nitrites has been researched along with Multiple Organ Failure in 40 studies
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
Multiple Organ Failure: A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We evaluated the role of melatonin in endotoxemia caused by lipopolysaccharide (LPS) in unanesthetized rats." | 7.70 | Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats. ( Acuña-Castroviejo, D; Crespo, E; Escames, G; Guerrero, JM; Macías, M; Martín, M; Pozo, D; Vives, F, 1999) |
| " To evaluate the effects of NO radical on the liver in patients with postoperative sepsis, we analysed both the stable end-product of nitric oxide radical (NOx) as well as the arterial KBR (AKBR), which reflects liver tissue NAD+/NADH." | 5.09 | Nitric oxide production and hepatic dysfunction in patients with postoperative sepsis. ( Inoue, T; Kamiyama, Y; Kitade, H; Kwon, AH; Satoi, S; Takahashi, H; Takahashi, K; Wei, T, 2000) |
| "Peritonitis sepsis induced multiple organ dysfunction, mitochondrial abnormalities, and increased mortality rate, which were reduced by pharmacological inhibition of mitochondrial transition by cyclosporine derivatives and mitochondrial Bcl-2 overexpression." | 3.73 | Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality. ( Chopin, C; Decoster, B; Favory, R; Hassoun, SM; Lancel, S; Larche, J; Marchetti, P; Neviere, R, 2006) |
| "Fifty-one consecutive children with sepsis and six critically ill children without sepsis were enrolled and given 18 mg/kg antipyrine per NG." | 3.72 | Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure. ( Burckart, GJ; Carcillo, JA; Doughty, L; Frye, RF; Kaplan, SS; Kofos, D; Sasser, H, 2003) |
| "We evaluated the role of melatonin in endotoxemia caused by lipopolysaccharide (LPS) in unanesthetized rats." | 3.70 | Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats. ( Acuña-Castroviejo, D; Crespo, E; Escames, G; Guerrero, JM; Macías, M; Martín, M; Pozo, D; Vives, F, 1999) |
| "Increased plasma nitrite/nitrates and increased organ failure scores occurred in the children with sepsis who had an exaggerated proinflammatory state, despite a pronounced anti-inflammatory response." | 3.69 | Inflammatory cytokine and nitric oxide responses in pediatric sepsis and organ failure. ( Carcillo, JA; Doughty, LA; Kaplan, SS, 1996) |
| " In addition, all tyrphostins and genistein attenuated the liver injury/failure, the pancreatic injury, the hypoglycaemia and the lactic acidosis caused by LPS." | 3.69 | Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase. ( Ruetten, H; Thiemermann, C, 1997) |
| "Death from septic shock is caused by refractory hypotension and multiple organ failure (MOF)." | 2.47 | Nitrite regulation of shock. ( Brouckaert, P; Cauwels, A, 2011) |
| "Mortality of patients with acute liver failure (ALF) is still unacceptably high." | 1.39 | Evaluation of the Hepa Wash® treatment in pigs with acute liver failure. ( Al-Chalabi, A; Huber, W; Kreymann, B; Luppa, P; Matevossian, E; Nairz, E; Neiss, A; Perren, A; Radermacher, P; Schimmel, P; Schmid, RM; Schreiber, C; Schuster, T; V Thaden, AK; Yang, Z, 2013) |
