nitrites has been researched along with Brain Ischemia in 49 studies
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nitrites and BDNF may represent potential biomarkers for cortisol negative effects on the area of cerebral ischemia and penumbra, potentiating ischemic cell damage." | 7.85 | Potential Biomarkers with Plasma Cortisol, Brain-derived Neurotrophic Factor and Nitrites in Patients with Acute Ischemic Stroke. ( Casas, S; De Nicola, AF; Folgueira, A; Gargiulo-Monachelli, GM; Gonzalez Deniselle, MC; Lopez, J; Mattiazzi, M; Perez, AF, 2017) |
| "Melatonin at 60 min post ischemia rendered neuroprotection as evident by reduction in cerebral infarct volume, improvement in motor and neurological deficit and reduction in brain edema." | 7.80 | Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia. ( Bhattacharya, P; Pandey, AK; Patnaik, R; Paul, S, 2014) |
| "Findings of the present study provide significant evidence that Piroxicam acts as a potent AQP4 regulator and renders neuroprotection in focal cerebral ischemia." | 7.79 | Aquaporin-4 inhibition mediates piroxicam-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rodents. ( Bhattacharya, P; Pandey, AK; Patnaik, R; Paul, S; Yavagal, DR, 2013) |
| "Treatment of Valsartan attenuated cerebral injury, potentiated the neuroprotective response of iPoCo in normal rats, and also restored the blunted neuroprotective effect of iPoCo in HFD-treated rats along with enhanced Nrf-2 levels." | 5.91 | Valsartan Protects in High Fat Diet During Ischemic Reperfusion Injury. ( Jaggi, AS; Kaur, S; Kumar, K; Singh, N, 2023) |
| "Valproic acid (VA) is an antiepileptic that is also used for the treatment of bipolar disorders." | 5.48 | Neuroprotective effects of valproic acid on brain ischemia are related to its HDAC and GSK3 inhibitions. ( Correia, AO; Costa, RO; da Silva Ribeiro, AE; de Barros Viana, GS; de Siqueira, KP; Dos Santos, GCA; Lima, DGS; Lucetti, DL; Lucetti, ECP; Moura, JA; Neves, KRT; Parente, LLT; Silva, MR, 2018) |
| "Nitrites and BDNF may represent potential biomarkers for cortisol negative effects on the area of cerebral ischemia and penumbra, potentiating ischemic cell damage." | 3.85 | Potential Biomarkers with Plasma Cortisol, Brain-derived Neurotrophic Factor and Nitrites in Patients with Acute Ischemic Stroke. ( Casas, S; De Nicola, AF; Folgueira, A; Gargiulo-Monachelli, GM; Gonzalez Deniselle, MC; Lopez, J; Mattiazzi, M; Perez, AF, 2017) |
| "Candesartan has been reported to have a protective effect on cerebral ischemia in vivo and in human ischemic stroke." | 3.81 | Candesartan improves ischemia-induced impairment of the blood-brain barrier in vitro. ( Deli, MA; Hayashi, K; Hiu, T; Matsuo, T; Morofuji, Y; Nagata, I; Nakagawa, S; Niwa, M; So, G; Suyama, K; Tanaka, K, 2015) |
| "Melatonin at 60 min post ischemia rendered neuroprotection as evident by reduction in cerebral infarct volume, improvement in motor and neurological deficit and reduction in brain edema." | 3.80 | Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia. ( Bhattacharya, P; Pandey, AK; Patnaik, R; Paul, S, 2014) |
