nitrites has been researched along with Carcinoma, Epidermoid in 21 studies
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Head and Neck squamous cell carcinoma is a widespread cancer that responds poorly to anticancer treatments such as chemotherapy and radiotherapy." | 1.48 | Effects of Plasma Activated Medium on Head and Neck FaDu Cancerous Cells: Comparison of 3D and 2D Response. ( Chauvin, J; Judee, F; Merbahi, N; Vicendo, P, 2018) |
| "They were classified histologically as squamous cell carcinomas or adenosquamous carcinomas, or both." | 1.26 | Carcinoma of the esophagus of rabbits induced with N-methyl-benzylamine and sodium nitrite. ( Hirota, T; Ichimura, S; Iizuka, T; Itabashi, M; Kawachi, T, 1977) |
| "Lymphomas were seen only at the higher dose when the animals were were young, at the beginning of the test." | 1.26 | Large bowel carcinogenesis in mice and rats by several intrarectal doses of methylnitrosourea and negative effect of nitrite plus methylurea. ( Maronpot, RR; Narisawa, T; Weisburger, JH; Wong, CQ, 1976) |
| "A total of 16 had squamous carcinomas in the lung; 25 had tumors of the oropharynx, tongue, esophagus, and forestomach; and there were a few animals with tumors in the nasal cavity and trachea." | 1.25 | Tumor induction in rats by feeding heptamethyleneimine and nitrite in water. ( Lijinsky, W; Taylor, HW, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (47.62) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 7 (33.33) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chauvin, J | 1 |
| Judee, F | 1 |
| Merbahi, N | 1 |
| Vicendo, P | 1 |
| Tuan, BT | 1 |
| Visacri, MB | 1 |
| Amaral, LS | 1 |
| Baldini, D | 1 |
| Ferrari, GB | 1 |
| Quintanilha, JC | 1 |
| Pincinato, EC | 1 |
| Mazzola, PG | 1 |
| Lima, CS | 1 |
| Moriel, P | 1 |
| Fetz, V | 1 |
| Bier, C | 1 |
| Habtemichael, N | 1 |
| Schuon, R | 1 |
| Schweitzer, A | 1 |
| Kunkel, M | 1 |
| Engels, K | 1 |
| Kovács, AF | 1 |
| Schneider, S | 1 |
| Mann, W | 1 |
| Stauber, RH | 1 |
| Knauer, SK | 1 |
| Shang, ZJ | 1 |
| Li, JR | 1 |
| Li, ZB | 1 |
| Gallo, O | 1 |
| Schiavone, N | 1 |
| Papucci, L | 1 |
| Sardi, I | 1 |
| Magnelli, L | 1 |
| Franchi, A | 1 |
| Masini, E | 1 |
| Capaccioli, S | 1 |
| Engel, LS | 1 |
| Chow, WH | 1 |
| Vaughan, TL | 1 |
| Gammon, MD | 1 |
| Risch, HA | 1 |
| Stanford, JL | 1 |
| Schoenberg, JB | 1 |
| Mayne, ST | 1 |
| Dubrow, R | 1 |
| Rotterdam, H | 1 |
| West, AB | 1 |
| Blaser, M | 1 |
| Blot, WJ | 1 |
| Gail, MH | 1 |
| Fraumeni, JF | 1 |
| Chen, T | 1 |
| Hwang, H | 1 |
| Rose, ME | 1 |
| Nines, RG | 1 |
| Stoner, GD | 1 |
| Rasheed, MH | 2 |
| Beevi, SS | 2 |
| Geetha, A | 1 |
| Rajaraman, R | 1 |
| Bose, SJ | 1 |
| Weisburger, JH | 2 |
| Marquardt, H | 1 |
| Hirota, N | 1 |
| Mori, H | 1 |
| Williams, GM | 1 |
| Arias-Díaz, J | 1 |
| Vara, E | 1 |
| Torres-Melero, J | 1 |
| García, C | 1 |
| Baki, W | 1 |
| Ramírez-Armengol, JA | 1 |
| Balibrea, JL | 1 |
| Liu, R | 1 |
| Oberley, TD | 1 |
| Oberley, LW | 1 |
| Iizuka, T | 1 |
| Ichimura, S | 1 |
| Kawachi, T | 1 |
| Hirota, T | 1 |
| Itabashi, M | 1 |
| Taylor, HW | 2 |
| Lijinsky, W | 2 |
| Narisawa, T | 1 |
| Wong, CQ | 1 |
| Maronpot, RR | 1 |
| Tahira, T | 1 |
| Ohgaki, H | 1 |
| Wakabayashi, K | 1 |
| Nagao, M | 1 |
| Sugimura, T | 1 |
| Sander, J | 1 |
| Bürkle, G | 1 |
| Ungerer, O | 1 |
| Eisenbrand, G | 1 |
| Preussmann, R | 1 |
| Rustia, M | 1 |
| Snyder, C | 1 |
| Nettesheim, P | 1 |
| Lynch, HT | 1 |
| Kwers, DD | 1 |
| Krush, AJ | 1 |
| Sharp, EA | 1 |
