nitrites has been researched along with Intermittent Claudication in 8 studies
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
Intermittent Claudication: A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.
Excerpt | Relevance | Reference |
---|---|---|
" The aim of this study was to analyse the effects of a single session of resistance exercise on blood flow, reactive hyperemia, plasma nitrite, and plasma malondialdehyde in patients with peripheral artery disease." | 5.20 | A session of resistance exercise increases vasodilation in intermittent claudication patients. ( Brasileiro-Santos, M; Correia, M; Forjaz, CL; Lima, A; Miranda, A; Ritti-Dias, R; Santos, A; Silva, A; Sobral Filho, D, 2015) |
" Nitric oxide (NO) bioavailability is essential for vascular health and function." | 2.76 | Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. ( Allen, JD; Ham, KL; Johnson, JL; Kenjale, AA; Kraus, WE; Privette, G; Robbins, JL; Stabler, T; Vanbruggen, M; Yim, E, 2011) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (12.50) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (12.50) | 29.6817 |
2010's | 6 (75.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Woessner, M | 1 |
VanBruggen, MD | 1 |
Pieper, CF | 1 |
Sloane, R | 1 |
Kraus, WE | 2 |
Gow, AJ | 1 |
Allen, JD | 3 |
Lima, A | 1 |
Ritti-Dias, R | 1 |
Forjaz, CL | 1 |
Correia, M | 1 |
Miranda, A | 1 |
Brasileiro-Santos, M | 1 |
Santos, A | 1 |
Sobral Filho, D | 1 |
Silva, A | 1 |
Lima, AHRA | 1 |
Correia, MA | 1 |
Soares, AHG | 1 |
Farah, BQ | 1 |
Forjaz, CLM | 1 |
Silva, AS | 1 |
Brasileiro-Santos, MS | 1 |
Santos, AC | 1 |
Ritti-Dias, RM | 1 |
Brix, M | 1 |
Buschmann, EE | 1 |
Zietzer, A | 1 |
Jaurigue, JA | 1 |
Li, L | 1 |
Jungk, C | 1 |
Buschmann, I | 1 |
Janke, D | 1 |
Hillmeister, P | 1 |
Sutkowska, E | 1 |
Wozniewski, M | 1 |
Gamian, A | 1 |
Gosk-Bierska, I | 1 |
Alexewicz, P | 1 |
Sutkowski, K | 1 |
Wysokinski, WE | 1 |
Stabler, T | 2 |
Kenjale, A | 1 |
Ham, KL | 2 |
Robbins, JL | 2 |
Duscha, BD | 1 |
Dobrosielski, DA | 1 |
Annex, BH | 1 |
Kenjale, AA | 1 |
Johnson, JL | 1 |
Vanbruggen, M | 1 |
Privette, G | 1 |
Yim, E | 1 |
POLETTI, RA | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Increased Plasma Nitrite, Tissue Oxygenation and Functional Changes in PAD[NCT01684930] | Phase 2 | 32 participants (Actual) | Interventional | 2012-06-30 | Completed | ||
Dietary Nitrate to Augment Exercise Training Benefits in Subjects With Type II Diabetes (DM) and Peripheral Arterial Disease (PAD)[NCT01785524] | Phase 2 | 18 participants (Actual) | Interventional | 2013-02-28 | Completed | ||
Dietary Nitrates for Heart Failure[NCT01682356] | Phase 1/Phase 2 | 126 participants (Anticipated) | Interventional | 2012-01-31 | Active, not recruiting | ||
Nitrite Supplementation to Mitigate Fatigability and Increase Function in Long COVID Patients[NCT05618574] | Phase 3 | 40 participants (Anticipated) | Interventional | 2023-12-01 | Recruiting | ||
Acute Effects of Beet Juice Consumption on Exercise Capacity in Heart Failure[NCT01946542] | Phase 1/Phase 2 | 2 participants (Actual) | Interventional | 2014-02-28 | Terminated (stopped due to Low enrollment) | ||
Dietary Nitrate Supplementation and Thermoregulation During Exercise[NCT03506646] | 10 participants (Anticipated) | Interventional | 2018-09-05 | Active, not recruiting | |||
Strength Testing After Nitrate Delivery (STAND) in ICU Patients[NCT02293616] | 25 participants (Actual) | Interventional | 2015-06-30 | Completed | |||
