Page last updated: 2024-10-19

nitrites and Hyperemia

nitrites has been researched along with Hyperemia in 27 studies

Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)

Hyperemia: The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).

Research Excerpts

ExcerptRelevanceReference
" The aim of this study was to analyse the effects of a single session of resistance exercise on blood flow, reactive hyperemia, plasma nitrite, and plasma malondialdehyde in patients with peripheral artery disease."5.20A session of resistance exercise increases vasodilation in intermittent claudication patients. ( Brasileiro-Santos, M; Correia, M; Forjaz, CL; Lima, A; Miranda, A; Ritti-Dias, R; Santos, A; Silva, A; Sobral Filho, D, 2015)
" Forearm blood flow (FBF) during reactive hyperemia and after sublingual nitroglycerin (NTG) administration was measured by strain-gauge plethysmography."3.71Hormone replacement effects on endothelial function measured in the forearm resistance artery in normocholesterolemic and hypercholesterolemic postmenopausal women. ( Chayama, K; Higashi, Y; Kimura, M; Kodama, I; Nakagawa, K; Ohama, K; Sanada, M; Tsuda, M, 2002)
" The response of the resistance bed in the forearm after release of inflow occlusion (reactive hyperemia), to hand exercise, and to local heating and the response of the calf resistance vessels to arterial occlusion and intra-arterial sodium nitrite and phentolamine were studied in 23 patients with congestive heart failure and 21 normal subjects."3.64A comparison of the effects of vasodilator stimuli on peripheral resistance vessels in normal subjects and in patients with congestive heart failure. ( Braunwald, E; Mason, DT; Zelis, R, 1968)
"Blood withdrawal and reactive hyperemia index measurements were performed before and 10 min, 1 h, 2 h, and 4 h after transfusion."2.77Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers. ( Berra, L; Bloch, KD; Coppadoro, A; Dzik, WH; Feelisch, M; Fernandez, BO; Lei, C; Lin, T; Sammy, FY; Spagnolli, E; Steinbicker, AU; Stowell, CP; Warren, HS; Yu, B; Zapol, WM, 2012)
"Moreover, reactive hyperemia evaluated by strain-gauge plethysmography after 6 months (1."2.70Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by noninvasive evaluation. ( Higaki, J; Jinno, T; Katsuya, T; Komai, N; Matsumoto, K; Moriguchi, A; Ogihara, T; Ohishi, M; Rakugi, H; Yanagitani, Y, 2002)
"We measured ischemic reactive hyperemia (IRH), plasma levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), total nitrite, lipid peroxidation products (LPO), hydrogen peroxide (H2O2), superoxide dismutase (SOD) and glutathione peroxidase (GPx) plasma activities."1.39Oxidative stress is associated with the number of components of metabolic syndrome: LIPGENE study. ( Delgado-Lista, J; Fuentes, F; Lopez-Miranda, J; Marin, C; Peña-Orihuela, P; Perez-Jimenez, F; Perez-Martinez, P; Roche, HM; Tinahones, FJ; Tunez, I; Yubero-Serrano, EM, 2013)
"Both uncontrolled hypertension and type II diabetes mellitus, but not smoking, are associated with impaired vascular smooth-muscle reactivity induced by NO donors."1.32Uncontrolled hypertension, uncompensated type II diabetes, and smoking have different patterns of vascular dysfunction. ( Cittadino, M; Moreno, H; Sabha, M; Sousa, MG; Tácito, LH; Tanus-Santos, JE; Yugar-Toledo, JC, 2004)
"In reactive hyperemia in the hindlimb, the peak flow did not differ; however, both the repayment flow and the duration were significantly larger in pulsatile flow."1.31Pulsatile flow enhances endothelium-derived nitric oxide release in the peripheral vasculature. ( Nagano, I; Nakano, T; Okabe, H; Tominaga, R; Yasui, H, 2000)
"Portal hypertension is characterized by splanchnic hyperemia due to a reduction in mesenteric vascular resistance."1.29Increased endothelial nitric oxide synthase activity in the hyperemic vessels of portal hypertensive rats. ( Cahill, PA; Hodges, R; Redmond, EM; Sitzmann, JV; Zhang, S, 1996)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19902 (7.41)18.7374
1990's2 (7.41)18.2507
2000's9 (33.33)29.6817
2010's13 (48.15)24.3611
2020's1 (3.70)2.80

