nitrites has been researched along with Hemolysis in 39 studies
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In parallel, hemolysis was assessed by measuring cell-free hemoglobin (Hb) and free heme (hemin)." | 3.81 | Predicting storage-dependent damage to red blood cells using nitrite oxidation kinetics, peroxiredoxin-2 oxidation, and hemoglobin and free heme measurements. ( Harper, V; Marques, MB; Oh, JY; Patel, RP; Stapley, R, 2015) |
| "In this study, we aimed to investigate the relationship between chronic hemolysis and increased body iron burden with development of premature atherosclerosis by carotid intima-media thickness (IMT), ferritin, serum lipid profile, homocysteine, nitrate/nitrite, and chitotriosidase enzyme activity in children with β-thalassemia major." | 3.78 | Premature atherosclerosis in children with β-thalassemia major. ( Altun, D; Aydin, A; Gursel, O; Ileri, T; Kocaoglu, M; Kurekci, AE; Kurt, I; Okutan, V; Ozcan, O; Tapan, S; Tascilar, E, 2012) |
| "Blood withdrawal and reactive hyperemia index measurements were performed before and 10 min, 1 h, 2 h, and 4 h after transfusion." | 2.77 | Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers. ( Berra, L; Bloch, KD; Coppadoro, A; Dzik, WH; Feelisch, M; Fernandez, BO; Lei, C; Lin, T; Sammy, FY; Spagnolli, E; Steinbicker, AU; Stowell, CP; Warren, HS; Yu, B; Zapol, WM, 2012) |
| " The data also suggest that concomitant treatment with NAR can restore NO bioavailability through either its metal-chelating properties or its antioxidant activity." | 1.40 | Erythrocyte nitric oxide synthase as a surrogate marker for mercury-induced vascular damage: the modulatory effects of naringin. ( Abo-Salem, OM; Attiaa, SM; Harisa, GI; Mariee, AD, 2014) |
| "Plasma hemoglobin (Hb) released during intravascular hemolysis has been associated with numerous deleterious effects that may stem from increased nitric oxide (NO) scavenging, but has also been associated with reactive oxygen species generation and platelet activation." | 1.38 | Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin. ( Bellavia, L; Bruce King, S; Ferreyra, GA; Gladwin, MT; Helms, CC; Kern, SJ; Kim-Shapiro, DB; McPhail, LC; Natanson, C; Perlegas, A; Piknova, B; Raat, NJ; Schechter, AN; Solomon, SB; Sun, J; Sweeney, D, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (41.03) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (20.51) | 29.6817 |
| 2010's | 14 (35.90) | 24.3611 |
| 2020's | 1 (2.56) | 2.80 |
| Authors | Studies |
|---|---|
| Bezerra, ÉA | 1 |
| Alves, MMM | 1 |
| Amorim, LV | 1 |
| Carvalho, RCV | 1 |
| Cruz, LPL | 1 |
| Costa-Júnior, JS | 1 |
| Oliveira, MDDA | 1 |
| Lima Neto, JS | 1 |
| Carvalho, FAA | 1 |
| Citó, AMDGL | 1 |
| Arcanjo, DDR | 1 |
| Halim, AA | 1 |
| Alsayed, B | 1 |
| Embarak, S | 1 |
| Yaseen, T | 1 |
| Dabbous, S | 1 |
| Fontaine, O | 1 |
| Dueluzeau, R | 1 |
| Raibaud, P | 1 |
| Chabanet, C | 1 |
| Popoff, MR | 1 |
| Badoual, J | 1 |
| Gabilan, JC | 1 |
| Andremont, A | 1 |
| Gómez, L | 1 |
| Andrés, S | 1 |
| Sánchez, J | 1 |
| Alonso, JM | 1 |
| Rey, J | 1 |
| López, F | 1 |
| Jiménez, A | 1 |
| Yan, Z | 1 |
| Zhou, L | 1 |
| Zhao, Y | 3 |
| Wang, J | 6 |
| Huang, L | 2 |
| Hu, K | 1 |
| Liu, H | 4 |
| Wang, H | 3 |
| Guo, Z | 1 |
| Song, Y | 1 |
| Huang, H | 4 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 1 |
| Zhou, X | 1 |
| Wang, B | 4 |
| Zhang, Q | 4 |
| Wu, X | 2 |
| Yao, Y | 3 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
| Nakano, R | 2 |
| Kubota, Y | 2 |
| Hara, M | 1 |
| Sunada, K | 1 |
| Hashimoto, K | 1 |
| Kajioka, J | 1 |
| Fujishima, A | 1 |
| Jiao, J | 3 |
| Gai, QY | 3 |
| Wang, W | 2 |
| Zang, YP | 2 |
| Niu, LL | 2 |
| Fu, YJ | 3 |
| Wang, X | 4 |
| Yao, LP | 1 |
| Qin, QP | 1 |
| Wang, ZY | 1 |
| Liu, J | 4 |
| Aleksic Sabo, V | 1 |
| Knezevic, P | 1 |
| Borges-Argáez, R | 1 |
| Chan-Balan, R | 1 |
| Cetina-Montejo, L | 1 |
| Ayora-Talavera, G | 1 |
| Sansores-Peraza, P | 1 |
| Gómez-Carballo, J | 1 |
| Cáceres-Farfán, M | 1 |
| Jang, J | 1 |
| Akin, D | 1 |
| Bashir, R | 1 |
| Yu, Z | 1 |
| Zhu, J | 2 |
| Jiang, H | 1 |
| He, C | 2 |
| Xiao, Z | 1 |
| Xu, J | 2 |
| Sun, Q | 1 |
| Han, D | 1 |
| Lei, H | 1 |
| Zhao, K | 2 |
| Zhu, L | 1 |
| Li, X | 4 |
| Fu, H | 2 |
| Wilson, BK | 1 |
| Step, DL | 1 |
| Maxwell, CL | 1 |
| Gifford, CA | 1 |
| Richards, CJ | 1 |
| Krehbiel, CR | 1 |
| Warner, JM | 1 |
| Doerr, AJ | 1 |
| Erickson, GE | 1 |
| Guretzky, JA | 1 |
| Rasby, RJ | 1 |
| Watson, AK | 1 |
| Klopfenstein, TJ | 1 |
| Sun, Y | 4 |
| Liu, Z | 3 |
