nitrites and Peripheral Arterial Diseases studies

Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)

Research Excerpts

Excerpt	Relevance	Reference
" Further studies evaluating longer-duration nitrite therapy and/or additional nitrite dosing strategies are warranted to more fully evaluate the therapeutic potential of nitrite therapy in peripheral vascular disease."	5.42	Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome. ( Bradley, JM; Brewster, LP; Calvert, JW; Chang, CC; Goodchild, TT; Islam, KN; Lefer, DJ; Pipinos, II; Polhemus, DJ; Tao, YX, 2015)
" The aim of this study was to analyse the effects of a single session of resistance exercise on blood flow, reactive hyperemia, plasma nitrite, and plasma malondialdehyde in patients with peripheral artery disease."	5.20	A session of resistance exercise increases vasodilation in intermittent claudication patients. ( Brasileiro-Santos, M; Correia, M; Forjaz, CL; Lima, A; Miranda, A; Ritti-Dias, R; Santos, A; Silva, A; Sobral Filho, D, 2015)
" Nitric oxide (NO) bioavailability is essential for vascular health and function."	2.76	Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. ( Allen, JD; Ham, KL; Johnson, JL; Kenjale, AA; Kraus, WE; Privette, G; Robbins, JL; Stabler, T; Vanbruggen, M; Yim, E, 2011)
" Further studies evaluating longer-duration nitrite therapy and/or additional nitrite dosing strategies are warranted to more fully evaluate the therapeutic potential of nitrite therapy in peripheral vascular disease."	1.42	Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome. ( Bradley, JM; Brewster, LP; Calvert, JW; Chang, CC; Goodchild, TT; Islam, KN; Lefer, DJ; Pipinos, II; Polhemus, DJ; Tao, YX, 2015)

Research

Studies (13)

Authors

Clinical Trials (10)

Trial Overview

Trial Outcomes

Change in Angiogenesis

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (15.38)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	10 (76.92)	24.3611
2020's	1 (7.69)	2.80

Authors	Studies
Piknova, B	3
Woessner, MN	3
de Zevallos, JO	3
Kraus, WE	5
VanBruggen, MD	4
Schechter, AN	3
Allen, JD	6
Woessner, M	1
Pieper, CF	1
Sloane, R	1
Gow, AJ	1
Wils, J	1
Djerada, Z	1
Roca, F	1
Duflot, T	1
Iacob, M	1
Remy-Jouet, I	1
Joannides, R	1
Bellien, J	1
Loffredo, L	1
Perri, L	1
Catasca, E	1
Pignatelli, P	1
Brancorsini, M	1
Nocella, C	1
De Falco, E	1
Bartimoccia, S	1
Frati, G	1
Carnevale, R	1
Violi, F	1
Lima, A	1
Ritti-Dias, R	1
Forjaz, CL	1
Correia, M	1
Miranda, A	1
Brasileiro-Santos, M	1
Santos, A	1
Sobral Filho, D	1
Silva, A	1
Polhemus, DJ	1
Bradley, JM	1
Islam, KN	1
Brewster, LP	1
Calvert, JW	1
Tao, YX	1
Chang, CC	1
Pipinos, II	1
Goodchild, TT	1
Lefer, DJ	1
Schneider, JY	1
Rothmann, S	1
Schröder, F	1
Langen, J	1
Lücke, T	1
Mariotti, F	1
Huneau, JF	1
Frölich, JC	1
Tsikas, D	1
Lima, AHRA	1
Correia, MA	1
Soares, AHG	1
Farah, BQ	1
Forjaz, CLM	1
Silva, AS	1
Brasileiro-Santos, MS	1
Santos, AC	1
Ritti-Dias, RM	1
Brix, M	1
Buschmann, EE	1
Zietzer, A	1
Jaurigue, JA	1
Li, L	1
Jungk, C	1
Buschmann, I	1
Janke, D	1
Hillmeister, P	1
Stabler, T	2
Kenjale, A	1
Ham, KL	2
Robbins, JL	2
Duscha, BD	1
Dobrosielski, DA	1
Annex, BH	1
Kenjale, AA	1
Johnson, JL	1
Vanbruggen, M	1
Privette, G	1
Yim, E	1
HUEBER, EF	1
THALER, H	1
WICK, E	1
SAMUELS, SS	1
PADERNACHT, ED	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Increased Plasma Nitrite, Tissue Oxygenation and Functional Changes in PAD[NCT01684930]	Phase 2	32 participants (Actual)	Interventional	2012-06-30	Completed
Dietary Nitrate to Augment Exercise Training Benefits in Subjects With Type II Diabetes (DM) and Peripheral Arterial Disease (PAD)[NCT01785524]	Phase 2	18 participants (Actual)	Interventional	2013-02-28	Completed
Effect of Dark Chocolate on Endothelial Function and Oxidative Stress in Patients With Peripheral Vascular Disease.[NCT01947712]	Phase 1/Phase 2	20 participants (Actual)	Interventional	2010-10-31	Completed
Dietary Nitrates for Heart Failure[NCT01682356]	Phase 1/Phase 2	126 participants (Anticipated)	Interventional	2012-01-31	Active, not recruiting
Nitrite Supplementation to Mitigate Fatigability and Increase Function in Long COVID Patients[NCT05618574]	Phase 3	40 participants (Anticipated)	Interventional	2023-12-01	Recruiting
Acute Effects of Beet Juice Consumption on Exercise Capacity in Heart Failure[NCT01946542]	Phase 1/Phase 2	2 participants (Actual)	Interventional	2014-02-28	Terminated (stopped due to Low enrollment)
Dietary Nitrate Supplementation and Thermoregulation During Exercise[NCT03506646]		10 participants (Anticipated)	Interventional	2018-09-05	Active, not recruiting
Strength Testing After Nitrate Delivery (STAND) in ICU Patients[NCT02293616]		25 participants (Actual)	Interventional	2015-06-30	Completed
The Effects of Oral Inorganic Nitrate Supplementation on Lower Limb Perfusion and Metabolism During Exercise in Patients With Peripheral Arterial Disease (PAD)[NCT05036213]	Phase 1	28 participants (Anticipated)	Interventional	2020-02-01	Recruiting
Acute Dietary Nitrate Supplementation to Improve Performance in Endurance Trained Athletes[NCT01384968]		20 participants (Actual)	Interventional	2011-07-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Gastrocnemious muscle biopsy will be performed to measure the number of capillaries per fibre as a marker of change in angiogenesis between groups (NCT01684930)
Timeframe: Baseline and 16 weeks

