nitrogen-dioxide and Crohn-Disease

Epidemiological evidence regarding the associations between long-term exposure to air pollution and risk of incident inflammatory bowel disease (IBD) is scant.. We examined the associations of various specific air pollutants with the risk of incident ulcerative colitis and Crohn's disease, two subtypes of IBD, among middle and old aged adults in the UK. We also explored potential susceptible subgroups.. We used data from the UK Biobank study. Information on air pollution, including PM. After a median follow-up of 11.7 years, 1872 incident ulcerative colitis and 865 incident Crohn's disease cases were identified among 455,210 IBD-free participants. HRs (95% CIs) of ulcerative colitis associated with each 1 interquartile range (IQR) increase in PM. Long-term exposure to various air pollutants was associated with the risk of incident ulcerative colitis but not Crohn's disease, highlighting the importance of developing environmental health strategy to reduce the burden of ulcerative colitis.

Topics: Adult; Air Pollutants; Air Pollution; Colitis, Ulcerative; Crohn Disease; Environmental Exposure; Humans; Inflammatory Bowel Diseases; Middle Aged; Nitrogen Dioxide; Particulate Matter