| Pham, TD | 1 |
| Lee, BK | 1 |
| Yang, FC | 1 |
| Wu, KH | 1 |
| Lin, WP | 1 |
| Hu, MK | 1 |
| Lin, L | 3 |
| Shao, J | 1 |
| Sun, M | 1 |
| Xu, G | 1 |
| Zhang, X | 6 |
| Xu, N | 1 |
| Wang, R | 1 |
| Liu, S | 1 |
| He, H | 1 |
| Dong, X | 2 |
| Yang, M | 2 |
| Yang, Q | 1 |
| Duan, S | 1 |
| Yu, Y | 2 |
| Han, J | 2 |
| Zhang, C | 3 |
| Chen, L | 2 |
| Yang, X | 1 |
| Li, W | 3 |
| Wang, T | 2 |
| Campbell, DA | 1 |
| Gao, K | 1 |
| Zager, RA | 1 |
| Johnson, ACM | 1 |
| Guillem, A | 1 |
| Keyser, J | 1 |
| Singh, B | 1 |
| Steubl, D | 1 |
| Schneider, MP | 1 |
| Meiselbach, H | 1 |
| Nadal, J | 1 |
| Schmid, MC | 1 |
| Saritas, T | 1 |
| Krane, V | 1 |
| Sommerer, C | 1 |
| Baid-Agrawal, S | 1 |
| Voelkl, J | 1 |
| Kotsis, F | 1 |
| Köttgen, A | 1 |
| Eckardt, KU | 1 |
| Scherberich, JE | 1 |
| Li, H | 4 |
| Yao, L | 2 |
| Sun, L | 3 |
| Zhu, Z | 1 |
| Naren, N | 1 |
| Zhang, XX | 2 |
| Gentile, GL | 1 |
| Rupert, AS | 1 |
| Carrasco, LI | 1 |
| Garcia, EM | 1 |
| Kumar, NG | 1 |
| Walsh, SW | 1 |
| Jefferson, KK | 1 |
| Guest, RL | 1 |
| Samé Guerra, D | 1 |
| Wissler, M | 1 |
| Grimm, J | 1 |
| Silhavy, TJ | 1 |
| Lee, JH | 2 |
| Yoo, JS | 1 |
| Kim, Y | 1 |
| Kim, JS | 2 |
| Lee, EJ | 1 |
| Roe, JH | 1 |
| Delorme, M | 1 |
| Bouchard, PA | 1 |
| Simon, M | 1 |
| Simard, S | 1 |
| Lellouche, F | 1 |
| D'Urzo, KA | 1 |
| Mok, F | 1 |
| D'Urzo, AD | 1 |
| Koneru, B | 1 |
| Lopez, G | 1 |
| Farooqi, A | 1 |
| Conkrite, KL | 1 |
| Nguyen, TH | 1 |
| Macha, SJ | 1 |
| Modi, A | 1 |
| Rokita, JL | 1 |
| Urias, E | 1 |
| Hindle, A | 1 |
| Davidson, H | 1 |
| Mccoy, K | 1 |
| Nance, J | 1 |
| Yazdani, V | 1 |
| Irwin, MS | 1 |
| Yang, S | 1 |
| Wheeler, DA | 1 |
| Maris, JM | 1 |
| Diskin, SJ | 1 |
| Reynolds, CP | 1 |
| Abhilash, L | 1 |
| Kalliyil, A | 1 |
| Sheeba, V | 1 |
| Hartley, AM | 2 |
| Meunier, B | 2 |
| Pinotsis, N | 1 |
| Maréchal, A | 2 |
| Xu, JY | 1 |
| Genko, N | 1 |
| Haraux, F | 1 |
| Rich, PR | 1 |
| Kamalanathan, M | 1 |
| Doyle, SM | 1 |
| Xu, C | 1 |
| Achberger, AM | 1 |
| Wade, TL | 1 |
| Schwehr, K | 1 |
| Santschi, PH | 1 |
| Sylvan, JB | 1 |
| Quigg, A | 1 |
| Leong, W | 1 |
| Xu, W | 2 |
| Gao, S | 1 |
| Zhai, X | 1 |
| Wang, C | 2 |
| Gilson, E | 1 |
| Ye, J | 1 |
| Lu, Y | 1 |
| Yan, R | 1 |
| Zhang, Y | 6 |
| Hu, Z | 1 |
| You, Q | 1 |
| Cai, Q | 1 |
| Yang, D | 1 |
| Gu, S | 1 |
| Dai, H | 1 |
| Zhao, X | 1 |
| Gui, C | 1 |
| Gui, J | 1 |
| Wu, PK | 1 |
| Hong, SK | 1 |
| Starenki, D | 1 |
| Oshima, K | 1 |
| Shao, H | 1 |
| Gestwicki, JE | 1 |
| Tsai, S | 1 |
| Park, JI | 1 |
| Wang, Y | 7 |
| Zhao, R | 1 |
| Gu, Z | 1 |
| Dong, C | 2 |
| Guo, G | 1 |
| Li, L | 4 |
| Barrett, HE | 1 |
| Meester, EJ | 1 |
| van Gaalen, K | 1 |
| van der Heiden, K | 1 |
| Krenning, BJ | 1 |
| Beekman, FJ | 1 |
| de Blois, E | 1 |
| de Swart, J | 1 |
| Verhagen, HJ | 1 |
| Maina, T | 1 |
| Nock, BA | 1 |
| Norenberg, JP | 1 |
| de Jong, M | 1 |
| Gijsen, FJH | 1 |
| Bernsen, MR | 1 |
| Martínez-Milla, J | 1 |
| Galán-Arriola, C | 1 |
| Carnero, M | 1 |
| Cobiella, J | 1 |
| Pérez-Camargo, D | 1 |
| Bautista-Hernández, V | 1 |
| Rigol, M | 1 |
| Solanes, N | 1 |
| Villena-Gutierrez, R | 1 |
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| Mateo, J | 1 |
| Vilchez-Tschischke, JP | 1 |
| Salinas, B | 1 |
| Cussó, L | 1 |
| López, GJ | 1 |
| Fuster, V | 1 |
| Desco, M | 1 |
| Sanchez-González, J | 1 |
| Ibanez, B | 1 |
| van den Berg, P | 1 |
| Schweitzer, DH | 1 |
| van Haard, PMM | 1 |
| Geusens, PP | 1 |
| van den Bergh, JP | 1 |
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| Huang, X | 2 |
| Xu, H | 2 |
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| Lin, Z | 1 |
| Salem, HF | 1 |
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| Domiciano, D | 1 |
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| Chalfun-Júnior, A | 1 |
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| Jiang, J | 2 |
| Li, J | 7 |
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| Liu, Y | 7 |
| Song, J | 1 |
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| Gallo, A | 1 |
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| Ceron, E | 1 |
| Covino, M | 1 |
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| Pocino, K | 1 |
| Ianiro, G | 1 |
| Cammarota, G | 1 |
| Gasbarrini, A | 1 |
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| Somasundar, Y | 1 |
| Lu, IC | 1 |
| Mills, MR | 1 |
| Qian, LY | 1 |
| Olivares, X | 1 |
| Ryabov, AD | 1 |
| Collins, TJ | 1 |
| Zhao, L | 1 |
| Doddipatla, S | 1 |
| Thomas, AM | 1 |