Authors

AuthorsStudies
Malishevskaya, TN1
Filippova, YE1
Rodrigues-Krause, J1
Krause, M1
Rocha, IMGD1
Umpierre, D1
Fayh, APT1
Nyberg, M1
Al-Khazraji, BK1
Mortensen, SP1
Jackson, DN1
Ellis, CG1
Hellsten, Y1
Yubero-Serrano, EM1
Delgado-Lista, J1
Peña-Orihuela, P1
Perez-Martinez, P1
Fuentes, F1
Marin, C1
Tunez, I1
Tinahones, FJ1
Perez-Jimenez, F1
Roche, HM1
Lopez-Miranda, J1
Rassaf, T1
Totzeck, M1
Hendgen-Cotta, UB1
Shiva, S1
Heusch, G1
Kelm, M1
Lima, A1
Ritti-Dias, R1
Forjaz, CL1
Correia, M1
Miranda, A1
Brasileiro-Santos, M1
Santos, A1
Sobral Filho, D1
Silva, A1
Pettit, AP1
Kipen, H1
Laumbach, R1
Ohman-Strickland, P1
Kelly-McNeill, K1
Cepeda, C1
Fan, ZH1
Amorosa, L1
Lubitz, S1
Schneider, S1
Gow, A1
Piknova, B1
Park, JW1
Kwan Jeff Lam, K1
Schechter, AN1
Djurica, D1
Holt, RR1
Ren, J1
Shindel, AW1
Hackman, RM1
Keen, CL1
Lima, AHRA1
Correia, MA1
Soares, AHG1
Farah, BQ1
Forjaz, CLM1
Silva, AS1
Brasileiro-Santos, MS1
Santos, AC1
Ritti-Dias, RM1
Schwarz, A1
Modun, D1
Heusser, K1
Tank, J1
Gutzki, FM1
Mitschke, A1
Jordan, J1
Tsikas, D1
Kapil, V1
Milsom, AB1
Okorie, M1
Maleki-Toyserkani, S1
Akram, F1
Rehman, F1
Arghandawi, S1
Pearl, V1
Benjamin, N1
Loukogeorgakis, S1
Macallister, R1
Hobbs, AJ1
Webb, AJ1
Ahluwalia, A1
García, RG1
Zarruk, JG1
Barrera, C1
Pinzón, A1
Trillos, E1
Arenas, WD1
Luengas, C1
Tomaz, C1
López-Jaramillo, P1
Berra, L1
Coppadoro, A1
Yu, B1
Lei, C1
Spagnolli, E1
Steinbicker, AU1
Bloch, KD1
Lin, T1
Sammy, FY1
Warren, HS1
Fernandez, BO1
Feelisch, M1
Dzik, WH1
Stowell, CP1
Zapol, WM1
Sanada, M2
Higashi, Y2
Nakagawa, K2
Tsuda, M2
Kodama, I2
Kimura, M1
Chayama, K1
Ohama, K2
Yugar-Toledo, JC1
Tanus-Santos, JE1
Sabha, M1
Sousa, MG1
Cittadino, M1
Tácito, LH1
Moreno, H1
Bustamante, SA1
Sanches, N1
Crosier, J1
Miranda, D1
Colombo, G1
Miller, MJ1
Cahill, PA1
Redmond, EM1
Hodges, R1
Zhang, S1
Sitzmann, JV1
Nakano, T1
Tominaga, R1
Nagano, I1
Okabe, H1
Yasui, H1
Lind, L1
Hall, J1
Larsson, A1
Annuk, M1
Fellström, B1
Lithell, H1
Najarian, T2
Marrache, AM1
Dumont, I1
Hardy, P2
Beauchamp, MH2
Hou, X2
Peri, K1
Gobeil, F2
Varma, DR2
Chemtob, S2
Sasaki, S1
Sakashita, T1
Egan, CG1
Lockhart, JC1
Ferrell, WR1
Day, SM1
McLean, JS1
Komai, N1
Ohishi, M1
Moriguchi, A1
Yanagitani, Y1
Jinno, T1
Matsumoto, K1
Katsuya, T1
Rakugi, H1
Higaki, J1
Ogihara, T1
Checchin, D1
Abran, D1
Bernier, SG1
Quiniou, C1
Uzoukwu, M1
Sleight, SD1
Zelis, R1
Mason, DT1
Braunwald, E1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomised Controlled Trial of the Effect of Remote Ischaemic Conditioning on Coronary Endothelial Function in Patients With Angina.[NCT02666235]Phase 260 participants (Actual)Interventional2011-07-31Completed
The Impact of Dietary Cocoa Flavanols on Cardio-pulmonary Exercise Capacity in Human.[NCT01259739]13 participants (Actual)Interventional2010-11-30Completed
Investigation of the Sex Differences in Oral Microbiota and Their Effect on Circulating Nitrite Levels[NCT01583803]24 participants (Anticipated)Observational2012-06-30Active, not recruiting
The Acute Effect of Beetroot Juice on Circulating Nitrate and Nitrite Levels and Blood Pressure in Normotensives and Hypertensives[NCT01236872]15 participants (Actual)Interventional2009-12-31Completed
Red Cell Storage Duration Study[NCT00991341]Phase 31,481 participants (Actual)Interventional2010-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

