Page last updated: 2024-10-19

nitrites and Dementia

nitrites has been researched along with Dementia in 13 studies

Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)

Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.

Research Excerpts

ExcerptRelevanceReference
" However, the probable role of this drug in aluminum chloride (AlCl3)-induced experimental dementia is yet to be explored."7.81Protective effect of a calcium channel blocker "diltiazem" on aluminum chloride-induced dementia in mice. ( Kaur, A; Rani, A; Sodhi, RK, 2015)
"These findings suggest the antidementia activity of caffeic acid against AlCl3 -induced dementia in rats."7.79Impact of caffeic acid on aluminium chloride-induced dementia in rats. ( Khan, KA; Krishnadas, N; Kumar, N; Mudgal, J; Nampoothiri, M; Nayak, PG; Rao, CM; Shenoy, RR, 2013)
" Furthermore, we evaluated the effect of anti-dementia drugs memantine, a NMDA antagonist, and donepezil, a cholinesterase inhibitor, on OKA ICV induced memory impairment."7.76Okadaic acid (ICV) induced memory impairment in rats: a suitable experimental model to test anti-dementia activity. ( Kamat, PK; Nath, C; Saxena, G; Shukla, R; Tota, S, 2010)
" However, the probable role of this drug in aluminum chloride (AlCl3)-induced experimental dementia is yet to be explored."3.81Protective effect of a calcium channel blocker "diltiazem" on aluminum chloride-induced dementia in mice. ( Kaur, A; Rani, A; Sodhi, RK, 2015)
"These findings suggest the antidementia activity of caffeic acid against AlCl3 -induced dementia in rats."3.79Impact of caffeic acid on aluminium chloride-induced dementia in rats. ( Khan, KA; Krishnadas, N; Kumar, N; Mudgal, J; Nampoothiri, M; Nayak, PG; Rao, CM; Shenoy, RR, 2013)
" Furthermore, we evaluated the effect of anti-dementia drugs memantine, a NMDA antagonist, and donepezil, a cholinesterase inhibitor, on OKA ICV induced memory impairment."3.76Okadaic acid (ICV) induced memory impairment in rats: a suitable experimental model to test anti-dementia activity. ( Kamat, PK; Nath, C; Saxena, G; Shukla, R; Tota, S, 2010)
"Dementia is a significant public health priority with approximately 55 million cases worldwide, and this number is predicted to quadruple by 2050."2.82Dietary nitrate and brain health. Too much ado about nothing or a solution for dementia prevention? ( Alharbi, M; Babateen, A; Shannon, O; Siervo, M; Stephan, B, 2022)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's2 (15.38)29.6817
2010's8 (61.54)24.3611
2020's2 (15.38)2.80

Authors

AuthorsStudies
Siervo, M1
Babateen, A1
Alharbi, M1
Stephan, B1
Shannon, O1
Carballo-Casla, A1
Dunk, MM1
Donat-Vargas, C1
Xu, W1
Khan, KA1
Kumar, N1
Nayak, PG1
Nampoothiri, M1
Shenoy, RR1
Krishnadas, N1
Rao, CM1
Mudgal, J1
Singh, G1
Sharma, B2
Jaggi, AS2
Singh, N2
Kumar, A2
Sodhi, RK3
Kaur, P1
Rani, A1
Kaur, A1
Deshmukh, R1
Kaundal, M1
Bansal, V1
Jain, S1
Tiwari, V1
Kuhad, A1
Bishnoi, M1
Chopra, K1
Kamat, PK1
Tota, S1
Saxena, G1
Shukla, R1
Nath, C1
Prakash, AK1
Kuiper, MA1
Visser, JJ1
Bergmans, PL1
Scheltens, P1
Wolters, EC1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Testing the Combined Effect of Dietary Nitrate and Caloric Restriction on Cognitive and Vascular Function in Older Adults Living With Overweight or Obesity: A 28-Day Pilot Randomised Trial[NCT06151015]20 participants (Anticipated)Interventional2024-01-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for nitrites and Dementia

ArticleYear
Dietary nitrate and brain health. Too much ado about nothing or a solution for dementia prevention?
    The British journal of nutrition, 2022, 09-28, Volume: 128, Issue:6

