nitrites has been researched along with Brain Edema in 16 studies
Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Melatonin at 60 min post ischemia rendered neuroprotection as evident by reduction in cerebral infarct volume, improvement in motor and neurological deficit and reduction in brain edema." | 7.80 | Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia. ( Bhattacharya, P; Pandey, AK; Patnaik, R; Paul, S, 2014) |
| "Findings of the present study provide significant evidence that Piroxicam acts as a potent AQP4 regulator and renders neuroprotection in focal cerebral ischemia." | 7.79 | Aquaporin-4 inhibition mediates piroxicam-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rodents. ( Bhattacharya, P; Pandey, AK; Patnaik, R; Paul, S; Yavagal, DR, 2013) |
| "Melatonin at 60 min post ischemia rendered neuroprotection as evident by reduction in cerebral infarct volume, improvement in motor and neurological deficit and reduction in brain edema." | 3.80 | Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia. ( Bhattacharya, P; Pandey, AK; Patnaik, R; Paul, S, 2014) |
| "Findings of the present study provide significant evidence that Piroxicam acts as a potent AQP4 regulator and renders neuroprotection in focal cerebral ischemia." | 3.79 | Aquaporin-4 inhibition mediates piroxicam-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rodents. ( Bhattacharya, P; Pandey, AK; Patnaik, R; Paul, S; Yavagal, DR, 2013) |
| "We investigated whether treatment with the nitric oxide synthase inhibitor N-nitro-L-arginine (L-NA) and the free radical scavenger superoxide dismutase influences cerebral blood flow changes, brain edema, and cerebrospinal fluid pleocytosis in early experimental pneumococcal meningitis." | 3.69 | Experimental pneumococcal meningitis: cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide. ( Bernatowicz, A; Fontana, A; Frei, K; Koedel, U; Paul, R; Pfister, HW, 1995) |
| "Brain edema was determined by means of the wet-dry weight method and assessed with light microscopy on H&E-stained preparations of tissues obtained 6 and 24 hours after glyceryl trinitrate treatment." | 1.42 | Effects of nitric oxide on blood-brain barrier permeability in common carp (Cyprinus carpio L.). ( Gjurcevic, E; Ivkic, G; Klaric, MŠ; Kovacić, S; Rumora, L, 2015) |
| " Among the causative factors of BBB disruption are accelerating peroxynitrite formation and the resultant decreased bioavailability of nitric oxide (NO)." | 1.38 | The inhibitory effect of S-nitrosoglutathione on blood-brain barrier disruption and peroxynitrite formation in a rat model of experimental stroke. ( Dhammu, TS; Gilg, AG; Khan, M; Sakakima, H; Shunmugavel, A; Singh, AK; Singh, I, 2012) |
| "We concluded that curcumin ameliorates cerebral ischemia/reperfusion injury by preventing ONOO(-) mediated blood-brain barrier damage." | 1.34 | Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage. ( Hu, M; Jiang, J; Li, F; Sun, YJ; Wang, W; Zhu, DY, 2007) |
| "LPS induced cytotoxic brain swelling and maintained anatomical integrity of the blood-brain barrier." | 1.34 | Endotoxemia produces coma and brain swelling in bile duct ligated rats. ( Brooks, HF; Davies, C; Davies, NA; Harry, D; Hodges, SJ; Jalan, R; Mani, AR; Moore, KP; Shawcross, DL; Stadlbauer, V; Williams, R; Wright, G; Zou, Z; Zwingmann, C, 2007) |
| "Melatonin treatment increased survival and reduced hyperactivity linked to neurodegeneration induced by cerebral ischemia and reperfusion." | 1.31 | Protective effects of melatonin in ischemic brain injury. ( Barberi, I; Caputi, AP; Cordaro, S; Costantino, G; Cuzzocrea, S; De Sarro, A; Fulia, F; Gitto, E; Mazzon, E; Serraino, I, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 9 (56.25) | 29.6817 |
| 2010's | 5 (31.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhattacharya, P | 2 |
| Pandey, AK | 2 |
| Paul, S | 2 |
| Patnaik, R | 2 |
| Yavagal, DR | 1 |
| Kovacić, S | 1 |
| Rumora, L | 1 |
| Gjurcevic, E | 1 |
| Klaric, MŠ | 1 |
| Ivkic, G | 1 |
| Dohare, P | 1 |
| Garg, P | 1 |
| Jain, V | 1 |
| Nath, C | 1 |
| Ray, M | 1 |
| Nagakannan, P | 1 |
| Shivasharan, BD | 1 |
| Thippeswamy, BS | 1 |
| Veerapur, VP | 1 |
| Bansal, P | 1 |
| Khan, M | 1 |
| Dhammu, TS | 1 |
| Sakakima, H | 1 |
| Shunmugavel, A | 1 |
| Gilg, AG | 1 |
| Singh, AK | 1 |
| Singh, I | 1 |
| Temiz, C | 1 |
| Tun, K | 1 |
| Ugur, HC | 1 |
| Dempsey, RJ | 1 |
| Egemen, N | 1 |
| Yatsushige, H | 1 |
| Calvert, JW | 1 |
| Cahill, J | 1 |
| Zhang, JH | 1 |
| Jiang, J | 1 |
| Wang, W | 1 |
| Sun, YJ | 1 |
| Hu, M | 1 |
| Li, F | 1 |
| Zhu, DY | 1 |
| Wright, G | 1 |
| Davies, NA | 1 |
| Shawcross, DL | 1 |
| Hodges, SJ | 1 |
| Zwingmann, C | 1 |
