Page last updated: 2024-10-19

nitrites and Stomach Ulcer

nitrites has been researched along with Stomach Ulcer in 38 studies

Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)

Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).

Research Excerpts

ExcerptRelevanceReference
"The modulation of the cyclooxygenase-independent pathway by the green tea-derived polyphenol, epigallocatechin gallate (EGCG) during its healing action against indomethacin (IND)-induced stomach ulceration in mice was investigated."7.77Role of the COX-independent pathways in the ulcer-healing action of epigallocatechin gallate. ( Adhikary, B; Bandyopadhyay, SK; Chattopadhyay, S; Yadav, SK, 2011)
"The role of the ariginine-metabolism in the healing action of the Piper betle phenol, allylpyrocatechol (APC) and omeprazole against indomethacin-induced stomach ulceration in mouse was investigated."7.75The gastric ulcer-healing action of allylpyrocatechol is mediated by modulation of arginase metabolism and shift of cytokine balance. ( Adhikary, B; Bandyopadhyay, SK; Chattopadhyay, S; Maity, B; Yadav, SK, 2009)
"The modulation of the cyclooxygenase-independent pathway by black tea (BT) and its constituent theaflavins (TFs) during their healing action against indomethacin-induced stomach ulceration in mice was investigated."3.77Black tea and theaflavins suppress various inflammatory modulators and i-NOS mediated nitric oxide synthesis during gastric ulcer healing. ( Adhikary, B; Bandyopadhyay, SK; Chand, S; Chattopadhyay, S; Yadav, SK, 2011)
"The modulation of the cyclooxygenase-independent pathway by the green tea-derived polyphenol, epigallocatechin gallate (EGCG) during its healing action against indomethacin (IND)-induced stomach ulceration in mice was investigated."3.77Role of the COX-independent pathways in the ulcer-healing action of epigallocatechin gallate. ( Adhikary, B; Bandyopadhyay, SK; Chattopadhyay, S; Yadav, SK, 2011)
"The role of the ariginine-metabolism in the healing action of the Piper betle phenol, allylpyrocatechol (APC) and omeprazole against indomethacin-induced stomach ulceration in mouse was investigated."3.75The gastric ulcer-healing action of allylpyrocatechol is mediated by modulation of arginase metabolism and shift of cytokine balance. ( Adhikary, B; Bandyopadhyay, SK; Chattopadhyay, S; Maity, B; Yadav, SK, 2009)
"Lead increases the formation of gastric ulcers by interfering with the oxidative metabolism in the stomach."3.74Lead exposure increases oxidative stress in the gastric mucosa of HCl/ethanol-exposed rats. ( Adaramoye, OA; Adeniyi, OS; Erigbali, PP; Olaleye, SB, 2007)
"Nicotine intensifies experimental gastric ulceration by reducing gastric mucosal blood flow (GMBF) and mucus."3.71Reversal of the gastric effects of nicotine by nitric oxide donor treatment. ( Hou, DQ; Korsten, MA; Ma, JJ; Zhang, QB, 2001)
" The influence of hyperammonemia (produced by the continuous intraperitoneal infusion of ammonium acetate for 6 days) on stress-induced gastric ulcer formation was investigated in conscious rats."3.70Hyperammonemia reduces water immersion--restraint stress gastric ulcers in rats. ( Ishihara, T; Shoji, Y; Takada, T; Takeyama, N; Tanaka, T; Uedono, Y, 1998)
" The diclofenac derivative, 'nitrofenac', was examined in terms of its ability to induce acute gastric erosions and chronic-type gastric ulcers in rats and rabbits, respectively."3.69A diclofenac derivative without ulcerogenic properties. ( Cicala, C; Cirino, G; Grisham, M; McKnight, W; Reuter, B; Wallace, JL, 1994)
" To investigate the mechanism of action, conducted assays of antioxidant activity, measured the dosage of inflammatory cytokines, quantified mucus, treated with inhibitors (IND, L-NAME, glibenclamide, and yohimbine), performed histopathological analysis, and measured gastric acid secretion."2.44Antiulcer activity and mechanism of action of the hydroethanolic extract of leaves of Terminalia argentea Mart. In different in vivo and in vitro experimental models. ( Arunachalam, K; Damazo, AS; Figueiredo, FF; Martins, DTO; Muller, JAI; Oliveira, DM; Serio, BFD; Silva, MJD; Venturini, CL, 2024)
"Cholestasis is associated with NO overproduction."1.31The role of the interaction between endogenous opioids and nitric oxide in the pathophysiology of ethanol-induced gastric damage in cholestatic rats. ( Akbari, MR; Dehpour, AR; Homayounfar, H; Mani, AR; Nahavandi, A, 2001)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19908 (21.05)18.7374
1990's5 (13.16)18.2507
2000's14 (36.84)29.6817
2010's9 (23.68)24.3611
2020's2 (5.26)2.80

