nitrites and Blood Poisoning studies

Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)

Research Excerpts

Excerpt	Relevance	Reference
"In mice with CLP-induced sepsis luteolin pre-treatment markedly increased the survival time and attenuated serum lactate level."	8.12	Luteolin alleviates vascular dysfunctions in CLP-induced polymicrobial sepsis in mice. ( Kumar, D; Lingaraju, MC; Mahobiya, A; Parida, S; Perumalraja, K; Rungsung, S; Sahoo, M; Sharma, M; Singh, TU, 2022)
" Curcumin (diferuloylmethane), a major component of turmeric, exhibits protection against LPS-induced acute lung injury (ALI)."	7.81	Intranasal curcumin ameliorates lipopolysaccharide-induced acute lung injury in mice. ( Dash, D; Kumari, A; Singh, R; Tyagi, N, 2015)
"The aim of the present study was to assess the effect of seven days daidzein pretreatment in cecal ligation and puncture (CLP) model of sepsis."	7.81	Daidzein pretreatment improves survival in mouse model of sepsis. ( Kandasamy, K; Mishra, SK; Narasimha Reddy, ChE; Panigrahi, M; Parida, S; Singh, TU; Singh, V; Thangamalai, R, 2015)
" The present study examined the effects of atorvastatin pretreatment on sepsis-induced endothelial dysfunctions and hypotension in rats."	7.75	Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis. ( Kathirvel, K; Kuntamallappanavar, G; Leo, MD; Mishra, SK; Subramani, J; Uttam Singh, T, 2009)
"It is demonstrated that administration of arginine together with the selective iNOS inhibitor in the early phase of sepsis restores plasma arginine, reduces oxidative stress by probably maintaining NO derived from constitutive NOS, and attenuates neuroendocrine stress responses."	7.74	The effects of arginine and selective inducible nitric oxide synthase inhibitor on pathophysiology of sepsis in a CLP model. ( Akaishi, S; Endo, T; Hojo, N; Kobayashi, M; Kudo, D; Nomura, R; Sasaki, J; Shinozawa, Y; Takuma, K; Xie, XQ; Yamanouchi, S, 2008)
"To investigate the effects of glutamine (GLN)-enriched diets before and GLN-containing total parenteral nutrition (TPN) after sepsis or both on the secretion of cytokines and their mRNA expression levels in splenocytes of rats with septic peritonitis."	7.73	Effects of glutamine supplementation on splenocyte cytokine mRNA expression in rats with septic peritonitis. ( Chen, WJ; Chiu, WC; Lai, YN; Lin, MT; Shang, HF; Yeh, SL, 2005)
"To determine the changes in plasma nitrite/nitrate (NOx) and endothelin-1 (ET-1) concentrations during neonatal sepsis."	7.72	Plasma nitrite/nitrate and endothelin-1 concentrations in neonatal sepsis. ( Carbonell-Estrany, X; Figueras-Aloy, J; Gómez, L; Jiménez, W; Jordán, Y; Rodríguez-Miguélez, JM; Salvia, MD, 2003)
"Monophosphoryl lipid A (MLA), a substructure of bacterial lipopolysaccharide (LPS), is being developed as a prophylactic for sepsis and septic shock."	7.68	A rationale for the prophylactic use of monophosphoryl lipid A in sepsis and septic shock. ( Gustafson, GL; Rhodes, MJ, 1992)
"Sepsis is caused by a dysregulated host response to infection, often associated with acute central nervous system (CNS) dysfunction, which results in long-term cognitive impairment."	5.48	Dimethyl Fumarate Limits Neuroinflammation and Oxidative Stress and Improves Cognitive Impairment After Polymicrobial Sepsis. ( Barichello, T; da Rosa, N; Danielski, LG; de Oliveira Junior, AN; de Souza Goldim, MP; Florentino, D; Fortunato, JJ; Giustina, AD; Gomes, ML; Laurentino, AO; Mathias, K; Moreira, AP; Petronilho, F; Schuck, PF; Steckert, AV; Trombetta, T; Zarbato, GF, 2018)
