals; Brain; Dietary Supplements; Disease Models, Animal; Fructose; Glucose; Male; Migraine Disor | 2023 |
Activity of FAAH-Inhibitor JZP327A in an Experimental Rat Model of Migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Endocannabinoids; Hyperalgesia; Ma | 2023 |
Inhibition of glutamatergic trigeminal nucleus caudalis- vestibular nucleus projection neurons attenuates vestibular dysfunction in the chronic-NTG model of migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Migraine Disorders; Neurons; Nitroglycerin; Rats; Trigemin | 2023 |
GLP-1R agonist liraglutide attenuates pain hypersensitivity by stimulating IL-10 release in a nitroglycerin-induced chronic migraine mouse model.
Topics: Animals; Disease Models, Animal; Glucagon-Like Peptide-1 Receptor; Hyperalgesia; Interleukin-10; Lir | 2023 |
Duality in response of intracranial vessels to nitroglycerin revealed in rats by imaging photoplethysmography.
Topics: Animals; Migraine Disorders; Nitroglycerin; Photoplethysmography; Rats; Sumatriptan; Vasodilator Age | 2023 |
Aryl hydrocarbon receptors improve migraine-like pain behaviors in rats through the regulation of regulatory T cell/T-helper 17 cell-related homeostasis.
Topics: Animals; Calcitonin Gene-Related Peptide; Homeostasis; Migraine Disorders; Nitroglycerin; Pain Thres | 2023 |
Rutaecarpine alleviates migraine in nitroglycerin-induced mice by regulating PTEN/PGK1 signaling pathway to activate NRF2 antioxidant system.
Topics: Animals; Antioxidants; Hydrogen Peroxide; Mice; Migraine Disorders; NF-E2-Related Factor 2; Nitrogly | 2023 |
Proteomics profiling reveals mitochondrial damage in the thalamus in a mouse model of chronic migraine.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Mice; Migraine Disorders; Nitroglycerin; Pr | 2023 |
Quality by design for sumatriptan loaded nano-ethosomal mucoadhesive gel for the therapeutic management of nitroglycerin induced migraine.
Topics: Administration, Intranasal; Humans; Migraine Disorders; Nasal Mucosa; Nitroglycerin; Sumatriptan | 2023 |
Rhynchophylline attenuates migraine in trigeminal nucleus caudalis in nitroglycerin-induced rat model by inhibiting MAPK/NF-кB signaling.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Male; MAP Kinase Signalin | 2019 |
Abnormal cardiovascular response to nitroglycerin in migraine.
Topics: Administration, Intravenous; Adult; Blood Pressure; Case-Control Studies; Female; Heart Rate; Humans | 2020 |
FAAH inhibition as a preventive treatment for migraine: A pre-clinical study.
Topics: Amidohydrolases; Animals; Benzamides; Carbamates; Disease Models, Animal; Male; Migraine Disorders; | 2020 |
Experimentally induced spinal nociceptive sensitization increases with migraine frequency: a single-blind controlled study.
Topics: Adolescent; Adult; Case-Control Studies; Central Nervous System Sensitization; Female; Humans; Male; | 2020 |
Experimentally induced spinal nociceptive sensitization increases with migraine frequency: a single-blind controlled study.
Topics: Adolescent; Adult; Case-Control Studies; Central Nervous System Sensitization; Female; Humans; Male; | 2020 |
Experimentally induced spinal nociceptive sensitization increases with migraine frequency: a single-blind controlled study.
Topics: Adolescent; Adult; Case-Control Studies; Central Nervous System Sensitization; Female; Humans; Male; | 2020 |
Experimentally induced spinal nociceptive sensitization increases with migraine frequency: a single-blind controlled study.
Topics: Adolescent; Adult; Case-Control Studies; Central Nervous System Sensitization; Female; Humans; Male; | 2020 |
Altered activity in the nucleus raphe magnus underlies cortical hyperexcitability and facilitates trigeminal nociception in a rat model of medication overuse headache.
Topics: Acetaminophen; Action Potentials; Animals; Cerebral Cortex; Disease Models, Animal; Headache Disorde | 2019 |
PD-L1 and PD-1 expressed in trigeminal ganglia may inhibit pain in an acute migraine model.
Topics: Acute Disease; Animals; B7-H1 Antigen; Disease Models, Animal; Gene Expression; Male; Mice; Mice, In | 2020 |
Thymoquinone Inhibits Neurogenic Inflammation Underlying Migraine Through Modulation of Calcitonin Gene-Related Peptide Release and Stabilization of Meningeal Mast Cells in Glyceryltrinitrate-Induced Migraine Model in Rats.
Topics: Animals; Anti-Inflammatory Agents; Benzoquinones; Calcitonin Gene-Related Peptide; Disease Models, A | 2020 |
A causal role for TRESK loss of function in migraine mechanisms.
Topics: Animals; CRISPR-Cas Systems; Disease Models, Animal; Humans; Induced Pluripotent Stem Cells; Loss of | 2019 |
Tibetan medicine Ru-yi-Zhen-bao Pills exhibits anti-migraine effect through mediating PAG anti-nociceptive channel.
Topics: Animals; Calcitonin Gene-Related Peptide; Cholecystokinin; Disease Models, Animal; Drugs, Chinese He | 2020 |
Assessment Of Spanlastic Vesicles Of Zolmitriptan For Treating Migraine In Rats.
