nitrites has been researched along with HbS Disease in 20 studies
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydroxyurea (HU) has been suggested to act as a nitric oxide (NO) donor in sickle cell anemia (SCA)." | 2.87 | Hydroxyurea therapy modulates sickle cell anemia red blood cell physiology: Impact on RBC deformability, oxidative stress, nitrite levels and nitric oxide synthase signalling pathway. ( Bloch, W; Cannas, G; Collins, B; Connes, P; Fort, R; Gauthier, A; Grau, M; Guillot, N; Hot, A; Joly, P; Martin, C; Nader, E; Poutrel, S; Renoux, C; Romana, M; Thevis, M; Walpurgis, K, 2018) |
| "Hydroxyurea is a relatively new treatment for sickle cell disease." | 2.42 | Nitric oxide production from hydroxyurea. ( King, SB, 2004) |
| "The hypothesis of decreased nitric oxide (NO) bioavailability in sickle cell disease (SCD) proposes that multiple factors leading to decreased NO production and increased consumption contributes to vaso-occlusion, pulmonary hypertension, and pain." | 1.56 | Sickle cell disease subjects and mouse models have elevated nitrite and cGMP levels in blood compartments. ( Almeida, LEF; Darbari, DS; de Souza Batista, CM; Finkel, JC; Kamimura, S; Nettleton, MY; Quezado, ZMN; Smith, ML; Spornick, N; Wakim, P; Walek, E, 2020) |
| "Sickle cell disease is caused by a mutant form of hemoglobin that polymerizes under hypoxic conditions, increasing rigidity, fragility, calcium influx-mediated dehydration, and adhesivity of red blood cells." | 1.46 | Potential therapeutic action of nitrite in sickle cell disease. ( Alexander-Miller, MA; Basu, S; Bolden, CA; Buechler, NL; Caudell, DL; Gladwin, MT; Jailwala, A; Kim, HW; Kim-Shapiro, DB; Ostrowski, D; Perlegas, A; Rahbar, E; Vachharajani, V; Wajih, N, 2017) |
| "In Brazil, sickle cell anemia (SCA) is one of the most common genetic disorders." | 1.38 | Impact of β(S)-globin haplotypes on oxidative stress in patients with sickle cell anemia in steady state. ( Carvalho-dos Santos, BS; Cavalcante-Barbosa, M; da Silva-Rocha, LB; Dias-Elias, DB; Pinheiro-Gonçalves, R, 2012) |
| "A hemolysis-linked subphenotype of sickle cell disease (SCD), characterized by pulmonary hypertension, stroke, priapism and leg ulcers, is associated with decreased nitric oxide bioavailability and vasculopathy." | 1.35 | Novel small molecule therapeutics for sickle cell disease: nitric oxide, carbon monoxide, nitrite, and apolipoprotein A-I. ( Kato, GJ, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 13 (65.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Almeida, LEF | 3 |
| Smith, ML | 2 |
| Kamimura, S | 3 |
| Vogel, S | 1 |
| de Souza Batista, CM | 2 |
| Quezado, ZMN | 3 |
| Spornick, N | 1 |
| Nettleton, MY | 1 |
| Walek, E | 1 |
| Finkel, JC | 1 |
| Darbari, DS | 1 |
| Wakim, P | 2 |
| Wajih, N | 1 |
| Basu, S | 1 |
| Jailwala, A | 1 |
| Kim, HW | 1 |
| Ostrowski, D | 1 |
| Perlegas, A | 1 |
| Bolden, CA | 1 |
| Buechler, NL | 1 |
| Gladwin, MT | 2 |
| Caudell, DL | 1 |
| Rahbar, E | 1 |
| Alexander-Miller, MA | 1 |
| Vachharajani, V | 1 |
| Kim-Shapiro, DB | 1 |
