Page last updated: 2024-10-19

nitrites and Diabetes Mellitus, Type 2

nitrites has been researched along with Diabetes Mellitus, Type 2 in 92 studies

Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)

Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.

Research Excerpts

ExcerptRelevanceReference
"In this study we assessed the content of nitrites III and V in selected herbal medicaments used in obesity and diabetes mellitus type 2 treatment."3.73[Nitrite and nitrate content in selected herbal medicaments used in obesity and diabetes mellitus type 2 treatment]. ( Szydłowska, E; Szydłowski, W; Zareba, S, 2005)
"Patients with type 2 diabetes mellitus (T2DM) have increased cardiovascular risk due to elevated blood pressure (BP)."3.11Dietary Inorganic Nitrate/Nitrite Supplementation Reduces Central and Peripheral Blood Pressure in Patients With Type 2 Diabetes Mellitus. ( Bock, JM; Casey, DP; Feider, AJ; Hanada, S; Hughes, WE; Ueda, K, 2022)
" However, it is not known whether low NO bioavailability and oxidative stress affect the responsiveness of ED patients to sildenafil."2.78Low nitric oxide bioavailability is associated with better responses to sildenafil in patients with erectile dysfunction. ( Jordão, AA; Lacchini, R; Martins, AC; Muniz, JJ; Nobre, YT; Sertório, JT; Tanus-Santos, JE; Tucci, S, 2013)
"Obesity, type 2 diabetes and the metabolic syndrome are associated with a decrease in NO bioavailability."2.53Dietary inorganic nitrate: From villain to hero in metabolic disease? ( Griffin, JL; McNally, B; Roberts, LD, 2016)
"IDDM is characterized by progressive beta-cell destruction which leads to complete insulin deficiency; at the time of diagnosis 80-90% of beta cells have been destroyed."2.39Dietary factors in the aetiology of diabetes. ( Aro, A; Virtanen, SM, 1994)
"Sixty-six persons with type 2 diabetes were divided into HIIT, MICT, and control groups."1.72Improved blood pressure and flow-mediated dilatation via increased plasma adropin and nitrate/nitrite induced by high-intensity interval training in patients with type 2 diabetes. ( Ariabood, E; Asvadi-Fard, M; Bigi, MAB; Davoodi, M; Gaeini, AA; Ghardashi-Afousi, A; Hesamabadi, BK; Izadi, MR, 2022)
"Vascular insulin resistance is a feature of obesity and type 2 diabetes that contributes to the genesis of vascular disease and glycemic dysregulation."1.72Young Women Are Protected Against Vascular Insulin Resistance Induced by Adoption of an Obesogenic Lifestyle. ( Jurrissen, TJ; Manrique-Acevedo, C; Martinez-Lemus, LA; McMillan, NJ; Padilla, J; Smith, JA; Soares, RN, 2022)
"Type 2 diabetes was induced using a low-dose of streptozotocin (25 mg/kg) combined with high-fat diet."1.72Effect of oral nitrite administration on gene expression of SNARE proteins involved in insulin secretion from pancreatic islets of male type 2 diabetic rats. ( Afzali, H; Ghasemi, A; Jeddi, S, 2022)
"Decreased nitric oxide bioavailability in skin contributes to impaired wound healing in type 2 diabetes (T2D)."1.56Acidified nitrite improves wound healing in type 2 diabetic rats: Role of oxidative stress and inflammation. ( Afzali, H; Ghasemi, A; Jeddi, S; Kashfi, K; Khaksari, M; Norouzirad, R, 2020)
" Correlation analysis showed in the overall population that the less NO and EETs bioavailability increases during heating, the more flow-mediated dilatation is reduced."1.51Altered bioavailability of epoxyeicosatrienoic acids is associated with conduit artery endothelial dysfunction in type 2 diabetic patients. ( Bellien, J; Cailleux, AF; Duflot, T; Iacob, M; Joannidès, R; Lamoureux, F; Leuillier, M; Li, D; Moreau-Grangé, L; Morisseau, C; Prévost, G; Rémy-Jouet, I; Renet, S; Richard, V; Roche, C; Wils, J, 2019)
"Body weight was measured weekly."1.48Effect of long-term nitrite administration on browning of white adipose tissue in type 2 diabetic rats: A stereological study. ( Abdollahifar, MA; Ghasemi, A; Haeri Rohani, SA; Jeddi, S; Piryaei, A; Varzandi, T; Zadeh-Vakili, A, 2018)
"Reduced bioavailability of nitric oxide (NO) is associated with pathogenesis of type 2 diabetes."1.46Nitrite increases glucose-stimulated insulin secretion and islet insulin content in obese type 2 diabetic male rats. ( Bakhtiarzadeh, F; Farrokhfall, K; Ghasemi, A; Gheibi, S; Jeddi, S; Zardooz, H, 2017)
"Melatonin administration in NIDDM patients resulted in a significant increase in the morning melatonin concentration and SOD-1 activity, and a reduction in the MDA level and Cp oxidase activity."1.35Melatonin improves oxidative stress parameters measured in the blood of elderly type 2 diabetic patients. ( Bartosz, G; Czuczejko, J; Kedziora, J; Kedziora-Kornatowska, K; Kornatowski, T; Kozakiewicz, M; Pawluk, H; Szewczyk-Golec, K, 2009)
