nitrites has been researched along with Disease Models, Animal in 625 studies
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study evaluates the effects of agmatine on ovalbumin (OVA)-induced allergic inflammation of the airways." | 8.12 | Effect of Agmatine on a mouse model of allergic airway inflammation: A comparative study. ( Abdelaziz, RR; Elmahdi, HS; Suddek, GM; Еlmahdy, MK, 2022) |
| " This study aims at investigating AO effects on (i) latency to first seizure, seizure severity, weight loss, mortality rate, (ii) lipid peroxidation level, nitrite level, and catalase activity in the hippocampus after SE induced by pilocarpine (PC)." | 7.88 | Anticonvulsant effect of argan oil on pilocarpine model induced status epilepticus in wistar rats. ( Ammouri, H; Bahbiti, Y; Berkiks, I; Bikjdaouene, L; Chakit, M; Hessni, AE; Mesfioui, A; Nakache, R; Ouichou, A, 2018) |
| " Curcumin (diferuloylmethane), a major component of turmeric, exhibits protection against LPS-induced acute lung injury (ALI)." | 7.81 | Intranasal curcumin ameliorates lipopolysaccharide-induced acute lung injury in mice. ( Dash, D; Kumari, A; Singh, R; Tyagi, N, 2015) |
| "Compared with controls, sodium nitrite administered either pre-occlusion or pre-reperfusion markedly suppressed the number and severity of ventricular arrhythmias during occlusion and increased survival (0% vs." | 7.81 | Effect of sodium nitrite on ischaemia and reperfusion-induced arrhythmias in anaesthetized dogs: is protein S-nitrosylation involved? ( Gönczi, M; Kaszaki, J; Kiss, A; Kohr, MJ; Kovács, M; Miskolczi, G; Murphy, E; Seprényi, G; Végh, Á, 2015) |
| "Melatonin at 60 min post ischemia rendered neuroprotection as evident by reduction in cerebral infarct volume, improvement in motor and neurological deficit and reduction in brain edema." | 7.80 | Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia. ( Bhattacharya, P; Pandey, AK; Patnaik, R; Paul, S, 2014) |
| "Piperine produced significant antianxiety-like activity in unstressed and stressed mice." | 7.80 | Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice. ( Dhingra, D; Gilhotra, N, 2014) |
| "To investigate the effect of morphine on the reduced uteroplacental perfusion pressure (RUPP) model of pre-eclampsia in rats." | 7.79 | Effect of morphine on the reduced uteroplacental perfusion model of pre-eclampsia in rats. ( Dehpour, AR; Ejtemaei Mehr, S; Gharedaghi, MH; Javadi-Paydar, M; Javadian, P; Salmanian, B; Shamshirsaz, AA, 2013) |
| "To assess the protective effects of lycopene on electrocardiographic, hemodynamic, biochemical and apoptotic changes in isoproterenol induced myocardial infarction." | 7.78 | Tomato lycopene attenuates myocardial infarction induced by isoproterenol: electrocardiographic, biochemical and anti-apoptotic study. ( Aman, U; Balaraman, R; Vaibhav, P, 2012) |
| "To determine whether ebselen has a protective effect or antioxidative potential in a sodium-selenite-induced experimental cataract model." | 7.78 | Protective effects of ebselen on sodium-selenite-induced experimental cataract in rats. ( Aydemir, O; Deniz, N; Güler, M; Kaya, MK; Üstündağ, B, 2012) |
| "Mice were divided into: control group, colitis group (4% DSS for four days) and two pentamidine-treated colitis groups (0." | 7.78 | The antiprotozoal drug pentamidine ameliorates experimentally induced acute colitis in mice. ( Capoccia, E; Cirillo, C; Cuomo, R; Esposito, G; Sarnelli, G; Scuderi, C; Steardo, L, 2012) |
| "The purpose of this study was to develop a chronic chemically induced model of mild hyperhomocysteinemia in adult rats." | 7.77 | Development of an animal model for chronic mild hyperhomocysteinemia and its response to oxidative damage. ( da Cunha, AA; da Cunha, MJ; Delwing, D; Kolling, J; Lima, DD; Scherer, EB; Schmitz, F; Sitta, A; Vargas, CR; Wyse, AT, 2011) |
| "We designed the present study to evaluate the efficacy of melatonin (M) on the severity of necrotizing enterocolitis (NEC) in a neonatal rat model." | 7.77 | Melatonin ameliorates necrotizing enterocolitis in a neonatal rat model. ( Gundogdu, G; Guven, A; Korkmaz, A; Oztas, E; Ozturk, H; Uysal, B, 2011) |
| " Furthermore, we evaluated the effect of anti-dementia drugs memantine, a NMDA antagonist, and donepezil, a cholinesterase inhibitor, on OKA ICV induced memory impairment." | 7.76 | Okadaic acid (ICV) induced memory impairment in rats: a suitable experimental model to test anti-dementia activity. ( Kamat, PK; Nath, C; Saxena, G; Shukla, R; Tota, S, 2010) |
| " Previously, we reported that ICKT ameliorates murine concanavalin A (con A)-induced hepatitis via suppression of interferon (IFN)-gamma and interleukin (IL)-12 production." | 7.76 | Active ingredients of traditional Japanese (kampo) medicine, inchinkoto, in murine concanavalin A-induced hepatitis. ( Hasegawa, T; Kase, Y; Makino, B; Mase, A; Takeda, S; Tsuchiya, N; Yamamoto, M, 2010) |
| " Liver dysfunction in fructose-fed rats was evident from a rise in transaminase and total bilirubin, a decrease in the albumin/globulin ratio in plasma, a decrease in nitrite and arginase, and an increase in protein carbonyl and nitrosothiol content in the liver." | 7.76 | Insulin resistance induced by a high-fructose diet potentiates thioacetamide hepatotoxicity. ( Anuradha, CV; Pooranaperundevi, M; Sumiyabanu, MS; Sundarapandiyan, R; Viswanathan, P, 2010) |
| " Treatment with simvastatin attenuated goblet cell hyperplasia, arginase-1 protein expression, and total arginase enzyme activity, but it did not alter airway hydroxyproline content or transforming growth factor-β1." | 7.76 | Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling? ( Bratt, JM; Kenyon, NJ; Last, JA; Rabowsky, M; Zeki, AA, 2010) |
| "Population studies indicate that moderate hyperbilirubinemia is associated with reduced incidence of cardiovascular diseases, including hypertension." | 7.75 | Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice. ( Granger, JP; Stec, DE; Vera, T, 2009) |
| " The present study examined the effects of atorvastatin pretreatment on sepsis-induced endothelial dysfunctions and hypotension in rats." | 7.75 | Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis. ( Kathirvel, K; Kuntamallappanavar, G; Leo, MD; Mishra, SK; Subramani, J; Uttam Singh, T, 2009) |
| " The present study is aimed to investigate the effect of L-arginine (as a natural NO donor) supplementation on NO metabolite in a rabbit model of hypercholesterolemia to find a reliable marker for endothelial NO production." | 7.74 | L-arginine supplementation influenced nitrite but not nitrate and total nitrite in rabbit model of hypercholesterolemia. ( Haghjooy Javanmard, S; Monajemi, A; Nematbakhsh, M, 2008) |
| " We examined the role of neuropeptide Y (NPY) and neuronal nitric oxide synthase (nNOS) in modulating colitis." | 7.74 | Targeted deletion of neuropeptide Y (NPY) modulates experimental colitis. ( Bala, V; Chandrasekharan, B; Gewirtz, AT; Jones, D; Kolachala, VL; Sitaraman, SV; Srinivasan, S; Vijay-Kumar, M, 2008) |
| "These results suggest that pretreatment with atorvastatin attenuates APE-induced pulmonary hypertension and increases 24-hr survival rate by mechanisms that result in attenuated increases in lung activated MMP-9 after APE." | 7.74 | Protective effects of atorvastatin in rat models of acute pulmonary embolism: involvement of matrix metalloproteinase-9. ( Alves-Filho, JC; Cunha, FQ; Figueiredo-Lopes, L; Gerlach, RF; Semprini, MC; Souza-Costa, DC; Tanus-Santos, JE, 2007) |
| " The present study was designed to evaluate the effect of the methanol extract of Sorbus commixta cortex (MSC) on vascular inflammation in a rat model of the metabolic syndrome induced by a high Frc-diet." | 7.74 | Methanol extract of Sorbus commixta cortex prevents vascular inflammation in rats with a high fructose-induced metabolic syndrome. ( Kang, DG; Kim, JS; Lee, AS; Lee, DH; Lee, HS; Sohn, EJ, 2007) |
| "Sepsis is an arginine-deficient state and is associated with overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS)." | 7.74 | The effects of arginine and selective inducible nitric oxide synthase inhibitor on pathophysiology of sepsis in a CLP model. ( Akaishi, S; Endo, T; Hojo, N; Kobayashi, M; Kudo, D; Nomura, R; Sasaki, J; Shinozawa, Y; Takuma, K; Xie, XQ; Yamanouchi, S, 2008) |
| " This study was carried out to evaluate if inhibited angiogenesis by Suramin injections in early pregnancy may cause a condition resembling pre-eclampsia in rats." | 7.73 | Placental dysfunction in Suramin-treated rats--a new model for pre-eclampsia. ( Eriksson, UJ; Jansson, L; Lindeberg, S; Naessén, T; Nash, P; Olovsson, M; Wentzel, P, 2005) |
| "To investigate the systemic, pulmonary, and hepatosplanchnic hemodynamic and metabolic effects of delayed treatment with ethyl pyruvate in a long-term porcine model of hyperdynamic endotoxemia." | 7.73 | Ethyl pyruvate improves systemic and hepatosplanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia. ( Albicini, M; Asfar, P; Bracht, H; Brückner, UB; Ehrmann, U; Fink, MP; Hauser, B; Kick, J; Radermacher, P; Vogt, J; Wachter, U, 2005) |
| "To investigate if resveratrol can prevent sodium selenite-induced experimental cataract model in rats." | 7.73 | The effect of resveratrol in experimental cataract model formed by sodium selenite. ( Borazan, M; Cigremis, Y; Doganay, S; Iraz, M, 2006) |
| "To assess the antioxidant effects of atorvastatin (atorva) on dexamethasone (dex)-induced hypertension, 60 male Sprague-Dawley rats were treated with atorva 30 mg/kg/day or tap water for 15 days." | 7.73 | Atorvastatin prevented and reversed dexamethasone-induced hypertension in the rat. ( Huang, TG; Mondo, CK; Su, JZ; Yang, WS, 2006) |
| "To clarify the role of nitric oxide (NO) in the pathogenesis of seizures in susceptible EL mice, we investigated effects of three drugs potentially related to NO production, MK-801, dantrolene, and FK506, on convulsive seizures and brain NO metabolites (NOx)." | 7.71 | Effects of MK-801, dantrolene, and FK506 on convulsive seizures and brain nitric oxide production in seizure-susceptible EL mice. ( Akasaki, Y; Hashiguchi, W; Nagatomo, I; Takigawa, M; Tominaga, M; Uchida, M, 2001) |
| "Hyperhomocysteinemia (HH) is an independent risk factor for atherosclerosis, including peripheral arterial occlusive disease (PAOD)." | 7.70 | Hyperhomocysteinemia impairs angiogenesis in response to hindlimb ischemia. ( Akita, T; Duan, J; Ikeda, H; Imaizumi, T; Murohara, T; Sasaki, K; Shimada, T; Shintani, S, 2000) |
| "To investigate the role of carbon monoxide (CO) in the pathogenesis of asthma." | 7.70 | [Evidence of increased endogenous carbon monoxide production in asthma]. ( Jiang, D; Li, H; Shi, Y, 1999) |
| "To elucidate the role of bradykinin in the complex pathophysiology of bacterial meningitis we investigated the effect of the bradykinin B2 receptor antagonist Hoe140, icatibant (D-Arg[Hyp3-Thi5-D-Tic7-Oic8]-bradykinin), on pathophysiological alterations in experimental pneumococcal meningitis." | 7.69 | Effect of the bradykinin B2 receptor antagonist Hoe140 in experimental pneumococcal meningitis in the rat. ( Frei, K; Ködel, U; Lorenzl, S; Pfister, HW, 1996) |
| "To investigate changes in regional blood flows (RBF) and vascular porosity during the early phase of the autologous collagen II induced arthritis model (CIA) in rats and the possible influence of indomethacin and nitric oxide (NO) synthase on these variables." | 7.69 | Changes in vascular porosity and joint blood flow during development of collagen induced arthritis in the rat. Modulation by indomethacin and L-NAME. ( Andersson, SE; Ekström, GM, 1997) |
| "Seizures were induced by pentylenetetrazol and maximal electroshock." | 5.72 | Opioidergic and nitrergic systems mediate the anticonvulsant effect of mefloquine and chloroquine on seizures induced by pentylenetetrazol and maximal electroshock in mice. ( Boroujeni, SS; Dehpour, AR; Jafari, RM; Karimi, E; Maleki, A; Mohammadi, P; Sabzevari, O; Shafaroodi, H; Solaimanian, S, 2022) |
| "Bronchial asthma is a chronic lung disorder, that affects an estimated 262 million people worldwide, thereby, causing a large socio-economic burden." | 5.72 | Orally administered solasodine, a steroidal glycoalkaloid, suppresses ovalbumin-induced exaggerated Th2-immune response in rat model of bronchial asthma. ( Arora, P; Chellappan, DK; Dua, K; Gupta, G; Nainwal, LM; Oliver, BG; Singh, SK, 2022) |
| "Levosimendan was administered after ROSC with a loading dose of 10 μg/kg and then infused at 0." | 5.56 | Synergistic Effects of Moderate Therapeutic Hypothermia and Levosimendan on Cardiac Function and Survival After Asphyxia-Induced Cardiac Arrest in Rats. ( Chang, WT; Chen, WJ; Huang, CH; Tsai, MS; Wang, CH, 2020) |
| "Ischemia was followed by a significant increase in muscle myeloperoxidase activity, as well as interleukin-6 and thiobarbituric acid reactive substances species levels." | 5.48 | N-acetylcysteine effects on a murine model of chronic critical limb ischemia. ( Constantino, L; da Silva, LA; Dal-Pizzol, F; Dall'Igna, DM; de Medeiros, WA; Dos Santos Cardoso, J; Manfredini, A; Michels, M; Ritter, C; Scaini, G; Streck, EL; Vuolo, F, 2018) |
| "Mild hyperhomocysteinemia is considered a risk factor for development of neurodegenerative diseases." | 5.48 | Chronic Mild Hyperhomocysteinemia Alters Inflammatory and Oxidative/Nitrative Status and Causes Protein/DNA Damage, as well as Ultrastructural Changes in Cerebral Cortex: Is Acetylsalicylic Acid Neuroprotective? ( de S Moreira, D; Figueiró, PW; Guma, FCR; Manfredini, V; Prezzi, CA; Rohden, F; Siebert, C; Wyse, ATS, 2018) |
| "Dimethyl fumarate (DMF) is an important agent against inflammatory response and reactive species in CNS disorders." | 5.48 | Dimethyl Fumarate Limits Neuroinflammation and Oxidative Stress and Improves Cognitive Impairment After Polymicrobial Sepsis. ( Barichello, T; da Rosa, N; Danielski, LG; de Oliveira Junior, AN; de Souza Goldim, MP; Florentino, D; Fortunato, JJ; Giustina, AD; Gomes, ML; Laurentino, AO; Mathias, K; Moreira, AP; Petronilho, F; Schuck, PF; Steckert, AV; Trombetta, T; Zarbato, GF, 2018) |
| " Further studies evaluating longer-duration nitrite therapy and/or additional nitrite dosing strategies are warranted to more fully evaluate the therapeutic potential of nitrite therapy in peripheral vascular disease." | 5.42 | Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome. ( Bradley, JM; Brewster, LP; Calvert, JW; Chang, CC; Goodchild, TT; Islam, KN; Lefer, DJ; Pipinos, II; Polhemus, DJ; Tao, YX, 2015) |
| "5 improved most of the parameters evaluated in this study without causing motor impairment demonstrating, thus, that possibly when combined with ALA a lower dose of CLZ is required." | 5.42 | Alpha-lipoic acid alone and combined with clozapine reverses schizophrenia-like symptoms induced by ketamine in mice: Participation of antioxidant, nitrergic and neurotrophic mechanisms. ( de Lucena, DF; de Sousa, CN; Gama, CS; Lima, LL; Macêdo, D; Oliveira, Tde Q; Vasconcelos, GS; Vasconcelos, SM; Ximenes, NC, 2015) |
| "Hypertension is a common disease that includes oxidative stress as a major feature, and oxidative stress impairs physiological nitric oxide (NO) activity promoting cardiovascular pathophysiological mechanisms." | 5.42 | Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension. ( Amaral, JH; Ferreira, GC; Montenegro, MF; Pinheiro, LC; Tanus-Santos, JE, 2015) |
| "Honokiol (HNK) is a biphenolic neolignan possessing multiple biological activities including antioxidant, anti-inflammatory, anxiolytic, antidepressant and neuroprotective." | 5.40 | Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice. ( Baruah, CC; Dwivedi, S; Hazarika, NK; Jangra, A; Kumar, P; Lahkar, M; Sulakhiya, K, 2014) |
| "Acute lung injury is still a significant clinical problem with a high mortality rate and there are few effective therapies in clinic." | 5.38 | Ruscogenin inhibits lipopolysaccharide-induced acute lung injury in mice: involvement of tissue factor, inducible NO synthase and nuclear factor (NF)-κB. ( Chen, L; Gao, M; Jiang, W; Kou, J; Li, J; Shao, F; Sun, Q; Wang, J; Yu, B, 2012) |
| "Cepharanthine (CE) is a plant alkaloid that possesses bioactive properties, with various known actions." | 5.37 | Cepharanthine exerts anti-inflammatory effects via NF-κB inhibition in a LPS-induced rat model of systemic inflammation. ( Hagiwara, S; Hasegawa, A; Koga, H; Kudo, K; Kusaka, J; Noguchi, T, 2011) |
| "Post-treatment with magnolol significantly attenuated the deleterious haemodynamic changes (e." | 5.36 | Beneficial effects of magnolol in a rodent model of endotoxin shock. ( Cheng, PY; Ke, TH; Kung, CW; Peng, YJ; Tsai, YC; Wang, JJ; Yen, MH, 2010) |
| "Indomethacin treatment significantly decreased cotton pellet implantation induced white blood cell count elevation and immune cells infiltration in epididymal white adipose tissue." | 5.36 | Indomethacin activates peroxisome proliferator-activated receptor γ to improve insulin resistance in cotton pellet granuloma model. ( Chen, W; Cheng, JT; Cheng, KC; Shen, KH; Wu, HT; Yeh, CH, 2010) |
| "Allergen-induced lung inflammation was potentiated in mice with elevated circulating ADMA and was reduced in mice overexpressing DDAH." | 5.36 | Asymmetric dimethylarginine potentiates lung inflammation in a mouse model of allergic asthma. ( Buford, MC; Holian, A; Klein, E; Weigel, J; Wells, SM, 2010) |
| "Hypercholesterolemia is a major risk factor for the development and progression of cardiovascular diseases including atherosclerosis." | 5.35 | Suppression of diet-induced hypercholesterolemia by scutellarin in rats. ( Chan, SW; Chen, SL; Cheng, HL; Guo, DJ; Li, Q; Wu, JH, 2009) |
| "Treatment with hesperidin showed a significant increase in tissue nitrite, antioxidant level and reduction in inflammation, arrhythmias and apoptosis." | 5.35 | Protection against in vivo focal myocardial ischemia/reperfusion injury-induced arrhythmias and apoptosis by hesperidin. ( Balaraman, R; Gandhi, C; Upaganalawar, A, 2009) |
| "Ozone treatment significantly reduced the severity of NEC by modulating antioxidative defense and antiinflammatory protection in our experimental animal model." | 5.35 | Medical ozone therapy reduces oxidative stress and intestinal damage in an experimental model of necrotizing enterocolitis in neonatal rats. ( Gundogdu, G; Guven, A; Korkmaz, A; Oztas, E; Ozturk, H; Uysal, B; Vurucu, S, 2009) |
| "Proteinuria was significantly lower in L-arginine-treated animals from week 24 onward (p<0." | 5.32 | Long-term dietary L-arginine supplementation attenuates proteinuria and focal glomerulosclerosis in experimental chronic renal transplant failure. ( Albrecht, EW; Smit-van Oosten, A; Stegeman, CA; van Goor, H, 2003) |
| " L-NAME treatment, applied at the dosage of 50 mg/kg/day, does not have any protective effect on the colonic injury." | 5.32 | Effects of intrarectal and intraperitoneal N(G)-nitro-L-arginine methyl ester treatment in 2,4,6-trinitrobenzenesulfonic acid induced colitis in rats. ( Angin, K; Dundar, E; Inal, M; Saricam, T; Vardareli, E, 2003) |
| "enalapril alone to enhance vascular effects, increase LV contractility and prevent unfavorable remodeling and are consistent with vascular delivery of exogenous NO." | 5.32 | A nitric oxide-releasing derivative of enalapril, NCX 899, prevents progressive cardiac dysfunction and remodeling in hamsters with heart failure. ( Condorelli, G; Del Soldato, P; Dieterle, T; Gu, Y; Iwanaga, Y; Ongini, E; Peterson, KL; Presotto, C; Ross, J, 2004) |
| " This study evaluates the effects of agmatine on ovalbumin (OVA)-induced allergic inflammation of the airways." | 4.12 | Effect of Agmatine on a mouse model of allergic airway inflammation: A comparative study. ( Abdelaziz, RR; Elmahdi, HS; Suddek, GM; Еlmahdy, MK, 2022) |
| " Our aim was to examine local and remote consequences of ASA-Tris administration in 2-,4-,6-trinitrobenzene-sulfonic acid (TNBS)-induced colitis as compared to ASA or mesalamine (5-aminosalicylate) treatment." | 3.88 | Acetylsalicylic acid-tris-hydroxymethyl-aminomethane reduces colon mucosal damage without causing gastric side effects in a rat model of colitis. ( Boros, M; Érces, D; Ghyczy, M; Hartmann, P; Jász, DK; Lajkó, N; Molnár, R; Szűcs, S; Tóth, G; Ugocsai, M; Varga, G, 2018) |
| "Abrupt discontinuation of chronic amphetamine consumption leads to withdrawal symptoms including depression, anhedonia, dysphoria, fatigue, and anxiety." | 3.88 | Involvement of NO/NMDA-R pathway in the behavioral despair induced by amphetamine withdrawal. ( Afshari, K; Amini-Khoei, H; Amiri, S; Dehpour, AR; Ghesmati, M; Haj-Mirzaian, A; Hashemiaghdam, A; Ramezanzadeh, K, 2018) |
| " This study aims at investigating AO effects on (i) latency to first seizure, seizure severity, weight loss, mortality rate, (ii) lipid peroxidation level, nitrite level, and catalase activity in the hippocampus after SE induced by pilocarpine (PC)." | 3.88 | Anticonvulsant effect of argan oil on pilocarpine model induced status epilepticus in wistar rats. ( Ammouri, H; Bahbiti, Y; Berkiks, I; Bikjdaouene, L; Chakit, M; Hessni, AE; Mesfioui, A; Nakache, R; Ouichou, A, 2018) |
| "7 macrophages) and in vivo, in the trinitrobenzenesulfonic acid (TNBS) model of rat colitis." | 3.83 | Antiinflammatory and immunomodulatory activity of an ethanolic extract from the stem bark of Terminalia catappa L. (Combretaceae): In vitro and in vivo evidences. ( Abiodun, OO; Algieri, F; Galvez, J; Gomez-Caravaca, AM; Rodriguez-Cabezas, ME; Rodríguez-Nogales, A; Segura-Carretero, A; Utrilla, MP, 2016) |
| "Here we show that wild-type mice infused with angiotensin II develop hypertension, cardiac hypertrophy, perivascular fibrosis, and endothelial dysfunction with enhanced stromal interaction molecule 1 (STIM1) expression in heart and vessels." | 3.83 | Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular Dysfunction. ( Ait-Aissa, K; Belmadani, S; Gabani, M; Haddox, S; Irani, K; Kassan, M; Mali, V; Matrougui, K; Radwan, E; Trebak, M; Zhang, W, 2016) |
| " Curcumin (diferuloylmethane), a major component of turmeric, exhibits protection against LPS-induced acute lung injury (ALI)." | 3.81 | Intranasal curcumin ameliorates lipopolysaccharide-induced acute lung injury in mice. ( Dash, D; Kumari, A; Singh, R; Tyagi, N, 2015) |
| "Compared with controls, sodium nitrite administered either pre-occlusion or pre-reperfusion markedly suppressed the number and severity of ventricular arrhythmias during occlusion and increased survival (0% vs." | 3.81 | Effect of sodium nitrite on ischaemia and reperfusion-induced arrhythmias in anaesthetized dogs: is protein S-nitrosylation involved? ( Gönczi, M; Kaszaki, J; Kiss, A; Kohr, MJ; Kovács, M; Miskolczi, G; Murphy, E; Seprényi, G; Végh, Á, 2015) |
| "Melatonin at 60 min post ischemia rendered neuroprotection as evident by reduction in cerebral infarct volume, improvement in motor and neurological deficit and reduction in brain edema." | 3.80 | Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia. ( Bhattacharya, P; Pandey, AK; Patnaik, R; Paul, S, 2014) |
| " The electrophilic lipid 10-nitro-oleic acid (NO2-OA) inhibited hydrolase activity and also lowered BP in an angiotensin II-induced hypertension model in wild-type (WT) but not KI mice." | 3.80 | Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. ( Charles, RL; Eaton, P; Freeman, BA; Hammock, BD; Kamynina, A; Morisseau, C; Prysyazhna, O; Rudyk, O; Yang, J, 2014) |
| "Piperine produced significant antianxiety-like activity in unstressed and stressed mice." | 3.80 | Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice. ( Dhingra, D; Gilhotra, N, 2014) |
| "More studies are still warranted in similar rodent models of pain and depression, so, that the present findings can be further substantiated to establish the clinical effectiveness of berberine in a subset of patients suffering from pain as well as depression." | 3.79 | Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model. ( Arora, V; Chopra, K, 2013) |
| " In vivo anti-inflammatory effect was examined in ethylphenylpropiolate (EPP)-induced ear edema and carrageenan-induced paw edema in rat models." | 3.79 | Molecular mechanism of anti-inflammatory activity of Pluchea indica leaves in macrophages RAW 264.7 and its action in animal models ofinflammation. ( Buapool, D; Chantimal, J; Mongkol, N; Roytrakul, S; Srisook, E; Srisook, K, 2013) |
| "To investigate the effect of morphine on the reduced uteroplacental perfusion pressure (RUPP) model of pre-eclampsia in rats." | 3.79 | Effect of morphine on the reduced uteroplacental perfusion model of pre-eclampsia in rats. ( Dehpour, AR; Ejtemaei Mehr, S; Gharedaghi, MH; Javadi-Paydar, M; Javadian, P; Salmanian, B; Shamshirsaz, AA, 2013) |
| "To assess the protective effects of lycopene on electrocardiographic, hemodynamic, biochemical and apoptotic changes in isoproterenol induced myocardial infarction." | 3.78 | Tomato lycopene attenuates myocardial infarction induced by isoproterenol: electrocardiographic, biochemical and anti-apoptotic study. ( Aman, U; Balaraman, R; Vaibhav, P, 2012) |
| " The analgesic activity was examined against oxytocin-induced dysmenorrhea in mice." | 3.78 | Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii. ( Chen, T; Duan, JA; Gu, W; Hua, Y; Jiang, H; Su, S; Tang, Y; Wang, Y; Zhou, W, 2012) |
| "The present study was aimed to evaluate the antihypertensive effect of diosmin in deoxycorticosterone acetate (DOCA)-salt induced hypertension in male Wistar rats." | 3.78 | Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats. ( Raja, B; Silambarasan, T, 2012) |
| " Ozone therapy (OT) is shown to reduce inflammation and necrosis in several entities." | 3.78 | The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury. ( Akgul, EO; Cakir, E; Cayci, T; Demirbag, S; Eyi, YE; Gul, H; Kaldirim, U; Korkmaz, A; Macit, E; Oter, S; Ozler, M; Oztas, E; Topal, T; Toygar, M; Uysal, B; Yaman, H; Yildirim, AO, 2012) |
| " In order to examine the involvement of nitric oxide (NO) on stress-induced neurobehavioral changes and the concomitant alterations of neuroendocrinological factors, we studied the effects of the nonselective NOS inhibitor, N(ω)-Nitro L-arginine methyl ester hydrochloride (L-NAME) and the specific neuronal NOS inhibitor, 7-nitroindazole (7-NI) on restraint stress-induced anxiety in the elevated plus maze (EPM) test and biochemical analysis." | 3.78 | The differential role of NOS inhibitors on stress-induced anxiety and neuroendocrine alterations in the rat. ( Her, S; Joung, HY; Jung, EY; Kim, K; Lee, MS; Shim, I, 2012) |
| "To determine whether ebselen has a protective effect or antioxidative potential in a sodium-selenite-induced experimental cataract model." | 3.78 | Protective effects of ebselen on sodium-selenite-induced experimental cataract in rats. ( Aydemir, O; Deniz, N; Güler, M; Kaya, MK; Üstündağ, B, 2012) |
| "Mice were divided into: control group, colitis group (4% DSS for four days) and two pentamidine-treated colitis groups (0." | 3.78 | The antiprotozoal drug pentamidine ameliorates experimentally induced acute colitis in mice. ( Capoccia, E; Cirillo, C; Cuomo, R; Esposito, G; Sarnelli, G; Scuderi, C; Steardo, L, 2012) |
| "Hyperhomocysteinemia is a risk factor for cardiovascular disease, stroke, and thrombosis; however, the mechanisms by which homocysteine triggers these dysfunctions are not fully understood." | 3.77 | Homocysteine induces oxidative-nitrative stress in heart of rats: prevention by folic acid. ( da Cunha, AA; da Cunha, MJ; Kolling, J; Scherer, EB; Wyse, AT, 2011) |
| "The purpose of this study was to develop a chronic chemically induced model of mild hyperhomocysteinemia in adult rats." | 3.77 | Development of an animal model for chronic mild hyperhomocysteinemia and its response to oxidative damage. ( da Cunha, AA; da Cunha, MJ; Delwing, D; Kolling, J; Lima, DD; Scherer, EB; Schmitz, F; Sitta, A; Vargas, CR; Wyse, AT, 2011) |
| "We designed the present study to evaluate the efficacy of melatonin (M) on the severity of necrotizing enterocolitis (NEC) in a neonatal rat model." | 3.77 | Melatonin ameliorates necrotizing enterocolitis in a neonatal rat model. ( Gundogdu, G; Guven, A; Korkmaz, A; Oztas, E; Ozturk, H; Uysal, B, 2011) |