Topics: Administration, Intranasal; Animals; Injections, Intraperitoneal; Male; Migraine Disorders; Nitrogly | 2019 |
Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model.
Topics: Adenosine Triphosphate; Animals; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Related Peptide; | 2020 |
Low-dose interleukin-2 reverses behavioral sensitization in multiple mouse models of headache disorders.
Topics: Animals; Headache Disorders; Interleukin-2; Mice; Migraine Disorders; Nitroglycerin; Sumatriptan | 2020 |
Dimethyl fumarate alleviates the nitroglycerin (NTG)-induced migraine in mice.
Topics: Animals; Cells, Cultured; Dimethyl Fumarate; Dose-Response Relationship, Drug; Immunosuppressive Age | 2020 |
Evodiamine via targeting nNOS and AMPA receptor GluA1 inhibits nitroglycerin-induced migraine-like response.
Topics: Analgesics; Animals; Hyperalgesia; Male; Migraine Disorders; Nitric Oxide; Nitric Oxide Synthase Typ | 2020 |
No central action of CGRP antagonising drugs in the GTN mouse model of migraine.
Topics: Animals; Antibodies, Monoclonal; Calcitonin Gene-Related Peptide Receptor Antagonists; Disease Model | 2020 |
[UPLC-MS/MS determination of active components from Wuzhuyu Decoction in plasma and brain tissues of nitroglycerin-induced migraine rats].
Topics: Administration, Oral; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Drugs, | 2020 |
NOP receptor agonist attenuates nitroglycerin-induced migraine-like symptoms in mice.
Topics: Animals; Dose-Response Relationship, Drug; Female; Imidazoles; Male; Mice; Mice, Inbred C57BL; Mice, | 2020 |
Premonitory symptoms in glyceryl trinitrate triggered migraine attacks: a case-control study.
Topics: Case-Control Studies; Female; Humans; Migraine Disorders; Nitroglycerin; Photophobia; Yawning | 2020 |
Chronic Migraine With Apparent Loss of Response to Onabotulinum Toxin Type A Due to Local Nitroglycerin Treatment for an Anal Fissure: A Case Report.
Topics: Adult; Botulinum Toxins, Type A; Female; Fissure in Ano; Humans; Migraine Disorders; Neuromuscular A | 2020 |
A Pre-Existing Myogenic Temporomandibular Disorder Increases Trigeminal Calcitonin Gene-Related Peptide and Enhances Nitroglycerin-Induced Hypersensitivity in Mice.
Topics: Animals; Biomarkers; Calcitonin Gene-Related Peptide; Disease Models, Animal; Disease Susceptibility | 2020 |
Calcitonin gene-related peptide facilitates sensitization of the vestibular nucleus in a rat model of chronic migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Hyperalgesia; Male; Migraine Disorders; Nitroglycerin; Pro | 2020 |
Receptor mechanisms mediating the anti-neuroinflammatory effects of endocannabinoid system modulation in a rat model of migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Endocannabinoids; Male; Migraine Disorders; Neurogenic Inf | 2022 |
Physical exercise enhances vulnerability to migraine headache associated with CGRP up-expression in trigeminal nucleus caudalis of stressed rats.
Topics: Animals; Calcitonin; Calcitonin Gene-Related Peptide; Disease Models, Animal; Female; Hyperalgesia; | 2020 |
Anti-migraine effect of wine-processed Radix scutellariae: Pharmacodynamic verification in nitroglycerin-induced rats and correlation study between compounds dissolution and the fractal dimension.
Topics: Animals; Fractals; Male; Migraine Disorders; Nitroglycerin; Plant Extracts; Rats; Rats, Sprague-Dawl | 2020 |
Activation orexin 1 receptors in the ventrolateral periaqueductal gray matter attenuate nitroglycerin-induced migraine attacks and calcitonin gene related peptide up-regulation in trigeminal nucleus caudalis of rats.
Topics: Animals; Benzoxazoles; Calcitonin Gene-Related Peptide; Male; Microinjections; Migraine Disorders; N | 2020 |
Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Benzamides; Cortical Spreading Depression; Disease Models, Animal; GABA | 2020 |
α6GABA
Topics: Animals; Disease Models, Animal; Fluorescent Antibody Technique; GABA Plasma Membrane Transport Prot | 2021 |
Therapeutic targeting of nitroglycerin-mediated trigeminovascular neuronal hypersensitivity predicts clinical outcomes of migraine abortives.
Topics: Animals; Headache; Hyperalgesia; Migraine Disorders; Neurons; Nitroglycerin; Rats | 2021 |
Double-Binding Botulinum Molecule with Reduced Muscle Paralysis: Evaluation in In Vitro and In Vivo Models of Migraine.
Topics: Analgesics; Animals; Botulinum Toxins; Cell Line, Tumor; Disease Models, Animal; Electromyography; H | 2021 |
A non-convulsant delta-opioid receptor agonist, KNT-127, reduces cortical spreading depression and nitroglycerin-induced allodynia.
Topics: Analgesics, Opioid; Animals; Cortical Spreading Depression; Disease Models, Animal; Female; Hyperalg | 2021 |
P2X7R-mediated autophagic impairment contributes to central sensitization in a chronic migraine model with recurrent nitroglycerin stimulation in mice.