All-cause Mortality

Subjects were randomized for RECESS no earlier than one calendar day before the planned date of surgery, and were followed for all-cause mortality until post-operative Day 28, death, or study withdrawal, whichever occurred first. In some cases the surgery was postponed after randomization had already occurred. If surgery did not occur within 30 days after randomization, the subject ended the study and was not considered evaluable. If surgery did occur within 30 days after randomization, and the subject received at least one RBC transfusion between randomization and 96 hours after the end of surgery, the subject was considered evaluable. Therefore, in a few evaluable subjects, post-operative Day 28 could be nearly two months after the date of randomization. The times in the time-to-event analysis started at randomization. (NCT00991341)
Timeframe: 28 days post-surgery

Interventionparticipants with event (Number)
Shorter-storage Red Blood Cell Units23
Longer-storage Red Blood Cell Units29

Any Mechanical Ventilation More Than 48 Hours Post-operation

(NCT00991341)
Timeframe: 48 hours post-operation through day 28, hospital discharge, or death, whichever occurs first

Interventionparticipants with event (Number)
Shorter-storage Red Blood Cell Units68
Longer-storage Red Blood Cell Units80

Change in Bilirubin From Pre-operative Value to Worst Post-operative Value

(NCT00991341)
Timeframe: Through post-operative day 7, hospital discharge, or death, whichever occurs first

Interventionmg/dL (Mean)
Shorter-storage Red Blood Cell Units0.85
Longer-storage Red Blood Cell Units1.49

Change in Lactate From Pre-operative Value to Worst Post-operative Value

The arterial lactate levels were adjusted to make them comparable to venous lactate levels. (NCT00991341)
Timeframe: Through post-operative day 7, hospital discharge, or death, whichever occurs first

Interventionmmol/L (Mean)
Shorter-storage Red Blood Cell Units2.30
Longer-storage Red Blood Cell Units2.92

Change in Multiple Organ Dysfunction Score From Pre-operative Baseline.

