nitrogen-dioxide and Liver-Diseases

With the generalized linear model and natural splines (ns), we examined the association between outdoor air pollutants and daily morbidity for diabetes and liver disease stratified by sexes and ages based on 4 years of daily data (2008-2011) in Tianjin, China. Season effects of air pollutants including particulate matter (PM), sulfur dioxide (SO2), and nitrogen dioxide (NO2) were also investigated. An increase of 10 μg/m(3) in a 2-day average concentrations of particulate matter with diameters of 10 μm or less (PM10), SO2, and NO2 corresponds to increases in diabetes morbidity of 0.39 % (95 % confidence interval (CI), -0.42-1.12), 0.15 % (95 % CI, -0.25-0.54), and 1.22 % (95 % CI, 0.51-2.96), respectively. As for liver morbidity, the increases were -0.84 % (95 % CI, -2.33-0.62), 0.90 % (95 % CI, 0.50-1.74), and 1.10 % (95 % CI, -2.58-4.78), respectively. The effects were stronger in the cool season than those in the warm season; females and the elderly were generally more vulnerable to outdoor air pollution. This study possesses scientific implications and instructional significance for local environmental standards and medical policymaking.

Topics: Adolescent; Adult; Age Distribution; Aged; Air Pollutants; Air Pollution; Child; Child, Preschool; China; Diabetes Mellitus; Female; Humans; Infant; Infant, Newborn; Liver Diseases; Male; Middle Aged; Morbidity; Nitrogen Dioxide; Particulate Matter; Risk Assessment; Seasons; Sex Distribution; Sulfur Dioxide; Young Adult

Male Sprague-Dawley rats were treated ip with beta-naphthoflavone (BNF, 40 mg/kg/day) in dimethylsulfoxide (DMSO, 26.7 mg BNF/ml) for three days. At 24 hr after the pretreatment DMSO (3.0 ml/kg), phenanthrene (150 mg/kg), ozonized or nitrated products of phenanthrene (150 mg/kg), pyrene (150 mg/kg), or ozonized or nitrated products of pyrene (150 mg/kg) were injected ip. Phenanthrene, pyrene, and their ozonized or nitrated products were dissolved in DMSO (50 mg/ml). No increase in the level of aspartate aminotransferase (AST), alanine aminotransferase (ALT) or sorbitol dehydrogenase (SDH) was seen in the pretreated rats 48 hr after the treatment. This is in contrast to what was seen in previous work without the BNF pretreatment. BNF pretreatment induced a small but significant increase in gamma-glutamyl transpeptidase (GGTP) levels. No treatment group receiving BNF differed from another with respect to GGTP. A decrease in lactate dehydrogenase (LDH) levels was noted in the nitro-PAH treatment groups; the same phenomenon was observed earlier in rats treated with nitro-PAH without BNF treatment. These results suggest that the mixed-function oxidase systems specifically induced by BNF have a protective effect against the hepatotoxicity of the oxonized or nitrated products of phenanthrene and pyrene.

Topics: Animals; Benzoflavones; beta-Naphthoflavone; Chemical and Drug Induced Liver Injury; Flavonoids; L-Lactate Dehydrogenase; Liver Diseases; Male; Nitrogen Dioxide; Ozone; Phenanthrenes; Pyrenes; Rats; Rats, Inbred Strains