Topics: Animals; Autophagy; Central Nervous System Sensitization; Chronic Disease; Disease Models, Animal; M | 2021 |
The migraine postdrome: Spontaneous and triggered phenotypes.
Topics: Adolescent; Adult; Fatigue; Female; Headache; Humans; Male; Middle Aged; Migraine Disorders; Nausea; | 2021 |
Spinal nociceptive sensitization and plasma palmitoylethanolamide levels during experimentally induced migraine attacks.
Topics: Amides; Ethanolamines; Humans; Migraine Disorders; Nitroglycerin; Nociception; Palmitic Acids | 2021 |
Spinal nociceptive sensitization and plasma palmitoylethanolamide levels during experimentally induced migraine attacks.
Topics: Amides; Ethanolamines; Humans; Migraine Disorders; Nitroglycerin; Nociception; Palmitic Acids | 2021 |
Spinal nociceptive sensitization and plasma palmitoylethanolamide levels during experimentally induced migraine attacks.
Topics: Amides; Ethanolamines; Humans; Migraine Disorders; Nitroglycerin; Nociception; Palmitic Acids | 2021 |
Spinal nociceptive sensitization and plasma palmitoylethanolamide levels during experimentally induced migraine attacks.
Topics: Amides; Ethanolamines; Humans; Migraine Disorders; Nitroglycerin; Nociception; Palmitic Acids | 2021 |
Insulin-like growth factor-1 inhibits nitroglycerin-induced trigeminal activation of oxidative stress, calcitonin gene-related peptide and c-Fos expression.
Topics: Administration, Intranasal; Animals; Calcitonin Gene-Related Peptide; Female; Insulin-Like Growth Fa | 2021 |
Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition.
Topics: Acetylation; Animals; Behavior, Animal; Brain; Calcitonin Gene-Related Peptide Receptor Antagonists; | 2021 |
Protein kinase Cδ as a neuronal mechanism for headache in a chronic intermittent nitroglycerin model of migraine in mice.
Topics: Animals; Disease Models, Animal; Headache; Hyperalgesia; Mice; Migraine Disorders; Nitroglycerin; Pr | 2021 |
Hypothalamic functional MRI activity in the initiation phase of spontaneous and glyceryl trinitrate-induced migraine attacks.
Topics: Cognition; Female; Humans; Hypothalamus; Magnetic Resonance Imaging; Migraine Disorders; Nitroglycer | 2021 |
Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation.
Topics: Animals; Central Nervous System Sensitization; Glucagon-Like Peptide-1 Receptor; Mice; Microglia; Mi | 2021 |
Involvement of P2Y
Topics: Animals; Disease Models, Animal; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Migraine Disorders; N | 2021 |
Involvement of TRPM2 in the Neurobiology of Experimental Migraine: Focus on Oxidative Stress and Apoptosis.
Topics: Adenosine Diphosphate Ribose; Animals; Apoptosis; Boron Compounds; Calcium Signaling; Caspases; Cinn | 2021 |
Bergapten Attenuates Nitroglycerin-Induced Migraine Headaches through Inhibition of Oxidative Stress and Inflammatory Mediators.
Topics: 5-Methoxypsoralen; Animals; Inflammation Mediators; Migraine Disorders; Nitroglycerin; Oxidative Str | 2021 |
Analgesia effect of baicalein against NTG-induced migraine in rats.
Topics: Analgesia; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Endothelins; Flavanones | 2017 |
Nitroglycerin challenge induces lateralized headache in nasociliarynerve-ligated rats: implications for chronic migraine.
Topics: Animals; Brain Chemistry; Disease Models, Animal; Male; Maze Learning; Migraine Disorders; Nitroglyc | 2017 |
The effects of repeated nitroglycerin administrations in rats; modeling migraine-related endpoints and chronification.
Topics: Animals; Disease Models, Animal; Drug Administration Schedule; Endpoint Determination; Hyperalgesia; | 2017 |
The enhancement mechanism of wine-processed Radix Scutellaria on NTG-induced migraine rats.
Topics: Animals; Behavior, Animal; Fractals; Male; Migraine Disorders; Nitroglycerin; Plant Extracts; Porosi | 2017 |
Baicalin Alleviates Nitroglycerin-induced Migraine in Rats via the Trigeminovascular System.
Topics: Animals; Calcitonin Gene-Related Peptide; Endothelins; Female; Flavonoids; Male; Migraine Disorders; | 2017 |
Animal Model of Chronic Migraine-Associated Pain.
Topics: Animals; Association Learning; Chronic Pain; Disease Models, Animal; Female; Hyperalgesia; Mice; Mic | 2017 |
Selective cephalic upregulation of p-ERK, CamKII and p-CREB in response to glyceryl trinitrate infusion.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic AMP Response Element-Binding Pro | 2018 |
The role of the transient receptor potential ankyrin type-1 (TRPA1) channel in migraine pain: evaluation in an animal model.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Hyperalgesia; Male; Migraine Disor | 2017 |
Valproate Plays a Protective Role against Migraine by Inhibiting Protein Kinase C Signalling in Nitroglycerin-treated Mice.