| " Furthermore, we evaluated the effect of anti-dementia drugs memantine, a NMDA antagonist, and donepezil, a cholinesterase inhibitor, on OKA ICV induced memory impairment." | 3.76 | Okadaic acid (ICV) induced memory impairment in rats: a suitable experimental model to test anti-dementia activity. ( Kamat, PK; Nath, C; Saxena, G; Shukla, R; Tota, S, 2010) |
| " Previously, we reported that ICKT ameliorates murine concanavalin A (con A)-induced hepatitis via suppression of interferon (IFN)-gamma and interleukin (IL)-12 production." | 3.76 | Active ingredients of traditional Japanese (kampo) medicine, inchinkoto, in murine concanavalin A-induced hepatitis. ( Hasegawa, T; Kase, Y; Makino, B; Mase, A; Takeda, S; Tsuchiya, N; Yamamoto, M, 2010) |
| "Specific dietary polyphenols, in particular quercetin and theaflavin, may attenuate atherosclerosis in ApoE(-/-) gene-knockout mice by alleviating inflammation, improving NO bioavailability, and inducing heme oxygenase-1." | 3.76 | Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction. ( Croft, KD; Hime, N; Hodgson, JM; Loke, WM; Magat, M; McKinley, AJ; Proudfoot, JM; Stocker, R, 2010) |
| " To clarify the role of NO in inflammation, we studied carrageenin-induced pleurisy in rats treated with an NO donor (NOC-18), a substrate for NO formation (L-arginine), and/or an NO synthase inhibitor (S-(2-aminoethyl) isothiourea or N(G)-nitro-L-arginine)." | 3.76 | Involvement of nitric oxide in a rat model of carrageenin-induced pleurisy. ( Asai, Y; Inoue, T; Iwata, M; Suzuki, S; Takagi, K, 2010) |
| " Liver dysfunction in fructose-fed rats was evident from a rise in transaminase and total bilirubin, a decrease in the albumin/globulin ratio in plasma, a decrease in nitrite and arginase, and an increase in protein carbonyl and nitrosothiol content in the liver." | 3.76 | Insulin resistance induced by a high-fructose diet potentiates thioacetamide hepatotoxicity. ( Anuradha, CV; Pooranaperundevi, M; Sumiyabanu, MS; Sundarapandiyan, R; Viswanathan, P, 2010) |
| " Treatment with simvastatin attenuated goblet cell hyperplasia, arginase-1 protein expression, and total arginase enzyme activity, but it did not alter airway hydroxyproline content or transforming growth factor-β1." | 3.76 | Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling? ( Bratt, JM; Kenyon, NJ; Last, JA; Rabowsky, M; Zeki, AA, 2010) |
| "This study was carried out in order to investigate the effects of epigallocatechin gallate (EGCG) on myocardial fibrosis and cell proliferation in cardiac hypertrophy." | 3.75 | EGCG inhibits proliferation of cardiac fibroblasts in rats with cardiac hypertrophy. ( Gu, ZL; Guo, CY; Sheng, R; Xie, ML; Zhou, WX, 2009) |
| "Population studies indicate that moderate hyperbilirubinemia is associated with reduced incidence of cardiovascular diseases, including hypertension." | 3.75 | Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice. ( Granger, JP; Stec, DE; Vera, T, 2009) |
| " The present study examined the effects of atorvastatin pretreatment on sepsis-induced endothelial dysfunctions and hypotension in rats." | 3.75 | Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis. ( Kathirvel, K; Kuntamallappanavar, G; Leo, MD; Mishra, SK; Subramani, J; Uttam Singh, T, 2009) |
| "The impact of L-arginine on atherogenesis and its ability to prevent endothelial dysfunction have been studied extensively during the past years." | 3.74 | The prevention of endothelial dysfunction through endothelial cell apoptosis inhibition in a hypercholesterolemic rabbit model: the effect of L-arginine supplementation. ( Haghjooyjavanmard, S; Mahmoodi, F; Monajemi, AR; Nematbakhsh, M, 2008) |
| " The present study is aimed to investigate the effect of L-arginine (as a natural NO donor) supplementation on NO metabolite in a rabbit model of hypercholesterolemia to find a reliable marker for endothelial NO production." | 3.74 | L-arginine supplementation influenced nitrite but not nitrate and total nitrite in rabbit model of hypercholesterolemia. ( Haghjooy Javanmard, S; Monajemi, A; Nematbakhsh, M, 2008) |
| " We examined the role of neuropeptide Y (NPY) and neuronal nitric oxide synthase (nNOS) in modulating colitis." | 3.74 | Targeted deletion of neuropeptide Y (NPY) modulates experimental colitis. ( Bala, V; Chandrasekharan, B; Gewirtz, AT; Jones, D; Kolachala, VL; Sitaraman, SV; Srinivasan, S; Vijay-Kumar, M, 2008) |
| "These results suggest that pretreatment with atorvastatin attenuates APE-induced pulmonary hypertension and increases 24-hr survival rate by mechanisms that result in attenuated increases in lung activated MMP-9 after APE." | 3.74 | Protective effects of atorvastatin in rat models of acute pulmonary embolism: involvement of matrix metalloproteinase-9. ( Alves-Filho, JC; Cunha, FQ; Figueiredo-Lopes, L; Gerlach, RF; Semprini, MC; Souza-Costa, DC; Tanus-Santos, JE, 2007) |
| " The present study was designed to evaluate the effect of the methanol extract of Sorbus commixta cortex (MSC) on vascular inflammation in a rat model of the metabolic syndrome induced by a high Frc-diet." | 3.74 | Methanol extract of Sorbus commixta cortex prevents vascular inflammation in rats with a high fructose-induced metabolic syndrome. ( Kang, DG; Kim, JS; Lee, AS; Lee, DH; Lee, HS; Sohn, EJ, 2007) |
| "Previous studies indicate that adenosine supplementation or nitric oxide synthase (NOS) inhibition during reperfusion exert protective effects against myocardial ischemia-reperfusion (I/R) injury." | 3.74 | Delayed 24 hours Nomega-nitro-L-arginine methyl ester injection induces pharmacological cardioprotection against reperfusion injury. ( Bouhaddi, M; Davani, S; Kantelip, JP; Reyssie, H; Rochette, L; Royer, B; Vergely, C, 2007) |
| " The aim of this study was to assess the effects of simvastatin on rats with TAA-induced acute liver damage and hepatic encephalopathy." | 3.74 | Simvastatin for rats with thioacetamide-induced liver failure and encephalopathy. ( Chan, CY; Chang, FY; Chen, YC; Chu, CJ; Huang, HC; Lee, FY; Lee, SD; Lin, HC; Wang, SS, 2008) |
| " With this background, the present study was designed to explore the possible effect of nimesulide (a preferential COX-2 inhibitor) against pentylenetetrazol (PTZ)-induced kindling epilepsy in mice." | 3.74 | Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor, against pentylenetetrazol (PTZ)-induced chemical kindling and associated biochemical parameters in mice. ( Dhir, A; Kulkarni, SK; Naidu, PS, 2007) |
| "Sepsis is an arginine-deficient state and is associated with overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS)." | 3.74 | The effects of arginine and selective inducible nitric oxide synthase inhibitor on pathophysiology of sepsis in a CLP model. ( Akaishi, S; Endo, T; Hojo, N; Kobayashi, M; Kudo, D; Nomura, R; Sasaki, J; Shinozawa, Y; Takuma, K; Xie, XQ; Yamanouchi, S, 2008) |
| "Subacute sodium nitrite infusions prevented delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage." | 3.73 | Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage. ( Dejam, A; Gladwin, MT; Grimes, G; Oldfield, EH; Pluta, RM, 2005) |
| " The evolution of systolic blood pressure was followed by weekly measurements, and morphological variables, proteinuria, plasma nitrates plus nitrites (NOx) and thiobarbituric acid reactive substances (TBARS), liver oxidative stress markers and endothelial function were determined at the end of the experimental period." | 3.73 | Effects of chronic quercetin treatment in experimental renovascular hypertension. ( Bermejo, A; Duarte, J; Galisteo, M; García-Saura, MF; Vargas, F; Villar, IC; Zarzuelo, A, 2005) |
| " This study was carried out to evaluate if inhibited angiogenesis by Suramin injections in early pregnancy may cause a condition resembling pre-eclampsia in rats." | 3.73 | Placental dysfunction in Suramin-treated rats--a new model for pre-eclampsia. ( Eriksson, UJ; Jansson, L; Lindeberg, S; Naessén, T; Nash, P; Olovsson, M; Wentzel, P, 2005) |
| "To investigate the systemic, pulmonary, and hepatosplanchnic hemodynamic and metabolic effects of delayed treatment with ethyl pyruvate in a long-term porcine model of hyperdynamic endotoxemia." | 3.73 | Ethyl pyruvate improves systemic and hepatosplanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia. ( Albicini, M; Asfar, P; Bracht, H; Brückner, UB; Ehrmann, U; Fink, MP; Hauser, B; Kick, J; Radermacher, P; Vogt, J; Wachter, U, 2005) |
| "To investigate if resveratrol can prevent sodium selenite-induced experimental cataract model in rats." | 3.73 | The effect of resveratrol in experimental cataract model formed by sodium selenite. ( Borazan, M; Cigremis, Y; Doganay, S; Iraz, M, 2006) |
| "To assess the antioxidant effects of atorvastatin (atorva) on dexamethasone (dex)-induced hypertension, 60 male Sprague-Dawley rats were treated with atorva 30 mg/kg/day or tap water for 15 days." | 3.73 | Atorvastatin prevented and reversed dexamethasone-induced hypertension in the rat. ( Huang, TG; Mondo, CK; Su, JZ; Yang, WS, 2006) |
| "Peritonitis sepsis induced multiple organ dysfunction, mitochondrial abnormalities, and increased mortality rate, which were reduced by pharmacological inhibition of mitochondrial transition by cyclosporine derivatives and mitochondrial Bcl-2 overexpression." | 3.73 | Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality. ( Chopin, C; Decoster, B; Favory, R; Hassoun, SM; Lancel, S; Larche, J; Marchetti, P; Neviere, R, 2006) |
| " Progression of the chronic synovitis in zymosan-induced arthritis (ZYA) was associated with increased nitrite and nitrotyrosine (3-NT) levels in the joint exudates that paralleled a progressive loss of the GAG content." | 3.72 | Reactive nitrogen species scavenging, rather than nitric oxide inhibition, protects from articular cartilage damage in rat zymosan-induced arthritis. ( Bezerra, MM; Brain, SD; da Rocha, FA; de Melo, LB; Greenacre, S; Jerônimo, SM; Keeble, J, 2004) |
| " Body weight, urinary pyridinoline (Pyr), deoxypyridinoline (DPyr) corrected for urinary creatinine, serum nitrite/nitrate concentrations and whole body and femoral bone mineral density (BMD) were measured." | 3.72 | The effects of hyaluronan on bone resorption and bone mineral density in a rat model of estrogen deficiency-induced osteopenia. ( Istok, R; Rovenský, J; Stancíková, M; Svík, K; Velebný, V, 2004) |
| "The expression of HO-1 and iNOS in aorta increased with the SBP elevation during the development of SHR and was attenuated when the hypertension was lowered with the vasodilator hydralazine." | 3.72 | The expression of heme oxygenase-1 and inducible nitric oxide synthase in aorta during the development of hypertension in spontaneously hypertensive rats. ( Chen, JJ; Cheng, PY; Yen, MH, 2004) |
| "To clarify the role of nitric oxide (NO) in the pathogenesis of seizures in susceptible EL mice, we investigated effects of three drugs potentially related to NO production, MK-801, dantrolene, and FK506, on convulsive seizures and brain NO metabolites (NOx)." | 3.71 | Effects of MK-801, dantrolene, and FK506 on convulsive seizures and brain nitric oxide production in seizure-susceptible EL mice. ( Akasaki, Y; Hashiguchi, W; Nagatomo, I; Takigawa, M; Tominaga, M; Uchida, M, 2001) |
| "We conclude that hypoxia-induced HTN is associated with depressed NO production and can be mitigated by L-arginine supplementation." | 3.70 | Role of endothelin and nitric oxide imbalance in the pathogenesis of hypoxia-induced arterial hypertension. ( Bemanian, S; Kivlighn, SD; Ni, Z; Vaziri, ND, 1998) |
| " Thus, the objective of this study was to assess the role of iNOS in modulating neutrophil (PMN) extravasation in an oyster glycogen-induced model of acute peritonitis in rats." | 3.70 | Role of inducible nitric oxide synthase in leukocyte extravasation in vivo. ( Cockrell, A; Gray, L; Grisham, MB; Jourd'heuil, D; Kawachi, S; Laroux, FS; Van der Heyde, H, 1999) |
| "In the process of developing a model of Escherichia coli endotoxin-induced acute lung injury and shock in specific pathogen-free pigs, the effects of pretreatment with metyrapone (a cortisol-synthesis inhibitor) were examined." | 3.70 | Effect of cortisol-synthesis inhibition on endotoxin-induced porcine acute lung injury, shock, and nitric oxide production. ( Alving, K; Bergman, D; Middelveld, RJ; Wanecek, M; Weitzberg, E, 1999) |
| "Hyperhomocysteinemia (HH) is an independent risk factor for atherosclerosis, including peripheral arterial occlusive disease (PAOD)." | 3.70 | Hyperhomocysteinemia impairs angiogenesis in response to hindlimb ischemia. ( Akita, T; Duan, J; Ikeda, H; Imaizumi, T; Murohara, T; Sasaki, K; Shimada, T; Shintani, S, 2000) |
| "To investigate the role of carbon monoxide (CO) in the pathogenesis of asthma." | 3.70 | [Evidence of increased endogenous carbon monoxide production in asthma]. ( Jiang, D; Li, H; Shi, Y, 1999) |
| " In order to evaluate the participation of nitric oxide and superoxide in such diseases, we examined the expression of nitric oxide synthase (NOS) and superoxide dismutase (SOD) as well as their activities in whole excised colons of rats with colitis induced by intralumenal administration of 2,4,6-trinitrobenzenesulfonic acid." | 3.69 | Induction of nitric oxide synthase and concomitant suppression of superoxide dismutases in experimental colitis in rats. ( Fujii, J; Nakamura, M; Seo, HG; Suzuki, K; Takata, I; Taniguchi, N; Tatsumi, H, 1995) |
| "To elucidate the role of bradykinin in the complex pathophysiology of bacterial meningitis we investigated the effect of the bradykinin B2 receptor antagonist Hoe140, icatibant (D-Arg[Hyp3-Thi5-D-Tic7-Oic8]-bradykinin), on pathophysiological alterations in experimental pneumococcal meningitis." | 3.69 | Effect of the bradykinin B2 receptor antagonist Hoe140 in experimental pneumococcal meningitis in the rat. ( Frei, K; Ködel, U; Lorenzl, S; Pfister, HW, 1996) |
| "To investigate changes in regional blood flows (RBF) and vascular porosity during the early phase of the autologous collagen II induced arthritis model (CIA) in rats and the possible influence of indomethacin and nitric oxide (NO) synthase on these variables." | 3.69 | Changes in vascular porosity and joint blood flow during development of collagen induced arthritis in the rat. Modulation by indomethacin and L-NAME. ( Andersson, SE; Ekström, GM, 1997) |
| " Chronic ileitis was induced in guinea pigs by intraluminal trinitrobenzenesulfonic acid." | 3.68 | Nitric oxide release in response to gut injury. ( Bustamante, SA; Chotinaruemol, S; Clark, DA; McIntyre, JA; Miller, MJ; Sadowska-Krowicka, H; Zhang, XJ, 1993) |
| "Aluminum chloride treatment significantly caused cognitive dysfunction and mitochondria oxidative damage as compared to vehicle treated control group." | 2.78 | Naringin protects memory impairment and mitochondrial oxidative damage against aluminum-induced neurotoxicity in rats. ( Kumar, A; Prakash, A; Shur, B, 2013) |
| " A decrease in the production and bioavailability of NO is a hallmark of many major chronic diseases including hypertension, ischaemia-reperfusion injury, atherosclerosis and diabetes." | 2.53 | Therapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases. ( Lundberg, JO; Omar, SA; Webb, AJ; Weitzberg, E, 2016) |
| "Growing evidence indicates that exposure to high levels of nitrite for a prolonged time has adverse health effects." | 1.72 | Gut microbiota mediated the toxicity of high concentration of dietary nitrite in C57BL/6 mice. ( He, Z; Lin, X; Liu, Q; Pu, K; Wang, M; Xu, J, 2022) |
| "Dietary nitrite suppressed liver fibrosis in the rats by reducing oxidative stress, as measured using the protein levels of nicotinamide adenine dinucleotide phosphate oxidase components and inflammatory cell accumulation in the liver." | 1.72 | Beneficial Effects of Dietary Nitrite on a Model of Nonalcoholic Steatohepatitis Induced by High-Fat/High-Cholesterol Diets in SHRSP5/Dmcr Rats: A Preliminary Study. ( Kasono, K; Kitamori, K; Kobayashi, J; Kono, Y; Ohtake, K; Shiba, S; Sonoda, K, 2022) |
| "Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection." | 1.72 | Lung-Brain Crosstalk in Sepsis: Protective Effect of Prophylactic Physical Exercise Against Inflammation and Oxidative Stress in Rats. ( Bagio, E; Bonfante, S; Cardoso, T; Dacoregio, C; Danielski, LG; de Souza Goldim, MP; Giustina, AD; Joaquim, L; Machado, RS; Mathias, K; Petronilho, F; Pinho, RA; Predroso, GS; Rodrigues, JF; Silveira, PCL; Stork, S; Venturini, LM; Zaccaron, RP; Zarbato, G, 2022) |
| "Seizures were induced by pentylenetetrazol and maximal electroshock." | 1.72 | Opioidergic and nitrergic systems mediate the anticonvulsant effect of mefloquine and chloroquine on seizures induced by pentylenetetrazol and maximal electroshock in mice. ( Boroujeni, SS; Dehpour, AR; Jafari, RM; Karimi, E; Maleki, A; Mohammadi, P; Sabzevari, O; Shafaroodi, H; Solaimanian, S, 2022) |
| "Bronchial asthma is a chronic lung disorder, that affects an estimated 262 million people worldwide, thereby, causing a large socio-economic burden." | 1.72 | Orally administered solasodine, a steroidal glycoalkaloid, suppresses ovalbumin-induced exaggerated Th2-immune response in rat model of bronchial asthma. ( Arora, P; Chellappan, DK; Dua, K; Gupta, G; Nainwal, LM; Oliver, BG; Singh, SK, 2022) |
| "Amphotericin B is a well-established pharmacologically approved drug; however, mainly toxicity is a foremost issue with that drug." | 1.62 | Synergic effect of eugenol oleate with amphotericin B augments anti-leishmanial immune response in experimental visceral leishmaniasis in vitro and in vivo. ( Charan Raja, MR; Debnath, J; Jayaraman, A; Kar, A; Mahapatra, SK; Srinivasan, S, 2021) |
| "The hypothesis of decreased nitric oxide (NO) bioavailability in sickle cell disease (SCD) proposes that multiple factors leading to decreased NO production and increased consumption contributes to vaso-occlusion, pulmonary hypertension, and pain." | 1.56 | Sickle cell disease subjects and mouse models have elevated nitrite and cGMP levels in blood compartments. ( Almeida, LEF; Darbari, DS; de Souza Batista, CM; Finkel, JC; Kamimura, S; Nettleton, MY; Quezado, ZMN; Smith, ML; Spornick, N; Wakim, P; Walek, E, 2020) |
| "Amantadine treatment also reduces the production of NO and metabolism of GABA." | 1.56 | Amantadine exerts anxiolytic like effect in mice: Evidences for the involvement of nitrergic and GABAergic signaling pathways. ( Garg, C; Garg, M; Walia, V, 2020) |
| "domestica on ulcerative colitis induced by acetic acid in rats." | 1.56 | Effect of Sorbus domestica and its active constituents in an experimental model of colitis rats induced by acetic acid. ( Gürağaç Dereli, FT; Khan, H; Küpeli Akkol, E; Sobarzo-Sánchez, E; Taştan, H, 2020) |
| "Vinpocetine ameliorated the Aβ-infused memory deficits in both MWM and PAL tests." | 1.56 | The protective and therapeutic effects of vinpocetine, a PDE1 inhibitor, on oxidative stress and learning and memory impairment induced by an intracerebroventricular (ICV) injection of amyloid beta (aβ) peptide. ( Komaki, A; Raoufi, S; Salehi, I; Sarihi, A; Shahidi, S; Shekarian, M, 2020) |
| "Parkinson's disease is a neurodegenerative disorder that affects the central nervous system and is mainly characterized by the loss of dopaminergic neurons and pro-oxidant mechanisms." | 1.56 | Eugenol and its association with levodopa in 6-hydroxydopamine-induced hemiparkinsonian rats: Behavioural and neurochemical alterations. ( Aragão Catunda Junior, FE; Basto Souza, R; da Cunha Ferreira, NM; de Sousa Dos Reis, TD; Hardy Lima Pontes, N; Maranguape Silva da Cunha, R; Moreira Vasconcelos, CF; Vasconcelos Aguiar, LM, 2020) |
| "Levosimendan was administered after ROSC with a loading dose of 10 μg/kg and then infused at 0." | 1.56 | Synergistic Effects of Moderate Therapeutic Hypothermia and Levosimendan on Cardiac Function and Survival After Asphyxia-Induced Cardiac Arrest in Rats. ( Chang, WT; Chen, WJ; Huang, CH; Tsai, MS; Wang, CH, 2020) |
| "Maternal undernutrition is known to reduce glomerular number but it may also affect tubulointerstitium, capillary density, and response to oxidative stress." | 1.51 | Maternal undernutrition aggravates renal tubular necrosis and interstitial fibrosis after unilateral ureteral obstruction in male rat offspring. ( Abe, T; Awazu, M; Hashiguchi, A; Hida, M, 2019) |
| " Obtained findings suggested that CLE was able to enhance nitric oxide bioavailability that might dampen the vasoconstriction effect of phenylephrine." | 1.51 | Effects of citrus leaf extract on aortic vascular reactivity in hypertensive rats fed repeatedly heated vegetable oil. ( Jaarin, K; Kamisah, Y; Mohamed, S; Siti, HN, 2019) |
| "Lycopene was able to minimize redox processes by decreasing lipid peroxidation and DNA damage, and by having an increase in the activities of SOD, CAT and GSH content." | 1.51 | Lycopene mitigates pulmonary emphysema induced by cigarette smoke in a murine model. ( Bezerra, FS; Campos, KKD; Cangussú, SD; Costa, DC; Costa, GP; de Oliveira Ramos, C; Garcia, CCM; Martins, TL; Oliveira, LAM; Talvani, A, 2019) |
| " Quercetin (QC) in combination with piperine (bioenhancer) acts as potential antioxidant, anti-inflammatory and neuroprotective against 6-OHDA rat model of PD." | 1.48 | Piperine in combination with quercetin halt 6-OHDA induced neurodegeneration in experimental rats: Biochemical and neurochemical evidences. ( Kumar, P; Singh, S, 2018) |
| "Ischemia was followed by a significant increase in muscle myeloperoxidase activity, as well as interleukin-6 and thiobarbituric acid reactive substances species levels." | 1.48 | N-acetylcysteine effects on a murine model of chronic critical limb ischemia. ( Constantino, L; da Silva, LA; Dal-Pizzol, F; Dall'Igna, DM; de Medeiros, WA; Dos Santos Cardoso, J; Manfredini, A; Michels, M; Ritter, C; Scaini, G; Streck, EL; Vuolo, F, 2018) |
| "Mild hyperhomocysteinemia is considered a risk factor for development of neurodegenerative diseases." | 1.48 | Chronic Mild Hyperhomocysteinemia Alters Inflammatory and Oxidative/Nitrative Status and Causes Protein/DNA Damage, as well as Ultrastructural Changes in Cerebral Cortex: Is Acetylsalicylic Acid Neuroprotective? ( de S Moreira, D; Figueiró, PW; Guma, FCR; Manfredini, V; Prezzi, CA; Rohden, F; Siebert, C; Wyse, ATS, 2018) |
| "Dimethyl fumarate (DMF) is an important agent against inflammatory response and reactive species in CNS disorders." | 1.48 | Dimethyl Fumarate Limits Neuroinflammation and Oxidative Stress and Improves Cognitive Impairment After Polymicrobial Sepsis. ( Barichello, T; da Rosa, N; Danielski, LG; de Oliveira Junior, AN; de Souza Goldim, MP; Florentino, D; Fortunato, JJ; Giustina, AD; Gomes, ML; Laurentino, AO; Mathias, K; Moreira, AP; Petronilho, F; Schuck, PF; Steckert, AV; Trombetta, T; Zarbato, GF, 2018) |
| "Body weight was measured weekly." | 1.48 | Effect of long-term nitrite administration on browning of white adipose tissue in type 2 diabetic rats: A stereological study. ( Abdollahifar, MA; Ghasemi, A; Haeri Rohani, SA; Jeddi, S; Piryaei, A; Varzandi, T; Zadeh-Vakili, A, 2018) |
| "Both the incidence and prevalence of ulcerative colitis (UC) are increasing throughout the world." | 1.48 | Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis. ( Chen, X; Guo, Y; Min, X; Pei, L; Wu, X, 2018) |
| "Sickle cell disease is caused by a mutant form of hemoglobin that polymerizes under hypoxic conditions, increasing rigidity, fragility, calcium influx-mediated dehydration, and adhesivity of red blood cells." | 1.46 | Potential therapeutic action of nitrite in sickle cell disease. ( Alexander-Miller, MA; Basu, S; Bolden, CA; Buechler, NL; Caudell, DL; Gladwin, MT; Jailwala, A; Kim, HW; Kim-Shapiro, DB; Ostrowski, D; Perlegas, A; Rahbar, E; Vachharajani, V; Wajih, N, 2017) |
| " This study aimed to investigate the effects of mirtazapine (MIRT) alone and combined with alpha-lipoic acid (ALA) against corticosterone (CORT) induced behavioral and oxidative alterations." | 1.46 | Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone. ( de Oliveira, AA; de Sousa, CNS; de Sousa, LC; Honório Júnior, JER; Macedo, D; Maes, M; Medeiros, IDS; Oliveira, TQ; Patrocínio, CFV; Vasconcelos, GS; Vasconcelos, SMM, 2017) |
| "Nitroxyl anion (HNO) has recently become an emerging candidate in vascular regulation." | 1.46 | Nitroxyl Anion Mediates Relaxation in Mesenteric Arteries from Angiotensin II Hypertensive Mice. ( Labazi, H; Tostes, RC; Webb, RC; Wynne, BM, 2017) |
| "Sepsis was induced in male Wistar rats by cecal ligation and puncture (CLP)." | 1.46 | Nitrite administration improves sepsis-induced myocardial and mitochondrial dysfunction by modulating stress signal responses. ( Hayashi, S; Hirata, N; Inoue, S; Kawaguchi, R; Tokinaga, Y; Watanabe, N; Yamakage, M, 2017) |
| "Colitis was induced by intrarectal (i." | 1.43 | Behavioral despair associated with a mouse model of Crohn's disease: Role of nitric oxide pathway. ( Abbasi, A; Dehpour, AR; Fakhfouri, G; Fakhraei, N; Ghia, JE; Heydarpour, P; Khoshkish, S; Rahimian, R; Salehi-Sadaghiani, M; Wang, H, 2016) |
| "Arterial thrombosis was induced electrically in rats with renovascular hypertension by partial ligation of the left renal artery." | 1.43 | Role of xanthine oxidoreductase in the anti-thrombotic effects of nitrite in rats in vivo. ( Buczko, W; Chabielska, E; Chlopicki, S; Kaminski, T; Kramkowski, K; Leszczynska, A; Proniewski, B; Przyborowski, K; Rykaczewska, U; Sitek, B; Smolenski, RT; Zakrzewska, A, 2016) |
| "Chloroquine has long been used for the treatment of malaria and rheumatological disorders." | 1.43 | Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice. ( Abkhoo, A; Amiri, S; Boojar, MM; Dehpour, AR; Delazar, S; Hassanipour, M; Ostadhadi, S; Rahimi, N; Shirzadian, A, 2016) |
| "Fragile X syndrome is the most common genetic cause of mental disability." | 1.43 | An Abnormal Nitric Oxide Metabolism Contributes to Brain Oxidative Stress in the Mouse Model for the Fragile X Syndrome, a Possible Role in Intellectual Disability. ( Calvo-Medina, R; de Diego-Otero, Y; el Bekay, R; Garcia-Guirado, F; Lima-Cabello, E; Perez-Costillas, L; Quintero-Navarro, C; Sanchez-Salido, L, 2016) |
| "Acute kidney injury is usually associated with distant organ dysfunction." | 1.43 | Distant effects of unilateral renal ischemia/reperfusion on contralateral kidney but not lung in rats: the roles of ROS and iNOS. ( Fatemikia, H; Karimi, Z; Ketabchi, F; Moosavi, SM, 2016) |
| "Neonatal anoxia arises due to oxygen deprivation at the time of birth and results in life long neurodevelopmental deficits and sometimes may lead to death." | 1.43 | Neonatal anoxia leads to time dependent progression of mitochondrial linked apoptosis in rat cortex and associated long term sensorimotor deficits. ( Krishnamurthy, S; Kumar, A; Narayan, G; Samaiya, PK, 2016) |
| "Con A hepatitis is regarded as a T cell-mediated model of acute liver injury." | 1.43 | Mincle Signaling Promotes Con A Hepatitis. ( Barilla, R; Daley, D; Deutsch, M; Gelb, BE; Greco, SH; Gutierrez, J; Hundeyin, M; Kalabin, A; Katz, SC; Mani, VR; Miller, G; Nagaraj, SV; Nikifrov, Y; Ochi, A; Ravirala, S; Rokosh, R; Salyana, MA; Seifert, L; Tejada, K; Torres-Hernandez, A; Whiteman, C, 2016) |
| "Acute and subacute administration of zinc exert neuroprotective effects in hypoxia-ischemia animal models; yet the effect of chronic administration of zinc still remains unknown." | 1.43 | Prophylactic Chronic Zinc Administration Increases Neuroinflammation in a Hypoxia-Ischemia Model. ( Aguilar-Carrasco, LA; Aguilar-Peralta, AK; Blanco-Alvarez, VM; Brambila, E; Cebada, J; Garate-Morales, JL; Garcia-Robles, G; Gonzalez-Barrios, JA; Gonzalez-Vazquez, A; Leon-Chavez, BA; Limón, DI; Martinez-Fong, D; Soto-Rodriguez, G; Tomas-Sanchez, C; Torres-Soto, M, 2016) |
| " Further studies evaluating longer-duration nitrite therapy and/or additional nitrite dosing strategies are warranted to more fully evaluate the therapeutic potential of nitrite therapy in peripheral vascular disease." | 1.42 | Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome. ( Bradley, JM; Brewster, LP; Calvert, JW; Chang, CC; Goodchild, TT; Islam, KN; Lefer, DJ; Pipinos, II; Polhemus, DJ; Tao, YX, 2015) |