| "Findings of the present study provide significant evidence that Piroxicam acts as a potent AQP4 regulator and renders neuroprotection in focal cerebral ischemia." | 3.79 | Aquaporin-4 inhibition mediates piroxicam-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rodents. ( Bhattacharya, P; Pandey, AK; Patnaik, R; Paul, S; Yavagal, DR, 2013) |
| " Methylene blue exerted neuroprotective effects against the brain damage associated with the ischemia/reperfusion injury and ameliorated the blood-brain barrier disruption by decreasing nitric oxide metabolites." | 3.76 | Methylene blue protects the cortical blood-brain barrier against ischemia/reperfusion-induced disruptions. ( Martijn, C; Miclescu, A; Sharma, HS; Wiklund, L, 2010) |
| "Daily intake of green tea catechins efficiently protects the penumbra from irreversible damage due to cerebral ischemia, and consequent neurologic deficits." | 3.72 | Protective effects of green tea catechins on cerebral ischemic damage. ( Ikeda, M; Suzuki, M; Tabuchi, M; Tomita, T; Umegaki, K, 2004) |
| "Treatment of Valsartan attenuated cerebral injury, potentiated the neuroprotective response of iPoCo in normal rats, and also restored the blunted neuroprotective effect of iPoCo in HFD-treated rats along with enhanced Nrf-2 levels." | 1.91 | Valsartan Protects in High Fat Diet During Ischemic Reperfusion Injury. ( Jaggi, AS; Kaur, S; Kumar, K; Singh, N, 2023) |
| "Valproic acid (VA) is an antiepileptic that is also used for the treatment of bipolar disorders." | 1.48 | Neuroprotective effects of valproic acid on brain ischemia are related to its HDAC and GSK3 inhibitions. ( Correia, AO; Costa, RO; da Silva Ribeiro, AE; de Barros Viana, GS; de Siqueira, KP; Dos Santos, GCA; Lima, DGS; Lucetti, DL; Lucetti, ECP; Moura, JA; Neves, KRT; Parente, LLT; Silva, MR, 2018) |
| " In this clinical study, we investigated whether PD-mediated impairment of nitric oxide (NO) bioavailability and signaling, in patients with persistently low systolic blood pressure (SBP), can explain the occurrence of cerebral ischemia." | 1.43 | Peritoneal dialysis impairs nitric oxide homeostasis and may predispose infants with low systolic blood pressure to cerebral ischemia. ( Bárány, P; Békássy, Z; Cananau, C; Carlström, M; Checa, A; Hansson, S; Krmar, RT; Lundberg, JO; Sartz, L; Svensson, A; Weitzberg, E; Westphal, S; Wheelock, CE; Wide, K, 2016) |
| "Ischaemic stroke has become one of the leading causes of death and disability worldwide." | 1.43 | Suppression of ischaemia-induced injuries in rat brain by protease-activated receptor-1 (PAR-1) activating peptide. ( Lam, FFY; Ng, ESK; Zhen, X, 2016) |
| " The present study aims to determine the effect of short term (seven-days) administration of high dosage grape seed and skin extract (GSSE 2." | 1.42 | Protective effect of grape seed and skin extract on cerebral ischemia in rat: implication of transition metals. ( Ezzedine, A; Ferid, L; Meherzia, M; Mohamed, A; Mohamed, E; Pascal, C; Safwen, K; Selima, S, 2015) |