Topics: Animals; Dura Mater; Enzyme Inhibitors; Injections, Intraperitoneal; Isoenzymes; Male; Mice, Inbred | 2018 |
Soluble guanylyl cyclase is a critical regulator of migraine-associated pain.
Topics: Adrenergic beta-Antagonists; Allosteric Regulation; Animals; Anticonvulsants; Calcitonin Gene-Relate | 2018 |
Differential Development of Facial and Hind Paw Allodynia in a Nitroglycerin-Induced Mouse Model of Chronic Migraine: Role of Capsaicin Sensitive Primary Afferents.
Topics: Animals; Capsaicin; Cold Temperature; Diterpenes; Drug Resistance; Facial Nerve Diseases; Hindlimb; | 2018 |
Preemptive Analgesic and Antioxidative Effect of Curcumin for Experimental Migraine.
Topics: Analgesics; Animals; Antioxidants; Curcumin; Humans; Indomethacin; Malondialdehyde; Migraine Disorde | 2017 |
AMPA receptor GluA1 Ser831 phosphorylation is critical for nitroglycerin-induced migraine-like pain.
Topics: Animals; Avoidance Learning; Calcium; Cells, Cultured; Disease Models, Animal; Hyperalgesia; Locomot | 2018 |
Cerebrolysin attenuates hyperalgesia, photophobia, and neuroinflammation in a nitroglycerin-induced migraine model in rats.
Topics: Amino Acids; Animals; Central Nervous System Agents; Disease Models, Animal; Grooming; Hyperalgesia; | 2018 |
The effect of intravenous administration of liposomal curcumin in addition to sumatriptan treatment in an experimental migraine model in rats.
Topics: Administration, Intravenous; Animals; Curcumin; Disease Models, Animal; Liposomes; Male; Malondialde | 2018 |
Dynamic sodium imaging at ultra-high field reveals progression in a preclinical migraine model.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Disease Progression; Dose-Response Relationsh | 2018 |
TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice.
Topics: Aldehyde Dehydrogenase, Mitochondrial; Animals; Cell Body; Headache; Hyperalgesia; Male; Mice; Mice, | 2018 |
Microglia P2X4 receptor contributes to central sensitization following recurrent nitroglycerin stimulation.
Topics: Animals; Benzodiazepinones; Calcitonin Gene-Related Peptide; Calcium-Binding Proteins; Disease Model | 2018 |
Reply to: Endothelium-dependent and -independent functions in migraineurs.
Topics: Endothelium, Vascular; Humans; Migraine Disorders; Nitroglycerin; Vasodilation; Vasodilator Agents | 2019 |
Endothelium-dependent and -independent functions in migraineurs.
Topics: Endothelium, Vascular; Humans; Migraine Disorders; Nitroglycerin; Vasodilation; Vasodilator Agents | 2019 |
Dissecting out migraine complexity through comprehensive analysis of allodynia.
Topics: Humans; Hyperalgesia; Migraine Disorders; Nitroglycerin; Tryptamines | 2019 |
Alkaloids from the rhizomes of Ligusticum striatum exert antimigraine effects through regulating 5-HT
Topics: Alkaloids; Animals; Brain; Female; Hydroxyindoleacetic Acid; Ligusticum; Male; Mice; Migraine Disord | 2019 |
Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium-Binding Proteins; Central Nervous System Sensitiza | 2019 |
Acute coronary syndrome triggered by nitro-resistant triptan-induced coronary spasm.
Topics: Acute Coronary Syndrome; Aftercare; Calcium Channel Blockers; Coronary Angiography; Coronary Vasospa | 2019 |
Effect of Paeonia lactiflora, a traditional Chinese herb, on migraines based on clinical application and animal behavior analyses.
Topics: Animals; Anxiety; Behavior, Animal; Calcitonin Gene-Related Peptide; Depression; Drugs, Chinese Herb | 2019 |
Gut Microbiota Dysbiosis Enhances Migraine-Like Pain Via TNFα Upregulation.
Topics: Animals; Anti-Bacterial Agents; Dysbiosis; Gastrointestinal Microbiome; Gene Deletion; Male; Mice, I | 2020 |
Casein kinase iδ mutations in familial migraine and advanced sleep phase.
Topics: Animals; Astrocytes; Calcium Signaling; Casein Kinase Idelta; Cortical Spreading Depression; Female; | 2013 |
Nitroglycerin-induced changes in facial skin temperature: 'cold nose' as a predictor of headache?
Topics: Administration, Sublingual; Adult; Blood Pressure; Cold Temperature; Female; Heart Rate; Humans; Mid | 2013 |
Nitric oxide synthase, calcitonin gene-related peptide and NK-1 receptor mechanisms are involved in GTN-induced neuronal activation.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dipe | 2014 |
Changes in calcitonin gene-related peptide (CGRP) receptor component and nitric oxide receptor (sGC) immunoreactivity in rat trigeminal ganglion following glyceroltrinitrate pretreatment.
Topics: Animals; Disease Models, Animal; Fluorescent Antibody Technique; Guanylate Cyclase; Immunohistochemi | 2013 |
Chest pain a manifestation of migraine.
Topics: Adult; Akathisia, Drug-Induced; Analgesics, Opioid; Chest Pain; Dopamine Antagonists; Electrocardiog | 2014 |
Characterization of a novel model of chronic migraine.