"Thirty-six patients with type 2 diabetes (age group 34-66 years, 19 male and 17 female) were allocated to the study."1.35Possible impact of impaired double-stranded RNA degradation and nitrosative stress on immuno-inflammatory cascade in type 2 diabetes. ( Basic, J; Jevtovic-Stoimenov, T; Kamenov, B; Kocic, GM; Kocic, R; Nikolic, G; Pavlovic, D; Pavlovic, R; Pavlovic, V; Sokolovic, D; Stojanovic, S; Veljkovic, A, 2009)
" We report for the first time that CYP 2C inhibition reduces oxidative stress (measured as plasma levels of 8-isoprostane), increases NO bioavailability (measured as NO(2)(-)) and restores endothelial function in db/db mice without affecting plasma glucose levels."1.35Sulfaphenazole treatment restores endothelium-dependent vasodilation in diabetic mice. ( Elmi, S; Granville, DJ; Hunter, AL; Khazaei, M; Laher, I; Moien-Afshari, F; Rahman, MM; Sallam, NA; Teng, X, 2008)
" We examined aortic endothelial cell function, NO bioavailability and various biomarkers of oxidative stress."1.35Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db mice. ( Brownsey, RW; Elmi, S; Ghosh, S; Khazaei, M; Kieffer, TJ; Laher, I; Moien-Afshari, F; Rahman, MM; Sallam, N, 2008)
"Diabetic nephropathy was exacerbated drastically by a nitric oxide synthase inhibitor and mildly by a NO precursor."1.33Chronic inhibition of nitric oxide production aggravates diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty rats. ( Higuchi, M; Hora, K; Kamijo, H, 2006)
" bioavailability and protect against hepatic ischemia-reperfusion (I-R) injury in type 2 diabetes mellitus."1.33eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling. ( Champion, HC; Dugas, TR; Duranski, MR; Elrod, JW; Greer, JJ; Kevil, CG; Langston, W; Lefer, DJ; Tao, L, 2006)
"The 39 patients with type 2 diabetes included in this study were divided by stage of DR into 3 groups: group A, those without DR; group B, those with background/preproliferative DR; and group C, those with proliferative DR."1.32Basal serum nitric oxide levels in patients with type 2 diabetes mellitus and different stages of retinopathy. ( Biçer, N; Güner, G; Ozbay, D; Ozden, S; Tatlipinar, S; Yaylali, V; Yildirim, C, 2003)
"Both uncontrolled hypertension and type II diabetes mellitus, but not smoking, are associated with impaired vascular smooth-muscle reactivity induced by NO donors."1.32Uncontrolled hypertension, uncompensated type II diabetes, and smoking have different patterns of vascular dysfunction. ( Cittadino, M; Moreno, H; Sabha, M; Sousa, MG; Tácito, LH; Tanus-Santos, JE; Yugar-Toledo, JC, 2004)
" The differences appear to be due to defective nitric oxide production or bioavailability and might explain some of the propensity to develop end-stage renal disease."1.31Defective nitric oxide production and functional renal reserve in patients with type 2 diabetes who have microalbuminuria of African and Asian compared with white origin. ( Dalton, RN; Denver, E; Earle, KA; Mehrotra, S; Swaminathan, R, 2001)
" Chronic administration of L-NAME to rats induced reduced NO production and hypertension in both strains of rats."1.31Chronic feeding of a nitric oxide synthase inhibitor induces postprandial hypertriglyceridemia in type 2 diabetic model rats, Otsuka Long-Evans Tokushima Fatty rats, but not in nondiabetic rats. ( Ishimura, N; Nakaya, Y; Takahashi, A; Takishita, E, 2002)
"Moreover, in IDDM patients reduced nitrate/nitrite excretion was strongly associated with elevated plasmatic beta-thromboglobulin levels."1.30The association of reduced endothelium derived relaxing factor-NO production with endothelial damage and increased in vivo platelet activation in patients with diabetes mellitus. ( Huszka, M; Kaplar, M; Laszlo, P; Palatka, K; Rejto, L; Tornai, I; Udvardy, M, 1997)
" This study, taken with previous observations, suggests that factors other than diminished basal NO production, such as reduced bioavailability of NO probably due to the augmented production of superoxide anion with subsequently increased inactivation of NO, contribute to the high incidence of vascular disease in patients with noninsulin-dependent diabetes mellitus."1.30Basal nitric oxide production is not reduced in patients with noninsulin-dependent diabetes mellitus. ( Andreoni, S; Carotta, M; Carzaniga, G; Catalano, M; Jun, T; Perilli, E; Scandale, G, 1997)
"Almost similar nitrite plasma levels in IDDM (17 +/- 0."1.30Nitrite plasma levels in type 1 and 2 diabetics with and without complications. ( Ferlito, S; Gallina, M, 1998)