| "The neuronal damage following cerebral ischemia is a serious risk to stroke patients." | 1.37 | Protective effects of alkaloid extract from Leonurus heterophyllus on cerebral ischemia reperfusion injury by middle cerebral ischemic injury (MCAO) in rats. ( Ji, A; Liang, H; Liu, P; Song, S; Wang, Y, 2011) |
| "Increased duration of cerebral ischemia resulted in a progressive induction of oxidative stress." | 1.36 | MK-801 effect on regional cerebral oxidative stress rate induced by different duration of global ischemia in gerbils. ( Janac, B; Radenovic, L; Selakovic, V, 2010) |
| "Focal cerebral ischemia was induced in two sets of animals by permanent middle cerebral artery occlusion." | 1.35 | The protective effect of dexanabinol (HU-211) on nitric oxide and cysteine protease-mediated neuronal death in focal cerebral ischemia. ( Aral, E; Arslan, OC; Durmaz, R; Kanbak, G; Kartkaya, K; Ozden, H; Uzuner, K, 2008) |
| "We concluded that curcumin ameliorates cerebral ischemia/reperfusion injury by preventing ONOO(-) mediated blood-brain barrier damage." | 1.34 | Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage. ( Hu, M; Jiang, J; Li, F; Sun, YJ; Wang, W; Zhu, DY, 2007) |
| "Focal cerebral ischemia in rats was produced by permanent occlusion of right middle cerebral artery (MCAO)." | 1.33 | Effects of MK-801 on nitrite and cGMP levels during focal cerebral ischemia in rats. ( Balkan, E; Balkan, S; Gümüslü, S; Ozben, T; Serteser, M, 2005) |
| "Forebrain ischemia was induced for 30 min by occlusion of the bilateral common carotid arteries without hemorrhagic hypotension." | 1.31 | Severe cerebral blood flow reduction inhibits nitric oxide synthesis. ( Fujisawa, H; Shima, H; Suzuki, M; Uetsuka, S; Yasuda, H, 2002) |
| "Melatonin treatment increased survival and reduced hyperactivity linked to neurodegeneration induced by cerebral ischemia and reperfusion." | 1.31 | Protective effects of melatonin in ischemic brain injury. ( Barberi, I; Caputi, AP; Cordaro, S; Costantino, G; Cuzzocrea, S; De Sarro, A; Fulia, F; Gitto, E; Mazzon, E; Serraino, I, 2000) |
| "Focal cerebral ischemia was produced by permanent occlusion of right MCA in urethane anesthetized rats." | 1.30 | The effects of nitric oxide synthase inhibitor, L-NAME on NO production during focal cerebral ischemia in rats: could L-NAME be the future treatment of sudden deafness? ( Balkan, E; Balkan, S; Gümüslü, S; Oguz, N; Ozben, T; Serteser, M, 1997) |
| "Compared to sham-operated controls, cerebral ischemia-reperfusion resulted in a significant increase in total and inducible NOS activity and a significant increase in the production of NO and superoxide in the cerebral hemispheres." | 1.30 | Augmentation of nitric oxide, superoxide, and peroxynitrite production during cerebral ischemia and reperfusion in the rat. ( Forman, LJ; Liu, P; Nagele, RG; Wong, PY; Yin, K, 1998) |
