nitrites has been researched along with Cancer of Esophagus in 38 studies
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "They were classified histologically as squamous cell carcinomas or adenosquamous carcinomas, or both." | 1.26 | Carcinoma of the esophagus of rabbits induced with N-methyl-benzylamine and sodium nitrite. ( Hirota, T; Ichimura, S; Iizuka, T; Itabashi, M; Kawachi, T, 1977) |
| "A total of 16 had squamous carcinomas in the lung; 25 had tumors of the oropharynx, tongue, esophagus, and forestomach; and there were a few animals with tumors in the nasal cavity and trachea." | 1.25 | Tumor induction in rats by feeding heptamethyleneimine and nitrite in water. ( Lijinsky, W; Taylor, HW, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (57.89) | 18.7374 |
| 1990's | 2 (5.26) | 18.2507 |
| 2000's | 8 (21.05) | 29.6817 |
| 2010's | 4 (10.53) | 24.3611 |
| 2020's | 2 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Kaviani, A | 1 |
| Khansari Nejad, N | 1 |
| Akour, A | 1 |
| AlMuhaissen, SA | 1 |
| Nusair, MB | 1 |
| Al-Tammemi, AB | 1 |
| Mahmoud, NN | 1 |
| Jalouqa, S | 1 |
| Alrawashdeh, MN | 1 |
| Shanahan, JP | 1 |
| Moore, CM | 1 |
| Kampf, JW | 1 |
| Szymczak, NK | 1 |
| Guo, J | 1 |
| Wang, H | 4 |
| Luo, Y | 1 |
| An, H | 1 |
| Zhang, Z | 4 |
| Liu, G | 1 |
| Li, J | 9 |
| Metcalfe, GD | 1 |
| Smith, TW | 1 |
| Hippler, M | 1 |
| Ayala Izurieta, JE | 1 |
| Márquez, CO | 1 |
| García, VJ | 1 |
| Jara Santillán, CA | 1 |
| Sisti, JM | 1 |
| Pasqualotto, N | 1 |
| Van Wittenberghe, S | 1 |
| Delegido, J | 1 |
| Kubo, Y | 1 |
| Kitagawa, Y | 1 |
| Miyazaki, T | 1 |
| Sohda, M | 1 |
| Yamaji, T | 1 |
| Sakai, M | 1 |
| Saeki, H | 1 |
| Nemoto, K | 1 |
| Oyama, T | 2 |
| Muto, M | 1 |
| Takeuchi, H | 1 |
| Toh, Y | 1 |
| Matsubara, H | 1 |
| Mano, M | 1 |
| Kono, K | 1 |
| Kato, K | 1 |
| Yoshida, M | 1 |
| Kawakubo, H | 1 |
| Booka, E | 1 |
| Yamatsuji, T | 1 |
| Kato, H | 1 |
| Ito, Y | 1 |
| Ishikawa, H | 1 |
| Ishihara, R | 1 |
| Tsushima, T | 1 |
| Kawachi, H | 1 |
| Kojima, T | 1 |
| Kuribayashi, S | 1 |
| Makino, T | 1 |
| Matsuda, S | 1 |
| Doki, Y | 1 |
| Ma, P | 1 |
| Tang, X | 1 |
| Zhang, L | 5 |
| Wang, X | 6 |
| Wang, W | 4 |
| Zhang, X | 7 |
| Wang, S | 2 |
| Zhou, N | 1 |
| Dodd, J | 1 |
| Jordan, R | 1 |
| Makhlina, M | 1 |
| Pesco Koplowitz, L | 1 |
| Koplowitz, B | 1 |
| Barnett, K | 1 |
| Yang, WH | 1 |
| Spana, C | 1 |
| Buchanan, SW | 1 |
| Mafa-Attoye, T | 1 |
| Dunfield, K | 1 |
| Thevathasan, NV | 1 |
| Isaac, ME | 1 |
| Wu, X | 4 |
| Huang, JW | 1 |
| Su, BK | 1 |
| Yuan, L | 1 |
| Zheng, WQ | 1 |
| Zhang, H | 3 |
| Zheng, YX | 1 |
| Zhu, W | 1 |
| Chou, PT | 1 |
| Manso, AP | 1 |
| De Morais, DC | 1 |
| Yamamoto, K | 1 |
| Owen, G | 1 |
| de Carvalho, RM | 1 |
| Palma-Dibb, RG | 1 |
| Brown, JC | 1 |
| Yang, S | 2 |
| Mire, EF | 1 |
| Miele, L | 1 |
| Ochoa, A | 1 |
| Zabaleta, J | 1 |
| Katzmarzyk, PT | 1 |
| Moi, CT | 1 |
| Bhowmick, S | 1 |
| Qureshi, M | 1 |
| Wang, K | 2 |
| Feng, B | 1 |
| Yang, Y | 4 |
| Chen, Y | 2 |
| Wang, Y | 9 |
| Yang, L | 2 |
| Jiang, K | 1 |
| James, TD | 1 |
| Chaturvedi, V | 1 |
| Postiglione, WM | 1 |
| Chakraborty, RD | 1 |
| Yu, B | 3 |
| Tabiś, W | 1 |
| Hameed, S | 1 |
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| Jacobson, A | 1 |
| Zhou, H | 2 |
| Greven, M | 1 |
| Ferry, VE | 1 |
| Leighton, C | 1 |
| Wu, F | 2 |
| Lei, H | 2 |
| Chen, G | 1 |
| Chen, C | 1 |
| Song, Y | 2 |
| Cao, Z | 1 |
| Zhang, C | 5 |
| Zhou, J | 1 |
| Lu, Y | 2 |
| Pappone, C | 1 |
| Santinelli, V | 1 |
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| Tondi, L | 1 |
| Ciconte, G | 1 |
| Manguso, F | 1 |
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| Karaoz, U | 1 |
| Yachimski, PS | 1 |
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| Nossa, CW | 1 |
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| Popoff, MR | 1 |
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| López, F | 1 |
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| Yan, Z | 1 |