The Effects of Oral Inorganic Nitrate Supplementation on Lower Limb Perfusion and Metabolism During Exercise in Patients With Peripheral Arterial Disease (PAD)[NCT05036213] | Phase 1 | 28 participants (Anticipated) | Interventional | 2020-02-01 | Recruiting | ||
Acute Dietary Nitrate Supplementation to Improve Performance in Endurance Trained Athletes[NCT01384968] | 20 participants (Actual) | Interventional | 2011-07-31 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Gastrocnemious muscle biopsy will be performed to measure the number of capillaries per fibre as a marker of change in angiogenesis between groups (NCT01684930)
Timeframe: Baseline and 16 weeks
Intervention | capillaries per fibrer (Mean) |
---|---|
BR Juice (Beet-It Stamina Shot) and Exercise Training | 0.38 |
BR Juice Placebo and Exercise Training | 0.26 |
Exercise capacity will be assessed using a maximal cardiopulmonary exercise (CPX) test with expired gas analysis, for determination of claudication onset time. (NCT01684930)
Timeframe: Baseline and 16 weeks
Intervention | seconds (Mean) |
---|---|
BR Juice (Beet-It Stamina Shot) and Exercise Training | 199.22 |
BR Juice Placebo and Exercise Training | 48.58 |
Exercise capacity will be assessed using a maximal cardiopulmonary exercise (CPX) test with expired gas analysis, for determination of peak oxygen consumption, claudication onset time and peak walking time. (NCT01684930)
Timeframe: Baseline and 16 Weeks
Intervention | ml/kg/min (Mean) |
---|---|
BR Juice (Beet-It Stamina Shot) and Exercise Training | 1.48 |
BR Juice Placebo and Exercise Training | 0.23 |
Six-Minute Walk test. This test simple and practical assessment of functional capacity. The test measures the distance that a patient can walk on a flat, hard surface in a period of 6 minutes. The test is self-paced and assesses the submaximal level of functional capacity. The subjects choose their own intensity and are allowed to stop and rest if necessary during the test. (NCT01684930)
Timeframe: Baseline and 16 Weeks
Intervention | feet (Mean) |
---|---|
BR Juice (Beet-It Stamina Shot) and Exercise Training | 172.89 |
BR Juice Placebo and Exercise Training | 95 |
Exercise capacity will be assessed using a maximal cardiopulmonary exercise (CPX) test with expired gas analysis, for determination of total time to exhaustion. (NCT01684930)
Timeframe: Baseline and 16 weeks
Intervention | seconds (Mean) |
---|---|
BR Juice (Beet-It Stamina Shot) and Exercise Training | 289.56 |
BR Juice Placebo and Exercise Training | 254.92 |
Vascular Function is measured as Brachial artery flow-mediated dilation (BAFMD). BAFMD is a measure of change in artery diameter after a stimulus . (NCT01684930)
Timeframe: Baseline and 16 weeks
Intervention | % dilation (Mean) |
---|---|
BR Juice (Beet-It Stamina Shot) and Exercise Training | -1.14 |
BR Juice Placebo and Exercise Training | -0.19 |
Gastrocnemious muscle biopsy will be performed to measure the number of capillaries per fibre as a marker of change in angiogenesis between groups. (NCT01785524)
Timeframe: Baseline and 16 weeks
Intervention | ratio of capillaries to muscle fibres (Mean) |
---|---|
BR Juice (Beet-It Stamina Shot) & Supervised Exercise Training | 2 |
Exercise capacity will be assessed using a maximal cardiopulmonary exercise (CPX) test for determination of Claudication Onset Time (COT) (NCT01785524)
Timeframe: Baseline & 16 Weeks
Intervention | seconds (Mean) |
---|---|
BR Juice (Beet-It Stamina Shot) & Supervised Exercise Training | 189 |
BR Juice Placebo and Exercise Training | 77.5 |
Exercise capacity will be assessed using a maximal cardiopulmonary exercise (CPX) test with expired gas analysis, for determination of peak oxygen consumption (NCT01785524)