| "Rats were subjected to global cerebral ischemia produced by occlusion of both common carotid arteries together with induced hypotension." | 1.29 | Brain nitrite production during global ischemia and reperfusion: an in vivo microdialysis study. ( Araki, N; Fukuuchi, Y; Hamada, J; Sasaki, T; Shibata, M; Shimazu, K, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (10.20) | 18.2507 |
| 2000's | 21 (42.86) | 29.6817 |
| 2010's | 21 (42.86) | 24.3611 |
| 2020's | 2 (4.08) | 2.80 |
| Authors | Studies |
|---|---|
| Kaur, S | 1 |
| Kumar, K | 1 |
| Singh, N | 1 |
| Jaggi, AS | 1 |
| Silver, JH | 1 |
| Jaffe, RA | 1 |
| López, JR | 1 |
| Casas, S | 1 |
| Perez, AF | 1 |
| Mattiazzi, M | 1 |
| Lopez, J | 1 |
| Folgueira, A | 1 |
| Gargiulo-Monachelli, GM | 1 |
| Gonzalez Deniselle, MC | 1 |
| De Nicola, AF | 1 |
| Silva, MR | 1 |
| Correia, AO | 1 |
| Dos Santos, GCA | 1 |
| Parente, LLT | 1 |
| de Siqueira, KP | 1 |
| Lima, DGS | 1 |
| Moura, JA | 1 |
| da Silva Ribeiro, AE | 1 |
| Costa, RO | 1 |
| Lucetti, DL | 1 |
| Lucetti, ECP | 1 |
| Neves, KRT | 1 |
| de Barros Viana, GS | 1 |
| Bhattacharya, P | 2 |
| Pandey, AK | 2 |
| Paul, S | 2 |
| Patnaik, R | 2 |
| Yavagal, DR | 1 |
| Safwen, K | 1 |
| Selima, S | 1 |
| Mohamed, E | 1 |
| Ferid, L | 1 |
| Pascal, C | 1 |
| Mohamed, A | 1 |
| Ezzedine, A | 1 |
| Meherzia, M | 1 |
| Gumanova, NG | 1 |
| Teplova, NV | 1 |
| Ryabchenko, AU | 1 |
| Denisov, EN | 1 |
| So, G | 1 |
| Nakagawa, S | 1 |
| Morofuji, Y | 1 |
| Hiu, T | 1 |
| Hayashi, K | 1 |
| Tanaka, K | 1 |
| Suyama, K | 1 |
| Deli, MA | 1 |
| Nagata, I | 1 |
| Matsuo, T | 1 |
| Niwa, M | 1 |
| Paspalj, D | 1 |
| Nikic, P | 1 |
| Savic, M | 1 |
| Djuric, D | 1 |
| Simanic, I | 1 |
| Zivkovic, V | 1 |
| Jeremic, N | 1 |
| Srejovic, I | 1 |
| Jakovljevic, V | 1 |
| Hess, DC | 1 |
| Hoda, MN | 1 |
| Khan, MB | 1 |
| Jin, YC | 1 |
| Lee, H | 1 |
| Kim, SW | 1 |
| Kim, ID | 1 |
| Lee, HK | 1 |
| Lee, Y | 1 |
| Han, PL | 1 |
| Lee, JK | 1 |
| Carlström, M | 1 |
| Cananau, C | 1 |
| Checa, A | 1 |
| Wide, K | 1 |
| Sartz, L | 1 |
| Svensson, A | 1 |
| Wheelock, CE | 1 |
| Westphal, S | 1 |
| Békássy, Z | 1 |
| Bárány, P | 1 |
| Lundberg, JO | 1 |
| Hansson, S | 1 |
| Weitzberg, E | 1 |
| Krmar, RT | 1 |
| Zhen, X | 1 |
| Ng, ESK | 1 |
| Lam, FFY | 1 |
| Kaur, J | 1 |
| Sharma, S | 2 |
| Sandhu, M | 1 |
| Fontes-Júnior, EA | 1 |
| Maia, CS | 1 |
| Fernandes, LM | 1 |
| Gomes-Leal, W | 1 |
| Costa-Malaquias, A | 1 |
| Lima, RR | 1 |
| Prediger, RD | 1 |
| Crespo-López, ME | 1 |
| Dohare, P | 1 |
| Garg, P | 1 |
| Jain, V | 1 |
| Nath, C | 1 |
| Ray, M | 1 |
| Moe, KT | 1 |
| Woon, FP | 1 |
| De Silva, DA | 1 |
| Wong, P | 1 |
| Koh, TH | 1 |
| Kingwell, B | 1 |
| Chin-Dusting, J | 1 |
| Wong, MC | 1 |
| Ito, Y | 1 |
| Ohkubo, T | 1 |
| Asano, Y | 1 |
| Hattori, K | 1 |
| Shimazu, T | 1 |
| Yamazato, M | 1 |
| Nagoya, H | 1 |
| Kato, Y | 1 |
| Araki, N | 2 |
| Selakovic, V | 2 |
| Janac, B | 1 |
| Radenovic, L | 2 |
| Yuan, Z | 1 |
| Liu, W | 1 |
| Liu, B | 1 |
| Schnell, A | 1 |
| Liu, KJ | 1 |
| Miclescu, A | 1 |
| Sharma, HS | 1 |
| Martijn, C | 1 |
| Wiklund, L | 1 |
| Jung, KH | 1 |
| Chu, K | 1 |
| Lee, ST | 1 |
| Sunwoo, JS | 1 |
| Park, DK | 1 |
| Kim, JH | 1 |
| Kim, S | 1 |
| Lee, SK | 1 |
