nitrites has been researched along with Hypertension in 322 studies
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mercury is considered a risk factor for the development of hypertension and other cardiovascular diseases." | 9.51 | Oxidative Stress Induced by 30 Days of Mercury Exposure Accelerates Hypertension Development in Prehypertensive Young SHRs. ( Leal, MAS; Padilha, AS; Peçanha, GAW; Ronchetti, GZ; Schereider, IRG; Simões, MR; Vassallo, DV, 2022) |
| "The objective was to assess the effect of propranolol on oxidative stress and anti-oxidant potential in patients with resistant hypertension as a secondary analysis of the APPROPRIATE trial." | 9.34 | The impact of propranolol on nitric oxide and total antioxidant capacity in patients with resistant hypertension-evidence from the APPROPRIATE trial. ( Constantine, GR; Fernando, N; Galappatthy, P; Handunnetti, S; Katulanda, P; Rajapakse, S; Ranasinghe, HN; Weeratunga, PN, 2020) |
| " The aim of the present study was to determine the effect of hypotensive therapy with a diuretic (hydrochlorothiazide) and an angiotensin-converting enzyme inhibitor (perindopril) on selected oxidative stress parameters in the blood of elderly patients with essential hypertension." | 9.12 | Effects of perindopril and hydrochlorothiazide on selected indices of oxidative stress in the blood of elderly patients with essential hypertension. ( Czuczejko, J; Kedziora, J; Kedziora-Kornatowska, K; Kornatowski, T; Motyl, J; Pawluk, H; Szadujkis-Szadurski, L; Szewczyk-Golec, K, 2006) |
| "It is controversial that uric acid (UA) levels are related to the severity of hypertension in preeclampsia (PE)." | 7.83 | The relationship between hypertension and plasma allantoin, uric acid, xanthine oxidase activity and nitrite, and their predictive capacity in severe preeclampsia. ( Aliciguzel, Y; Elmas, O; Simsek, T, 2016) |
| "The effect of ellagic acid on oxidative stress and hypertension induced by Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) was investigated." | 7.81 | Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47phox Expression in Rats. ( Berkban, T; Boonprom, P; Bunbupha, S; Kukongviriyapan, U; Kukongviriyapan, V; Pakdeechote, P; Prachaney, P; Welbat, JU, 2015) |
| "Fructose-induced hypertension was used to test the hypothesis that taurine supplementation and/or exercise can prevent hypertension and increase exercise capacity." | 7.77 | Taurine prevents hypertension and increases exercise capacity in rats with fructose-induced hypertension. ( Go, HK; Hong, CU; Kang, HS; Kim, GB; Kim, JS; Kim, SJ; Kim, SZ; Lee, YU; Park, HM; Rahman, MM, 2011) |
| "Endothelin (ET) receptor antagonists are antihypertensive and renoprotective in angiotensin II (AngII)-induced hypertension if administered when AngII infusion commences, but their effects on established hypertension are poorly understood." | 7.76 | Contrasting effects of intervention with ETA and ETB receptor antagonists in hypertension induced by angiotensin II and high-salt diet. ( Boesen, EI; Pollock, DM; Pollock, JS, 2010) |
| "Population studies indicate that moderate hyperbilirubinemia is associated with reduced incidence of cardiovascular diseases, including hypertension." | 7.75 | Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice. ( Granger, JP; Stec, DE; Vera, T, 2009) |
| "Tea catechin ingestion significantly delayed stroke onset by 10 days compared to the control group." | 7.74 | Preventive effects of green tea catechins on spontaneous stroke in rats. ( Ikeda, M; Saito, K; Suzuki, C; Tabuchi, M; Tomita, T; Umegaki, K, 2007) |
| "The study was carried out on 37 patients (69-91 yrs) with primary hypertension, treated with perindopril for 6 weeks, and normotensive subjects who constituted the two control groups: 25 (65-96 yrs--K1) and 23 (22-41 yrs--K2)." | 7.73 | Production of nitric oxide, lipid peroxidation and oxidase activity of ceruloplasmin in blood of elderly patients with primary hypertension. Effects of perindopril treatment. ( Bartosz, G; Czuczejko, J; Kedziora, J; Kedziora-Kornatowska, K; Kornatowski, T; Pawluk, H; Szadujkis-Szadurski, L, 2006) |
| "To assess the antioxidant effects of atorvastatin (atorva) on dexamethasone (dex)-induced hypertension, 60 male Sprague-Dawley rats were treated with atorva 30 mg/kg/day or tap water for 15 days." | 7.73 | Atorvastatin prevented and reversed dexamethasone-induced hypertension in the rat. ( Huang, TG; Mondo, CK; Su, JZ; Yang, WS, 2006) |
| "Hyperhomocysteinemia is often associated with an increase in blood pressure." | 7.72 | Opposite effect of methionine-supplemented diet, a model of hyperhomocysteinemia, on plasma and liver antioxidant status in normotensive and spontaneously hypertensive rats. ( Berthelot, A; Courderot-Masuyer, C; Jacqueson, A; Nicod, L; Richert, L; Robin, S, 2004) |
| "Chronic exposure to low levels of lead causes hypertension (HTN) that is, in part, due to increased inactivation of nitric oxide (NO) by reactive oxygen species (ROS)." | 7.71 | Compensatory up-regulation of nitric-oxide synthase isoforms in lead-induced hypertension; reversal by a superoxide dismutase-mimetic drug. ( Ding, Y; Ni, Z; Vaziri, ND, 2001) |
| "Cyclosporine A (CsA) is an immunosuppressive agent that also causes hypertension." | 7.70 | Role of nitric oxide in cyclosporine A-induced hypertension. ( Keiser, HR; Oriji, GK, 1998) |
| "Cyclosporine A (CsA) is an immunosuppressive agent, which also causes hypertension." | 7.70 | Nitric oxide in cyclosporine A-induced hypertension: endothelin receptors gene expression. ( Oriji, GK, 1999) |
| "The haemodynamic features of ACTH-induced hypertension were reproduced by corticosterone excess, at concentrations of corticosterone similar to those in studies of exogenous ACTH administration." | 7.70 | The role of corticosterone in corticotrophin (ACTH)-induced hypertension in the rat. ( Fraser, TB; Mangos, GJ; Turner, SW; Whitworth, JA, 2000) |
| "L-arginine treatment prevents adrenocorticotrophin (ACTH) induced hypertension in the rat." | 7.70 | L-arginine partially reverses established adrenocorticotrophin-induced hypertension and nitric oxide deficiency in the rat. ( Fraser, T; Li, M; Turner, SW; Wang, J; Wen, C; Whitworth, JA, 2000) |
| "L-arginine (L-Arg) was administered intravenously through 4 consecutive days to 20 males (40-63 years old) with essential hypertension (EH)." | 7.69 | Effects of prolonged L-arginine administration on blood pressure in patients with essential hypertension (EH). ( Czarnecka, D; Dembinska-Kiec, A; Goldsztajn, P; Kawecka-Jaszcz, K; Malczewska-Malec, M; Siedlecki, A; Siemienska, T, 1995) |
| "Chronic exposure to low levels of lead results in sustained hypertension (HTN) in humans and experimental animals." | 7.69 | Altered nitric oxide metabolism and increased oxygen free radical activity in lead-induced hypertension: effect of lazaroid therapy. ( Ding, Y; Gonick, HC; Ni, Z; Vaziri, ND, 1997) |
| " A potential reason for this is reduced nitric oxide bioavailability in African Americans, resulting in increased prevalence of factors that contribute to ventricular dysfunction." | 6.77 | Vascular effects of nebivolol added to hydrochlorothiazide in African Americans with hypertension and echocardiographic evidence of diastolic dysfunction: the NASAA study. ( Bhaheetharan, S; Ferdinand, KC; Haque, T; Harris, J; Khan, BV; Merchant, N; Rahman, ST; Umar, K; Wahi, J, 2012) |
| "Treatment with enalapril decreased blood pressure in hypertensive patients." | 6.76 | Antihypertensive effects exerted by enalapril in mild to moderate hypertension are not associated with changes in the circulating levels of nitric oxide-related markers. ( Biagi, C; Fontana, V; Palei, ACT; Sertório, JTC; Silva, PS; Tanus-Santos, JE, 2011) |
| "Nitrites/nitrates were significantly lower (P < 0." | 6.72 | Effect of doxazosin on C-reactive protein plasma levels and on nitric oxide in patients with hypertension. ( Ciccarelli, L; Cicero, AF; D'Angelo, A; Derosa, G; Ferrari, I; Fogari, R; Galli, S; Gravina, A; Montagna, L; Paniga, S; Piccinni, MN; Pricolo, F; Salvadeo, S; Tinelli, C, 2006) |
| "Mercury is considered a risk factor for the development of hypertension and other cardiovascular diseases." | 5.51 | Oxidative Stress Induced by 30 Days of Mercury Exposure Accelerates Hypertension Development in Prehypertensive Young SHRs. ( Leal, MAS; Padilha, AS; Peçanha, GAW; Ronchetti, GZ; Schereider, IRG; Simões, MR; Vassallo, DV, 2022) |
| "Although, several drugs are used to treat hypertension, the success of the antihypertensive therapy is limited." | 5.42 | Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension. ( Akcali, KC; Ayaloglu-Butun, F; Demirel-Yilmaz, E; Han, S; Uludag, MO; Usanmaz, SE, 2015) |
| "Hypertension is a common disease that includes oxidative stress as a major feature, and oxidative stress impairs physiological nitric oxide (NO) activity promoting cardiovascular pathophysiological mechanisms." | 5.42 | Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension. ( Amaral, JH; Ferreira, GC; Montenegro, MF; Pinheiro, LC; Tanus-Santos, JE, 2015) |
| " We evaluated the antihypertensive effects of sodium nitrite given in drinking water for 4 weeks in two-kidney one-clip (2K1C) hypertensive rats and the effects induced by nitrite on NO bioavailability and oxidative stress." | 5.37 | Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension. ( Amaral, JH; Ferreira, GC; Marçal, DM; Montenegro, MF; Pereira, RP; Pinheiro, LC; Reis, RI; Sakamoto, EK; Tanus-Santos, JE, 2011) |
| "Treatment with captopril was also performed in SHR in order to compare the antioxidant and antihypertensive effects of LC and captopril." | 5.36 | Systemic antioxidant properties of L-carnitine in two different models of arterial hypertension. ( Mate, A; Miguel-Carrasco, JL; Monserrat, MT; Vázquez, CM, 2010) |
| "Melatonin treatment of IH-exposed animals decreased blood pressure, blood glucose, and ROS and nitrite/nitrate levels, and increased vasodilation and capillary perfusion." | 5.35 | Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia. ( Bertuglia, S; Reiter, RJ, 2009) |
| "The objective was to assess the effect of propranolol on oxidative stress and anti-oxidant potential in patients with resistant hypertension as a secondary analysis of the APPROPRIATE trial." | 5.34 | The impact of propranolol on nitric oxide and total antioxidant capacity in patients with resistant hypertension-evidence from the APPROPRIATE trial. ( Constantine, GR; Fernando, N; Galappatthy, P; Handunnetti, S; Katulanda, P; Rajapakse, S; Ranasinghe, HN; Weeratunga, PN, 2020) |
| " We therefore studied the effect of acute and chronic administration of l-arginine (a substrate for endothelial nitric oxide synthase) on the renal hemodynamic and vascular structural alterations induced by HU." | 5.34 | Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. ( Avila-Casado, C; Franco, M; Herrera-Acosta, J; Johnson, RJ; López-Molina, R; Nakagawa, T; Nepomuceno, T; Sánchez-Lozada, LG; Soto, V; Tapia, E, 2007) |
| "Thus, acute euglycemic hyperinsulinemia produces a decrease in plasma ET-1 in both EH patients and controls." | 5.30 | Effects of acute euglycemic hyperinsulinemia on urinary nitrite/nitrate excretion and plasma endothelin-1 levels in men with essential hypertension and normotensive controls. ( Dubiel, JS; Froelich, JC; Kokot, F; Kruszelnicka-Kwiatkowska, O; Nowicki, M; Sandmann, J; Surdacki, A; Tsikas, D, 1999) |
| " The aim of this study was to analyse the effects of a single session of resistance exercise on blood flow, reactive hyperemia, plasma nitrite, and plasma malondialdehyde in patients with peripheral artery disease." | 5.20 | A session of resistance exercise increases vasodilation in intermittent claudication patients. ( Brasileiro-Santos, M; Correia, M; Forjaz, CL; Lima, A; Miranda, A; Ritti-Dias, R; Santos, A; Silva, A; Sobral Filho, D, 2015) |
| " The aim of the present study was to determine the effect of hypotensive therapy with a diuretic (hydrochlorothiazide) and an angiotensin-converting enzyme inhibitor (perindopril) on selected oxidative stress parameters in the blood of elderly patients with essential hypertension." | 5.12 | Effects of perindopril and hydrochlorothiazide on selected indices of oxidative stress in the blood of elderly patients with essential hypertension. ( Czuczejko, J; Kedziora, J; Kedziora-Kornatowska, K; Kornatowski, T; Motyl, J; Pawluk, H; Szadujkis-Szadurski, L; Szewczyk-Golec, K, 2006) |
| "The sulfhydryl ACE inhibitor zofenopril reduces oxidative stress and improves the NO pathway in patients with essential hypertension." | 5.11 | Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension. ( Condorelli, M; de Nigris, F; Ignarro, LJ; Liguori, A; Napoli, C; Pignalosa, O; Sica, V, 2004) |
| "Patients with essential hypertension (n = 24) were administered a low-salt diet (2 g NaCl/day), a high-salt diet (20-23 g) and then a low-salt diet for 7 days, and plasma levels of nitrate and nitrite (NOx) and asymmetric dimethylarginine (ADMA) were examined." | 5.10 | Relationship between salt intake, nitric oxide and asymmetric dimethylarginine and its relevance to patients with end-stage renal disease. ( Fujiwara, N; Nakamura, M; Okumura, K; Osanai, T; Osawa, H; Saitoh, M; Sasaki, S; Tomita, H; Yamabe, H, 2002) |
| "We discovered that in the patients with chronic coronary heart disease (CHD) the mean value of nitrites was 18 +/- 0." | 4.79 | Nitrite plasma levels in acute and chronic coronary heart disease. ( Ferlito, S; Gallina, M, 1997) |
| "It is controversial that uric acid (UA) levels are related to the severity of hypertension in preeclampsia (PE)." | 3.83 | The relationship between hypertension and plasma allantoin, uric acid, xanthine oxidase activity and nitrite, and their predictive capacity in severe preeclampsia. ( Aliciguzel, Y; Elmas, O; Simsek, T, 2016) |
| " The widely distributed amino acid taurine seems to be an effective depressor agent in drug-induced hypertension." | 3.83 | Impact of chronic administration of anabolic androgenic steroids and taurine on blood pressure in rats. ( Badiu, C; Căruntu, C; Gaman, L; Iosif, L; Mirica, R; Popescu, BO; Roşca, AE; Stancu, CS; Stoian, I; Tivig, IC; Voiculescu, SE; Zăgrean, L, 2016) |
| "Here we show that wild-type mice infused with angiotensin II develop hypertension, cardiac hypertrophy, perivascular fibrosis, and endothelial dysfunction with enhanced stromal interaction molecule 1 (STIM1) expression in heart and vessels." | 3.83 | Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular Dysfunction. ( Ait-Aissa, K; Belmadani, S; Gabani, M; Haddox, S; Irani, K; Kassan, M; Mali, V; Matrougui, K; Radwan, E; Trebak, M; Zhang, W, 2016) |
| "The effect of ellagic acid on oxidative stress and hypertension induced by Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) was investigated." | 3.81 | Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47phox Expression in Rats. ( Berkban, T; Boonprom, P; Bunbupha, S; Kukongviriyapan, U; Kukongviriyapan, V; Pakdeechote, P; Prachaney, P; Welbat, JU, 2015) |
| " The electrophilic lipid 10-nitro-oleic acid (NO2-OA) inhibited hydrolase activity and also lowered BP in an angiotensin II-induced hypertension model in wild-type (WT) but not KI mice." | 3.80 | Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. ( Charles, RL; Eaton, P; Freeman, BA; Hammock, BD; Kamynina, A; Morisseau, C; Prysyazhna, O; Rudyk, O; Yang, J, 2014) |
| "To study characteristics of hemodynamics, spectral analysis of heart rate variability (HRV) and their association with the total blood concentration of stable metabolites of nitric oxide (nitrites and nitrates) in patients with hypertension living in highlands." | 3.80 | [Adaptative resources of the main regulatory systems in patients with hypertension under the highland conditions]. ( Batyrbekova, LM; Beslaneev, IA; Kurdanov, KhA; Kurdanova, MKh, 2014) |
