nitrogen-dioxide and Migraine-Disorders

Migraine is a complex neurological disorder with a high disability rate. Although the precipitating factors of migraine remain unclear, previous studies suggest that when there is excess nitrogen dioxide (NO

Topics: Animals; Migraine Disorders; Nitrogen Dioxide; Rats; Reactive Oxygen Species

Migraine is a common recurrent headache disorder affecting 14% American adults. Although weather and air pollution are often reported by patients with migraine as precipitating factors, previous studies have had mixed results.. We prospectively collected migraine headache onset data using electronic questionnaires from 98 adults with episodic migraine in the Greater Boston area (2016-2017). Each participant was followed for an average of 45 days for a total of 4406 days of observation. Temperature, relative humidity, and barometric pressure data were obtained from local weather station. Daily average fine particulate matter, daily maximum 1-hour sulfur dioxide, daily maximum 1-hour nitrogen dioxide, daily maximum 8-hour ozone, and daily maximum 8-hour carbon monoxide from local air pollution monitors. We conducted a repeated measures analysis using fixed effects logistic regression models. In the models we adjusted for day of week, a natural cubic spline term of day of the year with 4 degrees of freedom, and a participant identifier. We additionally adjusted for linear terms of temperature and relative humidity in the air pollution analyses. We also applied logistic regression models with generalized estimating equation (GEE) and autoregressive correlation structure in the sensitivity analysis.. The mean age was 35 years and 88% were women. Mean temperature was 56.9 °F, relative humidity 67.3%, and fine particulate matter 7.3 μg/m. We found that higher relative humidity was associated with higher odds of migraine headache onset in warm season, and traffic-related gaseous pollutants may be associated with higher odds of migraine headache onset in cold season.

Topics: Adult; Air Pollutants; Air Pollution; Carbon Monoxide; Environmental Monitoring; Female; Headache; Humans; Male; Massachusetts; Middle Aged; Migraine Disorders; Nitrogen Dioxide; Ozone; Particulate Matter; Risk Factors; Seasons; Sulfur Dioxide; Vehicle Emissions; Weather; Young Adult

The authors performed a time-series analysis to test the association between air pollution and daily numbers of hospitalizations for headache in 7 Chilean urban centers during the period 2001-2005. Results were adjusted for day of the week and humidex. Three categories of headache-migraine, headache with cause specified, and headache not otherwise specified-were all associated with air pollution. Relative risks for migraine associated with interquartile-range increases in specific air pollutants were as follows: 1.11 (95% confidence interval (CI): 1.06, 1.17) for a 1.15-ppm increase in carbon monoxide; 1.11 (95% CI: 1.06, 1.17) for a 28.97-microg/m(3) increase in nitrogen dioxide; 1.10 (95% CI: 1.04, 1.17) for a 6.20-ppb increase in sulfur dioxide; 1.17 (95% CI: 1.08, 1.26) for a 69.51-ppb increase in ozone; 1.11 (95% CI: 1.00, 1.19) for a 21.51-microg/m(3) increase in particulate matter less than 2.5 mum in aerodynamic diameter (PM(2.5)); and 1.10 (95% CI: 1.04, 1.15) for a 37.79-microg/m(3) increase in particulate matter less than 10 mum in aerodynamic diameter (PM(10)). There was no significant effect modification by age, sex, or season. The authors conclude that air pollution appears to increase the risk of headache in Santiago Province. If the relation is causal, the morbidity associated with headache should be considered when estimating the burden of illness and costs associated with poor air quality.

Topics: Air Pollutants; Air Pollution; Carbon Monoxide; Chile; Female; Headache; Hospitalization; Humans; Male; Middle Aged; Migraine Disorders; Nitrogen Dioxide; Ozone; Particulate Matter; Risk Factors; Sulfur Dioxide; Urban Health