Research

Studies (92)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (6.52)18.2507
2000's38 (41.30)29.6817
2010's36 (39.13)24.3611
2020's12 (13.04)2.80

Authors

AuthorsStudies
Velagic, A1
Li, JC1
Qin, CX1
Li, M1
Deo, M1
Marshall, SA1
Anderson, D1
Woodman, OL1
Horowitz, JD1
Kemp-Harper, BK1
Ritchie, RH1
Bock, JM2
Hughes, WE2
Ueda, K2
Feider, AJ2
Hanada, S2
Casey, DP2
Davoodi, M1
Hesamabadi, BK1
Ariabood, E1
Izadi, MR1
Ghardashi-Afousi, A1
Bigi, MAB1
Asvadi-Fard, M1
Gaeini, AA1
Shenouda, N1
Patik, JC1
Edwards, DG1
Hoseini, R1
Rahim, HA1
Ahmed, JK1
Smith, JA1
Soares, RN1
McMillan, NJ1
Jurrissen, TJ1
Martinez-Lemus, LA1
Padilla, J1
Manrique-Acevedo, C1
Turner, KD1
Kronemberger, A1
Bae, D1
de Sousa, LGO1
Harris, MP1
Anderson, EJ1
Bodine, SC1
Zimmerman, MB1
Lira, VA1
Srour, B1
Chazelas, E1
Druesne-Pecollo, N1
Esseddik, Y1
de Edelenyi, FS1
Agaësse, C1
De Sa, A1
Lutchia, R1
Debras, C1
Sellem, L1
Huybrechts, I1
Julia, C1
Kesse-Guyot, E1
Allès, B1
Galan, P1
Hercberg, S1
Pierre, F1
Deschasaux-Tanguy, M1
Touvier, M1
Gheibi, S2
Jeddi, S5
Carlström, M2
Kashfi, K2
Ghasemi, A5
Halim, AA1
Alsayed, B1
Embarak, S1
Yaseen, T1
Dabbous, S1
Fontaine, O1
Dueluzeau, R1
Raibaud, P1
Chabanet, C1
Popoff, MR1
Badoual, J1
Gabilan, JC1
Andremont, A1
Gómez, L1
Andrés, S1
Sánchez, J1
Alonso, JM1
Rey, J1
López, F1
Jiménez, A1
Yan, Z1
Zhou, L1
Zhao, Y3
Wang, J6
Huang, L2
Hu, K1
Liu, H4
Wang, H3
Guo, Z1
Song, Y1
Huang, H4
Yang, R1
Owen, TW1
Al-Kaysi, RO1
Bardeen, CJ1
Cheng, Q1
Wu, S1
Cheng, T1
Zhou, X1
Wang, B4
Zhang, Q4
Wu, X2
Yao, Y3
Ochiai, T1
Ishiguro, H2
Nakano, R2
Kubota, Y2
Hara, M1
Sunada, K1
Hashimoto, K1
Kajioka, J1
Fujishima, A1
Jiao, J3
Gai, QY3
Wang, W2
Zang, YP2
Niu, LL2
Fu, YJ3
Wang, X4
Yao, LP1
Qin, QP1
Wang, ZY1
Liu, J4
Aleksic Sabo, V1
Knezevic, P1
Borges-Argáez, R1
Chan-Balan, R1
Cetina-Montejo, L1
Ayora-Talavera, G1
Sansores-Peraza, P1
Gómez-Carballo, J1
Cáceres-Farfán, M1
Jang, J1
Akin, D1
Bashir, R1
Yu, Z1
Zhu, J2
Jiang, H1
He, C2
Xiao, Z1
Xu, J2
Sun, Q1
Han, D1
Lei, H1
Zhao, K2
Zhu, L1
Li, X5
Fu, H2
Wilson, BK1
Step, DL1
Maxwell, CL1
Gifford, CA1
Richards, CJ1
Krehbiel, CR1
Warner, JM1
Doerr, AJ1
Erickson, GE1
Guretzky, JA1
Rasby, RJ1
Watson, AK1
Klopfenstein, TJ1
Sun, Y4
Liu, Z3
Pham, TD1
Lee, BK1
Yang, FC1
Wu, KH1
Lin, WP1
Hu, MK1
Lin, L3
Shao, J1
Sun, M1
Xu, G1
Zhang, X6
Xu, N1
Wang, R1
Liu, S1
He, H1
Dong, X2
Yang, M2
Yang, Q1
Duan, S1
Yu, Y2
Han, J2
Zhang, C3
Chen, L2
Yang, X1
Li, W3
Wang, T2
Campbell, DA1
Gao, K1
Zager, RA1
Johnson, ACM1
Guillem, A1
Keyser, J1
Singh, B1
Steubl, D1
Schneider, MP1
Meiselbach, H1
Nadal, J1
Schmid, MC1
Saritas, T1
Krane, V1
Sommerer, C1
Baid-Agrawal, S1
Voelkl, J1
Kotsis, F1
Köttgen, A1
Eckardt, KU1
Scherberich, JE1
Li, H5
Yao, L2
Sun, L3
Zhu, Z1
Naren, N1
Zhang, XX2
Gentile, GL1
Rupert, AS1
Carrasco, LI1
Garcia, EM1
Kumar, NG1
Walsh, SW1
Jefferson, KK1
Guest, RL1
Samé Guerra, D1
Wissler, M1
Grimm, J1
Silhavy, TJ1
Lee, JH2
Yoo, JS1
Kim, Y1
Kim, JS2
Lee, EJ2
Roe, JH1
Delorme, M1
Bouchard, PA1
Simon, M1
Simard, S1
Lellouche, F1
D'Urzo, KA1
Mok, F1
D'Urzo, AD1
Koneru, B1
Lopez, G1
Farooqi, A1
Conkrite, KL1
Nguyen, TH1
Macha, SJ1
Modi, A1
Rokita, JL1
Urias, E1
Hindle, A1
Davidson, H1
Mccoy, K1
Nance, J1
Yazdani, V1
Irwin, MS1
Yang, S1
Wheeler, DA1
Maris, JM1
Diskin, SJ1
Reynolds, CP1
Abhilash, L1
Kalliyil, A1
Sheeba, V1
Hartley, AM2
Meunier, B2
Pinotsis, N1
Maréchal, A2
Xu, JY1
Genko, N1
Haraux, F1
Rich, PR1
Kamalanathan, M1
Doyle, SM1
Xu, C1
Achberger, AM1
Wade, TL1
Schwehr, K1
Santschi, PH1
Sylvan, JB1
Quigg, A1
Leong, W1
Xu, W2
Gao, S1
Zhai, X1
Wang, C2
Gilson, E1
Ye, J1
Lu, Y1
Yan, R1
Zhang, Y7
Hu, Z1
You, Q1
Cai, Q1
Yang, D1
Gu, S1
Dai, H1
Zhao, X1
Gui, C1
Gui, J1
Wu, PK1
Hong, SK1
Starenki, D1
Oshima, K1
Shao, H1
Gestwicki, JE1
Tsai, S1
Park, JI1
Wang, Y7
Zhao, R1
Gu, Z1
Dong, C2
Guo, G1
Li, L4
Barrett, HE1
Meester, EJ1
van Gaalen, K1
van der Heiden, K1
Krenning, BJ1
Beekman, FJ1
de Blois, E1
de Swart, J1
Verhagen, HJ1
Maina, T1
Nock, BA1
Norenberg, JP1
de Jong, M1
Gijsen, FJH1
Bernsen, MR1
Martínez-Milla, J1
Galán-Arriola, C1
Carnero, M1
Cobiella, J1
Pérez-Camargo, D1
Bautista-Hernández, V1
Rigol, M1
Solanes, N1
Villena-Gutierrez, R1
Lobo, M1
Mateo, J1
Vilchez-Tschischke, JP1
Salinas, B1
Cussó, L1
López, GJ1
Fuster, V1
Desco, M1
Sanchez-González, J1
Ibanez, B1
van den Berg, P1
Schweitzer, DH1
van Haard, PMM1
Geusens, PP1
van den Bergh, JP1
Zhu, X1
Huang, X2
Xu, H2
Yang, G2
Lin, Z1
Salem, HF1
Nafady, MM1
Kharshoum, RM1
Abd El-Ghafar, OA1
Farouk, HO1
Domiciano, D1
Nery, FC1
de Carvalho, PA1
Prudente, DO1
de Souza, LB1
Chalfun-Júnior, A1
Paiva, R1
Marchiori, PER1
Lu, M2
An, Z1
Jiang, J2
Li, J7
Du, S1
Zhou, H1
Cui, J1
Wu, W1
Liu, Y7
Song, J1
Lian, Q1
Uddin Ahmad, Z1
Gang, DD1
Konggidinata, MI1
Gallo, AA1
Zappi, ME1
Yang, TWW1
Johari, Y1
Burton, PR1
Earnest, A1
Shaw, K1
Hare, JL1
Brown, WA1
Kim, GA1
Han, S1
Choi, GH1
Choi, J1
Lim, YS1
Gallo, A1
Cancelli, C1
Ceron, E1
Covino, M1
Capoluongo, E1
Pocino, K1
Ianiro, G1
Cammarota, G1