| Swartz, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention[NCT01192204] | Phase 1/Phase 2 | 41 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The remaining oral dysplasia lesion will be inspected at each follow up appointment (every 10-14 days). Biopsies will be immediately conducted on patients with any indication of malignant transformation including indurated, rolled borders, nonhealing ulcers, etc. Accordingly, these patients will withdraw from the trial. Participants will also be monitored for any changes consistent with contact mucositis e.g. soreness and erythema at application site. Clinical photographs were taken for the patients records. Pre treatment and post treatment photographs, with a ruler in place, were used for accurate pre and post treatment size measurement. NOTE: if treatment is beneficial, lesional size will decrease which will be reflected as a negative number. (NCT01192204)
Timeframe: pretreatment and posttreatment (3 months treatment duration)
| Intervention | mm^2 (Mean) |
|---|---|
| 10% FBR Gel | -26.12 |
| Placebo Gel | 18.12 |
Laboratory experiments will be conducted to assess the effects of gel treatment on pre and post loss of heterozygosity (LOH) events at loci associated with tumor suppressor genes. (NCT01192204)
Timeframe: Before and after the 3 month treatment duration
| Intervention | LOH events (Mean) |
|---|---|
| 10% FBR Gel | 0.9 |
| Placebo Gel | 0.4 |
A hemisection of lesional tissue will be conducted before the 3 month treatment to establish a diagnosis and provide a pretreatment baseline for the experimental parameters. Anl excisional biopsy of the treatment site including any remaining residual lesional tissue (excision of oral dysplastic lesions is consistent with current standards of care) will be obtained after 3 months of treatment to provide a posttreatment diagnosis. The 0 to 8 histologic scale was:0=normal with or without hyperkeratosis BEST OUTCOME, 1=atypia, 2=mild dysplasia, 3=mild-moderate dysplasia, 4=moderate dysplasia,5=moderate-severe dysplasia,6=severe dysplasia, 7=carcinoma in situ, 8=invasive oral squamous cell carcinoma (WORST OUTCOME). (NCT01192204)
Timeframe: Before and after the 3 month treatment.
| Intervention | unit on histologic grade scale (Mean) | |
|---|---|---|
| Pretreatment | Posttreatment | |
| 10% FBR Gel | 2.36 | 1.9 |
| Placebo Gel | 2.83 | 2.58 |
21 other studies available for nitrites and Carcinoma, Epidermoid
| Article | Year |
|---|---|
Effects of Plasma Activated Medium on Head and Neck FaDu Cancerous Cells: Comparison of 3D and 2D Response.
Topics: Antineoplastic Agents; Atmospheric Pressure; Carcinoma, Squamous Cell; Cell Proliferation; Culture M | 2018 |
Effects of High-Dose Cisplatin Chemotherapy and Conventional Radiotherapy on Urinary Oxidative and Nitrosative Stress Biomarkers in Patients with Head and Neck Cancer.
Topics: Adult; Aged; Antineoplastic Agents; Biomarkers; Carcinoma, Squamous Cell; Cisplatin; Dose-Response R | 2016 |
Inducible NO synthase confers chemoresistance in head and neck cancer by modulating survivin.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Carcin | 2009 |
Effects of exogenous nitric oxide on oral squamous cell carcinoma: an in vitro study.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Death; Cell Nucleolus; Cell Nucleus | 2002 |
Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Cyclooxygenase 2; Down-Regulation; Female; Gene Expression Re | 2003 |
Population attributable risks of esophageal and gastric cancers.