Change In Claudication Onset Time

Intervention	capillaries per fibrer (Mean)
BR Juice (Beet-It Stamina Shot) and Exercise Training	0.38
BR Juice Placebo and Exercise Training	0.26

Exercise capacity will be assessed using a maximal cardiopulmonary exercise (CPX) test with expired gas analysis, for determination of claudication onset time. (NCT01684930)
Timeframe: Baseline and 16 weeks

Change in Exercise Capacity: VO2peak (Maximal Oxygen Consumption)

Intervention	seconds (Mean)
BR Juice (Beet-It Stamina Shot) and Exercise Training	199.22
BR Juice Placebo and Exercise Training	48.58

Exercise capacity will be assessed using a maximal cardiopulmonary exercise (CPX) test with expired gas analysis, for determination of peak oxygen consumption, claudication onset time and peak walking time. (NCT01684930)
Timeframe: Baseline and 16 Weeks

Change in Functional Ability

Intervention	ml/kg/min (Mean)
BR Juice (Beet-It Stamina Shot) and Exercise Training	1.48
BR Juice Placebo and Exercise Training	0.23

Six-Minute Walk test. This test simple and practical assessment of functional capacity. The test measures the distance that a patient can walk on a flat, hard surface in a period of 6 minutes. The test is self-paced and assesses the submaximal level of functional capacity. The subjects choose their own intensity and are allowed to stop and rest if necessary during the test. (NCT01684930)
Timeframe: Baseline and 16 Weeks

Change In Time To Exhaustion

Intervention	feet (Mean)
BR Juice (Beet-It Stamina Shot) and Exercise Training	172.89
BR Juice Placebo and Exercise Training	95

Exercise capacity will be assessed using a maximal cardiopulmonary exercise (CPX) test with expired gas analysis, for determination of total time to exhaustion. (NCT01684930)
Timeframe: Baseline and 16 weeks

Change In Vascular Function (BAFMD)

Intervention	seconds (Mean)
BR Juice (Beet-It Stamina Shot) and Exercise Training	289.56
BR Juice Placebo and Exercise Training	254.92