| Kim, M | 1 |
| Roh, JK | 1 |
| Liang, H | 1 |
| Liu, P | 2 |
| Wang, Y | 1 |
| Song, S | 1 |
| Ji, A | 1 |
| Korenic, A | 1 |
| Ding-Zhou, L | 1 |
| Marchand-Verrecchia, C | 1 |
| Croci, N | 1 |
| Plotkine, M | 1 |
| Margaill, I | 1 |
| Uetsuka, S | 1 |
| Fujisawa, H | 1 |
| Yasuda, H | 1 |
| Shima, H | 1 |
| Suzuki, M | 2 |
| Temiz, C | 1 |
| Tun, K | 1 |
| Ugur, HC | 1 |
| Dempsey, RJ | 1 |
| Egemen, N | 1 |
| Hassan, A | 1 |
| Gormley, K | 1 |
| O'Sullivan, M | 1 |
| Knight, J | 1 |
| Sham, P | 1 |
| Vallance, P | 1 |
| Bamford, J | 1 |
| Markus, H | 1 |
| Maia, FD | 1 |
| Pitombeira, BS | 1 |
| Aráujo, DT | 1 |
| Cunha, GM | 2 |
| Viana, GS | 2 |
| Tabuchi, M | 1 |
| Ikeda, M | 1 |
| Umegaki, K | 1 |
| Tomita, T | 1 |
| Suk, K | 1 |
| Park, JH | 1 |
| Lee, WH | 1 |
| Galvão, RI | 1 |
| Diógenes, JP | 1 |
| Maia, GC | 1 |
| Filho, EA | 1 |
| Vasconcelos, SM | 1 |
| de Menezes, DB | 1 |
| Ozben, T | 2 |
| Balkan, E | 2 |
| Balkan, S | 2 |
| Serteser, M | 2 |
| Gümüslü, S | 2 |
| Hou, RC | 1 |
| Chen, YS | 1 |
| Chen, CH | 1 |
| Chen, YH | 1 |
| Jeng, KC | 1 |
| Xia, CF | 2 |
| Yin, H | 1 |
| Borlongan, CV | 2 |
| Chao, J | 2 |
| Chao, L | 2 |
| Smith, RS | 1 |
| Shen, B | 1 |
| Yang, ZR | 1 |
| Jiang, J | 1 |
| Wang, W | 1 |
| Sun, YJ | 1 |
| Hu, M | 1 |
| Li, F | 1 |
| Zhu, DY | 1 |
| Durmaz, R | 1 |
| Ozden, H | 1 |
| Kanbak, G | 1 |
| Aral, E | 1 |
| Arslan, OC | 1 |
| Kartkaya, K | 1 |
| Uzuner, K | 1 |
| Kumura, E | 2 |
| Kosaka, H | 2 |
| Shiga, T | 2 |
| Yoshimine, T | 2 |
| Hayakawa, T | 2 |
| Shibata, M | 1 |
| Hamada, J | 1 |
| Sasaki, T | 1 |
| Shimazu, K | 1 |
| Fukuuchi, Y | 1 |
| Takaoka, M | 1 |
| Oguz, N | 1 |
| Forman, LJ | 1 |
| Nagele, RG | 1 |
| Yin, K | 1 |
| Wong, PY | 1 |
| LeBlanc, MH | 1 |
| Feng, Y | 1 |
| Fratkin, JD | 1 |
| Calapai, G | 1 |
| Marciano, MC | 1 |
| Corica, F | 1 |
| Allegra, A | 1 |
| Parisi, A | 1 |
| Frisina, N | 1 |
| Caputi, AP | 2 |
| Buemi, M | 1 |
| Fassbender, K | 1 |
| Fatar, M | 1 |
| Ragoschke, A | 1 |
| Picard, M | 1 |
| Bertsch, T | 1 |
| Kuehl, S | 1 |
| Hennerici, M | 1 |
| Cuzzocrea, S | 1 |
| Costantino, G | 1 |
| Gitto, E | 1 |
| Mazzon, E | 1 |
| Fulia, F | 1 |
| Serraino, I | 1 |
| Cordaro, S | 1 |
| Barberi, I | 1 |
| De Sarro, A | 1 |
| Sakowitz, OW | 1 |
| Wolfrum, S | 1 |
| Sarrafzadeh, AS | 1 |
| Stover, JF | 1 |
| Dreier, JP | 1 |
| Dendorfer, A | 1 |
| Benndorf, G | 1 |
| Lanksch, WR | 1 |
| Unterberg, AW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Metabolism Research of KLK Treating Acute Cerebral Ischemic Stroke: Focus on Drug Frequency-Efficacy Relationship[NCT02806128] | 100 participants (Anticipated) | Interventional | 2016-11-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
49 other studies available for nitrites and Brain Ischemia
| Article | Year |
|---|---|
Valsartan Protects in High Fat Diet During Ischemic Reperfusion Injury.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Brain Ischemia; | 2023 |
Plasma nitrite as an indicator of cerebral ischemia during extracranial/intracranial bypass surgery in moyamoya patients.