| Zhou, L | 1 |
| Zhao, Y | 3 |
| Wang, J | 7 |
| Huang, L | 2 |
| Hu, K | 1 |
| Liu, H | 4 |
| Guo, Z | 1 |
| Huang, H | 4 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 1 |
| Zhou, X | 1 |
| Wang, B | 4 |
| Zhang, Q | 4 |
| Yao, Y | 3 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
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| Hara, M | 1 |
| Sunada, K | 1 |
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| Jiao, J | 3 |
| Gai, QY | 3 |
| Zang, YP | 2 |
| Niu, LL | 2 |
| Fu, YJ | 3 |
| Yao, LP | 1 |
| Qin, QP | 1 |
| Wang, ZY | 1 |
| Liu, J | 4 |
| Aleksic Sabo, V | 1 |
| Knezevic, P | 1 |
| Borges-Argáez, R | 1 |
| Chan-Balan, R | 1 |
| Cetina-Montejo, L | 1 |
| Ayora-Talavera, G | 1 |
| Sansores-Peraza, P | 1 |
| Gómez-Carballo, J | 1 |
| Cáceres-Farfán, M | 1 |
| Jang, J | 1 |
| Akin, D | 1 |
| Bashir, R | 1 |
| Yu, Z | 1 |
| Zhu, J | 2 |
| Jiang, H | 1 |
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| Xiao, Z | 1 |
| Xu, J | 2 |
| Sun, Q | 1 |
| Han, D | 1 |
| Zhao, K | 2 |
| Zhu, L | 1 |
| Li, X | 4 |
| Fu, H | 2 |
| Wilson, BK | 1 |
| Step, DL | 1 |
| Maxwell, CL | 1 |
| Gifford, CA | 1 |
| Richards, CJ | 1 |
| Krehbiel, CR | 1 |
| Warner, JM | 1 |
| Doerr, AJ | 1 |
| Erickson, GE | 1 |
| Guretzky, JA | 1 |
| Rasby, RJ | 1 |
| Watson, AK | 1 |
| Klopfenstein, TJ | 1 |
| Sun, Y | 4 |
| Liu, Z | 3 |
| Pham, TD | 1 |
| Lee, BK | 1 |
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| Lin, L | 3 |
| Shao, J | 1 |
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| Liu, S | 1 |
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| Yang, Q | 1 |
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| Yu, Y | 2 |
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| Yang, X | 1 |
| Li, W | 3 |
| Wang, T | 2 |
| Campbell, DA | 1 |
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| Li, H | 5 |
| Yao, L | 2 |
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| Lee, JH | 2 |
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| Lee, EJ | 1 |
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| Delorme, M | 1 |
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| Lellouche, F | 1 |
| D'Urzo, KA | 1 |
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| D'Urzo, AD | 1 |
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| Macha, SJ | 1 |
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| Yazdani, V | 1 |
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| Hartley, AM | 2 |
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| Xu, JY | 1 |
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| Quigg, A | 1 |
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| Xu, W | 2 |
| Gao, S | 1 |
| Zhai, X | 1 |
| Wang, C | 3 |
| Gilson, E | 1 |
| Ye, J | 1 |
| Yan, R | 1 |
| Zhang, Y | 6 |
| Hu, Z | 1 |
| You, Q | 1 |
| Cai, Q | 1 |
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| Wu, PK | 1 |
| Hong, SK | 1 |
| Starenki, D | 1 |
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| Shao, H | 1 |
| Gestwicki, JE | 1 |
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| Park, JI | 1 |
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| Dong, C | 2 |
| Guo, G | 1 |
| Li, L | 4 |
| Barrett, HE | 1 |
| Meester, EJ | 1 |
| van Gaalen, K | 1 |
| van der Heiden, K | 1 |
| Krenning, BJ | 1 |
| Beekman, FJ | 1 |
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| Rigol, M | 1 |
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| Lobo, M | 1 |
| Mateo, J | 1 |
| Vilchez-Tschischke, JP | 1 |
| Salinas, B | 1 |
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| López, GJ | 1 |
| Fuster, V | 1 |
| Desco, M | 1 |
| Sanchez-González, J | 1 |
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| van den Berg, P | 1 |
| Schweitzer, DH | 1 |
| van Haard, PMM | 1 |
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| van den Bergh, JP | 1 |
| Zhu, X | 1 |
| Huang, X | 2 |
| Xu, H | 2 |
| Yang, G | 2 |
| Lin, Z | 1 |
| Salem, HF | 1 |
| Nafady, MM | 1 |