| "5 improved most of the parameters evaluated in this study without causing motor impairment demonstrating, thus, that possibly when combined with ALA a lower dose of CLZ is required." | 1.42 | Alpha-lipoic acid alone and combined with clozapine reverses schizophrenia-like symptoms induced by ketamine in mice: Participation of antioxidant, nitrergic and neurotrophic mechanisms. ( de Lucena, DF; de Sousa, CN; Gama, CS; Lima, LL; Macêdo, D; Oliveira, Tde Q; Vasconcelos, GS; Vasconcelos, SM; Ximenes, NC, 2015) |
| "Hypertension is a common disease that includes oxidative stress as a major feature, and oxidative stress impairs physiological nitric oxide (NO) activity promoting cardiovascular pathophysiological mechanisms." | 1.42 | Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension. ( Amaral, JH; Ferreira, GC; Montenegro, MF; Pinheiro, LC; Tanus-Santos, JE, 2015) |
| "The experimental model of pleurisy was induced in mice by a single intrapleural injection of carrageenan (1 %)." | 1.40 | Croton antisyphiliticus Mart. attenuates the inflammatory response to carrageenan-induced pleurisy in mice. ( de Carvalho, FK; Dos Reis, GO; Fröde, TS; Heller, M; Micke, GA; Pizzolatti, MG; Vicente, G, 2014) |
| "Colitis was induced in mice by administrating dextran sulfate sodium (DSS) with concurrent administration of nitrite (1 mM) or nitrate (10 mM) in the drinking water for 7 days." | 1.40 | Preventive and therapeutic effects of nitrite supplementation in experimental inflammatory bowel disease. ( Borniquel, S; Holm, L; Jädert, C; Lundberg, JO; Phillipson, M, 2014) |
| "Spinal cord trauma is a major cause of mortality and morbidity." | 1.40 | Hyperbaric oxygen treatment in the experimental spinal cord injury model. ( Aydın, F; Temiz, C; Var, A; Yaman, B; Yaman, O, 2014) |
| "Chromatolysis and amyloid plaques were found along with higher ROS, nitrite and TNF-α levels in the hippocampus of colchicine-induced AD rats, and these changes were prevented by naproxen in a dose-dependent manner." | 1.40 | Effects of naproxen on immune responses in a colchicine-induced rat model of Alzheimer's disease. ( Dutta, G; Ghosh, T; Goswami, AR; Sil, S, 2014) |
| "Procarbazine (P) is an effective chemotherapeutic drug especially used in lymphoma treatment; however testicular toxicity is a limiting factor." | 1.40 | The effect of melatonin on procarbazine induced testicular toxicity on rats. ( Akgül, EÖ; Alp, BF; Babacan, O; Erdem, O; Gulgun, M; Kesik, V; Korkmazer, N; Malkoç, E; Poyrazoglu, Y; Saldır, M; Yiğit, N, 2014) |
| "Honokiol (HNK) is a biphenolic neolignan possessing multiple biological activities including antioxidant, anti-inflammatory, anxiolytic, antidepressant and neuroprotective." | 1.40 | Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice. ( Baruah, CC; Dwivedi, S; Hazarika, NK; Jangra, A; Kumar, P; Lahkar, M; Sulakhiya, K, 2014) |
| "Mechanical hyperalgesia was evaluated using a modified Randall and Selitto method in rats, cytokine production by ELISA and nitroxyl was determined by confocal microscopy in DAF (a cell permeable reagent that is converted into a fluorescent molecule by nitrogen oxides)-treated dorsal root ganglia neurons in culture." | 1.39 | The nitroxyl donor, Angeli's salt, inhibits inflammatory hyperalgesia in rats. ( Casagrande, R; Cunha, FQ; Cunha, TM; Ferreira, SH; Marchesi, M; Miranda, KM; Pinge-Filho, P; Schivo, IR; Souza, GR; Verri, WA; Zarpelon, AC, 2013) |
| "Mortality of patients with acute liver failure (ALF) is still unacceptably high." | 1.39 | Evaluation of the Hepa Wash® treatment in pigs with acute liver failure. ( Al-Chalabi, A; Huber, W; Kreymann, B; Luppa, P; Matevossian, E; Nairz, E; Neiss, A; Perren, A; Radermacher, P; Schimmel, P; Schmid, RM; Schreiber, C; Schuster, T; V Thaden, AK; Yang, Z, 2013) |
| "Curcumin pretreatment can attenuate seizures, lower some oxidative stress markers, and prevent hippocampal neuronal loss and MFS in the kainate-induced model of TLE." | 1.39 | Antiepileptogenic effect of curcumin on kainate-induced model of temporal lobe epilepsy. ( Baluchnejadmojarad, T; Khalili, M; Kiasalari, Z; Rahmati, B; Roghani, M, 2013) |
| "Various potential molecules with putative positive role in stroke pathology have failed to confer neuro-protection in animal models due to their insufficient bioavailability in brain." | 1.39 | Verapamil augments the neuroprotectant action of berberine in rat model of transient global cerebral ischemia. ( Chopra, K; Singh, DP, 2013) |
| "Aliskiren treatment, either concurrent or subsequent, elevated plasma NO(2) levels and reduced systolic hypertension, insulin resistance, dyslipidemia, aortic lipid peroxide levels and aortic wall hypertrophy in FHR." | 1.39 | Direct renin inhibitor prevents and ameliorates insulin resistance, aortic endothelial dysfunction and vascular remodeling in fructose-fed hypertensive rats. ( Chou, CL; Fang, TC; Lee, TJ; Pang, CY, 2013) |
| "Muscimol was administered twice on d14 and twice on d15 (1 h prior to each lipopolysaccharide injection; 0." | 1.39 | Muscimol delays lipopolysaccharide-induced preterm delivery in mice: role of GABA(A) receptors and nitric oxide. ( Dehpour, AR; Fakhraei, N; Gharedaghi, MH; Javadi-Paydar, M; Javadian, P; Salehi-Sadaghiani, M; Tavangar, SM; Yousefzadeh-Fard, Y, 2013) |
| "In a mouse model of LPS-induced septic shock, TCC inhibited the production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, and increased survival by 83%." | 1.39 | The aerial part of Taraxacum coreanum extract has an anti-inflammatory effect on peritoneal macrophages in vitro and increases survival in a mouse model of septic shock. ( Bu, Y; Choi, HY; Ham, I; Kang, H; Kim, H; Lee, K; Lee, MH; Yang, G, 2013) |
| "Hypertension is a disorder affecting millions worldwide, and is a leading cause of death and debilitation in the United States." | 1.38 | Aorta from angiotensin II hypertensive mice exhibit preserved nitroxyl anion mediated relaxation responses. ( Labazi, H; Tostes, RC; Webb, RC; Wynne, BM, 2012) |
| "Ischemia is a major factor contributing to failure of skin flap surgery, which is routinely used for coverage of wounds to prevent infection and to restore form and function." | 1.38 | Polydeoxyribonucleotide restores blood flow in an experimental model of ischemic skin flaps. ( Altavilla, D; Bitto, A; Calò, M; Galeano, M; Irrera, N; Marini, H; Polito, F; Squadrito, F, 2012) |
| "Acute lung injury is still a significant clinical problem with a high mortality rate and there are few effective therapies in clinic." | 1.38 | Ruscogenin inhibits lipopolysaccharide-induced acute lung injury in mice: involvement of tissue factor, inducible NO synthase and nuclear factor (NF)-κB. ( Chen, L; Gao, M; Jiang, W; Kou, J; Li, J; Shao, F; Sun, Q; Wang, J; Yu, B, 2012) |
| "Sodium nitrite treatment reduced SBP in 2K1C rats (P < 0." | 1.38 | Antihypertensive and antioxidant effects of a single daily dose of sodium nitrite in a model of renovascular hypertension. ( Amaral, JH; Costa-Filho, AJ; Marçal, DM; Montenegro, MF; Palei, AC; Pinheiro, LC; Tanus-Santos, JE, 2012) |
| "Acute lung injury was associated with a higher degree of pulmonary HIF-1α and iNOS expression as well as apoptosis in the lungs." | 1.38 | Inhibition of hypoxia inducible factor-1α ameliorates lung injury induced by trauma and hemorrhagic shock in rats. ( Hu, R; Huang, Y; Jiang, H; Li, QF; Xu, H, 2012) |
| "All animals underwent right middle cerebral artery occlusion (MCAO) for 2 h." | 1.38 | Noninvasive limb remote ischemic preconditioning contributes neuroprotective effects via activation of adenosine A1 receptor and redox status after transient focal cerebral ischemia in rats. ( Chen, S; Dong, H; Hou, L; Hu, S; Wang, S; Xiong, L; Zhang, H; Zhang, J, 2012) |
| " Nitrite administration to CS rats restored nitric oxide bioavailability by enhancing nitrite levels of the muscle, resulting in a reduction of rhabdomyolysis markers such as potassium, lactate dehydrogenase, and creatine phosphokinase." | 1.38 | Nitrite reduces ischemia/reperfusion-induced muscle damage and improves survival rates in rat crush injury model. ( Inoue, Y; Kanamoto, I; Kimura, S; Kobayashi, J; Morimoto, Y; Murata, I; Nakano, G; Nozaki, R; Ohtake, K; Ooi, K; Sonoda, K; Uchida, H; Ueda, H, 2012) |
| " Among the causative factors of BBB disruption are accelerating peroxynitrite formation and the resultant decreased bioavailability of nitric oxide (NO)." | 1.38 | The inhibitory effect of S-nitrosoglutathione on blood-brain barrier disruption and peroxynitrite formation in a rat model of experimental stroke. ( Dhammu, TS; Gilg, AG; Khan, M; Sakakima, H; Shunmugavel, A; Singh, AK; Singh, I, 2012) |
| "Cepharanthine (CE) is a plant alkaloid that possesses bioactive properties, with various known actions." | 1.37 | Cepharanthine exerts anti-inflammatory effects via NF-κB inhibition in a LPS-induced rat model of systemic inflammation. ( Hagiwara, S; Hasegawa, A; Koga, H; Kudo, K; Kusaka, J; Noguchi, T, 2011) |
| "Heat stroke is a condition characterized by high body temperature that can lead to hemorrhage and necrosis in multiple organs." | 1.37 | Danaparoid sodium attenuates the effects of heat stress. ( Hagiwara, S; Iwasaka, H; Matsumoto, S; Mizunaga, S; Nishida, T; Noguchi, T; Saikawa, T; Shingu, C; Uchida, T, 2011) |
| "Huntington disease is a neurodegenerative disease with complex pathophysiology." | 1.37 | Attenuation of proinflammatory cytokines and apoptotic process by verapamil and diltiazem against quinolinic acid induced Huntington like alterations in rats. ( Kalonia, H; Kumar, A; Kumar, P, 2011) |
| "Rofecoxib is a selective cyclooxygenase 2 enzymes belongs to non-steroidal anti-inflammatory drug, commonly called as coxibs." | 1.37 | Galantamine potentiates the protective effect of rofecoxib and caffeic acid against intrahippocampal Kainic acid-induced cognitive dysfunction in rat. ( Kumar, A; Pahwa, D; Prakash, A, 2011) |
| "Impaired wound healing in diabetes is associated with decreased nitric oxide (NO) bioavailability in wound tissue." | 1.37 | Azelnidipine, a new calcium channel blocker, promotes skin wound healing in diabetic rats. ( Amirghofran, Z; Bagheri, M; Jahromi, BM; Mirkhani, H; Noorafshan, A; Solhjou, Z; Zamani, A, 2011) |
| "Ocular hypertension was induced by unilaterally cauterizing three episcleral vessels and the unoperated eye served as control." | 1.37 | Manganese porphyrin reduces retinal injury induced by ocular hypertension in rats. ( Aslan, M; Batinic-Haberle, I; Cort, A; Dogan, S; Ozturk, N; Spasojevic, I; Unal, M; Yargicoglu, P, 2011) |
| " Catechin (50 mg/Kg) was co-supplemented after 4 weeks of alcohol treatment till the end of the dosing period." | 1.37 | Catechin suppresses an array of signalling molecules and modulates alcohol-induced endotoxin mediated liver injury in a rat model. ( Bharrhan, S; Chopra, K; Koul, A; Rishi, P, 2011) |
| "The pathogenesis of nonalcoholic steatohepatitis (NASH) is still unclear." | 1.36 | Nitric oxide plays a crucial role in the development/progression of nonalcoholic steatohepatitis in the choline-deficient, l-amino acid-defined diet-fed rat model. ( Fujita, K; Inamori, M; Iwasaki, T; Kirikoshi, H; Maeyama, S; Nakajima, A; Nozaki, Y; Saito, S; Takahashi, H; Terauchi, Y; Wada, K; Yoneda, M, 2010) |
| " Our data suggest that the effect of the sex of the animal on NOS activity and expression is different in the three regions of the SHR kidney and supports the hypothesis that male SHR have lower NO bioavailability compared with females." | 1.36 | Renal NOS activity, expression, and localization in male and female spontaneously hypertensive rats. ( Hyndman, KA; Pardieck, JL; Pollock, JS; Sullivan, JC, 2010) |
| "Astaxanthine treatment significantly decreased hepatic conversion of XDH to XO and tissue protein carbonyl levels following IR injury." | 1.36 | Effect of astaxanthin on hepatocellular injury following ischemia/reperfusion. ( Aslan, M; Cort, A; Curek, GD; Demir, N; Elpek, GO; Ozturk, S; Savas, B; Yucel, G, 2010) |
| "CCD rats showed thermal hyperalgesia and increased nitrite production." | 1.36 | Involvement of TRPV4-NO-cGMP-PKG pathways in the development of thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats. ( Ding, XL; Ge, HY; Jiang, H; Ning, LP; Wang, R; Wang, YH; Yue, SW; Zhang, Y, 2010) |
| "Post-treatment with magnolol significantly attenuated the deleterious haemodynamic changes (e." | 1.36 | Beneficial effects of magnolol in a rodent model of endotoxin shock. ( Cheng, PY; Ke, TH; Kung, CW; Peng, YJ; Tsai, YC; Wang, JJ; Yen, MH, 2010) |
| "Indomethacin treatment significantly decreased cotton pellet implantation induced white blood cell count elevation and immune cells infiltration in epididymal white adipose tissue." | 1.36 | Indomethacin activates peroxisome proliferator-activated receptor γ to improve insulin resistance in cotton pellet granuloma model. ( Chen, W; Cheng, JT; Cheng, KC; Shen, KH; Wu, HT; Yeh, CH, 2010) |
| "Quercetin treatment restored plasma nitrite and nitroso species levels to those found in the sham-vehicle group (P < 0." | 1.36 | Quercetin restores plasma nitrite and nitroso species levels in renovascular hypertension. ( Castro, MM; Ceron, CS; Dias-Junior, CA; Gomes, VA; Kanashiro, A; Montenegro, MF; Neto-Neves, EM; Tanus-Santos, JE, 2010) |
| "Quinolinic acid has been reported to induce excitotoxicity by stimulating the N-methyl-D-aspartate receptor, causing calcium overload which in turn leads to the neurodegeneration." | 1.36 | Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: possible behavioral, biochemical, mitochondrial and tumor necrosis factor-α level alterations in rats. ( Kalonia, H; Kumar, A; Kumar, P; Nehru, B, 2010) |
| "Allergen-induced lung inflammation was potentiated in mice with elevated circulating ADMA and was reduced in mice overexpressing DDAH." | 1.36 | Asymmetric dimethylarginine potentiates lung inflammation in a mouse model of allergic asthma. ( Buford, MC; Holian, A; Klein, E; Weigel, J; Wells, SM, 2010) |
| "Although trauma-hemorrhage produces tissue hypoxia, systemic inflammatory response and organ dysfunction, the mechanisms responsible for these alterations are not clear." | 1.35 | Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation-induced hepatic injury. ( Bland, KI; Chaudry, IH; Choudhry, MA; Hsu, JT; Kan, WH; Raju, R; Schwacha, MG, 2008) |
| "Inflammation is a typical reaction to infection." | 1.35 | Hyperthermia amplifies brain cytokine and reactive oxygen species response in a model of perinatal inflammation. ( Dow, KE; Flavin, MP; Wang, W, 2008) |
| "Smoke inhalation injury is often complicated with pneumonia, which frequently leads to subsequent development of sepsis." | 1.35 | Role of neuronal nitric oxide synthase in ovine sepsis model. ( Enkhbaatar, P; Hamahata, A; Herndon, D; Jaroch, S; Jonkam, C; Lange, M; Nakano, Y; Traber, D; Traber, L; Wang, J, 2009) |
| "Hypercholesterolemia is a major risk factor for the development and progression of cardiovascular diseases including atherosclerosis." | 1.35 | Suppression of diet-induced hypercholesterolemia by scutellarin in rats. ( Chan, SW; Chen, SL; Cheng, HL; Guo, DJ; Li, Q; Wu, JH, 2009) |
| "An experimental model of chronic fatigue syndrome (CFS) is utilized for evaluation of antidepressant, anti-stress effects, wherein the rat is forced to swim in water for 15 min/day on 21 consecutive days." | 1.35 | The role of antioxidant properties of Nardostachys jatamansi in alleviation of the symptoms of the chronic fatigue syndrome. ( Bhattacharyya, D; Chatterjee, S; Gomes, A; Lyle, N; Munshi, S; Paul, S; Sur, T, 2009) |
| "Hyperglycemia is frequently observed in nondiabetic patients during acute illness." | 1.35 | Hyperglycemia contributes to cardiac dysfunction in a lipopolysaccharide-induced systemic inflammation model. ( Asai, N; Hagiwara, S; Hasegawa, A; Iwasaka, H; Noguchi, T, 2009) |
| "Treatment with hesperidin showed a significant increase in tissue nitrite, antioxidant level and reduction in inflammation, arrhythmias and apoptosis." | 1.35 | Protection against in vivo focal myocardial ischemia/reperfusion injury-induced arrhythmias and apoptosis by hesperidin. ( Balaraman, R; Gandhi, C; Upaganalawar, A, 2009) |
| "Ozone treatment significantly reduced the severity of NEC by modulating antioxidative defense and antiinflammatory protection in our experimental animal model." | 1.35 | Medical ozone therapy reduces oxidative stress and intestinal damage in an experimental model of necrotizing enterocolitis in neonatal rats. ( Gundogdu, G; Guven, A; Korkmaz, A; Oztas, E; Ozturk, H; Uysal, B; Vurucu, S, 2009) |
| "Trauma/hemorrhagic shock (T/HS) results in cytokine-mediated acute inflammation that is generally considered detrimental." | 1.35 | An adequately robust early TNF-alpha response is a hallmark of survival following trauma/hemorrhage. ( Barclay, D; Billiar, TR; Clermont, G; Ghuma, A; Gomez, H; Gordon, L; Hermus, L; Kim, HK; Namas, R; Ochoa, J; Peitzman, A; Pinsky, MR; Polanco, P; Puyana, JC; Rosengart, MR; Torres, A; Vodovotz, Y; Zamora, R; Zenker, S, 2009) |
| "Atherosclerosis is enhanced in arterial segments exposed to disturbed flow." | 1.35 | Beneficial effects of low doses of red wine consumption on perturbed shear stress-induced atherogenesis. ( Balestrieri, ML; Crimi, E; D'Armiento, FP; De Rosa, G; Lerman, LO; Napoli, C; Schiano, C; Servillo, L; Sica, V, 2008) |
| "Biliary cirrhosis was accompanied with a decrease in baseline perfusion pressure in mesenteric vascular bed (P < 0." | 1.35 | Opioid receptor blockade improves mesenteric responsiveness in biliary cirrhosis. ( Dehpour, AR; Ebrahimkhani, MR; Kiani, S; Merat, S; Moezi, L, 2008) |
| " The results demonstrated that chronic administration of galanin improved the colon injury than the TNBS induced." | 1.34 | Chronic administration of galanin attenuates the TNBS-induced colitis in rats. ( Calvo, JR; Motilva, V; Sánchez-Fidalgo, S; Talero, E, 2007) |
| " In conclusion, our study suggests that chronic administration of celecoxib may have a damaging effect on kidney, as evident through altered histopathology and renal functions." | 1.34 | Role of oxidative stress in celecoxib-induced renal damage in wistar rats. ( Aggarwal, R; Agnihotri, N; Dutta, N; Gupta, S; Sarotra, P, 2007) |
| "Endotoxemia was induced by an infusion of lipopolysac-charide (LPS) after HDL or LDL administration." | 1.34 | High-density lipoprotein prevents organ damage in endotoxemia. ( Chao, YF; Chen, HI; Harn, HJ; Lee, RP; Lin, CC; Lin, NT, 2007) |
| "LPS induced cytotoxic brain swelling and maintained anatomical integrity of the blood-brain barrier." | 1.34 | Endotoxemia produces coma and brain swelling in bile duct ligated rats. ( Brooks, HF; Davies, C; Davies, NA; Harry, D; Hodges, SJ; Jalan, R; Mani, AR; Moore, KP; Shawcross, DL; Stadlbauer, V; Williams, R; Wright, G; Zou, Z; Zwingmann, C, 2007) |
| "Pyrrolidine dithiocarbamate treatment significantly reduced the MDA and NO levels, and increased the GSH levels in the lung parenchyma, biochemically (p < 0." | 1.34 | Pyrrolidine dithiocarbamate reduces lung injury caused by mesenteric ischemia/reperfusion in a rat model. ( Aytekin, FO; Bir, F; Erdem, E; Kabay, B; Ozden, A; Sacar, M; Teke, Z; Yenisey, C, 2007) |
| "Monosomy 21 is a rare human disease due to gene dosage errors disturbing a variety of physiological and morphological systems including brain, skeletal, immune and respiratory functions." | 1.34 | Modeling the monosomy for the telomeric part of human chromosome 21 reveals haploinsufficient genes modulating the inflammatory and airway responses. ( Besson, V; Bizot, JC; Brault, V; Duchon, A; Hérault, Y; Quesniaux, VF; Ryffel, B; Togbe, D, 2007) |
| "Melatonin was administered intraperitoneally with two different doses (20mg/kg or 40mg/kg) beginning 1h before HN2 application and continued every 12h for six replications." | 1.34 | Melatonin alleviates lung damage induced by the chemical warfare agent nitrogen mustard. ( Korkmaz, A; Kurt, B; Oter, S; Reiter, RJ; Topal, T; Ucar, M; Yaren, H, 2007) |
| " Intraperitoneal injection of 20% water solution of L-arginine in dosage 200 mg per 100 g of an animal body mass have had aggravated an acute pancreatitis course; intravenous injection of 1% water solution of methylene blue in dosage 1 mg per 100 g of an animal body mass caused pancreatoprotective effect." | 1.33 | [Role of nitric oxide and lipid peroxidation in pathogenesis of acute experimental pancreatitis]. ( Fedorovich, AA; Krivoruchko, IA, 2005) |
| "Sepsis was induced by intraperitoneal (i." | 1.33 | Role of oxidative stress in the pathogenesis of septic ileus in mice. ( Bredenoord, AJ; de Jonge, F; de Man, JG; de Winter, BY; Herman, AG; Pelckmans, PA; Seerden, TC; Timmermans, JP; van Nassauw, L, 2005) |
| "Rosiglitazone or 15d-PGJ2 were administered to rats 10 mins or 2 h after permanent middle cerebral artery occlusion (MCAO)." | 1.33 | Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms. ( Boscá, L; Cárdenas, A; Castillo, J; Dávalos, A; Hurtado, O; Lizasoain, I; Lorenzo, P; Moro, MA; Pereira, MP; Serena, J; Vivancos, J, 2006) |
| "Focal cerebral ischemia in rats was produced by permanent occlusion of right middle cerebral artery (MCAO)." | 1.33 | Effects of MK-801 on nitrite and cGMP levels during focal cerebral ischemia in rats. ( Balkan, E; Balkan, S; Gümüslü, S; Ozben, T; Serteser, M, 2005) |
| "Treatment with ibuprofen, either before or after ETX, partly restored the elevated levels of nitrite/nitrate." | 1.33 | Ibuprofen reduces plasma nitrite/nitrate levels in a rabbit model of endotoxin-induced shock. ( Akbulut, H; Ayar, A; Canbaz, M; Celik, I; Vural, P, 2005) |
| "CBDL rats show hypoxemia with intrapulmonary vasodilatation (IPVD), and are recognized as a model of hepatopulmonary syndrome (HPS), while PVL rats are normoxemic." | 1.33 | Arterial hypoxemia and intrapulmonary vasodilatation in rat models of portal hypertension. ( Akimoto, T; Kato, Y; Katsuta, Y; Komeichi, H; Miyamoto, A; Ohsuga, M; Satomura, K; Shimizu, S; Takano, T; Zhang, XJ, 2005) |
| "In a mouse model of platelet pulmonary thromboembolism, induced by the i." | 1.33 | A novel nitric oxide-releasing statin derivative exerts an antiplatelet/antithrombotic activity and inhibits tissue factor expression. ( Caracchini, R; Colucci, M; Giannini, S; Gresele, P; Guglielmini, G; Momi, S; Monopoli, A; Ongini, E; Rossiello, MR; Semeraro, N, 2005) |
| "Lower-limb ischemia is a major health problem." | 1.33 | Beneficial effects of concurrent autologous bone marrow cell therapy and metabolic intervention in ischemia-induced angiogenesis in the mouse hindlimb. ( Botti, C; Byrns, RE; de Nigris, F; de Rosa, G; Farzati, B; Fiore, A; Ignarro, LJ; Lerman, LO; Matarazzo, A; Napoli, C; Sica, G; Sica, V; Sumi, D; Williams-Ignarro, S, 2005) |
| "Hydroxyproline level was significantly higher (13." | 1.33 | Ginkgo biloba inhibits bleomycin-induced lung fibrosis in rats. ( Erdogan, H; Ermis, H; Fadillioğlu, E; Iraz, M; Kilic, T; Kotuk, M; Yağmurca, M; Yildirim, Z, 2006) |
| "Sildenafil attenuates acute pulmonary embolism (APE)-induced pulmonary hypertension." | 1.33 | Hemodynamic effects of sildenafil interaction with a nitric oxide donor compound in a dog model of acute pulmonary embolism. ( Dias-Junior, CA; Tanus-Santos, JE, 2006) |
| "Septic shock has a high mortality rate due to the hypotension and circulatory disorder that occurs during its pathogenesis." | 1.33 | Effects of verapamil and nifedipine on different parameters in lipopolysaccharide-induced septic shock. ( Erol, K; Kilic, FS; Sirmagul, B; Tunc, O; Yildirim, E, 2006) |
| "Sepsis is one of the common causes of acute renal failure (ARF)." | 1.33 | Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure. ( Dear, JW; Gladwin, MT; Hewitt, SM; Holly, MK; Hu, X; Schechter, AN; Star, RA; Yuen, PS, 2006) |
| "In vehicle-treated rats, Trypanosoma cruzi infection increased the cardiac levels of TNF-alpha, IFN-gamma and IL-10, at day 9 post inoculation, and the TNF-alpha remained elevated until day 13." | 1.33 | Blockade of endothelin ET(A)/ET(B) receptors favors a role for endothelin during acute Trypanosoma cruzi infection in rats. ( Barcellos, L; Camargos, ER; Chiari, E; Huang, H; Machado, CR; Marques, CA; Rachid, MA; Tanowitz, HB; Teixeira, MM, 2006) |
| " Besides, improving cognitive dysfunction, chronic administration of cyclooxygenase inhibitors (naproxen and valdecoxib) significantly reduced elevated malondialdehyde, nitrite levels and restored reduced glutathione levels and acetylcholinesterase activity." | 1.33 | Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats. ( Kumar, A; Naidu, PS; Padi, SV; Seghal, N, 2006) |
| "Proteinuria was significantly lower in L-arginine-treated animals from week 24 onward (p<0." | 1.32 | Long-term dietary L-arginine supplementation attenuates proteinuria and focal glomerulosclerosis in experimental chronic renal transplant failure. ( Albrecht, EW; Smit-van Oosten, A; Stegeman, CA; van Goor, H, 2003) |
| " In conclusion, the chronic use of NAC inhibited MPO activity and lipid peroxidation, which resulted in reduction of apoptosis in lung in this CLP model." | 1.32 | The protective effect of N-acetylcysteine on apoptotic lung injury in cecal ligation and puncture-induced sepsis model. ( Avlan, D; Cinel, I; Cinel, L; Dikmengil, M; Koksel, O; Okcu, H; Oral, U; Ozdulger, A; Unlu, A, 2003) |
| "Treatment with rosiglitazone enhanced PPARgamma expression, improved endothelium-dependent vasodilatation, preserved P-VASP, suppressed gp91phox and iNOS expression, reduced superoxide and total NOx production, and inhibited nitrotyrosine formation." | 1.32 | Antioxidative, antinitrative, and vasculoprotective effects of a peroxisome proliferator-activated receptor-gamma agonist in hypercholesterolemia. ( Batinic-Haberle, I; Christopher, TA; Gao, E; Liu, HR; Lopez, BL; Ma, XL; Ohlstein, EH; Tao, L; Teng, ZP; Willette, RN; Yue, TL, 2003) |
| " L-NAME treatment, applied at the dosage of 50 mg/kg/day, does not have any protective effect on the colonic injury." | 1.32 | Effects of intrarectal and intraperitoneal N(G)-nitro-L-arginine methyl ester treatment in 2,4,6-trinitrobenzenesulfonic acid induced colitis in rats. ( Angin, K; Dundar, E; Inal, M; Saricam, T; Vardareli, E, 2003) |
| "enalapril alone to enhance vascular effects, increase LV contractility and prevent unfavorable remodeling and are consistent with vascular delivery of exogenous NO." | 1.32 | A nitric oxide-releasing derivative of enalapril, NCX 899, prevents progressive cardiac dysfunction and remodeling in hamsters with heart failure. ( Condorelli, G; Del Soldato, P; Dieterle, T; Gu, Y; Iwanaga, Y; Ongini, E; Peterson, KL; Presotto, C; Ross, J, 2004) |
| "Pleurisy was induced by carrageenan (1%) treatment and the parameters were analyzed 4 and 48 h after." | 1.32 | Additional evidence of acute anti-inflammatory effects of cyclosporin A in a murine model of pleurisy. ( Fröde, TS; Medeiros, YS; Monguilhott Dalmarco, E, 2004) |
| "Sepsis is an acute inflammatory disease characterized by dysfunctional blood flow and hypotension." | 1.32 | Transduction of NO-bioactivity by the red blood cell in sepsis: novel mechanisms of vasodilation during acute inflammatory disease. ( Chacko, BK; Crawford, JH; Hogg, N; Patel, RP; Piknova, B; Pruitt, HM, 2004) |
| "Pleurisy was induced by intrapleural injection of carrageenan in mice pre-treated or not with PK11195." | 1.32 | Involvement of steroids in anti-inflammatory effects of PK11195 in a murine model of pleurisy. ( da Silva, MB; Farges, RC; Fröde, TS, 2004) |
| "Agmatine is a primary amine formed by the decarboxylation of L-arginine synthesized in mammalian brain." | 1.32 | Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury. ( Cho, SW; Giffard, RG; Kim, JH; Lee, JE; Park, KA; Yenari, MA, 2004) |
| "Quisqualic acid was injected into the right nucleus basalis of rats." | 1.31 | Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease. ( Casamenti, F; Pepeu, G; Prosperi, C; Scali, C; Vannucchi, MG, 2000) |
| "Both abdominal aortic aneurysms (AAAs) and inducible nitric oxide synthase (iNOS) are associated with inflammatory states, yet the relationship between NO production by iNOS and AAA development is unknown." | 1.31 | Inhibition of inducible nitric oxide synthase limits nitric oxide production and experimental aneurysm expansion. ( Carey, DJ; Elmore, JR; Franklin, DP; Han, DC; Johanning, JM, 2001) |