| "Treatment with olprinone attenuated the peritoneal exudation and the migration of polymorphonuclear cells caused by zymosan." | 1.37 | Olprinone, a specific phosphodiesterase (PDE)-III inhibitor, reduces the development of multiple organ dysfunction syndrome in mice. ( Bramanti, P; Cuzzocrea, S; Di Paola, R; Esposito, E; Impellizzeri, D; Mazzon, E, 2011) |
| "MODS was induced by zymosan administration (500 mg/kg, suspended in saline solution, i." | 1.35 | Absence of endogenous interleukin-10 enhanced organ dysfunction and mortality associated to zymosan-induced multiple organ dysfunction syndrome. ( Bramanti, P; Caminiti, R; Cuzzocrea, S; Di Paola, R; Esposito, E; Genovese, T; Malleo, G; Mazzon, E, 2008) |
| "Melatonin treatment counteracted these alterations in young and aged septic rats." | 1.33 | Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: effects of melatonin treatment. ( Acuña-Castroviejo, D; Escames, G; López, LC; Ortiz, F; Ros, E, 2006) |
| "Infection is a microbial phenomenon characterized by an inflammatory response to the presence of microorganism." | 1.32 | Relationships of circulating nitrite/nitrate levels to severity and multiple organ dysfunction syndrome in systemic inflammatory response syndrome. ( Hirata, Y; Hirokawa, M; Imai, T; Mitaka, C; Nosaka, T; Wakimoto, H; Yokoyama, K, 2003) |
| "Gram-positive septic shock was induced by coadministration of LTA (3 mg/kg i." | 1.31 | Membrane-permeable radical scavenger, tempol, reduces multiple organ injury in a rodent model of gram-positive shock. ( Cuzzocrea, S; Foster, SJ; Olbrich, A; Thiemermann, C; Zacharowski, K, 2000) |
| "To produce a rat model of brain death, we inflated a subdurally placed balloon catheter." | 1.31 | No evidence of NO-induced damage in potential donor organs after brain death. ( Fukuyama, N; Halejcio-Delophont, P; Hoshiai, K; Nakazawa, H, 2001) |
| "The incidence of sepsis and septic shock due to gram-positive organisms has increased dramatically over the last two decades." | 1.31 | A cell wall component from pathogenic and non-pathogenic gram-positive bacteria (peptidoglycan) synergises with endotoxin to cause the release of tumour necrosis factor-alpha, nitric oxide production, shock, and multiple organ injury/dysfunction in the ra ( Foster, SJ; Hinds, CJ; Thiemermann, C; Wray, GM, 2001) |
| "To determine in children with sepsis syndrome and septic shock the time course of nitric oxide metabolites: nitrate and nitrite (nitrogen oxides)." | 1.30 | Activation of the L-arginine nitric oxide pathway in severe sepsis. ( Duke, T; South, M; Stewart, A, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (42.50) | 18.2507 |
| 2000's | 16 (40.00) | 29.6817 |
| 2010's | 7 (17.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Al-Chalabi, A | 1 |
| Matevossian, E | 1 |
| V Thaden, AK | 1 |
| Luppa, P | 1 |
| Neiss, A | 1 |
| Schuster, T | 1 |
| Yang, Z | 1 |
| Schreiber, C | 1 |
| Schimmel, P | 1 |
| Nairz, E | 1 |
| Perren, A | 1 |
| Radermacher, P | 1 |
| Huber, W | 1 |
| Schmid, RM | 1 |
| Kreymann, B | 1 |
| Shen, HH | 1 |
| Lam, KK | 1 |
| Cheng, PY | 1 |
| Kung, CW | 1 |
| Chen, SY | 1 |
| Lin, PC | 1 |
| Chung, MT | 1 |
| Lee, YM | 1 |
| Guerreiro, MO | 1 |
| Petronilho, F | 1 |
| Andrades, M | 1 |
| Constantino, L | 1 |
| Mina, FG | 1 |
| Moreira, JC | 1 |
| Dal-Pizzol, F | 1 |