| Kharshoum, RM | 1 |
| Abd El-Ghafar, OA | 1 |
| Farouk, HO | 1 |
| Domiciano, D | 1 |
| Nery, FC | 1 |
| de Carvalho, PA | 1 |
| Prudente, DO | 1 |
| de Souza, LB | 1 |
| Chalfun-Júnior, A | 1 |
| Paiva, R | 1 |
| Marchiori, PER | 1 |
| Lu, M | 2 |
| An, Z | 1 |
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| Du, S | 1 |
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| Liu, Y | 7 |
| Song, J | 1 |
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| Gallo, AA | 1 |
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| Yang, TWW | 1 |
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| Yu, X | 2 |
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| Xie, Y | 2 |
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| Niu, PP | 1 |
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| Chen, D | 5 |
| Luo, K | 1 |
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| Zheng, G | 1 |
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| van Hest, JCM | 1 |
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| Shi, X | 1 |
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| Zhang, S | 2 |
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| Qi, N | 1 |
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| Zhao, W | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention[NCT01192204] | Phase 1/Phase 2 | 41 participants (Actual) | Interventional | 2010-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The remaining oral dysplasia lesion will be inspected at each follow up appointment (every 10-14 days). Biopsies will be immediately conducted on patients with any indication of malignant transformation including indurated, rolled borders, nonhealing ulcers, etc. Accordingly, these patients will withdraw from the trial. Participants will also be monitored for any changes consistent with contact mucositis e.g. soreness and erythema at application site. Clinical photographs were taken for the patients records. Pre treatment and post treatment photographs, with a ruler in place, were used for accurate pre and post treatment size measurement. NOTE: if treatment is beneficial, lesional size will decrease which will be reflected as a negative number. (NCT01192204)
Timeframe: pretreatment and posttreatment (3 months treatment duration)
| Intervention | mm^2 (Mean) |
|---|---|
| 10% FBR Gel | -26.12 |
| Placebo Gel | 18.12 |
Laboratory experiments will be conducted to assess the effects of gel treatment on pre and post loss of heterozygosity (LOH) events at loci associated with tumor suppressor genes. (NCT01192204)
Timeframe: Before and after the 3 month treatment duration
| Intervention | LOH events (Mean) |
|---|---|
| 10% FBR Gel | 0.9 |
| Placebo Gel | 0.4 |
A hemisection of lesional tissue will be conducted before the 3 month treatment to establish a diagnosis and provide a pretreatment baseline for the experimental parameters. Anl excisional biopsy of the treatment site including any remaining residual lesional tissue (excision of oral dysplastic lesions is consistent with current standards of care) will be obtained after 3 months of treatment to provide a posttreatment diagnosis. The 0 to 8 histologic scale was:0=normal with or without hyperkeratosis BEST OUTCOME, 1=atypia, 2=mild dysplasia, 3=mild-moderate dysplasia, 4=moderate dysplasia,5=moderate-severe dysplasia,6=severe dysplasia, 7=carcinoma in situ, 8=invasive oral squamous cell carcinoma (WORST OUTCOME). (NCT01192204)
Timeframe: Before and after the 3 month treatment.
| Intervention | unit on histologic grade scale (Mean) | |
|---|---|---|
| Pretreatment | Posttreatment | |
| 10% FBR Gel | 2.36 | 1.9 |
| Placebo Gel | 2.83 | 2.58 |
9 reviews available for nitrites and Cancer of Esophagus
| Article | Year |
|---|---|
Topics: Adult; Alcohol Drinking; Ammonia; Animals; Anti-Inflammatory Agents; Area Under Curve; B-Lymphocytes | 2021 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
When saliva meets acid: chemical warfare at the oesophagogastric junction.