"Septic acute lung injury is characterized by severe oxidative stress response, remained refractory to present therapies, and new therapies need to be developed to improve further clinical outcomes."	5.42	Betulinic acid negates oxidative lung injury in surgical sepsis model. ( Balaganur, V; Begum, J; Bhat, RA; Kumar, D; Lingaraju, MC; Pathak, NN; Ram, M; Tandan, SK, 2015)
"Genipin was found to improve survival and to attenuate multiple organ dysfunction."	5.38	Genipin attenuates sepsis by inhibiting Toll-like receptor signaling. ( Kim, TH; Lee, SM; Yoon, SJ, 2012)
"Inflammation is difficult to control when it spreads throughout the body and often progresses into multiple organ dysfunction, eventually leading to death."	5.37	Cepharanthine exerts anti-inflammatory effects via NF-κB inhibition in a LPS-induced rat model of systemic inflammation. ( Hagiwara, S; Hasegawa, A; Koga, H; Kudo, K; Kusaka, J; Noguchi, T, 2011)
"Sepsis was produced by the CLP procedure."	5.33	N-acetylcysteine protects the rats against phrenic nerve dysfunction in sepsis. ( Atis, S; Bagdatoglu, O; Comelekoglu, U; Gunes, S; Nayci, A; Ozge, A, 2006)
"Development of severe sepsis is thought to result from the overproduction of cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and nitric oxide."	5.31	Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis. ( Ando, H; Kobayashi, K; Nagai, Y; Ota, T; Takamura, T, 2000)
" To evaluate the effects of NO radical on the liver in patients with postoperative sepsis, we analysed both the stable end-product of nitric oxide radical (NOx) as well as the arterial KBR (AKBR), which reflects liver tissue NAD+/NADH."	5.09	Nitric oxide production and hepatic dysfunction in patients with postoperative sepsis. ( Inoue, T; Kamiyama, Y; Kitade, H; Kwon, AH; Satoi, S; Takahashi, H; Takahashi, K; Wei, T, 2000)
"In mice with CLP-induced sepsis luteolin pre-treatment markedly increased the survival time and attenuated serum lactate level."	4.12	Luteolin alleviates vascular dysfunctions in CLP-induced polymicrobial sepsis in mice. ( Kumar, D; Lingaraju, MC; Mahobiya, A; Parida, S; Perumalraja, K; Rungsung, S; Sahoo, M; Sharma, M; Singh, TU, 2022)
" Curcumin (diferuloylmethane), a major component of turmeric, exhibits protection against LPS-induced acute lung injury (ALI)."	3.81	Intranasal curcumin ameliorates lipopolysaccharide-induced acute lung injury in mice. ( Dash, D; Kumari, A; Singh, R; Tyagi, N, 2015)
"The aim of the present study was to assess the effect of seven days daidzein pretreatment in cecal ligation and puncture (CLP) model of sepsis."	3.81	Daidzein pretreatment improves survival in mouse model of sepsis. ( Kandasamy, K; Mishra, SK; Narasimha Reddy, ChE; Panigrahi, M; Parida, S; Singh, TU; Singh, V; Thangamalai, R, 2015)
" The present study examined the effects of atorvastatin pretreatment on sepsis-induced endothelial dysfunctions and hypotension in rats."	3.75	Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis. ( Kathirvel, K; Kuntamallappanavar, G; Leo, MD; Mishra, SK; Subramani, J; Uttam Singh, T, 2009)
"It is demonstrated that administration of arginine together with the selective iNOS inhibitor in the early phase of sepsis restores plasma arginine, reduces oxidative stress by probably maintaining NO derived from constitutive NOS, and attenuates neuroendocrine stress responses."	3.74	The effects of arginine and selective inducible nitric oxide synthase inhibitor on pathophysiology of sepsis in a CLP model. ( Akaishi, S; Endo, T; Hojo, N; Kobayashi, M; Kudo, D; Nomura, R; Sasaki, J; Shinozawa, Y; Takuma, K; Xie, XQ; Yamanouchi, S, 2008)