| "Cholestasis is associated with NO overproduction." | 1.31 | The role of the interaction between endogenous opioids and nitric oxide in the pathophysiology of ethanol-induced gastric damage in cholestatic rats. ( Akbari, MR; Dehpour, AR; Homayounfar, H; Mani, AR; Nahavandi, A, 2001) |
| "After 5 weeks, MRI showed right ventricular hypertrophy in MCT(+)/ACEI(-) rats." | 1.31 | Angiotensin-converting enzyme inhibitor preserves p21 and endothelial nitric oxide synthase expression in monocrotaline-induced pulmonary arterial hypertension in rats. ( Billiar, TR; Ho, C; Kanno, S; Lee, PC; Wu, YJ, 2001) |
| "Allodynia was also intensified by SNAP (5% or 30%) in rats pretreated with intraplantar 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ, 4 microg), a guanylate cyclase inhibitor." | 1.31 | Dual effect of local application of nitric oxide donors in a model of incision pain in rats. ( Cunha, FQ; Prado, WA; Schiavon, VF, 2002) |
| " Chronic administration of L-NAME to rats induced reduced NO production and hypertension in both strains of rats." | 1.31 | Chronic feeding of a nitric oxide synthase inhibitor induces postprandial hypertriglyceridemia in type 2 diabetic model rats, Otsuka Long-Evans Tokushima Fatty rats, but not in nondiabetic rats. ( Ishimura, N; Nakaya, Y; Takahashi, A; Takishita, E, 2002) |
| " Long-term administration (2 mo) of the selective NOS II inhibitor S-methylisothiourea (SMT) to rats with MI significantly improved cardiac function." | 1.31 | Inhibition of NOS II prevents cardiac dysfunction in myocardial infarction and congestive heart failure. ( Fahas, L; Giaid, A; Hu, F; Saito, T; Shennib, H; Tayara, L, 2002) |
| "Insulin dependent diabetes mellitus (IDDM) is an autoimmune disease characterised by extreme insulin deficiency due to an overall decrease in the mass of properly functioning beta-cells." | 1.30 | Insulitis and mechanisms of disease resistance: studies in an animal model of insulin dependent diabetes mellitus. ( Barley, J; Bone, AJ; Cunningham, JM; Gwilliam, DJ; Hitchcock, PR, 1999) |
| "085 DV." | 1.29 | Polydeoxyribonucleotides and nitric oxide release from guinea-pig hearts during ischaemia and reperfusion. ( Lupini, M; Mannaioni, PF; Masini, E; Mugnai, L; Raspanti, S, 1995) |
| "Using a murine respiratory influenza infection model, intranasally administered LIP-IFN-gamma conferred protection to 70% in mice challenged intranasally with 10 LD50 doses of influenza A/PR/8 virus compared with a 20% survival rate using free IFN-gamma." | 1.29 | Effect of liposome-encapsulation on immunomodulating and antiviral activities of interferon-gamma 1. ( Gorton, L; Kournikakis, B; Saravolac, EG; Wong, JP, 1996) |
| "Brain death was induced by inflation of a subdurally placed balloon and validated neuropathologically." | 1.29 | Nitric oxide in brain death related cardiovascular dysfunction. ( Bittner, HB; Chen, EP; Geiger, MI; Guice, KS; Kendall, SW; Van Trigt, P, 1996) |
| "Isobutyl nitrite was NK-cell-suppressive not only after in vivo administration but, most importantly, also after inhalation." | 1.27 | Depression of murine natural killer cell cytotoxicity by isobutyl nitrite. ( Hersh, EM; Khan, AA; Lotzová, E; Rosenblum, M; Savary, CA, 1984) |
| "The lead-induced renal neoplasms were histologically similar to those which occur spontaneously in man and, therefore, may serve as an animal model to study human disease." | 1.27 | Neoplasia induced in male rats fed lead acetate, ethyl urea, and sodium nitrite. ( Exon, JH; Kerkvliet, NI; Koller, LD, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (0.96) | 18.7374 |
| 1990's | 54 (8.64) | 18.2507 |
| 2000's | 249 (39.84) | 29.6817 |
| 2010's | 278 (44.48) | 24.3611 |
| 2020's | 38 (6.08) | 2.80 |
| Authors | Studies |
|---|---|
| Jang, G | 2 |
| Lee, S | 1 |
| Hong, J | 1 |
| Park, B | 1 |
| Kim, D | 1 |
| Kim, C | 1 |
| Kaviani, A | 1 |
| Khansari Nejad, N | 1 |
| Akour, A | 1 |
| AlMuhaissen, SA | 1 |
| Nusair, MB | 1 |
| Al-Tammemi, AB | 1 |
| Mahmoud, NN | 1 |
| Jalouqa, S | 1 |
| Alrawashdeh, MN | 1 |
| Shanahan, JP | 1 |
| Moore, CM | 1 |
| Kampf, JW | 1 |
| Szymczak, NK | 1 |
| Guo, J | 1 |
| Wang, H | 6 |
| Luo, Y | 1 |
| An, H | 1 |
| Zhang, Z | 4 |
| Liu, G | 1 |
| Li, J | 12 |
| Metcalfe, GD | 1 |
| Smith, TW | 1 |
| Hippler, M | 1 |
| Ayala Izurieta, JE | 1 |
| Márquez, CO | 1 |
| García, VJ | 1 |
| Jara Santillán, CA | 1 |
| Sisti, JM | 1 |
| Pasqualotto, N | 1 |
| Van Wittenberghe, S | 1 |
| Delegido, J | 1 |
| Kubo, Y | 1 |
| Kitagawa, Y | 1 |
| Miyazaki, T | 1 |
| Sohda, M | 1 |
| Yamaji, T | 1 |
| Sakai, M | 1 |
| Saeki, H | 1 |
| Nemoto, K | 1 |
| Oyama, T | 2 |
| Muto, M | 1 |
| Takeuchi, H | 1 |
| Toh, Y | 1 |
| Matsubara, H | 1 |
| Mano, M | 1 |
| Kono, K | 1 |
| Kato, K | 1 |
| Yoshida, M | 1 |
| Kawakubo, H | 1 |
| Booka, E | 1 |
| Yamatsuji, T | 1 |
| Kato, H | 2 |
| Ito, Y | 1 |
| Ishikawa, H | 1 |
| Ishihara, R | 1 |
| Tsushima, T | 1 |
| Kawachi, H | 1 |
| Kojima, T | 1 |
| Kuribayashi, S | 1 |
| Makino, T | 1 |
| Matsuda, S | 1 |
| Doki, Y | 1 |
| Ma, P | 1 |
| Tang, X | 1 |
| Zhang, L | 5 |
| Wang, X | 5 |
| Wang, W | 4 |
| Zhang, X | 9 |
| Wang, S | 4 |
| Zhou, N | 1 |
| Dodd, J | 1 |
| Jordan, R | 1 |
| Makhlina, M | 1 |
| Pesco Koplowitz, L | 1 |
| Koplowitz, B | 1 |
| Barnett, K | 1 |
| Yang, WH | 1 |
| Spana, C | 1 |
| Buchanan, SW | 1 |
| Mafa-Attoye, T | 1 |
| Dunfield, K | 1 |
| Thevathasan, NV | 1 |
| Isaac, ME | 1 |
| Wu, X | 5 |
| Huang, JW | 1 |
| Su, BK | 1 |
| Yuan, L | 1 |
| Zheng, WQ | 1 |
| Zhang, H | 5 |
| Zheng, YX | 1 |
| Zhu, W | 1 |
| Chou, PT | 1 |
| Manso, AP | 1 |
| De Morais, DC | 1 |
| Yamamoto, K | 1 |
| Owen, G | 1 |
| de Carvalho, RM | 1 |
| Palma-Dibb, RG | 1 |
| Brown, JC | 1 |
| Yang, S | 2 |
| Mire, EF | 1 |
| Miele, L | 1 |
| Ochoa, A | 1 |
| Zabaleta, J | 1 |
| Katzmarzyk, PT | 1 |
| Moi, CT | 1 |
| Bhowmick, S | 1 |
| Qureshi, M | 1 |
| Wang, K | 3 |
| Feng, B | 1 |
| Yang, Y | 5 |
| Chen, Y | 3 |
| Wang, Y | 14 |
| Yang, L | 1 |
| Jiang, K | 1 |
| James, TD | 1 |
| Chaturvedi, V | 1 |
| Postiglione, WM | 1 |
| Chakraborty, RD | 1 |
| Yu, B | 4 |
| Tabiś, W | 1 |
| Hameed, S | 1 |
| Biniskos, N | 1 |
| Jacobson, A | 1 |
| Zhou, H | 2 |
| Greven, M | 1 |
| Ferry, VE | 1 |
| Leighton, C | 1 |
| Wu, F | 2 |
| Lei, H | 2 |
| Chen, G | 1 |
| Chen, C | 1 |
| Song, Y | 2 |
| Cao, Z | 1 |
| Zhang, C | 5 |
| Zhou, J | 1 |
| Lu, Y | 2 |
| Pappone, C | 1 |
| Santinelli, V | 1 |
| Mecarocci, V | 1 |
| Tondi, L | 1 |
| Ciconte, G | 1 |
| Manguso, F | 1 |
| Sturla, F | 1 |
| Vicedomini, G | 1 |
| Micaglio, E | 1 |
| Anastasia, L | 1 |
| Pica, S | 1 |
| Camporeale, A | 1 |
| Lombardi, M | 1 |
| Shieh, PB | 1 |
| Elfring, G | 1 |
| Trifillis, P | 1 |
| Santos, C | 1 |
| Peltz, SW | 1 |
| Parsons, JA | 1 |
| Apkon, S | 1 |
| Darras, BT | 1 |
| Campbell, C | 2 |
| McDonald, CM | 1 |
| Galaviz, KI | 1 |
| Shah, NS | 1 |
| Gutierrez, M | 1 |
| Collins, LF | 1 |
| Lahiri, CD | 1 |
| Moran, CA | 1 |
| Szabo, B | 1 |
| Sumitani, J | 1 |
| Rhodes, J | 1 |
| Marconi, VC | 1 |
| Nguyen, ML | 1 |
| Cantos, VD | 1 |
| Armstrong, WS | 1 |
| Colasanti, JA | 1 |
| Park, S | 3 |
| Lee, KH | 1 |
| Choi, H | 1 |
| Kang, WS | 1 |
| Kim, E | 2 |
| Kim, JS | 5 |
| Na, CS | 1 |
| Kim, S | 4 |
| Xu, J | 4 |
| Wang, M | 1 |
| Liu, Q | 3 |
| Lin, X | 2 |
| Pu, K | 1 |
| He, Z | 4 |
| Suha, AJ | 1 |
| Sadr, SS | 1 |
| Roghani, M | 5 |
| Haftcheshmeh, SM | 1 |
| Khamse, S | 2 |
| Momtazi-Borojeni, AA | 1 |
| Sonoda, K | 4 |
| Kono, Y | 1 |
| Kitamori, K | 1 |
| Ohtake, K | 5 |
| Shiba, S | 1 |
| Kasono, K | 1 |
| Kobayashi, J | 5 |
| Giustina, AD | 2 |
| Rodrigues, JF | 1 |
| Bagio, E | 1 |
| Bonfante, S | 1 |
| Joaquim, L | 1 |
| Zarbato, G | 1 |
| Stork, S | 1 |
| Machado, RS | 1 |
| de Souza Goldim, MP | 2 |
| Danielski, LG | 2 |
| Mathias, K | 2 |
| Dacoregio, C | 1 |
| Cardoso, T | 1 |
| Predroso, GS | 1 |
| Venturini, LM | 1 |
| Zaccaron, RP | 1 |
| Silveira, PCL | 1 |
| Pinho, RA | 1 |
| Petronilho, F | 3 |
| Shin, YK | 1 |
| Kwon, S | 1 |
| Hsieh, YS | 1 |
| Han, AY | 1 |
| Seol, GH | 1 |
| Еlmahdy, MK | 1 |
| Abdelaziz, RR | 1 |
| Elmahdi, HS | 1 |
| Suddek, GM | 1 |
| Boroujeni, SS | 1 |
| Solaimanian, S | 1 |
| Jafari, RM | 1 |
| Sabzevari, O | 1 |
| Shafaroodi, H | 2 |
| Maleki, A | 1 |
| Mohammadi, P | 1 |
| Karimi, E | 1 |
| Dehpour, AR | 13 |
| Wang, L | 5 |
| Choi, HS | 1 |
| Su, Y | 1 |
| Lee, B | 2 |
| Choi, JH | 1 |
| Jang, SH | 1 |
| Jang, YS | 1 |
| Seo, JW | 1 |
| Tiwari, S | 1 |
| Gupta, P | 1 |
| Singh, A | 1 |
| Chaturvedi, S | 1 |
| Wahajuddin, M | 1 |
| Mishra, A | 2 |
| Singh, S | 3 |
| Arora, P | 1 |
| Nainwal, LM | 1 |
| Gupta, G | 1 |
| Singh, SK | 1 |
| Chellappan, DK | 1 |
| Oliver, BG | 1 |
| Dua, K | 1 |
| Farzan, M | 2 |
| Amini-Khoei, H | 4 |
| Shahrani, M | 1 |
| Bijad, E | 2 |
| Anjomshoa, M | 1 |
| Shabani, S | 1 |
| Noguchi, K | 1 |
| Sugaya, K | 1 |
| Nishijima, S | 1 |
| Sakanashi, M | 1 |
| Kadekawa, K | 1 |
| Ashitomi, K | 1 |
| Okitsu, S | 1 |
| Yamamoto, H | 2 |
| Nilsson, KF | 1 |
| Gozdzik, W | 1 |
| Zielinski, S | 1 |
| Ratajczak, K | 1 |
| Göranson, SP | 1 |
| Rodziewicz, S | 1 |
| Harbut, P | 1 |
| Barteczko-Grajek, B | 1 |
| Albert, J | 1 |
| Frostell, C | 1 |
| Malikova, E | 1 |
| Carlström, M | 3 |
| Kmecova, Z | 1 |
| Marusakova, M | 1 |
| Zsigmondova, B | 1 |
| Krenek, P | 1 |
| Klimas, J | 1 |
| Henrohn, D | 1 |
| Datta, I | 1 |
| Mekha, SR | 1 |
| Kaushal, A | 1 |
| Ganapathy, K | 1 |
| Razdan, R | 1 |
| Awazu, M | 1 |
| Abe, T | 1 |
| Hashiguchi, A | 1 |
| Hida, M | 1 |
| Gheibi, S | 1 |
| Jeddi, S | 2 |
| Kashfi, K | 1 |
| Ghasemi, A | 2 |
| Cho, DH | 1 |
| Almeida, LEF | 1 |
| Kamimura, S | 1 |
| de Souza Batista, CM | 1 |
| Spornick, N | 1 |
| Nettleton, MY | 1 |
| Walek, E | 1 |
| Smith, ML | 1 |
| Finkel, JC | 1 |
| Darbari, DS | 1 |
| Wakim, P | 1 |
| Quezado, ZMN | 1 |
| Walia, V | 1 |
| Garg, C | 1 |
| Garg, M | 1 |
| Küpeli Akkol, E | 1 |
| Gürağaç Dereli, FT | 1 |
| Taştan, H | 1 |
| Sobarzo-Sánchez, E | 1 |
| Khan, H | 1 |
| Kosutova, P | 2 |
| Mikolka, P | 2 |
| Balentova, S | 2 |
| Adamkov, M | 2 |
| Mokra, D | 2 |
| Shekarian, M | 1 |
| Komaki, A | 1 |
| Shahidi, S | 1 |
| Sarihi, A | 1 |
| Salehi, I | 1 |
| Raoufi, S | 1 |
| Gomes, JAS | 1 |
| Silva, JF | 1 |
| Marçal, AP | 1 |
| Silva, GC | 1 |
| Gomes, GF | 1 |
| de Oliveira, ACP | 1 |
| Soares, VL | 1 |
| Oliveira, MC | 1 |
| Ferreira, AVM | 1 |
| Aguiar, DC | 1 |
| McDaniel, CT | 1 |
| Panmanee, W | 2 |
| Winsor, GL | 1 |
| Gill, E | 1 |
| Bertelli, C | 1 |
| Schurr, MJ | 1 |
| Dongare, P | 1 |
| Paul, AT | 1 |
| Ko, SB | 1 |
| Lau, GW | 1 |
| Dasgupta, N | 1 |
| Bogue, AL | 1 |
| Miller, WE | 1 |
| Mortensen, JE | 1 |
| Haslam, DB | 1 |
| Dexheimer, P | 1 |
| Muruve, DA | 1 |
| Aronow, BJ | 1 |
| Forbes, MDE | 1 |
| Danilczuk, M | 1 |
| Brinkman, FSL | 1 |
| Hancock, REW | 1 |
| Meyer, TJ | 1 |
| Hassett, DJ | 2 |
| Koka, S | 1 |
| Xi, L | 1 |
| Kukreja, RC | 1 |
| Del Campo, L | 1 |
| Sánchez-López, A | 1 |
| González-Gómez, C | 1 |
| Andrés-Manzano, MJ | 1 |
| Dorado, B | 1 |
| Andrés, V | 1 |
| Sanches-Lopes, JM | 1 |
| Ferreira, GC | 4 |
| Pinheiro, LC | 8 |
| Kemp, R | 1 |
| Tanus-Santos, JE | 15 |
| Halim, AA | 1 |
| Alsayed, B | 1 |
| Embarak, S | 1 |
| Yaseen, T | 1 |
| Dabbous, S | 1 |
| Fontaine, O | 1 |
| Dueluzeau, R | 1 |
| Raibaud, P | 1 |
| Chabanet, C | 1 |
| Popoff, MR | 1 |
| Badoual, J | 1 |
| Gabilan, JC | 1 |
| Andremont, A | 1 |
| Gómez, L | 1 |
| Andrés, S | 1 |
| Sánchez, J | 1 |
| Alonso, JM | 1 |
| Rey, J | 1 |
| López, F | 1 |
| Jiménez, A | 1 |
| Yan, Z | 1 |
| Zhou, L | 1 |
| Zhao, Y | 3 |
| Wang, J | 8 |
| Huang, L | 3 |
| Hu, K | 1 |
| Liu, H | 4 |
| Guo, Z | 1 |
| Huang, H | 5 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 1 |
| Zhou, X | 1 |
| Wang, B | 4 |
| Zhang, Q | 4 |
| Yao, Y | 3 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
| Nakano, R | 2 |
| Kubota, Y | 2 |
| Hara, M | 1 |
| Sunada, K | 1 |
| Hashimoto, K | 1 |
| Kajioka, J | 1 |
| Fujishima, A | 1 |
| Jiao, J | 3 |
| Gai, QY | 3 |
| Zang, YP | 2 |
| Niu, LL | 2 |
| Fu, YJ | 3 |
| Yao, LP | 1 |
| Qin, QP | 1 |
| Wang, ZY | 1 |
| Liu, J | 4 |
| Aleksic Sabo, V | 1 |
| Knezevic, P | 1 |
| Borges-Argáez, R | 1 |
| Chan-Balan, R | 1 |
| Cetina-Montejo, L | 1 |
| Ayora-Talavera, G | 1 |
| Sansores-Peraza, P | 1 |
| Gómez-Carballo, J | 1 |
| Cáceres-Farfán, M | 1 |
| Jang, J | 1 |
| Akin, D | 1 |
| Bashir, R | 1 |
| Yu, Z | 1 |
| Zhu, J | 2 |
| Jiang, H | 4 |
| He, C | 2 |
| Xiao, Z | 1 |
| Sun, Q | 2 |
| Han, D | 1 |
| Zhao, K | 2 |
| Zhu, L | 1 |
| Li, X | 4 |
| Fu, H | 2 |
| Wilson, BK | 1 |
| Step, DL | 1 |
| Maxwell, CL | 1 |
| Gifford, CA | 1 |
| Richards, CJ | 1 |
| Krehbiel, CR | 1 |
| Warner, JM | 1 |
| Doerr, AJ | 1 |
| Erickson, GE | 1 |
| Guretzky, JA | 1 |
| Rasby, RJ | 1 |
| Watson, AK | 1 |
| Klopfenstein, TJ | 1 |
| Sun, Y | 5 |
| Liu, Z | 3 |
| Pham, TD | 1 |
| Lee, BK | 1 |
| Yang, FC | 1 |
| Wu, KH | 1 |
| Lin, WP | 1 |
| Hu, MK | 1 |
| Lin, L | 3 |
| Shao, J | 1 |
| Sun, M | 1 |
| Xu, G | 1 |
| Xu, N | 1 |
| Wang, R | 2 |
| Liu, S | 1 |
| He, H | 1 |
| Dong, X | 2 |
| Yang, M | 2 |
| Yang, Q | 1 |
| Duan, S | 1 |
| Yu, Y | 2 |
| Han, J | 2 |
| Chen, L | 3 |
| Yang, X | 2 |
| Li, W | 3 |
| Wang, T | 2 |
| Campbell, DA | 1 |
| Gao, K | 1 |
| Zager, RA | 1 |
| Johnson, ACM | 1 |
| Guillem, A | 1 |
| Keyser, J | 1 |
| Singh, B | 1 |
| Steubl, D | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Polyphenolic Extract of Vachellia Farnesiana on Glycemic Response and Safety in Healthy Volunteers.[NCT05802472] | 0 participants (Actual) | Interventional | 2022-04-06 | Withdrawn (stopped due to Because the closing date of the study is approaching) | |||
| A Randomised, Double-blind, Placebo-controlled Study Investigating the Effects of Dietary Nitrate on Vascular Function, Platelet Reactivity and Restenosis in Stable Angina[NCT02529189] | Phase 2 | 300 participants (Anticipated) | Interventional | 2015-11-30 | Active, not recruiting | ||
| The Effect of Remote Ischemic Preconditioning on the Postoperative Liver Function in Living Donor Hepatectomy: a Randomized Clinical Trial[NCT03386435] | 160 participants (Actual) | Interventional | 2016-08-22 | Completed | |||
| Alpha-lipoic Acid Adjunctive Therapy in Schizophrenia: A Randomized, Double-blind, Placebo-controlled Trial[NCT03788759] | Phase 2/Phase 3 | 48 participants (Actual) | Interventional | 2019-09-01 | Completed | ||
| Clinical and Biological Effects of Citrus-phytochemicals in Subjective Cognitive Decline: a Pilot Randomized Controlled Trial.[NCT04744922] | 80 participants (Actual) | Interventional | 2021-04-07 | Completed | |||
| Dietary Nitrate on Salivary Flow for Nasopharyngeal Carcinoma Patients Pre and Post Concurrent Chemo-radiation Therapy[NCT02854410] | 30 participants (Anticipated) | Interventional | 2016-08-31 | Not yet recruiting | |||
| Role of Saffron and Chamomile and Their Active Compounds in the Management of Parkinson Disease in the Context of Psychometric and Biochemical Measures[NCT05696665] | 120 participants (Anticipated) | Interventional | 2022-07-05 | Recruiting | |||
| A Safety and Efficacy Evaluation of Sodium Nitrite Injection for the Prevention of Ischemia-Reperfusion Injury Associated With Acute Myocardial Infarction.[NCT00924118] | Phase 2 | 30 participants (Actual) | Interventional | 2009-07-31 | Completed | ||
| Phase 1 Study of the Safety and Pharmacokinetics of Perioperative IV L-carnitine Administration in Patients With Congenital Heart Disease With Increased Pulmonary Blood Flow[NCT01825369] | Phase 1 | 0 participants (Actual) | Interventional | 2014-12-31 | Withdrawn (stopped due to Changes to cardiac surgery program) | ||
| Production of Fortified Biscuit With Chickpea and Crushed Peanut and Evaluating Its Effectiveness in Terms of Its Acceptability and Cognitive Performance: a Pilot Study Among Egyptian Primary School-aged Children[NCT05281146] | 80 participants (Actual) | Interventional | 2018-11-26 | Completed | |||
| Adiposity and Airway Inflammation in HIV-Associated Airway Disease[NCT02975258] | 102 participants (Actual) | Observational | 2015-09-30 | Completed | |||
| Safety and Effects of PDRN(Polydeoxyribonucleotide) Injection in Patient With Elbow Epicondylitis in Randomized Double-blind Active-control Comparative Study[NCT02492945] | Phase 4 | 40 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| Effect of Nitric Oxide (NO) Supplementation on Neurocognitive Measures in Argininosuccinate Lyase Deficiency (ASLD)[NCT03064048] | 16 participants (Actual) | Interventional | 2017-09-15 | Completed | |||
| A Multicenter, Randomized, Open-label, Controlled Trial to Assess Effectiveness and Safety of Rhea Health Tone® as add-on Therapy for COVID-19 in Hospitalized Adults in Indonesia[NCT04627519] | 85 participants (Actual) | Interventional | 2020-12-09 | Active, not recruiting | |||
| A Phase 2, Multi-Center, Open-label, Randomized, Parallel-Dose Study to Determine the Safety and Efficacy of AIR001 in Subjects With WHO Group 1 Pulmonary Arterial Hypertension (PAH)[NCT01725256] | Phase 2 | 29 participants (Actual) | Interventional | 2012-11-30 | Terminated (stopped due to Terminated early dt to acquisition of Sponsor and change in corporate priorities) | ||
| A Phase 2a Study of the Safety and Effectiveness of NXN-188 for the Acute Treatment of Migraine Attacks With Aura[NCT00877838] | Phase 2 | 40 participants (Anticipated) | Interventional | 2009-05-31 | Recruiting | ||
| NITRATE-OCT-CIN Trial: A Randomised, Double-blind, Placebo-controlled Study Investigating the Effects of Dietary Nitrate on Vascular Function, Platelet Reactivity and Restenosis in Stable Angina (Sub-study of the NITRATE-OCT Trial)[NCT05544981] | 300 participants (Actual) | Interventional | 2016-01-02 | Completed | |||
| Methods to Identify and Treat Severe Asthma Patients Project 1: GSNOR Phenotyping and GSNO Challenge[NCT03926741] | Early Phase 1 | 60 participants (Anticipated) | Interventional | 2019-04-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The incidence of delayed recovery of hepatic function (DRHF) were used as surrogate parameters indicating the possible benefits of RIPC. DRHF was defined based on a proposal by the International Study Group of Liver Surgery, as follows: an impaired ability of the liver to maintain its synthetic, excretory, and detoxifying functions, which are characterized by an increased PT INR and concomitant hyperbilirubinemia (considering the normal limits of the local laboratory) on or after postoperative day 5. The normal upper limits of PT and bilirubin in our institutional laboratory were 1.30 INR and 1.2 mg/dL, respectively. If either the PT INR or serum bilirubin concentration was preoperatively elevated, DRHF was defined by an increasing PT INR and increasing serum bilirubin concentration on or after postoperative day 5 (compared with the values of the previous day). (NCT03386435)
Timeframe: postoperative 7 days
| Intervention | Participants (Count of Participants) |
|---|---|
| RIPC | 5 |
| Control | 0 |
The serial assessments of routine laboratory values were used as early markers for postoperative liver function. The maximal aspartate aminotransferase level within 7 postoperative days were assessed following RIPC in living donor hepatectomy. (NCT03386435)
Timeframe: within 7 days after operation
| Intervention | IU/L (Mean) |
|---|---|
| RIPC | 145 |
| Control | 152 |
The postoperative liver regeneration index (LRI) at postoperative 1 month ) was used as surrogate parameters indicating the possible benefits of RIPC. The LRI was defined as [(VLR - VFLR)/VFLR)] × 100, where VLR is the volume of the liver remnant and VFLR is the volume of the future liver remnant. Liver volume was calculated by CT volumetry using 3-mm-thick dynamic CT images. The graft weight was subtracted from the total liver volume to define the future liver remnant. (NCT03386435)
Timeframe: 1 month
| Intervention | percentage of liver volume (Mean) |
|---|---|
| RIPC | 83.3 |
| Control | 94.9 |
The serial assessments of routine laboratory values were used as early markers for postoperative liver function. The maximal alanine aminotransferase level within 7 postoperative days were assessed following RIPC in living donor hepatectomy (NCT03386435)
Timeframe: within 7 days after operation
| Intervention | IU/L (Mean) |
|---|---|
| RIPC | 148 |
| Control | 152 |
Left ventricular infarct size by Magnetic Resonance Imaging (MRI). Calculated percentage of the left ventricular mass by MRI that has undergone infarction. (NCT00924118)
Timeframe: 4-5 days following enrollment
| Intervention | infarct percentage of left ventricle (Mean) |
|---|---|
| Sodium Nitrite | 15.5 |
| Open Control | 24 |
8 reviews available for nitrites and Disease Models, Animal
| Article | Year |
|---|---|
Topics: Adult; Alcohol Drinking; Ammonia; Animals; Anti-Inflammatory Agents; Area Under Curve; B-Lymphocytes | 2021 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
[INVOLVEMENT OF NITRIC OXIDE CYNTHASE IN THE EARLY PHASE OF THE HEART ISCHEMIC PRECONDITIONING].
Topics: Animals; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Isc | 2016 |
Nitrate and nitrite in the diet: how to assess their benefit and risk for human health.
Topics: Animals; Biomarkers; Diet; Disease Models, Animal; Humans; Meat Products; Neoplasms; Nitrates; Nitri | 2015 |
NO-Rich Diet for Lifestyle-Related Diseases.
Topics: Animals; Biological Availability; Chronic Disease; Diet; Disease Models, Animal; Fruit; Humans; Life | 2015 |
Inorganic nitrite and nitrate: evidence to support consideration as dietary nutrients.
Topics: Animals; Cardiovascular Diseases; Cardiovascular System; Consumer Product Safety; Diet; Disease Mode | 2015 |
Therapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases.
Topics: Animals; Biological Availability; Blood Pressure; Cardiovascular Diseases; Cardiovascular System; Di | 2016 |
Inflammatory agents involved in septic miscarriage.
Topics: Abortion, Septic; Abortion, Spontaneous; Animals; Cannabinoid Receptor Modulators; Disease Models, A | 2010 |
5 trials available for nitrites and Disease Models, Animal
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Pharmacologic Targeting of Red Blood Cells to Improve Tissue Oxygenation.
Topics: Adolescent; Adult; Animals; Biomarkers; Disease Models, Animal; Erythrocytes; Female; Hemoglobins; H | 2018 |
Naringin protects memory impairment and mitochondrial oxidative damage against aluminum-induced neurotoxicity in rats.
Topics: Acetylcholinesterase; Aluminum Chloride; Aluminum Compounds; Analysis of Variance; Animals; Brain; C | 2013 |
Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential.
Topics: Allopurinol; Animals; Blood Pressure; Cross-Over Studies; Disease Models, Animal; Dose-Response Rela | 2013 |
Effects of doxycycline on depressive-like behavior in mice after lipopolysaccharide (LPS) administration.
Topics: Animals; Antidepressive Agents; Brain; Brain-Derived Neurotrophic Factor; Depression; Disease Models | 2013 |
613 other studies available for nitrites and Disease Models, Animal
| Article | Year |
|---|---|
Anti-Inflammatory Effect of 4,5-Dicaffeoylquinic Acid on RAW264.7 Cells and a Rat Model of Inflammation.
Topics: Animals; Anti-Inflammatory Agents; Cell Survival; Cyclooxygenase 2; Cytokines; Dinoprostone; Disease | 2021 |
Combined antihypertensive effect of unripe Rubus coreanus Miq. and Dendropanax morbiferus H. Lév. Extracts in 1 kidney-1 clip hypertensive rats and spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Drug Therapy, Combination; | 2021 |
Gut microbiota mediated the toxicity of high concentration of dietary nitrite in C57BL/6 mice.
Topics: Animals; Disease Models, Animal; Fecal Microbiota Transplantation; Gastrointestinal Microbiome; Male | 2022 |
Ferulic Acid Attenuates Kainate-induced Neurodegeneration in a Rat Poststatus Epilepticus Model.
Topics: Animals; Coumaric Acids; Disease Models, Animal; Epilepsy, Temporal Lobe; Hippocampus; Humans; Kaini | 2023 |
Beneficial Effects of Dietary Nitrite on a Model of Nonalcoholic Steatohepatitis Induced by High-Fat/High-Cholesterol Diets in SHRSP5/Dmcr Rats: A Preliminary Study.
Topics: Animals; Captopril; Cholesterol; Diet, High-Fat; Disease Models, Animal; Liver; Liver Cirrhosis; Nit | 2022 |
Lung-Brain Crosstalk in Sepsis: Protective Effect of Prophylactic Physical Exercise Against Inflammation and Oxidative Stress in Rats.
Topics: Animals; Antioxidants; Brain; Disease Models, Animal; Inflammation; Interleukin-6; Lung; Male; Nitri | 2022 |
Linalyl acetate restores colon contractility and blood pressure in repeatedly stressed-ulcerative colitis rats.
Topics: Acetylcholine; Animals; Blood Pressure; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal | 2022 |
Effect of Agmatine on a mouse model of allergic airway inflammation: A comparative study.
Topics: Agmatine; Animals; Anti-Asthmatic Agents; Beclomethasone; Cytokines; Disease Models, Animal; Inflamm | 2022 |
Opioidergic and nitrergic systems mediate the anticonvulsant effect of mefloquine and chloroquine on seizures induced by pentylenetetrazol and maximal electroshock in mice.
Topics: Animals; Anticonvulsants; Chloroquine; Disease Models, Animal; Electroshock; Mefloquine; Mice; Naltr | 2022 |
Protective effect of 17S‑epoxy‑docosapentaenoic acid against dextran sulfate sodium induced ulcerative colitis in BALB/c mice.
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Fatty Acids, | 2022 |
4-Phenylbutyrate Mitigates the Motor Impairment and Dopaminergic Neuronal Death During Parkinson's Disease Pathology via Targeting VDAC1 Mediated Mitochondrial Function and Astrocytes Activation.
Topics: alpha-Synuclein; Animals; Astrocytes; bcl-2-Associated X Protein; Calcium; Caspase 3; Cytochromes; D | 2022 |
Orally administered solasodine, a steroidal glycoalkaloid, suppresses ovalbumin-induced exaggerated Th2-immune response in rat model of bronchial asthma.
Topics: Allergens; Aluminum Hydroxide; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Dexamethaso | 2022 |
Protective effects of vanillic acid on autistic-like behaviors in a rat model of maternal separation stress: Behavioral, electrophysiological, molecular and histopathological alterations.
Topics: Animals; Antioxidants; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Maternal | 2023 |
Evaluation of a rat model of functional urinary bladder outlet obstruction produced by chronic inhibition of nitric oxide synthase.
Topics: Animals; Disease Models, Animal; Female; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synth | 2019 |
Pulmonary Vasodilation by Intravenous Infusion of Organic Mononitrites Of 1,2-Propanediol in Acute Pulmonary Hypertension Induced by Aortic Cross Clamping and Reperfusion: A Comparison With Nitroglycerin in Anesthetized Pigs.
Topics: Animals; Disease Models, Animal; Female; Hypertension, Pulmonary; Infusions, Intravenous; Male; Nitr | 2020 |
Effects of inorganic nitrate in a rat model of monocrotaline-induced pulmonary arterial hypertension.
Topics: Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Lung; Male; Monocro | 2020 |
Influence of intranasal exposure of MPTP in multiple doses on liver functions and transition from non-motor to motor symptoms in a rat PD model.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Administration, Intranasal; Alanine Transaminase; Anim | 2020 |
Maternal undernutrition aggravates renal tubular necrosis and interstitial fibrosis after unilateral ureteral obstruction in male rat offspring.
Topics: Animals; Disease Models, Animal; Female; Fibrosis; Kidney; Kidney Tubular Necrosis, Acute; Male; Mal | 2019 |
Hydrogen sulfide potentiates the favorable metabolic effects of inorganic nitrite in type 2 diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, | 2019 |
Telmisartan Inhibits Nitric Oxide Production and Vessel Relaxation via Protein Phosphatase 2A-mediated Endothelial NO Synthase-Ser
Topics: Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Aorta; Cat | 2019 |
Sickle cell disease subjects and mouse models have elevated nitrite and cGMP levels in blood compartments.
Topics: Adult; Anemia, Sickle Cell; Animals; Biological Availability; Cyclic GMP; Disease Models, Animal; Hu | 2020 |
Amantadine exerts anxiolytic like effect in mice: Evidences for the involvement of nitrergic and GABAergic signaling pathways.
