Page last updated: 2024-10-19

nitrites and Hyperglycemia

nitrites has been researched along with Hyperglycemia in 23 studies

Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)

Hyperglycemia: Abnormally high BLOOD GLUCOSE level.

Research Excerpts

ExcerptRelevanceReference
"We used two murine models of intrauterine exposures to maternal (a) hyperglycemia and (b) HFD to study the effects of these exposures on the L-arginine/NO metabolism in lung in normal chow-fed offspring."7.85Effects of fetal exposure to high-fat diet or maternal hyperglycemia on L-arginine and nitric oxide metabolism in lung. ( Gertsen, M; Grasemann, C; Grasemann, H; Herrmann, R; Palmert, MR; Starschinova, J, 2017)
" Resistin and uric acid, surrogate plasma markers of metabolic syndrome, were decreased."7.76Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice. ( Alfredo Martinez, J; Bour, S; Carpéné, C; Iffiú-Soltész, Z; Lomba, A; Milagro, FI; Pellati, F; Portillo, MP; Szöko, E; Valet, P; Wanecq, E; Woodley, J, 2010)
"We used two murine models of intrauterine exposures to maternal (a) hyperglycemia and (b) HFD to study the effects of these exposures on the L-arginine/NO metabolism in lung in normal chow-fed offspring."3.85Effects of fetal exposure to high-fat diet or maternal hyperglycemia on L-arginine and nitric oxide metabolism in lung. ( Gertsen, M; Grasemann, C; Grasemann, H; Herrmann, R; Palmert, MR; Starschinova, J, 2017)
" Resistin and uric acid, surrogate plasma markers of metabolic syndrome, were decreased."3.76Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice. ( Alfredo Martinez, J; Bour, S; Carpéné, C; Iffiú-Soltész, Z; Lomba, A; Milagro, FI; Pellati, F; Portillo, MP; Szöko, E; Valet, P; Wanecq, E; Woodley, J, 2010)
"Malondialdehyde (MA) (indicator of LP) in plasma and brain tissue, total nitrite/nitrate (metabolites of nitric oxide) in plasma, nitrite in brain tissue, and SOD in red blood cells were detected and the results were compared before and after VE administration in hyperglycemic rats with cerebral ischemia-reperfusion injury induced by two common carotid artery occlusions."3.74The effects of vitamin E on lipid peroxidation, nitric oxide production and superoxide dismutase expression in hyperglycemic rats with cerebral ischemia-reperfusion injury. ( Atükeren, P; Gümüştaş, K; Kaynar, MY; Kemerdere, R; Meta Güzeyli, FM; Sanus, GZ; Tanriverdi, T, 2007)
"Thalidomide treatment prevented hyperglycemia and preserved pancreatic insulin secretion in the diabetic mice."1.38Thalidomide attenuates multiple low-dose streptozotocin-induced diabetes in mice by inhibition of proinflammatory cytokines. ( Amirshahrokhi, K; Ghazi-Khansari, M, 2012)
"Hyperglycemia is known to inhibit ischemic and anesthetic preconditioning."1.36Hyperglycemia inhibits anesthetic-induced postconditioning in the rabbit heart via modulation of phosphatidylinositol-3-kinase/Akt and endothelial nitric oxide synthase signaling. ( Gozal, Y; Navot, N; Raphael, J; Zuo, Z, 2010)
"Hyperglycemia is frequently observed in nondiabetic patients during acute illness."1.35Hyperglycemia contributes to cardiac dysfunction in a lipopolysaccharide-induced systemic inflammation model. ( Asai, N; Hagiwara, S; Hasegawa, A; Iwasaka, H; Noguchi, T, 2009)
" We examined aortic endothelial cell function, NO bioavailability and various biomarkers of oxidative stress."1.35Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db mice. ( Brownsey, RW; Elmi, S; Ghosh, S; Khazaei, M; Kieffer, TJ; Laher, I; Moien-Afshari, F; Rahman, MM; Sallam, N, 2008)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (4.35)18.2507
2000's10 (43.48)29.6817
2010's9 (39.13)24.3611
2020's3 (13.04)2.80