| Ritter, C | 1 |
| Cauwels, A | 1 |
| Brouckaert, P | 1 |
| Mazzon, E | 6 |
| Esposito, E | 3 |
| Di Paola, R | 4 |
| Impellizzeri, D | 2 |
| Bramanti, P | 3 |
| Cuzzocrea, S | 7 |
| Paterniti, I | 1 |
| Galuppo, M | 1 |
| Nocentini, G | 1 |
| Ronchetti, S | 1 |
| Riccardi, L | 1 |
| Bruscoli, S | 1 |
| Riccardi, C | 1 |
| Mitaka, C | 1 |
| Hirata, Y | 1 |
| Yokoyama, K | 1 |
| Wakimoto, H | 1 |
| Hirokawa, M | 1 |
| Nosaka, T | 1 |
| Imai, T | 1 |
| Carcillo, JA | 5 |
| Doughty, L | 4 |
| Kofos, D | 1 |
| Frye, RF | 1 |
| Kaplan, SS | 3 |
| Sasser, H | 2 |
| Burckart, GJ | 1 |
| Hsu, DZ | 1 |
| Li, YH | 1 |
| Chu, PY | 1 |
| Chien, SP | 1 |
| Chuang, YC | 1 |
| Liu, MY | 1 |
| Larche, J | 1 |
| Lancel, S | 1 |
| Hassoun, SM | 1 |
| Favory, R | 1 |
| Decoster, B | 1 |
| Marchetti, P | 1 |
| Chopin, C | 1 |
| Neviere, R | 1 |
| Maybauer, DM | 1 |
| Maybauer, MO | 1 |
| Traber, LD | 1 |
| Westphal, M | 1 |
| Nakano, YY | 1 |
| Enkhbaatar, P | 1 |
| Morita, N | 1 |
| Herndon, DN | 1 |
| Traber, DL | 1 |
| Escames, G | 2 |
| López, LC | 1 |
| Ortiz, F | 1 |
| Ros, E | 1 |
| Acuña-Castroviejo, D | 2 |
| Kikuchi, M | 1 |
| Endo, S | 4 |
| Inada, K | 4 |
| Inoue, Y | 2 |
| Wakabayashi, G | 3 |
| Ishikura, H | 1 |
| Tanaka, T | 1 |
| Malleo, G | 1 |
| Genovese, T | 1 |
| Caminiti, R | 1 |
| Hwang, WS | 1 |
| Chen, SH | 1 |
| Lin, CH | 1 |
| Chang, HK | 1 |
| Chen, WC | 1 |
| Lin, MT | 1 |
| Doughty, LA | 1 |
| Ruetten, H | 2 |
| Southan, GJ | 1 |
| Abate, A | 1 |
| Thiemermann, C | 7 |
| Takakuwa, T | 2 |
| Kasai, T | 2 |
| Yamada, Y | 3 |
| Niimi, M | 2 |
| Suzuki, T | 1 |
| Taniguchi, S | 2 |
| Duke, T | 1 |
| South, M | 1 |
| Stewart, A | 1 |
| Kan, H | 1 |
| Finkel, MS | 1 |
| Kaplan, S | 2 |
| Janosky, J | 2 |
| Wray, GM | 4 |
| Millar, CG | 1 |
| Hinds, CJ | 3 |
| Koike, S | 1 |
| Endo, Y | 1 |
| Leach, M | 1 |
| Hamilton, LC | 1 |
| Olbrich, A | 2 |
| Wang, Y | 1 |
| Lawson, JA | 1 |
| Jaeschke, H | 1 |
| Kamei, Y | 1 |
| Minato, T | 1 |
| Yokoyama, M | 2 |
| Nakae, H | 1 |
| Ogawa, M | 1 |
| de Sarro, G | 1 |
| Costantino, G | 1 |
| Laurà, R | 1 |
| Ciriaco, E | 1 |
| de Sarro, A | 1 |
| Caputi, AP | 2 |
| Crespo, E | 1 |
| Macías, M | 1 |
| Pozo, D | 1 |
| Martín, M | 1 |
| Vives, F | 1 |
| Guerrero, JM | 1 |
| Yamashita, T | 1 |
| Kawashima, S | 1 |
| Ohashi, Y | 1 |
| Ozaki, M | 1 |
| Ueyama, T | 1 |
| Ishida, T | 1 |
| Inoue, N | 1 |
| Hirata, K | 1 |
| Akita, H | 1 |
| Satoi, S | 1 |
| Kamiyama, Y | 1 |
| Kitade, H | 1 |
| Kwon, AH | 1 |
| Takahashi, K | 1 |
| Wei, T | 1 |
| Inoue, T | 1 |
| Takahashi, H | 1 |
| Zacharowski, K | 1 |
| Foster, SJ | 2 |
| Tanjoh, K | 1 |
| Tomita, R | 1 |
| Hayashi, N | 1 |
| Halejcio-Delophont, P | 1 |
| Hoshiai, K | 1 |
| Fukuyama, N | 1 |
| Nakazawa, H | 1 |
| Dugo, L | 1 |
| Barbera, A | 1 |
| Centorrino, T | 1 |
| Ciccolo, A | 1 |
| Fonti, MT | 1 |
| Green, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Critical Illness Stress-induced Immune Suppression Prevention Trial[NCT00395161] | Phase 3 | 293 participants (Actual) | Interventional | 2007-04-30 | Terminated (stopped due to Terminated for futility on 11/30/09 based on the recommendation of the DSMB) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00395161)