| "The present study was aimed to evaluate the antihypertensive effect of diosmin in deoxycorticosterone acetate (DOCA)-salt induced hypertension in male Wistar rats." | 3.78 | Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats. ( Raja, B; Silambarasan, T, 2012) |
| "The present study was designed to evaluate the antihypertensive and antioxidant effect of morin, a flavonoid against deoxycorticosterone acetate (DOCA)-salt induced hypertension in male Wistar rats." | 3.78 | Morin attenuates blood pressure and oxidative stress in deoxycorticosterone acetate-salt hypertensive rats: a biochemical and histopathological evaluation. ( Kumar, S; Prahalathan, P; Raja, B, 2012) |
| "We investigated the effects of extraendothelial nitric oxide (NO) on angiotensin II (Ang II) reactivity in internal mammary artery (IMA) rings, as well as the impact of hypertension without associated risk factors in this response." | 3.77 | Nitric oxide modulates reactivity to angiotensin II in internal mammary arterial grafts in hypertensive patients without associated risk factors. ( de Bruno, MP; Herrera, R; Marañón, RO; Proto, V; Turoni, CJ, 2011) |
| "Fructose-induced hypertension was used to test the hypothesis that taurine supplementation and/or exercise can prevent hypertension and increase exercise capacity." | 3.77 | Taurine prevents hypertension and increases exercise capacity in rats with fructose-induced hypertension. ( Go, HK; Hong, CU; Kang, HS; Kim, GB; Kim, JS; Kim, SJ; Kim, SZ; Lee, YU; Park, HM; Rahman, MM, 2011) |
| "Minoxidil (2,4-diamino-6-(piperidin-1'-yl)pyrimidine N(3)-oxide; CASRN 38304-91-5) is a bioactive molecule with several nitrosatable groups widely used as an antihypertensive and antialopecia agent." | 3.77 | Aromatic C-nitrosation of a bioactive molecule. Nitrosation of minoxidil. ( Arenas-Valgañón, J; Calle, E; Casado, J; González-Jiménez, M, 2011) |
| "Endothelin (ET) receptor antagonists are antihypertensive and renoprotective in angiotensin II (AngII)-induced hypertension if administered when AngII infusion commences, but their effects on established hypertension are poorly understood." | 3.76 | Contrasting effects of intervention with ETA and ETB receptor antagonists in hypertension induced by angiotensin II and high-salt diet. ( Boesen, EI; Pollock, DM; Pollock, JS, 2010) |
| " The aim of the study was to assess nitric oxide metabolites concentration (nitrites and nitrates No(x)) and endothelin (ET-1) in plasma and cyclic 3,5-guanosine monophosphate (cGMP) in 24 h-urine collection in patients with noncomplicated hypertension without risk factors of atherosclerosis and in hypertensive patients with coronary artery disease (CAD)." | 3.75 | Endothelial dysfunction in patients with noncomplicated and complicated hypertension. ( Banach, M; Goch, A; Goch, JH; Mikhailidis, DP; Rysz, J, 2009) |
| "This study investigated the association between nephropathy and oxidative stress, by measurement of systolic blood pressure, lipid peroxidation, activities of catalase, manganese- and copper-zinc-superoxide dismutase and endothelial nitric oxide synthase expression and concentrations of nitrates/nitrites in kidneys from rats with Metabolic Syndrome." | 3.75 | Association of renal damage and oxidative stress in a rat model of metabolic syndrome. Influence of gender. ( Baños, G; Diaz-Diaz, E; El Hafidi, M; Pérez-Torres, I; Roque, P, 2009) |
| "Population studies indicate that moderate hyperbilirubinemia is associated with reduced incidence of cardiovascular diseases, including hypertension." | 3.75 | Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice. ( Granger, JP; Stec, DE; Vera, T, 2009) |
| "Experimental NO deficiency induced by L-NAME injection led to the development of arterial hypertension, endothelial dysfunction, and cardiomyocyte hypertrophy and reduced blood content of nitrates and nitrites." | 3.75 | Comparative study of potential endothelioprotectors and impaza in modeled nitric oxide deficiency. ( Artyushkova, EB; Belous, AS; Brusnik, MS; Danilenko, LM; Kochkarov, VI; Korokin, MV; Korokina, LV; Malykhin, VA; Pashin, EN; Pokrovskaya, TG; Pokrovskii, MV; Zaloznykh, YI; Zhavbert, ES, 2009) |
| "Tea catechin ingestion significantly delayed stroke onset by 10 days compared to the control group." | 3.74 | Preventive effects of green tea catechins on spontaneous stroke in rats. ( Ikeda, M; Saito, K; Suzuki, C; Tabuchi, M; Tomita, T; Umegaki, K, 2007) |
| "The study was carried out on 37 patients (69-91 yrs) with primary hypertension, treated with perindopril for 6 weeks, and normotensive subjects who constituted the two control groups: 25 (65-96 yrs--K1) and 23 (22-41 yrs--K2)." | 3.73 | Production of nitric oxide, lipid peroxidation and oxidase activity of ceruloplasmin in blood of elderly patients with primary hypertension. Effects of perindopril treatment. ( Bartosz, G; Czuczejko, J; Kedziora, J; Kedziora-Kornatowska, K; Kornatowski, T; Pawluk, H; Szadujkis-Szadurski, L, 2006) |
| "To assess the antioxidant effects of atorvastatin (atorva) on dexamethasone (dex)-induced hypertension, 60 male Sprague-Dawley rats were treated with atorva 30 mg/kg/day or tap water for 15 days." | 3.73 | Atorvastatin prevented and reversed dexamethasone-induced hypertension in the rat. ( Huang, TG; Mondo, CK; Su, JZ; Yang, WS, 2006) |
| " However, nipradilol, at doses of 10 and 15 mg/kg/day, significantly decreased proteinuria and glomerulosclerosis, while propranolol did not." | 3.72 | A nitric oxide-generating beta-blocking agent prevents renal injury in the rat remnant kidney model. Comparative study of two beta-blocking drugs, nipradilol and propranolol. ( Hasuike, Y; Hiraoka, K; Inoue, T; Itahana, R; Izumi, M; Miyagawa, K; Nakanishi, T; Nishihara, F; Takamitsu, Y, 2003) |
| " We investigated the factors involved in the development of hypertension induced by LPD in rats with post-cyclosporine (CsA) nephropathy, and determined the appropriate composition for LPD that is to be utilized for renal research." | 3.72 | Factors involved in the development of hypertension induced by a low-protein diet in rats with renal injury. ( Endoh, M; Ikegaya, N; Kumagai, H; Odamaki, M, 2004) |
| "Hyperhomocysteinemia is often associated with an increase in blood pressure." | 3.72 | Opposite effect of methionine-supplemented diet, a model of hyperhomocysteinemia, on plasma and liver antioxidant status in normotensive and spontaneously hypertensive rats. ( Berthelot, A; Courderot-Masuyer, C; Jacqueson, A; Nicod, L; Richert, L; Robin, S, 2004) |
| "In this study, to test the hypothesis that leptin regulation of NO metabolism is impaired in hypertension, we examined the possible relationship between circulating leptin and plasma NO metabolite level in normotensive (NT) and hypertensive (HT) men." | 3.72 | Leptin and nitric oxide production in normotensive and hypertensive men. ( Nishio, I; Tsuda, K, 2004) |
| "The expression of HO-1 and iNOS in aorta increased with the SBP elevation during the development of SHR and was attenuated when the hypertension was lowered with the vasodilator hydralazine." | 3.72 | The expression of heme oxygenase-1 and inducible nitric oxide synthase in aorta during the development of hypertension in spontaneously hypertensive rats. ( Chen, JJ; Cheng, PY; Yen, MH, 2004) |
| "Losartan, an angiotensin II type-1 receptor (AT1) antagonist, was used to investigate whether it can offer protection against the sustained hypertension, cardiac hypertrophy, and renal damage induced by chronic inhibition of nitric oxide (NO) by Nomega-nitro-L-arginine methyl ester (L-NAME)." | 3.72 | Effects of losartan on blood pressure, oxidative stress, and nitrate/nitrite levels in the nitric oxide deficient hypertensive rats. ( Ahmad, M; Al-Shabanah, OA; Khattab, M; Raza, M, 2004) |
| "To clarify whether endothelium-derived contracting factor (EDCF) is developed in renal artery of hypertensive Dahl rats and whether prolonged oral L-arginine treatments prevent development of EDCF and hypertension." | 3.71 | L-Arginine improves endothelial function in renal artery of hypertensive Dahl rats. ( Abe, Y; Chen, QH; Kosaka, H; Tian, RX; Yamamoto, A; Yoneyama, H; Zhang, L; Zhou, MS, 2001) |
| " This study investigated the effect of omapatrilat in comparison to the ACE inhibitor captopril on systolic blood pressure and endothelial function in salt-induced hypertension." | 3.71 | Vasopeptidase inhibition exhibits endothelial protection in salt-induced hypertension. ( d'Uscio, LV; Lüscher, TF; Quaschning, T; Shaw, S, 2001) |
| " Celiprolol (DOCA-CEL, n = 9, 10 mg/kg per day, subdepressor dose) or a vehicle (DOCA-V, n = 9) were given after induction of DOCA-salt hypertension for 5 weeks, and age-matched sham-operated rats (ShC, n = 9) served as a control group." | 3.71 | Celiprolol stimulates endothelial nitric oxide synthase expression and improves myocardial remodeling in deoxycorticosterone acetate-salt hypertensive rats. ( Kobayashi, N; Matsuoka, H; Mori, Y; Nakano, S; Shirataki, H; Tsubokou, Y, 2001) |
| "Chronic exposure to low levels of lead causes hypertension (HTN) that is, in part, due to increased inactivation of nitric oxide (NO) by reactive oxygen species (ROS)." | 3.71 | Compensatory up-regulation of nitric-oxide synthase isoforms in lead-induced hypertension; reversal by a superoxide dismutase-mimetic drug. ( Ding, Y; Ni, Z; Vaziri, ND, 2001) |
| "Angiotensin II (Ang II) plays an important role as a modulator of vascular structure and function in arterial hypertension." | 3.71 | TCV-116 stimulates eNOS and caveolin-1 expression and improves coronary microvascular remodeling in normotensive and angiotensin II-induced hypertensive rats. ( Kobayashi, N; Kobayashi, T; Matsuoka, H; Mori, Y; Nakano, S; Shirataki, H; Tsubokou, Y, 2001) |
| "The available data on the role of the L-arginine/nitric oxide (NO) pathway in the genesis of hypertension in spontaneously hypertensive rats (SHR) are limited and contradictory." | 3.70 | Upregulation of renal and vascular nitric oxide synthase in young spontaneously hypertensive rats. ( Ni, Z; Oveisi, F; Vaziri, ND, 1998) |
| "Cyclosporine A (CsA) is an immunosuppressive agent that also causes hypertension." | 3.70 | Role of nitric oxide in cyclosporine A-induced hypertension. ( Keiser, HR; Oriji, GK, 1998) |
| "Cyclosporine A (CsA) is an immunosuppressive agent, which also causes hypertension." | 3.70 | Nitric oxide in cyclosporine A-induced hypertension: endothelin receptors gene expression. ( Oriji, GK, 1999) |
| "The haemodynamic features of ACTH-induced hypertension were reproduced by corticosterone excess, at concentrations of corticosterone similar to those in studies of exogenous ACTH administration." | 3.70 | The role of corticosterone in corticotrophin (ACTH)-induced hypertension in the rat. ( Fraser, TB; Mangos, GJ; Turner, SW; Whitworth, JA, 2000) |
| "L-arginine treatment prevents adrenocorticotrophin (ACTH) induced hypertension in the rat." | 3.70 | L-arginine partially reverses established adrenocorticotrophin-induced hypertension and nitric oxide deficiency in the rat. ( Fraser, T; Li, M; Turner, SW; Wang, J; Wen, C; Whitworth, JA, 2000) |
| " This study analyses the contribution of the precursor L-arginine (L-arg) by oral administration in two kidney-two clip hypertension in the rat (2K-2C)." | 3.70 | Effect of oral L-arginine administration for three weeks in two kidney-two clip hypertensive rats. ( Albornoz, LE; Damiano, PF; de la Riva, IJ; Ferrero, AJ; Palumbo, EL; Rosón, MI; Speziale, N; Vega, GW, 2000) |
| "L-arginine (L-Arg) was administered intravenously through 4 consecutive days to 20 males (40-63 years old) with essential hypertension (EH)." | 3.69 | Effects of prolonged L-arginine administration on blood pressure in patients with essential hypertension (EH). ( Czarnecka, D; Dembinska-Kiec, A; Goldsztajn, P; Kawecka-Jaszcz, K; Malczewska-Malec, M; Siedlecki, A; Siemienska, T, 1995) |
| "In order to clarify the mechanism of hypertension induced by a nitric oxide (NO) synthase inhibitor, L-NG-nitro-L-arginine (LNNA), metabolites of NO, catecholamines, and hemodynamic parameters were measured during 7 days of oral administration of LNNA in rats." | 3.69 | Mechanism of hypertension induced by chronic inhibition of nitric oxide in rats. ( Hara, K; Komiyama, Y; Masuda, M; Murakami, T; Nambu, A; Nishimura, M; Takahashi, H; Yoshimura, M, 1995) |
| "Chronic exposure to low levels of lead results in sustained hypertension (HTN) in humans and experimental animals." | 3.69 | Altered nitric oxide metabolism and increased oxygen free radical activity in lead-induced hypertension: effect of lazaroid therapy. ( Ding, Y; Gonick, HC; Ni, Z; Vaziri, ND, 1997) |
| " nitroglycerin (ivGTN) on the haemodynamic response to phenylephrine-induced hypertension (PEHT) in anaesthetized pigs." | 3.69 | Extra-pulmonary effects of inhaled nitric oxide in swine with and without phenylephrine. ( Blaise, G; Charbonneau, M; Francoeur, M; Leclerc, G; Salazkin, I; Troncy, E; Vinay, P; Yang, F, 1997) |
| "L-Arginine, the precursor of endothelium-derived relaxing factor (EDRF)/nitric oxide (NO), was administered intravenously in five patients with essential hypertension, one with renovascular hypertension, one with primary aldosteronism, and one with Cushing's syndrome." | 3.68 | L-arginine as an antihypertensive agent. ( Hishikawa, K; Kato, R; Nakaki, T; Saruta, T; Suzuki, H, 1992) |
| "Intradialytic hypertension affects ∼15% of hemodialysis patients and is associated with increased morbidity and mortality." | 2.80 | Effect of low versus high dialysate sodium concentration on blood pressure and endothelial-derived vasoregulators during hemodialysis: a randomized crossover study. ( Allen, JD; D'Silva, K; Inrig, JK; Kim, C; Molina, C; Toto, R; Van Buren, P, 2015) |
| " A potential reason for this is reduced nitric oxide bioavailability in African Americans, resulting in increased prevalence of factors that contribute to ventricular dysfunction." | 2.77 | Vascular effects of nebivolol added to hydrochlorothiazide in African Americans with hypertension and echocardiographic evidence of diastolic dysfunction: the NASAA study. ( Bhaheetharan, S; Ferdinand, KC; Haque, T; Harris, J; Khan, BV; Merchant, N; Rahman, ST; Umar, K; Wahi, J, 2012) |
| " A single dose of Q aglycone reduces BP in hypertensive men through a mechanism that is independent of changes in ACE activity, ET-1, or nitric oxide bioavailability and without affecting vascular reactivity." | 2.77 | Acute, quercetin-induced reductions in blood pressure in hypertensive individuals are not secondary to lower plasma angiotensin-converting enzyme activity or endothelin-1: nitric oxide. ( Bruno, RS; Guo, Y; Ives, S; Jalili, T; Larson, A; Richardson, RS; Symons, JD; Witman, MA, 2012) |
| "Treatment with enalapril decreased blood pressure in hypertensive patients." | 2.76 | Antihypertensive effects exerted by enalapril in mild to moderate hypertension are not associated with changes in the circulating levels of nitric oxide-related markers. ( Biagi, C; Fontana, V; Palei, ACT; Sertório, JTC; Silva, PS; Tanus-Santos, JE, 2011) |
| " Besides these proteases, several investigations have demonstrated that reduced endogenous NO bioavailability is a central pathological event in hypertension." | 2.72 | Nitrate and nitrite-based therapy to attenuate cardiovascular remodelling in arterial hypertension. ( Batista, RIM; Guimaraes, DA; Tanus-Santos, JE, 2021) |
| "Nitrites/nitrates were significantly lower (P < 0." | 2.72 | Effect of doxazosin on C-reactive protein plasma levels and on nitric oxide in patients with hypertension. ( Ciccarelli, L; Cicero, AF; D'Angelo, A; Derosa, G; Ferrari, I; Fogari, R; Galli, S; Gravina, A; Montagna, L; Paniga, S; Piccinni, MN; Pricolo, F; Salvadeo, S; Tinelli, C, 2006) |