Gasbarrini, A1
Montalto, M1
Somasundar, Y1
Lu, IC1
Mills, MR1
Qian, LY1
Olivares, X1
Ryabov, AD1
Collins, TJ1
Zhao, L1
Doddipatla, S1
Thomas, AM1
Nikolayev, AA1
Galimova, GR1
Azyazov, VN1
Mebel, AM1
Kaiser, RI1
Guo, S1
Yang, P1
Yu, X2
Wu, Y2
Zhang, H1
Yu, B2
Han, B1
George, MW1
Moor, MB1
Bonny, O1
Langenberg, E1
Paik, H1
Smith, EH1
Nair, HP1
Hanke, I1
Ganschow, S1
Catalan, G1
Domingo, N1
Schlom, DG1
Assefa, MK1
Wu, G2
Hayton, TW1
Becker, B1
Enikeev, D1
Netsch, C1
Gross, AJ1
Laukhtina, E1
Glybochko, P1
Rapoport, L1
Herrmann, TRW1
Taratkin, M1
Dai, W1
Shi, J2
Carreno, J1
Kloner, RA1
Pickersgill, NA1
Vetter, JM1
Kim, EH1
Cope, SJ1
Du, K1
Venkatesh, R1
Giardina, JD1
Saad, NES1
Bhayani, SB1
Figenshau, RS1
Eriksson, J1
Landfeldt, E1
Ireland, S1
Jackson, C1
Wyatt, E1
Gaudig, M1
Stancill, JS1
Happ, JT1
Broniowska, KA1
Hogg, N1
Corbett, JA1
Tang, LF1
Bi, YL1
Fan, Y2
Sun, YB1
Wang, AL1
Xiao, BH1
Wang, LF1
Qiu, SW1
Guo, SW1
Wáng, YXJ1
Sun, J2
Chu, S1
Pan, Q1
Li, D3
Zheng, S2
Ma, L1
Wang, L3
Hu, T1
Wang, F1
Han, Z1
Yin, Z1
Ge, X1
Xie, K1
Lei, P1
Dias-Santagata, D1
Lennerz, JK1
Sadow, PM1
Frazier, RP1
Govinda Raju, S1
Henry, D1
Chung, T1
Kherani, J1
Rothenberg, SM1
Wirth, LJ1
Marti, CN1
Choi, NG1
Bae, SJ1
Ni, L1
Luo, X1
Dai, T1
Yang, Y3
Lee, R1
Fleischer, AS1
Wemhoff, AP1
Ford, CR1
Kleppinger, EL1
Helms, K1
Bush, AA1
Luna-Abanto, J1
García Ruiz, L1
Laura Martinez, J1
Álvarez Larraondo, M1
Villoslada Terrones, V1
Dukic, L1
Maric, N1
Simundic, AM1
Chogtu, B1
Ommurugan, B1
Thomson, SR1
Kalthur, SG1
Benidir, M1
El Massoudi, S1
El Ghadraoui, L1
Lazraq, A1
Benjelloun, M1
Errachidi, F1
Cassar, M1
Law, AD1
Chow, ES1
Giebultowicz, JM1
Kretzschmar, D1
Salonurmi, T1
Nabil, H1
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Hyötyläinen, T1
Hautajärvi, H1
Savolainen, MJ1
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Guo, W1
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Liu, T2
Chen, D5
Luo, K1
He, Z2
Zheng, G1
Xu, F1
Sun, W1
Yin, F1
van Hest, JCM1
Du, L2
Shi, X1
Kang, S1
Duan, W1
Zhang, S2
Feng, J2
Qi, N1
Shen, G1
Ren, H1
Shang, Q1
Zhao, W2
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Jiang, X2
Alame, M1
Cornillot, E1
Cacheux, V1
Tosato, G1
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De Oliveira, L1
Gofflot, S1
Delvenne, P1
Turtoi, E1
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Nishiyama, M1
Turtoi, A1
Costes-Martineau, V1
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Guo, Q1
Quan, M1
Dong, J1
Bai, J1
Han, R1
Cai, Y1
Lv, YQ1
Chen, Q1
Lyu, HD1
Deng, L1
Zhou, D1
Xiao, X1
De Langhe, S1
Billadeau, DD1
Lou, Z1
Zhang, JS1
Xue, Z1
Shen, XD1
Gao, F1
Busuttil, RW1
Kupiec-Weglinski, JW1
Ji, H1
Otano, I1
Alvarez, M1
Minute, L1
Ochoa, MC1
Migueliz, I1
Molina, C1
Azpilikueta, A1
de Andrea, CE1
Etxeberria, I1
Sanmamed, MF1
Teijeira, Á1
Berraondo, P1
Melero, I1
Zhong, Z1
Xie, X1
Yu, Q1
Zhou, C1
Liu, C2
Liu, W1
Chen, W1
Yin, Y1
Li, CW1
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Zhou, Q1
Hu, B1
Fu, P1
Atyah, M1
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Pavlov, IA1
Drel, VR1
Lyzogubov, VV1
Ilnytska, O1
Bell, SR1
Tibrewala, J1
Groves, JT1
Obrosova, IG1
Elmi, S2
Sallam, NA1
Rahman, MM2
Teng, X1
Hunter, AL1
Moien-Afshari, F2
Khazaei, M2
Granville, DJ1
Laher, I2
Mayret-Mesquiti, M1
Pérez-Méndez, O1
Rodríguez, ME1
Fortoul, TI1
Gorocica, P1
Bernal-Alcántara, D1
Montaño, LF1
Alvarado-Vasquez, N1
Takenouchi, Y1
Ghosh, S1
Sallam, N1
Kieffer, TJ1
Brownsey, RW1
Virtanen, SM1
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Huszka, M1
Kaplar, M1
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Tornai, I1
Palatka, K1
Laszlo, P1
Udvardy, M1
Sakamoto, S1
Minami, K1
Niwa, Y1
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Mizuno, A1
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Catalano, M1
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Kurioka, S2
Koshimura, K2
Sugitani, M1
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Kato, Y2
Daimon, M1
Sugiyama, K1
Saitoh, T1
Yamaguchi, H1
Hirata, A1
Ohnuma, H1
Igarashi, M1
Eguchi, H1
Manaka, H1
Kato, T1
Tonolo, G1
Melis, MG1
Formato, M1
Angius, MF1
Carboni, A1
Brizzi, P1
Ciccarese, M1
Cherchi, GM1
Maioli, M1
Kagota, S1
Yamaguchi, Y1
Nakamura, K1
Kunitomo, M1
Aydin, A1
Orhan, H1
Sayal, A1
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Sahin, G1
Işimer, A1
Francesconi, F1
Mingardi, R1
deKreutzenberg, S1
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Sugimoto, H1
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Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Nitrate Supplementation and Exercise Tolerance in Patients With Type 2 Diabetes[NCT02804932]65 participants (Anticipated)Interventional2016-06-30Recruiting
Determination of the Mechanisms Involved in Conduit Artery Endothelial Dysfunction in Type 2 Diabetes[NCT02311075]48 participants (Actual)Interventional2014-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for nitrites and Diabetes Mellitus, Type 2