Topics: Amantadine; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Diazepam; Disease Models | 2020 |
Effect of Sorbus domestica and its active constituents in an experimental model of colitis rats induced by acetic acid.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Antioxidants; Catalase; Colitis, Ulcerative; Colon; | 2020 |
Effects of nitric oxide donor on the lung functions in a saline lavage-induced model of ARDS.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Lung; Male; Nitrates; Nitric | 2019 |
The protective and therapeutic effects of vinpocetine, a PDE1 inhibitor, on oxidative stress and learning and memory impairment induced by an intracerebroventricular (ICV) injection of amyloid beta (aβ) peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cyclic Nucleotide Phosphodiesterases, Type 1; Dis | 2020 |
High-refined carbohydrate diet consumption induces neuroinflammation and anxiety-like behavior in mice.
Topics: Adipose Tissue; Animals; Anxiety; Behavior, Animal; Dietary Carbohydrates; Disease Models, Animal; G | 2020 |
AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Biofilms; Disease Models, Animal; Down-Regulation; Drug Re | 2020 |
Chronic inhibition of phosphodiesterase 5 with tadalafil affords cardioprotection in a mouse model of metabolic syndrome: role of nitric oxide.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Dyslipidemias; Heart; Insulin Resistance; Male; | 2020 |
Vascular Smooth Muscle Cell-Specific Progerin Expression Provokes Contractile Impairment in a Mouse Model of Hutchinson-Gilford Progeria Syndrome that Is Ameliorated by Nitrite Treatment.
Topics: Adolescent; Animals; Disease Models, Animal; Humans; Lamin Type A; Mice; Muscle, Smooth, Vascular; N | 2020 |
Consistent gastric pH-dependent effects of suppressors of gastric acid secretion on the antihypertensive responses to oral nitrite.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Gast | 2020 |
Antihypertensive effect of Phragmanthera incana (Schum) Balle on NG-nitro-L-Arginine methyl ester (L-NAME) induced hypertensive rats.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Arterial Pressure; Biomark | 2020 |
Eugenol and its association with levodopa in 6-hydroxydopamine-induced hemiparkinsonian rats: Behavioural and neurochemical alterations.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Disease Models, Animal; Eugenol; Glutathione; Levodop | 2020 |
Synergistic Effects of Moderate Therapeutic Hypothermia and Levosimendan on Cardiac Function and Survival After Asphyxia-Induced Cardiac Arrest in Rats.
Topics: Animals; Asphyxia; Biomarkers; Cardiac Output; Cardiotonic Agents; Combined Modality Therapy; Diseas | 2020 |
Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anxiety; Behavior, Animal; Brain; Disease Models, Animal; D | 2020 |
Pre-exposure to mechanical ventilation and endotoxemia increases Pseudomonas aeruginosa growth in lung tissue during experimental porcine pneumonia.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Endotoxemia; Female; Infla | 2020 |
Synergic effect of eugenol oleate with amphotericin B augments anti-leishmanial immune response in experimental visceral leishmaniasis in vitro and in vivo.
Topics: Amphotericin B; Animals; Cells, Cultured; Cytokines; Disease Models, Animal; Drug Synergism; Drug Th | 2021 |
Protective effects of growth hormone-releasing hormone analogs in DSS-induced colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Biopsy; Colitis; Cytokines; Dextran Sulfate; Dinopros | 2021 |
Limonene through Attenuation of Neuroinflammation and Nitrite Level Exerts Antidepressant-Like Effect on Mouse Model of Maternal Separation Stress.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Limonene; Mate | 2021 |
Sex-Dependent Effects of Nephron Ift88 Disruption on BP, Renal Function, and Cystogenesis.
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Male; Mice; Mice, Knockout; Natriuresis; Ne | 2021 |
The Roles of Dominance of the Nitric Oxide Fractions Nitrate and Nitrite in the Epilepsy-Prone EL Mouse Brain.
Topics: Animals; Disease Models, Animal; Epilepsy; Hippocampus; Mice, Inbred Strains; Nerve Net; Nitrates; N | 2021 |
Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxide.
Topics: Animals; Cardiomegaly; Case-Control Studies; Clinical Studies as Topic; Disease Models, Animal; Fibr | 2022 |
AB569, a Novel, Topical Bactericidal Gel Formulation, Kills Pseudomonas aeruginosa and Promotes Wound Healing in a Murine Model of Burn Wound Infection.
Topics: Animals; Anti-Bacterial Agents; Body Weight; Burns; Collagen; Disease Models, Animal; Edetic Acid; G | 2021 |
Hypoxia induced cognitive impairment modulating activity of Cyperus rotundus.
Topics: Acetylcholinesterase; Animals; Cognition Disorders; Cyperus; Disease Models, Animal; Dose-Response R | 2017 |
Acetylsalicylic acid-tris-hydroxymethyl-aminomethane reduces colon mucosal damage without causing gastric side effects in a rat model of colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colitis; Colon; Disease Models, Animal; I | 2018 |
Potential therapeutic action of nitrite in sickle cell disease.
Topics: Anemia, Sickle Cell; Animals; Blood Platelets; Calcium; Disease Models, Animal; Human Umbilical Vein | 2017 |
Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone.
Topics: Animals; Antidepressive Agents, Tricyclic; Antioxidants; Brain; Brain-Derived Neurotrophic Factor; C | 2017 |
Identification and quantification of protein
Topics: Affinity Labels; Animals; Cardiotonic Agents; Cell Membrane Permeability; Cysteine; Disease Models, | 2017 |
Effects of supplementation with spray-dried porcine plasma on blood variables on piglets feed with diet contaminated by mycotoxins.
Topics: Aflatoxins; Animals; Blood Chemical Analysis; Body Weight; C-Reactive Protein; Dietary Supplements; | 2017 |
Nitroxyl Anion Mediates Relaxation in Mesenteric Arteries from Angiotensin II Hypertensive Mice.
Topics: 4-Aminopyridine; Acetylcholine; Angiotensin II; Animals; Disease Models, Animal; Hypertension; Male; | 2017 |
Chronic Remote Ischemic Conditioning Is Cerebroprotective and Induces Vascular Remodeling in a VCID Model.
Topics: Actins; Angiography; Animals; Cerebrovascular Circulation; Cognitive Dysfunction; Cytokines; Dementi | 2018 |
Mitochondrial Complex I Reversible S-Nitrosation Improves Bioenergetics and Is Protective in Parkinson's Disease.
Topics: Animals; Antioxidants; Behavior, Animal; Cell Respiration; Cell Survival; Cytoprotection; Disease Mo | 2018 |
Heat-Processed Scutellariae Radix Protects Hepatic Inflammation through the Amelioration of Oxidative Stress in Lipopolysaccharide-Induced Mice.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Che | 2017 |
Chronic treatment with Tempol during acquisition or withdrawal from CPP abolishes the expression of cocaine reward and diminishes oxidative damage.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Cyclic N-Oxides; Disease M | 2017 |
Metformin influences on respiratory system in obese mice induced by postnatal overnutrition.
Topics: Animals; Bronchoalveolar Lavage Fluid; Diet; Disease Models, Animal; Hypoglycemic Agents; Lung; Male | 2018 |
Piperine in combination with quercetin halt 6-OHDA induced neurodegeneration in experimental rats: Biochemical and neurochemical evidences.
Topics: Alkaloids; Animals; Benzodioxoles; Brain Chemistry; Disease Models, Animal; Dose-Response Relationsh | 2018 |
Nitrite administration improves sepsis-induced myocardial and mitochondrial dysfunction by modulating stress signal responses.
Topics: Animals; Disease Models, Animal; Heart; Male; Mitochondria; Myocardium; NF-kappa B; Nitrites; Rats; | 2017 |
N-acetylcysteine effects on a murine model of chronic critical limb ischemia.
Topics: Acetylcysteine; Animals; Disease Models, Animal; Hindlimb; Hypoxia; Hypoxia-Inducible Factor 1, alph | 2018 |
Protection by nitrite against the ischemic effects induced by acute myocardial infarction in mice.
Topics: Administration, Oral; Animals; Cardiotonic Agents; Disease Models, Animal; Male; Mice; Mice, Inbred | 2017 |
Chronic Mild Hyperhomocysteinemia Alters Inflammatory and Oxidative/Nitrative Status and Causes Protein/DNA Damage, as well as Ultrastructural Changes in Cerebral Cortex: Is Acetylsalicylic Acid Neuroprotective?
Topics: Acetylcholinesterase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Catalase; Cerebral | 2018 |
Involvement of NO/NMDA-R pathway in the behavioral despair induced by amphetamine withdrawal.
Topics: Amphetamine; Analysis of Variance; Animals; Central Nervous System Stimulants; Depression; Disease M | 2018 |
Venlafaxine prevents morphine antinociceptive tolerance: The role of neuroinflammation and the l-arginine-nitric oxide pathway.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents, Second-Generation; Brain; Cytokines; Disease Mod | 2018 |
Aspidosperma pyrifolium Mart: neuroprotective, antioxidant and anti-inflammatory effects in a Parkinson's disease model in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aspidosperma; Behavior, Animal; Corpus Striatum; Di | 2018 |
Maternal administration of cannabidiol promotes an anti-inflammatory effect on the intestinal wall in a gastroschisis rat model.
Topics: Animals; Anti-Inflammatory Agents; Cannabidiol; Disease Models, Animal; Enteritis; Female; Fetal Dis | 2018 |
Chronic Intermittent Hypobaric Hypoxia (4600 M) Attenuates Pulmonary Vasodilation Induced by Acetylcholine or Sodium Nitroprusside.
Topics: Acetylcholine; Altitude; Altitude Sickness; Animals; Blood Pressure; Body Weight; Chronic Disease; D | 2018 |
Inhibition of Fatty Acid Amide Hydrolase by PF-3845 Alleviates the Nitrergic and Proinflammatory Response in Rat Hippocampus Following Acute Stress.
Topics: Amidohydrolases; Animals; Corticosterone; Cytokines; Disease Models, Animal; Endocannabinoids; Enzym | 2018 |
The GTN patch: a simple and effective new approach to cardioprotection?
Topics: Administration, Cutaneous; Animals; Blood Pressure; Disease Models, Animal; Male; Mice, Inbred C57BL | 2018 |
Dimethyl Fumarate Limits Neuroinflammation and Oxidative Stress and Improves Cognitive Impairment After Polymicrobial Sepsis.
Topics: Animals; Catalase; Cognition Disorders; Cytokines; Dimethyl Fumarate; Disease Models, Animal; Explor | 2018 |
Functionalized spirooxindole-indolizine hybrids: Stereoselective green synthesis and evaluation of anti-inflammatory effect involving TNF-α and nitrite inhibition.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Crystallography, X-Ray; Disease Model | 2018 |
Inactivation of bpsl1039-1040 ATP-binding cassette transporter reduces intracellular survival in macrophages, biofilm formation and virulence in the murine model of Burkholderia pseudomallei infection.
Topics: Anaerobiosis; Animals; ATP-Binding Cassette Transporters; Bacterial Proteins; Biofilms; Burkholderia | 2018 |
Chondroprotective effects of aqueous extract of Anthriscus sylvestris leaves on osteoarthritis in vitro and in vivo through MAPKs and NF-κB signaling inhibition.
Topics: Animals; Apiaceae; Cartilage, Articular; Cell Survival; Cells, Cultured; Chondrocytes; Cyclooxygenas | 2018 |
Effect of long-term nitrite administration on browning of white adipose tissue in type 2 diabetic rats: A stereological study.
Topics: Adipocytes; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Body Weight; Cyclic GMP; Diabetes | 2018 |
Bone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascades.
Topics: Animals; Bone Marrow Transplantation; Calcium-Binding Proteins; Culture Media, Conditioned; Cytokine | 2018 |
Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Benzylisoquinolines; Colitis, Ulcerative; C | 2018 |
Effects of citrus leaf extract on aortic vascular reactivity in hypertensive rats fed repeatedly heated vegetable oil.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Citrus; Cooking; Disease Models, Animal; Ho | 2019 |
Comparative study of alpha- and beta-pinene effect on PTZ-induced convulsions in mice.
Topics: Animals; Anticonvulsants; Bicyclic Monoterpenes; Brain; Bridged Bicyclo Compounds; Disease Models, A | 2019 |
Phenolic Compounds in Organic and Aqueous Extracts from
Topics: Acacia; Animals; Anti-Inflammatory Agents; Antioxidants; Cell Survival; Chromatography, High Pressur | 2018 |
Anaerobic nitrate reduction divergently governs population expansion of the enteropathogen Vibrio cholerae.
Topics: Anaerobiosis; Animals; Bacteria; Cholera; Disease Models, Animal; Fermentation; Hydrogen-Ion Concent | 2018 |
Oxidative stress on ischemia/reperfusion injury in mice with non-alcoholic hepatic steatosis or steatohepatitis.
Topics: Animals; Disease Models, Animal; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Nitrites; Non-a | 2018 |
Nitrite treatment downregulates vascular MMP-2 activity and inhibits vascular remodeling in hypertension independently of its antihypertensive effects.
Topics: Animals; Antihypertensive Agents; Antioxidants; Aorta; Blood Pressure; Disease Models, Animal; Febux | 2019 |
Nitrite Protects Neurons Against Hypoxic Damage Through
Topics: Animals; Caspase 6; Catalytic Domain; Cell Line; Disease Models, Animal; Hypoxia, Brain; Mice; Mice, | 2019 |
Dietary Nitrite Attenuates Elastase-Induced Pulmonary Emphysema in a Mouse Model.
Topics: Animals; Diet; Disease Models, Animal; Female; Mice, Inbred C57BL; Nitrates; Nitric Oxide; Nitrites; | 2018 |
Lycopene mitigates pulmonary emphysema induced by cigarette smoke in a murine model.
Topics: Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Cigarette Smoking; Cytokines; Disease Models, A | 2019 |
Effects of phosphodiesterase 5 inhibitor sildenafil on the respiratory parameters, inflammation and apoptosis in a saline lavage-induced model of acute lung injury.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Apoptosis; Bronchoalveolar Lavage; Cytokines; | 2018 |
Role of Probiotic Mixture with and Without Green Tea Extract in Prevention of Hepatorenal Syndrome in Rat Model.
Topics: Animals; Antioxidants; Bifidobacterium; C-Reactive Protein; Creatinine; Disease Models, Animal; Fece | 2019 |
Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson's Disease.
Topics: alpha-Synuclein; Animals; Antioxidants; Brain; Catalase; Cyclooxygenase 2; Cytokines; Disease Models | 2019 |
Antioxidant and antihypertensive responses to oral nitrite involves activation of the Nrf2 pathway.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Catalase; Disease Models, Animal; Gl | 2019 |
Antitumor action of diphenyl diselenide nanocapsules: In vitro assessments and preclinical evidence in an animal model of glioblastoma multiforme.
Topics: Animals; Antineoplastic Agents; Astrocytes; Benzene Derivatives; Cell Proliferation; Cell Survival; | 2019 |
Heme-induced biomarkers associated with red meat promotion of colon cancer are not modulated by the intake of nitrite.
Topics: Acetylcysteine; Animals; Biomarkers; Body Weight; Colonic Neoplasms; Disease Models, Animal; Drinkin | 2013 |
Pneumonia-induced sepsis in mice: temporal study of inflammatory and cardiovascular parameters.
Topics: Animals; Bacterial Load; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Humans; Kl | 2013 |
Activation of cGMP/protein kinase G pathway in postconditioned myocardium depends on reduced oxidative stress and preserved endothelial nitric oxide synthase coupling.
Topics: Animals; Biopterins; Cell Death; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, A | 2013 |
The nitroxyl donor, Angeli's salt, inhibits inflammatory hyperalgesia in rats.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cytokin | 2013 |
Tomato lycopene attenuates myocardial infarction induced by isoproterenol: electrocardiographic, biochemical and anti-apoptotic study.
Topics: Animals; Antioxidants; Apoptosis; Cardiotonic Agents; Carotenoids; Caspase 3; Disease Models, Animal | 2012 |
Effect of 7-difluoromethyl-5, 4'-dimethoxygenistein on aorta atherosclerosis in hyperlipidemia ApoE(-/-) mice induced by a cholesterol-rich diet.
Topics: Animals; Aorta, Thoracic; Apolipoproteins E; Atherosclerosis; Diet, High-Fat; Disease Models, Animal | 2013 |
Evaluation of the Hepa Wash® treatment in pigs with acute liver failure.
Topics: Ammonia; Animals; Blood Pressure; Cardiac Output; Creatinine; Dialysis; Disease Models, Animal; Fema | 2013 |
The effect of calorie restriction on acute ethanol-induced oxidative and nitrosative liver injury in rats.
Topics: Acute Disease; Animals; Caloric Restriction; Disease Models, Animal; Ethanol; Glutathione; Liver; Li | 2013 |
Granulocyte colony stimulating factor (GCSF) improves memory and neurobehavior in an amyloid-β induced experimental model of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Base Sequence; Behavior, Animal; Disease Models, A | 2013 |
Ameliorative effect of Noni fruit extract on streptozotocin-induced memory impairment in mice.
Topics: Acetylcholine; Acetylcholinesterase; Adenosine Triphosphate; Animals; Antibiotics, Antineoplastic; A | 2013 |
Mechanism underlying anti-hyperalgesic and anti-allodynic properties of anomalin in both acute and chronic inflammatory pain models in mice through inhibition of NF-κB, MAPKs and CREB signaling cascades.
Topics: Acute Disease; Adenosine Triphosphate; Analgesics; Animals; Chronic Disease; Coumarins; Cyclic AMP R | 2013 |
Chronic exercise downregulates myocardial myoglobin and attenuates nitrite reductase capacity during ischemia-reperfusion.
Topics: Animals; Cardiotonic Agents; Carrier Proteins; Disease Models, Animal; Enzyme Activation; Gene Expre | 2013 |
Croton antisyphiliticus Mart. attenuates the inflammatory response to carrageenan-induced pleurisy in mice.
Topics: Adenosine Deaminase; Animals; Anti-Inflammatory Agents; Carrageenan; Croton; Disease Models, Animal; | 2014 |
Antiepileptogenic effect of curcumin on kainate-induced model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Behavior, Animal; Biomarkers; Curcumin; Disease Models, Animal; Epilepsy, | 2013 |
Oral administration of ginseng ameliorates cyclosporine-induced pancreatic injury in an experimental mouse model.
Topics: Administration, Oral; Animals; Apoptosis; Cyclosporine; Disease Models, Animal; Insulin-Secreting Ce | 2013 |
Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: implication of reconstituted tumor microenvironment and multidrug resistance phenotype.
Topics: Animals; Anti-Obesity Agents; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Proliferatio | 2014 |
Sex differences in protective effect of recombinant human erythropoietin against cisplatin-induced nephrotoxicity in rats.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Blood Urea Nitrogen; Body Weight; Cisplatin; Cr | 2013 |
Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model.
Topics: Animals; Berberine; Caspase 3; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Hippoc | 2013 |
Dynamics of oxidative/nitrosative stress in mice with methionine-choline-deficient diet-induced nonalcoholic fatty liver disease.
Topics: Animals; Antioxidants; C-Reactive Protein; Catalase; Choline Deficiency; Disease Models, Animal; Fer | 2014 |
Interactive effects of mechanical ventilation, inhaled nitric oxide and oxidative stress in acute lung injury.
Topics: Acute Lung Injury; Administration, Inhalation; Animals; Bronchodilator Agents; Cell Count; Disease M | 2014 |
Verapamil augments the neuroprotectant action of berberine in rat model of transient global cerebral ischemia.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Berberine; Brain; Disease Models, Animal; Glutathio | 2013 |
Minocycline modulates neuroprotective effect of hesperidin against quinolinic acid induced Huntington's disease like symptoms in rats: behavioral, biochemical, cellular and histological evidences.
Topics: Animals; Behavior, Animal; Brain; Caspase 3; Disease Models, Animal; Drug Synergism; Electron Transp | 2013 |
Systemic administration of Rosmarinus officinalis attenuates the inflammatory response induced by carrageenan in the mouse model of pleurisy.
Topics: Abietanes; Adenosine Deaminase; Animals; Anti-Inflammatory Agents; Carrageenan; Cinnamates; Cytokine | 2013 |
Alpha-lipoic acid restores tear production in an animal model of dry eye.
Topics: Animals; Antioxidants; Ascorbic Acid; Chromatography, High Pressure Liquid; Conjunctiva; Cornea; Die | 2014 |
T-bet regulates immunity to Francisella tularensis live vaccine strain infection, particularly in lungs.
Topics: Animals; Antibodies, Bacterial; Bacterial Vaccines; Cytokines; Disease Models, Animal; Francisella t | 2014 |
Preventive and therapeutic effects of nitrite supplementation in experimental inflammatory bowel disease.
Topics: Animals; Cell Line; Colitis; Colon; Dextran Sulfate; Dietary Supplements; Disease Models, Animal; Dr | 2014 |
Agmatine attenuates silica-induced pulmonary fibrosis.
Topics: Agmatine; Animals; Biomarkers; Bronchoalveolar Lavage Fluid; Cytoprotection; Disease Models, Animal; | 2014 |
Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia.
Topics: Animals; Antioxidants; Apoptosis; Aquaporin 4; Blotting, Western; Brain Edema; Brain Ischemia; Calci | 2014 |
Hyperbaric oxygen treatment in the experimental spinal cord injury model.
Topics: Animals; Disease Models, Animal; Hyperbaric Oxygenation; Male; Nitrites; Rats; Recovery of Function; | 2014 |
Tauroursodeoxycholic acid reduces glial cell activation in an animal model of acute neuroinflammation.
Topics: Animals; Animals, Newborn; Calcium-Binding Proteins; Cell Movement; Cell Proliferation; Cells, Cultu | 2014 |
Effects of naproxen on immune responses in a colchicine-induced rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Brain; Colchicine; | 2014 |
Asphyxia and therapeutic hypothermia modulate plasma nitrite concentrations and carotid vascular resistance in preterm fetal sheep.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Carotid Arteries; Cerebrovascular Circulation; Cereb | 2014 |
Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Cellulase; Diet, Mediterranean; Disease Model | 2014 |
Silymarin ameliorates memory deficits and neuropathological changes in mouse model of high-fat-diet-induced experimental dementia.
Topics: Acetylcholinesterase; Animals; Body Weight; Brain; Cholesterol; Dementia; Diet, High-Fat; Disease Mo | 2014 |
The inhibition of Rho kinase blocks cell migration and accumulation possibly by challenging inflammatory cytokines and chemokines on astrocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Astrocytes; CD4-Positive T | 2014 |
Increased aortic stiffness elevates pulse and mean pressure and compromises endothelial function in Wistar rats.
Topics: Animals; Aorta; Arterial Pressure; Cytochrome P-450 Enzyme System; Disease Models, Animal; Dose-Resp | 2014 |
Conventional, but not remote ischemic preconditioning, reduces iNOS transcription in liver ischemia/reperfusion.
Topics: Animals; Disease Models, Animal; Down-Regulation; Hindlimb; Inflammation Mediators; Ischemic Precond | 2014 |
The potential role of Morus alba leaves extract on the brain of mice infected with Schistosoma mansoni.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Antioxidants; Brain; Catalase; Chlorides; Disea | 2014 |
The effect of melatonin on procarbazine induced testicular toxicity on rats.
Topics: Animals; Antineoplastic Agents; Antioxidants; Cytoprotection; Disease Models, Animal; Follicle Stimu | 2014 |
Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Anxiety; Benzodioxoles; Diazepam; Disease Models, Animal; D | 2014 |
NADPH oxidase in the renal microvasculature is a primary target for blood pressure-lowering effects by inorganic nitrate and nitrite.
Topics: Animals; Blood Pressure; Disease Models, Animal; Hypertension; Kidney; Male; Mice; Mice, Inbred C57B | 2015 |
Effect of Ca2EDTA on zinc mediated inflammation and neuronal apoptosis in hippocampus of an in vivo mouse model of hypobaric hypoxia.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Chelating Agents; Disease Models, Animal; Edetic Aci | 2014 |
Relationship between oxidative stress and pathological findings in abomasum of infected lambs by Haemonchus contortus.
Topics: Abomasum; Advanced Oxidation Protein Products; Animals; Animals, Newborn; Antioxidants; Biomarkers; | 2014 |
Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice.
Topics: Animals; Antidepressive Agents; Biphenyl Compounds; Brain-Derived Neurotrophic Factor; Corticosteron | 2014 |
Paliperidone prevents brain toll-like receptor 4 pathway activation and neuroinflammation in rat models of acute and chronic restraint stress.
Topics: Animals; Antipsychotic Agents; Brain; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Dose-R | 2014 |
Intranasal curcumin ameliorates lipopolysaccharide-induced acute lung injury in mice.
Topics: Acute Lung Injury; Administration, Intranasal; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bro | 2015 |
Memory recuperative potential of rifampicin in aluminum chloride-induced dementia: role of pregnane X receptors.
Topics: Acetylcholinesterase; Aluminum Chloride; Aluminum Compounds; Amyloid; Animals; Brain; Chlorides; Cog | 2015 |
Anti-inflammatory effects of methanol extract of Canarium lyi C.D. Dai & Yakovlev in RAW 264.7 macrophages and a murine model of lipopolysaccharide-induced lung injury.
Topics: Anacardiaceae; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cell Line; Cell Surv | 2015 |
Protective effect of leaf essential oil from Cinnamomum osmophloeum Kanehira on endotoxin-induced intestinal injury in mice associated with suppressed local expression of molecules in the signaling pathways of TLR4 and NLRP3.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Carrier Proteins; Cinnamomum; Cytokines; Disease Mod | 2015 |
Co-occurrence of anxiety and depressive-like behaviors following adolescent social isolation in male mice; possible role of nitrergic system.
Topics: Animals; Animals, Newborn; Anxiety Disorders; Depression; Disease Models, Animal; Enzyme Inhibitors; | 2015 |
Protective and immunomodulatory effect of flos Lonicerae japonicae by augmenting IL-10 expression in a murine model of acute lung inflammation.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cell Count; Cyto | 2015 |
Effects of hemin and nitrite on intestinal tumorigenesis in the A/J Min/+ mouse model.
Topics: Animals; Diet; Disease Models, Animal; Female; Hemin; Intestinal Neoplasms; Male; Mice; Nitrites; Ri | 2015 |
Xanthine Oxidoreductase Function Contributes to Normal Wound Healing.
Topics: Aldehyde Oxidase; Animals; Arginase; Cell Proliferation; Dietary Supplements; Disease Models, Animal | 2015 |
Effect of sodium nitrite on ischaemia and reperfusion-induced arrhythmias in anaesthetized dogs: is protein S-nitrosylation involved?
Topics: Administration, Intravenous; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, | 2015 |
Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome.
Topics: Angiogenesis Inducing Agents; Animals; Delayed-Action Preparations; Disease Models, Animal; Hindlimb | 2015 |
Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzodioxoles; Brain; Calcium-Binding Pr | 2015 |
Alpha-lipoic acid alone and combined with clozapine reverses schizophrenia-like symptoms induced by ketamine in mice: Participation of antioxidant, nitrergic and neurotrophic mechanisms.
Topics: Analysis of Variance; Animals; Antioxidants; Antipsychotic Agents; Brain; Brain-Derived Neurotrophic | 2015 |
Effects of palmitoylethanolamide and silymarin combination treatment in an animal model of kidney ischemia and reperfusion.
Topics: Active Transport, Cell Nucleus; Amides; Animals; Apoptosis; Cell Nucleus; Chymases; Cytokines; Disea | 2015 |
Effect of cadmium chloride exposure during the induction of collagen induced arthritis.
Topics: Animals; Arthritis, Experimental; Cadmium Chloride; Catalase; Collagen Type II; Cyclooxygenase 2; Di | 2015 |
Rimonabant Improves Oxidative/Nitrosative Stress in Mice with Nonalcoholic Fatty Liver Disease.
Topics: Animals; Cannabinoid Receptor Antagonists; Diet, High-Fat; Disease Models, Animal; Glutathione; Live | 2015 |
Dimethylarginine dimethylaminohydrolase 1 is involved in spinal nociceptive plasticity.
Topics: Action Potentials; Amidohydrolases; Animals; Cells, Cultured; Disease Models, Animal; Ganglia, Spina | 2015 |
Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Desoxycorticosterone; Dinoprost; Dis | 2015 |
Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms.
Topics: Alzheimer Disease; Animals; Apoptosis; Avoidance Learning; Disease Models, Animal; DNA Fragmentation | 2015 |
Gastric S-nitrosothiol formation drives the antihypertensive effects of oral sodium nitrite and nitrate in a rat model of renovascular hypertension.
Topics: Animals; Antihypertensive Agents; Antioxidants; Disease Models, Animal; Free Radicals; Gastric Mucos | 2015 |
β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cells, Cultured; Cytokines; Disease Models, Animal; En | 2015 |
Gender and estrous cycle influences on behavioral and neurochemical alterations in adult rats neonatally administered ketamine.
Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Endophenotypes | 2016 |
ALCAR Exerts Neuroprotective and Pro-Neurogenic Effects by Inhibition of Glial Activation and Oxidative Stress via Activation of the Wnt/β-Catenin Signaling in Parkinsonian Rats.
Topics: Acetylcarnitine; Animals; Antioxidants; Ataxia; Axons; Behavior, Animal; Brain; Cell Nucleus; Diseas | 2016 |
Asiatic acid alleviates cardiovascular remodelling in rats with L-NAME-induced hypertension.
Topics: Animals; Antihypertensive Agents; Aorta; Biomarkers; Blood Pressure; Collagen; Disease Models, Anima | 2015 |
Abrogated cardioprotective effect of ischemic preconditioning in ovariectomized rat heart.
Topics: Animals; Caveolin 1; Creatine Kinase, MB Form; Disease Models, Animal; Female; Heart; In Vitro Techn | 2016 |
Behavioral despair associated with a mouse model of Crohn's disease: Role of nitric oxide pathway.
Topics: Animals; Antidepressive Agents; Colitis; Colon; Crohn Disease; Depression; Disease Models, Animal; E | 2016 |
S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Densitometry; Dinoprostone; Disease M | 2015 |
Chronic liver injury in mice promotes impairment of skin barrier function via tumor necrosis factor-alpha.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 2016 |
Role of xanthine oxidoreductase in the anti-thrombotic effects of nitrite in rats in vivo.
Topics: Animals; Biomarkers; Blood Coagulation; Blood Platelets; Blood Pressure; Disease Models, Animal; Fib | 2016 |
Minocycline Attenuates Depressive-Like Behaviour Induced by Rat Model of Testicular Torsion: Involvement of Nitric Oxide Pathway.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cyclic GMP; Depression; Disease Models, Animal; Ma | 2016 |
Inhaled, nebulized sodium nitrite protects in murine and porcine experimental models of hemorrhagic shock and resuscitation by limiting mitochondrial injury.
Topics: Administration, Inhalation; Animals; Blotting, Western; Disease Models, Animal; Mice; Mitochondria; | 2015 |
Calcium Channel Blockade and Peroxisome Proliferator Activated Receptor γ Agonism Diminish Cognitive Loss and Preserve Endothelial Function During Diabetes Mellitus.
Topics: Animals; Attention; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Calcium Channels; Capillar | 2016 |
Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anticonvulsants; Arginine; Chloroquine; Disease M | 2016 |
The MSHA strain of Pseudomonas aeruginosa (PA-MSHA) inhibits gastric carcinoma progression by inducing M1 macrophage polarization.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cytokines; Disease Models, | 2016 |
Angiotensin Receptor Blockade Modulates NFκB and STAT3 Signaling and Inhibits Glial Activation and Neuroinflammation Better than Angiotensin-Converting Enzyme Inhibition.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Astrocytes; Cel | 2016 |
Modulation of the antioxidant nuclear factor (erythroid 2-derived)-like 2 pathway by antidepressants in rats.
Topics: Animals; Antidepressive Agents; Antioxidants; Corticosterone; Depressive Disorder; Disease Models, A | 2016 |
Lithium attenuated the depressant and anxiogenic effect of juvenile social stress through mitigating the negative impact of interlukin-1β and nitric oxide on hypothalamic-pituitary-adrenal axis function.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety Disorders; Corticosterone; Depressive D | 2016 |
The effect of prolonged dietary nitrate supplementation on atherosclerosis development.
Topics: Animals; Atherosclerosis; Dietary Supplements; Disease Models, Animal; Mice; Mice, Knockout; Nitrite | 2016 |
Enriched Flavonoid Fraction from Cecropia pachystachya Trécul Leaves Exerts Antidepressant-like Behavior and Protects Brain Against Oxidative Stress in Rats Subjected to Chronic Mild Stress.
Topics: Animals; Antidepressive Agents; Chronic Disease; Creatine Kinase; Disease Models, Animal; Explorator | 2016 |
Inflammatory mediators in a short-time mouse model of doxorubicin-induced cardiotoxicity.