| "Essential hypertension has a familial predisposition, but the phenotype of elevated blood pressure has delayed penetrance." | 2.70 | Early alteration in glomerular reserve in humans at genetic risk of essential hypertension: mechanisms and consequences. ( Gabbai, FB; Henry, RR; Kailasam, MT; Martinez, JA; Miller, LM; O'Connor, DT; Parmer, RJ; Tyrell, EA, 2001) |
| "Moreover, reactive hyperemia evaluated by strain-gauge plethysmography after 6 months (1." | 2.70 | Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by noninvasive evaluation. ( Higaki, J; Jinno, T; Katsuya, T; Komai, N; Matsumoto, K; Moriguchi, A; Ogihara, T; Ohishi, M; Rakugi, H; Yanagitani, Y, 2002) |
| "Twenty-one were attending for treatment of hypertension and 17 were normotensive, attending for minor gastrointestinal complaints." | 2.68 | Combination oral antioxidant supplementation reduces blood pressure. ( Galley, HF; Howdle, PD; Thornton, J; Walker, BE; Webster, NR, 1997) |
| "Hypertension is usually associated with deficient nitric oxide (NO) bioavailability, and therefore stimulating NO activity is an important antihypertensive strategy." | 2.61 | Nitrite-stimulated Gastric Formation of S-nitrosothiols As An Antihypertensive Therapeutic Strategy. ( Oliveira-Paula, GH; Tanus-Santos, JE, 2019) |
| "Hypertension is a multifactorial disease associated with impaired nitric oxide (NO) production and bioavailability." | 2.61 | Mechanisms impairing blood pressure responses to nitrite and nitrate. ( Oliveira-Paula, GH; Pinheiro, LC; Tanus-Santos, JE, 2019) |
| " Conversely, reduced NO bioavailability is a central feature during natural ageing and in many cardiovascular disorders, including hypertension." | 2.58 | Mechanisms underlying blood pressure reduction by dietary inorganic nitrate. ( Carlström, M; Lundberg, JO; Weitzberg, E, 2018) |
| "Obesity, type 2 diabetes and the metabolic syndrome are associated with a decrease in NO bioavailability." | 2.53 | Dietary inorganic nitrate: From villain to hero in metabolic disease? ( Griffin, JL; McNally, B; Roberts, LD, 2016) |
| "Hypertension is common in black populations and is known to be associated with low nitric oxide (NO) bioavailability." | 1.62 | Urinary albumin-to-creatinine ratio is inversely related to nitric oxide synthesis in young black adults: the African-PREDICT study. ( Bollenbach, A; Craig, A; Kruger, R; Mels, CMC; Schutte, AE; Schwedhelm, E; Tsikas, D, 2021) |
| "Hypertension is a risk factor for erectile dysfunction (ED) and both conditions are associated with oxidative stress." | 1.56 | Treatment with nitrite prevents reactive oxygen species generation in the corpora cavernosa and restores intracavernosal pressure in hypertensive rats. ( Carneiro, FS; da Silva, CBP; do Vale, GT; Gonzaga, NA; Leite, LN; Pinheiro, LC; Tanus-Santos, JE; Tirapelli, CR, 2020) |
| " Obtained findings suggested that CLE was able to enhance nitric oxide bioavailability that might dampen the vasoconstriction effect of phenylephrine." | 1.51 | Effects of citrus leaf extract on aortic vascular reactivity in hypertensive rats fed repeatedly heated vegetable oil. ( Jaarin, K; Kamisah, Y; Mohamed, S; Siti, HN, 2019) |
| "Cardiac hypertrophy is a common consequence of chronic hypertension and leads to heart failure and premature death." | 1.48 | Nitrite exerts antioxidant effects, inhibits the mTOR pathway and reverses hypertension-induced cardiac hypertrophy. ( Amaral, JH; Castro, MM; Dos Passos, MA; Gerlach, RF; Guimaraes, DA; Pinheiro, LC; Rizzi, E; Tanus-Santos, JE, 2018) |
| "Dyslipidemia was showed by 52." | 1.48 | Relationship Between Erectile Dysfunction, Diabetes and Dyslipidemia in Hypertensive-Treated Men. ( Lahera, V; Lopez-Farre, AJ; Prieto, R; Puigvert, A; Rodriguez-Pardo, JM; Segura, A; Zamorano-Leon, JJ, 2018) |
| " Additionally, in the SHRtr group, superoxide levels were significantly decreased, nitric oxide bioavailability was improved, and the levels of the nicotinamide adenine dinucleotide oxidase subunit isoform 4 protein were decreased compared to the SHRsd group." | 1.46 | Aerobic Swim Training Restores Aortic Endothelial Function by Decreasing Superoxide Levels in Spontaneously Hypertensive Rats. ( Bechara, LRG; de Sousa, LGO; Fernandes, T; Jordão, CP; Oliveira, EM; Ramires, PR; Tanaka, LY, 2017) |
| "Nitroxyl anion (HNO) has recently become an emerging candidate in vascular regulation." | 1.46 | Nitroxyl Anion Mediates Relaxation in Mesenteric Arteries from Angiotensin II Hypertensive Mice. ( Labazi, H; Tostes, RC; Webb, RC; Wynne, BM, 2017) |
| "Hypertension was induced by L-N(G)-nitroarginine methyl ester (L-NAME) and hypercholesterolemia was induced by feeding rats with a diet containing 1% cholesterol." | 1.46 | Protective effect of the standardized extract of ginkgo biloba (EGb761) against hypertension with hypercholesterolemia-induced renal injury in rats: Insights in the underlying mechanisms. ( Abd-Eldayem, AM; Abdel-Zaher, AO; El-Refaiy, AEM; Farghaly, HSM, 2017) |
| " NO bioavailability in adult rats was reduced by systemic administration of L-NAME via tap water." | 1.46 | Effect of nitric oxide deficiency on the pulmonary PTHrP system. ( Bencsik, P; Brockhoff, B; Ferdinandy, P; Forst, S; Heger, J; Kiss, K; Schlüter, KD; Schreckenberg, R; Schulz, R, 2017) |
| "Arterial thrombosis was induced electrically in rats with renovascular hypertension by partial ligation of the left renal artery." | 1.43 | Role of xanthine oxidoreductase in the anti-thrombotic effects of nitrite in rats in vivo. ( Buczko, W; Chabielska, E; Chlopicki, S; Kaminski, T; Kramkowski, K; Leszczynska, A; Proniewski, B; Przyborowski, K; Rykaczewska, U; Sitek, B; Smolenski, RT; Zakrzewska, A, 2016) |
| "Nitrites were measured by fluorescence with 2,3-diaminonaphthalene and H2O2 was measured with carbon microsensors." | 1.43 | Potent antihypertensive effect of Hancornia speciosa leaves extract. ( Braga, FC; Cortes, SF; Lemos, VS; Silva, GC, 2016) |
| " Reduced NO bioavailability can induce hypertension via multiple mechanisms." | 1.43 | Effects of Dietary l-Arginine on Nitric Oxide Bioavailability in Obese Normotensive and Obese Hypertensive Subjects. ( Giam, B; Head, GA; Kaye, DM; Kuruppu, S; Rajapakse, NW, 2016) |
| "Although, several drugs are used to treat hypertension, the success of the antihypertensive therapy is limited." | 1.42 | Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension. ( Akcali, KC; Ayaloglu-Butun, F; Demirel-Yilmaz, E; Han, S; Uludag, MO; Usanmaz, SE, 2015) |
| "Hypertension is a common disease that includes oxidative stress as a major feature, and oxidative stress impairs physiological nitric oxide (NO) activity promoting cardiovascular pathophysiological mechanisms." | 1.42 | Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension. ( Amaral, JH; Ferreira, GC; Montenegro, MF; Pinheiro, LC; Tanus-Santos, JE, 2015) |
| " Furthermore, a significant improvement of coronary flow and a significant reduction of endothelial dysfunction were observed in SHRs submitted to chronic administration of VA694." | 1.39 | The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and endotheli ( Anzini, M; Biava, M; Breschi, MC; Calderone, V; Cappelli, A; Caselli, G; Consalvi, S; Di Capua, A; Ghelardini, C; Giordani, A; Martelli, A; Patrignani, P; Poce, G; Rovati, L; Sautebin, L; Testai, L, 2013) |
| "To compare the circulating levels of adiponectin and nitric oxide (NO) bioavailability in eutrophic, eutrophic hypertensive, obese, and obese hypertensive children and adolescents, and to assess whether adiponectin is associated with increased NO bioavailability in these children and adolescents." | 1.39 | Adiponectin associates positively with nitrite levels in children and adolescents. ( Belo, VA; Carmo, VP; Lacchini, R; Lanna, CM; Sertório, JT; Souza-Costa, DC; Tanus-Santos, JE, 2013) |
| "Periodontitis was determined by a clinical attachment loss of >6 mm at six probe points on 12 index teeth." | 1.39 | Association between periodontitis and salivary nitric oxide metabolites among community elderly Koreans. ( Han, DH; Kim, HD; Kim, MS; Park, KP; Shin, HS, 2013) |
| "Aliskiren treatment, either concurrent or subsequent, elevated plasma NO(2) levels and reduced systolic hypertension, insulin resistance, dyslipidemia, aortic lipid peroxide levels and aortic wall hypertrophy in FHR." | 1.39 | Direct renin inhibitor prevents and ameliorates insulin resistance, aortic endothelial dysfunction and vascular remodeling in fructose-fed hypertensive rats. ( Chou, CL; Fang, TC; Lee, TJ; Pang, CY, 2013) |
| "Hypertension is a disorder affecting millions worldwide, and is a leading cause of death and debilitation in the United States." | 1.38 | Aorta from angiotensin II hypertensive mice exhibit preserved nitroxyl anion mediated relaxation responses. ( Labazi, H; Tostes, RC; Webb, RC; Wynne, BM, 2012) |
| "Uncontrolled hemorrhagic shock was induced in NT and HT rats (n=7 each) by preliminary bleed of 25 ml/kg followed by a 75% tail amputation." | 1.38 | Hemodynamic responses and serum nitrite concentration during uncontrolled hemorrhagic shock in normotensive and hypertensive rats. ( Barmaki, B; Khazaei, M; Nasimi, A, 2012) |
| "Amlodipine treatment reduced the contractions and improved relaxation to ACh." | 1.37 | Amlodipine ameliorates endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats. ( Cheng, G; He, X; Jiang, HK; Li, DL; Sun, L; Yang, JL; Yu, XJ; Zang, WJ; Zhang, HL; Zhao, M; Zhao, Q, 2011) |
| " We evaluated the antihypertensive effects of sodium nitrite given in drinking water for 4 weeks in two-kidney one-clip (2K1C) hypertensive rats and the effects induced by nitrite on NO bioavailability and oxidative stress." | 1.37 | Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension. ( Amaral, JH; Ferreira, GC; Marçal, DM; Montenegro, MF; Pereira, RP; Pinheiro, LC; Reis, RI; Sakamoto, EK; Tanus-Santos, JE, 2011) |
| " Oral administration of veratric acid at the dosage of 40 mg/kg considerably decreased systolic and diastolic blood pressure, lipid peroxidation products; increased plasma nitric oxide levels and showed no toxicity which was measured using hepatic and renal function markers when compared to other doses of veratric acid (20, 80 mg/kg)." | 1.37 | Veratric acid, a phenolic acid attenuates blood pressure and oxidative stress in L-NAME induced hypertensive rats. ( Raja, B; Saravanakumar, M, 2011) |
| "Obesity and hypertension are the two major risk factors that contribute to the progression of end-stage renal disease." | 1.36 | Obesity is the major contributor to vascular dysfunction and inflammation in high-fat diet hypertensive rats. ( Elmarakby, AA; Imig, JD, 2010) |
| " Our data suggest that the effect of the sex of the animal on NOS activity and expression is different in the three regions of the SHR kidney and supports the hypothesis that male SHR have lower NO bioavailability compared with females." | 1.36 | Renal NOS activity, expression, and localization in male and female spontaneously hypertensive rats. ( Hyndman, KA; Pardieck, JL; Pollock, JS; Sullivan, JC, 2010) |
| " Long-term administration of honokiol (400 mg/kg/d) to SHR decreased systolic blood pressure significantly." | 1.36 | Effects of chronic treatment with honokiol in spontaneously hypertensive rats. ( Luo, JD; Luo, MS; Wang, RJ; Zhang, GP; Zhang, GS; Zhang, HN, 2010) |
| "Treatment with captopril was also performed in SHR in order to compare the antioxidant and antihypertensive effects of LC and captopril." | 1.36 | Systemic antioxidant properties of L-carnitine in two different models of arterial hypertension. ( Mate, A; Miguel-Carrasco, JL; Monserrat, MT; Vázquez, CM, 2010) |
| "Melatonin treatment of IH-exposed animals decreased blood pressure, blood glucose, and ROS and nitrite/nitrate levels, and increased vasodilation and capillary perfusion." | 1.35 | Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia. ( Bertuglia, S; Reiter, RJ, 2009) |
| " We therefore studied the effect of acute and chronic administration of l-arginine (a substrate for endothelial nitric oxide synthase) on the renal hemodynamic and vascular structural alterations induced by HU." | 1.34 | Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. ( Avila-Casado, C; Franco, M; Herrera-Acosta, J; Johnson, RJ; López-Molina, R; Nakagawa, T; Nepomuceno, T; Sánchez-Lozada, LG; Soto, V; Tapia, E, 2007) |
| "The roles of nitric oxide (NO) and plasma renin activity (PRA) in the depressor response to chronic administration of Tempol in spontaneously hypertensive rats (SHR) are not clear." | 1.33 | Systemic arterial pressure response to two weeks of Tempol therapy in SHR: involvement of NO, the RAS, and oxidative stress. ( Bell, W; Cucchiarelli, VE; Fortepiani, LA; Iliescu, R; Reckelhoff, JF; Romero, D; Santacruz, F; Yanes, L; Zhang, H, 2005) |
| "Pulmonary hypertension is common in patients with chronic obstructive pulmonary disease (COPD), but the precise mechanism of vascular impairment in these patients is unknown." | 1.33 | Endothelial cell activity in chronic obstructive pulmonary disease without severe pulmonary hypertension. ( Baraldo, S; Casoni, G; Cella, G; Papi, A; Rigno, M; Saetta, M; Turato, G, 2005) |
| "Patients with ADPKD have defective nitric oxide generation from diminished cNOS activity." | 1.32 | Endothelial dysfunction and reduced nitric oxide in resistance arteries in autosomal-dominant polycystic kidney disease. ( Iversen, J; Strandgaard, S; Wang, D; Wilcox, CS, 2003) |
| "Both uncontrolled hypertension and type II diabetes mellitus, but not smoking, are associated with impaired vascular smooth-muscle reactivity induced by NO donors." | 1.32 | Uncontrolled hypertension, uncompensated type II diabetes, and smoking have different patterns of vascular dysfunction. ( Cittadino, M; Moreno, H; Sabha, M; Sousa, MG; Tácito, LH; Tanus-Santos, JE; Yugar-Toledo, JC, 2004) |
| "2." | 1.31 | Vasorelaxant effects of a nitric oxide-releasing aspirin derivative in normotensive and hypertensive rats. ( del Soldato , P; Dicay, M; Lovren, F; McKnight, W; Muscará, MN; Triggle, CR; Wallace, JL, 2001) |
| "Treatment with enalapril for 3 months lowered the mean arterial pressure from 94+/-2 to 84+/-4 mm Hg in control rats and from 146+/-3 to 89+/-3 mm Hg in TGR." | 1.30 | Enalapril and pressure-diuresis in hypertensive rats transgenic for mouse renin gene. ( Ganten, D; Springate, J; Van Liew, J, 1997) |
| "Children attending the above centre for treatment of hypertension." | 1.30 | Nitric oxide activity in childhood hypertension. ( Dillon, MJ; Goonasekera, CD; Rees, DD; Shah, V, 1997) |
| "Cyclosporin-induced hypertension is a major complication of immunosuppression in transplant recipients but its pathophysiology is only partly understood." | 1.30 | Modulation of nitric oxide improves cyclosporin A-induced hypertension in rats and primates. ( Bartholomeusz, B; Hardy, KJ; Nelson, AS; Phillips, PA, 1998) |
| "Thus, acute euglycemic hyperinsulinemia produces a decrease in plasma ET-1 in both EH patients and controls." | 1.30 | Effects of acute euglycemic hyperinsulinemia on urinary nitrite/nitrate excretion and plasma endothelin-1 levels in men with essential hypertension and normotensive controls. ( Dubiel, JS; Froelich, JC; Kokot, F; Kruszelnicka-Kwiatkowska, O; Nowicki, M; Sandmann, J; Surdacki, A; Tsikas, D, 1999) |
| "Hypertension is a side effect of systemically administered glucocorticoids, but the underlying molecular mechanism remains poorly understood." | 1.30 | Down-regulation of the expression of endothelial NO synthase is likely to contribute to glucocorticoid-mediated hypertension. ( Förstermann, U; Kleinert, H; Lehr, HA; Lemmer, B; Prellwitz, W; Schäfer, SC; Schwarz, PM; Wallerath, T; Witte, K; Wohlfart, P, 1999) |
| "Plasma from women with preeclampsia had significantly lower nitrate/nitrite concentrations and significantly higher lipid peroxide levels than normal pregnant women before the delivery." | 1.30 | Plasma nitric oxide metabolites and lipid peroxide levels in preeclamptic pregnant women before and after delivery. ( Ademoglu, E; Aykaç-Toker, G; Ibrahimoglu, L; Mutlu-Türkoglu, U; Uysal, M, 1999) |
