nitrogen-dioxide and Mucocutaneous-Lymph-Node-Syndrome

Kawasaki disease (KD) is the most common form of acquired pediatric cardiac disease in the developed world. However, its etiology is still unclear. Epidemiological studies have shown that air pollution is a plausible risk factor in stimulating oxidative stress, inducing inflammation and causing autoimmune diseases. This study aims to assess the connections between prenatal and early life air pollution exposure to the incidence of KD. The main data source of this nationwide longitudinal study was the National Health Insurance Research Database (NHIRD) of Taiwan. NHIRD was linked with Taiwan Maternal and Child Health Database to establish the link between mothers and children. In total, 4192 KD cases involving children under 6 years of age were identified between January 2004 and December 2010. Children in the control group were randomly selected at a 1:4 ratio and matched using their age and index year. Integrated data for the air pollutants were obtained from 71 Environmental Protection Agency monitoring stations across Taiwan. Patients who had main admission diagnosis of KD and subsequently received intravenous immunoglobulin treatment were defined as incidence cases. Ambient exposure, including pollutant standards index (PSI), carbon monoxide (CO), nitric oxide (NO), nitric dioxide (NO

Topics: Air Pollutants; Air Pollution; Child, Preschool; Environmental Exposure; Female; Humans; Incidence; Longitudinal Studies; Mucocutaneous Lymph Node Syndrome; Nitric Oxide; Nitrogen Dioxide; Nitrogen Oxides; Ozone; Particulate Matter; Pregnancy

Kawasaki disease (KD) is an acute and multi-systemic vasculitis that occurs predominantly in infants and young children. Although the etiological agent of KD remains unclear, limited studies have reported that windborne environmental factors may trigger KD.. We conducted a time-stratified case-crossover study to assess the associations between air pollutants and KD in Taiwan.. We identified children < 5 years old with a diagnosis of KD from the Longitudinal Health Insurance Database 2000 (LHID2000) between 2000 and 2010. We obtained data regarding carbon monoxide (CO), nitrogen dioxide (NO. We identified 695 KD hospital admissions during the study period. An IQR increase (28.73 ppb) of O. Our results provide new evidence that exposure to O

Topics: Air Pollutants; Air Pollution; Carbon Monoxide; Child, Preschool; Environmental Exposure; Female; Hospitalization; Humans; Infant; Infant, Newborn; Male; Mucocutaneous Lymph Node Syndrome; Nitrogen Dioxide; Odds Ratio; Ozone; Particulate Matter; Seasons; Sulfur Dioxide; Taiwan