nitrites has been researched along with Multiple Sclerosis in 27 studies
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Multiple sclerosis is an unmet disease in which pathologies on the immune system, T-cells, and specific neural cells are involved simultaneously." | 1.38 | Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds. ( Alonso-Gil, S; Brea, J; Cadavid, MI; Campillo, NE; Gil, C; Loza, MI; Martin-Alvarez, R; Martinez, A; Mengod, G; Morales-García, JA; Paul-Fernandez, N; Perez, C; Perez, DI; Perez-Castillo, A; Redondo, M; Soteras, I; Val, C, 2012) |
| "Patients with DD, AIDS and RA had significantly elevated urinary nitrate plus nitrite (nit : creat." | 1.30 | Increased urinary nitric oxide metabolites in patients with multiple sclerosis correlates with early and relapsing disease. ( Elliot, M; Feldmann, M; Giovannoni, G; Heales, SJ; Land, JM; Miller, DH; Miller, RF; O'Riordan, J; Silver, NC; Thompson, EJ, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.41) | 18.7374 |
| 1990's | 10 (37.04) | 18.2507 |
| 2000's | 11 (40.74) | 29.6817 |
| 2010's | 4 (14.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haghikia, A | 2 |
| Kayacelebi, AA | 1 |
| Beckmann, B | 1 |
| Hanff, E | 1 |
| Gold, R | 1 |
| Tsikas, D | 1 |
| Levy, H | 1 |
| Assaf, Y | 1 |
| Frenkel, D | 1 |
| Virgili, N | 1 |
| Espinosa-Parrilla, JF | 1 |
| Mancera, P | 1 |
| Pastén-Zamorano, A | 1 |
| Gimeno-Bayon, J | 1 |
| Rodríguez, MJ | 1 |
| Mahy, N | 1 |
| Pugliese, M | 1 |
| Redondo, M | 1 |
| Brea, J | 1 |
| Perez, DI | 1 |
| Soteras, I | 1 |
| Val, C | 1 |
| Perez, C | 1 |
| Morales-García, JA | 1 |
| Alonso-Gil, S | 1 |
| Paul-Fernandez, N | 1 |
| Martin-Alvarez, R | 1 |
| Cadavid, MI | 1 |
| Loza, MI | 1 |
| Perez-Castillo, A | 1 |
| Mengod, G | 1 |
| Campillo, NE | 1 |
| Martinez, A | 1 |
| Gil, C | 1 |
| Nazliel, B | 1 |
| Taşkiran, D | 1 |
| Irkec, C | 1 |
| Kutay, FZ | 1 |
| Pöğün, S | 1 |
| Calabrese, V | 1 |
| Scapagnini, G | 1 |
| Ravagna, A | 1 |
| Bella, R | 1 |
| Foresti, R | 1 |
| Bates, TE | 1 |
| Giuffrida Stella, AM | 1 |
| Pennisi, G | 1 |
| Danilov, AI | 1 |
| Andersson, M | 2 |
| Bavand, N | 1 |
| Wiklund, NP | 2 |
| Olsson, T | 2 |
| Brundin, L | 2 |
| Acar, G | 1 |
| Idiman, F | 1 |
| Idiman, E | 1 |
| Kirkali, G | 1 |
| Cakmakçi, H | 1 |
| Ozakbaş, S | 1 |
| SOLTI, F | 1 |
| PETER, A | 1 |
| OLAH, I | 1 |
| SIMONYI, G | 1 |
| ISKUM, M | 1 |
| REV, J | 1 |
| HERMANN, R | 1 |
| Ramsaransing, GS | 1 |
| Teelken, A | 3 |
| Arutjunyan, AV | 2 |
| De Keyser, J | 3 |
| Rejdak, K | 1 |
| Eikelenboom, MJ | 1 |
| Petzold, A | 1 |
| Thompson, EJ | 4 |
| Stelmasiak, Z | 1 |
| Lazeron, RH | 1 |
| Barkhof, F | 1 |
| Polman, CH | 1 |
| Uitdehaag, BM | 1 |
| Giovannoni, G | 4 |
| Bizzozero, OA | 1 |
| DeJesus, G | 1 |
| Bixler, HA | 1 |
| Pastuszyn, A | 1 |
| Koch, M | 1 |
| Mostert, J | 1 |
| Arutjunyan, A | 1 |
| Stepanov, M | 1 |
| Heersema, D | 1 |
| Johnson, AW | 1 |
| Land, JM | 3 |
| Bolaños, JP | 1 |
| Clark, JB | 2 |
| Heales, SJ | 3 |
| Ikeda, M | 1 |
| Sato, I | 1 |
| Matsunaga, T | 1 |
| Takahashi, M | 1 |
| Yuasa, T | 1 |
| Murota, S | 1 |