| Nikolayev, AA | 1 |
| Galimova, GR | 1 |
| Azyazov, VN | 1 |
| Mebel, AM | 1 |
| Kaiser, RI | 1 |
| Guo, S | 1 |
| Yang, P | 1 |
| Yu, X | 2 |
| Wu, Y | 2 |
| Zhang, H | 1 |
| Yu, B | 3 |
| Han, B | 1 |
| George, MW | 1 |
| Moor, MB | 1 |
| Bonny, O | 1 |
| Langenberg, E | 1 |
| Paik, H | 1 |
| Smith, EH | 1 |
| Nair, HP | 1 |
| Hanke, I | 1 |
| Ganschow, S | 1 |
| Catalan, G | 1 |
| Domingo, N | 1 |
| Schlom, DG | 1 |
| Assefa, MK | 1 |
| Wu, G | 2 |
| Hayton, TW | 1 |
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| Enikeev, D | 1 |
| Netsch, C | 1 |
| Gross, AJ | 1 |
| Laukhtina, E | 1 |
| Glybochko, P | 1 |
| Rapoport, L | 1 |
| Herrmann, TRW | 1 |
| Taratkin, M | 1 |
| Dai, W | 1 |
| Shi, J | 2 |
| Carreno, J | 1 |
| Kloner, RA | 1 |
| Pickersgill, NA | 1 |
| Vetter, JM | 1 |
| Kim, EH | 1 |
| Cope, SJ | 1 |
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| Venkatesh, R | 1 |
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| Saad, NES | 1 |
| Bhayani, SB | 1 |
| Figenshau, RS | 1 |
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| Lei, P | 1 |
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| Ford, CR | 1 |
| Kleppinger, EL | 1 |
| Helms, K | 1 |
| Bush, AA | 1 |
| Luna-Abanto, J | 1 |
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| Laura Martinez, J | 1 |
| Álvarez Larraondo, M | 1 |
| Villoslada Terrones, V | 1 |
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| Simundic, AM | 1 |
| Chogtu, B | 1 |
| Ommurugan, B | 1 |
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| Benidir, M | 1 |
| El Massoudi, S | 1 |
| El Ghadraoui, L | 1 |
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| Benjelloun, M | 1 |
| Errachidi, F | 1 |
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| Law, AD | 1 |
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| Giebultowicz, JM | 1 |
| Kretzschmar, D | 1 |
| Salonurmi, T | 1 |
| Nabil, H | 1 |
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| Hyötyläinen, T | 1 |
| Hautajärvi, H | 1 |
| Savolainen, MJ | 1 |
| Tolonen, A | 1 |
| Orešič, M | 1 |
| Känsäkoski, P | 1 |
| Rysä, J | 1 |
| Hakkola, J | 1 |
| Hukkanen, J | 1 |
| Zhu, N | 1 |
| Li, Y | 4 |
| Du, Q | 1 |
| Hao, P | 1 |
| Cao, X | 1 |
| Li, CX | 1 |
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| Luo, XM | 1 |
| Feng, JX | 1 |
| Gonzalez-Cotto, M | 1 |
| Guo, L | 1 |
| Karwan, M | 1 |
| Sen, SK | 1 |
| Barb, J | 1 |
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| Palmieri, EM | 1 |
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| Kolodgie, FD | 1 |
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| Biesecker, LG | 1 |
| McVicar, DW | 1 |
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| Deng, Z | 1 |
| Xie, Y | 2 |
| Tang, J | 3 |
| Chen, Z | 2 |
| Luo, W | 1 |
| Xiong, D | 1 |
| Zhao, D | 1 |
| Fang, J | 1 |
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| Niu, PP | 1 |
| Song, B | 1 |
| Xu, YM | 1 |
| Zhang, Z | 2 |
| Qiu, N | 1 |
| Yin, J | 1 |
| Zhang, J | 3 |
| Guo, W | 1 |
| Liu, M | 2 |
| Liu, T | 3 |
| Chen, D | 5 |
| Luo, K | 1 |
| He, Z | 2 |
| Zheng, G | 1 |
| Xu, F | 1 |
| Sun, W | 1 |
| Yin, F | 1 |
| van Hest, JCM | 1 |
| Du, L | 2 |
| Shi, X | 1 |
| Kang, S | 1 |
| Duan, W | 1 |
| Zhang, S | 2 |
| Feng, J | 2 |
| Qi, N | 1 |
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| Ren, H | 1 |
| Shang, Q | 1 |
| Zhao, W | 2 |
| Yang, Z | 2 |
| Jiang, X | 2 |
| Alame, M | 1 |
| Cornillot, E | 1 |
| Cacheux, V | 1 |
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| De Oliveira, L | 1 |
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| Delvenne, P | 1 |
| Turtoi, E | 1 |
| Cabello-Aguilar, S | 1 |
| Nishiyama, M | 1 |
| Turtoi, A | 1 |
| Costes-Martineau, V | 1 |
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| Guo, Q | 1 |
| Quan, M | 1 |
| Dong, J | 1 |
| Bai, J | 1 |
| Han, R | 1 |
| Cai, Y | 1 |
| Lv, YQ | 1 |
| Chen, Q | 1 |
| Lyu, HD | 1 |
| Deng, L | 1 |
| Zhou, D | 1 |
| Xiao, X | 1 |
| De Langhe, S | 1 |
| Billadeau, DD | 1 |
| Lou, Z | 1 |
| Zhang, JS | 1 |
| Xue, Z | 1 |
| Shen, XD | 1 |
| Gao, F | 1 |
| Busuttil, RW | 1 |
| Kupiec-Weglinski, JW | 1 |
| Ji, H | 1 |
| Otano, I | 1 |
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| Ochoa, MC | 1 |
| Migueliz, I | 1 |
| Molina, C | 1 |
| Azpilikueta, A | 1 |
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| Berraondo, P | 1 |
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| Yu, Q | 1 |
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| Liu, W | 1 |
| Chen, W | 1 |
| Yin, Y | 1 |
