nitrites has been researched along with Diabetic Retinopathy in 12 studies
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
Diabetic Retinopathy: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effect of ubiquinone and combined antioxidant therapy on mitochondrial function in non-proliferative diabetic retinopathy (NPDR) in a randomized, double-blind, phase IIa, placebo-controlled, clinical trial." | 9.22 | The antioxidant effect of ubiquinone and combined therapy on mitochondrial function in blood cells in non-proliferative diabetic retinopathy: A randomized, double-blind, phase IIa, placebo-controlled study. ( Castellanos-González, JA; Martínez-Romero, EC; Miller-Arrevillaga, G; Miranda-Díaz, AG; Pacheco-Moisés, FP; Rodríguez-Carrizalez, AD; Román-Pintos, LM, 2016) |
| "To evaluate the effect of ubiquinone and combined antioxidant therapy on mitochondrial function in non-proliferative diabetic retinopathy (NPDR) in a randomized, double-blind, phase IIa, placebo-controlled, clinical trial." | 5.22 | The antioxidant effect of ubiquinone and combined therapy on mitochondrial function in blood cells in non-proliferative diabetic retinopathy: A randomized, double-blind, phase IIa, placebo-controlled study. ( Castellanos-González, JA; Martínez-Romero, EC; Miller-Arrevillaga, G; Miranda-Díaz, AG; Pacheco-Moisés, FP; Rodríguez-Carrizalez, AD; Román-Pintos, LM, 2016) |
| "Changes in vascular endothelial growth factor (VEGF), angiotensin-converting enzyme (ACE), matrix metalloproteinase (MMP)-9, and endothelial nitric oxide synthase (eNOS) mRNA expression profiles and oxidative stress in the eye tissue microenviroment may have important roles in ocular neovascularization and permeability in proliferative diabetic retinopathy." | 3.78 | Investigation of ocular neovascularization-related genes and oxidative stress in diabetic rat eye tissues after resveratrol treatment. ( Alp, E; Aricioglu, A; Cumaoglu, A; Dogan, I; Ekmekci, A; Ergin, V; Menevse, A; Menevse, S; Yar, AS, 2012) |
| "Using high-pressure liquid chromatography citrulline, arginine and nitrite were measured in vitreous fluid of 93 eyes with RRD, nine eyes with a traction retinal detachment due to proliferative diabetic retinopathy (PDR), and in 49 control samples of vitreous fluid from eyes without retinal detachment." | 3.73 | Increased nitric oxide (NO) pathway metabolites in the vitreous fluid of patients with rhegmatogenous retinal detachment or diabetic traction retinal detachment. ( Deutz, NE; Diederen, RM; Hendrikse, F; Kessels, AG; La Heij, EC; van Eijk, HM, 2006) |
| "Ticlopidine, a thienopyridine that prevents the progression of diabetic retinopathy in humans, was recently shown to increase nitric oxide (NO) production in human neutrophils." | 3.72 | Effects of clopidogrel and ticlopidine on experimental diabetic ischemic retinopathy in rats. ( Arrebola, M; De La Cruz, P; de la Cuesta, FS; González-Correa, A; Martinez-Cerdán, E; Moreno, A, 2003) |
| "The treatment with losartan ameliorated all of the above alterations." | 1.36 | Reduction of inducible nitric oxide synthase via angiotensin receptor blocker prevents the oxidative retinal damage in diabetic hypertensive rats. ( de Faria, JB; de Faria, JM; Rosales, MA; Silva, KC, 2010) |
| "The 39 patients with type 2 diabetes included in this study were divided by stage of DR into 3 groups: group A, those without DR; group B, those with background/preproliferative DR; and group C, those with proliferative DR." | 1.32 | Basal serum nitric oxide levels in patients with type 2 diabetes mellitus and different stages of retinopathy. ( Biçer, N; Güner, G; Ozbay, D; Ozden, S; Tatlipinar, S; Yaylali, V; Yildirim, C, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (58.33) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mandal, LK | 1 |
| Choudhuri, S | 1 |
| Dutta, D | 1 |
| Mitra, B | 1 |
| Kundu, S | 1 |
| Chowdhury, IH | 1 |
| Sen, A | 1 |
| Chatterjee, M | 1 |
| Bhattacharya, B | 1 |
| Rodríguez-Carrizalez, AD | 1 |
| Castellanos-González, JA | 1 |
| Martínez-Romero, EC | 1 |
| Miller-Arrevillaga, G | 1 |
| Román-Pintos, LM | 1 |
| Pacheco-Moisés, FP | 1 |
| Miranda-Díaz, AG | 1 |