Topics: Adenocarcinoma; Adult; Aged; Alcohol Drinking; Body Mass Index; Carcinoma, Squamous Cell; Cardia; Ca | 2003 |
Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun.
Topics: Animals; Body Weight; Carcinogens; Carcinoma, Squamous Cell; Cyclooxygenase 2; Diet; Dimethylnitrosa | 2006 |
Enhanced lipid peroxidation and nitric oxide products with deranged antioxidant status in patients with head and neck squamous cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; alpha-Tocopherol; Antioxidants; Ascorbic Acid; Carcinoma, Squamous C | 2007 |
Alleviation of oxidative and nitrosative stress following curative resection in patient with oral cavity cancer.
Topics: Adult; Ascorbic Acid; Carcinoma, Squamous Cell; Case-Control Studies; Female; Glutathione; Glutathio | 2007 |
Induction of cancer of the glandular stomach in rats by an extract of nitrite-treated fish.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinoma, Squamous Cell; Fishes; Male; Mutagens; Neoplasms, Exper | 1980 |
Nitrite/nitrate and cytokine levels in bronchoalveolar lavage fluid of lung cancer patients.
Topics: Bronchoalveolar Lavage Fluid; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Cyclic GMP; Cytokin | 1994 |
Effects of endothelial nitric oxide synthase gene expression on the tumor biology of human oral carcinoma SCC-25 cells.
Topics: Animals; Carcinoma, Squamous Cell; Cattle; Cell Division; Cell Membrane; Cytoplasm; Gene Expression | 1998 |
Carcinoma of the esophagus of rabbits induced with N-methyl-benzylamine and sodium nitrite.
Topics: Adenocarcinoma; Administration, Oral; Amines; Animals; Benzylamines; Carcinoma, Squamous Cell; Esoph | 1977 |
Tumor induction in rats by feeding heptamethyleneimine and nitrite in water.
Topics: Animals; Azocines; Carcinogens; Carcinoma, Squamous Cell; Esophageal Neoplasms; Female; Lung Neoplas | 1975 |
Large bowel carcinogenesis in mice and rats by several intrarectal doses of methylnitrosourea and negative effect of nitrite plus methylurea.
Topics: Adenocarcinoma; Adenoma; Animals; Carcinoma, Squamous Cell; Colonic Neoplasms; Dose-Response Relatio | 1976 |
The inhibitory effect of thioproline on carcinogenesis induced by N-benzylmethylamine and nitrite.
Topics: Animals; Benzylamines; Carcinoma, Squamous Cell; Male; Nitrites; Rats; Rats, Inbred F344; Stomach Ne | 1988 |
[Induction of malignant tumors in rats by simultaneous feeding of nitrite and secondary amines].
Topics: Animals; Body Weight; Carcinogens; Carcinoma, Squamous Cell; Chemical Phenomena; Chemistry; Cystaden | 1969 |
[The reaction of nitrite with pesticides. Formation, chemical properties and carcinogenic activity of the N-nitroso compound of the herbicide N-methyl-N'-(2-benzothiazolyl)-urea (benzthiazuron) (author's transl)].
Topics: Administration, Oral; Animals; Carcinogens; Carcinoma, Squamous Cell; Chemical Phenomena; Chemistry; | 1974 |
Multiple carcinogenic effects of the ethylnitrosourea precursors ethylurea and sodium nitrite in hamsters.
Topics: Age Factors; Animals; Carcinogens; Carcinoma, Squamous Cell; Cricetinae; Female; Liver Neoplasms; Ma | 1974 |
Malignant tumours of liver and lung in rats fed aminopyrine or heptamethyleneimine together with nitrite.
Topics: Administration, Oral; Aminopyrine; Animals; Azocines; Biotransformation; Carcinoma, Squamous Cell; D | 1973 |
Esophageal cancer in a midwestern community.
Topics: Aged; Alcoholism; Carcinogens; Carcinoma; Carcinoma, Squamous Cell; Esophageal Neoplasms; Female; Hu | 1971 |