Vascular Function is measured as Brachial artery flow-mediated dilation (BAFMD). BAFMD is a measure of change in artery diameter after a stimulus . (NCT01684930)
Timeframe: Baseline and 16 weeks

Change in Angiogenesis

Intervention	% dilation (Mean)
BR Juice (Beet-It Stamina Shot) and Exercise Training	-1.14
BR Juice Placebo and Exercise Training	-0.19

Gastrocnemious muscle biopsy will be performed to measure the number of capillaries per fibre as a marker of change in angiogenesis between groups. (NCT01785524)
Timeframe: Baseline and 16 weeks

Change in Exercise Capacity - Claudication Onset Time (COT)

Intervention	ratio of capillaries to muscle fibres (Mean)
BR Juice (Beet-It Stamina Shot) & Supervised Exercise Training	2

Exercise capacity will be assessed using a maximal cardiopulmonary exercise (CPX) test for determination of Claudication Onset Time (COT) (NCT01785524)
Timeframe: Baseline & 16 Weeks

Change in Exercise Capacity - Maximal Oxygen Capacity (VO2peak)

Intervention	seconds (Mean)
BR Juice (Beet-It Stamina Shot) & Supervised Exercise Training	189
BR Juice Placebo and Exercise Training	77.5

Exercise capacity will be assessed using a maximal cardiopulmonary exercise (CPX) test with expired gas analysis, for determination of peak oxygen consumption (NCT01785524)
Timeframe: Baseline & 16 Weeks

Change in Exercise Capacity - Time to Exhaustion (TTE)

Intervention	ml/kg/min (Mean)
BR Juice (Beet-It Stamina Shot) & Supervised Exercise Training	0.85
BR Juice Placebo and Exercise Training	-0.15

Exercise capacity will be assessed using a maximal cardiopulmonary exercise (CPX) test for determination of Time to Exhaustion (TTE) (NCT01785524)
Timeframe: Baseline & 16 Weeks

Change in Functional Ability

Intervention	seconds (Mean)
BR Juice (Beet-It Stamina Shot) & Supervised Exercise Training	196.25
BR Juice Placebo and Exercise Training	247.5

Change In Vascular Function

Intervention	feet (Mean)
BR Juice (Beet-It Stamina Shot) & Supervised Exercise Training	131
BR Juice Placebo and Exercise Training	47.5

Vascular Function will be measured as the Brachial artery flow-mediated dilation (BAFMD) (NCT01785524)
Timeframe: Baseline and 16 weeks

Article	Year
Beet the Best? Circulation research, 2018, 08-31, Volume: 123, Issue:6 Topics: Aged; Beta vulgaris; Biomarkers; Double-Blind Method; Exercise Therapy; Exercise Tolerance; Female;	2018
Beet the Best? Circulation research, 2018, 08-31, Volume: 123, Issue:6 Topics: Aged; Beta vulgaris; Biomarkers; Double-Blind Method; Exercise Therapy; Exercise Tolerance; Female;	2018
Beet the Best? Circulation research, 2018, 08-31, Volume: 123, Issue:6 Topics: Aged; Beta vulgaris; Biomarkers; Double-Blind Method; Exercise Therapy; Exercise Tolerance; Female;	2018
Beet the Best? Circulation research, 2018, 08-31, Volume: 123, Issue:6 Topics: Aged; Beta vulgaris; Biomarkers; Double-Blind Method; Exercise Therapy; Exercise Tolerance; Female;	2018
Dark chocolate acutely improves walking autonomy in patients with peripheral artery disease. Journal of the American Heart Association, 2014, Jul-02, Volume: 3, Issue:4 Topics: Aged; Antioxidants; Cacao; Candy; Catechin; Cross-Over Studies; Exercise Test; Exercise Tolerance; F	2014
A session of resistance exercise increases vasodilation in intermittent claudication patients. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2015, Volume: 40, Issue:1 Topics: Aged; Endothelium, Vascular; Female; Humans; Hyperemia; Hypertension; Intermittent Claudication; Leg	2015
Effects of chronic oral L-arginine administration on the L-arginine/NO pathway in patients with peripheral arterial occlusive disease or coronary artery disease: L-Arginine prevents renal loss of nitrite, the major NO reservoir. Amino acids, 2015, Volume: 47, Issue:9 Topics: Adult; Aged; Arginine; Double-Blind Method; Female; Humans; Kidney Tubules, Proximal; Male; Middle A	2015
Acute effects of walking and combined exercise on oxidative stress and vascular function in peripheral artery disease. Clinical physiology and functional imaging, 2018, Volume: 38, Issue:1 Topics: Aged; Ankle Brachial Index; Biomarkers; Blood Pressure; Female; Hemodynamics; Humans; Hyperemia; Int	2018
Long-term individual shear rate therapy counterpulsation enhances plasma nitrite release in patients with PAD. VASA. Zeitschrift fur Gefasskrankheiten, 2017, Volume: 46, Issue:1 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Counterpulsation; Cross-Over Studies; Exerci	2017
Plasma nitrite flux predicts exercise performance in peripheral arterial disease after 3months of exercise training. Free radical biology & medicine, 2010, Sep-15, Volume: 49, Issue:6 Topics: Athletic Performance; Brachial Artery; Electrocardiography; Endothelium, Vascular; Exercise Test; Ex	2010
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 110, Issue:6 Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood	2011