| Li, CW | 1 |
| Hsu, JL | 1 |
| Zhou, Q | 1 |
| Hu, B | 1 |
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| Crawford, JH | 2 |
| Chacko, BK | 1 |
| Kevil, CG | 1 |
| Narendra, M | 1 |
| Bhatracharyulu, NC | 1 |
| Padmavathi, P | 1 |
| Varadacharyulu, NC | 1 |
| Dodge, JT | 1 |
| Cohen, G | 1 |
| Kayden, HJ | 1 |
| Phillips, GB | 1 |
| Singelmann, E | 1 |
| Wetzel, E | 1 |
| Adler, G | 1 |
| Steffen, C | 1 |
| Smith, RC | 1 |
| Nunn, V | 1 |
| Ring, A | 1 |
| Braun, JS | 1 |
| Nizet, V | 1 |
| Stremmel, W | 1 |
| Shenep, JL | 1 |
| Berger, U | 1 |
| Pervanidis, A | 1 |
| Baird, JK | 1 |
| Davidson, DE | 1 |
| Decker-Jackson, JE | 1 |
| Hauschild, AH | 1 |
| Hilsheimer, R | 1 |
| Griffith, DW | 1 |
| Smith, RP | 2 |
| Kruszyna, H | 1 |
| Pedersen, KB | 1 |
| Osborne, CK | 1 |
| Carolla, R | 1 |
| Jefferson, D | 1 |
| Mengel, CE | 1 |
| Pearlman, FC | 1 |
| Lee, RT | 1 |
| Tudhope, GR | 1 |
| Leece, SP | 1 |
| Jung, F | 1 |
| Kahl, R | 1 |
| D'Elia, R | 1 |
| McClatchy, JK | 1 |
| Rosenblum, ED | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Red Cell Storage Duration Study[NCT00991341] | Phase 3 | 1,481 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| A Safety and Efficacy Evaluation of Sodium Nitrite Injection for the Treatment of Vaso-Occlusive Crisis Associated With Sickle Cell Disease[NCT01033227] | Phase 1/Phase 2 | 5 participants (Actual) | Interventional | 2009-12-31 | Terminated (stopped due to Low enrollment) | ||
| Phase I/II Study of Simvastatin (Zocor) Therapy in Sickle Cell Disease[NCT00508027] | Phase 1/Phase 2 | 42 participants (Actual) | Interventional | 2007-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Subjects were randomized for RECESS no earlier than one calendar day before the planned date of surgery, and were followed for all-cause mortality until post-operative Day 28, death, or study withdrawal, whichever occurred first. In some cases the surgery was postponed after randomization had already occurred. If surgery did not occur within 30 days after randomization, the subject ended the study and was not considered evaluable. If surgery did occur within 30 days after randomization, and the subject received at least one RBC transfusion between randomization and 96 hours after the end of surgery, the subject was considered evaluable. Therefore, in a few evaluable subjects, post-operative Day 28 could be nearly two months after the date of randomization. The times in the time-to-event analysis started at randomization. (NCT00991341)
Timeframe: 28 days post-surgery
| Intervention | participants with event (Number) |
|---|---|
| Shorter-storage Red Blood Cell Units | 23 |
| Longer-storage Red Blood Cell Units | 29 |
(NCT00991341)
Timeframe: 48 hours post-operation through day 28, hospital discharge, or death, whichever occurs first
| Intervention | participants with event (Number) |
|---|---|
| Shorter-storage Red Blood Cell Units | 68 |
| Longer-storage Red Blood Cell Units | 80 |
(NCT00991341)
Timeframe: Through post-operative day 7, hospital discharge, or death, whichever occurs first
| Intervention | mg/dL (Mean) |
|---|---|
| Shorter-storage Red Blood Cell Units | 0.85 |
| Longer-storage Red Blood Cell Units | 1.49 |
The arterial lactate levels were adjusted to make them comparable to venous lactate levels. (NCT00991341)
Timeframe: Through post-operative day 7, hospital discharge, or death, whichever occurs first
| Intervention | mmol/L (Mean) |
|---|---|
| Shorter-storage Red Blood Cell Units | 2.30 |
| Longer-storage Red Blood Cell Units | 2.92 |
The follow-up MODS used to calculate 28-day ΔMODS from pre-op baseline was based on the worst value of each component of MODS observed through post-op day 28, hospital discharge, or death, whichever occurred first, even if a subject's worst values for different components occurred on different dates. Subjects who died during this time period were assigned the worst possible follow-up MODS score, 24 points, and each component of MODS was set at 4, which is the worst score. If a subject did not die during this time period but had at least one day where the Glasgow Coma Score couldn't be scored[subject sedated; neurologic function not normal by pre-op history (prior stroke, tumor or trauma sequelae, cognitively challenged, behavioral disorder, etc.) or intra-op history, but currently unable to assess because of sedation], then a post-op MODS score was set to missing and a 28-day ΔMODS was not computed. The total MODS score ranges from 0 (best possible) to 24 points (worst possible). (NCT00991341)