Topics: Animals; Antibiotics, Antineoplastic; Cardiotoxicity; Disease Models, Animal; Doxorubicin; Echocardi | 2016 |
An Abnormal Nitric Oxide Metabolism Contributes to Brain Oxidative Stress in the Mouse Model for the Fragile X Syndrome, a Possible Role in Intellectual Disability.
Topics: Animals; Blotting, Western; Brain; Cytosol; Disease Models, Animal; Fragile X Mental Retardation Pro | 2016 |
Hypoxia induces NO-dependent release of heparan sulfate in fibroblasts from the Alzheimer mouse Tg2576 by activation of nitrite reduction.
Topics: Alzheimer Disease; Animals; Antibodies, Monoclonal; Ascorbic Acid; Cell Hypoxia; Deferoxamine; Disea | 2016 |
Distant effects of unilateral renal ischemia/reperfusion on contralateral kidney but not lung in rats: the roles of ROS and iNOS.
Topics: Acute Kidney Injury; alpha-Tocopherol; Animals; Antioxidants; Disease Models, Animal; Enzyme Inhibit | 2016 |
Selective Serotonin-norepinephrine Re-uptake Inhibition Limits Renovas-cular-hypertension Induced Cognitive Impairment, Endothelial Dysfunction, and Oxidative Stress Injury.
Topics: Acetylcholinesterase; Animals; Arterial Pressure; Cognition Disorders; Disease Models, Animal; Dose- | 2016 |
Zebrafish as a Model to Assess the Teratogenic Potential of Nitrite.
Topics: Animals; Disease Models, Animal; Embryo, Nonmammalian; Embryonic Development; Female; Male; Models, | 2016 |
Tempol improves xanthine oxidoreductase-mediated vascular responses to nitrite in experimental renovascular hypertension.
Topics: Animals; Antioxidants; Blood Pressure; Cyclic N-Oxides; Disease Models, Animal; Humans; Hypertension | 2016 |
The E3 Ubiquitin Ligase c-Cbl Inhibits Microglia-Mediated CNS Inflammation by Regulating PI3K/Akt/NF-κB Pathway.
Topics: Animals; Brain; Cell Line, Transformed; Cytokines; Disease Models, Animal; Encephalitis; Enzyme Inhi | 2016 |
Neonatal anoxia leads to time dependent progression of mitochondrial linked apoptosis in rat cortex and associated long term sensorimotor deficits.
Topics: Analysis of Variance; Animals; Animals, Newborn; Annexins; Apoptosis; bcl-2-Associated X Protein; Ca | 2016 |
Effect of ruthenium red, a ryanodine receptor antagonist in experimental diabetes induced vascular endothelial dysfunction and associated dementia in rats.
Topics: Animals; Aorta; Blood Glucose; Body Weight; Brain; Calcium Channel Blockers; Dementia; Diabetes Mell | 2016 |
Prior voluntary wheel running attenuates neuropathic pain.
Topics: Activating Transcription Factor 3; Animals; Calcium-Binding Proteins; Constriction, Pathologic; Cyto | 2016 |
Neurokinin-1 receptor inhibition reverses ischaemic brain injury and dementia in bilateral common carotid artery occluded rats: possible mechanisms.
Topics: Acetylcholinesterase; Animals; Aprepitant; Brain; Brain Ischemia; Carotid Stenosis; Dementia, Vascul | 2016 |
Chronic Alcohol Intoxication and Cortical Ischemia: Study of Their Comorbidity and the Protective Effects of Minocycline.
Topics: Alcoholic Intoxication; Animals; Behavior, Animal; Brain Ischemia; Disease Models, Animal; Endotheli | 2016 |
Effects of caffeic acid on learning deficits in a model of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blotting, Western; Brain; Caffeic Acids; Caspase 3 | 2016 |
Alzheimer's disease like pathology induced six weeks after aggregated amyloid-beta injection in rats: increased oxidative stress and impaired long-term memory with anxiety-like behavior.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Anxiety; Body | 2016 |
Pulmonary anti-inflammatory effects and spasmolytic properties of Costa Rican noni juice (Morinda citrifolia L.).
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Calcium Channel Blockers; Cal | 2016 |
Antiinflammatory and immunomodulatory activity of an ethanolic extract from the stem bark of Terminalia catappa L. (Combretaceae): In vitro and in vivo evidences.
Topics: Animals; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Colitis; Colon; Cytokines; | 2016 |
In situ eNOS/NO up-regulation-a simple and effective therapeutic strategy for diabetic skin ulcer.
Topics: Animals; Blood Glucose; Cell Survival; Diabetes Complications; Diabetes Mellitus, Type 1; Disease Mo | 2016 |
Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular Dysfunction.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Cyclic GMP; Disease Models, Animal; Dose-Resp | 2016 |
Pelargonidin improves memory deficit in amyloid β25-35 rat model of Alzheimer's disease by inhibition of glial activation, cholinesterase, and oxidative stress.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anthocyanins; Catalase; Cholinesterases; Disease | 2016 |
Mincle Signaling Promotes Con A Hepatitis.
Topics: Animals; Concanavalin A; Disease Models, Animal; Hepatitis; Humans; Inflammation; Lectins, C-Type; L | 2016 |
Anticonvulsant effect of argan oil on pilocarpine model induced status epilepticus in wistar rats.
Topics: Animals; Anticonvulsants; Catalase; Diet; Disease Models, Animal; Hippocampus; Lipid Peroxidation; M | 2018 |
Prophylactic Chronic Zinc Administration Increases Neuroinflammation in a Hypoxia-Ischemia Model.
Topics: Animals; Chemokines; Chlorides; Disease Models, Animal; Drug Administration Schedule; Fibroblast Gro | 2016 |
Effects of crocin on brain oxidative damage and aversive memory in a 6-OHDA model of Parkinson's disease.
Topics: Animals; Antioxidants; Carotenoids; Cerebral Cortex; Disease Models, Animal; Glutathione Peroxidase; | 2016 |
Electrophilic nitro-fatty acids suppress allergic contact dermatitis in mice.
Topics: Animals; Biomarkers; Dermatitis, Allergic Contact; Disease Models, Animal; Fatty Acids; Female; Gene | 2017 |
Oral nitrite circumvents antiseptic mouthwash-induced disruption of enterosalivary circuit of nitrate and promotes nitrosation and blood pressure lowering effect.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Hypertension; Male; Mouthw | 2016 |
Impact of the Chronic Omega-3 Fatty Acids Supplementation in Hemiparkinsonism Model Induced by 6-Hydroxydopamine in Rats.
Topics: Animals; Apomorphine; Biogenic Monoamines; Brain; Dietary Supplements; Disease Models, Animal; Fatty | 2017 |
An
Topics: Animals; Bacterial Proteins; Bacterial Vaccines; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocy | 2016 |
Nilotinib, a tyrosine kinase inhibitor exhibits protection against acute pancreatitis-induced lung and liver damage in rats.
Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents; Antioxidants; Arginine; Biomarkers; Cyto | 2017 |
Reperfusion therapy with recombinant human relaxin-2 (Serelaxin) attenuates myocardial infarct size and NLRP3 inflammasome following ischemia/reperfusion injury via eNOS-dependent mechanism.
Topics: Animals; Cardiovascular Agents; Caspase 1; Cells, Cultured; Disease Models, Animal; Inflammasomes; M | 2017 |
Peripheral NMDA Receptor/NO System Blockage Inhibits Itch Responses Induced by Chloroquine in Mice.
Topics: Animals; Behavior, Animal; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; En | 2017 |
Effects of aerobic exercise training on metabolism of nitric oxide and endothelin-1 in lung parenchyma of rats with pulmonary arterial hypertension.
Topics: Animals; Disease Models, Animal; Endothelin-1; Hypertension, Pulmonary; Male; Monocrotaline; Nitric | 2017 |
A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis.
Topics: Adult; Allopurinol; Animals; Blood Pressure; Disease Models, Animal; Female; Homeostasis; Humans; Li | 2008 |
Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarction.
Topics: Animals; Anions; Apoptosis; Cardiotonic Agents; Cytoprotection; Disease Models, Animal; Dogs; Hemogl | 2008 |
Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat.
Topics: Animals; Behavior, Animal; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Curcumin; Disea | 2008 |
Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation-induced hepatic injury.
Topics: Amidines; Animals; Benzylamines; Blood Pressure; Chemokines; Cytokines; Disease Models, Animal; Enzy | 2008 |
The prevention of endothelial dysfunction through endothelial cell apoptosis inhibition in a hypercholesterolemic rabbit model: the effect of L-arginine supplementation.
Topics: Animals; Aorta; Apoptosis; Arginine; Atherosclerosis; Cell Count; Cholesterol; Dietary Supplements; | 2008 |
Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress.
Topics: Acetylcholine; Animals; Blood Pressure; Chronic Disease; Disease Models, Animal; Female; HSP90 Heat- | 2008 |
L-arginine supplementation influenced nitrite but not nitrate and total nitrite in rabbit model of hypercholesterolemia.
Topics: Animals; Arginine; Cholesterol; Dietary Supplements; Disease Models, Animal; Hypercholesterolemia; M | 2008 |
Proinflammatory stimuli are needed for induction of microglial cell-mediated AbetaPP_{244-C} and Abeta-neurotoxicity in hippocampal cultures.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Blotting, Western; Cell Death; Disease M | 2008 |
Hyperthermia amplifies brain cytokine and reactive oxygen species response in a model of perinatal inflammation.
Topics: Animals; Brain; Cytokines; Disease Models, Animal; Female; Hyperthermia, Induced; Hypoxia; Inflammat | 2008 |
Nitrite consumption in ischemic rat heart catalyzed by distinct blood-borne and tissue factors.
Topics: Allopurinol; Animals; Catalysis; Disease Models, Animal; Enzyme Inhibitors; Erythrocytes; Glucose; G | 2008 |
Targeted deletion of neuropeptide Y (NPY) modulates experimental colitis.
Topics: Animals; Catalase; Colitis; Dextran Sulfate; Disease Models, Animal; Gene Deletion; Glutathione; Inf | 2008 |
A hyperlipidemic rabbit model provides new insights into pulmonary zinc exposure effects on cardiovascular health.
Topics: Acetylglucosaminidase; Animals; Atherosclerosis; Bronchoalveolar Lavage Fluid; Cholesterol; Disease | 2008 |
Role of glial cells in the functional expression of LL-37/rat cathelin-related antimicrobial peptide in meningitis.
Topics: Adolescent; Adult; Aged; Animals; Animals, Newborn; Anti-Bacterial Agents; Antimicrobial Cationic Pe | 2008 |
Vaccination with a novel recombinant Leishmania antigen plus MPL provides partial protection against L. donovani challenge in experimental model of visceral leishmaniasis.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Protozoan; Antigens, Protozoan; Cricetinae; Cytokines; | 2009 |
Nitric oxide plays a crucial role in the development/progression of nonalcoholic steatohepatitis in the choline-deficient, l-amino acid-defined diet-fed rat model.
Topics: Amino Acids; Animals; Blotting, Western; Choline; Choline Deficiency; Diet; Disease Models, Animal; | 2010 |
Deletion of inducible nitric oxide synthase provides cardioprotection in mice with 2-kidney, 1-clip hypertension.
Topics: Animals; Blood Pressure; Disease Models, Animal; Fibrosis; Gene Deletion; Hypertension, Renovascular | 2009 |
Role of neuronal nitric oxide synthase in ovine sepsis model.
Topics: Animals; Disease Models, Animal; Female; Hemodynamics; Interleukin-6; Lung; Lung Injury; Nitrates; N | 2009 |
Naltrexone protects against lipopolysaccharide/D-galactosamine-induced hepatitis in mice.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Inju | 2008 |
Increased nitrite reductase activity of fetal versus adult ovine hemoglobin.
Topics: Animals; Biocatalysis; Chronic Disease; Disease Models, Animal; Dithionite; Female; Fetal Blood; Fet | 2009 |
Chronic hypoxia increases inducible NOS-derived nitric oxide in fetal guinea pig hearts.
Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Basic Helix-Loop-Helix Transcription Factor | 2009 |
EGCG inhibits proliferation of cardiac fibroblasts in rats with cardiac hypertrophy.
Topics: Angiotensin II; Animals; Antioxidants; Atrial Natriuretic Factor; Camellia sinensis; Cardiomegaly; C | 2009 |
[Effect of ethyl nitrite versus inhaled nitric oxide in a rat model of acute pulmonary hypertension].
Topics: Acute Disease; Administration, Inhalation; Animals; Disease Models, Animal; Hypertension, Pulmonary; | 2008 |
The levels of glutathione and nitrite-nitrate and the expression of Bcl-2 mRNA in ovariectomized rats treated by raloxifene against kainic acid.
Topics: Animals; Apoptosis; Disease Models, Animal; Female; Glutathione; Kainic Acid; Nerve Degeneration; Ne | 2009 |
Nitrite or sildenafil, but not BAY 41-2272, blunt acute pulmonary embolism-induced increases in circulating matrix metalloproteinase-9 and oxidative stress.
Topics: Acute Disease; Animals; Disease Models, Animal; Dogs; Female; Humans; Male; Matrix Metalloproteinase | 2009 |
Effects of 2,3,4',5-tetrahydroxystilbene 2-O-beta-D-glucoside on vascular endothelial dysfunction in atherogenic-diet rats.
Topics: Animals; Aorta; Atherosclerosis; Disease Models, Animal; Drugs, Chinese Herbal; Endothelium, Vascula | 2009 |
Suppression of diet-induced hypercholesterolemia by scutellarin in rats.
Topics: Animals; Anticholesteremic Agents; Apigenin; Cholesterol; Disease Models, Animal; Drugs, Chinese Her | 2009 |
The role of antioxidant properties of Nardostachys jatamansi in alleviation of the symptoms of the chronic fatigue syndrome.
Topics: Animals; Antioxidants; Anxiety; Brain; Catalase; Disease Models, Animal; Fatigue Syndrome, Chronic; | 2009 |
Neuroprotective effect of ghrelin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease by blocking microglial activation.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Animals, Newborn; Cells | 2009 |
Therapeutic window for cinnamophilin following oxygen-glucose deprivation and transient focal cerebral ischemia.
Topics: Analysis of Variance; Animals; Animals, Newborn; Antioxidants; Benzothiazoles; Body Weight; Cell Lin | 2009 |
Hyperglycemia contributes to cardiac dysfunction in a lipopolysaccharide-induced systemic inflammation model.
Topics: Animals; Cytokines; Disease Models, Animal; HMGB1 Protein; Hyperglycemia; Hypoglycemic Agents; Insul | 2009 |
Vascular caveolin deficiency supports the angiogenic effects of nitrite, a major end product of nitric oxide metabolism in tumors.
Topics: Analysis of Variance; Animals; Aorta; Caveolin 1; Cell Hypoxia; Disease Models, Animal; Down-Regulat | 2009 |
Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice.
Topics: Angiotensin II; Animals; Bilirubin; Blood Pressure; Cardiomegaly; Disease Models, Animal; Glucuronos | 2009 |
Topical anti-inflammatory effect of tirucallol, a triterpene isolated from Euphorbia lactea latex.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Dinoprostone; Disease Models, Animal; Do | 2010 |
Lonomia obliqua caterpillar envenomation causes platelet hypoaggregation and blood incoagulability in rats.
Topics: Animals; Arthropod Venoms; Blood Coagulation; Brazil; Disease Models, Animal; Fibrinogen; Hemorrhage | 2010 |
Protection against in vivo focal myocardial ischemia/reperfusion injury-induced arrhythmias and apoptosis by hesperidin.
Topics: Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Arrhythmias, Car | 2009 |
Nitroxyl exacerbates ischemic cerebral injury and oxidative neurotoxicity.
Topics: Animals; Blood Pressure; Brain Infarction; Cells, Cultured; Dinoprost; Disease Models, Animal; Dose- | 2009 |
Epigallocatechin gallate ameliorates chronic fatigue syndrome in mice: behavioral and biochemical evidence.
Topics: Animals; Antioxidants; Brucella abortus; Catalase; Catechin; Disease Models, Animal; Fatigue Syndrom | 2009 |
Role of macrophages in the development of pancreatic islet injury in spontaneously diabetic torii rats.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bone Density Conservation Agents; | 2009 |
Absence of functional Hfe protects mice from invasive Salmonella enterica serovar Typhimurium infection via induction of lipocalin-2.
Topics: Acute-Phase Proteins; Animals; Bacterial Proteins; Cells, Cultured; Cytokines; Disease Models, Anima | 2009 |
Effects of lipoic acid on oxidative stress in rat striatum after pilocarpine-induced seizures.
Topics: Animals; Antioxidants; Catalase; Convulsants; Corpus Striatum; Disease Models, Animal; Drug Interact | 2010 |
Protective effect of hesperidin and naringin against 3-nitropropionic acid induced Huntington's like symptoms in rats: possible role of nitric oxide.
Topics: Analysis of Variance; Animals; Antioxidants; Body Weight; Catalase; Corpus Striatum; Disease Models, | 2010 |
Involvement of NO-cGMP pathway in anti-anxiety effect of aminoguanidine in stressed mice.
Topics: Adaptation, Ocular; Analysis of Variance; Animals; Anti-Asthmatic Agents; Cyclic GMP; Disease Models | 2009 |
Medical ozone therapy reduces oxidative stress and intestinal damage in an experimental model of necrotizing enterocolitis in neonatal rats.
Topics: Animals; Animals, Newborn; Biomarkers; Disease Models, Animal; Enterocolitis, Necrotizing; Glutathio | 2009 |
Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis.
Topics: Acetylcholine; Animals; Aorta; Atorvastatin; Biological Factors; Blood Cell Count; Blood Pressure; C | 2009 |
Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms.
Topics: Animals; Antioxidants; Ascorbic Acid; Creatine Kinase; Disease Models, Animal; Female; Glutathione; | 2009 |
Evaluation of anti-angiogenic, anti-inflammatory and antinociceptive activity of coenzyme Q(10) in experimental animals.
Topics: Abdominal Pain; Analgesics; Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents; Capillary Pe | 2009 |
Cocaine-induced status epilepticus and death generate oxidative stress in prefrontal cortex and striatum of mice.
Topics: Animals; Antioxidants; Biomarkers; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Death, Sudde | 2010 |
Okadaic acid (ICV) induced memory impairment in rats: a suitable experimental model to test anti-dementia activity.
Topics: Animals; Brain; Calcium Signaling; Cholinesterase Inhibitors; Dementia; Disease Models, Animal; Done | 2010 |
Renal NOS activity, expression, and localization in male and female spontaneously hypertensive rats.
Topics: Animals; Cyclic GMP; Disease Models, Animal; Female; Hypertension; Kidney Cortex; Kidney Medulla; Ma | 2010 |
Effect of astaxanthin on hepatocellular injury following ischemia/reperfusion.
Topics: Alanine Transaminase; Animals; Antioxidants; Disease Models, Animal; Glutathione; Liver; Male; Nitra | 2010 |
Involvement of TRPV4-NO-cGMP-PKG pathways in the development of thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats.
Topics: Animals; Behavior, Animal; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Enz | 2010 |
Countervailing vascular effects of rosiglitazone in high cardiovascular risk mice: role of oxidative stress and PRMT-1.
Topics: Animals; Carotid Artery, Internal; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Drug E | 2010 |
Active ingredients of traditional Japanese (kampo) medicine, inchinkoto, in murine concanavalin A-induced hepatitis.
Topics: Animals; Artemisia; Chemical and Drug Induced Liver Injury; Chromones; Concanavalin A; Cytokines; Di | 2010 |
Chronic hyperammonemia induces tonic activation of NMDA receptors in cerebellum.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebellum; Cyclic GMP; Disease Models, | 2010 |
On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease.
Topics: Animals; Biomarkers; Disease Models, Animal; Inflammatory Bowel Diseases; Male; Mesalamine; Nitrates | 2010 |
An adequately robust early TNF-alpha response is a hallmark of survival following trauma/hemorrhage.
Topics: Animals; Disease Models, Animal; Female; Humans; Inflammation; Male; Middle Aged; Nitrates; Nitrites | 2009 |
Anti-ulcer role of herbomineral Siddha drug - Thamira parpam on experimentally induced gastric mucosal damage in rats.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Aspirin; Body Weight; Cytoprotection; Disease Models, Anim | 2010 |
Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction.
Topics: Animals; Anti-Inflammatory Agents; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Bifla | 2010 |
Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress.
Topics: Animals; Anxiety; Catalase; Chronic Disease; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; | 2010 |
Phenolic extract of soybean (Glycine max) attenuates cisplatin-induced nephrotoxicity in rats.
Topics: 5'-Nucleotidase; Acetylglucosaminidase; Acute Kidney Injury; Animals; Antineoplastic Agents; Antioxi | 2010 |
Gastroprotective effect of Saccharomyces boulardii in a rat model of ibuprofen-induced gastric ulcer.
Topics: Animals; Body Weight; Cytoprotection; Disease Models, Animal; Gastric Mucosa; Ibuprofen; Male; Nitra | 2010 |
Natural therapeutic magnesium lithospermate B potently protects the endothelium from hyperglycaemia-induced dysfunction.
Topics: Animals; Antioxidants; Apoptosis; Cell Adhesion; Cells, Cultured; Diabetes Mellitus, Type 2; Diabeti | 2010 |
Cepharanthine exerts anti-inflammatory effects via NF-κB inhibition in a LPS-induced rat model of systemic inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzylisoquinolines; Cell Line; Disease Models, An | 2011 |
Time course changes of oxidative stress markers in a rat experimental glaucoma model.
Topics: Animals; Antioxidants; Aqueous Humor; Biomarkers; Disease Models, Animal; Female; Glaucoma; Intraocu | 2010 |
Oral nitrite ameliorates dextran sulfate sodium-induced acute experimental colitis in mice.
Topics: Analysis of Variance; Animals; Blood Pressure; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease | 2010 |
Increased inducible nitric oxide synthase and arginase II expression in heart failure: no net nitrite/nitrate production and protein S-nitrosylation.
Topics: Animals; Arginase; Arginine; Blotting, Western; Cardiac Pacing, Artificial; Disease Models, Animal; | 2010 |
Beneficial effects of magnolol in a rodent model of endotoxin shock.
Topics: Animals; Antithrombin III; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Gene Expressi | 2010 |
Helminth coinfection does not affect therapeutic effect of a DNA vaccine in mice harboring tuberculosis.
Topics: Analysis of Variance; Animals; Bacterial Proteins; Chaperonin 60; Disease Models, Animal; Female; He | 2010 |
Involvement of nitric oxide in a rat model of carrageenin-induced pleurisy.
Topics: Animals; Antioxidants; Arginine; Carrageenan; Disease Models, Animal; Male; Malondialdehyde; Nitrate | 2010 |
Insulin resistance induced by a high-fructose diet potentiates thioacetamide hepatotoxicity.
Topics: Albumins; Animals; Antioxidants; Arginase; Bilirubin; Cytochrome P-450 CYP2E1; Dietary Carbohydrates | 2010 |
Time course of nitric oxide synthases, nitrosative stress, and poly(ADP ribosylation) in an ovine sepsis model.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Interleukin-8; Lung; Nitrates; Nitric Oxide Synt | 2010 |
Insulin treatment of diabetic rats reduces cardiac function in a lipopolysaccharide-induced systemic inflammation model.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Heart Diseases; Hea | 2011 |
Simvastatin effects on portal-systemic collaterals of portal hypertensive rats.
Topics: Animals; Arginine Vasopressin; Collateral Circulation; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprost | 2010 |
Indomethacin activates peroxisome proliferator-activated receptor γ to improve insulin resistance in cotton pellet granuloma model.
Topics: Adipose Tissue; Animals; Cell Movement; Cotton Fiber; Cyclooxygenase 2; Dinoprostone; Disease Models | 2010 |
Danaparoid sodium attenuates the effects of heat stress.
Topics: Acute Disease; Animals; Anticoagulants; Antithrombin III; Chondroitin Sulfates; Cytokines; Dermatan | 2011 |
Quercetin restores plasma nitrite and nitroso species levels in renovascular hypertension.
Topics: Animals; Antioxidants; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Hypertension, | 2010 |
Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: possible behavioral, biochemical, mitochondrial and tumor necrosis factor-α level alterations in rats.
Topics: Acetates; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Brain; Brain Chemistry; Cata | 2010 |
Chronic ethanol consumption-induced pancreatic {beta}-cell dysfunction and apoptosis through glucokinase nitration and its down-regulation.
Topics: Alcoholism; Animals; Apoptosis; Cell Line; Disease Models, Animal; Down-Regulation; Ethanol; Glucoki | 2010 |
Ramipril-like activity of Spondias mombin linn against no-flow ischemia and isoproterenol-induced cardiotoxicity in rat heart.
Topics: Anacardiaceae; Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiovascular Agents; Catalase; C | 2010 |
Asymmetric dimethylarginine potentiates lung inflammation in a mouse model of allergic asthma.
Topics: Amidohydrolases; Animals; Arginine; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; En | 2010 |
Role of mouse cerebellar nicotinic acetylcholine receptor (nAChR) α(4)β(2)- and α(7) subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Benzamides; Bridged Bicyclo Comp | 2011 |
Effects of long term nitrite therapy on functional recovery in experimental ischemia model.
Topics: Animals; Brain Ischemia; Caspases; Cytokines; Disease Models, Animal; Female; Humans; Neovasculariza | 2010 |
Mesenteric vascular remodeling in hyperhomocysteinemia.
Topics: Abdominal Pain; Amidohydrolases; Animals; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blo | 2011 |
Homocysteine induces oxidative-nitrative stress in heart of rats: prevention by folic acid.
Topics: Animals; Antioxidants; Catalase; Disease Models, Animal; Female; Fluoresceins; Folic Acid; Heart Dis | 2011 |
Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?
Topics: Aerosols; Animals; Arginase; Arginine; Asthma; Blotting, Western; Coloring Agents; Disease Models, A | 2010 |
Attenuation of proinflammatory cytokines and apoptotic process by verapamil and diltiazem against quinolinic acid induced Huntington like alterations in rats.
Topics: Analysis of Variance; Animals; Apoptosis; Body Weight; Calcium Channel Blockers; Catalase; Cytokines | 2011 |
Effects of agmatine on hypoxic microglia and activity of nitric oxide synthase.
Topics: Agmatine; Analysis of Variance; Animals; Calcium-Binding Proteins; Cell Hypoxia; Cell Line, Transfor | 2011 |
Arginase inhibition restores in vivo coronary microvascular function in type 2 diabetic rats.
Topics: Amino Acids; Animals; Arginase; Arginine; Blood Flow Velocity; Blood Glucose; Coronary Circulation; | 2011 |
Protective effects of synthetic kynurenines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Cytosol; Disease Models, Ani | 2011 |
Galantamine potentiates the protective effect of rofecoxib and caffeic acid against intrahippocampal Kainic acid-induced cognitive dysfunction in rat.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Brain; Caffeic Acids; Cognition Disorders; Dise | 2011 |
Insights into the effect of nitric oxide and its metabolites nitrite and nitrate at inhibiting neointimal hyperplasia.
Topics: Animals; Cell Proliferation; Cells, Cultured; Coronary Artery Disease; Disease Models, Animal; Hyper | 2011 |
Azelnidipine, a new calcium channel blocker, promotes skin wound healing in diabetic rats.
Topics: Animals; Azetidinecarboxylic Acid; Calcium Channel Blockers; Diabetes Mellitus, Experimental; Dihydr | 2011 |
Manganese porphyrin reduces retinal injury induced by ocular hypertension in rats.
Topics: Animals; Antioxidants; Blotting, Western; Disease Models, Animal; Electrophoresis, Polyacrylamide Ge | 2011 |
Catechin suppresses an array of signalling molecules and modulates alcohol-induced endotoxin mediated liver injury in a rat model.
Topics: Alcohols; Animals; Antioxidants; Catechin; Cell Nucleus; Chemical and Drug Induced Liver Injury; Dis | 2011 |
Development of an animal model for chronic mild hyperhomocysteinemia and its response to oxidative damage.
Topics: Animals; Antioxidants; Catalase; Cerebral Cortex; Disease Models, Animal; Glutathione Peroxidase; Ho | 2011 |
Aorta from angiotensin II hypertensive mice exhibit preserved nitroxyl anion mediated relaxation responses.
Topics: Acetylcholine; Angiotensin II; Animals; Aorta; Blood Pressure; Disease Models, Animal; Dose-Response | 2012 |
Interplay of endothelial and inducible nitric oxide synthases modulates the vascular response to ischaemia-reperfusion in the rabbit lung.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Lung; NADPH Oxidases; Nitrates; Nitric Oxide; Ni | 2012 |
Reversal of cerebral vasospasm via intravenous sodium nitrite after subarachnoid hemorrhage in primates.
Topics: Animals; Cerebral Angiography; Disease Models, Animal; Infusions, Intravenous; Macaca fascicularis; | 2011 |
Nitrite attenuates ischemia-reperfusion-induced microcirculatory alterations and mitochondrial dysfunction in the microvasculature of skeletal muscle.
Topics: Analysis of Variance; Animals; Cytochromes c; Disease Models, Animal; Dose-Response Relationship, Dr | 2011 |
Vascular hyporeactivity to angiotensin II and noradrenaline in a rabbit model of obesity.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Blood Glucose; Blood Pressure; Diet, High-Fat; Disease Mod | 2012 |
Dose-related effects of hyperoxia on the lung inflammatory response in septic rats.
Topics: Animals; CD11 Antigens; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Re | 2012 |
Vascular contribution of adrenomedullin to microcirculatory improvement in experimental colitis.
Topics: Adrenomedullin; Animals; Biomarkers; Colitis; Cyclooxygenase 2; Disease Models, Animal; Gene Express | 2011 |
Microglia-inhibiting activity of Parkinson's disease drug amantadine.
Topics: Amantadine; Analysis of Variance; Animals; Antiparkinson Agents; Calcium-Binding Proteins; Cell Line | 2012 |
Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Cell Line; Diazoxi | 2011 |
Polydeoxyribonucleotide restores blood flow in an experimental model of ischemic skin flaps.
Topics: Adenosine A2 Receptor Agonists; Animals; Blood Flow Velocity; Dermatologic Surgical Procedures; Dise | 2012 |
Melatonin ameliorates necrotizing enterocolitis in a neonatal rat model.
Topics: Animals; Animals, Newborn; Antioxidants; Cold Temperature; Disease Models, Animal; Drug Evaluation, | 2011 |
Ruscogenin inhibits lipopolysaccharide-induced acute lung injury in mice: involvement of tissue factor, inducible NO synthase and nuclear factor (NF)-κB.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Lipopolysaccharides; M | 2012 |
Requirement of argininosuccinate lyase for systemic nitric oxide production.
Topics: Animals; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Argininosuccinic Aciduria; C | 2011 |
Endotoxin-induced acute lung injury is dependent upon oxidative response.
Topics: Acetylcysteine; Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Catalase; Cy | 2011 |
Subtotal nephrectomy plus coronary ligation leads to more pronounced damage in both organs than either nephrectomy or coronary ligation.
Topics: Animals; Blood Pressure; Cardio-Renal Syndrome; Coronary Stenosis; Disease Models, Animal; Gene Expr | 2012 |
Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Boswellia; Carrageenan; Chromatography, Liquid; Commi | 2012 |
Antihypertensive and antioxidant effects of a single daily dose of sodium nitrite in a model of renovascular hypertension.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Catalase; Cyclic GMP; Disease Models | 2012 |
Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta; Ascorbic Acid; Blood Pressure; Body Weight; Desoxycorticost | 2012 |
Targeting neuro-inflammatory cytokines and oxidative stress by minocycline attenuates quinolinic-acid-induced Huntington's disease-like symptoms in rats.
Topics: Analysis of Variance; Animals; Body Weight; Catalase; Cytokines; Disease Models, Animal; Dose-Respon | 2012 |
The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Aspartate Aminotransferases; | 2012 |
Inhibition of hypoxia inducible factor-1α ameliorates lung injury induced by trauma and hemorrhagic shock in rats.
Topics: Animals; Apoptosis; Bronchoalveolar Lavage Fluid; Caspase 3; Cytoprotection; Disease Models, Animal; | 2012 |
Physiologic responses to severe hemorrhagic shock and the genesis of cardiovascular collapse: can irreversibility be anticipated?
Topics: Animals; Autonomic Nervous System; Blood Pressure; Catecholamines; Cytokines; Disease Models, Animal | 2012 |
Cysteinyl leukotriene receptor antagonism alleviates renal injury induced by ischemia-reperfusion in rats.