| " The areas under the curve of the concentration responses to phenylephrine (10(-9) to 3 x 10(-6) M) in the absence and presence of NG-nitroarginine methyl ester (100 microM) showed increased basal nitric oxide bioavailability in the carotid arteries infused with AdCMVeNOS compared to the control (n = 6 for each; P = 0." | 1.30 | Gene transfer of endothelial nitric oxide synthase improves nitric oxide-dependent endothelial function in a hypertensive rat model. ( Alexander, MY; Brosnan, MJ; Devlin, AM; Dominiczak, AF; Dowell, F; Downie, P; Hamilton, CA; Martin, W; O'Brien, T; Prentice, HM, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (8.39) | 18.7374 |
| 1990's | 41 (12.73) | 18.2507 |
| 2000's | 114 (35.40) | 29.6817 |
| 2010's | 117 (36.34) | 24.3611 |
| 2020's | 23 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Park, S | 1 |
| Lee, KH | 1 |
| Choi, H | 1 |
| Jang, G | 1 |
| Kang, WS | 1 |
| Kim, E | 1 |
| Kim, JS | 2 |
| Na, CS | 1 |
| Kim, S | 1 |
| Ronchetti, GZ | 1 |
| Simões, MR | 1 |
| Schereider, IRG | 1 |
| Leal, MAS | 1 |
| Peçanha, GAW | 1 |
| Padilha, AS | 1 |
| Vassallo, DV | 2 |
| Raubenheimer, K | 1 |
| Liu, AH | 2 |
| Koch, H | 1 |
| Bosio, E | 1 |
| Bondonno, NP | 2 |
| Matthews, V | 1 |
| Sim, M | 1 |
| Blekkenhorst, L | 1 |
| Woodman, RJ | 3 |
| Murray, K | 1 |
| Croft, K | 1 |
| Neubauer, O | 1 |
| Hodgson, JM | 3 |
| Bondonno, CP | 3 |
| Srour, B | 1 |
| Chazelas, E | 1 |
| Fezeu, LK | 1 |
| Javaux, G | 1 |
| Pierre, F | 1 |
| Huybrechts, I | 1 |
| Hercberg, S | 1 |
| Deschasaux-Tanguy, M | 1 |
| Kesse-Guyot, E | 1 |
| Touvier, M | 1 |
| Benjamim, CJR | 1 |
| Sousa, YBA | 1 |
| Porto, AA | 1 |
| de Moraes Pontes, YM | 1 |
| Tavares, SS | 1 |
| da Silva Rodrigues, G | 1 |
| da Silva, LSL | 1 |
| da Silva Goncalves, L | 1 |
| Guimaraes, CS | 1 |
| Rebelo, MA | 1 |
| da Silva Sobrinho, AC | 1 |
| Tanus-Santos, JE | 17 |
| Valenti, VE | 1 |
| Gualano, B | 1 |
| Bueno Júnior, CR | 1 |
| Kotopoulou, S | 2 |
| Zampelas, A | 2 |
| Magriplis, E | 2 |
| Willmott, T | 2 |
| Ormesher, L | 1 |
| McBain, AJ | 2 |
| Humphreys, GJ | 2 |
| Myers, JE | 1 |
| Singh, G | 1 |
| Lundberg, JO | 5 |
| Weitzberg, E | 4 |
| Nihlen, C | 1 |
| Cottrell, EC | 1 |
| Gonzaga, NA | 1 |
| do Vale, GT | 1 |
| da Silva, CBP | 1 |
| Pinheiro, LC | 8 |
| Leite, LN | 1 |
| Carneiro, FS | 1 |
| Tirapelli, CR | 1 |
| Ling, WC | 2 |
| Mustafa, MR | 2 |
| Murugan, DD | 2 |
| Sundqvist, ML | 1 |
| Larsen, FJ | 1 |
| Carlström, M | 3 |
| Bottai, M | 1 |
| Pernow, J | 1 |
| Hellénius, ML | 1 |
| Sanches-Lopes, JM | 1 |
| Ferreira, GC | 5 |
| Kemp, R | 1 |
| Craig, A | 2 |
| Mels, CMC | 2 |
| Schutte, AE | 2 |
| Tsikas, D | 3 |
| Kruger, R | 2 |
| Adedapo, ADA | 1 |
| Ajayi, AM | 1 |
| Ekwunife, NL | 1 |
| Falayi, OO | 1 |
| Oyagbemi, A | 1 |
| Omobowale, TO | 1 |
| Adedapo, AA | 1 |
| Ranasinghe, HN | 1 |
| Fernando, N | 1 |
| Handunnetti, S | 1 |
| Weeratunga, PN | 1 |
| Katulanda, P | 1 |
| Rajapakse, S | 1 |
| Galappatthy, P | 1 |
| Constantine, GR | 1 |
| Bollenbach, A | 1 |
| Schwedhelm, E | 1 |
| Torrens, C | 1 |
| Feelisch, M | 2 |
| Guimaraes, DA | 2 |
| Batista, RIM | 1 |
| Myers, J | 1 |
| Cottrell, E | 1 |
| Costa, MA | 1 |
| Matsumoto, JPP | 1 |
| Carrettiero, DC | 1 |
| Fior-Chadi, DR | 1 |
| Stamm, P | 1 |
| Oelze, M | 1 |
| Steven, S | 1 |
| Kröller-Schön, S | 1 |
| Kvandova, M | 1 |
| Kalinovic, S | 1 |
| Jasztal, A | 1 |
| Kij, A | 1 |
| Kuntic, M | 1 |
| Bayo Jimenez, MT | 1 |
| Proniewski, B | 2 |
| Li, H | 2 |
| Schulz, E | 1 |
| Chlopicki, S | 2 |
| Daiber, A | 1 |
| Münzel, T | 1 |
| van der Avoort, CMT | 1 |
| Ten Haaf, DSM | 1 |
| Bongers, CCWG | 1 |
| van Oorschot, F | 1 |
| Verdijk, LB | 1 |
| van Loon, LJC | 1 |
| Hopman, MTE | 1 |
| Wang, B | 2 |
| Sheng, Y | 1 |
| Li, Y | 1 |
| Li, B | 2 |
| Zhang, J | 1 |
| Li, A | 2 |
| Liu, M | 3 |
| Zhang, H | 3 |
| Xiu, R | 2 |
| Fabricio, V | 1 |
| Oishi, JC | 1 |
| Biffe, BG | 1 |
| Ruffoni, LD | 1 |
| Silva, KA | 1 |
| Nonaka, KO | 1 |
| Rodrigues, GJ | 1 |
| Bryan, NS | 2 |
| Tribble, G | 1 |
| Angelov, N | 1 |
| Shaltout, HA | 1 |
| Eggebeen, J | 1 |
| Marsh, AP | 1 |
| Brubaker, PH | 1 |
| Laurienti, PJ | 1 |
| Burdette, JH | 1 |
| Basu, S | 1 |
| Morgan, A | 1 |
| Dos Santos, PC | 1 |
| Norris, JL | 1 |
| Morgan, TM | 1 |
| Miller, GD | 1 |
| Rejeski, WJ | 1 |
| Hawfield, AT | 1 |
| Diz, DI | 1 |
| Becton, JT | 1 |
| Kim-Shapiro, DB | 1 |
| Kitzman, DW | 1 |
| Jordão, CP | 1 |
| Fernandes, T | 2 |
| Tanaka, LY | 1 |
| Bechara, LRG | 1 |
| de Sousa, LGO | 1 |
| Oliveira, EM | 2 |
| Ramires, PR | 1 |
| Wynne, BM | 2 |
| Labazi, H | 2 |
| Tostes, RC | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Diet and Nitric Oxide (DINO): A Study on the Effects of Dietary Nitrate on Blood Pressure in Subjects With Prehypertension[NCT02916615] | 225 participants (Actual) | Interventional | 2016-01-31 | Completed | |||
| 'Oral Microbiome -Dietary Nitrate' Interactions and Cognitive Health in Older Age[NCT05518214] | 60 participants (Anticipated) | Interventional | 2021-09-29 | Recruiting | |||
| Effects of Relaxation Breathing Exercises on Cardiovascular Parameters Among Hypertensive Patients[NCT06131528] | 40 participants (Anticipated) | Interventional | 2023-10-30 | Recruiting | |||
| A Randomised, Double-blind, Placebo-controlled Study Investigating the Effects of Dietary Nitrate on Vascular Function, Platelet Reactivity and Restenosis in Stable Angina[NCT02529189] | Phase 2 | 300 participants (Anticipated) | Interventional | 2015-11-30 | Active, not recruiting | ||
| The Effects of Beetroot Bread on Postprandial Blood Pressure According to Glu298Asp Polymorphism in the eNOS Gene[NCT02037308] | 14 participants (Actual) | Interventional | 2010-06-30 | Completed | |||
| The Effects of Beetroot Enriched Bread on Postprandial Vascular Function, Arterial Stiffness and Blood Pressure in Healthy Men[NCT01706718] | 24 participants (Actual) | Interventional | 2010-06-30 | Completed | |||
| A Trial of Daily Ultraviolet Therapy to Reduce Cardiovascular Risk Factors[NCT02621866] | 13 participants (Actual) | Interventional | 2017-05-02 | Terminated (stopped due to Poor recruitment) | |||
| Investigation of Dietary Nitrate Effects in Hypertension-induced Target Organ Damage[NCT03088514] | Phase 2 | 160 participants (Anticipated) | Interventional | 2017-03-23 | Recruiting | ||
| The Chronic Effects of Beetroot Juice on Circulating Plasma Nitrate and Nitrite Levels and Blood Pressure in Hypertensive Subjects[NCT01405898] | 68 participants (Actual) | Interventional | 2010-01-31 | Completed | |||
| A Double-blind, Randomised, Placebo-controlled Parallel Study to Investigate the Influence of Dietary Nitrate on Skin Inflammation in Healthy Volunteers[NCT03183830] | Phase 1 | 24 participants (Actual) | Interventional | 2017-02-02 | Completed | ||
| Investigation of Dietary Nitrate Optimisation by Hyperuricaemia Stratification in Heart Failure[NCT03511248] | Phase 2 | 92 participants (Anticipated) | Interventional | 2018-06-01 | Active, not recruiting | ||
| Effect of Low Versus Standard Dialysate Sodium on 48h Ambulatory BP in Patients With Intradialytic Hypertension[NCT05430438] | 30 participants (Actual) | Interventional | 2022-06-01 | Completed | |||
| Effects of High-Intensity Interval Versus Moderate-Intensity Continuous Heated Water-Based Exercise on Blood Pressure and Hemodynamic Variables in Older Individuals With Hypertension[NCT04126785] | 60 participants (Anticipated) | Interventional | 2019-11-30 | Not yet recruiting | |||
| Effects of High Intensity Interval Exercise on Inflammation and Endothelial Function in Children & Adolescents With Obesity[NCT01821313] | 43 participants (Actual) | Interventional | 2012-09-30 | Completed | |||
| Decrease in Blood Pressure in PARQVE[NCT04052308] | 63 participants (Anticipated) | Interventional | 2019-10-01 | Not yet recruiting | |||
| The Effect of Moderate-Intensity Exercise on Postprandial Plasma Triglyceride Levels Following a High Fat Meal[NCT05291767] | 7 participants (Actual) | Interventional | 2022-03-28 | Terminated (stopped due to Personnel and funding issues) | |||
| Investigation of the Sex Differences in Oral Microbiota and Their Effect on Circulating Nitrite Levels[NCT01583803] | 24 participants (Anticipated) | Observational | 2012-06-30 | Active, not recruiting | |||
| The Acute Effect of Beetroot Juice on Circulating Nitrate and Nitrite Levels and Blood Pressure in Normotensives and Hypertensives[NCT01236872] | 15 participants (Actual) | Interventional | 2009-12-31 | Completed | |||
| Acute Dietary Nitrate Supplementation to Improve Performance in Endurance Trained Athletes[NCT01384968] | 20 participants (Actual) | Interventional | 2011-07-31 | Completed | |||
| The Health Effects of a Blueberry Enriched Diet on Obese Children: A Feasibility Study[NCT01809795] | 10 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
| Comparative Effects of Mild and Moderate Aerobic Exercises on Blood Pressure, Oxygen Saturation and Heart Rate in Hypertensive Patients[NCT05409456] | 28 participants (Actual) | Interventional | 2022-05-11 | Completed | |||
| Preoperative Use of Tocotrienol Associated With Personalized Nutritional and Psychoeducational Support in Women With Primary Breast Cancer.[NCT04496492] | Phase 2 | 50 participants (Actual) | Interventional | 2016-02-09 | Completed | ||
| Dietary Nitrate Supplementation and Thermoregulation During Exercise[NCT03506646] | 10 participants (Anticipated) | Interventional | 2018-09-05 | Active, not recruiting | |||
| A Pilot Study of the Effect of Dietary Sodium Intake on Assessments of Vascular Endothelium[NCT01550315] | 27 participants (Actual) | Interventional | 2012-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01405898)
Timeframe: 4 weeks
| Intervention | mmHg (Mean) |
|---|---|
| Beetroot Juice | -4.3 |
| Nitrate-free Beetroot Juice | 0.9 |
(NCT01405898)
Timeframe: 4 weeks
| Intervention | mmHg (Mean) |
|---|---|
| Beetroot Juice | -6.6 |
| Nitrate-free Beetroot Juice | 0.8 |
carotid-femoral pulse wave velocity [m/s] measured by Vicorder (NCT01405898)
Timeframe: 4 weeks
| Intervention | m/s (Mean) |
|---|---|
| Beetroot Juice | -0.59 |
| Nitrate-free Beetroot Juice | 0.01 |
(NCT01405898)
Timeframe: 4 weeks
| Intervention | mmHg (Mean) |
|---|---|
| Beetroot Juice | -3.2 |
| Nitrate-free Beetroot Juice | -0.7 |
(NCT01405898)
Timeframe: 4 weeks
| Intervention | mmHg (Mean) |
|---|---|
| Beetroot Juice | -8.7 |
| Nitrate-free Beetroot Juice | -1.0 |
as measured by flow-mediated dilatation [%change in diameter of vessel] - an increase in diameter demonstrates an improvement in endothelial function (NCT01405898)
Timeframe: 4 weeks
| Intervention | % dilatation (Mean) |
|---|---|
| Beetroot Juice | 0.9 |
| Nitrate-free Beetroot Juice | 0.1 |
(NCT01405898)
Timeframe: 4 weeks
| Intervention | umol/L (Mean) |
|---|---|
| Beetroot Juice | 0.53 |
| Nitrate-free Beetroot Juice | 0.01 |
The primary analysis will involve a non-parametric, paired, Signed Rank test of flow mediated dilation (FMD) between all subjects (POTS & control subjects) on the high sodium diet vs low sodium diet (NCT01550315)
Timeframe: FMD was assessed on the morning of day 7, after 6 days of being on either a high salt diet or a low salt diet.
| Intervention | percentage of change (Mean) |
|---|---|
| High Sodium POTS | 12.75 |
| Low Sodium Diet POTS | 11.65 |
| High Sodium Controls | 11.43 |
| Low Sodium Controls | 12.75 |
13 reviews available for nitrites and Hypertension
| Article | Year |
|---|---|
Therapeutic Implications of Nitrite in Hypertension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Endothelium, Vascular; Humans; Hypertension; Nitri | 2020 |
Nitrate and nitrite-based therapy to attenuate cardiovascular remodelling in arterial hypertension.
Topics: Animals; Antihypertensive Agents; Arteries; Heart; Humans; Hypertension; Hypertrophy, Left Ventricul | 2021 |
Does the Oral Microbiome Play a Role in Hypertensive Pregnancies?
Topics: Female; Humans; Hypertension; Infant, Newborn; Microbiota; Mouth; Nitrates; Nitric Oxide; Nitrites; | 2020 |
Oral Microbiome and Nitric Oxide: the Missing Link in the Management of Blood Pressure.
Topics: Administration, Oral; Animals; Blood Pressure; Humans; Hypertension; Microbiota; Nitrates; Nitric Ox | 2017 |
Mechanisms underlying blood pressure reduction by dietary inorganic nitrate.
Topics: Animals; Blood Pressure; Diet; Humans; Hypertension; Nitrates; Nitric Oxide; Nitrites; Signal Transd | 2018 |
Nitrite-stimulated Gastric Formation of S-nitrosothiols As An Antihypertensive Therapeutic Strategy.
Topics: Antihypertensive Agents; Biological Availability; Humans; Hydrogen-Ion Concentration; Hypertension; | 2019 |
Mechanisms impairing blood pressure responses to nitrite and nitrate.
Topics: Blood Pressure; Humans; Hypertension; Nitrates; Nitrites | 2019 |
Dietary inorganic nitrate: From villain to hero in metabolic disease?
Topics: Adipose Tissue; Biological Availability; Diabetes Mellitus, Type 2; Diet; Heart; Humans; Hypertensio | 2016 |
Inorganic nitrate and nitrite and control of blood pressure.
Topics: Animals; Blood Pressure; Cardiovascular System; Humans; Hypertension; Nitrates; Nitrites | 2011 |
Drug therapy for hypertension and ischemic heart disease.
Topics: Adrenergic beta-Agonists; Adult; Antihypertensive Agents; Arrhythmias, Cardiac; Cardiac Glycosides; | 1980 |
Nitrite plasma levels in acute and chronic coronary heart disease.
Topics: Acute Disease; Aged; Chronic Disease; Coronary Disease; Female; Humans; Hypercholesterolemia; Hypert | 1997 |
Causes of gastric and esophageal cancer. Possible approach to prevention by vitamin C.
Topics: Alcohol Drinking; Animals; Ascorbic Acid; Cerebrovascular Disorders; Colonic Neoplasms; Diet; Esopha | 1985 |
Diagnostic and therapeutic aspects of stable angina pectoris.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Carotid Sinus; Coronary Disease; Coronary Vessels; Ele | 1971 |
48 trials available for nitrites and Hypertension
| Article | Year |
|---|---|
Oxidative Stress Induced by 30 Days of Mercury Exposure Accelerates Hypertension Development in Prehypertensive Young SHRs.
Topics: Animals; Blood Pressure; Chlorides; Hypertension; Male; Mercury; Nitrates; Nitrites; Oxidative Stres | 2022 |
Increased nitrate intake from beetroot juice does not alter soluble cellular adhesion molecules and circulating inflammatory cytokines in individuals with treated hypertension: a randomised, controlled trial.
Topics: Animals; Antioxidants; Beta vulgaris; Biomarkers; Blood Pressure; Cross-Over Studies; Cytokines; Die | 2022 |
Nitrate-rich beet juice intake on cardiovascular performance in response to exercise in postmenopausal women with arterial hypertension: study protocol for a randomized controlled trial.
Topics: Beta vulgaris; Cardiovascular System; Cross-Over Studies; Dietary Supplements; Double-Blind Method; | 2023 |
A randomized clinical trial of the effects of leafy green vegetables and inorganic nitrate on blood pressure.
Topics: Aged; Blood Pressure; Diet; Female; Humans; Hypertension; Male; Middle Aged; Nitrites; Plant Leaves; | 2020 |
The impact of propranolol on nitric oxide and total antioxidant capacity in patients with resistant hypertension-evidence from the APPROPRIATE trial.
Topics: Aged; Antihypertensive Agents; Antioxidants; Blood Pressure; Blood Pressure Monitoring, Ambulatory; | 2020 |
Increasing Nitrate-Rich Vegetable Intake Lowers Ambulatory Blood Pressure in (pre)Hypertensive Middle-Aged and Older Adults: A 12-Wk Randomized Controlled Trial.
Topics: Aged; Beta vulgaris; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Dietary Supplements; Hum | 2021 |
Dietary nitrate lowers ambulatory blood pressure in treated, uncontrolled hypertension: a 7-d, double-blind, randomised, placebo-controlled, cross-over trial.