The follow-up MODS used to calculate 28-day ΔMODS from pre-op baseline was based on the worst value of each component of MODS observed through post-op day 28, hospital discharge, or death, whichever occurred first, even if a subject's worst values for different components occurred on different dates. Subjects who died during this time period were assigned the worst possible follow-up MODS score, 24 points, and each component of MODS was set at 4, which is the worst score. If a subject did not die during this time period but had at least one day where the Glasgow Coma Score couldn't be scored[subject sedated; neurologic function not normal by pre-op history (prior stroke, tumor or trauma sequelae, cognitively challenged, behavioral disorder, etc.) or intra-op history, but currently unable to assess because of sedation], then a post-op MODS score was set to missing and a 28-day ΔMODS was not computed. The total MODS score ranges from 0 (best possible) to 24 points (worst possible). (NCT00991341)
Timeframe: Through 28 days post-surgery, hospital discharge, or death, whichever occurs first

InterventionMOD score points (Mean)
Shorter-storage Red Blood Cell Units8.74
Longer-storage Red Blood Cell Units9.07

Change in Serum Creatinine From Pre-operative Value to Worst Post-operative Value

(NCT00991341)
Timeframe: Through post-operative day 7, hospital discharge, or death, whichever occurs first

Interventionmg/dL (Mean)
Shorter-storage Red Blood Cell Units0.35
Longer-storage Red Blood Cell Units0.35

Change in Troponin-I From Pre-operative Value to Worst Post-operative Value

(NCT00991341)
Timeframe: Through post-operative day 7, hospital discharge, or death, whichever occurs first

Interventionng/mL (Mean)
Shorter-storage Red Blood Cell Units15.82
Longer-storage Red Blood Cell Units14.06

Composite of Major Cardiac Events (Death, Myocardial Infarction, Low Cardiac Output, Ventricular Tachycardia, Ventricular Fibrillation)

(NCT00991341)
Timeframe: Through post-operative day 7, hospital discharge, or death, whichever occurs first

Interventionparticipants with event (Number)
Shorter-storage Red Blood Cell Units206
Longer-storage Red Blood Cell Units230

Composite of Major In-hospital Post-operative Complications (Death, Stroke, Myocardial Infarction, Renal Failure, Culture-proven Sepsis/Septic Shock)

(NCT00991341)
Timeframe: Through post-operative day 7, hospital discharge, or death, whichever occurs first

Interventionparticipants with event (Number)
Shorter-storage Red Blood Cell Units91
Longer-storage Red Blood Cell Units87

Composite of Major Pulmonary Events (Any Mechanical Ventilation From 48 Hours Post-operation to Day 7, Hospital Discharge or Death, Whichever Comes First, or Pulmonary Embolism)

(NCT00991341)
Timeframe: Through post-operative day 7, hospital discharge, or death, whichever occurs first

Interventionparticipants with event (Number)
Shorter-storage Red Blood Cell Units62
Longer-storage Red Blood Cell Units75

Days Alive and Ventilator Free Through Post-op Day 28

(NCT00991341)
Timeframe: Through post-op day 28

Interventiondays (Mean)
Shorter-storage Red Blood Cell Units25.38
Longer-storage Red Blood Cell Units25.17

Days to First Bowel Movement

Subjects were randomized for RECESS no earlier than one calendar day before the planned date of surgery, and were followed until post-operative Day 28, death, or study withdrawal, whichever occurred first. In some cases the surgery was postponed after randomization had already occurred. If surgery did not occur within 30 days after randomization, the subject ended the study and was not considered evaluable. If surgery did occur within 30 days after randomization, and the subject received at least one RBC transfusion between randomization and 96 hours after the end of surgery, the subject was considered evaluable. Therefore, in a few evaluable subjects, post-operative Day 28 could be nearly two months after the date of randomization. The times in the time-to-event analyses are from randomization to first post-operative bowel movement. (NCT00991341)
Timeframe: Through post-operative day 28, hospital discharge, or death, whichever occurs first

Interventiondays (Mean)
Shorter-storage Red Blood Cell Units5.89
Longer-storage Red Blood Cell Units6.62