Topics: Adenocarcinoma; Esophageal Neoplasms; Esophagogastric Junction; Gastric Acid; Gastroesophageal Reflu | 2005 |
Gastric carditis: Is it a histological response to high concentrations of luminal nitric oxide?
Topics: Adenocarcinoma; Cardia; Disease Progression; Esophageal Neoplasms; Esophagogastric Junction; Humans; | 2006 |
Nutritional modulation of cancer.
Topics: Animals; Carcinogens; Colonic Neoplasms; Diet; Esophageal Neoplasms; Female; Humans; Liver Neoplasms | 1980 |
[Carcinogenic N-nitroso compounds. Health aspects].
Topics: Air Pollution; Amines; Animals; Carcinogens; Esophageal Neoplasms; Food Analysis; Humans; Liver Neop | 1975 |
Role of fat, fiber, nitrate, and food additives in carcinogenesis: a critical evaluation and recommendations.
Topics: Animals; Carcinogens; Diet; Dietary Fats; Dietary Fiber; Esophageal Neoplasms; Food Additives; Human | 1986 |
Causes of gastric and esophageal cancer. Possible approach to prevention by vitamin C.
Topics: Alcohol Drinking; Animals; Ascorbic Acid; Cerebrovascular Disorders; Colonic Neoplasms; Diet; Esopha | 1985 |
Toxicity of nitrosamines: their possible human health hazards.
Topics: Abnormalities, Drug-Induced; Africa; Age Factors; Animal Feed; Animals; Brain Neoplasms; Carcinogens | 1971 |
1 trial available for nitrites and Cancer of Esophagus
29 other studies available for nitrites and Cancer of Esophagus
| Article | Year |
|---|---|
Progressive dysbiosis of human orodigestive microbiota along the sequence of gastroesophageal reflux, Barrett's esophagus and esophageal adenocarcinoma.
Topics: Acetaldehyde; Adenocarcinoma; Anti-Bacterial Agents; Barrett Esophagus; Case-Control Studies; Dysbio | 2022 |
Determination of dietary nitrite in patients with esophageal pre-cancerous lesion and normal people: a duplicate diet study.
Topics: Adult; Aged; Case-Control Studies; Diet; Diet Surveys; Esophageal Neoplasms; Female; Humans; Male; M | 2018 |
Dopant titrating ion mobility spectrometry for trace exhaled nitric oxide detection.
Topics: Adult; Anions; Benzoquinones; Biomarkers; Breath Tests; Carcinoma; Esophageal Neoplasms; Exhalation; | 2015 |
Dietary N-nitroso compounds, endogenous nitrosation, and the risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study.
Topics: Aged; Ascorbic Acid; Chlorophyll; Diet; Dimethylnitrosamine; Esophageal Neoplasms; Female; Follow-Up | 2013 |
Novel mechanism of nitrosative stress from dietary nitrate with relevance to gastro-oesophageal junction cancers.
Topics: Ascorbic Acid; Cell Membrane; Diet; Dose-Response Relationship, Drug; Epithelium; Esophageal Neoplas | 2003 |
Population attributable risks of esophageal and gastric cancers.
Topics: Adenocarcinoma; Adult; Aged; Alcohol Drinking; Body Mass Index; Carcinoma, Squamous Cell; Cardia; Ca | 2003 |
Dietary nitrate and nitrite levels in an endemic upper gastrointestinal (esophageal and gastric) cancer region of Turkey.
Topics: Age Distribution; Cohort Studies; Diet; Endemic Diseases; Esophageal Neoplasms; Female; Gastrointest | 2003 |
Nitrate and nitrosative chemistry within Barrett's oesophagus during acid reflux.
Topics: Aged; Ascorbic Acid; Barrett Esophagus; Esophageal Neoplasms; Esophagoscopy; Female; Gastroesophagea | 2005 |
Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun.
Topics: Animals; Body Weight; Carcinogens; Carcinoma, Squamous Cell; Cyclooxygenase 2; Diet; Dimethylnitrosa | 2006 |
Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms.