Timeframe: 28 days after admission to the PICU
| Intervention | participants (Number) |
|---|---|
| Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide | 15 |
| Enteral Whey Protein, IV Saline | 8 |
(NCT00395161)
Timeframe: 48 hours after admission until PICU discharge
| Intervention | Days (Median) |
|---|---|
| Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide | 1 |
| Enteral Whey Protein, IV Saline | 2 |
What is reported is the number of participants with counts qualifying as lymphopenia. (NCT00395161)
Timeframe: from time of PICU admission till discharge from PICU
| Intervention | participants (Number) |
|---|---|
| Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide | 5 |
| Enteral Whey Protein, IV Saline | 12 |
(NCT00395161)
Timeframe: 48 hours after PICU admission till discharge from PICU
| Intervention | Mean number of events per 100 study days (Mean) |
|---|---|
| Daily Nutriceutical Supplementation | 4.99 |
| Whey Protein | 4.83 |
(NCT00395161)
Timeframe: 48 hours after admission until 5 days after discharged from the PICU
| Intervention | Days (Median) |
|---|---|
| Daily Nutriceutical Supplementation | 12.1 |
| Whey Protein | 13.2 |
1 review available for nitrites and Multiple Organ Failure
| Article | Year |
|---|---|
Nitrite regulation of shock.
Topics: Animals; Humans; Mitochondria; Multiple Organ Failure; Nitric Oxide; Nitrites; Shock, Septic; Tumor | 2011 |
2 trials available for nitrites and Multiple Organ Failure
| Article | Year |
|---|---|
Nuclear matrix protein, tumor necrosis factor-alpha, and nitrite/nitrate levels in patients with multiple organ dysfunction syndrome.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antigens, Nuclear; Apoptosis; Biomarkers; Enzyme-Linked | 1998 |
Nitric oxide production and hepatic dysfunction in patients with postoperative sepsis.
Topics: Aged; Female; Humans; Ketone Bodies; Liver Diseases; Male; Mitochondria, Liver; Multiple Organ Failu | 2000 |
37 other studies available for nitrites and Multiple Organ Failure
| Article | Year |
|---|---|
Evaluation of the Hepa Wash® treatment in pigs with acute liver failure.
Topics: Ammonia; Animals; Blood Pressure; Cardiac Output; Creatinine; Dialysis; Disease Models, Animal; Fema | 2013 |
Alpha-lipoic acid prevents endotoxic shock and multiple organ dysfunction syndrome induced by endotoxemia in rats.
Topics: Animals; Antioxidants; Antithrombins; Aorta; Caspase 3; Disulfides; Endotoxemia; Enzyme Activation; | 2015 |
Plasma superoxide dismutase activity and mortality in septic patients [corrected].
Topics: APACHE; Biomarkers; Catalase; Chi-Square Distribution; Female; Humans; Male; Middle Aged; Multiple O | 2010 |
Olprinone, a specific phosphodiesterase (PDE)-III inhibitor, reduces the development of multiple organ dysfunction syndrome in mice.
Topics: Alanine Transaminase; Alkaline Phosphatase; Amylases; Animals; Apoptosis; Ascitic Fluid; Aspartate A | 2011 |
Effect of NADPH-oxidase inhibitors in the experimental model of zymosan-induced shock in mice.
Topics: Acetophenones; Animals; Apoptosis; Cytokines; Enzyme Inhibitors; Male; Mice; Multiple Organ Failure; | 2011 |
GITR gene deletion and GITR-FC soluble protein administration inhibit multiple organ failure induced by zymosan.