Authors

AuthorsStudies
Khalaf, HM1
Ahmed, SM1
Welson, NN1
Abdelzaher, WY1
Venturini, CL1
Damazo, AS1
Silva, MJD1
Muller, JAI1
Oliveira, DM1
Figueiredo, FF1
Serio, BFD1
Arunachalam, K1
Martins, DTO1
Boutemine, IM1
Amri, M1
Amir, ZC1
Fitting, C1
Mecherara-Idjeri, S1
Layaida, K1
Sennoun, N1
Berkane, S1
Cavaillon, JM1
Touil-Boukoffa, C1
Balan, T1
Sani, MH1
Mumtaz Ahmad, SH1
Suppaiah, V1
Mohtarrudin, N1
Zakaria, ZA1
Díaz-Rivas, JO1
Herrera-Carrera, E1
Gallegos-Infante, JA1
Rocha-Guzmán, NE1
González-Laredo, RF1
Moreno-Jiménez, MR1
Ramos-Gómez, M1
Reynoso-Camacho, R1
Larrosa-Pérez, M1
Gallegos-Corona, MA1
Morsy, MA1
Fouad, AA1
Yadav, SK3
Adhikary, B3
Maity, B1
Bandyopadhyay, SK3
Chattopadhyay, S3
Vasanthkumar, M1
Parameswari, RP1
Vijaya Kumar, V1
Sangeetha, MK1
Gayathri, V1
Balaji Raghavendran, H1
Chamundeeswari, D1
Vasanthi, HR1
Girard, P1
Coppé, MC1
Pansart, Y1
Gillardin, JM1
Chand, S1
Rocha, NF1
Oliveira, GV1
Araújo, FY1
Rios, ER1
Carvalho, AM1
Vasconcelos, LF1
Macêdo, DS1
Soares, PM1
Sousa, DP1
Sousa, FC1
Jin, L1
Qin, L1
Xia, D1
Liu, X1
Fan, Z1
Zhang, C1
Gu, L1
He, J1
Ambudkar, IS1
Deng, D1
Wang, S1
Liu, MY1
Chiang, JP1
Hsu, DZ1
Deng, JF1
Engel, LS1
Chow, WH1
Vaughan, TL1
Gammon, MD1
Risch, HA1
Stanford, JL1
Schoenberg, JB1
Mayne, ST1
Dubrow, R1
Rotterdam, H1
West, AB1
Blaser, M1
Blot, WJ1
Gail, MH1
Fraumeni, JF1
Demirbilek, S1
Gürses, I1
Sezgin, N1
Karaman, A1
Gürbüz, N1
Björne, H1
Govoni, M1
Törnberg, DC1
Lundberg, JO1
Weitzberg, E1
Ismail, HA1
Khalifa, MM1
Hassan, MK1
Ashour, OM1
Baggio, CH1
Freitas, CS1
Otofuji, Gde M1
Cipriani, TR1
Souza, LM1
Sassaki, GL1
Iacomini, M1
Marques, MC1
Mesia-Vela, S1
Olaleye, SB1
Adaramoye, OA1
Erigbali, PP1
Adeniyi, OS1
Ruddell, WS2
Eisenbrand, G1
Adam, B1
Peter, M2
Malfertheiner, P1
Schlag, P3
Reed, PI1
Summers, K1
Smith, PL2
Walters, CL3
Bartholomew, BA1
Hill, MJ3
Venitt, S1
House, FR1
Hornig, DH1
Bonjour, JP1
Böckler, R2
Meyer, H1
Wallace, JL2
Reuter, B2
Cicala, C2
McKnight, W2
Grisham, MB1
Cirino, G2
Grisham, M1
Ishihara, T1
Takada, T1
Shoji, Y1
Uedono, Y1
Takeyama, N1
Tanaka, T1
Takeuchi, K1
Suzuki, K1
Yamamoto, H1
Araki, H1
Mizoguchi, H1
Ukawa, H1
Pshennikova, MG2
Smirin, BV2
Bondarenko, ON1
Malyshev, IIu2
Manukhina, EB2
Ma, JJ1
Hou, DQ1
Zhang, QB1
Korsten, MA1
Nahavandi, A1
Mani, AR1
Homayounfar, H1
Akbari, MR1
Dehpour, AR1
Shiotani, A1
Yamaoka, Y1
El-Zimaity, HM1
Saeed, MA1
Qureshi, WA1
Graham, DY1
Popkova, EV1
Bondarenko, NA1
Shimkovich, MV1
Bone, ES1
Blendis, LM1
Kitagawa, H1
Takeda, F1
Kohei, H1
Stockbrügger, RW1
Cronstedt, J1
Dotevall, G1
Hellner, L1
Hoffmann, P1
Hradsky, M1
Jaup, BH1
Seeberg, S1
Thomas, JM1
Misiewicz, JJ1
Cook, AR1
Forster, JK1
Martin, LE1
Woodings, DF1