Topics: Animals; Chronic Disease; Disease Models, Animal; Female; Freund's Adjuvant; Hyperalgesia; Male; Mic | 2014 |
The calcitonin gene-related peptide receptor antagonist MK-8825 decreases spinal trigeminal activity during nitroglycerin infusion.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Male | 2013 |
Effects of CGRP receptor antagonism in nitroglycerin-induced hyperalgesia.
Topics: Animals; Calcitonin Gene-Related Peptide Receptor Antagonists; Disease Models, Animal; Hyperalgesia; | 2014 |
δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice.
Topics: Animals; Avoidance Learning; Benzamides; Cortical Spreading Depression; Female; Hyperalgesia; Male; | 2014 |
Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine.
Topics: Animals; Brain; Central Nervous System Sensitization; Disease Models, Animal; Evoked Potentials, Aud | 2014 |
Protective effects of riboflavin and selenium on brain microsomal Ca2+-ATPase and oxidative damage caused by glyceryl trinitrate in a rat headache model.
Topics: Animals; Brain; Calcium-Transporting ATPases; Disease Models, Animal; Female; Headache; Microsomes; | 2015 |
Role of phosphorylated extracellular signal-regulated kinase, calcitonin gene-related peptide and cyclooxygenase-2 in experimental rat models of migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Mod | 2015 |
Prophylactic effects of asiaticoside-based standardized extract of Centella asiatica (L.) Urban leaves on experimental migraine: Involvement of 5HT1A/1B receptors.
Topics: Administration, Intranasal; Administration, Oral; Animals; Bradykinin; Centella; Female; Hyperalgesi | 2015 |
Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice.
Topics: Amidohydrolases; Analgesics; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonist | 2015 |
Evaluation of ADMA-DDAH-NOS axis in specific brain areas following nitroglycerin administration: study in an animal model of migraine.
Topics: Amidohydrolases; Animals; Arginine; Brain; Disease Models, Animal; Drug Evaluation, Preclinical; Mal | 2015 |
The modulatory effect of anandamide on nitroglycerin-induced sensitization in the trigeminal system of the rat.
Topics: Afferent Pathways; Animals; Arachidonic Acids; Blotting, Western; Cannabinoid Receptor Agonists; Cen | 2016 |
ST-Elevation Myocardial Infarction After Sumitriptan Ingestion in Patient with Normal Coronary Arteries.
Topics: Electrocardiography; Emergency Service, Hospital; Female; Humans; Middle Aged; Migraine Disorders; M | 2015 |
The effects of acute and preventive migraine therapies in a mouse model of chronic migraine.
Topics: Acute Disease; Amiloride; Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclin | 2016 |
Pharmacological characterization of a novel gastrodin derivative as a potential anti-migraine agent.
Topics: Analgesics; Animals; Benzyl Alcohols; Calcitonin Gene-Related Peptide; Female; Glucosides; Male; Mic | 2016 |
Clinically relevant behavioral endpoints in a recurrent nitroglycerin migraine model in rats.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Male; Migraine Disorders; Motor Activity; Nitrogl | 2016 |
Valproate ameliorates nitroglycerin-induced migraine in trigeminal nucleus caudalis in rats through inhibition of NF-кB.
Topics: Animals; Blotting, Western; Calcitonin Gene-Related Peptide; Disease Models, Animal; Down-Regulation | 2016 |
RNA Sequencing of Trigeminal Ganglia in Rattus Norvegicus after Glyceryl Trinitrate Infusion with Relevance to Migraine.
Topics: Animals; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Infusions, I | 2016 |
Ictal lack of binding to brain parenchyma suggests integrity of the blood-brain barrier for 11C-dihydroergotamine during glyceryl trinitrate-induced migraine.
Topics: Adult; Blood-Brain Barrier; Dihydroergotamine; Female; Humans; Male; Middle Aged; Migraine Disorders | 2016 |
Ghrelin attenuates hyperalgesia and light aversion-induced by nitroglycerin in male rats.
Topics: Animals; Anxiety; Disease Models, Animal; Ghrelin; Hyperalgesia; Male; Migraine Disorders; Nitroglyc | 2016 |
Valproate Attenuates Nitroglycerin-Induced Trigeminovascular Activation by Preserving Mitochondrial Function in a Rat Model of Migraine.
Topics: Animals; DNA-Binding Proteins; DNA, Mitochondrial; Male; Membrane Potential, Mitochondrial; Migraine | 2016 |
Pharmacology of reflex blinks in the rat: a novel model for headache research.
Topics: Animals; Blinking; Disease Models, Animal; Electromyography; Male; Migraine Disorders; Nitric Oxide | 2016 |
Activation of the nuclear factor E2-related factor 2/anitioxidant response element alleviates the nitroglycerin-induced hyperalgesia in rats.
Topics: Animals; Anticarcinogenic Agents; Antioxidant Response Elements; Heme Oxygenase (Decyclizing); Hyper | 2016 |
Pharmacodynamic action and mechanism of Du Liang soft capsule, a traditional Chinese medicine capsule, on treating nitroglycerin-induced migraine.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Behavior, Animal; Biomarkers; Brain Stem; C | 2017 |
Chronic ghrelin treatment reduced photophobia and anxiety-like behaviors in nitroglycerin- induced migraine: role of pituitary adenylate cyclase-activating polypeptide.
