nitrogen-dioxide and Abortion--Spontaneous

Air pollution and previous abortion have been reported to be related to preterm birth (PTB). But rare study examined the effect of air pollution on PTB risk among mothers with previous abortion.. To estimate the effect of air pollution on PTB and the potential effect modification of previous abortion on such an association in rural part of Henan province (China).. Based on National Free Preconception Health Examination Project (NFPHEP), information from the medical records of 57,337 mothers with previous abortion were obtained. An inverse distance-weighted model was used to estimate exposure levels of air pollutants. The effect of air pollution on the risk of PTB was estimated with a multiple logistic regression model. Stratified and interaction analyses were undertaken to explore the potential effect modification of previous abortion on this association.. The risk of PTB was positively associated with exposure to levels of nitrogen dioxide (NO. The risk of PTB was positively associated with levels of NO

Topics: Abortion, Induced; Abortion, Spontaneous; Air Pollutants; Air Pollution; China; Female; Humans; Infant, Newborn; Maternal Exposure; Nitrogen Dioxide; Particulate Matter; Pregnancy; Premature Birth

Accumulating evidence suggests that air pollution increases pregnancy loss; however, most previous studies have focused on case identification from medical records, which may underrepresent early pregnancy losses. Our objective was to investigate the association between acute and chronic exposure to ambient air pollution and time to pregnancy loss among women undergoing assisted reproductive technologies (ART) who are closely followed throughout early pregnancy. We included 275 women (345 human chorionic gonadotropin (hCG)-confirmed pregnancies) undergoing ART at a New England academic fertility center. We estimated daily nitrogen dioxide (NO

Topics: Abortion, Spontaneous; Air Pollutants; Air Pollution; Environmental Exposure; Female; Humans; New England; Nitrogen Dioxide; Ozone; Particulate Matter; Pregnancy

Traffic-related air pollution has been linked to multiple adverse pregnancy outcomes. However, few studies have examined pregnancy loss, targeting losses identified by hospital records, a large limitation as it does not capture events not reported to the medical system.. We used a novel variation of the time-series design to determine the association, and identify the critical window of vulnerability, between week-to-week traffic-related air pollution and conceptions resulting in live births, using nitrogen dioxide (NO2) as a traffic emissions tracer. We used information from all live births recorded at Beth Israel Deaconess Medical Center in Boston, MA (2000-2013) and all live births in Tel Aviv District, Israel (2010-2013).. In Boston (68,969 live births), the strongest association was during the 15th week of gestation; for every 10 ppb of NO2 increase during that week, we observed a lower rate of live births (rate ratio [RR] = 0.87; 95% confidence interval [CI], 0.78, 0.97), using live birth-identified conceptions to infer pregnancy losses. In the Tel Aviv District (95,053 live births), the strongest estimate was during the 16th gestational week gestation (RR = 0.82; 95% CI, 0.76, 0.90 per 10 ppb of NO2).. Using weekly conceptions ending in live birth rather than identified pregnancy losses, we comprehensively analyzed the relationship between air pollution and all pregnancy loss throughout gestation. The observed results, with remarkable similarity in two independent locations, suggest that higher traffic-related air pollution levels are associated with pregnancy loss, with strongest estimates between the 10th and 20th gestational weeks.

Topics: Abortion, Spontaneous; Boston; Environmental Monitoring; Female; Humans; Israel; Live Birth; Nitrogen Dioxide; Pregnancy; Retrospective Studies; Traffic-Related Pollution

To investigate the relationship between acute exposure to air pollutants and spontaneous pregnancy loss.. Case-crossover study from 2007 to 2015.. An academic emergency department in the Wasatch Front area of Utah.. A total of 1,398 women who experienced spontaneous pregnancy loss events.. None.. Odds of spontaneous pregnancy loss.. We found that a 10-ppb increase in 7-day average levels of nitrogen dioxide was associated with a 16% increase in the odds of spontaneous pregnancy loss (odds ratio [OR] = 1.16; 95% confidence interval [CI] 1.01-1.33; P=.04). A 10-μg/m. We found that short-term exposure to elevated levels of air pollutants was associated with higher risk for spontaneous pregnancy loss.

Topics: Abortion, Spontaneous; Adolescent; Adult; Air Pollutants; Case-Control Studies; Child; Cross-Over Studies; Emergency Service, Hospital; Female; Humans; Inhalation Exposure; Middle Aged; Nitrogen Dioxide; Particle Size; Particulate Matter; Pregnancy; Risk Assessment; Risk Factors; Time Factors; Utah; Young Adult

Air pollution is a major health challenge worldwide and has previously been strongly associated with adverse reproductive health. This study aimed to examine the association between spontaneous abortion and seasonal variation of air pollutants in Ulaanbaatar, Mongolia.. Monthly average O3, SO2, NO2, CO, PM10 and PM2.5 levels were measured at Mongolian Government Air Quality Monitoring stations. The medical records of 1219 women admitted to the hospital due to spontaneous abortion between 2009-2011 were examined retrospectively. Fetal deaths per calendar month from January-December, 2011 were counted and correlated with mean monthly levels of various air pollutants by means of regression analysis.. Regression of ambient pollutants against fetal death as a dose-response toxicity curve revealed very strong dose-response correlations for SO2 r > 0.9 (p < 0.001) while similarly strongly significant correlation coefficients were found for NO2 (r > 0.8), CO (r > 0.9), PM10 (r > 0.9) and PM2.5 (r > 0.8), (p < 0.001), indicating a strong correlation between air pollution and decreased fetal wellbeing.. The present study identified alarmingly strong statistical correlations between ambient air pollutants and spontaneous abortion. Further studies need to be done to examine possible correlations between personal exposure to air pollutants and pregnancy loss.

Topics: Abortion, Spontaneous; Adolescent; Adult; Air Pollutants; Air Pollution; Carbon Monoxide; Female; Fetal Death; Humans; Mongolia; Nitrogen Dioxide; Ozone; Particulate Matter; Pregnancy; Retrospective Studies; Seasons; Sulfur Dioxide; Young Adult