Topics: Adult; Biomarkers; Brain Ischemia; Cerebral Revascularization; Cerebrovascular Circulation; Collater | 2020 |
Potential Biomarkers with Plasma Cortisol, Brain-derived Neurotrophic Factor and Nitrites in Patients with Acute Ischemic Stroke.
Topics: Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; Brain-Derived Neurotrophic Factor; Female; Huma | 2017 |
Neuroprotective effects of valproic acid on brain ischemia are related to its HDAC and GSK3 inhibitions.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Ischemia; Cyclooxygenase 2 Inhibitors; Dopamin | 2018 |
Aquaporin-4 inhibition mediates piroxicam-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rodents.
Topics: Animals; Aquaporin 4; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Calcium; Dose-Response R | 2013 |
Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia.
Topics: Animals; Antioxidants; Apoptosis; Aquaporin 4; Blotting, Western; Brain Edema; Brain Ischemia; Calci | 2014 |
Protective effect of grape seed and skin extract on cerebral ischemia in rat: implication of transition metals.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Calcium; Calpain; Cerebral Infarction; Female; Malondi | 2015 |
Serum nitrate and nitrite levels in patients with hypertension and ischemic stroke depend on diet: a multicenter study.
Topics: Adult; Aged; Aged, 80 and over; Brain Ischemia; Diet; Female; Humans; Hypertension; Male; Middle Age | 2015 |
Candesartan improves ischemia-induced impairment of the blood-brain barrier in vitro.
Topics: Animals; Benzimidazoles; Biphenyl Compounds; Blood-Brain Barrier; Brain Ischemia; Cell Survival; Ele | 2015 |
Redox status in acute ischemic stroke: correlation with clinical outcome.
Topics: Aged; Aged, 80 and over; Brain Ischemia; Catalase; Erythrocytes; Female; Humans; Hydrogen Peroxide; | 2015 |
Humoral Mediators of Remote Ischemic Conditioning: Important Role of eNOS/NO/Nitrite.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Chemokine CXCL12; Humans; Interleukin-10; Isch | 2016 |
Intranasal Delivery of RGD Motif-Containing Osteopontin Icosamer Confers Neuroprotection in the Postischemic Brain via αvβ3 Integrin Binding.
Topics: Administration, Intranasal; Amino Acid Sequence; Animals; Anti-Inflammatory Agents; Brain; Brain Isc | 2016 |
Peritoneal dialysis impairs nitric oxide homeostasis and may predispose infants with low systolic blood pressure to cerebral ischemia.
Topics: Arginine; Blood Pressure; Brain; Brain Ischemia; Cerebrovascular Circulation; Cyclic GMP; Female; Ho | 2016 |
Suppression of ischaemia-induced injuries in rat brain by protease-activated receptor-1 (PAR-1) activating peptide.
Topics: Amino Acid Sequence; Animals; Antioxidants; bcl-2-Associated X Protein; Brain; Brain Ischemia; Gene | 2016 |
Neurokinin-1 receptor inhibition reverses ischaemic brain injury and dementia in bilateral common carotid artery occluded rats: possible mechanisms.
Topics: Acetylcholinesterase; Animals; Aprepitant; Brain; Brain Ischemia; Carotid Stenosis; Dementia, Vascul | 2016 |
Chronic Alcohol Intoxication and Cortical Ischemia: Study of Their Comorbidity and the Protective Effects of Minocycline.