"To investigate the effects of glutamine (GLN)-enriched diets before and GLN-containing total parenteral nutrition (TPN) after sepsis or both on the secretion of cytokines and their mRNA expression levels in splenocytes of rats with septic peritonitis."	3.73	Effects of glutamine supplementation on splenocyte cytokine mRNA expression in rats with septic peritonitis. ( Chen, WJ; Chiu, WC; Lai, YN; Lin, MT; Shang, HF; Yeh, SL, 2005)
"Sepsis provokes an induction of inducible nitric oxide synthase (iNOS) and melatonin down-regulates its expression and activity."	3.73	Identification of an inducible nitric oxide synthase in diaphragm mitochondria from septic mice: its relation with mitochondrial dysfunction and prevention by melatonin. ( Acuña-Castroviejo, D; Escames, G; León, J; López, LC; Tapias, V; Utrilla, P, 2006)
"Peritonitis sepsis induced multiple organ dysfunction, mitochondrial abnormalities, and increased mortality rate, which were reduced by pharmacological inhibition of mitochondrial transition by cyclosporine derivatives and mitochondrial Bcl-2 overexpression."	3.73	Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality. ( Chopin, C; Decoster, B; Favory, R; Hassoun, SM; Lancel, S; Larche, J; Marchetti, P; Neviere, R, 2006)
"To determine the changes in plasma nitrite/nitrate (NOx) and endothelin-1 (ET-1) concentrations during neonatal sepsis."	3.72	Plasma nitrite/nitrate and endothelin-1 concentrations in neonatal sepsis. ( Carbonell-Estrany, X; Figueras-Aloy, J; Gómez, L; Jiménez, W; Jordán, Y; Rodríguez-Miguélez, JM; Salvia, MD, 2003)
"Children with sepsis had a twofold reduction in antipyrine clearance."	3.72	Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure. ( Burckart, GJ; Carcillo, JA; Doughty, L; Frye, RF; Kaplan, SS; Kofos, D; Sasser, H, 2003)
"Bicuculline methiodide attenuates inflammation by inhibiting the production of proinflammatory cytokines, such as tumor necrosis factor-alpha, and by increasing the production of the anti-inflammatory cytokine interleukin-10, both of which play important roles in the pathogenesis of sepsis."	3.72	Bicuculline methiodide attenuates hepatic injury and decreases mortality in septic rats: role of cytokines. ( Hsu, DZ; Liu, MY, 2004)
"To analyze the mechanism of vasodilation and circulatory shock occurring in patients who are treated with isolated limb perfusion with melphalan and recombinant tumor necrosis factor (TNF)-alpha for locally advanced malignant tumors."	3.69	Role of nitric oxide in recombinant tumor necrosis factor-alpha-induced circulatory shock: a study in patients treated for cancer with isolated limb perfusion. ( Donse, IF; Girbes, AR; Hoekstra, HJ; Maring, JK; Moshage, H; Schraffordt Koops, H; van Ginkel, RJ; Zwaveling, JH, 1996)
"Increased plasma nitrite/nitrates and increased organ failure scores occurred in the children with sepsis who had an exaggerated proinflammatory state, despite a pronounced anti-inflammatory response."	3.69	Inflammatory cytokine and nitric oxide responses in pediatric sepsis and organ failure. ( Carcillo, JA; Doughty, LA; Kaplan, SS, 1996)
"Monophosphoryl lipid A (MLA), a substructure of bacterial lipopolysaccharide (LPS), is being developed as a prophylactic for sepsis and septic shock."	3.68	A rationale for the prophylactic use of monophosphoryl lipid A in sepsis and septic shock. ( Gustafson, GL; Rhodes, MJ, 1992)