Topics: Animals; Cell Adhesion Molecules; Gene Deletion; Glucocorticoid-Induced TNFR-Related Protein; Immuno | 2011 |
Relationships of circulating nitrite/nitrate levels to severity and multiple organ dysfunction syndrome in systemic inflammatory response syndrome.
Topics: Aged; Aged, 80 and over; APACHE; Female; Humans; Infections; Male; Middle Aged; Multiple Organ Failu | 2003 |
Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure.
Topics: Adolescent; Age Factors; Analysis of Variance; Antipyrine; Case-Control Studies; Child; Child, Presc | 2003 |
Attenuation of endotoxin-induced oxidative stress and multiple organ injury by 3,4-Methylenedioxyphenol in rats.
Topics: Animals; Antioxidants; Benzodioxoles; Disease Models, Animal; Endotoxins; Kidney; Lipopolysaccharide | 2006 |
Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality.
Topics: Animals; Bronchoalveolar Lavage Fluid; Caspases; Cyclosporine; Disease Models, Animal; Immunosuppres | 2006 |
Effects of severe smoke inhalation injury and septic shock on global hemodynamics and microvascular blood flow in sheep.
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Heart Rate; Lung; Microcirculation; Multipl | 2006 |
Age-dependent lipopolysaccharide-induced iNOS expression and multiorgan failure in rats: effects of melatonin treatment.
Topics: Aging; Animals; Antioxidants; Endotoxemia; Enzyme Induction; Injections; Kidney Diseases; Lipid Pero | 2006 |
Assessment of inflammatory mediators in patients with generalized peritonitis.
Topics: Adult; Aged; Aged, 80 and over; Cytokines; Endotoxins; Female; Group IV Phospholipases A2; Humans; I | 1999 |
Absence of endogenous interleukin-10 enhanced organ dysfunction and mortality associated to zymosan-induced multiple organ dysfunction syndrome.
Topics: Animals; Gene Deletion; Interleukin-10; Interleukin-1beta; Kidney; Lipid Peroxidation; Liver; Mice; | 2008 |
Human umbilical cord blood-derived CD34+ cells can be used as a prophylactic agent for experimental heatstroke.
Topics: Animals; Antigens, CD34; Basal Ganglia; Cerebrovascular Disorders; Cord Blood Stem Cell Transplantat | 2008 |
Inflammatory cytokine and nitric oxide responses in pediatric sepsis and organ failure.
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Interleukin-10; Interl | 1996 |
Attenuation of endotoxin-induced multiple organ dysfunction by 1-amino-2-hydroxy-guanidine, a potent inhibitor of inducible nitric oxide synthase.
Topics: Animals; Cell Line; Enzyme Inhibitors; Guanidines; Kidney; Lipopolysaccharides; Liver; Lung; Macroph | 1996 |
Nitrite/nitrate (NOx) and sFas antigen levels in patients with multiple organ failure.
Topics: fas Receptor; Humans; Multiple Organ Failure; Nitrates; Nitrites; Sepsis | 1996 |
Activation of the L-arginine nitric oxide pathway in severe sepsis.
Topics: Adolescent; Arginine; Biomarkers; Child; Child, Preschool; Female; Humans; Infant; Male; Multiple Or | 1997 |
Effects of tyrphostins and genistein on the circulatory failure and organ dysfunction caused by endotoxin in the rat: a possible role for protein tyrosine kinase.
Topics: Acidosis, Lactic; Animals; Cells, Cultured; Cyclooxygenase 2; Endotoxemia; Endotoxins; Enzyme Induct | 1997 |
Is the answer NO?
Topics: Animals; Bacteremia; Child; Humans; Multiple Organ Failure; Nitrates; Nitrites; Rabbits | 1998 |
Plasma nitrite and nitrate concentrations and multiple organ failure in pediatric sepsis.
Topics: Adolescent; Bacteremia; Child; Child, Preschool; Follow-Up Studies; Humans; Infant; Infant, Newborn; | 1998 |
Selective inhibition of the activity of inducible nitric oxide synthase prevents the circulatory failure, but not the organ injury/dysfunction, caused by endotoxin.