| Wang, L | 1 |
| van der Meulen, JH | 1 |
| Nagaraju, K | 1 |
| Quezado, M | 1 |
| Nader, E | 1 |
| Grau, M | 1 |
| Fort, R | 1 |
| Collins, B | 1 |
| Cannas, G | 1 |
| Gauthier, A | 1 |
| Walpurgis, K | 1 |
| Martin, C | 1 |
| Bloch, W | 1 |
| Poutrel, S | 1 |
| Hot, A | 1 |
| Renoux, C | 1 |
| Thevis, M | 1 |
| Joly, P | 1 |
| Romana, M | 1 |
| Guillot, N | 1 |
| Connes, P | 1 |
| Nishank, SS | 1 |
| Singh, MP | 1 |
| Yadav, R | 1 |
| Gupta, RB | 1 |
| Gadge, VS | 1 |
| Gwal, A | 1 |
| Pitanga, TN | 2 |
| Oliveira, RR | 1 |
| Zanette, DL | 2 |
| Guarda, CC | 1 |
| Santiago, RP | 2 |
| Santana, SS | 2 |
| Nascimento, VML | 1 |
| Lima, JB | 1 |
| Carvalho, GQ | 1 |
| Maffili, VV | 1 |
| Carvalho, MOS | 1 |
| Alcântara, LCJ | 1 |
| Borges, VM | 2 |
| Goncalves, MS | 2 |
| da Guarda, CC | 1 |
| Kato, GJ | 1 |
| Sullivan, KJ | 2 |
| Kissoon, N | 2 |
| Sandler, E | 2 |
| Gauger, C | 1 |
| Froyen, M | 1 |
| Duckworth, L | 1 |
| Brown, M | 1 |
| Murphy, S | 1 |
| Rusanova, I | 1 |
| Escames, G | 1 |
| Cossio, G | 1 |
| de Borace, RG | 1 |
| Moreno, B | 1 |
| Chahboune, M | 1 |
| López, LC | 1 |
| Díez, T | 1 |
| Acuña-Castroviejo, D | 1 |
| Gonçalves, RP | 3 |
| Elias, DB | 2 |
| Magalhães, HI | 1 |
| de Souza, JH | 1 |
| Osei-Yeboah, CT | 1 |
| Rodrigues, O | 1 |
| Carvalho-dos Santos, BS | 1 |
| Dias-Elias, DB | 1 |
| da Silva-Rocha, LB | 1 |
| Cavalcante-Barbosa, M | 1 |
| Pinheiro-Gonçalves, R | 1 |
| Barbosa, MC | 2 |
| Rocha, LB | 1 |
| Dutra, LL | 1 |
| Silva, HF | 1 |
| Martins, AM | 1 |
| Dos Santos, TE | 1 |
| de Sousa, GF | 1 |
| King, SB | 1 |
| Nath, KA | 1 |
| Shah, V | 1 |
| Haggard, JJ | 1 |
| Croatt, AJ | 1 |
| Smith, LA | 1 |
| Hebbel, RP | 1 |
| Katusic, ZS | 1 |
| Duckworth, LJ | 1 |
| Freeman, B | 1 |
| Bayne, E | 1 |
| Sylvester, JE | 1 |
| Lima, JJ | 1 |
| Shelhamer, JH | 1 |
| Ognibene, FP | 1 |
| Pease-Fye, ME | 1 |
| Nichols, JS | 1 |
| Link, B | 1 |
| Patel, DB | 1 |
| Jankowski, MA | 1 |
| Pannell, LK | 1 |
| Schechter, AN | 1 |
| Rodgers, GP | 1 |
1 review available for nitrites and HbS Disease
| Article | Year |
|---|---|
Nitric oxide production from hydroxyurea.
Topics: Anemia, Sickle Cell; Free Radicals; Hemoglobins; Humans; Hydroxylamine; Hydroxyurea; Iron; Models, C | 2004 |
2 trials available for nitrites and HbS Disease
| Article | Year |
|---|---|
Hydroxyurea therapy modulates sickle cell anemia red blood cell physiology: Impact on RBC deformability, oxidative stress, nitrite levels and nitric oxide synthase signalling pathway.
Topics: Adult; Anemia, Sickle Cell; Erythrocyte Deformability; Erythrocytes; Female; Humans; Hydroxyurea; Ma | 2018 |
Effect of oral arginine supplementation on exhaled nitric oxide concentration in sickle cell anemia and acute chest syndrome.
Topics: Acute Chest Syndrome; Acute Disease; Administration, Oral; Adolescent; Anemia, Sickle Cell; Arginine | 2010 |
17 other studies available for nitrites and HbS Disease
| Article | Year |
|---|---|
Nitrite decreases sickle hemoglobin polymerization in vitro independently of methemoglobin formation.