Topics: Alcoholic Intoxication; Animals; Behavior, Animal; Brain Ischemia; Disease Models, Animal; Endotheli | 2016 |
Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat.
Topics: Animals; Behavior, Animal; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Curcumin; Disea | 2008 |
Association of acute ischemic stroke with the MTHFR C677T polymorphism but not with NOS3 gene polymorphisms in a Singapore population.
Topics: Acute Disease; Asian People; Brain Ischemia; DNA Mutational Analysis; Female; Gene Frequency; Geneti | 2008 |
Nitric oxide production during cerebral ischemia and reperfusion in eNOS- and nNOS-knockout mice.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Cerebrovascular Circulation; Chromatography, High Pr | 2010 |
MK-801 effect on regional cerebral oxidative stress rate induced by different duration of global ischemia in gerbils.
Topics: Animals; Brain; Brain Ischemia; Carotid Artery, Common; Dizocilpine Maleate; Excitatory Amino Acid A | 2010 |
Normobaric hyperoxia delays and attenuates early nitric oxide production in focal cerebral ischemic rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Hyperoxia; Ischemic Attack, Transient; Male; Middle Ce | 2010 |
Methylene blue protects the cortical blood-brain barrier against ischemia/reperfusion-induced disruptions.
Topics: Animals; Blood-Brain Barrier; Blotting, Western; Brain Ischemia; Cardiopulmonary Resuscitation; Cere | 2010 |
Effects of long term nitrite therapy on functional recovery in experimental ischemia model.
Topics: Animals; Brain Ischemia; Caspases; Cytokines; Disease Models, Animal; Female; Humans; Neovasculariza | 2010 |
Protective effects of alkaloid extract from Leonurus heterophyllus on cerebral ischemia reperfusion injury by middle cerebral ischemic injury (MCAO) in rats.
Topics: Alkaloids; Animals; Apoptosis; Brain Ischemia; Infarction, Middle Cerebral Artery; Leonurus; Male; M | 2011 |
Spatial and temporal patterns of oxidative stress in the brain of gerbils submitted to different duration of global cerebral ischemia.
Topics: Animals; Brain; Brain Ischemia; Gerbillinae; Glutathione; Lipid Peroxidation; Male; Nitric Oxide; Ni | 2011 |
L-NAME reduces infarction, neurological deficit and blood-brain barrier disruption following cerebral ischemia in mice.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Brain Ischemia; Disease Models, Animal; Enzyme | 2002 |
Severe cerebral blood flow reduction inhibits nitric oxide synthesis.
Topics: Animals; Brain; Brain Ischemia; Carotid Arteries; Cerebrovascular Circulation; Enzyme Inhibitors; In | 2002 |
L-arginine in focal cerebral ischemia.
Topics: Animals; Arginine; Brain Edema; Brain Ischemia; Neuroprotective Agents; Nitrates; Nitric Oxide; Nitr | 2003 |
Endothelial nitric oxide gene haplotypes and risk of cerebral small-vessel disease.
Topics: Aged; Alleles; Brain; Brain Infarction; Brain Ischemia; Female; Gene Frequency; Genotype; Haplotypes | 2004 |
l-Deprenyl prevents lipid peroxidation and memory deficits produced by cerebral ischemia in rats.
Topics: Animals; Antioxidants; Avoidance Learning; Brain Ischemia; Disease Models, Animal; Dose-Response Rel | 2004 |
Protective effects of green tea catechins on cerebral ischemic damage.
Topics: Animals; Brain Ischemia; Catechin; Chromatography, High Pressure Liquid; Dose-Response Relationship, | 2004 |
Neuropeptide PACAP inhibits hypoxic activation of brain microglia: a protective mechanism against microglial neurotoxicity in ischemia.
Topics: Animals; Animals, Newborn; Blotting, Western; Brain Ischemia; Cell Survival; Cells, Cultured; Cocult | 2004 |
Tenoxicam exerts a neuroprotective action after cerebral ischemia in rats.