Days to First Solid Food

Subjects were randomized for RECESS no earlier than one calendar day before the planned date of surgery, and were followed until post-operative Day 28, death, or study withdrawal, whichever occurred first. In some cases the surgery was postponed after randomization had already occurred. If surgery did not occur within 30 days after randomization, the subject ended the study and was not considered evaluable. If surgery did occur within 30 days after randomization, and the subject received at least one RBC transfusion between randomization and 96 hours after the end of surgery, the subject was considered evaluable. Therefore, in a few evaluable subjects, post-operative Day 28 could be nearly two months after the date of randomization. The times in the time-to-event analyses are from randomization to first post-operative solid food. (NCT00991341)
Timeframe: Through post-operative day 28, hospital discharge, or death, whichever occurs first

Interventiondays (Mean)
Shorter-storage Red Blood Cell Units5.73
Longer-storage Red Blood Cell Units6.18

The Change in the Composite Multiple Organ Dysfunction Score (MODS) From the Pre-operative Baseline. The Worst Post-operative Values of Each Component of MODS Will be Used to Calculate the Change in MODS.

The follow-up MODS used to calculate 7-day ΔMODS from pre-op baseline was based on the worst value of each component of MODS observed through post-op day 7, hospital discharge, or death, whichever occurred first, even if a subject's worst values for different components occurred on different dates. Subjects who died during this time period were assigned the worst possible follow-up MODS score, 24 points, and each component of MODS was set at 4, which is the worst score. If a subject did not die during this time period but had at least one day where the Glasgow Coma Score couldn't be scored [subject sedated; neurologic function not normal by pre-op history (prior stroke, tumor or trauma sequelae, cognitively challenged, behavioral disorder, etc.) or intra-op history, but currently unable to assess because of sedation], then a post-op MODS score was set to missing and a 7-day ΔMODS was not computed. The total MODS score ranges from 0 (best possible) to 24 points (worst possible). (NCT00991341)
Timeframe: Through post-operative day 7, hospital discharge, or death, whichever occurs first

InterventionMOD score points (Mean)
Shorter-storage Red Blood Cell Units8.49
Longer-storage Red Blood Cell Units8.66

Ventilation Duration

Because some subjects may experience multiple periods of ventilator use, the total duration that they were on a ventilator was compared between the two groups. (NCT00991341)
Timeframe: Through post-operative day 28, hospital discharge, or death, whichever occurs first

Interventiondays (Mean)
Shorter-storage Red Blood Cell Units2.7
Longer-storage Red Blood Cell Units2.8

Reviews

1 review available for nitrites and Hyperemia

ArticleYear
Association of l-Arginine Supplementation with Markers of Endothelial Function in Patients with Cardiovascular or Metabolic Disorders: A Systematic Review and Meta-Analysis.
    Nutrients, 2018, Dec-20, Volume: 11, Issue:1

    Topics: Adult; Aged; Arginine; Cardiovascular Diseases; Diabetes Mellitus; Dietary Supplements; Endothelium,

2018

Trials

9 trials available for nitrites and Hyperemia

ArticleYear
Circulating nitrite contributes to cardioprotection by remote ischemic preconditioning.
    Circulation research, 2014, May-09, Volume: 114, Issue:10

    Topics: Animals; Forearm; Hindlimb; Humans; Hyperemia; Ischemic Preconditioning; Ischemic Preconditioning, M

2014
Circulating nitrite contributes to cardioprotection by remote ischemic preconditioning.
    Circulation research, 2014, May-09, Volume: 114, Issue:10

    Topics: Animals; Forearm; Hindlimb; Humans; Hyperemia; Ischemic Preconditioning; Ischemic Preconditioning, M

2014
Circulating nitrite contributes to cardioprotection by remote ischemic preconditioning.
    Circulation research, 2014, May-09, Volume: 114, Issue:10

    Topics: Animals; Forearm; Hindlimb; Humans; Hyperemia; Ischemic Preconditioning; Ischemic Preconditioning, M

2014
Circulating nitrite contributes to cardioprotection by remote ischemic preconditioning.
    Circulation research, 2014, May-09, Volume: 114, Issue:10

    Topics: Animals; Forearm; Hindlimb; Humans; Hyperemia; Ischemic Preconditioning; Ischemic Preconditioning, M

2014
A session of resistance exercise increases vasodilation in intermittent claudication patients.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2015, Volume: 40, Issue:1