Topics: Animals; Disease Models, Animal; Indoles; Intercellular Adhesion Molecule-1; Kidney Diseases; Leukot | 2012 |
Noninvasive limb remote ischemic preconditioning contributes neuroprotective effects via activation of adenosine A1 receptor and redox status after transient focal cerebral ischemia in rats.
Topics: Adenosine; Analysis of Variance; Animals; Brain Infarction; Diffusion Magnetic Resonance Imaging; Di | 2012 |
Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase.
Topics: Allopurinol; Animal Feed; Animals; Antibiotics, Antineoplastic; Bleomycin; Cyclic GMP; Disease Model | 2012 |
Nitrite reduces ischemia/reperfusion-induced muscle damage and improves survival rates in rat crush injury model.
Topics: Analysis of Variance; Animals; Blood Pressure Determination; Crush Syndrome; Disease Models, Animal; | 2012 |
Enhanced estradiol-induced vasorelaxation in aortas from type 2 diabetic mice may reflect a compensatory role of p38 MAPK-mediated eNOS activation.
Topics: Animals; Aorta; Diabetes Mellitus, Type 2; Disease Models, Animal; Estradiol; Estrogens; Female; In | 2012 |
Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms.
Topics: Amphetamine; Analysis of Variance; Animals; Atorvastatin; Corpus Striatum; Disease Models, Animal; D | 2012 |
Anti-tumor-promoting activities of agaro-oligosaccharides on two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Agar; Animals; Antineoplastic Agents; Carcinogens; Cyclooxygenase | 2012 |
The differential role of NOS inhibitors on stress-induced anxiety and neuroendocrine alterations in the rat.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Brain; Corticosterone; Disease Models, | 2012 |
Bax and B-cell-lymphoma 2 mediate proapoptotic signaling following chronic isolation stress in rat brain.
Topics: Analysis of Variance; Animals; bcl-2-Associated X Protein; Brain; Corticosterone; Cytosol; Disease M | 2012 |
Direct renin inhibitor prevents and ameliorates insulin resistance, aortic endothelial dysfunction and vascular remodeling in fructose-fed hypertensive rats.
Topics: Amides; Animals; Aorta, Thoracic; Dietary Carbohydrates; Disease Models, Animal; Endothelium, Vascul | 2013 |
Muscimol delays lipopolysaccharide-induced preterm delivery in mice: role of GABA(A) receptors and nitric oxide.
Topics: Amniotic Fluid; Animals; Bicuculline; Disease Models, Animal; Female; GABA-A Receptor Agonists; GABA | 2013 |
A combination of vitamin C and losartan for cisplatin-induced nephrotoxicity in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Blood Pro | 2012 |
Dietary nitrate supplementation improves revascularization in chronic ischemia.
Topics: Animal Feed; Animals; Bone Marrow Transplantation; Cell Movement; Chronic Disease; Cyclic GMP; Dieta | 2012 |
Protective effects of ebselen on sodium-selenite-induced experimental cataract in rats.
Topics: Animals; Antioxidants; Azoles; Cataract; Disease Models, Animal; Glutathione; Isoindoles; Lens, Crys | 2012 |
Coenzyme q10 ameliorates neurodegeneration, mossy fiber sprouting, and oxidative stress in intrahippocampal kainate model of temporal lobe epilepsy in rat.
Topics: Animals; Cell Death; Disease Models, Animal; Epilepsy, Temporal Lobe; Kainic Acid; Malondialdehyde; | 2013 |
Nitrite reduces acute lung injury and improves survival in a rat lung transplantation model.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Graft Rejection; Graft Survival; Lung Transplant | 2012 |
A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cytokines; Disease Models, Animal; Dose-Res | 2013 |
The inhibitory effect of S-nitrosoglutathione on blood-brain barrier disruption and peroxynitrite formation in a rat model of experimental stroke.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Carrier Proteins; Disease Models, Animal; E-Select | 2012 |
Downregulation of oxidative and nitrosative apoptotic signaling by L-carnitine in Ifosfamide-induced Fanconi syndrome rat model.
Topics: Animals; Apoptosis; Blood Urea Nitrogen; Carnitine; Caspases; Catalase; Creatinine; Disease Models, | 2012 |
The antiprotozoal drug pentamidine ameliorates experimentally induced acute colitis in mice.
Topics: Animals; Antiprotozoal Agents; Colitis; Colon; Cyclooxygenase 2; Dextran Sulfate; Dinoprostone; Dise | 2012 |
The aerial part of Taraxacum coreanum extract has an anti-inflammatory effect on peritoneal macrophages in vitro and increases survival in a mouse model of septic shock.
Topics: Animals; Anti-Inflammatory Agents; Asteraceae; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Cyt | 2013 |
Hypertonic saline solution reduces the inflammatory response in endotoxemic rats.
Topics: Animals; Disease Models, Animal; Endotoxemia; Hemodynamics; Inflammation Mediators; Inflammatory Bow | 2012 |
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Mo | 2013 |
Molecular mechanism of anti-inflammatory activity of Pluchea indica leaves in macrophages RAW 264.7 and its action in animal models ofinflammation.
Topics: Alkynes; Animals; Anti-Inflammatory Agents; Asteraceae; Carrageenan; Cell Line; Cell Survival; Dinop | 2013 |
The effects of taurine and thiotaurine on oxidative stress in the aorta and heart of diabetic rats.
Topics: Animals; Aorta; Blood Glucose; Catalase; Cholesterol; Diabetes Mellitus, Experimental; Disease Model | 2013 |
Endothelial NOS (NOS3) impairs myocardial function in developing sepsis.
Topics: Animals; Arterial Pressure; Cardiac Output; Cardiomyopathies; Coronary Circulation; Disease Models, | 2013 |
Effect of morphine on the reduced uteroplacental perfusion model of pre-eclampsia in rats.
Topics: Animals; Antihypertensive Agents; Disease Models, Animal; Enzyme Inhibitors; Female; Fetal Developme | 2013 |
[Protective effect of Ginkgo biloba extract on acute lung injury induced by lipopolysaccharide in D-galactose aging rats].
Topics: Aging; Animals; Disease Models, Animal; Endothelin-1; Galactose; Ginkgo biloba; Lipopolysaccharides; | 2002 |
Kallikrein gene delivery improves cardiac reserve and attenuates remodeling after myocardial infarction.
Topics: Adenoviridae; Animals; Apoptosis; Cell Survival; Disease Models, Animal; Dobutamine; Gene Transfer T | 2002 |
Immunomodulation of experimental autoimmune encephalomyelitis in the Lewis rats by Lovastatin.
Topics: Animals; Cell Culture Techniques; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimenta | 2002 |
Erythropoietin and interleukin-1beta modulate nitrite production in a Swiss 3T3 cell model of rheumatoid synovial fibroblasts.
Topics: 3T3 Cells; Animals; Arthritis, Rheumatoid; Disease Models, Animal; Erythropoietin; Fibroblasts; Huma | 2002 |
Resuscitation with Ringer's ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentrations in a rat model of lipopolysaccharide-induced shock.
Topics: Animals; Cytokines; Disease Models, Animal; Isotonic Solutions; Lactic Acid; Lipopolysaccharides; Ma | 2002 |
L-NAME reduces infarction, neurological deficit and blood-brain barrier disruption following cerebral ischemia in mice.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Brain Ischemia; Disease Models, Animal; Enzyme | 2002 |
Cyclooxygenase-2 inhibition attenuates lipopolysaccharide-induced cardiovascular failure.
Topics: Animals; Blood Pressure; Cardiovascular Diseases; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase | 2002 |
Effects of nebulized diethylenetetraamine-NONOate in a mouse model of acute Pseudomonas aeruginosa pneumonia.
Topics: Acute Disease; Aerosols; Animals; Disease Models, Animal; Hydrazines; Lung; Male; Mice; Mice, Inbred | 2002 |
Effect of NOS2 gene deficiency on the development of autoantibody mediated arthritis and subsequent articular cartilage degeneration.
Topics: Animals; Antibodies, Monoclonal; Arthritis, Experimental; Autoantibodies; Cartilage, Articular; Chon | 2003 |
Long-term dietary L-arginine supplementation attenuates proteinuria and focal glomerulosclerosis in experimental chronic renal transplant failure.
Topics: Animals; Arginine; Blood Pressure; Creatine; Dietary Supplements; Disease Models, Animal; Glomerulos | 2003 |
The effect of different hypertension models on visual evoked potentials.
Topics: Animals; Disease Models, Animal; Evoked Potentials, Visual; Fluorometry; Hippocampus; Hypertension; | 2002 |
The inducible nitric oxide synthase inhibitor BBS-2 prevents acute lung injury in sheep after burn and smoke inhalation injury.
Topics: Animals; Blood Pressure; Body Surface Area; Burns; Disease Models, Animal; Enzyme Inhibitors; Extrav | 2003 |
The protective effect of N-acetylcysteine on apoptotic lung injury in cecal ligation and puncture-induced sepsis model.
Topics: Acetylcysteine; Animals; Apoptosis; Cecum; Disease Models, Animal; Intestinal Perforation; Ligation; | 2003 |
Nicotinamide increases systemic vascular resistance in ovine endotoxemia.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bilirubin; Chronic Disease; Disease Mode | 2003 |
The role of nitric oxide synthase isoforms in extrahepatic portal hypertension: studies in gene-knockout mice.
Topics: Animals; Aorta, Abdominal; Disease Models, Animal; Hypertension, Portal; Ligation; Liver Circulation | 2003 |
LAAE-14, a new in vitro inhibitor of intracellular calcium mobilization, modulates acute and chronic inflammation.
Topics: Acute Disease; Animals; Arthritis, Experimental; Calcium; Carrageenan; Cell Movement; Chronic Diseas | 2003 |
Effect of round window membrane application of nitric oxide on hearing and nitric oxide concentration in perilymph.
Topics: Animals; Chinchilla; Cochlea; Disease Models, Animal; Female; Hearing; Hearing Loss; Hearing Tests; | 2003 |
Effects of cyclooxygenase inhibitors on nitric oxide production and survival in a mice model of sepsis.
Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Diclofenac; | 2003 |
Species-specific modulation of the nitric oxide pathway after acute experimentally induced endotoxemia.
Topics: Amidines; Animals; Benzylamines; Blood Pressure; Breath Tests; Disease Models, Animal; Drug Evaluati | 2003 |
Diabetes undermines estrogen control of inducible nitric oxide synthase function in rat aortic smooth muscle cells through overexpression of estrogen receptor-beta.
Topics: Animals; Aorta; Cells, Cultured; Cytokines; Diabetes Mellitus, Experimental; Disease Models, Animal; | 2003 |
Caffeic acid phenethyl ester (CAPE) prevents inflammatory stress in organotypic hippocampal slice cultures.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Antioxidants; Caenorhabditis elegans Proteins; | 2003 |
The role of inducible nitric oxide synthase inhibitor on the arteriolar hyporesponsiveness in hemorrhagic-shocked rats.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; | 2003 |
[Tricarboxylic acid cycle in energy metabolism and antioxidant cell defense in acute hypoxia].
Topics: Acute Disease; Animals; Antioxidants; Catalase; Cholinergic Antagonists; Citric Acid Cycle; Disease | 2003 |
[The effects of L-arginine and NG-nitro-L-arginine methylester on lipopolysaccharide and lipoteichoic acid induced liver injury in the rat].
Topics: Animals; Arginine; Disease Models, Animal; Enzyme Inhibitors; Lipopolysaccharides; Liver; Liver Func | 2003 |
Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia-induced pulmonary hypertension.
Topics: Amidohydrolases; Animals; Arginine; Blotting, Western; Chronic Disease; Disease Models, Animal; Enzy | 2003 |
The effect of alprostadil on ischemia-reperfusion injury of peripheral nerve in rats.
Topics: Alprostadil; Animals; Disease Models, Animal; Femoral Artery; Femoral Vein; Injections, Intravenous; | 2004 |
A new chloroquinolinyl chalcone derivative as inhibitor of inflammatory and immune response in mice and rats.
Topics: Abdominal Injuries; Administration, Oral; Animals; Arthritis, Experimental; Blood Platelets; Cell Li | 2003 |
Antioxidative, antinitrative, and vasculoprotective effects of a peroxisome proliferator-activated receptor-gamma agonist in hypercholesterolemia.
Topics: Animals; Antioxidants; Blood Vessels; Carotid Arteries; Cyclic GMP; Cyclic GMP-Dependent Protein Kin | 2003 |
Selective inhibition of nitric oxide in hypoxic-ischemic brain model in newborn rats: is it an explanation for the protective role of erythropoietin?
Topics: Animals; Brain Chemistry; Brain Diseases; Carotid Arteries; Disease Models, Animal; Erythropoietin; | 2004 |
Reactive nitrogen species scavenging, rather than nitric oxide inhibition, protects from articular cartilage damage in rat zymosan-induced arthritis.
Topics: Animals; Arthritis, Experimental; Cartilage, Articular; Disease Models, Animal; Dose-Response Relati | 2004 |
Protective effect of polyunsaturated phosphatidylcholine pretreatment on stress ulcer formation in rats.
Topics: Animals; Catalase; Cold Temperature; Disease Models, Animal; Female; Gastric Mucosa; Male; Malondial | 2004 |
Effects of intrarectal and intraperitoneal N(G)-nitro-L-arginine methyl ester treatment in 2,4,6-trinitrobenzenesulfonic acid induced colitis in rats.
Topics: Acute Disease; Administration, Rectal; Animals; Colitis; Disease Models, Animal; Drug Therapy, Combi | 2003 |
Role of the W07-toxin on Vibrio cholerae-induced diarrhoea.
Topics: Animals; Bacterial Toxins; Calcium; Catalase; Cells, Cultured; Citrulline; Diarrhea; Disease Models, | 2004 |
A nitric oxide-releasing derivative of enalapril, NCX 899, prevents progressive cardiac dysfunction and remodeling in hamsters with heart failure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Cardiomyopathy, Dilated; Cricetinae; Cytos | 2004 |
Neurons and astrocytes respond to prion infection by inducing microglia recruitment.
Topics: Animals; Astrocytes; Cell Count; Cell Movement; Cells, Cultured; Chemokines; Disease Models, Animal; | 2004 |
Effects of GW274150, a novel and selective inhibitor of iNOS activity, in acute lung inflammation.
Topics: Animals; Carrageenan; Disease Models, Animal; Enzyme Inhibitors; Intercellular Adhesion Molecule-1; | 2004 |
Additional evidence of acute anti-inflammatory effects of cyclosporin A in a murine model of pleurisy.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Chemotaxis, Leukocyte; Cyclosporine; Disease Models, | 2004 |
Anti-allergic activity of 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide.
Topics: Administration, Oral; Animals; Anti-Allergic Agents; beta-N-Acetylhexosaminidases; Cell Line; Dermat | 2004 |
Spermine reduces infarction and neurological deficit following a rat model of middle cerebral artery occlusion: a magnetic resonance imaging study.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Brain Infarction; Brain Mapping; D | 2004 |
Antioxidant enzyme activity and mRNA expression in the islets of Langerhans from the BB/S rat model of type 1 diabetes and an insulin-producing cell line.
Topics: Animals; Antioxidants; Catalase; Cell Line; Cytokines; Diabetes Mellitus, Type 1; Disease Models, An | 2004 |
l-Deprenyl prevents lipid peroxidation and memory deficits produced by cerebral ischemia in rats.
Topics: Animals; Antioxidants; Avoidance Learning; Brain Ischemia; Disease Models, Animal; Dose-Response Rel | 2004 |
Pathophysiology of vascular dysfunction in a rat model of chronic joint inflammation.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Body Weigh | 2004 |
Experimental cholestatic liver disease through bile-duct ligation in rats results in skeletal fragility and impaired osteoblastogenesis.
Topics: Animals; Bile Ducts; Bone Density; Bone Marrow Cells; Cell Division; Cells, Cultured; Cholestasis, I | 2004 |
Transduction of NO-bioactivity by the red blood cell in sepsis: novel mechanisms of vasodilation during acute inflammatory disease.
Topics: Acute Disease; Animals; Cecum; Disease Models, Animal; Erythrocytes; Hemoglobins; Ligation; Lipopoly | 2004 |
Sequential changes in redox status and nitric oxide synthases expression in the liver after bile duct ligation.
Topics: Animals; Bile Ducts, Extrahepatic; Blood Pressure; Blotting, Western; Disease Models, Animal; Hydrox | 2004 |
Sleep-wake architecture in mouse models for Down syndrome.
Topics: Animals; Brain Stem; Cerebral Cortex; Disease Models, Animal; Down Syndrome; Mice; Mice, Transgenic; | 2004 |
Suppression of cytokine-inducible nitric oxide synthesis during intraperitoneal Meth A tumor growth.
Topics: Animals; Ascites; Cell Line, Tumor; Cytokines; Disease Models, Animal; Electron Spin Resonance Spect | 2004 |
Oral administration of Crataegus flavonoids protects against ischemia/reperfusion brain damage in gerbils.
Topics: Administration, Oral; Animals; Antioxidants; Brain Chemistry; Cell Nucleus; Crataegus; Disease Model | 2004 |
Involvement of steroids in anti-inflammatory effects of PK11195 in a murine model of pleurisy.
Topics: Adenosine Deaminase; Aminoglutethimide; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Ca | 2004 |
Upregulation of endothelial nitric oxide synthase maintains nitric oxide production in the cerebellum of thioacetamide cirrhotic rats.
Topics: Animals; Blotting, Western; Cerebellum; Disease Models, Animal; Gene Expression Regulation, Enzymolo | 2004 |
Nuclear factor-kappaB regulates inflammatory cell apoptosis and phagocytosis in rat carrageenin-sponge implant model.
Topics: Animals; Apoptosis; Blotting, Western; Carrageenan; Cell Movement; Disease Models, Animal; Enzyme-Li | 2004 |
Effects of epicatechin gallate on wound healing and scar formation in a full thickness incisional wound healing model in rats.
Topics: Animals; Arginase; Blotting, Western; Catechin; Cicatrix; Cyclooxygenase 2; Disease Models, Animal; | 2004 |
Effects of aminoguanidine and L-arginine methyl ester resuscitation following induction of fluid-percussion injury and severe controlled hemorrhagic shock in the rat brain.
Topics: Animals; Blood Pressure; Brain; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; | 2004 |
Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury.
Topics: Agmatine; Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Brain Infarction; Cell | 2004 |
Denitrification genes regulate Brucella virulence in mice.
Topics: Adaptation, Physiological; Agrobacterium tumefaciens; Animals; Anion Transport Proteins; Artificial | 2004 |
Nitric oxide-releasing aspirin derivative, NCX 4016, promotes reparative angiogenesis and prevents apoptosis and oxidative stress in a mouse model of peripheral ischemia.
Topics: Animals; Apoptosis; Aspirin; Disease Models, Animal; Down-Regulation; Gene Expression Regulation; Ma | 2004 |
Protective effects of the Chinese prescription Hachimi-jio-gan against diabetic oxidative stress.
Topics: Animals; Blood Glucose; Blood Proteins; Creatinine; Diabetes Mellitus, Experimental; Disease Models, | 2004 |
Inhibitory effects of proanthocyanidins from Ribes nigrum leaves on carrageenin acute inflammatory reactions induced in rats.
Topics: Animals; Carrageenan; Cytokines; Disease Models, Animal; Edema; Inflammation; Male; Nitrates; Nitrit | 2004 |
The effects of hyaluronan on bone resorption and bone mineral density in a rat model of estrogen deficiency-induced osteopenia.
Topics: Amino Acids; Animals; Body Weight; Bone Density; Bone Diseases, Metabolic; Bone Resorption; Disease | 2004 |
The expression of heme oxygenase-1 and inducible nitric oxide synthase in aorta during the development of hypertension in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta; Biomarkers; Blood Pressure; Blotting, Western; Disease Mode | 2004 |
Local and systemic expression of inducible nitric oxide synthase in comparison with that of cyclooxygenase-2 in rat carrageenin-induced pleurisy.
Topics: Animals; Carrageenan; Cell Count; Cyclooxygenase 2; Disease Models, Animal; Immunohistochemistry; Le | 2005 |
Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage.
Topics: Animals; Cerebral Angiography; Disease Models, Animal; Infarction, Middle Cerebral Artery; Infusions | 2005 |
[Role of nitric oxide and lipid peroxidation in pathogenesis of acute experimental pancreatitis].
Topics: Animals; Arginine; Disease Models, Animal; Lipid Peroxidation; Lipid Peroxides; Male; Methylene Blue | 2005 |
Role of oxidative stress in the pathogenesis of septic ileus in mice.
Topics: Aldehydes; Animals; Antioxidants; Catalase; Disease Models, Animal; Gastric Emptying; Gastrointestin | 2005 |
Effects of chronic quercetin treatment in experimental renovascular hypertension.
Topics: Animals; Antioxidants; Aorta; Blood Pressure; Body Weight; Diet; Disease Models, Animal; Dose-Respon | 2005 |
Relationship between iNOS expression and aortic cell proliferation and apoptosis in an elastase-induced model of aorta aneurysm and the effect of 1400 W administration.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Apoptosis; Cell Division; Disease Models, Ani | 2005 |
Development and validation of a novel IL-10 deficient cell transfer model for colitis.
Topics: Adrenal Cortex Hormones; Animals; Antibodies, Monoclonal; Cell Transplantation; Disease Models, Anim | 2005 |
[Decrease of nitric oxide (NO)-cGMP-dependent vasodilatation in the vessels of lesser circulation in endothelial dysfunction].
Topics: Animals; Cyclic GMP; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Guanidines; H | 2005 |
Placental dysfunction in Suramin-treated rats--a new model for pre-eclampsia.
Topics: Angiogenesis Inhibitors; Animals; Blood Pressure; Disease Models, Animal; Electrolytes; Endothelin-1 | 2005 |
The anti-inflammatory effect of inhaled nitric oxide on pulmonary inflammation in a swine model.
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents; Apoptosis; Bronchoalveolar Lavage Flu | 2005 |
Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress.
Topics: Acetophenones; Angiotensin II; Animals; Antioxidants; Aorta, Thoracic; Biopterins; Cardiomegaly; Dis | 2005 |
Lipid peroxidation inhibition by raxofelast improves angiogenesis and wound healing in experimental burn wounds.
Topics: Animals; Benzofurans; Burns; Disease Models, Animal; Glutathione; Immunohistochemistry; Lipid Peroxi | 2005 |
The signal transduction pathways involved in hepatic cytochrome P450 regulation in the rat during a lipopolysaccharide-induced model of central nervous system inflammation.
Topics: Animals; Brain; Central Nervous System; CREB-Binding Protein; Cytochrome P-450 Enzyme System; Diseas | 2005 |
Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2 cause potent neuroprotection after experimental stroke through noncompletely overlapping mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Disease Models, Animal; Drug Administration Sch | 2006 |
Effects of MK-801 on nitrite and cGMP levels during focal cerebral ischemia in rats.
Topics: Animals; Brain; Brain Ischemia; Cyclic GMP; Disease Models, Animal; Dizocilpine Maleate; Male; Nitri | 2005 |
Ibuprofen reduces plasma nitrite/nitrate levels in a rabbit model of endotoxin-induced shock.
Topics: Animals; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Hypotension; Ibuprofen; | 2005 |
Arterial hypoxemia and intrapulmonary vasodilatation in rat models of portal hypertension.
Topics: Animals; Arteries; Disease Models, Animal; Endothelin-1; Hepatopulmonary Syndrome; Hypertension, Por | 2005 |
Ethyl pyruvate improves systemic and hepatosplanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia.
Topics: Acidosis; Animals; Blood Pressure; Disease Models, Animal; Diuresis; Endotoxemia; Hemodynamics; Lipi | 2005 |
Pulmonary and systemic nitric oxide metabolites in a baboon model of neonatal chronic lung disease.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Chronic Disease; Cysteine; Disease Models, An | 2005 |
DSS-induced colitis is exacerbated in STAT-6 knockout mice.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Interferon-gamma; Mice; Mice, Inbred BALB | 2005 |
A novel nitric oxide-releasing statin derivative exerts an antiplatelet/antithrombotic activity and inhibits tissue factor expression.
Topics: Animals; Blood Platelets; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; In Vitro | 2005 |
Nitrosative stress in an animal model of necrotizing enterocolitis.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Enterocolitis, Necrotizing; Humans; Hypoxia; Ileu | 2005 |
Beneficial effects of concurrent autologous bone marrow cell therapy and metabolic intervention in ischemia-induced angiogenesis in the mouse hindlimb.
Topics: Animals; Antioxidants; Arginine; Bone Marrow Transplantation; Disease Models, Animal; Fluorescent An | 2005 |
Possible role of nitric oxide in the protective effect of resveratrol in 5/6th nephrectomized rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Blood Pressure; Body Weight; Disease Models, Animal; Eat | 2006 |
Postischemic infusion of adrenomedullin protects against ischemic stroke by inhibiting apoptosis and promoting angiogenesis.
Topics: Adrenomedullin; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; B | 2006 |
Salutary effects of estrogen receptor-beta agonist on lung injury after trauma-hemorrhage.
Topics: Analysis of Variance; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Estradiol; Estr | 2006 |
Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats.
Topics: Animals; Arginine; Behavior, Animal; Cold Temperature; Constriction, Pathologic; Disease Models, Ani | 2006 |
The inflammatory transcriptome of reactive murine astrocytes and implications for their innate immune function.
Topics: Animals; Animals, Newborn; Astrocytes; Cell Cycle; Cell Death; Cells, Cultured; Cerebral Cortex; Che | 2006 |
Ginkgo biloba inhibits bleomycin-induced lung fibrosis in rats.
Topics: Animals; Antioxidants; Bleomycin; Bronchoalveolar Lavage Fluid; Catalase; Disease Models, Animal; Gi | 2006 |
The effect of resveratrol in experimental cataract model formed by sodium selenite.
Topics: Animals; Antioxidants; Cataract; Disease Models, Animal; Glutathione; Lens, Crystalline; Lipid Perox | 2006 |
Hemodynamic effects of sildenafil interaction with a nitric oxide donor compound in a dog model of acute pulmonary embolism.
Topics: Animals; Blood Pressure; Cyclic GMP; Disease Models, Animal; Dogs; Drug Interactions; Female; Heart | 2006 |
IFN-gamma: regulation of nitric oxide in the P. aeruginosa-infected cornea.
Topics: Animals; Colony Count, Microbial; Cornea; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Enzy | 2006 |
Transcranial magnetic stimulation attenuates cell loss and oxidative damage in the striatum induced in the 3-nitropropionic model of Huntington's disease.
Topics: Animals; Catalase; Cell Count; Cell Death; Corpus Striatum; Disease Models, Animal; Glutathione; Hun | 2006 |
Endothelially derived nitric oxide affects the severity of early acetaminophen-induced hepatic injury in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Disease Models | 2006 |
Attenuation of endotoxin-induced oxidative stress and multiple organ injury by 3,4-Methylenedioxyphenol in rats.
Topics: Animals; Antioxidants; Benzodioxoles; Disease Models, Animal; Endotoxins; Kidney; Lipopolysaccharide | 2006 |
Reduction in oxidative stress and cell death explains hypothyroidism induced neuroprotection subsequent to ischemia/reperfusion insult.
Topics: Animals; Brain Infarction; Calcium; Catalase; Cell Death; Disease Models, Animal; Hypothyroidism; Im | 2006 |
LL-37 protects rats against lethal sepsis caused by gram-negative bacteria.
Topics: Animals; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Cathelicidins; Cecum; Disease Model | 2006 |
Effects of verapamil and nifedipine on different parameters in lipopolysaccharide-induced septic shock.
Topics: Animals; Calcium Channel Blockers; Carotid Arteries; Catalase; Disease Models, Animal; Interleukin-1 | 2006 |
Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats.
Topics: Animals; Antithrombins; Arachidonic Acids; Blood Pressure; Calcitonin Gene-Related Peptide; Calciton | 2006 |
Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure.
Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Biomarkers; Cecum; Cytokines; Disease Models, A | 2006 |
Recombinant human activated protein C improves pulmonary function in ovine acute lung injury resulting from smoke inhalation and sepsis.
Topics: Airway Obstruction; Animals; Blood Pressure; Body Temperature; Disease Models, Animal; Female; Fibri | 2006 |
Regulation of fibrogenesis during the early phase of common bile duct obstruction.
Topics: Animals; Cell Proliferation; Cholestasis; Collagen; Common Bile Duct Diseases; Dinoprostone; Disease | 2006 |
Atorvastatin prevented and reversed dexamethasone-induced hypertension in the rat.
Topics: Analysis of Variance; Animals; Atorvastatin; Biomarkers; Blood Pressure; Body Weight; Dexamethasone; | 2006 |
Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality.
Topics: Animals; Bronchoalveolar Lavage Fluid; Caspases; Cyclosporine; Disease Models, Animal; Immunosuppres | 2006 |
Blockade of endothelin ET(A)/ET(B) receptors favors a role for endothelin during acute Trypanosoma cruzi infection in rats.
Topics: Animal Structures; Animals; Bosentan; Chagas Disease; Chemokines; Cytokines; Diaphragm; Disease Mode | 2006 |
Increased extravasation of macromolecules in skeletal muscles of the Zucker rat model.
Topics: Albumins; Animals; Blood Glucose; Body Weight; Capillary Permeability; Disease Models, Animal; Evans | 2006 |
Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus.
Topics: Acetylcarnitine; Adenosine Triphosphate; Animals; Carnitine; Disease Models, Animal; Energy Metaboli | 2006 |
Neuroprotective effect of the peptides ADNF-9 and NAP on hypoxic-ischemic brain injury in neonatal rats.
Topics: Aging; Animals; Animals, Newborn; Apoptosis; Asphyxia Neonatorum; Brain; Brain Infarction; Cerebral | 2006 |
Effect of a nitric oxide releasing derivative of paracetamol in a rat model of endotoxaemia.
Topics: Acetaminophen; Acetylcholine; Animals; Aspartate Aminotransferases; Blood Pressure; Creatinine; Cycl | 2006 |
Pravastatin reverses the down-regulating effect of inflammation on beta-adrenergic receptors: a disease-drug interaction between inflammation, pravastatin, and propranolol.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Biological Availability; C-Reactive | 2007 |
The effect of substance P on nitric oxide release in a rheumatoid arthritis model.
Topics: Aged; Animals; Arthritis, Rheumatoid; Cells, Cultured; Disease Models, Animal; Female; Gene Expressi | 2006 |
Beneficial effects of docosahexaenoic acid on active avoidance performance in 1K-1C hypertensive rats.
Topics: Animals; Avoidance Learning; Blood Pressure; Dietary Supplements; Disease Models, Animal; Docosahexa | 2007 |
Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Cognition Disorders; Colchicine; Cyclooxygen | 2006 |
Effects of severe smoke inhalation injury and septic shock on global hemodynamics and microvascular blood flow in sheep.
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Heart Rate; Lung; Microcirculation; Multipl | 2006 |
Systemic and regional hemodynamics in pigs with acute liver failure and the effect of albumin dialysis.
Topics: Albumins; Algorithms; Analysis of Variance; Animals; Blood Pressure; Catecholamines; Creatinine; Dis | 2006 |
Flurbiprofen and its nitric oxide-releasing derivative protect against septic shock in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cecum; Disease Models, Animal; Flu | 2006 |
Effect of sex hormones on non-esterified fatty acids, intra-abdominal fat accumulation, and hypertension induced by sucrose diet in male rats.
Topics: Animals; Blood Glucose; Blood Pressure; Body Weight; Dietary Sucrose; Disease Models, Animal; Estrad | 2006 |
Protective effects of atorvastatin in rat models of acute pulmonary embolism: involvement of matrix metalloproteinase-9.
Topics: Acute Disease; Analysis of Variance; Animals; Atorvastatin; Disease Models, Animal; Drug Evaluation, | 2007 |
Nitrite in action: a commentary on "Low-dose intravenous nitrite improves hemodynamics in a canine model of acute pulmonary thromboembolism".
Topics: Acute Disease; Animals; Blood Circulation; Disease Models, Animal; Dogs; Dose-Response Relationship, | 2006 |
Low-dose intravenous nitrite improves hemodynamics in a canine model of acute pulmonary thromboembolism.
Topics: Acute Disease; Animals; Blood Circulation; Blood Pressure; Cardiac Output; Cardiac Output, Low; Cons | 2006 |
Nitric oxide modulates glutathione synthesis during endotoxemia.
Topics: Animals; Body Weight; Catalase; Cysteine; Disease Models, Animal; Eating; Endotoxemia; Glutamate-Cys | 2006 |
Limited role of inducible nitric oxide synthase in blood-brain barrier function after experimental subarachnoid hemorrhage.