Authors

AuthorsStudies
Cho, DH1
Sharma, N1
Gaikwad, AB1
Anand, CR1
Bhavya, B1
Jayakumar, K1
Harikrishnan, VS1
Gopala, S1
Fiorello, ML1
Treweeke, AT1
Macfarlane, DP1
Megson, IL1
Ramírez-Zamora, S1
Méndez-Rodríguez, ML1
Olguín-Martínez, M1
Sánchez-Sevilla, L1
Quintana-Quintana, M1
García-García, N1
Hernández-Muñoz, R1
Carlström, M1
Lundberg, JO1
Lai, YC1
Gladwin, MT1
Grasemann, C1
Herrmann, R1
Starschinova, J1
Gertsen, M1
Palmert, MR1
Grasemann, H1
Yoh, K1
Hirayama, A1
Ishizaki, K1
Yamada, A1
Takeuchi, M1
Yamagishi, S1
Morito, N1
Nakano, T1
Ojima, M1
Shimohata, H1
Itoh, K1
Takahashi, S1
Yamamoto, M1
Hagiwara, S1
Iwasaka, H1
Hasegawa, A1
Asai, N1
Noguchi, T1
Astort, F1
Repetto, EM1
Martínez Calejman, C1
Cipelli, JM1
Sánchez, R1
Di Gruccio, JM1
Mercau, M1
Pignataro, OP1
Arias, P1
Cymeryng, CB1
Portugal-Cohen, M1
Kohen, R1
Iffiú-Soltész, Z1
Wanecq, E1
Lomba, A1
Portillo, MP1
Pellati, F1
Szöko, E1
Bour, S1
Woodley, J1
Milagro, FI1
Alfredo Martinez, J1
Valet, P1
Carpéné, C1
Raphael, J1
Gozal, Y1
Navot, N1
Zuo, Z1
Joshi, MS1
Wattanapitayakul, S1
Schanbacher, BL1
Bauer, JA1
Amirshahrokhi, K1
Ghazi-Khansari, M1
Oomen, PH1
Kant, GD1
Dullaart, RP1
Tervaert, JW1
Reitsma, WD1
Smit, AJ1
Srinivasan, S1
Hatley, ME1
Bolick, DT1
Palmer, LA1
Edelstein, D1
Brownlee, M1
Hedrick, CC1
Miyazaki-Akita, A1
Hayashi, T1
Ding, QF1
Shiraishi, H1
Nomura, T1
Hattori, Y1
Iguchi, A1
Gümüştaş, K1
Meta Güzeyli, FM1
Atükeren, P1
Sanus, GZ1
Kemerdere, R1
Tanriverdi, T1
Kaynar, MY1
Moien-Afshari, F1
Ghosh, S1
Elmi, S1
Rahman, MM1
Sallam, N1
Khazaei, M1
Kieffer, TJ1
Brownsey, RW1
Laher, I1
Trachtman, H1
Futterweit, S1
Crimmins, DL1
Aydin, A1
Orhan, H1
Sayal, A1
Ozata, M1
Sahin, G1
Işimer, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Interaction of Polymorphism rs35652124 With Curcumin Supplementation on NFE2L2 Gene Expression, Antioxidant Capacity and Renal Function in Patients With Early Diabetic Nephropathy[NCT03262363]Phase 2/Phase 3176 participants (Anticipated)Interventional2018-08-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for nitrites and Hyperglycemia

ArticleYear
No effects of acute hyperglycaemia and hyperinsulinaemia on skin microcirculation and endothelial markers in Type II diabetes mellitus.
    Scandinavian journal of clinical and laboratory investigation, 2004, Volume: 64, Issue:2

    Topics: Antigens; Biomarkers; Capillary Permeability; Diabetes Mellitus, Type 2; Endothelial Cells; Fluoresc

2004

Other Studies

22 other studies available for nitrites and Hyperglycemia

ArticleYear
Telmisartan Inhibits Nitric Oxide Production and Vessel Relaxation via Protein Phosphatase 2A-mediated Endothelial NO Synthase-Ser
    Journal of Korean medical science, 2019, Nov-04, Volume: 34, Issue:42

    Topics: Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta; Cat

2019
Effects of renal ischemia injury on brain in diabetic and non-diabetic rats: Role of angiotensin II type 2 receptor and angiotensin-converting enzyme 2.
    European journal of pharmacology, 2020, Sep-05, Volume: 882

    Topics: Angiotensin-Converting Enzyme 2; Animals; Brain; Diabetes Mellitus, Experimental; Diminazene; Hyperg

2020
Inorganic nitrite alters mitochondrial dynamics without overt changes in cell death and mitochondrial respiration in cardiomyoblasts under hyperglycemia.
    Toxicology in vitro : an international journal published in association with BIBRA, 2021, Volume: 70

    Topics: Animals; Cell Death; Cell Line; Cell Respiration; Cell Survival; Glucose; Hyperglycemia; Membrane Po

2021
The impact of glucose exposure on bioenergetics and function in a cultured endothelial cell model and the implications for cardiovascular health in diabetes.
    Scientific reports, 2020, 11-11, Volume: 10, Issue:1

    Topics: Cardiovascular Diseases; Cell Death; Cell Line; Diabetes Mellitus; Endothelial Cells; Endothelium, V

2020
Increased erythrocytes by-products of arginine catabolism are associated with hyperglycemia and could be involved in the pathogenesis of type 2 diabetes mellitus.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Adult; Aged; Arginine; Blood Glucose; Carbon Isotopes; Case-Control Studies; Citrulline; Diabetes Me

2013
Letter by Carlström and Lundberg Regarding Article, "SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction".
    Circulation, 2016, Aug-09, Volume: 134, Issue:6

    Topics: AMP-Activated Protein Kinases; Heart Failure; Humans; Hyperglycemia; Hypertension, Pulmonary; Metfor

2016
Response by Lai and Gladwin to Letter Regarding Article, "SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction".
    Circulation, 2016, Aug-09, Volume: 134, Issue:6