Topics: Animals; Anxiety; Ghrelin; Hydrocortisone; Leukocyte Count; Male; Maze Learning; Migraine Disorders; | 2017 |
Effects of kynurenic acid analogue 1 (KYNA-A1) in nitroglycerin-induced hyperalgesia: Targets and anti-migraine mechanisms.
Topics: Animals; Excitatory Amino Acid Antagonists; Hyperalgesia; Kynurenic Acid; Male; Migraine Disorders; | 2017 |
Nitroglycerin enhances the propagation of cortical spreading depression: comparative studies with sumatriptan and novel kynurenic acid analogues.
Topics: Cortical Spreading Depression; Dose-Response Relationship, Drug; Humans; Injections, Intraperitoneal | 2017 |
Differential effects of corticosteroids on the expression of cyclooxygenase-2, tumour necrosis factor-alpha and matrix metalloproteinase-9 in an animal model of migraine.
Topics: Animals; Blotting, Western; Cyclooxygenase 2; Disease Models, Animal; Fluorescent Antibody Technique | 2008 |
[Relationship between P-type Na+ -K+ -Atpase and migraine: an experimental study with rats].
Topics: Animals; Blotting, Western; Disease Models, Animal; Female; Male; Migraine Disorders; Nitroglycerin; | 2008 |
Selective inhibition of cyclooxygenase-2 attenuates nitroglycerin-induced calmodulin-dependent protein kinase II alpha in rat trigeminal nucleus caudalis.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebral Arteries; Cerebrovascular Circ | 2009 |
Alterations of the endocannabinoid system in an animal model of migraine: evaluation in cerebral areas of rat.
Topics: Amidohydrolases; Animals; Brain; Cannabinoid Receptor Modulators; Disease Models, Animal; Endocannab | 2010 |
Migraine: migraine headache pathogenesis in historical perspective.
Topics: Causality; Cerebral Arteries; Giant Cell Arteritis; History, 20th Century; Humans; Meningeal Arterie | 2009 |
Atorvastatin attenuates NF-kappaB activation in trigeminal nucleus caudalis in a rat model of migraine.
Topics: Analysis of Variance; Animals; Atorvastatin; Blotting, Western; Cell Nucleus; Disease Models, Animal | 2009 |
[The effect of autogenic training combined with organ formula and movement therapy on spontaneous and provoked migraine headaches].
Topics: Analgesics; Analysis of Variance; Anti-Anxiety Agents; Autogenic Training; Headache Disorders, Prima | 2009 |
Coexisting typical migraine in familial hemiplegic migraine.
Topics: Adult; Aged; Analgesics; Female; Humans; Male; Middle Aged; Migraine Disorders; Migraine with Aura; | 2010 |
Temporal profile of vascular changes induced by systemic nitroglycerin in the meningeal and cortical districts.
Topics: Animals; Blood Pressure; Cerebral Cortex; Cerebrovascular Circulation; Enzyme Inhibitors; Indazoles; | 2011 |
Effect and mechanism of senkyunolide I as an anti-migraine compound from Ligusticum chuanxiong.
Topics: 5-Hydroxytryptophan; Acetates; Analgesics; Animals; Benzofurans; Brain; Dopamine; Drugs, Chinese Her | 2011 |
Effects of heating coagulation of middle meningeal artery on plasma CGRP level and c-fos expression in migraine rat triggered by nitroglycerin.
Topics: Actins; Animals; Behavior, Animal; Blotting, Western; Calcitonin Gene-Related Peptide; DNA Primers; | 2011 |
Effects of anandamide in migraine: data from an animal model.
Topics: Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Modulators; Disease M | 2011 |
Evaluation of anti-migraine potential of Areca catechu to prevent nitroglycerin-induced delayed inflammation in rat meninges: possible involvement of NOS inhibition.
Topics: Animals; Anti-Inflammatory Agents; Areca; Blood Proteins; Disease Models, Animal; Dura Mater; Enzyme | 2011 |
[Heat coagulation of middle meningeal artery affects plasma CGRP and substance P levels in migraine rat triggered by nitroglycerin].
Topics: Animals; Calcitonin Gene-Related Peptide; Electrocoagulation; Female; Meningeal Arteries; Migraine D | 2011 |
Zolmitriptan induced acute coronary syndrome: a unique case.
Topics: Acute Coronary Syndrome; Chest Pain; Electrocardiography; Humans; Male; Middle Aged; Migraine Disord | 2011 |
A naturalistic glyceryl trinitrate infusion migraine model in the rat.
Topics: Anesthesia; Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Human | 2012 |
Towards a reliable animal model of migraine.
Topics: Animals; Disease Models, Animal; Drug Design; Humans; Migraine Disorders; Nitroglycerin; Reproducibi | 2012 |
Headache in three new cases of Harlequin syndrome with accompanying pharmacological comparison with migraine.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Diagnosis, Differential; Dihydroergotamine; Ergotami | 2012 |
Effect of sex and estrogens on neuronal activation in an animal model of migraine.
Topics: Analysis of Variance; Animals; Brain; Contraceptive Agents; Disease Models, Animal; Estradiol; Femal | 2013 |
St. John's wort relieves pain in an animal model of migraine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Blotting, Western; Cold Temperat | 2013 |
Suppression by eletriptan of the activation of trigeminovascular sensory neurons by glyceryl trinitrate.