"Treatment with gentamicin stabilized cardiac index (BL, 5."	2.71	Gentamicin improves hemodynamics in ovine septic shock after smoke inhalation injury. ( Enkhbaatar, P; Heggers, JP; Herndon, DN; Jodoin, JM; Maybauer, DM; Maybauer, MO; Morita, N; Traber, DL; Traber, LD; Westphal, M, 2005)
"Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection."	1.72	Lung-Brain Crosstalk in Sepsis: Protective Effect of Prophylactic Physical Exercise Against Inflammation and Oxidative Stress in Rats. ( Bagio, E; Bonfante, S; Cardoso, T; Dacoregio, C; Danielski, LG; de Souza Goldim, MP; Giustina, AD; Joaquim, L; Machado, RS; Mathias, K; Petronilho, F; Pinho, RA; Predroso, GS; Rodrigues, JF; Silveira, PCL; Stork, S; Venturini, LM; Zaccaron, RP; Zarbato, G, 2022)
"Sepsis is caused by a dysregulated host response to infection, often associated with acute central nervous system (CNS) dysfunction, which results in long-term cognitive impairment."	1.48	Dimethyl Fumarate Limits Neuroinflammation and Oxidative Stress and Improves Cognitive Impairment After Polymicrobial Sepsis. ( Barichello, T; da Rosa, N; Danielski, LG; de Oliveira Junior, AN; de Souza Goldim, MP; Florentino, D; Fortunato, JJ; Giustina, AD; Gomes, ML; Laurentino, AO; Mathias, K; Moreira, AP; Petronilho, F; Schuck, PF; Steckert, AV; Trombetta, T; Zarbato, GF, 2018)
"Sepsis was induced in male Wistar rats by cecal ligation and puncture (CLP)."	1.46	Nitrite administration improves sepsis-induced myocardial and mitochondrial dysfunction by modulating stress signal responses. ( Hayashi, S; Hirata, N; Inoue, S; Kawaguchi, R; Tokinaga, Y; Watanabe, N; Yamakage, M, 2017)
"Septic acute lung injury is characterized by severe oxidative stress response, remained refractory to present therapies, and new therapies need to be developed to improve further clinical outcomes."	1.42	Betulinic acid negates oxidative lung injury in surgical sepsis model. ( Balaganur, V; Begum, J; Bhat, RA; Kumar, D; Lingaraju, MC; Pathak, NN; Ram, M; Tandan, SK, 2015)
"Acute kidney injury is a frequent and serious complication of sepsis."	1.38	Development of oxidative stress in the peritubular capillary microenvironment mediates sepsis-induced renal microcirculatory failure and acute kidney injury. ( Gokden, N; Holthoff, JH; Mayeux, PR; Pathak, E; Seely, KA; Spencer, HJ; Wang, Z, 2012)
"Genipin was found to improve survival and to attenuate multiple organ dysfunction."	1.38	Genipin attenuates sepsis by inhibiting Toll-like receptor signaling. ( Kim, TH; Lee, SM; Yoon, SJ, 2012)
"Inflammation is difficult to control when it spreads throughout the body and often progresses into multiple organ dysfunction, eventually leading to death."	1.37	Cepharanthine exerts anti-inflammatory effects via NF-κB inhibition in a LPS-induced rat model of systemic inflammation. ( Hagiwara, S; Hasegawa, A; Koga, H; Kudo, K; Kusaka, J; Noguchi, T, 2011)
"Results Patients who developed septic shock (n = 35) had higher plasma NOx, total and free cortisol, and lower CBG concentrations than the nonseptic shock group (n = 27)."	1.36	Characteristics of plasma NOx levels in severe sepsis: high interindividual variability and correlation with illness severity, but lack of correlation with cortisol levels. ( Chapman, MJ; Edwards, J; Ho, JT; Lam, S; Lewis, JG; Ludbrook, G; O'Connor, S; Torpy, DJ, 2010)
"Sepsis is the leading cause of death in critically ill patients."	1.35	Inhibitory effect of a phosphatidyl ethanolamine derivative on LPS-induced sepsis. ( An, HJ; Kim, JL; Lee, C; Lee, H; Paik, SG, 2009)