Topics: Animals; Brain; Brain Ischemia; Dose-Response Relationship, Drug; Male; Neuroprotective Agents; Nitr | 2005 |
Effects of MK-801 on nitrite and cGMP levels during focal cerebral ischemia in rats.
Topics: Animals; Brain; Brain Ischemia; Cyclic GMP; Disease Models, Animal; Dizocilpine Maleate; Male; Nitri | 2005 |
Protective effect of 1,2,4-benzenetriol on LPS-induced NO production by BV2 microglial cells.
Topics: Animals; Brain Ischemia; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Hyd | 2006 |
Postischemic infusion of adrenomedullin protects against ischemic stroke by inhibiting apoptosis and promoting angiogenesis.
Topics: Adrenomedullin; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; B | 2006 |
Postischemic brain injury is exacerbated in mice lacking the kinin B2 receptor.
Topics: Animals; Apoptosis; Brain; Brain Ischemia; Cerebral Infarction; Female; Glycogen Synthase Kinase 3; | 2006 |
Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage.
Topics: Animals; Astrocytes; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Capillaries; Curcuma; Curcumi | 2007 |
The protective effect of dexanabinol (HU-211) on nitric oxide and cysteine protease-mediated neuronal death in focal cerebral ischemia.
Topics: Animals; Brain Ischemia; Cathepsin B; Cathepsin L; Cathepsins; Cell Death; Cerebral Cortex; Cysteine | 2008 |
Elevation of plasma nitric oxide end products during focal cerebral ischemia and reperfusion in the rat.
Topics: Animals; Arginine; Blood Pressure; Brain Ischemia; Drug Combinations; Male; NG-Nitroarginine Methyl | 1994 |
Brain nitrite production during global ischemia and reperfusion: an in vivo microdialysis study.
Topics: Animals; Brain; Brain Ischemia; Enzyme Inhibitors; Male; Microdialysis; NG-Nitroarginine Methyl Este | 1996 |
Hypothermia suppresses nitric oxide elevation during reperfusion after focal cerebral ischemia in rats.
Topics: Animals; Body Temperature; Brain Ischemia; Hemoglobins; Hypothermia, Induced; Jugular Veins; Male; N | 1996 |
The effects of nitric oxide synthase inhibitor, L-NAME on NO production during focal cerebral ischemia in rats: could L-NAME be the future treatment of sudden deafness?
Topics: Animals; Brain Chemistry; Brain Ischemia; Cerebral Arteries; Cyclic GMP; Enzyme Inhibitors; Hearing | 1997 |
Augmentation of nitric oxide, superoxide, and peroxynitrite production during cerebral ischemia and reperfusion in the rat.
Topics: Animals; Brain Ischemia; Enzyme Induction; Immunohistochemistry; Leukocyte Count; Male; Nitrates; Ni | 1998 |
N-tosyl-L-phenylalanyl-chloromethylketone reduces hypoxic-ischemic brain injury in rat pups.
Topics: Animals; Animals, Newborn; Brain; Brain Ischemia; DNA; DNA Fragmentation; Dose-Response Relationship | 2000 |
Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation.
Topics: Aldehydes; Animals; Brain; Brain Edema; Brain Ischemia; Erythropoietin; Gerbillinae; Humans; Injecti | 2000 |
Subacute but not acute generation of nitric oxide in focal cerebral ischemia.
Topics: Animals; Brain Ischemia; Corpus Striatum; Enzyme Inhibitors; Guanidines; Microdialysis; Nerve Degene | 2000 |
Protective effects of melatonin in ischemic brain injury.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Enzyme-Linked Immunosorbent Assay; Free Radical Scaveng | 2000 |
Relation of cerebral energy metabolism and extracellular nitrite and nitrate concentrations in patients after aneurysmal subarachnoid hemorrhage.
Topics: Adult; Aged; Brain Ischemia; Cerebrovascular Circulation; Energy Metabolism; Extracellular Space; Fe | 2001 |