| Silver, NC | 2 |
| O'Riordan, J | 2 |
| Miller, RF | 2 |
| Sarchielli, P | 1 |
| Orlacchio, A | 1 |
| Vicinanza, F | 1 |
| Pelliccioli, GP | 1 |
| Tognoloni, M | 1 |
| Saccardi, C | 1 |
| Gallai, V | 1 |
| Cross, AH | 1 |
| Manning, PT | 1 |
| Keeling, RM | 1 |
| Schmidt, RE | 1 |
| Misko, TP | 1 |
| Morcos, E | 1 |
| Elliot, M | 1 |
| Feldmann, M | 1 |
| Miller, DH | 1 |
| Svenningsson, A | 1 |
| Petersson, AS | 1 |
| Andersen, O | 1 |
| Hansson, GK | 1 |
| Molina-Holgado, F | 1 |
| Hernanz, A | 1 |
| De la Fuente, M | 1 |
| Guaza, C | 1 |
| Drulović, J | 2 |
| Dujmović, I | 2 |
| Mesaros, S | 2 |
| Samardzić, T | 2 |
| Maksimović, D | 2 |
| Stojsavljević, N | 2 |
| Lević, Z | 2 |
| Mostarica Stojokvić, M | 1 |
| Beenakker, EA | 1 |
| Oparina, TI | 1 |
| Hartgring, A | 1 |
| Miljkovic, Dj | 1 |
| Trajkovic, V | 1 |
| Mostarica Stojkovic, M | 1 |
| Irvine, DG | 1 |
| Schiefer, HB | 1 |
| Hader, WJ | 1 |
5 trials available for nitrites and Multiple Sclerosis
| Article | Year |
|---|---|
Serum and cerebrospinal fluid concentrations of homoarginine, arginine, asymmetric and symmetric dimethylarginine, nitrite and nitrate in patients with multiple sclerosis and neuromyelitis optica.
Topics: Adult; Arginine; Female; Homoarginine; Humans; Male; Middle Aged; Multiple Sclerosis; Neuromyelitis | 2015 |
Serum nitric oxide metabolites in patients with multiple sclerosis.
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Nitrate Reductase; Nitrate Reduc | 2002 |
Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels.
Topics: Adult; Blotting, Western; Catalase; Cerebrospinal Fluid Proteins; Female; Glutathione; Glutathione D | 2002 |
Increased intrathecal nitric oxide formation in multiple sclerosis; cerebrospinal fluid nitrite as activity marker.
Topics: Adult; Aged; Biomarkers; Disease Progression; Electrophoresis, Capillary; Female; Humans; Male; Midd | 1999 |
Cooling garment treatment in MS: clinical improvement and decrease in leukocyte NO production.
Topics: Adult; Body Temperature; Cross-Over Studies; Cryotherapy; Female; Humans; Leukocytes; Male; Middle A | 2001 |
22 other studies available for nitrites and Multiple Sclerosis
| Article | Year |
|---|---|
Characterization of brain lesions in a mouse model of progressive multiple sclerosis.
Topics: Animals; Astrocytes; Blotting, Western; Brain; Coculture Techniques; Contrast Media; Diffusion Magne | 2010 |
Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Cell Line; Diazoxi | 2011 |
Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood-Brain Barrier; Cell Survival; Cyclic AMP; Cy | 2012 |
Nitric oxide metabolite determinations reveal continuous inflammation in multiple sclerosis.
Topics: Adult; Biomarkers; Central Nervous System; Female; Humans; Inflammation; Male; Middle Aged; Multiple | 2003 |
Nitric oxide as an activity marker in multiple sclerosis.
Topics: Adolescent; Adult; Biomarkers; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multip | 2003 |
[ON THE EFFECT OF SODIUM NITRITE ON CEREBRAL CIRCULATION, PRESSURE OF THE CENTRAL RETINAL ARTERY AND CEREBROSPINAL FLUID PRESSURE].