Timeframe: Through 28 days post-surgery, hospital discharge, or death, whichever occurs first
| Intervention | MOD score points (Mean) |
|---|---|
| Shorter-storage Red Blood Cell Units | 8.74 |
| Longer-storage Red Blood Cell Units | 9.07 |
(NCT00991341)
Timeframe: Through post-operative day 7, hospital discharge, or death, whichever occurs first
| Intervention | mg/dL (Mean) |
|---|---|
| Shorter-storage Red Blood Cell Units | 0.35 |
| Longer-storage Red Blood Cell Units | 0.35 |
(NCT00991341)
Timeframe: Through post-operative day 7, hospital discharge, or death, whichever occurs first
| Intervention | ng/mL (Mean) |
|---|---|
| Shorter-storage Red Blood Cell Units | 15.82 |
| Longer-storage Red Blood Cell Units | 14.06 |
(NCT00991341)
Timeframe: Through post-operative day 7, hospital discharge, or death, whichever occurs first
| Intervention | participants with event (Number) |
|---|---|
| Shorter-storage Red Blood Cell Units | 206 |
| Longer-storage Red Blood Cell Units | 230 |
(NCT00991341)
Timeframe: Through post-operative day 7, hospital discharge, or death, whichever occurs first
| Intervention | participants with event (Number) |
|---|---|
| Shorter-storage Red Blood Cell Units | 91 |
| Longer-storage Red Blood Cell Units | 87 |
(NCT00991341)
Timeframe: Through post-operative day 7, hospital discharge, or death, whichever occurs first
| Intervention | participants with event (Number) |
|---|---|
| Shorter-storage Red Blood Cell Units | 62 |
| Longer-storage Red Blood Cell Units | 75 |
(NCT00991341)
Timeframe: Through post-op day 28
| Intervention | days (Mean) |
|---|---|
| Shorter-storage Red Blood Cell Units | 25.38 |
| Longer-storage Red Blood Cell Units | 25.17 |
Subjects were randomized for RECESS no earlier than one calendar day before the planned date of surgery, and were followed until post-operative Day 28, death, or study withdrawal, whichever occurred first. In some cases the surgery was postponed after randomization had already occurred. If surgery did not occur within 30 days after randomization, the subject ended the study and was not considered evaluable. If surgery did occur within 30 days after randomization, and the subject received at least one RBC transfusion between randomization and 96 hours after the end of surgery, the subject was considered evaluable. Therefore, in a few evaluable subjects, post-operative Day 28 could be nearly two months after the date of randomization. The times in the time-to-event analyses are from randomization to first post-operative bowel movement. (NCT00991341)
Timeframe: Through post-operative day 28, hospital discharge, or death, whichever occurs first
| Intervention | days (Mean) |
|---|---|
| Shorter-storage Red Blood Cell Units | 5.89 |
| Longer-storage Red Blood Cell Units | 6.62 |
Subjects were randomized for RECESS no earlier than one calendar day before the planned date of surgery, and were followed until post-operative Day 28, death, or study withdrawal, whichever occurred first. In some cases the surgery was postponed after randomization had already occurred. If surgery did not occur within 30 days after randomization, the subject ended the study and was not considered evaluable. If surgery did occur within 30 days after randomization, and the subject received at least one RBC transfusion between randomization and 96 hours after the end of surgery, the subject was considered evaluable. Therefore, in a few evaluable subjects, post-operative Day 28 could be nearly two months after the date of randomization. The times in the time-to-event analyses are from randomization to first post-operative solid food. (NCT00991341)
Timeframe: Through post-operative day 28, hospital discharge, or death, whichever occurs first
| Intervention | days (Mean) |
|---|---|
| Shorter-storage Red Blood Cell Units | 5.73 |
| Longer-storage Red Blood Cell Units | 6.18 |
The follow-up MODS used to calculate 7-day ΔMODS from pre-op baseline was based on the worst value of each component of MODS observed through post-op day 7, hospital discharge, or death, whichever occurred first, even if a subject's worst values for different components occurred on different dates. Subjects who died during this time period were assigned the worst possible follow-up MODS score, 24 points, and each component of MODS was set at 4, which is the worst score. If a subject did not die during this time period but had at least one day where the Glasgow Coma Score couldn't be scored [subject sedated; neurologic function not normal by pre-op history (prior stroke, tumor or trauma sequelae, cognitively challenged, behavioral disorder, etc.) or intra-op history, but currently unable to assess because of sedation], then a post-op MODS score was set to missing and a 7-day ΔMODS was not computed. The total MODS score ranges from 0 (best possible) to 24 points (worst possible). (NCT00991341)