Trials

1 trial available for nitrites and Stomach Ulcer

ArticleYear
The intragastric milieu during gastric ulcer treatment with pirenzepine 50 mg b.i.d. or cimetidine 400 mg b.i.d.
    Zeitschrift fur Gastroenterologie, 1988, Volume: 26, Issue:11

    Topics: Adult; Aged; Bacteria; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Female; Fungi; Gas

1988

Other Studies

37 other studies available for nitrites and Stomach Ulcer

ArticleYear
Rivastigmine ameliorates indomethacin experimentally induced gastric mucosal injury via activating α7nAChR with inhibiting oxidative stress and apoptosis.
    Journal of biochemical and molecular toxicology, 2022, Volume: 36, Issue:10

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Apoptosis; Caspase 3; Cholinergic Agents; Glutathi

2022
Antiulcer activity and mechanism of action of the hydroethanolic extract of leaves of Terminalia argentea Mart. In different in vivo and in vitro experimental models.
    Journal of ethnopharmacology, 2024, Jan-10, Volume: 318, Issue:Pt B

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Cytokines; Ethanol; Indomethacin; Mice; Models, Theoretica

2024
Gastro-protective, therapeutic and anti-inflammatory activities of Pistacia lentiscus L. fatty oil against ethanol-induced gastric ulcers in rats.
    Journal of ethnopharmacology, 2018, Oct-05, Volume: 224

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Ethanol; Gastric Mucosa; Interleukin-6; Lethal

2018
Antioxidant and anti-inflammatory activities contribute to the prophylactic effect of semi-purified fractions obtained from the crude methanol extract of Muntingia calabura leaves against gastric ulceration in rats.
    Journal of ethnopharmacology, 2015, Apr-22, Volume: 164

    Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antioxidants; Biphenyl Compounds; Cell Line; C

2015
Gastroprotective potential of Buddleja scordioides Kunth Scrophulariaceae infusions; effects into the modulation of antioxidant enzymes and inflammation markers in an in vivo model.
    Journal of ethnopharmacology, 2015, Jul-01, Volume: 169

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Biomarkers; Buddleja; Down-Regulation; Gastric Mucosa; Ind

2015
Mechanisms of gastroprotective effect of eugenol in indomethacin-induced ulcer in rats.
    Phytotherapy research : PTR, 2008, Volume: 22, Issue:10

    Topics: Animals; Eugenol; Gastric Mucosa; Glyburide; Indomethacin; Male; Malondialdehyde; Nitrites; Rats; Ra

2008
The gastric ulcer-healing action of allylpyrocatechol is mediated by modulation of arginase metabolism and shift of cytokine balance.
    European journal of pharmacology, 2009, Jul-01, Volume: 614, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents; Arginase; Arginine; Catechols; Cytokines; Gene Expression Regulat

2009
Anti-ulcer role of herbomineral Siddha drug - Thamira parpam on experimentally induced gastric mucosal damage in rats.
    Human & experimental toxicology, 2010, Volume: 29, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Body Weight; Cytoprotection; Disease Models, Anim

2010
Gastroprotective effect of Saccharomyces boulardii in a rat model of ibuprofen-induced gastric ulcer.
    Pharmacology, 2010, Volume: 85, Issue:3