ArticleYear
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
Metabolic Effects of Dietary Nitrate in Health and Disease.
    Cell metabolism, 2018, Jul-03, Volume: 28, Issue:1

    Topics: Animals; Cardiovascular System; Diabetes Mellitus, Type 2; Diet; Humans; Metabolic Syndrome; Mice; M

2018
Red meat, dietary heme iron, and risk of type 2 diabetes: the involvement of advanced lipoxidation endproducts.
    Advances in nutrition (Bethesda, Md.), 2013, Jul-01, Volume: 4, Issue:4

    Topics: Animals; Cohort Studies; Diabetes Mellitus, Type 2; Diet; Female; Ferritins; Food Handling; Glycatio

2013
Dietary inorganic nitrate: From villain to hero in metabolic disease?
    Molecular nutrition & food research, 2016, Volume: 60, Issue:1

    Topics: Adipose Tissue; Biological Availability; Diabetes Mellitus, Type 2; Diet; Heart; Humans; Hypertensio

2016
Dietary factors in the aetiology of diabetes.
    Annals of medicine, 1994, Volume: 26, Issue:6

    Topics: Animals; Case-Control Studies; Child; Cohort Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus,

1994

Trials

18 trials available for nitrites and Diabetes Mellitus, Type 2

ArticleYear
Dietary Inorganic Nitrate/Nitrite Supplementation Reduces Central and Peripheral Blood Pressure in Patients With Type 2 Diabetes Mellitus.
    American journal of hypertension, 2022, 09-01, Volume: 35, Issue:9

    Topics: Beta vulgaris; Blood Pressure; Diabetes Mellitus, Type 2; Dietary Supplements; Double-Blind Method;

2022
Concurrent alteration in inflammatory biomarker gene expression and oxidative stress: how aerobic training and vitamin D improve T2DM.
    BMC complementary medicine and therapies, 2022, Jun-22, Volume: 22, Issue:1

    Topics: Adult; Antioxidants; Biomarkers; C-Reactive Protein; Cytokines; Diabetes Mellitus, Type 2; Exercise;

2022
Effects of Combined Inorganic Nitrate and Nitrite Supplementation on Cardiorespiratory Fitness and Skeletal Muscle Oxidative Capacity in Type 2 Diabetes: A Pilot Randomized Controlled Trial.
    Nutrients, 2022, Oct-25, Volume: 14, Issue:21

    Topics: Aged; Beta vulgaris; Carbohydrates; Cardiorespiratory Fitness; Diabetes Mellitus, Type 2; Dietary Su

2022
    The Egyptian journal of chest diseases and tuberculosis, 2016, Volume: 65, Issue:1

    Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P

2016
The effects of combined magnesium and zinc supplementation on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease.
    Lipids in health and disease, 2020, May-28, Volume: 19, Issue:1

    Topics: Antioxidants; Blood Glucose; C-Reactive Protein; Cholesterol, HDL; Coronary Disease; Diabetes Mellit

2020
Oxidative stress and nitrate/nitrite (NOx) status following citrulline supplementation in type 2 diabetes: a randomised, double-blind, placebo-controlled trial.
    Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2021, Volume: 34, Issue:1

    Topics: Adult; Antioxidants; Blood Glucose; Citrulline; Diabetes Mellitus, Type 2; Dietary Supplements; Doub

2021
Low nitric oxide bioavailability is associated with better responses to sildenafil in patients with erectile dysfunction.
    Naunyn-Schmiedeberg's archives of pharmacology, 2013, Volume: 386, Issue:9

    Topics: Adult; Aged; Biological Availability; Diabetes Mellitus, Type 2; Erectile Dysfunction; Glutathione;

2013
Vitamin E Improves Serum Paraoxonase-1 Activity and Some Metabolic Factors in Patients with Type 2 Diabetes: No Effects on Nitrite/Nitrate Levels.
    Journal of the American College of Nutrition, 2016, Volume: 35, Issue:6

    Topics: Adult; Antioxidants; Aryldialkylphosphatase; Blood Glucose; Diabetes Complications; Diabetes Mellitu

2016
The impact of pioglitazone on ADMA and oxidative stress markers in patients with type 2 diabetes.
    Primary care diabetes, 2012, Volume: 6, Issue:2

    Topics: Academic Medical Centers; Arginine; Biomarkers; Cross-Over Studies; Diabetes Mellitus, Type 2; Dinop

2012
The effect of different training programs on antioxidant status, oxidative stress, and metabolic control in type 2 diabetes.
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2012, Volume: 37, Issue:2

    Topics: Adult; Aged; Antioxidants; Biomarkers; Blood Glucose; Body Composition; Catalase; Diabetes Mellitus,

2012
Angiotensin II receptor blockade reduces salt sensitivity of blood pressure through restoration of renal nitric oxide synthesis in patients with diabetic nephropathy.
    Journal of the renin-angiotensin-aldosterone system : JRAAS, 2013, Volume: 14, Issue:1

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Angiotensin Receptor Antagonists; Biopterins; Blood Pressu

2013
Decrease of postprandial endothelial dysfunction by spice mix added to high-fat hamburger meat in men with Type 2 diabetes mellitus.
    Diabetic medicine : a journal of the British Diabetic Association, 2013, Volume: 30, Issue:5

    Topics: Animals; Blood Glucose; Cattle; Cooking; Diabetes Mellitus, Type 2; Diet, High-Fat; Endothelium, Vas

2013
Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes.
    Free radical biology & medicine, 2013, Volume: 60

    Topics: Aged; Beta vulgaris; Blood Pressure; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Dietary Sup

2013
L-arginine infusion decreases plasma total homocysteine concentrations through increased nitric oxide production and decreased oxidative status in Type II diabetic patients.
    Diabetologia, 2002, Volume: 45, Issue:8

    Topics: Arginine; Blood Pressure; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Female

2002
No effects of acute hyperglycaemia and hyperinsulinaemia on skin microcirculation and endothelial markers in Type II diabetes mellitus.
    Scandinavian journal of clinical and laboratory investigation, 2004, Volume: 64, Issue:2

    Topics: Antigens; Biomarkers; Capillary Permeability; Diabetes Mellitus, Type 2; Endothelial Cells; Fluoresc

2004
Additive effects of Simvastatin beyond its effects on LDL cholesterol in hypertensive type 2 diabetic patients.
    European journal of clinical investigation, 2000, Volume: 30, Issue:11

    Topics: Albuminuria; Anticholesteremic Agents; Apolipoproteins; Blood Pressure; Cholesterol, LDL; Cholestyra

2000
Effect of metabolic control on nitrite and nitrate metabolism in type 2 diabetic patients.
    Clinical and experimental pharmacology & physiology, 2001, Volume: 28, Issue:7

    Topics: Blood Glucose; Diabetes Mellitus, Type 2; Diet; Energy Intake; Female; Humans; Male; Middle Aged; Ni

2001
Paradoxical decrease in plasma NOx by L-arginine load in diabetic and non-diabetic subjects.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2002, Volume: 24, Issue:3

    Topics: Arginine; Blood Glucose; Blood Pressure; Cyclic GMP; Diabetes Mellitus, Type 2; Endothelium, Vascula

2002

Other Studies

70 other studies available for nitrites and Diabetes Mellitus, Type 2

ArticleYear
Cardioprotective actions of nitroxyl donor Angeli's salt are preserved in the diabetic heart and vasculature in the face of nitric oxide resistance.
    British journal of pharmacology, 2022, Volume: 179, Issue:16

    Topics: Animals; Diabetes Mellitus, Type 2; Male; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitrogen Oxid