Timeframe: Through post-operative day 7, hospital discharge, or death, whichever occurs first
| Intervention | MOD score points (Mean) |
|---|---|
| Shorter-storage Red Blood Cell Units | 8.49 |
| Longer-storage Red Blood Cell Units | 8.66 |
Because some subjects may experience multiple periods of ventilator use, the total duration that they were on a ventilator was compared between the two groups. (NCT00991341)
Timeframe: Through post-operative day 28, hospital discharge, or death, whichever occurs first
| Intervention | days (Mean) |
|---|---|
| Shorter-storage Red Blood Cell Units | 2.7 |
| Longer-storage Red Blood Cell Units | 2.8 |
The primary end points will be to determine if a) a 48-hour sodium nitrite infusion is tolerated without a decrease in mean arterial blood pressure by 15mmHg for greater than 2 hours or development of methemoglobin greater than 5% and b) a 48-hour sodium nitrite infusion is safe as determined by monitoring for adverse events (NCT01033227)
Timeframe: 48 hours from start of infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| No Drug | 3 |
| Sodium Nitrite Injection, USP | 2 |
Change in plasma hemoglobin (Hb) level after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | gm/dL (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | -0.2 |
| Simvastatin, Dose Level 2 | 0.1 |
| Simvastatin, Dose Level 3 | -0.4 |
Change in plasma high sensitivity C-reactive protein levels in subjects treated with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | mg/L (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | -7.7 |
| Simvastatin, Dose Level 2 | -3.6 |
Change in plasma IL-6 level after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | pg/mL (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | -0.6 |
| Simvastatin, Dose Level 2 | -0.3 |
Measurements of the levels of plasma nitric oxide metabolites (NOx), high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), vascular cell adhesion molecule-1 (VCAM-1), tissue factor (TF) and vascular endothelial growth factor (VEGF)were performed before and after simvastatin treatment. Changes in mean plasma biomarker levels were assessed for each dose level; however, dose level 3 results were not analyzed, as only 2 subjects were enrolled in this dose group. (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | micromolar (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | 7 |
| Simvastatin, Dose Level 2 | 19.7 |
Change in plasma tissue factor (TF) levels after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | pg/mL (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | -9 |
| Simvastatin, Dose Level 2 | -36 |
Change in plasma vascular cellular adhesion molecule-1 levels after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | ng/mL (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | -44 |
| Simvastatin, Dose Level 2 | -86 |
Change in plasma vascular endothelial adhesion molecule-1 levels after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | pg/mL (Mean) |
|---|---|
| Dose Level 1 | -164 |
| Dose Level 2 | -30 |
Change in serum alanine transaminase (ALT) after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | U/L (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | 4 |
| Simvastatin, Dose Level 2 | 3 |
| Simvastatin, Dose Level 3 | -3 |
Change in serum creatine kinase (CK) levels after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | U/L (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | 57 |
| Simvastatin, Dose Level 2 | 20 |
| Simvastatin, Dose Level 3 | 62 |
Change in serum creatinine (Cr) levels after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | mg/dL (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | 0.03 |
| Simvastatin, Dose Level 2 | 0.04 |
| Simvastatin, Dose Level 3 | -0.1 |
Change in serum total cholesterol level after treatment with simvastatin (NCT00508027)
Timeframe: Baseline, 21 days
| Intervention | mg/dL (Mean) |
|---|---|
| Simvastatin, Dose Level 1 | -16 |
| Simvastatin, Dose Level 2 | -18 |
| Simvastatin, Dose Level 3 | -18 |
3 reviews available for nitrites and Hemolysis
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation.