    Topics: Animals; Body Weight; Cytoprotection; Disease Models, Animal; Gastric Mucosa; Ibuprofen; Male; Nitra

2010
Black tea and theaflavins suppress various inflammatory modulators and i-NOS mediated nitric oxide synthesis during gastric ulcer healing.
    Free radical research, 2011, Volume: 45, Issue:7

    Topics: Animals; Biflavonoids; Catechin; Cell Adhesion Molecules; Immunoblotting; Indomethacin; Mice; Nitric

2011
Role of the COX-independent pathways in the ulcer-healing action of epigallocatechin gallate.
    Food & function, 2011, Volume: 2, Issue:6

    Topics: Animals; Anti-Ulcer Agents; Catechin; Gene Expression Regulation; Intercellular Adhesion Molecule-1;

2011
(-)-α-Bisabolol-induced gastroprotection is associated with reduction in lipid peroxidation, superoxide dismutase activity and neutrophil migration.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2011, Nov-20, Volume: 44, Issue:4

    Topics: Acetylcysteine; Animals; Catalase; Cell Movement; Ethanol; Gastric Mucosa; Lipid Peroxidation; Male;

2011
Active secretion and protective effect of salivary nitrate against stress in human volunteers and rats.
    Free radical biology & medicine, 2013, Volume: 57

    Topics: Adult; Animals; Female; Gastric Juice; Gastric Mucosa; Humans; Male; Middle Aged; Nitrates; Nitrites

2013
Abamectin attenuates gastric mucosal damage induced by ethanol through activation of vagus nerve in rats.
    Alcohol (Fayetteville, N.Y.), 2003, Volume: 30, Issue:1

    Topics: Animals; Anthelmintics; Central Nervous System Depressants; Ethanol; Gastric Mucosa; Gastrointestina

2003
Population attributable risks of esophageal and gastric cancers.
    Journal of the National Cancer Institute, 2003, Sep-17, Volume: 95, Issue:18

    Topics: Adenocarcinoma; Adult; Aged; Alcohol Drinking; Body Mass Index; Carcinoma, Squamous Cell; Cardia; Ca

2003
Protective effect of polyunsaturated phosphatidylcholine pretreatment on stress ulcer formation in rats.
    Journal of pediatric surgery, 2004, Volume: 39, Issue:1

    Topics: Animals; Catalase; Cold Temperature; Disease Models, Animal; Female; Gastric Mucosa; Male; Malondial

2004
Intragastric nitric oxide is abolished in intubated patients and restored by nitrite.
    Critical care medicine, 2005, Volume: 33, Issue:8

    Topics: Adult; Aged; Analysis of Variance; Female; Gastric Mucosa; Gastritis; Humans; In Vitro Techniques; I

2005
Insights in the mechanisms underlying the anti-ulcer activity of nicorandil.
    Die Pharmazie, 2007, Volume: 62, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Dinoprostone; Gastric Acid; Gastric Juice; Gastric Mucosa; Histamine; Hy

2007
Flavonoid-rich fraction of Maytenus ilicifolia Mart. ex. Reiss protects the gastric mucosa of rodents through inhibition of both H+,K+ -ATPase activity and formation of nitric oxide.
    Journal of ethnopharmacology, 2007, Sep-25, Volume: 113, Issue:3

    Topics: Acetic Acid; Animals; Female; Flavonoids; Gastric Acid; Gastric Juice; Gastric Mucosa; Glutathione;

2007
Lead exposure increases oxidative stress in the gastric mucosa of HCl/ethanol-exposed rats.
    World journal of gastroenterology, 2007, Oct-14, Volume: 13, Issue:38

    Topics: Animals; Catalase; Ethanol; Gastric Mucosa; Gene Expression Regulation, Enzymologic; Hydrochloric Ac

2007
Cimetidine, gastric pH, and nitrosation.
    Lancet (London, England), 1981, Apr-04, Volume: 1, Issue:8223

    Topics: Cimetidine; Guanidines; Humans; Hydrogen-Ion Concentration; Nitrites; Research Design; Stomach Ulcer

1981
Formation of nitrite in gastric juice of patients with various gastric disorders after ingestion of a standard dose of nitrate--a possible risk factor in gastric carcinogenesis.
    IARC scientific publications, 1984, Issue:57