Topics: Animals; Blood Pressure; Cats; Drug Interactions; Electric Stimulation; Electrophysiology; Female; I | 2002 |
Brain blood flow in the nitroglycerin (GTN) model of migraine: measurement using positron emission tomography and transcranial Doppler.
Topics: Adolescent; Adult; Blood Flow Velocity; Brain; Female; Humans; Male; Middle Aged; Migraine Disorders | 2002 |
Reliability of the nitroglycerin provocative test in the diagnosis of neurovascular headaches.
Topics: Adult; Cluster Headache; Female; Humans; Male; Migraine Disorders; Nitroglycerin; Pedigree; Predicti | 2004 |
Reliability of the nitroglycerin provocative test in the diagnosis of neurovascular headaches.
Topics: Adult; Cluster Headache; Female; Humans; Male; Migraine Disorders; Nitroglycerin; Pedigree; Predicti | 2004 |
Reliability of the nitroglycerin provocative test in the diagnosis of neurovascular headaches.
Topics: Adult; Cluster Headache; Female; Humans; Male; Migraine Disorders; Nitroglycerin; Pedigree; Predicti | 2004 |
Reliability of the nitroglycerin provocative test in the diagnosis of neurovascular headaches.
Topics: Adult; Cluster Headache; Female; Humans; Male; Migraine Disorders; Nitroglycerin; Pedigree; Predicti | 2004 |
Nitroglycerin enhances cGMP expression in specific neuronal and cerebrovascular structures of the rat brain.
Topics: Animals; Arterioles; Brain; Cerebrovascular Circulation; Cyclic GMP; Disease Models, Animal; Immunoh | 2004 |
[Experimental headache models].
Topics: Animals; Brain; Migraine Disorders; Models, Theoretical; Nitroglycerin | 2004 |
Nitroglycerin induces migraine headache and central sensitization phenomena in patients with migraine without aura: a study of laser evoked potentials.
Topics: Adult; Carbon Dioxide; Evoked Potentials; Female; Functional Laterality; Hand; Headache; Humans; Las | 2004 |
Glyceryl trinitrate triggers premonitory symptoms in migraineurs.
Topics: Adult; Aged; Chi-Square Distribution; Female; Humans; Male; Middle Aged; Migraine Disorders; Nitrogl | 2004 |
A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate.
Topics: Adult; Aged; Brain Stem; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Mig | 2005 |
Activation of the transcription factor NF-kappaB in the nucleus trigeminalis caudalis in an animal model of migraine.
Topics: Animals; Blotting, Western; Disease Models, Animal; Immunohistochemistry; Male; Migraine Disorders; | 2005 |
Parthenolide is the component of tanacetum parthenium that inhibits nitroglycerin-induced Fos activation: studies in an animal model of migraine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Disease Models, Animal; Immunohistochemistr | 2005 |
Reliability of the nitroglycerin provocative test in the diagnosis of neurovascular headaches.
Topics: Adult; Cluster Headache; Humans; Migraine Disorders; Nitroglycerin; Predictive Value of Tests | 2005 |
[Nitroglycerin-induced headaches].
Topics: Administration, Sublingual; Adult; Calcitonin Gene-Related Peptide; Case-Control Studies; Female; He | 2004 |
Normobaric hypoxia and nitroglycerin as trigger factors for migraine.
Topics: Adult; Female; Humans; Hypoxia; Male; Migraine Disorders; Nitroglycerin; Pain Measurement; Risk Asse | 2006 |
Kynurenine in combination with probenecid mitigates the stimulation-induced increase of c-fos immunoreactivity of the rat caudal trigeminal nucleus in an experimental migraine model.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Genes, fos; Immunohistochemistry; Kynure | 2007 |
[The modulatory effect of estrogen on the caudal trigeminal nucleus of the rat in an animal model of migraine].
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calciu | 2006 |
Prevention of electrical stimulation-induced increase of c-fos immunoreaction in the caudal trigeminal nucleus by kynurenine combined with probenecid.
Topics: Adjuvants, Pharmaceutic; Afferent Pathways; Analgesics; Animals; Blood-Brain Barrier; Disease Models | 2007 |
A role for brain cyclooxygenase-2 and prostaglandin-E2 in migraine: effects of nitroglycerin.
Topics: Animals; Blotting, Western; Brain; Cyclooxygenase 2; Dinoprostone; Enzyme-Linked Immunosorbent Assay | 2007 |
Transcranial Doppler measurements in migraine and nitroglycerin headache.
Topics: Adult; Blood Flow Velocity; Cerebral Arteries; Cerebrovascular Circulation; Dose-Response Relationsh | 2007 |
Increased permeability of the blood-brain barrier following administration of glyceryl trinitrate in common carp (Cyprinus carpio L.).
Topics: Animals; Blood-Brain Barrier; Brain; Carps; Cell Membrane Permeability; Migraine Disorders; Nitric O | 2008 |
Benign paroxysmal vertigo in childhood: a migraine equivalent.
Topics: Child; Child, Preschool; Female; Fenfluramine; Histamine; Humans; Male; Migraine Disorders; Nitrogly | 1984 |
[Pathogenesis of migraine].