Topics: Aged; Alanine Transaminase; Alkaline Phosphatase; Antihypertensive Agents; Bilirubin; Blood Pressure | 2018 |
Nitrate-rich vegetables do not lower blood pressure in individuals with mildly elevated blood pressure: a 4-wk randomized controlled crossover trial.
Topics: Aged; Blood Pressure; Cross-Over Studies; Female; Humans; Hypertension; Male; Middle Aged; Nitrates; | 2018 |
Impact of Acute Dietary Nitrate Supplementation during Exercise in Hypertensive Women.
Topics: Beta vulgaris; Blood Pressure; Brachial Artery; Cross-Over Studies; Dietary Supplements; Double-Blin | 2019 |
A Single Dose of Beetroot Juice Does Not Change Blood Pressure Response Mediated by Acute Aerobic Exercise in Hypertensive Postmenopausal Women.
Topics: Beta vulgaris; Beverages; Blood Pressure; Cross-Over Studies; Double-Blind Method; Exercise; Exercis | 2019 |
Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential.
Topics: Allopurinol; Animals; Blood Pressure; Cross-Over Studies; Disease Models, Animal; Dose-Response Rela | 2013 |
Acute ingestion of beetroot bread increases endothelium-independent vasodilation and lowers diastolic blood pressure in healthy men: a randomized controlled trial.
Topics: Adult; Beta vulgaris; Blood Pressure; Body Mass Index; Bread; Cross-Over Studies; Diet; Endothelium; | 2013 |
Acute ingestion of beetroot bread increases endothelium-independent vasodilation and lowers diastolic blood pressure in healthy men: a randomized controlled trial.
Topics: Adult; Beta vulgaris; Blood Pressure; Body Mass Index; Bread; Cross-Over Studies; Diet; Endothelium; | 2013 |
Acute ingestion of beetroot bread increases endothelium-independent vasodilation and lowers diastolic blood pressure in healthy men: a randomized controlled trial.
Topics: Adult; Beta vulgaris; Blood Pressure; Body Mass Index; Bread; Cross-Over Studies; Diet; Endothelium; | 2013 |
Acute ingestion of beetroot bread increases endothelium-independent vasodilation and lowers diastolic blood pressure in healthy men: a randomized controlled trial.
Topics: Adult; Beta vulgaris; Blood Pressure; Body Mass Index; Bread; Cross-Over Studies; Diet; Endothelium; | 2013 |
Acute cardiac and hemodynamic effects of sildenafil on resistant hypertension.
Topics: Aged; Arterial Pressure; Cross-Over Studies; Cyclic GMP; Drug Resistance; Female; Genotype; Hemodyna | 2013 |
Tadalafil-induced improvement in left ventricular diastolic function in resistant hypertension.
Topics: Aged; Blood Pressure; Carbolines; Cross-Over Studies; Cyclic GMP; Diastole; Drug Resistance; Female; | 2014 |
UVA irradiation of human skin vasodilates arterial vasculature and lowers blood pressure independently of nitric oxide synthase.
Topics: Blood Pressure; Computer Simulation; Epidermis; Female; Forearm; Healthy Volunteers; Humans; Hyperte | 2014 |
Chia flour supplementation reduces blood pressure in hypertensive subjects.
Topics: Adult; Biomarkers; Blood Pressure; Dietary Supplements; Female; Flour; Humans; Hypertension; Lipid P | 2014 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Beta vulgaris; Beverages; Biotransformation; Blood Press | 2015 |
A session of resistance exercise increases vasodilation in intermittent claudication patients.
Topics: Aged; Endothelium, Vascular; Female; Humans; Hyperemia; Hypertension; Intermittent Claudication; Leg | 2015 |
Effect of low versus high dialysate sodium concentration on blood pressure and endothelial-derived vasoregulators during hemodialysis: a randomized crossover study.
Topics: Aged; Blood Pressure; Cross-Over Studies; Dialysis Solutions; Endothelin-1; Endothelium, Vascular; F | 2015 |
High-nitrate vegetable diet increases plasma nitrate and nitrite concentrations and reduces blood pressure in healthy women.
Topics: Adolescent; Adult; Blood Pressure; Cross-Over Studies; Diet; Feeding Behavior; Female; Humans; Hyper | 2015 |
The role of sustained release isosorbide mononitrate on corticosteroid-induced hypertension in healthy human subjects.
Topics: Adult; Anti-Inflammatory Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Body Weight; | 2015 |
Absence of an effect of high nitrate intake from beetroot juice on blood pressure in treated hypertensive individuals: a randomized controlled trial.
Topics: Aged; Antihypertensive Agents; Beta vulgaris; Beverages; Combined Modality Therapy; Cross-Over Studi | 2015 |
Combined exercise reduces arterial stiffness, blood pressure, and blood markers for cardiovascular risk in postmenopausal women with hypertension.
Topics: Aged; Aged, 80 and over; Ankle Brachial Index; Biomarkers; Blood Pressure; Body Composition; Cardiov | 2017 |
Effect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women.
Topics: Blood Pressure; Body Mass Index; Cholesterol; Exercise Therapy; Female; Heart Rate; Humans; Hyperten | 2009 |
Women with TT genotype for eNOS gene are more responsive in lowering blood pressure in response to exercise.
Topics: 5' Flanking Region; Blood Pressure; Double-Blind Method; Exercise Therapy; Female; Genotype; Humans; | 2010 |
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension.
Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener | 2010 |
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension.
Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener | 2010 |
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension.
Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener | 2010 |
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension.
Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener | 2010 |
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension.
Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener | 2010 |
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension.
Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener | 2010 |
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension.
Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener | 2010 |
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension.
Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener | 2010 |
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension.
Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener | 2010 |
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension.
Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener | 2010 |
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension.
Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener | 2010 |
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension.
Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener | 2010 |
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension.
Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener | 2010 |
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension.
Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener | 2010 |
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension.
Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener | 2010 |
Effects of high-intensity aerobic interval training vs. moderate exercise on hemodynamic, metabolic and neuro-humoral abnormalities of young normotensive women at high familial risk for hypertension.
Topics: Adult; Blood Flow Velocity; Blood Glucose; Blood Pressure; Endothelin-1; Endothelium, Vascular; Ener | 2010 |
Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.
Topics: Blood Pressure; Brachial Artery; Cardiovascular Diseases; Cross-Over Studies; Cyclic GMP; Double-Bli | 2010 |
Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.
Topics: Blood Pressure; Brachial Artery; Cardiovascular Diseases; Cross-Over Studies; Cyclic GMP; Double-Bli | 2010 |
Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.
Topics: Blood Pressure; Brachial Artery; Cardiovascular Diseases; Cross-Over Studies; Cyclic GMP; Double-Bli | 2010 |
Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.
Topics: Blood Pressure; Brachial Artery; Cardiovascular Diseases; Cross-Over Studies; Cyclic GMP; Double-Bli | 2010 |
Antihypertensive effects exerted by enalapril in mild to moderate hypertension are not associated with changes in the circulating levels of nitric oxide-related markers.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Biomarkers, Pharmacological; Blood Pressure; Dinopr | 2011 |
Impacts of lisinopril and lisinopril plus simvastatin on erythrocyte and plasma arginase, nitrite, and nitrate in hypertensive patients.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arginase; Atheroscle | 2012 |
Effects of ACE inhibition on circulating endothelial progenitor cells, vascular damage, and oxidative stress in hypertensive patients.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Captopril; Carotid Arteries; Cell Count; Cell Movem | 2011 |
All-natural nitrite and nitrate containing dietary supplement promotes nitric oxide production and reduces triglycerides in humans.
Topics: Adult; Aged; Beta vulgaris; Biomarkers; Dietary Supplements; Double-Blind Method; Female; Fruit; Hum | 2011 |
Vascular effects of nebivolol added to hydrochlorothiazide in African Americans with hypertension and echocardiographic evidence of diastolic dysfunction: the NASAA study.
Topics: Adult; Aged; Antihypertensive Agents; Arginine; Benzopyrans; Black or African American; Dose-Respons | 2012 |
Acute, quercetin-induced reductions in blood pressure in hypertensive individuals are not secondary to lower plasma angiotensin-converting enzyme activity or endothelin-1: nitric oxide.
Topics: Adult; Arterial Pressure; Brachial Artery; Cross-Over Studies; Double-Blind Method; Endothelin-1; Hu | 2012 |
Relationship between salt intake, nitric oxide and asymmetric dimethylarginine and its relevance to patients with end-stage renal disease.
Topics: Arginine; Blood Pressure; Cardiovascular Diseases; Female; Humans; Hypertension; Kidney Failure, Chr | 2002 |
Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Arginine; Captopril; Enalapril; Female; Humans; Hypertensi | 2004 |
Effect of doxazosin on C-reactive protein plasma levels and on nitric oxide in patients with hypertension.
Topics: Adult; Antihypertensive Agents; Biomarkers; Blood Pressure; C-Reactive Protein; Doxazosin; Female; H | 2006 |
Effects of perindopril and hydrochlorothiazide on selected indices of oxidative stress in the blood of elderly patients with essential hypertension.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Catalase; Diuretics; Drug The | 2006 |
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite.
Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H | 2008 |
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite.
Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H | 2008 |
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite.
Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H | 2008 |
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite.
Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H | 2008 |
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite.
Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H | 2008 |
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite.
Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H | 2008 |
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite.
Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H | 2008 |
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite.
Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H | 2008 |
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite.
Topics: Adolescent; Adult; Beta vulgaris; Blood Pressure; Cross-Over Studies; Diet; Endothelium, Vascular; H | 2008 |
Combination oral antioxidant supplementation reduces blood pressure.
Topics: Administration, Oral; Adult; Aged; Antioxidants; Ascorbic Acid; beta Carotene; Blood Pressure; Cross | 1997 |
Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension.
Topics: Adult; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Arginine | 1998 |
Effect of N-dicyclopropylmethyl-amino-2-oxazoline (S-3341) on antioxidant status and nitric oxide in hypertensive patients.
Topics: Adult; Aged; Antihypertensive Agents; Antioxidants; Blood Pressure; Catalase; Humans; Hypertension; | 1998 |
Long-term effect of antihypertensive therapy with calcium antagonist or angiotensin converting enzyme inhibitor on serum nitrite/nitrate levels in human essential hypertension.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Bloc | 2000 |
Additive effects of Simvastatin beyond its effects on LDL cholesterol in hypertensive type 2 diabetic patients.
Topics: Albuminuria; Anticholesteremic Agents; Apolipoproteins; Blood Pressure; Cholesterol, LDL; Cholestyra | 2000 |
Early alteration in glomerular reserve in humans at genetic risk of essential hypertension: mechanisms and consequences.
Topics: Adult; Amino Acids; Arginine; Cyclic GMP; Female; Genetic Markers; Glomerular Filtration Rate; Human | 2001 |
Effect of salt intake on endothelium-derived factors in a group of patients with essential hypertension.
Topics: Adult; Aged; Aldosterone; Angiotensin II; Atrial Natriuretic Factor; Blood Pressure Monitoring, Ambu | 2001 |
Paradoxical decrease in plasma NOx by L-arginine load in diabetic and non-diabetic subjects.
Topics: Arginine; Blood Glucose; Blood Pressure; Cyclic GMP; Diabetes Mellitus, Type 2; Endothelium, Vascula | 2002 |
Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by noninvasive evaluation.
Topics: Adrenergic alpha-Antagonists; Aorta; Arteriosclerosis; Doxazosin; Elasticity; Endothelium, Vascular; | 2002 |
[Treatment of essential hypertension with a combination of chlorothiazide and etrynit].
Topics: Chlorothiazide; Clinical Trials as Topic; Humans; Hypertension; Nitrites | 1965 |
261 other studies available for nitrites and Hypertension
| Article | Year |
|---|---|
Combined antihypertensive effect of unripe Rubus coreanus Miq. and Dendropanax morbiferus H. Lév. Extracts in 1 kidney-1 clip hypertensive rats and spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Drug Therapy, Combination; | 2021 |
Nitrites, Nitrates, and Cardiovascular Outcomes: Are We Living "La Vie en Rose" With Pink Processed Meats?
Topics: Adult; Cardiovascular Diseases; Diet; Food Additives; Humans; Hypertension; Meat; Nitrates; Nitrites | 2022 |
Nitrite and nitrate intake from processed meat is associated with elevated diastolic blood pressure (DBP).
Topics: Adult; Blood Pressure; Female; Humans; Hypertension; Male; Meat; Nitrates; Nitrites; Sodium; Sodium, | 2023 |
Reply-letter to the editor: "Nitrite and nitrate intake from processed meat is associated with elevated diastolic blood pressure (DBP)".
Topics: Blood Pressure; Diet; Humans; Hypertension; Meat; Nitrates; Nitrites; Organic Chemicals | 2023 |
Altered Oral Nitrate Reduction and Bacterial Profiles in Hypertensive Women Predict Blood Pressure Lowering Following Acute Dietary Nitrate Supplementation.
Topics: Adult; Bacteria; Beta vulgaris; Blood Pressure; Dietary Supplements; Female; Humans; Hypertension; N | 2023 |
Treatment with nitrite prevents reactive oxygen species generation in the corpora cavernosa and restores intracavernosal pressure in hypertensive rats.
Topics: Animals; Antihypertensive Agents; Antioxidants; Erectile Dysfunction; Hypertension; Male; Nitrites; | 2020 |
Consistent gastric pH-dependent effects of suppressors of gastric acid secretion on the antihypertensive responses to oral nitrite.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Gast | 2020 |
Nitric oxide-related markers link inversely to blood pressure in black boys and men: the ASOS and African-PREDICT studies.
Topics: Adult; Biomarkers; Black People; Blood Pressure; Carotid Intima-Media Thickness; Child; Humans; Hype | 2020 |
Antihypertensive effect of Phragmanthera incana (Schum) Balle on NG-nitro-L-Arginine methyl ester (L-NAME) induced hypertensive rats.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Arterial Pressure; Biomark | 2020 |
Urinary albumin-to-creatinine ratio is inversely related to nitric oxide synthesis in young black adults: the African-PREDICT study.
Topics: Adult; Albumins; Arginine; Biomarkers; Creatinine; Homoarginine; Humans; Hypertension; Nitrates; Nit | 2021 |
How to beet hypertension in pregnancy: is there more to beetroot juice than nitrate?
Topics: Animals; Beta vulgaris; Blood Pressure; Female; Hypertension; Mice; Nitrates; Nitrites; Pregnancy | 2020 |
Adenosine A
Topics: Adenosine; Animals; Cells, Cultured; Female; Hypertension; Male; Medulla Oblongata; Nitric Oxide; Ni | 2020 |
Direct comparison of inorganic nitrite and nitrate on vascular dysfunction and oxidative damage in experimental arterial hypertension.
Topics: Administration, Oral; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Hypertension | 2021 |
Lymphatic microcirculation profile in the progression of hypertension in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Endothelin-1; Hypertension; Lymphatic Vessels; Microcirculation; Nitrates; | 2022 |
Resveratrol Treatment Normalizes the Endothelial Function and Blood Pressure in Ovariectomized Rats.
Topics: Animals; Antioxidants; Blood Pressure; Endothelium, Vascular; Estrogens; Female; Hypertension; Nitra | 2017 |
Effects of supervised exercise and dietary nitrate in older adults with controlled hypertension and/or heart failure with preserved ejection fraction.
Topics: Aged; Beta vulgaris; Blood Pressure; Dietary Supplements; Exercise; Female; Fruit and Vegetable Juic | 2017 |
Aerobic Swim Training Restores Aortic Endothelial Function by Decreasing Superoxide Levels in Spontaneously Hypertensive Rats.
Topics: Animals; Aorta, Thoracic; Blotting, Western; Endothelium, Vascular; Ethidium; Exercise Test; Fluores | 2017 |
Nitroxyl Anion Mediates Relaxation in Mesenteric Arteries from Angiotensin II Hypertensive Mice.
Topics: 4-Aminopyridine; Acetylcholine; Angiotensin II; Animals; Disease Models, Animal; Hypertension; Male; | 2017 |
Protective effect of the standardized extract of ginkgo biloba (EGb761) against hypertension with hypercholesterolemia-induced renal injury in rats: Insights in the underlying mechanisms.
Topics: Animals; Blood Pressure; Creatinine; Diastole; Ginkgo biloba; Glutathione; Hypercholesterolemia; Hyp | 2017 |
Estradiol decreases blood pressure in association with redox regulation in preeclampsia.
Topics: Adult; Arterial Pressure; Biomarkers; Estradiol; Estrogens; Female; Humans; Hydrogen Peroxide; Hyper | 2018 |
Functional status of microvascular vasomotion is impaired in spontaneously hypertensive rat.
Topics: Animals; Arginine; Blood Glucose; Blood Pressure; Cell Movement; Dimerization; Endothelial Cells; Gl | 2017 |
Contrasting effects of low versus high ascorbate doses on blood pressure responses to oral nitrite in L-NAME-induced hypertension.
Topics: Administration, Oral; Animals; Ascorbic Acid; Blood Pressure; Hypertension; Male; NG-Nitroarginine M | 2018 |
Nitrite exerts antioxidant effects, inhibits the mTOR pathway and reverses hypertension-induced cardiac hypertrophy.
Topics: Animals; Antioxidants; Cardiomegaly; Hypertension; Male; Nitrites; Oxidative Stress; Rats; Rats, Wis | 2018 |
Linalyl acetate prevents olmesartan-induced intestinal hypermotility mediated by interference of the sympathetic inhibitory pathway in hypertensive rat.
Topics: Animals; Blood Pressure; Body Weight; Cell Size; Epithelial Cells; Gastrointestinal Motility; Heart | 2018 |
Relationship Between Erectile Dysfunction, Diabetes and Dyslipidemia in Hypertensive-Treated Men.