    Topics: Duodenal Ulcer; Gastrectomy; Gastric Juice; Gastritis, Atrophic; Humans; Nitrates; Nitrites; Risk; S

1984
Effect of gastric surgery for benign peptic ulcer and ascorbic acid therapy on concentrations of nitrite and N-nitroso compounds in gastric juice.
    IARC scientific publications, 1984, Issue:57

    Topics: Adolescent; Adult; Aged; Ascorbic Acid; Female; Gastrectomy; Gastric Juice; Humans; Male; Middle Age

1984
An experimental study on bacterial colonization, nitrite and nitrosamine production in the operated stomach.
    Journal of cancer research and clinical oncology, 1983, Volume: 105, Issue:1

    Topics: Animals; Bacteria; Gastric Juice; Gastric Mucosa; Male; Nitrates; Nitrites; Nitrosamines; Rats; Rats

1983
Nitrite and nitrosamines in gastric juice: risk factors for gastric cancer?
    Scandinavian journal of gastroenterology, 1982, Volume: 17, Issue:1

    Topics: Atrophy; Duodenal Ulcer; Fasting; Gastric Juice; Gastric Mucosa; Gastritis; Humans; Hydrogen-Ion Con

1982
Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat.
    Gastroenterology, 1994, Volume: 107, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Flurbiprofen; Ketoprofen; Leukocyte

1994
A diclofenac derivative without ulcerogenic properties.
    European journal of pharmacology, 1994, May-23, Volume: 257, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Diclofenac; Gastric Mucosa; Inflam

1994
Hyperammonemia reduces water immersion--restraint stress gastric ulcers in rats.
    General pharmacology, 1998, Volume: 31, Issue:1

    Topics: Acetates; Animals; Enzyme Inhibitors; Immersion; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitr

1998
Cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal anti-inflammatory drugs and gastric mucosal responses.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 1998, Volume: 49, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Cyclooxygenase 2; Dinoprosto

1998
[Nitric oxide storage in rats of various genetic strains and its role in the antistressor effect of adaptation to hypoxia].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2000, Volume: 86, Issue:2

    Topics: Adaptation, Physiological; Animals; Blood Vessels; Male; Nitrates; Nitric Oxide; Nitrites; Oxygen; P

2000
Reversal of the gastric effects of nicotine by nitric oxide donor treatment.
    Digestion, 2001, Volume: 63, Issue:2

    Topics: Analysis of Variance; Animals; Blood Flow Velocity; Ethanol; Gastric Mucins; Gastric Mucosa; Isosorb

2001
The role of the interaction between endogenous opioids and nitric oxide in the pathophysiology of ethanol-induced gastric damage in cholestatic rats.
    Fundamental & clinical pharmacology, 2001, Volume: 15, Issue:3

    Topics: Alcohol Deterrents; Animals; Arginine; Bile Ducts; Cholestasis; Disease Models, Animal; Enzyme Inhib

2001
NSAID gastric ulceration: predictive value of gastric pH, mucosal density of polymorphonuclear leukocytes, or levels of IL-8 or nitrite.
    Digestive diseases and sciences, 2002, Volume: 47, Issue:1

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cell Count; Female; Gastric Acidity Determination; G

2002
[Catecholamines, nitrogen oxide, and resistivity to stressor lesions: effect of adaptation to hypoxia].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2002, Volume: 88, Issue:4

    Topics: Adaptation, Physiological; Altitude; Animals; Catecholamines; Corpus Striatum; Exploratory Behavior;

2002
Gastric-juice nitrite. A risk factor for cancer in the hypochlorhydric stomach?
    Lancet (London, England), 1976, Nov-13, Volume: 2, Issue:7994

    Topics: Achlorhydria; Carcinogens; Duodenal Ulcer; Enterobacteriaceae; Gastric Juice; Humans; Hydrogen-Ion C

1976
Effect of endothelium-derived relaxing factor on the gastric lesion induced by HCl in rats.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:3

    Topics: Acetylcholine; Animals; Drug Interactions; Electric Stimulation; Gastric Mucosa; Hemodynamics; Hydro

1990
Effects of one year's treatment with ranitidine and of truncal vagotomy on gastric contents.
    Gut, 1987, Volume: 28, Issue:6

    Topics: Adult; Aged; Bacteria; Duodenal Ulcer; Gastric Juice; Humans; Hydrogen-Ion Concentration; Male; Midd

1987