nitrogen-dioxide and Proteinuria

nitrogen-dioxide has been researched along with Proteinuria* in 2 studies

Other Studies

2 other study(ies) available for nitrogen-dioxide and Proteinuria

Article	Year
Endogenous nitric oxide synthesis determines sensitivity to the pressor effect of salt. Kidney international, 1994, Volume: 46, Issue:1 Endogenous nitric oxide plays an important role in modulation of renal hemodynamics and sodium handling, with increased nitric oxide production inducing renal vasodilation and natriuresis. In the normal rat, nitric oxide activity increases as an adaptive response to increased dietary salt intake, perhaps facilitating natriuresis and thus blood pressure homeostasis. We hypothesized that impaired nitric oxide synthetic ability would result in sensitivity to the pressor effects of high dietary salt intake. Four groups of normal Sprague-Dawley rats were observed for eight weeks: Control, 0.4% NaCl chow and tap water; Salt, 4% NaCl chow and tap water; NAME, 0.4% NaCl chow and water containing the nitric oxide synthase inhibitor, L-nitro-arginine-methylester; Salt+NAME, 4% NaCl chow and water containing L-nitro-arginine-methylester. Compared to Controls, Salt rats demonstrated a significant increase in urinary excretion rate of the stable nitric oxide metabolites, NO2 and NO3, and had no increase in blood pressure. Furthermore, Salt rats had no functional or structural evidence of renal injury. In contrast, Salt+NAME rats demonstrated a significantly higher blood pressure than NAME rats, and urinary NO2 and NO3 excretion rate did not increase despite high salt intake. After eight weeks, Salt+NAME rats had significantly impaired renal function and proteinuria. We conclude that adaptive changes in endogenous NO production play a critical role in sodium and blood pressure homeostasis. Furthermore, impaired nitric oxide synthase activity may be a pathogenetic factor in the development of salt-sensitive hypertension. Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Hypertension; Kidney Glomerulus; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitrogen Dioxide; Proteinuria; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary	1994
Proteinuria in guinea pigs exposed to 0.5 ppm nitrogen dioxide. Archives of environmental health, 1974, Volume: 28, Issue:6 Topics: Albuminuria; Animals; Atmosphere Exposure Chambers; Electrophoresis, Disc; Environmental Exposure; Guinea Pigs; Methods; Nitrogen Dioxide; Proteinuria; Specific Gravity; Time Factors	1974

Article

Year

Endogenous nitric oxide synthesis determines sensitivity to the pressor effect of salt.

Kidney international, 1994, Volume: 46, Issue:1

Endogenous nitric oxide plays an important role in modulation of renal hemodynamics and sodium handling, with increased nitric oxide production inducing renal vasodilation and natriuresis. In the normal rat, nitric oxide activity increases as an adaptive response to increased dietary salt intake, perhaps facilitating natriuresis and thus blood pressure homeostasis. We hypothesized that impaired nitric oxide synthetic ability would result in sensitivity to the pressor effects of high dietary salt intake. Four groups of normal Sprague-Dawley rats were observed for eight weeks: Control, 0.4% NaCl chow and tap water; Salt, 4% NaCl chow and tap water; NAME, 0.4% NaCl chow and water containing the nitric oxide synthase inhibitor, L-nitro-arginine-methylester; Salt+NAME, 4% NaCl chow and water containing L-nitro-arginine-methylester. Compared to Controls, Salt rats demonstrated a significant increase in urinary excretion rate of the stable nitric oxide metabolites, NO2 and NO3, and had no increase in blood pressure. Furthermore, Salt rats had no functional or structural evidence of renal injury. In contrast, Salt+NAME rats demonstrated a significantly higher blood pressure than NAME rats, and urinary NO2 and NO3 excretion rate did not increase despite high salt intake. After eight weeks, Salt+NAME rats had significantly impaired renal function and proteinuria. We conclude that adaptive changes in endogenous NO production play a critical role in sodium and blood pressure homeostasis. Furthermore, impaired nitric oxide synthase activity may be a pathogenetic factor in the development of salt-sensitive hypertension.

Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Hypertension; Kidney Glomerulus; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitrogen Dioxide; Proteinuria; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary

1994

Proteinuria in guinea pigs exposed to 0.5 ppm nitrogen dioxide.

Archives of environmental health, 1974, Volume: 28, Issue:6

Topics: Albuminuria; Animals; Atmosphere Exposure Chambers; Electrophoresis, Disc; Environmental Exposure; Guinea Pigs; Methods; Nitrogen Dioxide; Proteinuria; Specific Gravity; Time Factors

1974