Topics: Animals; Benzenesulfonates; Blood-Brain Barrier; Brain Edema; Disease Models, Animal; Male; Nitrates | 2006 |
Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase.
Topics: Animals; Disease Models, Animal; Kidney; Male; Nitrates; Nitric Oxide Synthase Type I; Nitric Oxide | 2007 |
Nitric oxide promotes the progression of periapical lesion via inducing macrophage and osteoblast apoptosis.
Topics: Animals; Apoptosis; Cell Line; Cells, Cultured; Disease Models, Animal; Disease Progression; Drug Sy | 2007 |
Synergistic therapeutic potential of dexamethasone and L-arginine in lipopolysaccharide-induced septic shock.
Topics: Alanine Transaminase; Animals; Arginase; Arginine; Aspartate Aminotransferases; Cytokines; Dexametha | 2007 |
Sex differences in modulating blood brain barrier permeability by NO in pentylenetetrazol-induced epileptic seizures.
Topics: Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Convulsants; Disease Models, Animal; Dr | 2007 |
Carnitine deficiency provokes cisplatin-induced hepatotoxicity in rats.
Topics: Adenosine Triphosphate; Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti | 2007 |
Chronic administration of galanin attenuates the TNBS-induced colitis in rats.
Topics: Animals; Blotting, Western; Colitis; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relatio | 2007 |
Role of oxidative stress in celecoxib-induced renal damage in wistar rats.
Topics: Animals; Biomarkers; Cardiovascular Diseases; Catalase; Celecoxib; Creatinine; Cyclooxygenase Inhibi | 2007 |
Dihydrolipoic acid inhibits skin tumor promotion through anti-inflammation and anti-oxidation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cyclooxygenase 2; Dinoprostone; Disease Models, Ani | 2007 |
Methanol extract of Sorbus commixta cortex prevents vascular inflammation in rats with a high fructose-induced metabolic syndrome.
Topics: Animals; Aorta, Thoracic; Cell Adhesion Molecules; Cyclic GMP; Disease Models, Animal; Endothelin-1; | 2007 |
Inhaled ethyl nitrite prevents hyperoxia-impaired postnatal alveolar development in newborn rats.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Bronchodilator Agents; Bronchopulmonary Dyspl | 2007 |
In which period of injury is resveratrol treatment effective: ischemia or reperfusion?
Topics: Analysis of Variance; Animals; Antioxidants; Apoptosis; Disease Models, Animal; Enzyme Inhibitors; H | 2007 |
Effects of hypercapnia on BP in hypoalbuminemic and Nagase analbuminemic rats.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Blood Pressure; Buffers; Carbon Dioxide; Disease Models, A | 2007 |
Ceftazidime improves hemodynamics and oxygenation in ovine smoke inhalation injury and septic shock.
Topics: Animals; Anti-Bacterial Agents; Blood Pressure; Ceftazidime; Disease Models, Animal; Female; Heart R | 2007 |
High-density lipoprotein prevents organ damage in endotoxemia.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Blood Pressure; Bl | 2007 |
Endotoxemia produces coma and brain swelling in bile duct ligated rats.
Topics: Ammonia; Animals; Brain; Brain Edema; Capillaries; Cholestasis, Extrahepatic; Coma; Consciousness; C | 2007 |
Delayed 24 hours Nomega-nitro-L-arginine methyl ester injection induces pharmacological cardioprotection against reperfusion injury.
Topics: Adenosine; Animals; Arginine; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Enzyme Inh | 2007 |
The green tea polyphenol epigallocatechin-3-gallate improves systemic hemodynamics and survival in rodent models of polymicrobial sepsis.
Topics: Animals; Blood Pressure; Catechin; Disease Models, Animal; Gene Expression; Lung; Male; Mice; Mice, | 2007 |
Pyrrolidine dithiocarbamate reduces lung injury caused by mesenteric ischemia/reperfusion in a rat model.
Topics: Animals; Antioxidants; Capillary Permeability; Disease Models, Animal; Glutathione; Lung; Malondiald | 2007 |
Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Dinoprostone; Disease Mod | 2007 |
Simvastatin for rats with thioacetamide-induced liver failure and encephalopathy.
Topics: Alanine Transaminase; Ammonia; Animals; Aspartate Aminotransferases; Bilirubin; Disease Models, Anim | 2008 |
Modeling the monosomy for the telomeric part of human chromosome 21 reveals haploinsufficient genes modulating the inflammatory and airway responses.
Topics: Airway Resistance; Animals; Bronchoalveolar Lavage Fluid; Chromosome Disorders; Chromosomes, Human, | 2007 |
Neuroprotective effect of nimesulide, a preferential COX-2 inhibitor, against pentylenetetrazol (PTZ)-induced chemical kindling and associated biochemical parameters in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Cyclooxygenase Inhibitors; Disease | 2007 |
Nitrite does not provide additional protection to thrombolysis in a rat model of stroke with delayed reperfusion.
Topics: Animals; Disease Models, Animal; Magnetic Resonance Imaging; Male; Nitrites; Rats; Rats, Sprague-Daw | 2008 |
Acute systemic inflammation induces central mitochondrial damage and mnesic deficit in adult Swiss mice.
Topics: Animals; Behavior, Animal; Cognition Disorders; Cyclooxygenase 2; Disease Models, Animal; Glutathion | 2007 |
A moderately high fat diet promotes salt-sensitive hypertension in obese zucker rats by impairing nitric oxide production.
Topics: Animals; Body Weight; Diet; Dietary Fats; Disease Models, Animal; Feedback, Physiological; Female; H | 2007 |
Melatonin alleviates lung damage induced by the chemical warfare agent nitrogen mustard.
Topics: Animals; Antioxidants; Biomarkers; Chemical Warfare Agents; Disease Models, Animal; Dose-Response Re | 2007 |
Enteral resveratrol supplementation attenuates intestinal epithelial inducible nitric oxide synthase activity and mucosal damage in experimental necrotizing enterocolitis.
Topics: Administration, Oral; Animals; Animals, Newborn; Antioxidants; Disease Models, Animal; Drug Evaluati | 2007 |
Preventive effect of nebivolol on contrast-induced nephropathy in rats.
Topics: Adrenergic beta-Antagonists; Animals; Benzopyrans; Contrast Media; Creatinine; Disease Models, Anima | 2008 |
Corneal protein nitration in experimental uveitis.
Topics: Animals; Disease Models, Animal; Eye Proteins; Immunohistochemistry; Male; Neutrophils; Nitrates; Ni | 2007 |
Kynurenic acid inhibits intestinal hypermotility and xanthine oxidase activity during experimental colon obstruction in dogs.
Topics: Animals; Colonic Pseudo-Obstruction; Disease Models, Animal; Dogs; Gastrointestinal Motility; Hemody | 2008 |
Investigation of neuroprotective effect of dexamethasone by using nitric oxide and leukocyte levels in experimental head trauma.
Topics: Animals; Craniocerebral Trauma; Dexamethasone; Disease Models, Animal; Leukocytes; Male; Neuroprotec | 2007 |
The effects of arginine and selective inducible nitric oxide synthase inhibitor on pathophysiology of sepsis in a CLP model.
Topics: Animals; Arginine; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Guanidines; | 2008 |
Genetical analbuminemia is not an appropriate model for hypoalbuminemia in critically ill patients.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Blood Pressure; Buffers; Carbon Dioxide; Disease Models, A | 2007 |
Effects of hypercapnea on BP in rats.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Blood Pressure; Buffers; Carbon Dioxide; Disease Models, A | 2007 |
Influence of soluble guanylate cyclase inhibition on inflammation and motility disturbances in DSS-induced colitis.
Topics: Animals; Colitis; Cyclic GMP; Dextran Sulfate; Disease Models, Animal; Enzyme Inhibitors; Guanylate | 2008 |
Tetradecylthioacetic acid prevents the inflammatory response in two-kidney, one-clip hypertension.
Topics: Animals; Body Weight; Chemokine CCL2; Dinoprost; Disease Models, Animal; Eating; Free Radical Scaven | 2008 |
The effect of lipoic acid on antioxidant status and lipid peroxidation in rats exposed to chronic restraint stress.
Topics: Animals; Antioxidants; Brain; Catalase; Disease Models, Animal; Glutathione Peroxidase; Lipid Peroxi | 2008 |
Nailing the evidence.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Anions; Blood Pressure; Buffers; Carbon Dioxide; Disease M | 2007 |
How DMSO, a widely used solvent, affects spinal cord injury.
Topics: Animals; Aorta, Abdominal; Dimethyl Sulfoxide; Disease Models, Animal; Free Radical Scavengers; Liga | 2008 |
Pharmacological induction of heme oxygenase-1 inhibits iNOS and oxidative stress in renal ischemia-reperfusion injury.
Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Enzyme Induction; Heme Oxygenase-1; Isoe | 2007 |
CSC, an adenosine A(2A) receptor antagonist and MAO B inhibitor, reverses behavior, monoamine neurotransmission, and amino acid alterations in the 6-OHDA-lesioned rats.
Topics: Adenosine A2 Receptor Agonists; Animals; Behavior, Animal; Biogenic Monoamines; Caffeine; Disease Mo | 2008 |
Human umbilical cord blood-derived CD34+ cells can be used as a prophylactic agent for experimental heatstroke.
Topics: Animals; Antigens, CD34; Basal Ganglia; Cerebrovascular Disorders; Cord Blood Stem Cell Transplantat | 2008 |
Cytoprotective role of nitric oxide associated with Hsp70 expression in neonatal obstructive nephropathy.
Topics: Animals; Animals, Newborn; Apoptosis; Arginine; bcl-2-Associated X Protein; Body Weight; Caspase 3; | 2008 |
Angiopoietin-1 prevents hypertension and target organ damage through its interaction with endothelial Tie2 receptor.
Topics: Angiopoietin-1; Animals; Antihypertensive Agents; Blood Pressure; Capillaries; Disease Models, Anima | 2008 |
Effect of some natural products either alone or in combination on gastritis induced in experimental rats.
Topics: Administration, Oral; Analysis of Variance; Animals; Curcuma; Disease Models, Animal; Fatty Acids, O | 2008 |
Beneficial effects of low doses of red wine consumption on perturbed shear stress-induced atherogenesis.
Topics: Administration, Oral; Animals; Antioxidants; Atherosclerosis; Cells, Cultured; Disease Models, Anima | 2008 |
Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus.
Topics: Animals; Aorta; Biopterins; Carotid Arteries; Cholesterol; Diabetes Mellitus, Experimental; Disease | 2008 |
p38 MAPK-dependent eNOS upregulation is critical for 17beta-estradiol-mediated cardioprotection following trauma-hemorrhage.
Topics: Abdomen; Animals; Calmodulin; Cardiotonic Agents; Caveolin 1; Chemokine CXCL1; Chemokine CXCL2; Dise | 2008 |
Effects of activated protein C on neonatal hypoxic ischemic brain injury.
Topics: Animals; Animals, Newborn; Anticoagulants; Apoptosis; Brain; Carotid Stenosis; Dentate Gyrus; Diseas | 2008 |
Opioid receptor blockade improves mesenteric responsiveness in biliary cirrhosis.
Topics: Animals; Disease Models, Animal; Ligation; Liver Cirrhosis, Biliary; Male; Mesentery; Naltrexone; Na | 2008 |
Red cell glutathione deficiency: clinical and biochemical investigations using sheep as an experimental model system.
Topics: Anemia; Animals; Cysteine; Disease Models, Animal; Erythrocyte Aging; Erythrocytes; Glutamate-Cystei | 1981 |
Depression of murine natural killer cell cytotoxicity by isobutyl nitrite.
Topics: Acquired Immunodeficiency Syndrome; Animals; Cytotoxicity, Immunologic; Disease Models, Animal; Fema | 1984 |
Nitrate and human cancer: a review of the evidence.
Topics: Animals; Chile; Colombia; Diet; Disease Models, Animal; England; Fertilizers; Humans; Neoplasms; Nit | 1980 |
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.
Topics: Animals; Base Sequence; Disease Models, Animal; Drug Resistance; Immunoblotting; Interferon-gamma; L | 1995 |
Induction of nitric oxide synthase and concomitant suppression of superoxide dismutases in experimental colitis in rats.
Topics: Animals; Blotting, Northern; Colitis; Colon; Disease Models, Animal; Enzyme Induction; Female; Gene | 1995 |
N-Acetylserotonin prevents the hypotension induced by bacterial lipopolysaccharides in the rat.
Topics: Amino Acid Oxidoreductases; Animals; Blood Pressure; Disease Models, Animal; Hypotension; Lipopolysa | 1993 |
Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cholic Acids; Dinoprostone; Disease Models, Animal; H | 1994 |
N-monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Arthritis, Experimental; Disease Models, Animal; Male | 1994 |
Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis.
Topics: Amino Acid Sequence; Animals; Base Sequence; Disease Models, Animal; Enzyme Induction; Female; Gene | 1995 |
Polydeoxyribonucleotides and nitric oxide release from guinea-pig hearts during ischaemia and reperfusion.
Topics: Acetylcholine; Animals; Arginine; Arrhythmias, Cardiac; Chemical Fractionation; Coronary Circulation | 1995 |
The pressor effect of recombinant human erythropoietin is not due to decreased activity of the endogenous nitric oxide system.
Topics: Animals; Blood Pressure; Disease Models, Animal; Erythropoietin; Hematocrit; Hydrogen-Ion Concentrat | 1995 |
Spontaneous intestinal inflammation and nitric oxide metabolism in HLA-B27 transgenic rats.
Topics: Animals; Animals, Genetically Modified; Colitis; Colon; Disease Models, Animal; Edetic Acid; Gastric | 1995 |
Modulation of granuloma formation by endogenous nitric oxide.
Topics: Animals; Arginine; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Impla | 1994 |
Nitric oxide inhibition normalizes splenocyte interleukin-10 synthesis in murine thermal injury.
Topics: Alcoholism; Animals; Arginine; Burns; Dinoprostone; Disease Models, Animal; Dose-Response Relationsh | 1994 |
Nitric oxide release in response to gut injury.
Topics: Animals; Bile Acids and Salts; Capillary Permeability; Chromium Radioisotopes; Disease Models, Anima | 1993 |
The involvement of nitric oxide in a mouse model of adult respiratory distress syndrome.
Topics: Animals; Biomarkers; Bronchoalveolar Lavage Fluid; Cytokines; Dipeptides; Disease Models, Animal; Fe | 1995 |
Efficacy of treatment with the iron (III) complex of diethylenetriamine pentaacetic acid in mice and primates inoculated with live lethal dose 100 Escherichia coli.
Topics: Animals; Disease Models, Animal; Escherichia coli; Escherichia coli Infections; Free Radical Scaveng | 1996 |
Effect of liposome-encapsulation on immunomodulating and antiviral activities of interferon-gamma 1.
Topics: Animals; Antiviral Agents; Cells, Cultured; Disease Models, Animal; Female; Humans; Influenza A viru | 1996 |
Effect of the bradykinin B2 receptor antagonist Hoe140 in experimental pneumococcal meningitis in the rat.
Topics: Animals; Anti-Infective Agents; Body Water; Bradykinin; Bradykinin Receptor Antagonists; Brain; Dise | 1996 |
Pteridine and nitrite/nitrate formation in experimental septic and traumatic shock.
Topics: Animals; Arteries; Cardiac Output; Creatinine; Disease Models, Animal; Escherichia coli Infections; | 1996 |
Nitric oxide in brain death related cardiovascular dysfunction.
Topics: Animals; Arginine; Brain Death; Disease Models, Animal; Dogs; Fourier Analysis; Hemodynamics; Male; | 1996 |
Acute protein-calorie malnutrition impairs wound healing: a possible role of decreased wound nitric oxide synthesis.
Topics: Acute Disease; Amino Acids; Animals; Cells, Cultured; Collagen; Disease Models, Animal; DNA; Hydroxy | 1997 |
Nitric oxide synthase inhibitor influences prostaglandin and interleukin-1 production in experimental arthritic joints.
Topics: Animals; Arthritis, Experimental; Capillary Permeability; Chemotaxis, Leukocyte; Dinoprostone; Disea | 1997 |
Effects of aminoguanidine on systemic inflammatory response syndrome induced by platelet activating factor and by lipopolysaccharide in rats.
Topics: Animals; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Guanidines; Injections, Intrav | 1997 |
Protective effects of IL-4, IL-10, IL-12, and IL-13 in IgG immune complex-induced lung injury: role of endogenous IL-12.
Topics: Animals; Antigen-Antibody Complex; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Immunoglobu | 1997 |
Inhibition of inducible nitric oxide synthase expression and stimulation of the endothelial formation of nitric oxide most likely accounts for the protective effect of 2-(allylthio)pyrazine in a murine model of endotoxemia.
Topics: Animals; Cyclic GMP; Disease Models, Animal; Endothelium, Vascular; Endotoxemia; Enzyme Inhibitors; | 1997 |
Changes in vascular porosity and joint blood flow during development of collagen induced arthritis in the rat. Modulation by indomethacin and L-NAME.
Topics: Animals; Arthritis; Capillary Permeability; Collagen; Disease Models, Animal; Female; Hindlimb; Indo | 1997 |
Glucocorticoid regulation of nitric oxide and tetrahydrobiopterin in a rat model of endotoxic shock.
Topics: Adrenalectomy; Animals; Biopterins; Dexamethasone; Disease Models, Animal; Enzyme Induction; Escheri | 1997 |
Role of nitric oxide in experimental obliterative bronchiolitis (chronic rejection) in the rat.
Topics: Animals; Bronchiolitis Obliterans; Cell Division; Cytokines; Disease Models, Animal; Graft Rejection | 1997 |
Effect of exercise training and food restriction on endothelium-dependent relaxation in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous NIDDM.
Topics: Abdomen; Adipose Tissue; Animals; Blood Glucose; Body Composition; Body Weight; Cholesterol; Diabete | 1998 |
Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation.
Topics: Animals; Carrageenan; Disease Models, Animal; Edema; Enzyme Inhibitors; Free Radical Scavengers; Gua | 1998 |
Intracolonic release of nitric oxide during trinitrobenzene sulfonic acid rat colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Leukotriene B4; Male; Nitric Oxide; Nitric Oxide Sy | 1997 |
Regulatory interactions between inducible nitric oxide synthase and eicosanoids in glomerular immune injury.
Topics: Animals; Base Sequence; Basement Membrane; Cyclooxygenase Inhibitors; Disease Models, Animal; DNA Pr | 1998 |
Protective effects of Mu-Fang-Ji-Tang against myocardial injury in a murine model of congestive heart failure induced by viral myocarditis.
Topics: Animals; Body Weight; Cell Line; Disease Models, Animal; Drugs, Chinese Herbal; Heart Failure; Macro | 1998 |
Experimental focal segmental glomerulosclerosis in mice.
Topics: Animals; Antibiotics, Antineoplastic; Cholesterol; Disease Models, Animal; Disease Progression; Doxo | 1998 |
Role of endothelin and nitric oxide imbalance in the pathogenesis of hypoxia-induced arterial hypertension.
Topics: Acetamides; Animals; Arginine; Blood Pressure; Disease Models, Animal; Endothelin Receptor Antagonis | 1998 |
Protective effect of ciliary neurotrophic factor (CNTF) in a model of endotoxic shock: action mechanisms and role of CNTF receptor alpha.
Topics: Adrenalectomy; Animals; Ciliary Neurotrophic Factor; Disease Models, Animal; Humans; Lipopolysacchar | 1998 |
Klotho protein protects against endothelial dysfunction.
Topics: Acetylcholine; Aging; Animals; Arteriosclerosis; Cardiovascular System; Disease Models, Animal; Endo | 1998 |
Evaluation of the magnitude and rate of nitric oxide production from nitrite in biological systems.
Topics: Animals; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Kinetics; Luminescent Measure | 1998 |
Collagen induced arthritis: reversal by mercaptoethylguanidine, a novel antiinflammatory agent with a combined mechanism of action.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Collagen; Collagenases; Disease Models, Animal; Enzyme | 1998 |
Inducible nitric oxide synthase expression is reduced in cystic fibrosis murine and human airway epithelial cells.
Topics: Amiloride; Animals; Biological Transport; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance | 1998 |
Aerosolized soluble nitric oxide donor improves oxygenation and pulmonary hypertension in acute lung injury.
Topics: Administration, Inhalation; Aerosols; Amino Acids, Diamino; Animals; Cardiac Catheterization; Cardia | 1998 |
Influence of L-arginine, aminoguanidine, and NG-nitro-L-arginine methyl ester (L-name) on the survival rate in a rat model of hemorrhagic shock.
Topics: Animals; Arginine; Aspartate Aminotransferases; Blood Pressure; Creatinine; Dinoprostone; Disease Mo | 1999 |
Insulitis and mechanisms of disease resistance: studies in an animal model of insulin dependent diabetes mellitus.
Topics: Age of Onset; Animals; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Type 1; Disease Models, An | 1999 |
Anti-inflammatory effects of a new tumour necrosis factor-alpha (TNF-alpha) inhibitor (CNI-1493) in collagen-induced arthritis (CIA) in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Arthritis, Experimental; Collagen; Dis | 1999 |
Oral spermine administration inhibits nitric oxide-mediated intestinal damage and levels of systemic inflammatory mediators in a mouse endotoxin model.
Topics: Administration, Oral; Animals; Disease Models, Animal; Escherichia coli; Female; Immunohistochemistr | 1999 |
Porcine endotoxemic shock is associated with increased expired nitric oxide.
Topics: Analysis of Variance; Animals; Arginine; Base Sequence; Blotting, Western; Breath Tests; Disease Mod | 1999 |
Role of inducible nitric oxide synthase in leukocyte extravasation in vivo.
Topics: Acute Disease; Animals; Ascitic Fluid; Blotting, Western; Cell Movement; Disease Models, Animal; Enz | 1999 |
Pentoxifylline improves circulatory failure and survival in murine models of endotoxaemia.
Topics: Anesthesia; Animals; Aorta, Thoracic; Blood Circulation; Blood Pressure; Cardiovascular Diseases; Di | 1999 |
Effects of cyanosis and hypothermic circulatory arrest on lung function in neonatal lambs.
Topics: Animals; Animals, Newborn; Cardiac Output; Cardiopulmonary Bypass; Chronic Disease; Cyanosis; Cyclic | 1999 |
Inhaled nitric oxide improves hemodynamics during a venous air infusion (VAI) in dogs.
Topics: Administration, Inhalation; Animals; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Emb | 1999 |
Two patterns of lipid deposition in the cholesterol-fed rabbit.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Celiac Artery; Cholesterol, Dietary; Disease Models, Ani | 1999 |
Effect of cortisol-synthesis inhibition on endotoxin-induced porcine acute lung injury, shock, and nitric oxide production.
Topics: Acid-Base Imbalance; Animals; Blood Gas Analysis; Bronchoalveolar Lavage Fluid; Disease Models, Anim | 1999 |
N-Acetyl-cysteine inhibition of encephalomyelitis Theiler's virus-induced nitric oxide and tumour necrosis factor-alpha production by murine astrocyte cultures.
Topics: Acetylcysteine; Animals; Animals, Newborn; Astrocytes; Cardiovirus Infections; Cells, Cultured; Cere | 1999 |
Nuclear factor-kappaB activation mediates inducible nitric oxide synthase expression in carrageenin-induced rat pleurisy.
Topics: Animals; Antioxidants; Carrageenan; Cell Movement; Cell Nucleus; Disease Models, Animal; DNA; Dose-R | 1999 |
Specific inhibitors of inducible nitric oxide synthase: efficacy in a rodent model of sepsis.
Topics: Animals; Cell Line; Disease Models, Animal; Enzyme Inhibitors; Humans; Lipopolysaccharides; Mice; Ni | 1999 |
Innate lung defenses and compromised Pseudomonas aeruginosa clearance in the malnourished mouse model of respiratory infections in cystic fibrosis.
Topics: Administration, Inhalation; Animals; Chemokine CXCL2; Chemotactic Factors; Cystic Fibrosis; Cystic F | 2000 |
Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion.
Topics: Animals; Blood Pressure; Catalysis; Celiac Artery; Disease Models, Animal; Endothelium, Vascular; Fe | 2000 |
Pulmonary blast injury increases nitric oxide production, disturbs arginine metabolism, and alters the plasma free amino acid pool in rabbits during the early posttraumatic period.
Topics: Amino Acids; Animals; Arginine; Blast Injuries; Disease Models, Animal; Male; Nitrates; Nitric Oxide | 2000 |
Differential regulation of nitric oxide synthase isoforms in experimental acute chagasic cardiomyopathy.
Topics: Acute Disease; Animals; Chagas Cardiomyopathy; Disease Models, Animal; Isoenzymes; Male; Malondialde | 2000 |
Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Choline O-Acetyl | 2000 |
The effects of NO synthase inhibitors on murine collagen-induced arthritis do not support a role of NO in the protective effect of IFN-gamma.
Topics: Administration, Oral; Animals; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Collagen; | 2000 |
Mechanisms of vascular instability in a transgenic mouse model of sickle cell disease.
Topics: Anemia, Sickle Cell; Animals; Aorta; Autoantibodies; Blood Pressure; Calcimycin; Cyclic GMP; Disease | 2000 |
Prolonged hypercapnia-evoked cerebral hyperemia via K(+) channel- and prostaglandin E(2)-dependent endothelial nitric oxide synthase induction.
Topics: Acidosis; Animals; Calcium Signaling; Carbon Dioxide; Dinoprostone; Disease Models, Animal; Dose-Res | 2000 |
Hyperhomocysteinemia impairs angiogenesis in response to hindlimb ischemia.
Topics: Angiography; Animals; Arginine; Blood Pressure; Body Weight; Collateral Circulation; Cyclic GMP; Dis | 2000 |
Association of renal injury with increased oxygen free radical activity and altered nitric oxide metabolism in chronic experimental hemosiderosis.
Topics: Animals; Chronic Disease; Disease Models, Animal; Free Radicals; Hemosiderosis; Humans; Iron; Kidney | 2000 |
Evaluation of low-dose endotoxin administration during pregnancy as a model of preeclampsia.
Topics: Animals; Blood Pressure; Blood Pressure Determination; Disease Models, Animal; Dose-Response Relatio | 2000 |
Effects of MK-801, dantrolene, and FK506 on convulsive seizures and brain nitric oxide production in seizure-susceptible EL mice.
Topics: Animals; Brain; Brain Chemistry; Calcineurin; Calcium; Dantrolene; Disease Models, Animal; Dizocilpi | 2001 |
The phosphodiesterase inhibitors pentoxifylline and rolipram suppress macrophage activation and nitric oxide production in vitro and in vivo.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Autoimmune Diseases; Bucladesine; Cells, Cultured; | 2001 |
Endothelial dysfunction and xanthine oxidoreductase activity in rats with human renin and angiotensinogen genes.
Topics: Acetylcholine; Angiotensin II; Angiotensinogen; Animals; Animals, Genetically Modified; Antihyperten | 2001 |
Inhibition of inducible nitric oxide synthase limits nitric oxide production and experimental aneurysm expansion.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Disease Progression; | 2001 |
Erythrocyte deformability is a nitric oxide-mediated factor in decreased capillary density during sepsis.
Topics: Acute Disease; Animals; Blood Flow Velocity; Blood Pressure; Disease Models, Animal; Electron Spin R | 2001 |
Cardiac functional and structural alterations induced by endotoxin in rats: importance of platelet-activating factor.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Echocardiography; Electrocardiography | 2001 |
Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase.
Topics: Animals; Arteries; Blood Flow Velocity; Blood Glucose; Body Weight; Disease Models, Animal; Glucose; | 2001 |
Pravastatin reduces myocardial lesions induced by acute inhibition of nitric oxide biosynthesis in normocholesterolemic rats.
Topics: Analysis of Variance; Animals; Anticholesteremic Agents; Cardiomyopathies; Disease Models, Animal; E | 2001 |
The role of the interaction between endogenous opioids and nitric oxide in the pathophysiology of ethanol-induced gastric damage in cholestatic rats.
Topics: Alcohol Deterrents; Animals; Arginine; Bile Ducts; Cholestasis; Disease Models, Animal; Enzyme Inhib | 2001 |
N-acetyl-L-cysteine improves renal medullary hypoperfusion in acute renal failure.
Topics: Acetylcysteine; Acute Kidney Injury; Animals; Blood Flow Velocity; Disease Models, Animal; Enzyme In | 2001 |
Angiotensin-converting enzyme inhibitor preserves p21 and endothelial nitric oxide synthase expression in monocrotaline-induced pulmonary arterial hypertension in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Cells, Cultured; Cyclin-Dependent | 2001 |
Inhibition of nitric oxide synthesis by L-name exacerbates acute lung injury induced by hepatic ischemia-reperfusion.
Topics: Alanine Transaminase; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enzyme Inhibito | 2001 |
Antiinflammatory and antiarteriosclerotic actions of HMG-CoA reductase inhibitors in a rat model of chronic inhibition of nitric oxide synthesis.
Topics: Animals; Anti-Inflammatory Agents; Arteriosclerosis; Blood Pressure; Chemokine CCL2; Coronary Vessel | 2001 |
Role of nitric oxide in acidosis-induced intestinal injury in anesthetized rats.
Topics: Acidosis; Anesthesia; Animals; Blood Pressure; Carbon Dioxide; Disease Models, Animal; Hemodynamics; | 2001 |
Presence of nitrotyrosine with minimal inducible nitric oxide synthase induction in lipopolysaccharide-treated pigs.
Topics: Animals; Blood Gas Analysis; Blotting, Western; Disease Models, Animal; Hemodynamics; Lipopolysaccha | 2001 |
[Evidence of increased endogenous carbon monoxide production in asthma].
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Carbon Monoxide; Cell Line; Child; Child, Preschool; | 1999 |
Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosis.
Topics: Aging; Angioplasty, Balloon, Coronary; Animals; Aspirin; Coronary Restenosis; Coronary Vessels; Dise | 2002 |
Inhibition of nitric oxide synthase does not influence urinary nitrite plus nitrate excretion after renal ischemic injury.
Topics: Animals; Disease Models, Animal; Ischemia; Kidney; Kidney Tubules; Male; NG-Nitroarginine Methyl Est | 2002 |
Streptozotocin-pancreatic damage in the rat: modulatory effect of 15-deoxy delta12,14-prostaglandin j(2) on nitridergic and prostanoid pathway.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Islets of Langerhans; Nitr | 2002 |
[Expression of ET-1 mRNA in the lung of hepatopulmonary syndrome rats].
Topics: Animals; Disease Models, Animal; Endothelin-1; Hepatopulmonary Syndrome; Image Processing, Computer- | 2002 |
A synthetic isoquinoline alkaloid, 1-(beta-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (YS 51), reduces inducible nitric oxide synthase expression and improves survival in a rodent model of endotoxic shock.
Topics: Animals; Aorta; Cell Line; Disease Models, Animal; DNA; Drug Interactions; Fibrinolytic Agents; Gene | 2002 |
Dual effect of local application of nitric oxide donors in a model of incision pain in rats.
Topics: Animals; Disease Models, Animal; Diuretics, Osmotic; Dose-Response Relationship, Drug; Enzyme Inhibi | 2002 |
Differential function of nitric oxide in murine antigen-induced arthritis.
Topics: Acute Disease; Animals; Arthritis, Experimental; Cell Adhesion Molecules; Chronic Disease; Disease M | 2002 |
Chronic feeding of a nitric oxide synthase inhibitor induces postprandial hypertriglyceridemia in type 2 diabetic model rats, Otsuka Long-Evans Tokushima Fatty rats, but not in nondiabetic rats.
Topics: Animals; Arginine; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus; Diabetes Mellitus, | 2002 |
Inhibition of NOS II prevents cardiac dysfunction in myocardial infarction and congestive heart failure.
Topics: Animals; Blotting, Western; Coronary Vessels; Disease Models, Animal; Enzyme Inhibitors; Heart Failu | 2002 |
[Lack of a cancerogenic effect after application of amines and amides together with nitrite in rabbits (author's transl)].
Topics: Amides; Amines; Animals; Carcinogens; Disease Models, Animal; Neoplasms, Experimental; Nitrites; Rab | 1977 |
Neoplasia induced in male rats fed lead acetate, ethyl urea, and sodium nitrite.
Topics: Animals; Disease Models, Animal; Kidney Neoplasms; Lead; Male; Neoplasms, Experimental; Nitrites; Or | 1985 |
Evaluation of antihypertensive drugs in dogs with angiotensin-induced hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Disease Models, Animal; Dogs; Female; Hexamethoniu | 1971 |