    Topics: Aged; Endothelium, Vascular; Female; Humans; Hyperemia; Hypertension; Intermittent Claudication; Leg

2015
Effects of a dietary strawberry powder on parameters of vascular health in adolescent males.
    The British journal of nutrition, 2016, Volume: 116, Issue:4

    Topics: Adolescent; Beverages; Biomarkers; Cardiovascular Diseases; Cross-Over Studies; Diet; Double-Blind M

2016
Acute effects of walking and combined exercise on oxidative stress and vascular function in peripheral artery disease.
    Clinical physiology and functional imaging, 2018, Volume: 38, Issue:1

    Topics: Aged; Ankle Brachial Index; Biomarkers; Blood Pressure; Female; Hemodynamics; Humans; Hyperemia; Int

2018
Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.
    Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:2

    Topics: Blood Pressure; Brachial Artery; Cardiovascular Diseases; Cross-Over Studies; Cyclic GMP; Double-Bli

2010
Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.
    Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:2

    Topics: Blood Pressure; Brachial Artery; Cardiovascular Diseases; Cross-Over Studies; Cyclic GMP; Double-Bli

2010
Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.
    Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:2

    Topics: Blood Pressure; Brachial Artery; Cardiovascular Diseases; Cross-Over Studies; Cyclic GMP; Double-Bli

2010
Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.
    Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:2

    Topics: Blood Pressure; Brachial Artery; Cardiovascular Diseases; Cross-Over Studies; Cyclic GMP; Double-Bli

2010
Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers.
    Anesthesiology, 2012, Volume: 117, Issue:1

    Topics: Adult; Blood Preservation; Blood Transfusion, Autologous; Cross-Over Studies; Female; Hemolysis; Hum

2012
Evaluation of endothelium-dependent vasodilation in the human peripheral circulation.
    Clinical physiology (Oxford, England), 2000, Volume: 20, Issue:6

    Topics: Adult; Aged; Brachial Artery; Endothelium, Vascular; Female; Forearm; Humans; Hyperemia; Male; Metha

2000
Estrogen replacement therapy in postmenopausal women augments reactive hyperemia in the forearm by reducing angiotensin converting enzyme activity.
    Atherosclerosis, 2001, Volume: 158, Issue:2

    Topics: Blood Flow Velocity; Endothelium, Vascular; Estrogen Replacement Therapy; Estrogens, Conjugated (USP

2001
Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by noninvasive evaluation.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2002, Volume: 25, Issue:1

    Topics: Adrenergic alpha-Antagonists; Aorta; Arteriosclerosis; Doxazosin; Elasticity; Endothelium, Vascular;

2002

Other Studies

17 other studies available for nitrites and Hyperemia

ArticleYear
[The effect of antioxidant therapy on some pathogenetic factors of primary open-angle glaucoma].
    Vestnik oftalmologii, 2023, Volume: 139, Issue:4

    Topics: Aged; Antioxidants; Cholesterol; Endothelin-1; Glaucoma, Open-Angle; Humans; Hyperemia; Nitrites

2023
Effect of extraluminal ATP application on vascular tone and blood flow in skeletal muscle: implications for exercise hyperemia.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2013, Aug-01, Volume: 305, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Triphosphate; Adult; Animals; Blood Flow Velocity; Cells, Cu

2013
Oxidative stress is associated with the number of components of metabolic syndrome: LIPGENE study.
    Experimental & molecular medicine, 2013, Jun-21, Volume: 45

    Topics: Aged; Anthropometry; Antioxidants; Biomarkers; Blood Pressure; Endothelium, Vascular; Female; Glutat

2013
Disrupted Nitric Oxide Metabolism from Type II Diabetes and Acute Exposure to Particulate Air Pollution.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Aged; Air Filters; Air Pollution; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Humans;

2015
Nitrate as a source of nitrite and nitric oxide during exercise hyperemia in rat skeletal muscle.
    Nitric oxide : biology and chemistry, 2016, 05-01, Volume: 55-56