Topics: Amidines; Animals; Benzylamines; Enzyme Inhibitors; Escherichia coli; Hemodynamics; Kidney; Lipopoly | 1998 |
The compensatory anti-inflammatory cytokine interleukin 10 response in pediatric sepsis-induced multiple organ failure.
Topics: Adolescent; Blood Cells; Cells, Cultured; Child; Child, Preschool; Humans; Infant; Infant, Newborn; | 1998 |
Effects of inhibitors of the activity of cyclo-oxygenase-2 on the hypotension and multiple organ dysfunction caused by endotoxin: a comparison with dexamethasone.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyc | 1998 |
Effects of inhibitors of poly(ADP-ribose) synthetase activity on hypotension and multiple organ dysfunction caused by endotoxin.
Topics: Animals; Benzamides; Endotoxemia; Enzyme Inhibitors; Hemodynamics; Hypotension; Isoquinolines; Kidne | 1998 |
Differential effect of 2-aminoethyl-isothiourea, an inhibitor of the inducible nitric oxide synthase, on microvascular blood flow and organ injury in models of hepatic ischemia-reperfusion and endotoxemia.
Topics: Alanine Transaminase; Animals; beta-Aminoethyl Isothiourea; Blood Circulation; Blood Pressure; Endot | 1998 |
Plasma levels of type II phospholipase A2 and nitrite/nitrate in patients with burns.
Topics: Adult; Aged; Biomarkers; Burns; Enzyme-Linked Immunosorbent Assay; Female; Group II Phospholipases A | 1998 |
Role of interleukin-6 in a non-septic shock model induced by zymosan.
Topics: Animals; Antibodies, Monoclonal; Ascites; Ascitic Fluid; DNA Damage; Energy Metabolism; Injections, | 1999 |
Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide-induced multiple organ dysfunction syndrome in rats.
Topics: Animals; Drug Administration Schedule; Endotoxemia; Gene Expression Regulation, Enzymologic; Kidney; | 1999 |
Resistance to endotoxin shock in transgenic mice overexpressing endothelial nitric oxide synthase.
Topics: Animals; Aorta; Blood Pressure; Cyclic GMP; Edema; Female; Granulocytes; Hypotension; Immunity, Inna | 2000 |
Membrane-permeable radical scavenger, tempol, reduces multiple organ injury in a rodent model of gram-positive shock.
Topics: Animals; Blood Pressure; Cyclic N-Oxides; Free Radical Scavengers; Kidney; Lipopolysaccharides; Live | 2000 |
Antisense oligodeoxynucleotides to human inducible nitric oxide synthase selectively inhibit induced nitric oxide production by human vascular endothelial cells: an experimental study.
Topics: Cells, Cultured; Data Interpretation, Statistical; DNA Primers; DNA, Complementary; Endothelium, Vas | 2000 |
No evidence of NO-induced damage in potential donor organs after brain death.
Topics: Animals; Biomarkers; Brain Death; Chromatography, High Pressure Liquid; Heart Transplantation; Hemod | 2001 |
A cell wall component from pathogenic and non-pathogenic gram-positive bacteria (peptidoglycan) synergises with endotoxin to cause the release of tumour necrosis factor-alpha, nitric oxide production, shock, and multiple organ injury/dysfunction in the ra
Topics: Animals; Bacillus subtilis; Blood Pressure; Cell Wall; Dose-Response Relationship, Drug; Drug Synerg | 2001 |
Inducible nitric oxide synthase knockout mice exhibit resistance to the multiple organ failure induced by zymosan.
Topics: Animals; Enzyme Inhibitors; Exudates and Transudates; Guanidines; Lipid Peroxidation; Liver; Lung; M | 2001 |
The tissue factor and plasminogen activator inhibitor type-1 response in pediatric sepsis-induced multiple organ failure.
Topics: Adolescent; Child; Child, Preschool; Cytokines; Endothelium, Vascular; Female; Fibrinolysis; Humans; | 2002 |