Topics: Age Factors; Comorbidity; Diabetes Mellitus; Dyslipidemias; Erectile Dysfunction; Humans; Hypertensi | 2018 |
Effects of citrus leaf extract on aortic vascular reactivity in hypertensive rats fed repeatedly heated vegetable oil.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Citrus; Cooking; Disease Models, Animal; Ho | 2019 |
The Acute Effects of Mat Pilates on Hemodynamic and Salivary Nitrite Responses After Exercise in Postmenopausal Women.
Topics: Aged; Blood Pressure; Blood Pressure Determination; Exercise; Exercise Therapy; Female; Heart Rate; | 2019 |
[Magnetic-laser influence on the system of nitric oxide and contractile activity of smooth muscles of rat aorta under hypertension].
Topics: Acetylcholine; Animals; Aorta; Erythrocytes; Hemoglobins; Hemolysis; Hypertension; Lasers; Low-Level | 2012 |
The effect of alpha-lipoic acid on mitochondrial superoxide and glucocorticoid-induced hypertension.
Topics: Adrenocorticotropic Hormone; Animals; Antioxidants; Blood Pressure; Dexamethasone; F2-Isoprostanes; | 2013 |
Circulating blood endothelial nitric oxide synthase contributes to the regulation of systemic blood pressure and nitrite homeostasis.
Topics: Animals; Arginine; Blood Pressure; Carbon Radioisotopes; Citrulline; Endothelium, Vascular; Enzyme I | 2013 |
Nitric oxide metabolites (nitrite and nitrate) in several clinical condition.
Topics: Adult; Cardiovascular Diseases; Case-Control Studies; Diabetes Mellitus; Female; Humans; Hypertensio | 2014 |
The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and endotheli
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Coronary Vessels; Cyclooxygenase 2 | 2013 |
Effects of 1,8-cineole on hypertension induced by chronic exposure to nicotine in rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cyclohexanols; Eucalyptol; Eucalyptus; Hypertensio | 2014 |
Progesterone supplementation attenuates hypertension and the autoantibody to the angiotensin II type I receptor in response to elevated interleukin-6 during pregnancy.
Topics: 17-alpha-Hydroxyprogesterone; Animals; Autoantibodies; Female; Hypertension; Interleukin-6; Nitrates | 2014 |
L-arginine catabolism is driven mainly towards nitric oxide synthesis in the erythrocytes of patients with type 2 diabetes at first clinical onset.
Topics: Arginase; Arginine; Case-Control Studies; Diabetes Mellitus, Type 2; Electrophoresis, Capillary; Ery | 2015 |
Chronic arterial hypertension.
Topics: Arteriosclerosis; Diagnosis, Differential; History, 20th Century; Humans; Hypertension; Nitrites; Ni | 2014 |
Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Cellulase; Diet, Mediterranean; Disease Model | 2014 |
The effects of endothelial nitric oxide synthase tagSNPs on nitrite levels and risk of hypertension and obesity in children and adolescents.
Topics: Adolescent; Case-Control Studies; Child; Female; Haplotypes; Humans; Hypertension; Male; Nitric Oxid | 2015 |
Increased aortic stiffness elevates pulse and mean pressure and compromises endothelial function in Wistar rats.
Topics: Animals; Aorta; Arterial Pressure; Cytochrome P-450 Enzyme System; Disease Models, Animal; Dose-Resp | 2014 |
[Adaptative resources of the main regulatory systems in patients with hypertension under the highland conditions].
Topics: Adaptation, Physiological; Altitude; Blood Pressure; Case-Control Studies; Electrocardiography; Fema | 2014 |
Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension.
Topics: Animals; Antioxidants; Arginine; Biomarkers; Blood Pressure; Blood Vessels; Desoxycorticosterone Ace | 2015 |
Metalloproteinase Inhibition Protects against Reductions in Circulating Adrenomedullin during Lead-induced Acute Hypertension.
Topics: Adrenomedullin; Animals; Antioxidants; Blood Pressure; Calcitonin Gene-Related Peptide; Doxycycline; | 2015 |
Nitrate, nitrite, and nitric oxide find a home in the kidney by offsetting angiotensin II-mediated hypertension.
Topics: Animals; Blood Pressure; Hypertension; Kidney; Male; Microvessels; NADPH Oxidases; Nitrates; Nitrite | 2015 |
NADPH oxidase in the renal microvasculature is a primary target for blood pressure-lowering effects by inorganic nitrate and nitrite.
Topics: Animals; Blood Pressure; Disease Models, Animal; Hypertension; Kidney; Male; Mice; Mice, Inbred C57B | 2015 |
Serum nitrate and nitrite levels in patients with hypertension and ischemic stroke depend on diet: a multicenter study.
Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Diet; Female; Humans; Hypertension; Male; Middle Age | 2015 |
Pulmonary arterial hypertension in rats due to age-related arginase activation in intermittent hypoxia.
Topics: Aging; Animals; Arginase; Cell Hypoxia; Enzyme Activation; Hypertension; Lung; Male; Nitrates; Nitri | 2015 |
Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Desoxycorticosterone; Dinoprost; Dis | 2015 |
Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47phox Expression in Rats.
Topics: Animals; Blood Pressure; Ellagic Acid; Heart Rate; Hypertension; Male; Malondialdehyde; NADPH Oxidas | 2015 |
Asiatic acid alleviates cardiovascular remodelling in rats with L-NAME-induced hypertension.
Topics: Animals; Antihypertensive Agents; Aorta; Biomarkers; Blood Pressure; Collagen; Disease Models, Anima | 2015 |
The relationship between hypertension and plasma allantoin, uric acid, xanthine oxidase activity and nitrite, and their predictive capacity in severe preeclampsia.
Topics: Adult; Allantoin; Arterial Pressure; Case-Control Studies; Female; Humans; Hypertension; Nitrites; P | 2016 |
Role of xanthine oxidoreductase in the anti-thrombotic effects of nitrite in rats in vivo.
Topics: Animals; Biomarkers; Blood Coagulation; Blood Platelets; Blood Pressure; Disease Models, Animal; Fib | 2016 |
Effect of plasma NOx values on cardiac function in obese hypertensive and normotensive pediatric patients.
Topics: Adolescent; Biomarkers; Blood Pressure Monitoring, Ambulatory; Case-Control Studies; Echocardiograph | 2016 |
[FEATURES MANIFESTATIONS COMORBID CURRENTS OF GASTROESOPHAGEAL REFLUX DISEASE AND ARTERIAL HYPERTENSION DEPENDING ON THE DEGREE OF ARTERIAL HYPERTENSION].
Topics: Apelin; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Case-Control Studies; Circadian Rhyth | 2015 |
Potent antihypertensive effect of Hancornia speciosa leaves extract.
Topics: Animals; Antihypertensive Agents; Apocynaceae; Blood Pressure; Brazil; Desoxycorticosterone; Hydroge | 2016 |
The Association of Dietary l-Arginine Intake and Serum Nitric Oxide Metabolites in Adults: A Population-Based Study.
Topics: Adult; Age Factors; Arginine; Biomarkers; Body Mass Index; Chi-Square Distribution; Cross-Sectional | 2016 |
Impact of chronic administration of anabolic androgenic steroids and taurine on blood pressure in rats.
Topics: Anabolic Agents; Animals; Blood Pressure; Hypertension; Male; Nandrolone; Nandrolone Decanoate; Nitr | 2016 |
Effects of Dietary l-Arginine on Nitric Oxide Bioavailability in Obese Normotensive and Obese Hypertensive Subjects.
Topics: Arginase; Arginine; Biological Availability; Blood Pressure; Calcium Channels; Clinical Trials as To | 2016 |
Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular Dysfunction.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Cyclic GMP; Disease Models, Animal; Dose-Resp | 2016 |
Effect of nitric oxide deficiency on the pulmonary PTHrP system.
Topics: Animals; Hypertension; Lung; Lung Diseases; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; | 2017 |
Sodium nitrite exerts an antihypertensive effect and improves endothelial function through activation of eNOS in the SHR.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Aorta; Arterial Pressure; Cyclic GMP; Endothelium, | 2016 |
ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH CHRONIC OBSRTRUCTIVE PULMONARY DISEASE WITH CONCOMITANT HYPERTENSION.
Topics: Adult; Case-Control Studies; Endothelium, Vascular; Female; Humans; Hypertension; Lung Diseases, Obs | 2016 |
Oral nitrite circumvents antiseptic mouthwash-induced disruption of enterosalivary circuit of nitrate and promotes nitrosation and blood pressure lowering effect.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Hypertension; Male; Mouthw | 2016 |
Diuretic, natriuretic and potassium-sparing effect of nothofagin isolated from Leandra dasytricha (A. Gray) Cogn. leaves in normotensive and hypertensive rats.
Topics: Animals; Antioxidants; Cell Line; Chalcones; Diuretics, Potassium Sparing; Hydrochlorothiazide; Hype | 2017 |
Unusual reaction to amyl nitrite as a sigh of tight mitral stenosis; relation of mitral stenosis to hypertension.
Topics: Amyl Nitrite; Blood Pressure; Blood Pressure Determination; Constriction, Pathologic; Humans; Hypert | 1947 |
Plasma des-acyl ghrelin, but not plasma HMW adiponectin, is a useful cardiometabolic marker for predicting atherosclerosis in elderly hypertensive patients.
Topics: Adiponectin; Age Factors; Aged; Aged, 80 and over; Biomarkers; Blood Glucose; C-Reactive Protein; Ca | 2009 |
Endothelial dysfunction in patients with noncomplicated and complicated hypertension.
Topics: Aged; Atherosclerosis; Case-Control Studies; Coronary Artery Disease; Cyclic GMP; Endothelin-1; Endo | 2009 |
Role of oxidative stress in elevated blood pressure induced by high free fatty acids.
Topics: Animals; Blood Pressure; Fatty Acids, Nonesterified; Glucose Clamp Technique; Glutathione; Hypertens | 2009 |
Diets containing blueberry extract lower blood pressure in spontaneously hypertensive stroke-prone rats.
Topics: Animals; Antioxidants; Blood Pressure; Blueberry Plants; Creatinine; Diet; F2-Isoprostanes; Fruit; H | 2009 |
Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia.
Topics: Analysis of Variance; Animals; Blood Glucose; Cricetinae; Glucose Clamp Technique; Hemodynamics; Hyp | 2009 |
Low level and sub-chronic exposure to methylmercury induces hypertension in rats: nitric oxide depletion and oxidative damage as possible mechanisms.
Topics: Animals; Antioxidants; Blood Pressure; Catalase; Erythrocytes; Glutathione; Hypertension; Male; Malo | 2009 |
Association of renal damage and oxidative stress in a rat model of metabolic syndrome. Influence of gender.
Topics: Animals; Catalase; Estradiol; Estrogen Replacement Therapy; Estrogens; Female; Hormone Replacement T | 2009 |
Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice.
Topics: Angiotensin II; Animals; Bilirubin; Blood Pressure; Cardiomegaly; Disease Models, Animal; Glucuronos | 2009 |
Obesity is the major contributor to vascular dysfunction and inflammation in high-fat diet hypertensive rats.
Topics: Acetylcholine; Angiotensin II; Animals; Blood Glucose; Blood Pressure; Cyclooxygenase 2; Dietary Fat | 2010 |
Renal NOS activity, expression, and localization in male and female spontaneously hypertensive rats.
Topics: Animals; Cyclic GMP; Disease Models, Animal; Female; Hypertension; Kidney Cortex; Kidney Medulla; Ma | 2010 |
Endothelin-1, big endothelin-1, and nitric oxide in patients with chronic renal disease and hypertension.
Topics: Adult; Endothelin-1; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; Nitra | 2009 |
Refractory blood pressure in female SHR to increased oxidative stress is not mediated by NO or by upregulation of renal antioxidant enzymes.
Topics: Animals; Antioxidants; Blood Pressure; Female; Hypertension; Isoprostanes; Kidney; Male; Molsidomine | 2010 |
Upregulation of arginase expression and activity in hypertensive rats exposed to chronic intermittent hypobaric hypoxia.
Topics: Acclimatization; Altitude; Animals; Arginase; Atmospheric Pressure; Blood Pressure; Body Weight; Hea | 2009 |
Improvement of impaired endothelial function by tetrahydrobiopterin in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Biopterins; Dietary Supplements; Endothelium, Vascular; | 2010 |
Effects of chronic treatment with honokiol in spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Antioxidants; Aorta; Biphenyl Compounds; Blood Pres | 2010 |
Comparative study of potential endothelioprotectors and impaza in modeled nitric oxide deficiency.
Topics: Animals; Antibodies; Antihypertensive Agents; Antioxidants; Endothelium, Vascular; Hypertension; Mal | 2009 |
Systemic antioxidant properties of L-carnitine in two different models of arterial hypertension.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Captopril; Carnitine; Glutathione; G | 2010 |
Contrasting effects of intervention with ETA and ETB receptor antagonists in hypertension induced by angiotensin II and high-salt diet.
Topics: Acute Kidney Injury; Angiotensin II; Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; E | 2010 |
Renal function and vasomotor activity in mice lacking the Cyp4a14 gene.
Topics: Animals; Blood Pressure; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Enzyme Inhibitors | 2010 |
Mesenteric vascular remodeling in hyperhomocysteinemia.
Topics: Abdominal Pain; Amidohydrolases; Animals; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blo | 2011 |
Nitric oxide modulates reactivity to angiotensin II in internal mammary arterial grafts in hypertensive patients without associated risk factors.
Topics: Aged; Angiotensin II; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Humans; Hyper | 2011 |
Taurine prevents hypertension and increases exercise capacity in rats with fructose-induced hypertension.
Topics: Animals; Blood Glucose; Creatine Kinase; Electrolytes; Fructose; Glutathione; Hypertension; Insulin; | 2011 |
Amlodipine ameliorates endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats.
Topics: Acetylcholine; Amlodipine; Animals; Antihypertensive Agents; Ascorbic Acid; Blood Pressure; Endothel | 2011 |
Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Dinoprost; Down-Regulation; Hyperten | 2011 |
Raloxifene reduces blood pressure in hypertensive animals after ovarian hormone deprivation.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Diuresis; Drug Evaluation, Preclinical; Female; Hy | 2011 |
Association between serum nitric oxide metabolites and hypertension in a general population.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antihypertensive Agents; Blood Pressure; Chi-S | 2011 |
Aorta from angiotensin II hypertensive mice exhibit preserved nitroxyl anion mediated relaxation responses.
Topics: Acetylcholine; Angiotensin II; Animals; Aorta; Blood Pressure; Disease Models, Animal; Dose-Response | 2012 |
Aromatic C-nitrosation of a bioactive molecule. Nitrosation of minoxidil.
Topics: Alopecia; Animals; Antihypertensive Agents; Chromatography, Liquid; Dimethylnitrosamine; Drug-Relate | 2011 |
Veratric acid, a phenolic acid attenuates blood pressure and oxidative stress in L-NAME induced hypertensive rats.
Topics: Animals; Antioxidants; Biomarkers; Blood Pressure; Hypertension; Kidney; Lipid Peroxidation; Liver; | 2011 |
Large BP-dependent and -independent differences in susceptibility to nephropathy after nitric oxide inhibition in Sprague-Dawley rats from two major suppliers.
Topics: Animals; Blood Pressure; Hypertension; Kidney Diseases; Kidney Glomerulus; Male; Nephrectomy; NG-Nit | 2012 |
A blueberry-enriched diet attenuates nephropathy in a rat model of hypertension via reduction in oxidative stress.
Topics: Animals; Antioxidants; Blueberry Plants; Body Weight; Catalase; Creatinine; Diet; Glutathione; Horme | 2011 |
Oleanolic acid prevents glucocorticoid-induced hypertension in rats.
Topics: Animals; Blood Pressure; Body Weight; Dexamethasone; Glucocorticoids; Heart; Hypertension; Lipid Per | 2011 |
Astaxanthin inhibits thrombosis in cerebral vessels of stroke-prone spontaneously hypertensive rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antihypertensive Agents; Antioxidants; Cardiovascular Diseases | 2011 |
The epistasis between vascular homeostasis genes is apparent in essential hypertension.
Topics: Adult; Aldosterone; Analysis of Variance; Blood Pressure; Case-Control Studies; Chi-Square Distribut | 2012 |
The higher exercise intensity and the presence of allele I of ACE gene elicit a higher post-exercise blood pressure reduction and nitric oxide release in elderly women: an experimental study.
Topics: Aged; Alleles; Blood Pressure; Exercise; Exercise Test; Female; Genotype; Humans; Hypertension; Midd | 2011 |
Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta; Ascorbic Acid; Blood Pressure; Body Weight; Desoxycorticost | 2012 |
Thiazolidinedione treatment decreases oxidative stress in spontaneously hypertensive heart failure rats through attenuation of inducible nitric oxide synthase-mediated lipid radical formation.
Topics: Aldehydes; Animals; Body Composition; Free Radicals; Glucose Intolerance; Heart Failure; Hypertensio | 2012 |
Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat.
Topics: Animals; Biopterins; Blood Pressure; Female; Gene Expression Regulation; Hypertension; Inflammation; | 2012 |
Morin attenuates blood pressure and oxidative stress in deoxycorticosterone acetate-salt hypertensive rats: a biochemical and histopathological evaluation.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Catalase; Desoxycorticosterone; Drin | 2012 |
Hemodynamic responses and serum nitrite concentration during uncontrolled hemorrhagic shock in normotensive and hypertensive rats.
Topics: Animals; Arterial Pressure; Heart Rate; Hypertension; Male; Nitrites; Rats; Rats, Wistar; Resuscitat | 2012 |
Effect of phosphatidylinositol 3-kinase-γ inhibitor CAY10505 in hypertension, and its associated vascular endothelium dysfunction in rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Atorvastatin; Blood Pressure; Desoxycorticosterone; Endothe | 2012 |
Adiponectin associates positively with nitrite levels in children and adolescents.