    Topics: Animals; Hyperemia; Male; Muscle, Skeletal; Nitrates; Nitric Oxide; Nitrites; Physical Conditioning,

2016
Stable-isotope dilution GC-MS approach for nitrite quantification in human whole blood, erythrocytes, and plasma using pentafluorobenzyl bromide derivatization: nitrite distribution in human blood.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011, May-15, Volume: 879, Issue:17-18

    Topics: Erythrocytes; Fluorobenzenes; Gas Chromatography-Mass Spectrometry; Humans; Hyperemia; Isotope Label

2011
Plasma nitrate levels and flow-mediated vasodilation in untreated major depression.
    Psychosomatic medicine, 2011, Volume: 73, Issue:4

    Topics: Adolescent; Adult; Blood Flow Velocity; Brachial Artery; Cardiovascular Diseases; Case-Control Studi

2011
Hormone replacement effects on endothelial function measured in the forearm resistance artery in normocholesterolemic and hypercholesterolemic postmenopausal women.
    The Journal of clinical endocrinology and metabolism, 2002, Volume: 87, Issue:10

    Topics: Arteries; Blood Flow Velocity; Cholesterol, HDL; Cholesterol, LDL; Endothelium, Vascular; Estradiol;

2002
Uncontrolled hypertension, uncompensated type II diabetes, and smoking have different patterns of vascular dysfunction.
    Chest, 2004, Volume: 125, Issue:3

    Topics: Adult; Blood Flow Velocity; Cyclic GMP; Diabetes Mellitus, Type 2; Endothelium, Vascular; Humans; Hy

2004
Dietary nucleotides: effects on the gastrointestinal system in swine.
    The Journal of nutrition, 1994, Volume: 124, Issue:1 Suppl

    Topics: Adenosine; Animals; Animals, Newborn; Animals, Suckling; Diet; Digestive System; DNA; Granulocytes;

1994
Increased endothelial nitric oxide synthase activity in the hyperemic vessels of portal hypertensive rats.
    Journal of hepatology, 1996, Volume: 25, Issue:3

    Topics: Animals; Blotting, Western; Cyclic GMP; Endothelium, Vascular; Enzyme Induction; Humans; Hyperemia;

1996
Pulsatile flow enhances endothelium-derived nitric oxide release in the peripheral vasculature.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 278, Issue:4

    Topics: Angiotensin II; Animals; Blood Pressure; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; C

2000
Prolonged hypercapnia-evoked cerebral hyperemia via K(+) channel- and prostaglandin E(2)-dependent endothelial nitric oxide synthase induction.
    Circulation research, 2000, Dec-08, Volume: 87, Issue:12

    Topics: Acidosis; Animals; Calcium Signaling; Carbon Dioxide; Dinoprostone; Disease Models, Animal; Dose-Res

2000
Pathophysiological basis of acute inflammatory hyperaemia in the rat knee: roles of cyclo-oxygenase-1 and -2.
    The Journal of physiology, 2002, Mar-01, Volume: 539, Issue:Pt 2

    Topics: Animals; Arthritis, Experimental; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Ede

2002
PGE(2)-mediated eNOS induction in prolonged hypercapnia.
    Investigative ophthalmology & visual science, 2002, Volume: 43, Issue:5

    Topics: Animals; Blood Flow Velocity; Calcium; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Dactinom

2002
Lactic and succinic dehydrogenase activity in nitrite toxicosis in the guinea pig.
    American journal of veterinary research, 1970, Volume: 31, Issue:2

    Topics: Animals; Appetite Depressants; Body Weight; Guinea Pigs; Hemoglobins; Hyperemia; Hypoxia; Kidney; L-

1970
A comparison of the effects of vasodilator stimuli on peripheral resistance vessels in normal subjects and in patients with congestive heart failure.
    The Journal of clinical investigation, 1968, Volume: 47, Issue:4

    Topics: Adult; Forearm; Heart Failure; Hot Temperature; Humans; Hyperemia; Leg; Middle Aged; Nitrites; Phent

1968