Article	Year
Human skeletal muscle nitrate and nitrite in individuals with peripheral arterial disease: Effect of inorganic nitrate supplementation and exercise. Physiological reports, 2022, Volume: 10, Issue:23 Topics: Dietary Supplements; Exercise; Humans; Muscle, Skeletal; Nitrates; Nitrites; Peripheral Arterial Dis	2022
Human skeletal muscle nitrate and nitrite in individuals with peripheral arterial disease: Effect of inorganic nitrate supplementation and exercise. Physiological reports, 2022, Volume: 10, Issue:23 Topics: Dietary Supplements; Exercise; Humans; Muscle, Skeletal; Nitrates; Nitrites; Peripheral Arterial Dis	2022
Human skeletal muscle nitrate and nitrite in individuals with peripheral arterial disease: Effect of inorganic nitrate supplementation and exercise. Physiological reports, 2022, Volume: 10, Issue:23 Topics: Dietary Supplements; Exercise; Humans; Muscle, Skeletal; Nitrates; Nitrites; Peripheral Arterial Dis	2022
Human skeletal muscle nitrate and nitrite in individuals with peripheral arterial disease: Effect of inorganic nitrate supplementation and exercise. Physiological reports, 2022, Volume: 10, Issue:23 Topics: Dietary Supplements; Exercise; Humans; Muscle, Skeletal; Nitrates; Nitrites; Peripheral Arterial Dis	2022
Alteration in the availability of epoxyeicosatrienoic acids contributes with NO to the development of endothelial dysfunction in conduit arteries during aging. Atherosclerosis, 2018, Volume: 275 Topics: Adult; Age Factors; Aged; Aging; Cytochrome P-450 Enzyme Inhibitors; Eicosanoids; Endothelium, Vascu	2018
Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome. American journal of physiology. Heart and circulatory physiology, 2015, Jul-01, Volume: 309, Issue:1 Topics: Angiogenesis Inducing Agents; Animals; Delayed-Action Preparations; Disease Models, Animal; Hindlimb	2015
[Peripheral arterial circulatory disorders and therapy. I. Rheoangiographic registration of the effect of nitroglycerin preparations in healthy subjects]. Zeitschrift fur Kreislaufforschung, 1956, Volume: 45, Issue:11-12 Topics: Healthy Volunteers; Nitrites; Nitroglycerin; Peripheral Arterial Disease; Peripheral Vascular Diseas	1956
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Intervention	change % dilation (Number)
BR Juice (Beet-It Stamina Shot) & Supervised Exercise Training	1.83
BR Juice Placebo and Exercise Training	-3.56

nitrites and Peripheral Arterial Diseases

Research Excerpts

Research

Studies (13)

Authors

Clinical Trials (10)

Trial Overview

Trial Outcomes

Change in Angiogenesis

Change In Claudication Onset Time

Change in Exercise Capacity: VO2peak (Maximal Oxygen Consumption)

Change in Functional Ability

Change In Time To Exhaustion

Change In Vascular Function (BAFMD)

Change in Angiogenesis

Change in Exercise Capacity - Claudication Onset Time (COT)

Change in Exercise Capacity - Maximal Oxygen Capacity (VO2peak)

Change in Exercise Capacity - Time to Exhaustion (TTE)

Change in Functional Ability

Change In Vascular Function

Trials

Other Studies