Topics: Adiponectin; Adolescent; Analysis of Variance; Biological Availability; Biomarkers; Body Mass Index; | 2013 |
Association between periodontitis and salivary nitric oxide metabolites among community elderly Koreans.
Topics: Aged; Aged, 80 and over; Biomarkers; Cohort Studies; Cross-Sectional Studies; Dentition; Diabetes Co | 2013 |
Novel diallyldisulfide analogs ameliorate cardiovascular remodeling in rats with L-NAME-induced hypertension.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Body Weight; Calcium; Cyclic GMP; Disulfide | 2012 |
Direct renin inhibitor prevents and ameliorates insulin resistance, aortic endothelial dysfunction and vascular remodeling in fructose-fed hypertensive rats.
Topics: Amides; Animals; Aorta, Thoracic; Dietary Carbohydrates; Disease Models, Animal; Endothelium, Vascul | 2013 |
Aerobic exercise reduces oxidative stress and improves vascular changes of small mesenteric and coronary arteries in hypertension.
Topics: Animals; Blood Pressure; Citrate (si)-Synthase; Collagen; Coronary Vessels; Heart Rate; Hypertension | 2013 |
Beneficial effect of genistein on lowering blood pressure and kidney toxicity in fructose-fed hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Diabetic Nephropathies; Diet; Dietary Sucrose; Fru | 2013 |
Effects of Cudrania tricuspidata water extract on blood pressure and renal functions in NO-dependent hypertension.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Blotting, Western; Body Weight; C | 2002 |
Endothelial function in sustained and white coat hypertension.
Topics: Adult; Blood Pressure Monitoring, Ambulatory; Body Mass Index; Brachial Artery; Endothelium, Vascula | 2002 |
Angiotensinogen gene knockout delays and attenuates cold-induced hypertension.
Topics: Angiotensinogen; Animals; Blood Pressure; Body Weight; Brain; Cold Temperature; Female; Gene Express | 2003 |
May nitric oxide molecule have a role in the pathogenesis of human cataract?
Topics: Adult; Aged; Aged, 80 and over; Cataract; Female; Humans; Hypertension; Lens, Crystalline; Male; Mid | 2003 |
Nitric oxide is a determinant of membrane fluidity of erythrocytes in postmenopausal women: an electron paramagnetic resonance investigation.
Topics: Aged; Blood Pressure; Electron Spin Resonance Spectroscopy; Erythrocyte Membrane; Female; Humans; Hy | 2003 |
The effect of different hypertension models on visual evoked potentials.
Topics: Animals; Disease Models, Animal; Evoked Potentials, Visual; Fluorometry; Hippocampus; Hypertension; | 2002 |
A nitric oxide-generating beta-blocking agent prevents renal injury in the rat remnant kidney model. Comparative study of two beta-blocking drugs, nipradilol and propranolol.
Topics: Adrenergic beta-Antagonists; Animals; Cyclic GMP; Enzyme Inhibitors; Hypertension; Kidney; Kidney Di | 2003 |
The interrelationship between TGF-beta1 and nitric oxide is altered in salt-sensitive hypertension.
Topics: Animals; Aorta; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; Mitogen-Activated Protei | 2003 |
Nitric oxide production and intensity of free radical processes in young men with high normal and hypertensive blood pressure.
Topics: Adult; Antioxidants; Blood Pressure; Free Radicals; Humans; Hypertension; Lipid Peroxidation; Male; | 2003 |
Endothelial dysfunction and reduced nitric oxide in resistance arteries in autosomal-dominant polycystic kidney disease.
Topics: Adult; Arginine; Arteries; Endothelium, Vascular; Female; Humans; Hypertension; Kidney Failure, Chro | 2003 |
[Therapy of angina pectoris and hypertension with nitrangin liquidum and nitrangin compositum].
Topics: Angina Pectoris; Hypertension; Nitrites; Nitroglycerin | 1952 |
[Hypotensive effect of nitro derivatives, in particular mannitol hexanitrate].
Topics: Humans; Hypertension; Hypotension; Mannitol; Nitrites | 1952 |
Nitranitol R. S. in the combined therapy of hypertension.
Topics: Alkaloids; Hypertension; Hypnotics and Sedatives; Nitrites; Psychotherapy, Multiple; Rauwolfia | 1955 |
Inositol and mannitol hexanitrates in hypertension management.
Topics: Disease Management; Hypertension; Inositol; Mannitol; Nitrites | 1955 |
The direct and reflex effects of injections of nitroglycerine and L-noradrenaline in normal and hypertensive rabbits.
Topics: Animals; Blood Pressure; Hypertension; Nitrites; Nitroglycerin; Norepinephrine; Rabbits; Reflex | 1955 |
A comparative study of the treatment of essential hypertension; the effect of Rauwolfia and a Rauwolfia compound (Rauwolfia, mannitol hexanitrate, and rutin).
Topics: Alkaloids; Antihypertensive Agents; Essential Hypertension; Flavonoids; Hypertension; Mannitol; Nitr | 1956 |
Vascular reactivity in experimental hypertension measured after hexamethonium.
Topics: Blood Vessels; Hexamethonium; Hypertension; Nitrites; Norepinephrine | 1958 |
Effects of sublingual nitroglycerin on pulmonary arterial pressure in patients with left ventricular failure.
Topics: Arterial Pressure; Heart Failure; Humans; Hypertension; Nitrites; Nitroglycerin | 1959 |
The flicker fusion threshold and its response to nitroglycerin in hypertension and in coarctation of the aorta.
Topics: Aorta; Aortic Coarctation; Flicker Fusion; Humans; Hypertension; Nitrites; Nitroglycerin | 1961 |
[The phosphate of triethanolamine trinitrate in the therapy of hypertension; its side-effects].
Topics: Ethanolamines; Hypertension; Nitrates; Nitrites; Phosphates | 1959 |
Conditioned reflex reproduction of the effects of novurit (mercurial diuretic) and nitroglycerin in patients with cardiac decompensation, hypertension and coronary insufficiency.
Topics: Alkylmercury Compounds; Conditioning, Classical; Coronary Disease; Diuretics; Drug Combinations; Hea | 1961 |
HEMODYNAMIC EFFECTS OF ISOSORBIDE DINITRATE IN PATIENTS WITH RHEUMATIC HEART DISEASE AND PULMONARY HYPERTENSION.
Topics: Hemodynamics; Humans; Hypertension; Hypertension, Pulmonary; Isosorbide Dinitrate; Nitrites; Rheumat | 1963 |
[ON THE EFFECT OF SODIUM NITRITE ON CEREBRAL CIRCULATION, PRESSURE OF THE CENTRAL RETINAL ARTERY AND CEREBROSPINAL FLUID PRESSURE].
Topics: Cerebrospinal Fluid; Cerebrospinal Fluid Pressure; Cerebrovascular Circulation; Humans; Hypertension | 1963 |
[CLINICAL TRIAL OF THE CORONARY CIRCULATION-STIMULATING DRUG ETAMIN].
Topics: Arteriosclerosis; Coronary Circulation; Coronary Disease; Gastritis; Geriatrics; Heart Failure; Hype | 1964 |
Clinical and electrocardiographic study of some cases of hypertension and angina pectoris treated with peritrate.
Topics: Aged; Angina Pectoris; Electrocardiography; Humans; Hypertension; Nitrites; Pentaerythritol Tetranit | 1955 |
[The role of the nervous system in medicamental effects. Part II. Investigations with conditioned reflexes after use of nitroglycerine in hypertensive persons and in patients suffering from coronary insufficiency].
Topics: Conditioning, Classical; Hypertension; Nervous System; Nervous System Physiological Phenomena; Nitri | 1959 |
Nitric oxide synthase activity in blood vessels of spontaneously hypertensive rats: antioxidant protection by gamma-tocotrienol.
Topics: Administration, Oral; Aging; Animals; Antioxidants; Blood Pressure; Blood Vessels; Chromans; Dose-Re | 2003 |
Factors involved in the development of hypertension induced by a low-protein diet in rats with renal injury.
Topics: Animals; Arginine; Blood Pressure; Cyclosporine; Diet, Protein-Restricted; Dietary Supplements; Hype | 2004 |
Circulating coupling factor 6 in human hypertension: role of reactive oxygen species.
Topics: Antioxidants; Ascorbic Acid; Biomarkers; Blood Pressure; Diet, Sodium-Restricted; Dinoprost; Endothe | 2003 |
[Gestational arterial hypertension. Mechanisms of formation. Treatment with normodipin].
Topics: Adolescent; Adult; Amlodipine; Antihypertensive Agents; Arm; Arteries; Blood Flow Velocity; Endothel | 2003 |
17beta-Oestradiol enhances aortic endothelium function and smooth muscle contraction in male spontaneously hypertensive rats.
Topics: Aging; Animals; Aorta, Thoracic; Culture Techniques; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; | 2004 |
The effect of hormone replacement therapy on endothelial function in postmenopausal women with hypertension.
Topics: Administration, Cutaneous; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambul | 2004 |
Effects of periodic body acceleration on the in vivo vasoactive response to N-omega-nitro-L-arginine and the in vitro nitric oxide production.
Topics: Acceleration; Animals; Aorta; Cardiac Output; Dose-Response Relationship, Drug; Endothelium, Vascula | 2003 |
Opposite effect of methionine-supplemented diet, a model of hyperhomocysteinemia, on plasma and liver antioxidant status in normotensive and spontaneously hypertensive rats.
Topics: Animals; Antioxidants; Biological Availability; Catalase; Copper; Cysteine; Diet; Dietary Supplement | 2004 |
Uncontrolled hypertension, uncompensated type II diabetes, and smoking have different patterns of vascular dysfunction.
Topics: Adult; Blood Flow Velocity; Cyclic GMP; Diabetes Mellitus, Type 2; Endothelium, Vascular; Humans; Hy | 2004 |
Roles of systemic nitric oxide metabolites for human coronary circulation.
Topics: Acetylcholine; Aorta; Cholesterol; Coronary Angiography; Coronary Circulation; Coronary Vasospasm; C | 2004 |
Inhibiting long chain fatty Acyl CoA synthetase increases basal and agonist-stimulated NO synthesis in endothelium.
Topics: Animals; Cells, Cultured; Choline; Coenzyme A Ligases; Coronary Vessels; Cytoplasm; Endothelial Cell | 2004 |
Increased expression of regulator of G protein signaling-2 (RGS-2) in Bartter's/Gitelman's syndrome. A role in the control of vascular tone and implication for hypertension.
Topics: Adult; Angiotensin II; Bartter Syndrome; Case-Control Studies; Cohort Studies; Creatinine; Cyclic GM | 2004 |
The role of renal natriuretic and depressor systems in insulin-resistant hypertensive rats.
Topics: Animals; Dopamine; Hypertension; Insulin Resistance; Kallikreins; Kidney; Male; Nitrates; Nitrites; | 2004 |
Attenuation of insulin-mediated pressor effect and nitric oxide release in rats with fructose-induced insulin resistance.
Topics: Animals; Blood Glucose; Blood Pressure; Fructose; Heart Rate; Hyperinsulinism; Hypertension; Insulin | 2004 |
Leptin and nitric oxide production in normotensive and hypertensive men.
Topics: Body Mass Index; Humans; Hypertension; Leptin; Male; Middle Aged; Nitrates; Nitric Oxide; Nitrites | 2004 |
Lipoic acid attenuates hypertension and improves insulin sensitivity, kallikrein activity and nitrite levels in high fructose-fed rats.
Topics: Animals; Biological Transport; Blood Glucose; Blood Pressure; Calcium-Transporting ATPases; Creatine | 2004 |
Systemic arterial pressure response to two weeks of Tempol therapy in SHR: involvement of NO, the RAS, and oxidative stress.
Topics: Acridines; Animals; Antihypertensive Agents; Blood Pressure; Cyclic N-Oxides; Dinoprost; Enzyme Inhi | 2005 |
The expression of heme oxygenase-1 and inducible nitric oxide synthase in aorta during the development of hypertension in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta; Biomarkers; Blood Pressure; Blotting, Western; Disease Mode | 2004 |
Nitrite is an alternative source of NO in vivo.
Topics: Administration, Oral; Animals; Blood Pressure; Electron Spin Resonance Spectroscopy; Enzyme Inhibito | 2005 |
Human eNOS gene delivery attenuates cold-induced elevation of blood pressure in rats.
Topics: Adenoviridae; Animals; Aorta, Abdominal; Blood Pressure; Cells, Cultured; Cold Temperature; Endothel | 2005 |
Increasing oxidative stress with molsidomine increases blood pressure in genetically hypertensive rats but not normotensive controls.
Topics: Animals; Blood Pressure; Hemodynamics; Hypertension; Kidney; Male; Molsidomine; Nitrates; Nitric Oxi | 2005 |
Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.
Topics: Acetophenones; Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Biopterins; Cardiomegaly; Dis | 2005 |
Angiotensin-converting enzyme inhibition and angiotensin AT1-receptor antagonism equally improve endothelial vasodilator function in L-NAME-induced hypertensive rats.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Co | 2005 |
Effects of chloride substitution in isolated mesenteric blood vessels from Dahl normotensive and hypertensive rats.
Topics: Animals; Chlorides; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Enz | 2005 |
Effects of losartan on blood pressure, oxidative stress, and nitrate/nitrite levels in the nitric oxide deficient hypertensive rats.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Body Weight; C | 2004 |
An association between plasma asymmetric dimethylarginine and membrane fluidity of erythrocytes in hypertensive and normotensive men: an electron paramagnetic resonance investigation.
Topics: Arginine; Electron Spin Resonance Spectroscopy; Erythrocyte Membrane; Humans; Hypertension; Male; Me | 2005 |
Endothelial cell activity in chronic obstructive pulmonary disease without severe pulmonary hypertension.
Topics: Cell Adhesion; Endothelial Cells; Female; Humans; Hypertension; Male; Nitrates; Nitrites; Pulmonary | 2005 |
Angiotensin II type 1 receptor antagonism improves endothelial vasodilator function in L-NAME-induced hypertensive rats by a kinin-dependent mechanism.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Co | 2006 |
Garlic supplementation prevents oxidative DNA damage in essential hypertension.
Topics: 8-Hydroxy-2'-Deoxyguanosine; alpha-Tocopherol; Antihypertensive Agents; Antioxidants; Ascorbic Acid; | 2005 |
Production of nitric oxide, lipid peroxidation and oxidase activity of ceruloplasmin in blood of elderly patients with primary hypertension. Effects of perindopril treatment.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antihypertensive Agents; Ceruloplasmin; Humans; Hypertension; | 2006 |
Nitric oxide and cell adhesion molecules in essential hypertension: a case control study.
Topics: Adult; Blood Pressure; Case-Control Studies; Cell Adhesion Molecules; E-Selectin; Female; Humans; Hy | 2006 |
Macrophage populations and cardiac sympathetic denervation during L-NAME-induced hypertension in rats.
Topics: Animals; Drug Therapy, Combination; Enzyme Inhibitors; Guanidines; Heart; Hemodynamics; Hypertension | 2006 |
Atorvastatin prevented and reversed dexamethasone-induced hypertension in the rat.
Topics: Analysis of Variance; Animals; Atorvastatin; Biomarkers; Blood Pressure; Body Weight; Dexamethasone; | 2006 |
Treatment with hypotensive agents affects the impaired relaxation of the penile corpus cavernosum in hypertensive rats.
Topics: Amlodipine; Animals; Antihypertensive Agents; Blood Pressure; Carbon Monoxide; Cyclic GMP; Electric | 2006 |
Possible role of exogenous cAMP to improve vascular endothelial dysfunction in hypertensive rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aorta; Atorvastatin; Blood Pressure; Cyclic AMP; Dr | 2006 |
Effect of sex hormones on non-esterified fatty acids, intra-abdominal fat accumulation, and hypertension induced by sucrose diet in male rats.
Topics: Animals; Blood Glucose; Blood Pressure; Body Weight; Dietary Sucrose; Disease Models, Animal; Estrad | 2006 |
Effects of acute and chronic L-arginine treatment in experimental hyperuricemia.
Topics: Animals; Arginine; Arterioles; Endothelium, Vascular; Hypertension; Hyperuricemia; Kidney Glomerulus | 2007 |
Effect of demethylasterriquinone b1 in hypertension associated vascular endothelial dysfunction.
Topics: Animals; Aorta, Thoracic; Atorvastatin; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutary | 2007 |
Preventive effects of green tea catechins on spontaneous stroke in rats.
Topics: Animals; Blood Pressure; Camellia sinensis; Catechin; Heart Rate; Hypertension; Male; Motor Activity | 2007 |
Influence of eNOS haplotypes on the plasma nitric oxide products concentrations in hypertensive and type 2 diabetes mellitus patients.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genotype; Haplotypes; Humans; Hypert | 2007 |
Isohumulones derived from hops ameliorate renal injury via an anti-oxidative effect in Dahl salt-sensitive rats.
Topics: Animals; Antioxidants; Blood Pressure; Blotting, Western; Cyclopentanes; Humulus; Hypertension; Kidn | 2007 |
Serum nitric oxide metabolite (NO(x)) levels in hypertensive patients at rest: a comparison of age, gender, blood pressure and complications using normotensive controls.
Topics: Adult; Age Distribution; Age Factors; Aged; Aged, 80 and over; Aging; Biomarkers; Blood Pressure; Ca | 2007 |
A moderately high fat diet promotes salt-sensitive hypertension in obese zucker rats by impairing nitric oxide production.
Topics: Animals; Body Weight; Diet; Dietary Fats; Disease Models, Animal; Feedback, Physiological; Female; H | 2007 |
[The nitric oxide system in patients with arterial hypertension living in high mountains].
Topics: Adult; Aged; Altitude; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Disease Progression; E | 2007 |
Simvastatin reverses the hypertension of heterozygous mice lacking cystathionine beta-synthase and apolipoprotein A-I.