| Brooks, HF | 1 |
| Mani, AR | 1 |
| Harry, D | 1 |
| Stadlbauer, V | 1 |
| Zou, Z | 2 |
| Williams, R | 1 |
| Davies, C | 1 |
| Moore, KP | 1 |
| Jalan, R | 1 |
| Koedel, U | 1 |
| Bernatowicz, A | 1 |
| Paul, R | 1 |
| Frei, K | 1 |
| Fontana, A | 1 |
| Pfister, HW | 1 |
| Master, S | 1 |
| Gottstein, J | 1 |
| Blei, AT | 1 |
| Calapai, G | 2 |
| Marciano, MC | 2 |
| Corica, F | 1 |
| Allegra, A | 1 |
| Parisi, A | 2 |
| Frisina, N | 1 |
| Caputi, AP | 4 |
| Buemi, M | 1 |
| Cuzzocrea, S | 2 |
| McDonald, MC | 1 |
| Mazzon, E | 2 |
| Siriwardena, D | 1 |
| Costantino, G | 2 |
| Fulia, F | 2 |
| Cucinotta, G | 1 |
| Gitto, E | 2 |
| Cordaro, S | 2 |
| Barberi, I | 2 |
| De Sarro, A | 2 |
| Thiemermann, C | 1 |
| Serraino, I | 1 |
| Crupi, A | 1 |
| Firenzuoli, F | 1 |
| Squadrito, F | 1 |
| Inferrera, G | 1 |
| Rizzo, A | 1 |
| Crisafulli, C | 1 |
| Fiore, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Shuxuening Injection for the Prevention of Cerebral Vasospasm in Patients With Aneurysmal Subarachnoid Hemorrhage -- A Randomized, Double-blind, Placebo-parallel Controlled Clinical Trial[NCT06138353] | Phase 2/Phase 3 | 50 participants (Anticipated) | Interventional | 2023-11-13 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 other studies available for nitrites and Brain Edema
| Article | Year |
|---|---|
Aquaporin-4 inhibition mediates piroxicam-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rodents.
Topics: Animals; Aquaporin 4; Brain; Brain Edema; Brain Infarction; Brain Ischemia; Calcium; Dose-Response R | 2013 |
Melatonin renders neuroprotection by protein kinase C mediated aquaporin-4 inhibition in animal model of focal cerebral ischemia.
Topics: Animals; Antioxidants; Apoptosis; Aquaporin 4; Blotting, Western; Brain Edema; Brain Ischemia; Calci | 2014 |
Effects of nitric oxide on blood-brain barrier permeability in common carp (Cyprinus carpio L.).
Topics: Animals; Blood-Brain Barrier; Brain Edema; Carps; Nitrates; Nitric Oxide; Nitrites; Nitroglycerin; P | 2015 |
Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat.
Topics: Animals; Behavior, Animal; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Curcumin; Disea | 2008 |
Protective effect of hydroalcoholic extract of Mimusops elengi Linn. flowers against middle cerebral artery occlusion induced brain injury in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Behavior, Animal; Blood-Brain Barrier; Brain Edema; | 2012 |
The inhibitory effect of S-nitrosoglutathione on blood-brain barrier disruption and peroxynitrite formation in a rat model of experimental stroke.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Edema; Carrier Proteins; Disease Models, Animal; E-Select | 2012 |
L-arginine in focal cerebral ischemia.
Topics: Animals; Arginine; Brain Edema; Brain Ischemia; Neuroprotective Agents; Nitrates; Nitric Oxide; Nitr | 2003 |
Limited role of inducible nitric oxide synthase in blood-brain barrier function after experimental subarachnoid hemorrhage.
Topics: Animals; Benzenesulfonates; Blood-Brain Barrier; Brain Edema; Disease Models, Animal; Male; Nitrates | 2006 |
Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage.
Topics: Animals; Astrocytes; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Capillaries; Curcuma; Curcumi | 2007 |
Endotoxemia produces coma and brain swelling in bile duct ligated rats.
Topics: Ammonia; Animals; Brain; Brain Edema; Capillaries; Cholestasis, Extrahepatic; Coma; Consciousness; C | 2007 |
Experimental pneumococcal meningitis: cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Arterioles; Brain Edema; Cells, Cultured; Cerebral Ar | 1995 |
Cerebral blood flow and the development of ammonia-induced brain edema in rats after portacaval anastomosis.
Topics: Ammonia; Animals; Brain; Brain Edema; Cerebrovascular Circulation; Cranial Sinuses; Hemodynamics; In | 1999 |
Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation.
Topics: Aldehydes; Animals; Brain; Brain Edema; Brain Ischemia; Erythropoietin; Gerbillinae; Humans; Injecti | 2000 |
Effects of tempol, a membrane-permeable radical scavenger, in a gerbil model of brain injury.
Topics: Animals; Arterial Occlusive Diseases; Brain; Brain Edema; Cerebral Arteries; Cyclic N-Oxides; Free R | 2000 |
Protective effects of melatonin in ischemic brain injury.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Enzyme-Linked Immunosorbent Assay; Free Radical Scaveng | 2000 |
Neuroprotective effects of Ginkgo biloba extract in brain ischemia are mediated by inhibition of nitric oxide synthesis.
Topics: Administration, Oral; Animals; Brain; Brain Edema; Cell Death; Dose-Response Relationship, Drug; Ger | 2000 |