    Topics: AMP-Activated Protein Kinases; Heart Failure; Humans; Hyperglycemia; Hypertension, Pulmonary; Metfor

2016
Effects of fetal exposure to high-fat diet or maternal hyperglycemia on L-arginine and nitric oxide metabolism in lung.
    Nutrition & diabetes, 2017, 02-20, Volume: 7, Issue:2

    Topics: Animals; Arginine; Diet, High-Fat; Female; Hyperglycemia; Lung; Mice; Nitrates; Nitric Oxide; Nitrit

2017
Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice.
    Genes to cells : devoted to molecular & cellular mechanisms, 2008, Volume: 13, Issue:11

    Topics: Animals; Electron Spin Resonance Spectroscopy; Female; Guanosine; Hyperglycemia; Kidney Diseases; Mi

2008
Hyperglycemia contributes to cardiac dysfunction in a lipopolysaccharide-induced systemic inflammation model.
    Critical care medicine, 2009, Volume: 37, Issue:7

    Topics: Animals; Cytokines; Disease Models, Animal; HMGB1 Protein; Hyperglycemia; Hypoglycemic Agents; Insul

2009
High glucose-induced changes in steroid production in adrenal cells.
    Diabetes/metabolism research and reviews, 2009, Volume: 25, Issue:5

    Topics: Analysis of Variance; Animals; Arginine; Cells, Cultured; Clone Cells; Dose-Response Relationship, D

2009
Exposure of human keratinocytes to ischemia, hyperglycemia and their combination induces oxidative stress via the enzymes inducible nitric oxide synthase and xanthine oxidase.
    Journal of dermatological science, 2009, Volume: 55, Issue:2

    Topics: Biomarkers; Cell Hypoxia; Cell Line; Cell Survival; Glucose; Glutathione; Glutathione Disulfide; Hum

2009
Chronic benzylamine administration in the drinking water improves glucose tolerance, reduces body weight gain and circulating cholesterol in high-fat diet-fed mice.
    Pharmacological research, 2010, Volume: 61, Issue:4

    Topics: Adipocytes; Administration, Oral; Animals; Aorta; Benzylamines; Blood Glucose; Cholesterol; Hydrogen

2010
Hyperglycemia inhibits anesthetic-induced postconditioning in the rabbit heart via modulation of phosphatidylinositol-3-kinase/Akt and endothelial nitric oxide synthase signaling.
    Journal of cardiovascular pharmacology, 2010, Volume: 55, Issue:4

    Topics: Anesthetics; Animals; Blood Glucose; Blood Pressure; Creatine Kinase, MB Form; Glucose; Heart; Heart

2010
Effects of human endothelial gene polymorphisms on cellular responses to hyperglycaemia: role of NOS3 (Glu298Asp) and ACE (I/D) polymorphisms.
    Diabetes & vascular disease research, 2011, Volume: 8, Issue:4

    Topics: Caveolin 1; Cell Death; Cells, Cultured; Diabetic Angiopathies; Genotype; Glucose; Human Umbilical V

2011
Thalidomide attenuates multiple low-dose streptozotocin-induced diabetes in mice by inhibition of proinflammatory cytokines.
    Cytokine, 2012, Volume: 60, Issue:2

    Topics: Administration, Oral; Animals; Cytokines; Diabetes Mellitus, Experimental; Dose-Response Relationshi

2012
Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells.
    Diabetologia, 2004, Volume: 47, Issue:10

    Topics: Animals; Aorta, Thoracic; Cells, Cultured; DNA Primers; Endothelium, Vascular; Glucose; Humans; Hype

2004
17beta-estradiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: relevance to postmenopausal diabetic cardiovascular disease.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 320, Issue:2

    Topics: Animals; Biopterins; Cardiovascular Diseases; Cattle; Cells, Cultured; Diabetes Complications; Down-

2007
The effects of vitamin E on lipid peroxidation, nitric oxide production and superoxide dismutase expression in hyperglycemic rats with cerebral ischemia-reperfusion injury.
    Turkish neurosurgery, 2007, Volume: 17, Issue:2

    Topics: Animals; Antioxidants; Blood Pressure; Brain Diseases; Diabetes Mellitus, Experimental; Hyperglycemi

2007
Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db mice.
    Diabetologia, 2008, Volume: 51, Issue:7

    Topics: Adipose Tissue; Animals; Antioxidants; Aorta; Body Weight; Diabetes Mellitus, Type 2; Diabetic Angio

2008
High glucose inhibits nitric oxide production in cultured rat mesangial cells.
    Journal of the American Society of Nephrology : JASN, 1997, Volume: 8, Issue:8

    Topics: Amino Acids; Animals; Arginine; Cells, Cultured; Diabetic Nephropathies; Glomerular Mesangium; Gluco

1997
Oxidative stress and nitric oxide related parameters in type II diabetes mellitus: effects of glycemic control.
    Clinical biochemistry, 2001, Volume: 34, Issue:1

    Topics: Adult; Aged; Case-Control Studies; Catalase; Cyclic GMP; Diabetes Mellitus, Type 2; Erythrocytes; Fe

2001