2022
Improved blood pressure and flow-mediated dilatation via increased plasma adropin and nitrate/nitrite induced by high-intensity interval training in patients with type 2 diabetes.
    Experimental physiology, 2022, Volume: 107, Issue:8

    Topics: Aged; Blood Pressure; Diabetes Mellitus, Type 2; Dilatation; High-Intensity Interval Training; Human

2022
Reflecting on the Blood Pressure Lowering Effects of Inorganic Nitrate Supplementation in Patients With Type 2 Diabetes.
    American journal of hypertension, 2022, 09-01, Volume: 35, Issue:9

    Topics: Blood Pressure; Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Nitrates; Nitrites

2022
Young Women Are Protected Against Vascular Insulin Resistance Induced by Adoption of an Obesogenic Lifestyle.
    Endocrinology, 2022, 10-11, Volume: 163, Issue:11

    Topics: Blood Glucose; Diabetes Mellitus, Type 2; Female; Humans; Insulin; Insulin Resistance; Life Style; M

2022
Dietary exposure to nitrites and nitrates in association with type 2 diabetes risk: Results from the NutriNet-Santé population-based cohort study.
    PLoS medicine, 2023, Volume: 20, Issue:1

    Topics: Adult; Cohort Studies; Diabetes Mellitus, Type 2; Diet; Dietary Exposure; Drinking Water; Female; Fo

2023
Hydrogen sulfide potentiates the favorable metabolic effects of inorganic nitrite in type 2 diabetic rats.
    Nitric oxide : biology and chemistry, 2019, 11-01, Volume: 92

    Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models,

2019
Acidified nitrite improves wound healing in type 2 diabetic rats: Role of oxidative stress and inflammation.
    Nitric oxide : biology and chemistry, 2020, 10-01, Volume: 103

    Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hydrogen-Ion Conc

2020
Effect of oral nitrite administration on gene expression of SNARE proteins involved in insulin secretion from pancreatic islets of male type 2 diabetic rats.
    Biomedical journal, 2022, Volume: 45, Issue:2

    Topics: Animals; C-Peptide; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gene Expression; Glu

2022
Levels of Nitric Oxide Metabolites and Myeloperoxidase in Subjects with Type 2 Diabetes Mellitus on Metformin Therapy .
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2019, Volume: 127, Issue:1

    Topics: Adult; Aged; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Glycated Hemoglobin; Humans;

2019
Effect of long-term nitrite administration on browning of white adipose tissue in type 2 diabetic rats: A stereological study.
    Life sciences, 2018, Aug-15, Volume: 207

    Topics: Adipocytes; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Body Weight; Cyclic GMP; Diabetes

2018
Altered bioavailability of epoxyeicosatrienoic acids is associated with conduit artery endothelial dysfunction in type 2 diabetic patients.
    Cardiovascular diabetology, 2019, 03-18, Volume: 18, Issue:1

    Topics: Aged; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Eicosanoid

2019
The effect of high-dose insulin analog initiation therapy on lipid peroxidation products and oxidative stress markers in type 2 diabetic patients.
    Oxidative medicine and cellular longevity, 2013, Volume: 2013

    Topics: Adult; Aged; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Dinoprost; Drug Therapy, Combinat

2013
Increased erythrocytes by-products of arginine catabolism are associated with hyperglycemia and could be involved in the pathogenesis of type 2 diabetes mellitus.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Adult; Aged; Arginine; Blood Glucose; Carbon Isotopes; Case-Control Studies; Citrulline; Diabetes Me

2013
Oxidant status and lipid composition of erythrocyte membranes in patients with type 2 diabetes, chronic liver damage, and a combination of both pathologies.
    Oxidative medicine and cellular longevity, 2013, Volume: 2013

    Topics: Case-Control Studies; Cholesterol; Cysteine; Diabetes Mellitus, Type 2; Erythrocyte Membrane; Humans

2013
The combined effect of metformin and L-cysteine on inflammation, oxidative stress and insulin resistance in streptozotocin-induced type 2 diabetes in rats.
    European journal of pharmacology, 2013, Aug-15, Volume: 714, Issue:1-3

    Topics: Animals; Body Weight; C-Reactive Protein; Caspase 3; Chemokine CCL2; Cysteine; Cytochromes c; Diabet

2013
L-arginine catabolism is driven mainly towards nitric oxide synthesis in the erythrocytes of patients with type 2 diabetes at first clinical onset.
    Annals of clinical biochemistry, 2015, Volume: 52, Issue:Pt 1

    Topics: Arginase; Arginine; Case-Control Studies; Diabetes Mellitus, Type 2; Electrophoresis, Capillary; Ery

2015
Dietary nitrite supplementation improves insulin resistance in type 2 diabetic KKA(y) mice.
    Nitric oxide : biology and chemistry, 2015, Jan-30, Volume: 44

    Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Cytokines; Diabetes Mellitus, Experimental; Dia

2015
Increase in Red Blood Cell-Nitric Oxide Synthase Dependent Nitric Oxide Production during Red Blood Cell Aging in Health and Disease: A Study on Age Dependent Changes of Rheologic and Enzymatic Properties in Red Blood Cells.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Adult; Arginase; Biomarkers; Centrifugation, Density Gradient; Diabetes Mellitus, Type 2; Enzyme Inh

2015
Disrupted Nitric Oxide Metabolism from Type II Diabetes and Acute Exposure to Particulate Air Pollution.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Aged; Air Filters; Air Pollution; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Humans;

2015
Nitrite increases glucose-stimulated insulin secretion and islet insulin content in obese type 2 diabetic male rats.
    Nitric oxide : biology and chemistry, 2017, Apr-01, Volume: 64

    Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Eating; Glucose; I

2017
Nitric oxide levels in response to the patients with different stage of diabetes.
    Cellular and molecular biology (Noisy-le-Grand, France), 2017, Feb-22, Volume: 63, Issue:1

    Topics: Adult; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Insulin

2017
Modulation of neuro-inflammatory condition, acetylcholinesterase and antioxidant levels by genistein attenuates diabetes associated cognitive decline in mice.
    Chemico-biological interactions, 2017, Apr-25, Volume: 268

    Topics: Acetylcholinesterase; Animals; Anti-Inflammatory Agents; Antioxidants; Cognition Disorders; Diabetes

2017
Biomarkers of oxidative stress and endothelial dysfunction in glucose intolerance and diabetes mellitus.
    Clinical biochemistry, 2008, Volume: 41, Issue:18

    Topics: Arginine; Biomarkers; Body Mass Index; Diabetes Mellitus, Type 2; Endothelium; Female; Glucose Intol

2008
Semicarbazide-sensitive amine oxidase activity and total nitrite and nitrate concentrations in serum: novel biochemical markers for type 2 diabetes?
    Acta diabetologica, 2009, Volume: 46, Issue:2