Topics: Animals; Antihypertensive Agents; Aorta; Apolipoprotein A-I; Blood Pressure; Blotting, Western; Chro | 2008 |
Mother was right: eat your vegetables and do not spit! When oral nitrate helps with high blood pressure.
Topics: Beta vulgaris; Blood Pressure; Diet; Humans; Hypertension; Nitrates; Nitrites; Vegetables | 2008 |
[Oxygen-transport function of the blood and endothelial dysfunction in patients with angina pectoris and arterial hypertension].
Topics: Acidosis; Adult; Angina Pectoris; Endothelium, Vascular; Female; Hemoglobins; Humans; Hypertension; | 2007 |
Angiopoietin-1 prevents hypertension and target organ damage through its interaction with endothelial Tie2 receptor.
Topics: Angiopoietin-1; Animals; Antihypertensive Agents; Blood Pressure; Capillaries; Disease Models, Anima | 2008 |
Antioxidative effects of melatonin administration in elderly primary essential hypertension patients.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Antioxidants; Catalase; Glutathione; Glutathione P | 2008 |
Malignant alterations following early blockade of nitric oxide synthase in hypertensive rats.
Topics: Animals; Blood Pressure; Blood Urea Nitrogen; Body Weight; Endothelin-1; Enzyme Inhibitors; Glomerul | 2007 |
Soy protein hydrolysate ameliorates cardiovascular remodeling in rats with L-NAME-induced hypertension.
Topics: Alanine Transaminase; Animals; Aorta; Aspartate Aminotransferases; Blood Pressure; Hydrolysis; Hyper | 2008 |
Fluorescein studies of hypertensive retinopathy.
Topics: Adult; Animals; Arteriosclerosis; Blood Flow Velocity; Blood Pressure; Diabetic Retinopathy; Exudate | 1967 |
[Some cardiological problems in high mountains. Correlation with humans in flight].
Topics: Adrenergic beta-Antagonists; Aerospace Medicine; Altitude; Angina Pectoris; Arrhythmias, Cardiac; Di | 1980 |
Endogenous nitric oxide synthesis determines sensitivity to the pressor effect of salt.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Hypertension; Kidney Glomerulus; Male | 1994 |
Effects of prolonged L-arginine administration on blood pressure in patients with essential hypertension (EH).
Topics: Adult; Arginine; Blood Pressure; Cyclic GMP; Fibrinolysis; Heart Rate; Humans; Hypertension; Injecti | 1995 |
Effect of trichlormethiazide and captopril on nitric oxide synthase activity in the kidney of deoxycorticosterone acetate-salt hypertensive rats.
Topics: Animals; Antihypertensive Agents; Captopril; Desoxycorticosterone; Hypertension; Kidney; Kidney Glom | 1996 |
Mechanism of hypertension induced by chronic inhibition of nitric oxide in rats.
Topics: Animals; Arginine; Blood Pressure; Catecholamines; Enzyme Inhibitors; Heart Rate; Hemodynamics; Hype | 1995 |
Hypothalamic and plasma total nitrate/nitrite concentrations in spontaneously hypertensive rats.
Topics: Animals; Hypertension; Hypothalamus; Male; Nitrates; Nitrites; Rats; Rats, Inbred SHR; Rats, Inbred | 1996 |
Nitric oxide (NO) modulates the neurogenic control of blood pressure in rats with chronic renal failure (CRF).
Topics: Angiotensin II; Animals; Aorta; Arginine; Blood Pressure; Brain; Creatinine; Enzyme Inhibitors; Gene | 1997 |
Role of nitric oxide in lipopolysaccharide-induced mortality from spontaneously hypertensive rats.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherich | 1997 |
Enalapril and pressure-diuresis in hypertensive rats transgenic for mouse renin gene.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Genetically Modified; Antihypertensive A | 1997 |
Nitric oxide activity in childhood hypertension.
Topics: Biomarkers; Child; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Hypertension | 1997 |
Reduced plasma concentrations of nitrogen oxide in individuals with essential hypertension.
Topics: Female; Humans; Hypertension; Male; Middle Aged; Nitrates; Nitrites; Osmolar Concentration; Referenc | 1997 |
Altered nitric oxide metabolism and increased oxygen free radical activity in lead-induced hypertension: effect of lazaroid therapy.
Topics: Animals; Antioxidants; Hypertension; Lead; Male; Malondialdehyde; Nitrates; Nitric Oxide; Nitrites; | 1997 |
Glomerular basement membrane polyanionic sites and nitric oxide in genetically salt-sensitive and resistant hypertensive rats.
Topics: Animals; Basement Membrane; Creatinine; Drug Resistance; Hypertension; Kidney Glomerulus; Metabolic | 1997 |
Lead-induced hypertension: interplay of nitric oxide and reactive oxygen species.
Topics: Animals; Blood Pressure; Cerebellum; Cerebral Cortex; Cyclic GMP; Endothelin-1; Endothelin-3; Hypert | 1997 |
Plasma levels of nitrite/nitrate and platelet cGMP levels are decreased in patients with atrial fibrillation.
Topics: Aged; Atrial Fibrillation; beta-Thromboglobulin; Blood Platelets; Blood Proteins; Cerebrovascular Di | 1997 |
Extra-pulmonary effects of inhaled nitric oxide in swine with and without phenylephrine.
Topics: Administration, Inhalation; Animals; Diuresis; Female; Glomerular Filtration Rate; Hemodynamics; Hyp | 1997 |
Alterations of nitric oxide synthase expression with aging and hypertension in rats.
Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Endothelium, Vascular; Enzyme Induc | 1998 |
Garlic prevents hypertension induced by chronic inhibition of nitric oxide synthesis.
Topics: Animals; Blood Pressure; Garlic; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric | 1998 |
Nitric oxide in different types of hypertension during pregnancy.
Topics: Adult; Antihypertensive Agents; Female; Humans; Hypertension; Nitrates; Nitric Oxide; Nitrites; Plat | 1997 |
Role of increased oxygen free radical activity in the pathogenesis of uremic hypertension.
Topics: Animals; Antioxidants; Blood Pressure; Free Radical Scavengers; Hypertension; Kidney Failure, Chroni | 1998 |
Upregulation of renal and vascular nitric oxide synthase in young spontaneously hypertensive rats.
Topics: Age Factors; Animals; Aorta, Thoracic; Arginine; Blotting, Western; Body Weight; Creatinine; Data In | 1998 |
The nitric oxide system and cortisol-induced hypertension in humans.
Topics: Arginine; Humans; Hydrocortisone; Hypertension; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; | 1998 |
Role of nitric oxide in cyclosporine A-induced hypertension.
Topics: Animals; Aorta; Arginine; Blood Pressure; Bosentan; Cyclic GMP; Cyclosporine; Endothelin Receptor An | 1998 |
Decreased excretion of nitrate and nitrite in essential hypertensives with renal vasoconstriction.
Topics: Endothelium, Vascular; Female; Humans; Hypertension; Kidney; Male; Nitrates; Nitric Oxide; Nitrites; | 1998 |
Modulation of nitric oxide improves cyclosporin A-induced hypertension in rats and primates.
Topics: Animals; Antihypertensive Agents; Arginine; Blood Pressure; Bosentan; Callithrix; Cyclosporine; Enzy | 1998 |
Altered renal expression of nitric oxide synthase isozymes in spontaneously hypertensive rats.
Topics: Animals; Hypertension; Isoenzymes; Kidney; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitr | 1999 |
Higher level of plasma nitric oxide in spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Pressure; Enzyme Inhibitors; Hypertension; Lipopolysa | 1999 |
Effects of acute euglycemic hyperinsulinemia on urinary nitrite/nitrate excretion and plasma endothelin-1 levels in men with essential hypertension and normotensive controls.
Topics: Acute Disease; Adult; Blood Glucose; Endothelin-1; Humans; Hyperinsulinism; Hypertension; Male; Midd | 1999 |
Nitric oxide in cyclosporine A-induced hypertension: endothelin receptors gene expression.
Topics: Animals; Aorta; Arginine; Cyclosporine; Gene Expression; Hypertension; Male; Nitrates; Nitric Oxide; | 1999 |
Differentially-altered vascular guanylate cyclase isoforms in experimental hypertensive rats.
Topics: Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Blotting, Western; Desoxycorticosterone; Guanyl | 1999 |
Down-regulation of the expression of endothelial NO synthase is likely to contribute to glucocorticoid-mediated hypertension.
Topics: Animals; Aorta; Base Sequence; Cells, Cultured; Dexamethasone; DNA Primers; Down-Regulation; Endothe | 1999 |
Potassium supplementation increases sodium excretion and nitric oxide production in hypertensive Dahl rats.
Topics: Animals; Blood Pressure; Calcium; Hypertension; Kidney; Male; Natriuresis; Nitrates; Nitric Oxide; N | 1999 |
Influence of circadian time, ageing, and hypertension on the urinary excretion of nitric oxide metabolites in rats.
Topics: Aging; Animals; Creatinine; Diuresis; Drinking; Enzyme Inhibitors; Hypertension; Male; NG-Nitroargin | 1999 |
Role of glutathione in stabilization of nitric oxide during hypertension developed by inhibition of nitric oxide synthase in the rat.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Glutathione; Hypertension; Kidney; Male; Myocardium; NG- | 1999 |
Plasma nitric oxide metabolites and lipid peroxide levels in preeclamptic pregnant women before and after delivery.
Topics: Adult; Blood Pressure; Female; Gestational Age; Humans; Hypertension; Lipid Peroxides; Nitrates; Nit | 1999 |
Increased apoptosis susceptibility in mesangial cells from spontaneously hypertensive rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calcium; Cell Count; Cells, Cultured; Culture Media, | 2000 |
Gene transfer of endothelial nitric oxide synthase improves nitric oxide-dependent endothelial function in a hypertensive rat model.
Topics: Animals; Biological Availability; Blotting, Western; Carotid Arteries; Cells, Cultured; Endothelium, | 1999 |
Study on the relationship between plasma nitrite and nitrate level and salt sensitivity in human hypertension : modulation of nitric oxide synthesis by salt intake.
Topics: Adult; Aged; Arginine; Blood Pressure; Electrolytes; Female; Humans; Hypertension; Lipids; Male; Mid | 2000 |
Effects of angiotensin II type 1 receptor antagonist on nitric oxide synthase expression and myocardial remodeling in Goldblatt hypertensive rats.
Topics: Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blotting, Western; Bo | 2000 |
Role of nitric oxide in adaptation to hypoxia and adaptive defense.
Topics: Adaptation, Physiological; Animals; Aorta; Blood Pressure; Endothelium, Vascular; Hypertension; Hypo | 2000 |
Aldehyde induced hypertension in rats: prevention by N-acetyl cysteine.
Topics: Acetylcysteine; Aldehydes; Animals; Arterioles; Blood Platelets; Blood Pressure; Body Weight; Calciu | 1998 |
Potassium augments vascular relaxation mediated by nitric oxide in the carotid arteries of hypertensive Dahl rats.
Topics: Acetylcholine; Adenosine Diphosphate; Adrenergic beta-Agonists; Animals; Carotid Arteries; Colforsin | 2000 |
Glomerular basement membrane polyanion distribution and nitric oxide in spontaneous hypertensive rats: effects of salt loading and antihypertensive therapy with propranolol.
Topics: Animals; Antihypertensive Agents; Basement Membrane; Blood Pressure; Diet, Sodium-Restricted; Female | 2000 |
Protective effect of inducible type nitric oxide synthase against intracellular oxidative stress caused by advanced glycation end-products in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats.
Topics: Albumins; Animals; Cells, Cultured; Enzyme Inhibitors; Glutathione; Glycation End Products, Advanced | 2000 |
Mechanisms of salt-sensitive hypertension: role of inducible nitric oxide synthase.
Topics: Animals; Blood Pressure; Diuresis; Glomerular Filtration Rate; Guanidines; Hemodynamics; Hypertensio | 2000 |
The role of corticosterone in corticotrophin (ACTH)-induced hypertension in the rat.
Topics: Adrenocorticotropic Hormone; Animals; Arginine; Blood Pressure; Body Weight; Corticosterone; Drinkin | 2000 |
L-arginine partially reverses established adrenocorticotrophin-induced hypertension and nitric oxide deficiency in the rat.
Topics: Adrenocorticotropic Hormone; Amino Acids; Animals; Arginine; Citrulline; Cyclic GMP; Drug Evaluation | 2000 |
Endothelial dysfunction and xanthine oxidoreductase activity in rats with human renin and angiotensinogen genes.
Topics: Acetylcholine; Angiotensin II; Angiotensinogen; Animals; Animals, Genetically Modified; Antihyperten | 2001 |
Effect of oral L-arginine administration for three weeks in two kidney-two clip hypertensive rats.
Topics: Acetylcholine; Administration, Oral; Animals; Arginine; Blood Pressure; Body Weight; Epoprostenol; H | 2000 |
The role of nitric oxide and the renin-angiotensin system in salt-restricted Dahl rats.
Topics: Aldosterone; Animals; Blood Pressure; Diet, Sodium-Restricted; Down-Regulation; Glucuronidase; Hyper | 2001 |
L-Arginine improves endothelial function in renal artery of hypertensive Dahl rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Arginine | 2001 |
Vasopeptidase inhibition exhibits endothelial protection in salt-induced hypertension.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Blood Pressure; Capt | 2001 |
Effects of aging and alterations in dietary sodium intake on total nitric oxide production.
Topics: Adult; Age Factors; Aged; Aging; Blood Pressure; Cyclic GMP; Female; Humans; Hypertension; Male; Mid | 2001 |
Celiprolol stimulates endothelial nitric oxide synthase expression and improves myocardial remodeling in deoxycorticosterone acetate-salt hypertensive rats.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Blotting, Western; Celiprolol; Collagen; Desox | 2001 |
Decreased nitric oxide levels and increased calcium content in platelets of hypertensive patients.
Topics: Adult; Blood Platelets; Calcium; Cytosol; Female; Humans; Hypertension; Male; Middle Aged; Nitric Ox | 2001 |
Long-term effect of bilateral ovariectomy on endothelial function in aortic rings of spontaneously hypertensive rats: role of nitric oxide.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Body Weight; Endothelium, Vascular; Enzyme Inhibitors | 2001 |
Reduced baroreflex sensitivity and blunted endogenous nitric oxide synthesis precede the development of hypertension in TGR(mREN2)27 rats.
Topics: Animals; Animals, Genetically Modified; Baroreflex; Blood Pressure; Circadian Rhythm; Hypertension; | 2001 |
Compensatory up-regulation of nitric-oxide synthase isoforms in lead-induced hypertension; reversal by a superoxide dismutase-mimetic drug.
Topics: Animals; Antioxidants; Blood Pressure; Cyclic N-Oxides; Hypertension; Isoenzymes; Lead; Male; Nitrat | 2001 |
Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase.
Topics: Animals; Arteries; Blood Flow Velocity; Blood Glucose; Body Weight; Disease Models, Animal; Glucose; | 2001 |
Vasorelaxant effects of a nitric oxide-releasing aspirin derivative in normotensive and hypertensive rats.
Topics: Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Aspirin; Blood Pressure; Consci | 2001 |
Nitric oxide synthase (NOS2) mutation in Dahl/Rapp rats decreases enzyme stability.
Topics: Amino Acid Substitution; Animals; Arginine; Blotting, Northern; COS Cells; Cysteine Endopeptidases; | 2001 |
TCV-116 stimulates eNOS and caveolin-1 expression and improves coronary microvascular remodeling in normotensive and angiotensin II-induced hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arterioles; Benzimidazoles; Biphenyl Comp | 2001 |
Reciprocal regulation of cyclic GMP content by cyclic GMP-phosphodiesterase and guanylate cyclase in SHR with CsA-induced nephrotoxicity.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Body Weight; Cyclic GMP; Cyclosporine; Dose-Response R | 2001 |
Reduced expressions of inducible nitric oxide synthase and cyclooxygenase-2 in vascular smooth muscle cells of stroke-prone spontaneously hypertensive rats.
Topics: Animals; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; DNA Primers; Down-Regulation; Epopros | 2002 |
Tumor necrosis factor-alpha-induced hypertension in pregnant rats results in decreased renal neuronal nitric oxide synthase expression.
Topics: Animals; Blood Pressure; Female; Hypertension; Kidney; Neurons; Nitrates; Nitric Oxide Synthase; Nit | 2002 |
Effects of Choto-san on hemorheological factors and vascular function in stroke-prone spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Blood Pressure; Blood Viscosity; Body Weight; Dose-Response Relationship, Dr | 2002 |
Effect of exercise on blood pressure in rats with chronic NOS inhibition.
Topics: Adaptation, Physiological; Animals; Aorta; Blood Pressure; Body Weight; Chronic Disease; Heart; Hear | 2002 |
L-arginine as an antihypertensive agent.
Topics: Antihypertensive Agents; Arginine; Blood Pressure; Cardiac Output; Citrulline; Cushing Syndrome; Hum | 1992 |
Hemodynamic fndings in acute glomeruloenphritis.
Topics: Blood Pressure; Cardiac Catheterization; Cardiomegaly; Child; Child, Preschool; Digoxin; Diuresis; F | 1966 |
Evaluation of antihypertensive drugs in dogs with angiotensin-induced hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Disease Models, Animal; Dogs; Female; Hexamethoniu | 1971 |
Pharmacological properties of isoidide dinitrate.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Cats; Dogs; Hypertension; Nitrites; Pressoreceptors; R | 1965 |
Effects of the intraventricular administration of some hypotensive drugs on the arterial blood pressure and respiratory movements.
Topics: Acetylcholine; Animals; Arteries; Blood Pressure; Bretylium Compounds; Cerebral Ventricles; Dibenzyl | 1969 |