"Smoke inhalation injury is often complicated with pneumonia, which frequently leads to subsequent development of sepsis."	1.35	Role of neuronal nitric oxide synthase in ovine sepsis model. ( Enkhbaatar, P; Hamahata, A; Herndon, D; Jaroch, S; Jonkam, C; Lange, M; Nakano, Y; Traber, D; Traber, L; Wang, J, 2009)
"Severe sepsis is the leading cause of death for patients in intensive care units."	1.34	Heat shock protein 90 inhibitors prolong survival, attenuate inflammation, and reduce lung injury in murine sepsis. ( Antonova, G; Cannon, J; Catravas, JD; Chatterjee, A; Dimitropoulou, C; Drakopanayiotakis, F; Snead, C; Venema, RC, 2007)
"Sepsis was produced by the CLP procedure."	1.33	N-acetylcysteine protects the rats against phrenic nerve dysfunction in sepsis. ( Atis, S; Bagdatoglu, O; Comelekoglu, U; Gunes, S; Nayci, A; Ozge, A, 2006)
"Sepsis was induced by intraperitoneal (i."	1.33	Role of oxidative stress in the pathogenesis of septic ileus in mice. ( Bredenoord, AJ; de Jonge, F; de Man, JG; de Winter, BY; Herman, AG; Pelckmans, PA; Seerden, TC; Timmermans, JP; van Nassauw, L, 2005)
"Sepsis is one of the common causes of acute renal failure (ARF)."	1.33	Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure. ( Dear, JW; Gladwin, MT; Hewitt, SM; Holly, MK; Hu, X; Schechter, AN; Star, RA; Yuen, PS, 2006)
"Sepsis is an acute inflammatory disease characterized by dysfunctional blood flow and hypotension."	1.32	Transduction of NO-bioactivity by the red blood cell in sepsis: novel mechanisms of vasodilation during acute inflammatory disease. ( Chacko, BK; Crawford, JH; Hogg, N; Patel, RP; Piknova, B; Pruitt, HM, 2004)
"The mechanism of gut injury in endotoxic shock seems unrelated to hypoxia and release of nitric oxide."	1.32	Gut mucosal damage during endotoxic shock is due to mechanisms other than gut ischemia. ( De Backer, D; Dimopoulos, G; Lobo, SM; Nagy, N; Preiser, JC; Sun, Q; Terzi, RG; Tu, Z; Vercruy, V; Vincent, JL; Vray, B, 2003)
"Recent findings in human septic shock suggest that glucocorticosteroids can limit and even reverse hemodynamic disturbances and dependence on catecholamines."	1.32	Hemodynamic effects of early versus late glucocorticosteroid administration in experimental septic shock. ( Bollaert, PE; Levy, B; Longrois, D; Mallié, JP; Mansart, A; Seguin, C, 2003)
"Polymicrobial sepsis is characterized by an early, hyperdynamic phase (i."	1.31	Upregulation of inducible nitric oxide synthase and nitric oxide occurs later than the onset of the hyperdynamic response during sepsis. ( Chaudry, IH; Ornan, DA; Shieh, P; Wang, P; Zhou, M, 2000)
"Development of severe sepsis is thought to result from the overproduction of cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta), and nitric oxide."	1.31	Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis. ( Ando, H; Kobayashi, K; Nagai, Y; Ota, T; Takamura, T, 2000)
"Bone resorption was assessed by measurement of urinary pyridinoline and deoxypyridinoline as a ratio to urinary creatinine."	1.31	Increased bone resorption in the critically ill: association with sepsis and increased nitric oxide production. ( Cuthbertson, B; Harvie, J; Ralston, SH; Robins, S; Smith, LM; Webster, N, 2002)
"This study documents that trauma induces alterations in the inflammatory cytokine cascade that affect the immune response to subsequent septic challenges."	1.29	Polymicrobial sepsis following trauma inhibits interleukin-10 secretion and lymphocyte proliferation. ( Campbell, C; Napolitano, LM, 1995)

Research

Studies (106)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

All-cause 28-day Mortality Rate.

Antibiotic-free Days