    Topics: Administration, Oral; Aged; Aged, 80 and over; Albuminuria; Amine Oxidase (Copper-Containing); Bioma

2009
Eicosapentaenoic acid improves imbalance between vasodilator and vasoconstrictor actions of endothelium-derived factors in mesenteric arteries from rats at chronic stage of type 2 diabetes.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:1

    Topics: Animals; Blood Chemical Analysis; Blood Pressure; Blotting, Western; Chronic Disease; Diabetes Melli

2009
Melatonin improves oxidative stress parameters measured in the blood of elderly type 2 diabetic patients.
    Journal of pineal research, 2009, Volume: 46, Issue:3

    Topics: Aged; Aged, 80 and over; Analysis of Variance; Antioxidants; Diabetes Mellitus, Type 2; Dietary Supp

2009
Possible impact of impaired double-stranded RNA degradation and nitrosative stress on immuno-inflammatory cascade in type 2 diabetes.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2009, Volume: 117, Issue:9

    Topics: Adult; Aged; Animals; bcl-2-Associated X Protein; Blood Glucose; Cells, Cultured; DEAD-box RNA Helic

2009
Mechanisms underlying enhanced vasorelaxant response to protease-activated receptor 2-activating peptide in type 2 diabetic Goto-Kakizaki rat mesenteric artery.
    Peptides, 2009, Volume: 30, Issue:9

    Topics: Acetylcholine; Animals; Cyclooxygenase Inhibitors; Diabetes Mellitus, Type 2; Dose-Response Relation

2009
Role of macrophages in the development of pancreatic islet injury in spontaneously diabetic torii rats.
    Experimental animals, 2009, Volume: 58, Issue:4

    Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bone Density Conservation Agents;

2009
Modification of vascular and inflammation biomarkers after OGTT in overweight healthy and diabetic subjects.
    Microvascular research, 2010, Volume: 79, Issue:2

    Topics: Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glucose Tolerance Test; Humans; Male;

2010
Natural therapeutic magnesium lithospermate B potently protects the endothelium from hyperglycaemia-induced dysfunction.
    Cardiovascular research, 2010, Sep-01, Volume: 87, Issue:4

    Topics: Animals; Antioxidants; Apoptosis; Cell Adhesion; Cells, Cultured; Diabetes Mellitus, Type 2; Diabeti

2010
[Possibilities of correction of rheological properties of the blood and free radical processess in patients with acute myocardial infarction combined with type 2 diabetes mellitus].
    Kardiologiia, 2010, Volume: 50, Issue:5

    Topics: Arrhythmias, Cardiac; Blood Viscosity; Diabetes Mellitus, Type 2; Electrocardiography; Electrocardio

2010
Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line.
    Clinical science (London, England : 1979), 2011, Volume: 120, Issue:5

    Topics: Arachidonic Acid; Cell Survival; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase

2011
Arginase inhibition restores in vivo coronary microvascular function in type 2 diabetic rats.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:4

    Topics: Amino Acids; Animals; Arginase; Arginine; Blood Flow Velocity; Blood Glucose; Coronary Circulation;

2011
Correlation between total nitrite/nitrate concentrations and monoamine oxidase (types A and B) and semicarbazide-sensitive amine oxidase enzymatic activities in human mesenteric arteries from non-diabetic and type 2 diabetic patients.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2012, Volume: 45, Issue:1

    Topics: Aged; Amine Oxidase (Copper-Containing); Case-Control Studies; Diabetes Mellitus, Type 2; Female; Hu

2012
Enhanced estradiol-induced vasorelaxation in aortas from type 2 diabetic mice may reflect a compensatory role of p38 MAPK-mediated eNOS activation.
    Pflugers Archiv : European journal of physiology, 2012, Volume: 464, Issue:2

    Topics: Animals; Aorta; Diabetes Mellitus, Type 2; Disease Models, Animal; Estradiol; Estrogens; Female; In

2012
Iron increases liver injury through oxidative/nitrative stress in diabetic rats: Involvement of nitrotyrosination of glucokinase.
    Biochimie, 2012, Volume: 94, Issue:12

    Topics: Animals; Blotting, Western; Body Weight; Diabetes Mellitus, Type 2; Glucokinase; Iron; Iron Overload

2012
The importance of L-arginine metabolism modulation in diabetic patients with distal symmetric polyneuropathy.
    Journal of the neurological sciences, 2013, Jan-15, Volume: 324, Issue:1-2

    Topics: Aged; Arginase; Arginine; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Ty

2013
The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain.
    European journal of pharmacology, 2013, Jan-30, Volume: 700, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Body Weight; Brain; Cytokines; Diabetes Mellitus, Typ

2013
Association of (-)786T-C mutation of endothelial nitric oxide synthase gene with insulin resistance.
    Diabetologia, 2002, Volume: 45, Issue:11

    Topics: Adult; Aged; Asian People; Base Sequence; Blood Pressure; Cytidine; Diabetes Mellitus, Type 2; DNA P

2002
Protective role of oral antioxidant supplementation in ocular surface of diabetic patients.
    The British journal of ophthalmology, 2002, Volume: 86, Issue:12

    Topics: Administration, Oral; Aged; Ascorbic Acid; Conjunctiva; Diabetes Mellitus, Type 2; Female; Humans; M

2002
Basal serum nitric oxide levels in patients with type 2 diabetes mellitus and different stages of retinopathy.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2003, Volume: 38, Issue:5

    Topics: Adult; Aged; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Female; Humans;

2003
Uncontrolled hypertension, uncompensated type II diabetes, and smoking have different patterns of vascular dysfunction.
    Chest, 2004, Volume: 125, Issue:3

    Topics: Adult; Blood Flow Velocity; Cyclic GMP; Diabetes Mellitus, Type 2; Endothelium, Vascular; Humans; Hy

2004
Macrophage-derived cytokine and nitric oxide profiles in type I and type II diabetes mellitus: effect of thymoquinone.
    Acta diabetologica, 2005, Volume: 42, Issue:1

    Topics: Animals; Benzoquinones; Blood Glucose; Cytokines; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type

2005
Opposite relationship between circulating soluble CD14 concentration and endothelial function in diabetic and nondiabetic subjects.
    Thrombosis and haemostasis, 2005, Volume: 94, Issue:3

    Topics: Brachial Artery; C-Reactive Protein; Cross-Sectional Studies; Cyclic GMP; Diabetes Mellitus, Type 2;

2005
[Nitrite and nitrate content in selected herbal medicaments used in obesity and diabetes mellitus type 2 treatment].
    Przeglad lekarski, 2005, Volume: 62, Issue:8

    Topics: Diabetes Mellitus, Type 2; Humans; Nitrates; Nitrites; Obesity; Plants, Medicinal; Spectrophotometry