Topics: Blood Circulation; Cold Temperature; Fingers; Hot Temperature; Humans; Migraine Disorders; Nitroglyc | 1981 |
Nitroglycerin for ergotism. Experimental studies in vitro and in migraine patients and treatment of an overt case.
Topics: Adult; Arteries; Blood Pressure; Ergotamine; Ergotism; Female; Humans; In Vitro Techniques; Migraine | 1982 |
The nitric oxide hypothesis of migraine and other vascular headaches.
Topics: Cyclic GMP; Histamine; Humans; Migraine Disorders; Nitric Oxide; Nitroglycerin; Vascular Headaches | 1995 |
Arterial supersensitivity to nitric oxide (nitroglycerin) in migraine sufferers.
Topics: Adult; Analysis of Variance; Cerebral Arteries; Female; Humans; Male; Middle Aged; Migraine Disorder | 1993 |
Genesis of migraine without aura.
Topics: Administration, Cutaneous; Frontal Lobe; Humans; Migraine Disorders; Nitroglycerin; Temporal Lobe | 1995 |
EEG and topographic frequency analysis in migraine attack before and after sumatriptan infusion.
Topics: Adult; Electroencephalography; Female; Humans; Injections, Subcutaneous; Male; Migraine Disorders; N | 1996 |
Nitroglycerin-induced headache.
Topics: Arteriovenous Anastomosis; Dose-Response Relationship, Drug; Head; Headache; Humans; Migraine Disord | 1996 |
Effect of a nitric oxide donor on nitroxergic nerve fibers in the rat dura mater.
Topics: Animals; Axons; Blood Vessels; Dura Mater; Immunohistochemistry; Injections, Subcutaneous; Male; Mig | 1999 |
Effects of sumatriptan on nitric oxide and superoxide balance during glyceryl trinitrate infusion in the rat. Implications for antimigraine mechanisms.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Cerebrovascular Circulation; Dose-Response Relationshi | 1999 |
Glyceryl trinitrate induced headache in migraineurs - relation to attack frequency.
Topics: Adult; Female; Humans; Male; Middle Aged; Migraine Disorders; Nitric Oxide; Nitroglycerin; Time Fact | 2000 |
Systemic nitroglycerin increases nNOS levels in rat trigeminal nucleus caudalis.
Topics: Animals; Cell Count; Cerebral Arteries; Cerebrovascular Circulation; Disease Models, Animal; Male; M | 2000 |
Investigations into migraine pathogenesis: time course for effects of m-CPP, BW723C86 or glyceryl trinitrate on appearance of Fos-like immunoreactivity in rat trigeminal nucleus caudalis (TNC).
Topics: Animals; Genes, fos; Indoles; Migraine Disorders; Nitric Oxide; Nitroglycerin; Piperazines; Rats; Se | 2001 |
Functional immunohistochemistry of neuropeptides and nitric oxide synthase in the nerve fibers of the supratentorial dura mater in an experimental migraine model.
Topics: Animals; Capillaries; Dura Mater; Electric Stimulation; Female; Immunohistochemistry; Indoles; Male; | 2001 |
Delayed inflammation in rat meninges: implications for migraine pathophysiology.
Topics: Animals; Blood Proteins; Dura Mater; Gene Expression; Interleukin-1; Interleukin-6; Macrophages; Mal | 2001 |
Nuclear factor-kappaB as a molecular target for migraine therapy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; DNA-Binding Proteins; Dura Mater; I-kappa B Protei | 2002 |
Effect of systemic nitroglycerin on CGRP and 5-HT afferents to rat caudal spinal trigeminal nucleus and its modulation by estrogen.
Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Cell Size; Down-Regulation; Drug Intera | 2002 |
[Headaches in the evolutive age: nosographic classification by means of the evaluative rating scale and diagnostic tests].
Topics: Age Factors; Bromocriptine; Child; Child, Preschool; Female; Headache; Histamine; Humans; Male; Medi | 1979 |
The effect of percutaneous nitroglycerin upon the concentration of serotonin, epinephrine and norepinephrine in venous blood from migrainous subjects during attack-free intervals.
Topics: Adolescent; Adult; Epinephrine; Female; Humans; Middle Aged; Migraine Disorders; Nitroglycerin; Nore | 1975 |
Transcranial Doppler (TCD) after nitroglycerin in migraine without aura.
Topics: Adult; Blood Flow Velocity; Diastole; Female; Humans; Male; Migraine Disorders; Nitroglycerin; Pulsa | 1991 |
Unmasking latent dysnociception in healthy subjects.
Topics: Adolescent; Adult; Female; Headache; Humans; Male; Migraine Disorders; Nitroglycerin | 1987 |
Clinical aspects of cluster headache.
Topics: Adolescent; Adult; Age Factors; Aged; Blood Pressure; Electrocardiography; Female; Headache; Heart R | 1974 |
A clinical comparison of cluster headache and migraine.
Topics: Adolescent; Adult; Aged; Carotid Arteries; Chronic Disease; Diagnosis, Differential; Ergotamine; Fem | 1970 |
[Study of "medical headaches". 4. Discussion of the relative incidence found with the nitrite induction test].
Topics: Headache; Humans; Italy; Migraine Disorders; Nitrites; Nitroglycerin | 1968 |