Topics: Anemia, Hemolytic; Biological Availability; Blood Circulation; Erythrocyte Membrane; Hemoglobins; He | 2004 |
The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation.
Topics: Anemia, Hemolytic; Biological Availability; Blood Circulation; Erythrocyte Membrane; Hemoglobins; He | 2004 |
The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation.
Topics: Anemia, Hemolytic; Biological Availability; Blood Circulation; Erythrocyte Membrane; Hemoglobins; He | 2004 |
The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation.
Topics: Anemia, Hemolytic; Biological Availability; Blood Circulation; Erythrocyte Membrane; Hemoglobins; He | 2004 |
The red blood cell and vascular function in health and disease.
Topics: Adenosine Triphosphate; Animals; Cell Adhesion; Cell-Free System; Endothelium, Vascular; Erythrocyte | 2004 |
2 trials available for nitrites and Hemolysis
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers.
Topics: Adult; Blood Preservation; Blood Transfusion, Autologous; Cross-Over Studies; Female; Hemolysis; Hum | 2012 |
35 other studies available for nitrites and Hemolysis
| Article | Year |
|---|---|
Garcinielliptone FC: Selective anti-amastigote and immunomodulatory effects on macrophages infected by Leishmania amazonensis.
Topics: Animals; Antiprotozoal Agents; Cell Survival; Cells, Cultured; Erythrocytes; Female; Hemolysis; Immu | 2020 |
Effects of isopentyl ferulate on oxidative stress biomarkers and a possible GABAergic anxiolytic-like trait in Swiss mice.
Topics: Animals; Anti-Anxiety Agents; Antioxidants; Artemia; Ascorbic Acid; Behavior, Animal; Biomarkers; Ca | 2018 |
[Magnetic-laser influence on the system of nitric oxide and contractile activity of smooth muscles of rat aorta under hypertension].
Topics: Acetylcholine; Animals; Aorta; Erythrocytes; Hemoglobins; Hemolysis; Hypertension; Lasers; Low-Level | 2012 |
Erythrocyte nitric oxide synthase as a surrogate marker for mercury-induced vascular damage: the modulatory effects of naringin.
Topics: Antioxidants; Arginine; Biomarkers; Environmental Pollutants; Erythrocytes; Flavanones; Glucosephosp | 2014 |
Increased erythrocytes by-products of arginine catabolism are associated with hyperglycemia and could be involved in the pathogenesis of type 2 diabetes mellitus.
Topics: Adult; Aged; Arginine; Blood Glucose; Carbon Isotopes; Case-Control Studies; Citrulline; Diabetes Me | 2013 |
Predicting storage-dependent damage to red blood cells using nitrite oxidation kinetics, peroxiredoxin-2 oxidation, and hemoglobin and free heme measurements.
Topics: Blood Preservation; Erythrocytes; Heme; Hemoglobins; Hemolysis; Humans; Kinetics; Nitrites; Oxidatio | 2015 |
The Impact of Surgery and Stored Red Blood Cell Transfusions on Nitric Oxide Homeostasis.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Blood Loss, Surgical; Down-Regulation; Erythrocyte Trans | 2016 |
Bergenin from Peltophorum dubium: Isolation, Characterization, and Antioxidant Activities in Non-Biological Systems and Erythrocytes.
Topics: Animals; Antioxidants; Benzopyrans; Benzothiazoles; Biphenyl Compounds; Electron Transport; Erythroc | 2017 |
Antimicrobial and anti-inflammatory activities of designed antimicrobial peptide P18 analogues.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antimicrobial Cationic Pept | 2008 |
Plant secondary metabolites.
Topics: Alkaloids; Biological Products; Calibration; Canavanine; Chemistry Techniques, Analytical; Chlorogen | 2007 |
Inhaled nitrite reverses hemolysis-induced pulmonary vasoconstriction in newborn lambs without blood participation.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Hemoglobins; Hemolysis; Hypertension, Pulmona | 2011 |
Protective effect of pravastatin against mercury induced vascular cells damage: erythrocytes as surrogate markers.
Topics: Adult; Antioxidants; Catalase; Cells, Cultured; Environmental Pollutants; Erythrocytes; Glutathione | 2012 |
Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin.
Topics: Animals; Blood Platelets; Blood Pressure; Dogs; Erythrocytes; Heart Rate; Hemolysis; Leukocytes; Met | 2012 |
Premature atherosclerosis in children with β-thalassemia major.
Topics: Adolescent; Age of Onset; Atherosclerosis; beta-Thalassemia; Biomarkers; Blood Glucose; Carotid Inti | 2012 |
Oxidative stress-induced posttranslational modifications of human hemoglobin in erythrocytes.