    Topics: Brain; Cardiovascular Diseases; Dementia; Diet; Humans; Nitrates; Nitric Oxide; Nitrites

2022

Other Studies

12 other studies available for nitrites and Dementia

ArticleYear
Could dietary nitrate affect dementia development?
    The American journal of clinical nutrition, 2023, Volume: 118, Issue:2

    Topics: Dementia; Diet; Dietary Supplements; Humans; Nitrates; Nitrites

2023
Impact of caffeic acid on aluminium chloride-induced dementia in rats.
    The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:12

    Topics: Aluminum Chloride; Aluminum Compounds; Animals; Caffeic Acids; Chlorides; Cholinesterase Inhibitors;

2013
Efficacy of bosentan, a dual ETA and ETB endothelin receptor antagonist, in experimental diabetes induced vascular endothelial dysfunction and associated dementia in rats.
    Pharmacology, biochemistry, and behavior, 2014, Volume: 124

    Topics: Acetylcholinesterase; Animals; Blood Glucose; Bosentan; Brain; Dementia; Diabetes Mellitus, Experime

2014
Silymarin ameliorates memory deficits and neuropathological changes in mouse model of high-fat-diet-induced experimental dementia.
    Naunyn-Schmiedeberg's archives of pharmacology, 2014, Volume: 387, Issue:8

    Topics: Acetylcholinesterase; Animals; Body Weight; Brain; Cholesterol; Dementia; Diet, High-Fat; Disease Mo

2014
Memory recuperative potential of rifampicin in aluminum chloride-induced dementia: role of pregnane X receptors.
    Neuroscience, 2015, Mar-12, Volume: 288

    Topics: Acetylcholinesterase; Aluminum Chloride; Aluminum Compounds; Amyloid; Animals; Brain; Chlorides; Cog

2015
Protective effect of a calcium channel blocker "diltiazem" on aluminum chloride-induced dementia in mice.
    Naunyn-Schmiedeberg's archives of pharmacology, 2015, Volume: 388, Issue:11

    Topics: Acetylcholinesterase; Aluminum Chloride; Aluminum Compounds; Animals; Behavior, Animal; Brain; Calci

2015
Caffeic acid attenuates oxidative stress, learning and memory deficit in intra-cerebroventricular streptozotocin induced experimental dementia in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 81

    Topics: Acetylcholinesterase; Animals; Behavior, Animal; Biomarkers; Caffeic Acids; Dementia; Hippocampus; I

2016
Effect of ruthenium red, a ryanodine receptor antagonist in experimental diabetes induced vascular endothelial dysfunction and associated dementia in rats.
    Physiology & behavior, 2016, 10-01, Volume: 164, Issue:Pt A

    Topics: Animals; Aorta; Blood Glucose; Body Weight; Brain; Calcium Channel Blockers; Dementia; Diabetes Mell

2016
Chronic treatment with tocotrienol, an isoform of vitamin E, prevents intracerebroventricular streptozotocin-induced cognitive impairment and oxidative-nitrosative stress in rats.
    Pharmacology, biochemistry, and behavior, 2009, Volume: 93, Issue:2

    Topics: Acetylcholinesterase; alpha-Tocopherol; Animals; Antioxidants; Brain; Catalase; Cognition Disorders;

2009
Okadaic acid (ICV) induced memory impairment in rats: a suitable experimental model to test anti-dementia activity.
    Brain research, 2010, Jan-14, Volume: 1309

    Topics: Animals; Brain; Calcium Signaling; Cholinesterase Inhibitors; Dementia; Disease Models, Animal; Done

2010
Effect of chronic treatment of carvedilol on oxidative stress in an intracerebroventricular streptozotocin induced model of dementia in rats.
    The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:12

    Topics: Acetylcholinesterase; Animals; Antioxidants; Behavior, Animal; Brain; Carbazoles; Carvedilol; Catala

2009
Decreased cerebrospinal fluid nitrate levels in Parkinson's disease, Alzheimer's disease and multiple system atrophy patients.
    Journal of the neurological sciences, 1994, Volume: 121, Issue:1

    Topics: Aged; Alzheimer Disease; Atrophy; Dementia; Female; Humans; Male; Middle Aged; Nerve Degeneration; N

1994