Topics: Anemia, Sickle Cell; Animals; Hemoglobin, Sickle; Leukocytosis; Methemoglobin; Mice; Nitrites | 2023 |
Sickle cell disease subjects and mouse models have elevated nitrite and cGMP levels in blood compartments.
Topics: Adult; Anemia, Sickle Cell; Animals; Biological Availability; Cyclic GMP; Disease Models, Animal; Hu | 2020 |
Potential therapeutic action of nitrite in sickle cell disease.
Topics: Anemia, Sickle Cell; Animals; Blood Platelets; Calcium; Disease Models, Animal; Human Umbilical Vein | 2017 |
The role of nitrite in muscle function, susceptibility to contraction injury, and fatigability in sickle cell mice.
Topics: alpha-Globins; Anemia, Sickle Cell; Animals; Creatine Kinase; Female; Male; Methemoglobin; Mice, Tra | 2018 |
Endothelial nitric oxide synthase gene polymorphism is associated with sickle cell disease patients in India.
Topics: Adolescent; Alleles; Anemia, Sickle Cell; Case-Control Studies; Gene Frequency; Genetic Predispositi | 2013 |
Sickle red cells as danger signals on proinflammatory gene expression, leukotriene B4 and interleukin-1 beta production in peripheral blood mononuclear cell.
Topics: Adolescent; Anemia, Sickle Cell; Child; Child, Preschool; Erythrocytes, Abnormal; Female; Gene Expre | 2016 |
Heme changes HIF-α, eNOS and nitrite production in HUVECs after simvastatin, HU, and ascorbic acid therapies.
Topics: Anemia, Sickle Cell; Ascorbic Acid; Cells, Cultured; Dose-Response Relationship, Drug; Heme; Human U | 2016 |
Novel small molecule therapeutics for sickle cell disease: nitric oxide, carbon monoxide, nitrite, and apolipoprotein A-I.
Topics: Analgesics; Anemia, Sickle Cell; Apolipoprotein A-I; Carbon Monoxide; Clinical Trials as Topic; Cycl | 2008 |
Oxidative stress status, clinical outcome, and β-globin gene cluster haplotypes in pediatric patients with sickle cell disease.
Topics: Adolescent; Anemia, Sickle Cell; beta-Globins; Child; Child, Preschool; Female; Fetal Hemoglobin; Gl | 2010 |
Study of correlation of nitrite levels with malonaldehyde and the prognosis of patients with sickle cell disease on hydroxyurea, Ceará-Brazil.
Topics: Adult; Anemia, Sickle Cell; Blood Transfusion; Brazil; Cohort Studies; Female; Humans; Hydroxyurea; | 2011 |
Renal status of children with sickle cell disease in Accra, Ghana.
Topics: Age Factors; Anemia, Sickle Cell; Case-Control Studies; Child; Child, Preschool; Cross-Sectional Stu | 2011 |
Impact of β(S)-globin haplotypes on oxidative stress in patients with sickle cell anemia in steady state.
Topics: Adult; Aged; Anemia, Sickle Cell; beta-Globins; Brazil; Cross-Sectional Studies; Female; Fetal Hemog | 2012 |
L-arginine as an adjuvant drug in the treatment of sickle cell anaemia.
Topics: Adjuvants, Pharmaceutic; Anemia, Sickle Cell; Arginine; Erythrocyte Indices; Humans; Nitrites; Oxida | 2013 |
The role of iron overload on oxidative stress in sickle cell anemia.
Topics: Adult; Anemia, Sickle Cell; Female; Ferritins; Humans; Iron Overload; Male; Malondialdehyde; Nitrite | 2012 |
Mechanisms of vascular instability in a transgenic mouse model of sickle cell disease.
Topics: Anemia, Sickle Cell; Animals; Aorta; Autoantibodies; Blood Pressure; Calcimycin; Cyclic GMP; Disease | 2000 |
Low exhaled nitric oxide and a polymorphism in the NOS I gene is associated with acute chest syndrome.
Topics: Acute Disease; Adolescent; Anemia, Sickle Cell; Arginine; Breath Tests; Child; Citrulline; Forced Ex | 2001 |
Nitric oxide donor properties of hydroxyurea in patients with sickle cell disease.
Topics: Adolescent; Adult; Anemia, Sickle Cell; Female; Glutathione; Hemoglobins; Humans; Hydroxyurea; Lumin | 2002 |