Topics: Cerebrospinal Fluid; Cerebrospinal Fluid Pressure; Cerebrovascular Circulation; Humans; Hypertension | 1963 |
Peripheral blood leukocyte NO production in MS patients with a benign vs progressive course.
Topics: Adult; Axons; Female; Humans; Interleukin-12; Leukocytes; Male; Middle Aged; Multiple Sclerosis; Mul | 2004 |
CSF nitric oxide metabolites are associated with activity and progression of multiple sclerosis.
Topics: Adult; Aged; Biomarkers; Central Nervous System; Cross-Sectional Studies; Disability Evaluation; Dis | 2004 |
Evidence of nitrosative damage in the brain white matter of patients with multiple sclerosis.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Brain; Female; Humans; Male; Middle Aged; Mult | 2005 |
Peripheral blood leukocyte NO production and oxidative stress in multiple sclerosis.
Topics: Adult; Biphenyl Compounds; Female; Humans; Hydrogen Peroxide; Indicators and Reagents; Leukocytes; M | 2008 |
Evidence for increased nitric oxide production in multiple sclerosis.
Topics: Brain; Humans; Mass Spectrometry; Multiple Sclerosis; Nitrates; Nitric Oxide; Nitrites | 1995 |
Cyclic guanosine monophosphate (cGMP), nitrite and nitrate in the cerebrospinal fluid in meningitis, multiple sclerosis and Guillain-Barré syndrome.
Topics: Adult; Biomarkers; Brain; Cyclic GMP; Humans; Meningitis; Middle Aged; Multiple Sclerosis; Nitrates; | 1995 |
Raised serum nitrate and nitrite levels in patients with multiple sclerosis.
Topics: Acquired Immunodeficiency Syndrome; Adult; Female; HIV-1; Humans; Male; Middle Aged; Multiple Sclero | 1997 |
Cytokine secretion and nitric oxide production by mononuclear cells of patients with multiple sclerosis.
Topics: Adult; Cytokines; Female; Humans; Leukocytes, Mononuclear; Lipopolysaccharides; Lymphocytes; Male; M | 1997 |
Cerebrospinal fluid and serum nitric oxide metabolites in patients with multiple sclerosis.
Topics: Adult; Albumins; Blood-Brain Barrier; Female; Humans; Linear Models; Male; Middle Aged; Multiple Scl | 1998 |
Peroxynitrite formation within the central nervous system in active multiple sclerosis.
Topics: Central Nervous System; Humans; Immunohistochemistry; Inflammation; Multiple Sclerosis; Nervous Syst | 1998 |
Increased urinary nitric oxide metabolites in patients with multiple sclerosis correlates with early and relapsing disease.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Arthritis, Rheumatoid; CD4 Lymphocyte Count; Creati | 1999 |
Nitric oxide metabolites in CSF of patients with MS are related to clinical disease course.
Topics: Humans; Lymphocytes; Meningitis; Multiple Sclerosis; Nitrates; Nitric Oxide; Nitrites; Reference Val | 1999 |
N-Acetyl-cysteine inhibition of encephalomyelitis Theiler's virus-induced nitric oxide and tumour necrosis factor-alpha production by murine astrocyte cultures.
Topics: Acetylcysteine; Animals; Animals, Newborn; Astrocytes; Cardiovirus Infections; Cells, Cultured; Cere | 1999 |
Raised cerebrospinal fluid nitrite and nitrate levels in patients with multiple sclerosis: no correlation with disease activity.
Topics: Adolescent; Adult; Aged; Autoimmune Diseases; Brain Neoplasms; Female; Humans; Magnetic Resonance Im | 2001 |
Nitric oxide metabolites and interleukin-6 in cerebrospinal fluid from multiple sclerosis patients.
Topics: Adult; Female; Humans; Interleukin-6; Male; Middle Aged; Multiple Sclerosis; Nitrates; Nitric Oxide; | 2002 |
Geotoxicology of multiple sclerosis: the Henribourg, Saskatchewan, cluster focus. II. The soil.
Topics: Canada; Geography; Humans; Metals; Multiple Sclerosis; Nitrates; Nitrites; Risk Factors; Saskatchewa | 1988 |