2005
Chronic inhibition of nitric oxide production aggravates diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty rats.
    Nephron. Physiology, 2006, Volume: 104, Issue:1

    Topics: Animals; Arginine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enzyme Inhibitors; Kidney Glom

2006
eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling.
    Circulation research, 2006, Jul-07, Volume: 99, Issue:1

    Topics: Animals; Biological Availability; Biopterins; Diabetes Mellitus, Type 2; Drug Synergism; Genetic The

2006
beta1 antagonist and beta2 agonist, celiprolol, restores the impaired endothelial dependent and independent responses and decreased TNFalpha in rat with type II diabetes.
    Life sciences, 2007, Jan-16, Volume: 80, Issue:6

    Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Agonists; Animals; Aorta, Abdomin

2007
Influence of eNOS haplotypes on the plasma nitric oxide products concentrations in hypertensive and type 2 diabetes mellitus patients.
    Nitric oxide : biology and chemistry, 2007, Volume: 16, Issue:3

    Topics: Adult; Aged; Diabetes Mellitus, Type 2; Female; Gene Frequency; Genotype; Haplotypes; Humans; Hypert

2007
Nitrosative stress and peripheral diabetic neuropathy in leptin-deficient (ob/ob) mice.
    Experimental neurology, 2007, Volume: 205, Issue:2

    Topics: Anesthesia; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Diabetic Nephropathies;

2007
Sulfaphenazole treatment restores endothelium-dependent vasodilation in diabetic mice.
    Vascular pharmacology, 2008, Volume: 48, Issue:1

    Topics: Acetylcholine; Animals; Antioxidants; Aorta, Thoracic; Biomarkers; Blood Glucose; Cyclic N-Oxides; C

2008
Hypertriglyceridemia is linked to reduced nitric oxide synthesis in women with hypertensive disorders of pregnancy.
    Hypertension in pregnancy, 2007, Volume: 26, Issue:4

    Topics: Adult; Blood Glucose; Blood Pressure; Body Mass Index; Cholesterol; Cholesterol, HDL; Cholesterol, L

2007
Possible involvement of Akt activity in endothelial dysfunction in type 2 diabetic mice.
    Journal of pharmacological sciences, 2008, Volume: 106, Issue:4

    Topics: Adrenomedullin; Animals; Aorta; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Clonidine;

2008
Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db mice.
    Diabetologia, 2008, Volume: 51, Issue:7

    Topics: Adipose Tissue; Animals; Antioxidants; Aorta; Body Weight; Diabetes Mellitus, Type 2; Diabetic Angio

2008
The association of reduced endothelium derived relaxing factor-NO production with endothelial damage and increased in vivo platelet activation in patients with diabetes mellitus.
    Thrombosis research, 1997, Apr-15, Volume: 86, Issue:2

    Topics: Adult; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes

1997
Effect of exercise training and food restriction on endothelium-dependent relaxation in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous NIDDM.
    Diabetes, 1998, Volume: 47, Issue:1

    Topics: Abdomen; Adipose Tissue; Animals; Blood Glucose; Body Composition; Body Weight; Cholesterol; Diabete

1998
Basal nitric oxide production is not reduced in patients with noninsulin-dependent diabetes mellitus.
    Vascular medicine (London, England), 1997, Volume: 2, Issue:4

    Topics: Aged; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Humans; Male;

1997
Nitrite plasma levels in type 1 and 2 diabetics with and without complications.
    Panminerva medica, 1998, Volume: 40, Issue:4

    Topics: Adult; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Middle Aged; Nitrites

1998
Analysis of urinary nitric oxide metabolites in healthy subjects.
    Endocrine journal, 1999, Volume: 46, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Arthritis, Rheumatoid; Chromatography, High Press

1999
Reverse correlation between urine nitric oxide metabolites and insulin resistance in patients with type 2 diabetes mellitus.
    Endocrine journal, 2000, Volume: 47, Issue:1

    Topics: Adult; Aged; Body Mass Index; Diabetes Mellitus, Type 2; Female; Glucose; Glucose Clamp Technique; H

2000
Increase in serum ceruloplasmin levels is correlated with a decrease of serum nitric oxide levels in type 2 diabetes.
    Diabetes care, 2000, Volume: 23, Issue:4

    Topics: Ceruloplasmin; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Ni

2000
Altered endothelium-dependent responsiveness in the aortas and renal arteries of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus.
    General pharmacology, 2000, Volume: 34, Issue:3

    Topics: Acetylcholine; Animals; Aorta; Biological Factors; Blood Glucose; Body Weight; Cardiovascular Agents

2000
Oxidative stress and nitric oxide related parameters in type II diabetes mellitus: effects of glycemic control.
    Clinical biochemistry, 2001, Volume: 34, Issue:1

    Topics: Adult; Aged; Case-Control Studies; Catalase; Cyclic GMP; Diabetes Mellitus, Type 2; Erythrocytes; Fe

2001
Nitric oxide system is involved in glomerular hyperfiltration in Japanese normo- and micro-albuminuric patients with type 2 diabetes.
    Diabetes research and clinical practice, 2001, Volume: 53, Issue:3

    Topics: Adult; Age Factors; Aged; Albuminuria; Animals; Blood Glucose; Blood Pressure; Creatinine; Cross-Sec

2001
Decreased nitric oxide end-products and its relationship with high density lipoprotein and oxidative stress in people with type 2 diabetes without complications.
    Diabetes research and clinical practice, 2001, Volume: 54, Issue:1

    Topics: Apolipoproteins; Blood Glucose; Body Mass Index; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Di

2001
Defective nitric oxide production and functional renal reserve in patients with type 2 diabetes who have microalbuminuria of African and Asian compared with white origin.
    Journal of the American Society of Nephrology : JASN, 2001, Volume: 12, Issue:10

    Topics: Africa; Aged; Albuminuria; Asian People; Black People; Diabetes Mellitus, Type 2; Ethnicity; Female;

2001
Effect in vitro of cyclic nucleotides-elevating agents on nitric oxide production by human granulocytes from type 2-diabetic patients.
    Diabetes & metabolism, 2002, Volume: 28, Issue:1

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aged; Cyclic AMP; Cyclic GMP; Diabetes Mellitus, Type 2; Fem

2002
Circadian variation in oxidative stress markers in healthy and type II diabetic men.
    Chronobiology international, 2002, Volume: 19, Issue:2

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Aged; Biomarkers; Case-Control Studies; Circadian Rhythm; Deoxyg

2002
Chronic feeding of a nitric oxide synthase inhibitor induces postprandial hypertriglyceridemia in type 2 diabetic model rats, Otsuka Long-Evans Tokushima Fatty rats, but not in nondiabetic rats.
    Metabolism: clinical and experimental, 2002, Volume: 51, Issue:6

    Topics: Animals; Arginine; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus; Diabetes Mellitus,

2002