Topics: Aldehydes; Amino Acid Sequence; Cells, Cultured; Dose-Response Relationship, Radiation; Erythrocyte | 2013 |
Hypochlorous acid-induced oxidative damage of human red blood cells: effects of tert-butyl hydroperoxide and nitrite on the HOCl reaction with erythrocytes.
Topics: Acetylcholinesterase; Drug Synergism; Erythrocyte Membrane; Erythrocytes; Glutathione; Hemolysis; Hu | 2002 |
Age-related increase in resistance to acute Trypanosoma cruzi infection in rats is associated with an appropriate antibody response.
Topics: Age Factors; Animals; Antibodies, Protozoan; Chagas Disease; Hemolysis; Immunity, Innate; Interferon | 2003 |
[The effects of nitrite on adenine compounds in the human blood hemolysates].
Topics: Adenine; Hemolysis; Humans; Nitrites | 1962 |
Prallethrin induced biochemical changes in erythrocyte membrane and red cell osmotic haemolysis in human volunteers.
Topics: Adult; Cholesterol; Erythrocyte Membrane; Hemolysis; Humans; Male; Membrane Lipids; Middle Aged; Nit | 2007 |
Peroxidative hemolysis of red blood cells from patients with abetalipoproteinemia (acanthocytosis).
Topics: Abetalipoproteinemia; Adult; Animals; Barbiturates; Carbon Monoxide; Chromatography, Gas; Chromatogr | 1967 |
Erythrocyte membrane alterations as the basis of chlorate toxicity.
Topics: Chlorates; Electrophoresis, Polyacrylamide Gel; Erythrocyte Membrane; Glutathione; Hemolysis; Humans | 1984 |
Prevention by 3-N-ribosyluric acid of the oxidation of bovine hemoglobin by sodium nitrite.
Topics: Animals; Ascorbic Acid; Cattle; Erythrocytes; Glutathione; Hemolysis; Hydrogen Peroxide; In Vitro Te | 1984 |
Group B streptococcal beta-hemolysin induces nitric oxide production in murine macrophages.
Topics: Animals; Bacterial Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Induction; He | 2000 |
Differentiation of Gemella haemolysans (Thjøtta and Bøe 1938) Berger 1960, from Streptococcus morbillorum (Prevot 1933) Holdeman and Moore 1974.
Topics: Antigens, Bacterial; Epitopes; Hemolysis; Nitrites; Oxidation-Reduction; Streptococcaceae; Streptoco | 1986 |
Oxidative activity of hydroxylated primaquine analogs. Non-toxicity to glucose-6-phosphate dehydrogenase-deficient human red blood cells in vitro.
Topics: Adenosine Triphosphate; Adult; Aminoquinolines; Erythrocytes; Glucosephosphate Dehydrogenase Deficie | 1986 |
Enumeration of fecal Clostridium perfringens spores in egg yolk-free tryptose-sulfite-cycloserine agar.
Topics: Agar; Anaerobiosis; Bacteriological Techniques; Cell Count; Clostridium; Clostridium perfringens; Cu | 1974 |
Nitroprusside produces cyanide poisoning via reaction with hemoglobin.
Topics: Animals; Cyanides; Erythrocytes; Female; Ferricyanides; Hemoglobins; Hemolysis; Humans; Lethal Dose | 1974 |
Isolation and description of a haemolytic species of Neisseria (N. ovis) from cattle with infectious keratoconjunctivitis.
Topics: Animals; Catalase; Cattle; Cattle Diseases; Disaccharides; DNA; Drug Resistance, Microbial; Hemolysi | 1972 |
Effect of methemoglobin on in vivo RBC lipid peroxidation.
Topics: Animals; Catalase; Erythrocytes; Female; Hemoglobinuria; Hemolysis; Hyperbaric Oxygenation; Lipid Me | 1973 |
Detection and measurement of total bilirubin in serum, with use of surfactants as solubilizing agents.
Topics: Azo Compounds; Benzoates; Bilirubin; Caffeine; Evaluation Studies as Topic; Hemoglobins; Hemolysis; | 1974 |
Red-cell catalase and the production of methaemoglobin, Heinz bodies and changes in osmotic fragility due to drugs.
Topics: Aniline Compounds; Ascorbic Acid; Azides; Blood Glucose; Catalase; Chlorates; Erythrocytes; Glucosep | 1971 |
Cobalt salts: effects in cyanide and sulfide poisoning and on methemoglobinemia.
Topics: Animals; Chlorides; Cobalt; Cyanides; Erythrocytes; Female; Hemolysis; Methemoglobin; Methemoglobine | 1969 |
[On the reaction between homoglobin and sodium nitrite].
Topics: Animals; Catalase; Fluorides; Hemoglobins; Hemolysis; Humans; Hydrogen Peroxide; Hydrogen-Ion Concen | 1967 |
[Oxidative hemolysis in the newborn. 3. On the sensitivity of hemoglobin to different oxidizing agents].
Topics: Hemoglobins; Hemolysis; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methemoglobin; Methylene | 1968 |
Biological properties of alpha-toxin mutants of Staphylococcus aureus.
Topics: Antibodies; Coagulase; Dermatitis, Contact; Erythrocytes; Hemolysis; Injections, Intraperitoneal; Mu | 1966 |