| Silva, KC | 1 |
| Rosales, MA | 1 |
| de Faria, JB | 1 |
| de Faria, JM | 1 |
| Yar, AS | 1 |
| Menevse, S | 1 |
| Dogan, I | 1 |
| Alp, E | 1 |
| Ergin, V | 1 |
| Cumaoglu, A | 1 |
| Aricioglu, A | 1 |
| Ekmekci, A | 1 |
| Menevse, A | 1 |
| De La Cruz, P | 2 |
| Arrebola, M | 1 |
| González-Correa, A | 1 |
| Martinez-Cerdán, E | 1 |
| Moreno, A | 2 |
| de la Cuesta, FS | 1 |
| Ozden, S | 1 |
| Tatlipinar, S | 1 |
| Biçer, N | 1 |
| Yaylali, V | 1 |
| Yildirim, C | 1 |
| Ozbay, D | 1 |
| Güner, G | 1 |
| Diederen, RM | 1 |
| La Heij, EC | 1 |
| Deutz, NE | 1 |
| Kessels, AG | 1 |
| van Eijk, HM | 1 |
| Hendrikse, F | 1 |
| Salceda, R | 1 |
| Hernández-Espinosa, C | 1 |
| Sánchez-Chávez, G | 1 |
| Mizobe, A | 1 |
| Murai, S | 1 |
| Mizushima, N | 1 |
| Oku, H | 1 |
| Kida, T | 1 |
| Sugiyama, T | 1 |
| Hamada, J | 1 |
| Sato, B | 1 |
| Ikeda, T | 1 |
| Guerrero, A | 1 |
| Paniego, J | 1 |
| Arranz, I | 1 |
| Sánchez De La Cuesta, F | 1 |
| Joussen, AM | 1 |
| Poulaki, V | 1 |
| Qin, W | 1 |
| Kirchhof, B | 1 |
| Mitsiades, N | 1 |
| Wiegand, SJ | 1 |
| Rudge, J | 1 |
| Yancopoulos, GD | 1 |
| Adamis, AP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Combined Antioxidant Therapy on the Levels of Oxidative Stress Markers in Aqueous and Vitreous Humor of Patients With Proliferative Diabetic Retinopathy[NCT04071977] | Phase 2 | 40 participants (Actual) | Interventional | 2020-03-25 | Completed | ||
| Effect of Prolonged Combined Antioxidant Therapy Intake on Oxidative Stress and Mitochondrial Dysfunction Markers in Patients With Diabetic Retinopathy[NCT03702374] | Phase 3 | 132 participants (Actual) | Interventional | 2018-09-26 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for nitrites and Diabetic Retinopathy
11 other studies available for nitrites and Diabetic Retinopathy
| Article | Year |
|---|---|
Oxidative stress-associated neuroretinal dysfunction and nitrosative stress in diabetic retinopathy.
Topics: Adult; Case-Control Studies; Diabetic Retinopathy; Female; Glutamic Acid; Humans; Leukocytes, Mononu | 2013 |
Reduction of inducible nitric oxide synthase via angiotensin receptor blocker prevents the oxidative retinal damage in diabetic hypertensive rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Animals; | 2010 |
Investigation of ocular neovascularization-related genes and oxidative stress in diabetic rat eye tissues after resveratrol treatment.
Topics: Angiotensin-Converting Enzyme 2; Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Eye | 2012 |
Effects of clopidogrel and ticlopidine on experimental diabetic ischemic retinopathy in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Oral; Animals; Clopidogrel; Diabetes Mellitus, Experim | 2003 |
Basal serum nitric oxide levels in patients with type 2 diabetes mellitus and different stages of retinopathy.
Topics: Adult; Aged; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Humans; | 2003 |
Increased nitric oxide (NO) pathway metabolites in the vitreous fluid of patients with rhegmatogenous retinal detachment or diabetic traction retinal detachment.
Topics: Aged; Arginine; Chromatography, High Pressure Liquid; Citrulline; Diabetic Retinopathy; Female; Huma | 2006 |
L-arginine uptake in normal and diabetic rat retina and retinal pigment epithelium.
Topics: Animals; Arginine; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Nitrates; Nitric Oxide; Ni | 2008 |
Fluorescein studies of hypertensive retinopathy.
Topics: Adult; Animals; Arteriosclerosis; Blood Flow Velocity; Blood Pressure; Diabetic Retinopathy; Exudate | 1967 |
Possible involvement of endothelin-1 and nitric oxide in the pathogenesis of proliferative diabetic retinopathy.
Topics: Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Diabetic Retinopathy; Endothel | 2001 |
Effect of aspirin on prostanoids and nitric oxide production in streptozotocin-diabetic rats with ischemic retinopathy.
Topics: Administration, Oral; Animals; Aorta; Aspirin; Diabetes Mellitus, Experimental; Diabetic Retinopathy | 2002 |
Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo.
Topics: Animals; Cell Adhesion; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endothelial Growth Fa | 2002 |