Topics: Animals; Anticarcinogenic Agents; Cyclooxygenase 2; Diet; Dimethylnitrosamine; Dinoprostone; DNA Add | 2006 |
Zinc deficiency and the development of esophageal and forestomach tumors in Sprague-Dawley rats fed precursors of N-nitroso-N-benzylmethylamine.
Topics: Animals; Benzylamines; Biotransformation; Dimethylnitrosamine; Esophageal Neoplasms; Male; Nitrites; | 1984 |
Zinc deficiency and the induction of oesophageal tumors in rats by benzylmethylamine and sodium nitrite.
Topics: Amines; Animals; Benzylamines; Carcinogens; Dimethylnitrosamine; Esophageal Neoplasms; Male; Neoplas | 1982 |
The microflora of the postoperative stomach.
Topics: Anemia, Pernicious; Bacteria; Esophageal Neoplasms; Gastric Juice; Humans; Hydrogen-Ion Concentratio | 1981 |
Tumours induced in Fischer 344 rats by the feeding of disulfiram together with sodium nitrite.
Topics: Animals; Carcinogens; Diet; Diethylnitrosamine; Disulfiram; Drug Interactions; Esophageal Neoplasms; | 1980 |
Nitrate and nitrite in saliva.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Cold Temperature; Esophageal Neoplasms; Fol | 1980 |
[Determination of nitrates and nitrites in well water from Yaocun commune, Linxien County, Henan province (author's transl)].
Topics: China; Esophageal Neoplasms; Humans; Nitrates; Nitrites; Seasons; Water Supply | 1979 |
Carcinoma of the esophagus of rabbits induced with N-methyl-benzylamine and sodium nitrite.
Topics: Adenocarcinoma; Administration, Oral; Amines; Animals; Benzylamines; Carcinoma, Squamous Cell; Esoph | 1977 |
Nitrite studies in oesophageal cancer.
Topics: Adult; Aged; Diet; Esophageal Neoplasms; Female; Gastric Juice; Humans; Male; Middle Aged; Nitrates; | 1978 |
Experimental tumors in digestive organs.
Topics: Animals; Azoxymethane; Benz(a)Anthracenes; Colonic Neoplasms; Cricetinae; Dogs; Duodenal Neoplasms; | 1976 |
Diet and gastrointestinal cancer.
Topics: Alcoholism; Animals; Colonic Neoplasms; Diet; Dietary Carbohydrates; Dietary Fats; Esophageal Neopla | 1976 |
Tumor induction in rats by feeding heptamethyleneimine and nitrite in water.
Topics: Animals; Azocines; Carcinogens; Carcinoma, Squamous Cell; Esophageal Neoplasms; Female; Lung Neoplas | 1975 |
Salivary nitrate and nitrite concentrations from a sample population of children and adults in high risk area for esophageal and gastric cancers in Kashmir, India.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Diet; Esophageal Neoplasms; Humans; India; | 1992 |
[Studies of pickled vegetables and cause of esophageal cancer in Linxian. II. Determination of nitrosamines and their precursors].
Topics: Diethylnitrosamine; Dimethylnitrosamine; Esophageal Neoplasms; Food Preservation; Humans; Nitrates; | 1991 |
Nitrite: a co-carcinogen?
Topics: Animals; Cocarcinogenesis; Dimethylnitrosamine; Drug Synergism; Esophageal Neoplasms; Female; Neopla | 1985 |
[Induction of malignant tumors in rats by simultaneous feeding of nitrite and secondary amines].
Topics: Animals; Body Weight; Carcinogens; Carcinoma, Squamous Cell; Chemical Phenomena; Chemistry; Cystaden | 1969 |
[Further experiments on the induction of tumors by oral administration of low dosages of N-methylbenzylamine and sodium nitrite].
Topics: Administration, Oral; Amines; Animals; Benzene Derivatives; Benzyl Compounds; Esophageal Neoplasms; | 1971 |
Malignant tumours of liver and lung in rats fed aminopyrine or heptamethyleneimine together with nitrite.
Topics: Administration, Oral; Aminopyrine; Animals; Azocines; Biotransformation; Carcinoma, Squamous Cell; D | 1973 |
[Formation of carcinogenic nitroso-compounds in the stomach of experimental animals and their significance for man. 1].
Topics: Adenoma; Amines; Aniline Compounds; Animals; Carcinogens; Carcinoma; Esophageal Neoplasms; Female; G | 1971 |
Esophageal cancer in a midwestern community.
Topics: Aged; Alcoholism; Carcinogens; Carcinoma; Carcinoma, Squamous Cell; Esophageal Neoplasms; Female; Hu | 1971 |