Timeframe: Baseline & 16 Weeks
Intervention | ml/kg/min (Mean) |
---|---|
BR Juice (Beet-It Stamina Shot) & Supervised Exercise Training | 0.85 |
BR Juice Placebo and Exercise Training | -0.15 |
Exercise capacity will be assessed using a maximal cardiopulmonary exercise (CPX) test for determination of Time to Exhaustion (TTE) (NCT01785524)
Timeframe: Baseline & 16 Weeks
Intervention | seconds (Mean) |
---|---|
BR Juice (Beet-It Stamina Shot) & Supervised Exercise Training | 196.25 |
BR Juice Placebo and Exercise Training | 247.5 |
Six-Minute Walk test. This test simple and practical assessment of functional capacity. The test measures the distance that a patient can walk on a flat, hard surface in a period of 6 minutes. The test is self-paced and assesses the submaximal level of functional capacity. The subjects choose their own intensity and are allowed to stop and rest if necessary during the test. (NCT01785524)
Timeframe: Baseline and 16 Weeks
Intervention | feet (Mean) |
---|---|
BR Juice (Beet-It Stamina Shot) & Supervised Exercise Training | 131 |
BR Juice Placebo and Exercise Training | 47.5 |
Vascular Function will be measured as the Brachial artery flow-mediated dilation (BAFMD) (NCT01785524)
Timeframe: Baseline and 16 weeks
Intervention | change % dilation (Number) |
---|---|
BR Juice (Beet-It Stamina Shot) & Supervised Exercise Training | 1.83 |
BR Juice Placebo and Exercise Training | -3.56 |
7 trials available for nitrites and Intermittent Claudication
Article | Year |
---|---|
Beet the Best?
Topics: Aged; Beta vulgaris; Biomarkers; Double-Blind Method; Exercise Therapy; Exercise Tolerance; Female; | 2018 |
Beet the Best?
Topics: Aged; Beta vulgaris; Biomarkers; Double-Blind Method; Exercise Therapy; Exercise Tolerance; Female; | 2018 |
Beet the Best?
Topics: Aged; Beta vulgaris; Biomarkers; Double-Blind Method; Exercise Therapy; Exercise Tolerance; Female; | 2018 |
Beet the Best?
Topics: Aged; Beta vulgaris; Biomarkers; Double-Blind Method; Exercise Therapy; Exercise Tolerance; Female; | 2018 |
A session of resistance exercise increases vasodilation in intermittent claudication patients.
Topics: Aged; Endothelium, Vascular; Female; Humans; Hyperemia; Hypertension; Intermittent Claudication; Leg | 2015 |
Acute effects of walking and combined exercise on oxidative stress and vascular function in peripheral artery disease.
Topics: Aged; Ankle Brachial Index; Biomarkers; Blood Pressure; Female; Hemodynamics; Humans; Hyperemia; Int | 2018 |
Long-term individual shear rate therapy counterpulsation enhances plasma nitrite release in patients with PAD.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Counterpulsation; Cross-Over Studies; Exerci | 2017 |
Intermittent pneumatic compression in stable claudicants: effect on hemostasis and endothelial function.
Topics: Adult; Aged; Antithrombin III; Biomarkers; Blood Coagulation; Endothelium, Vascular; Exercise Tolera | 2009 |
Plasma nitrite flux predicts exercise performance in peripheral arterial disease after 3months of exercise training.
Topics: Athletic Performance; Brachial Artery; Electrocardiography; Endothelium, Vascular; Exercise Test; Ex | 2010 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Ankle Brachial Index; Beta vulgaris; Beverages; Blood | 2011 |
1 other study available for nitrites and Intermittent Claudication
Article | Year |
---|---|
[Bloodless treatment of gangrene of the legs & intermittent claudication by intravenous sodium nitrite].
Topics: Gangrene; Humans; Intermittent Claudication; Leg; Nitrites; Sodium Nitrite | 1958 |