Incidence of Prolonged Lymphopenia (Absolute Lymphocyte Count Less Than or Equal to 1,000/mm³ for > or Equal to 7 Days)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (2.83)	18.7374
1990's	17 (16.04)	18.2507
2000's	54 (50.94)	29.6817
2010's	28 (26.42)	24.3611
2020's	4 (3.77)	2.80

Authors	Studies
Giustina, AD	3
Rodrigues, JF	1
Bagio, E	1
Bonfante, S	2
Joaquim, L	2
Zarbato, G	1
Stork, S	1
Machado, RS	1
de Souza Goldim, MP	3
Danielski, LG	4
Mathias, K	2
Dacoregio, C	1
Cardoso, T	1
Predroso, GS	1
Venturini, LM	1
Zaccaron, RP	1
Silveira, PCL	1
Pinho, RA	1
Petronilho, F	5
Xie, Q	1
Wang, Y	1
Zou, GL	1
Rungsung, S	1
Singh, TU	2
Perumalraja, K	1
Mahobiya, A	1
Sharma, M	1
Lingaraju, MC	2
Parida, S	2
Sahoo, M	1
Kumar, D	3
Metzker, KL	1
Biehl, EB	1
Vieira, T	1
de Medeiros, FD	1
da Rosa, N	2
Generoso, J	1
Simoes, L	1
Farias, HR	1
da Silva Lemos, I	1
Giridharan, V	1
Rezin, GT	1
Fortunato, JJ	3
Bitencourt, RM	1
Streck, EL	1
Dal-Pizzol, F	3
Barichello, T	3
Santos-Junior, NN	1
Costa, LHA	1
Catalão, CHR	1
Kanashiro, A	1
Sharshar, T	1
Rocha, MJA	1
Kawaguchi, R	1
Hirata, N	1
Tokinaga, Y	1
Hayashi, S	1
Inoue, S	1
Watanabe, N	1
Yamakage, M	1
Zarbato, GF	1
Florentino, D	2
de Oliveira Junior, AN	1
Laurentino, AO	1
Trombetta, T	1
Gomes, ML	1
Steckert, AV	1
Moreira, AP	1
Schuck, PF	1
Sordi, R	1
Menezes-de-Lima, O	1
Della-Justina, AM	1
Rezende, E	1
Assreuy, J	1
Vieira, A	1
Michels, M	1
Lauriano, AA	1
Quevedo, J	1
Pathak, NN	1
Begum, J	1
Balaganur, V	1
Bhat, RA	1
Ram, M	1
Tandan, SK	1
Shen, HH	1
Lam, KK	1
Cheng, PY	1
Kung, CW	1
Chen, SY	1
Lin, PC	1
Chung, MT	1
Lee, YM	2
Kumari, A	1
Tyagi, N	1
Dash, D	1
Singh, R	1
Thangamalai, R	1
Narasimha Reddy, ChE	1
Panigrahi, M	1
Kandasamy, K	1
Singh, V	1
Mishra, SK	2
Lauer, S	1
Fischer, LG	1
Van Aken, HK	1
Nofer, JR	1
Freise, H	1
Alvarez de Sotomayor, M	1
Vega, S	1
Mingorance, C	1
Marhuenda, E	1
Herrera, MD	1
Guo, LY	1
Hung, TM	1
Bae, KH	1
Shin, EM	1
Zhou, HY	1
Hong, YN	1
Kang, SS	1
Kim, HP	1
Kim, YS	1
Enkhbaatar, P	4
Lange, M	2
Nakano, Y	2
Hamahata, A	2
Jonkam, C	2
Wang, J	1
Jaroch, S	1
Traber, L	1
Herndon, D	1
Traber, D	1
Lee, C	1
An, HJ	1
Kim, JL	1
Lee, H	1
Paik, SG	1
Subramani, J	1
Kathirvel, K	1
Leo, MD	1
Kuntamallappanavar, G	1
Uttam Singh, T	1
Morgan, MA	1
Frasier, LM	1
Stewart, JC	1
Mack, CM	1
Gough, MS	1
Graves, BT	1
Apostolakos, MJ	1
Doolin, KP	1
Darling, DC	1
Frampton, MW	1
Pietropaoli, AP	1
Kudo, K	1
Hagiwara, S	1
Hasegawa, A	1
Kusaka, J	1
Koga, H	1
Noguchi, T	1
Dezfulian, C	1
Trzeciak, S	1
Ho, JT	1
Chapman, MJ	1
O'Connor, S	1
Lam, S	1
Edwards, J	1
Ludbrook, G	1
Lewis, JG	1
Torpy, DJ	1
Guerreiro, MO	1
Andrades, M	1
Constantino, L	1
Mina, FG	1
Moreira, JC	1
Ritter, C	1
Connelly, R	1
Traber, DL	5
Esechie, A	1
von Borzyskowski, S	1
Traber, LD	5
Schmalstieg, FC	2
Herndon, DN	4
Barbeiro, DF	1
Barbeiro, HV	1
Faintuch, J	1
Ariga, SK	1
Mariano, M	1
Popi, AF	1
de Souza, HP	1
Velasco, IT	1
Soriano, FG	2
Lorigados, CB	1
Pacher, P	1
Szabó, C	1
Choumar, A	1
Tarhuni, A	1
Lettéron, P	1
Reyl-Desmars, F	1
Dauhoo, N	1
Damasse, J	1
Vadrot, N	1
Nahon, P	1
Moreau, R	1
Pessayre, D	1
Mansouri, A	1
Osterbur, K	1
Whitehead, Z	1
Sharp, CR	1
DeClue, AE	1
Waisman, D	1
Brod, V	1
Rahat, MA	1
Amit-Cohen, BC	1
Lahat, N	1
Rimar, D	1
Menn-Josephy, H	1
David, M	1
Lavon, O	1
Cavari, Y	1
Bitterman, H	1
Pathak, E	2
MacMillan-Crow, LA	1
Mayeux, PR	2
Li, H	1
Qian, Z	1
Li, J	1
Han, X	1
Liu, M	1
Wang, Z	1
Holthoff, JH	1
Seely, KA	1
Spencer, HJ	1
Gokden, N	1
De Filippis, D	1
Esposito, G	1
Cirillo, C	1
Cipriano, M	1
De Winter, BY	2
Scuderi, C	1
Sarnelli, G	1
Cuomo, R	1
Steardo, L	1
De Man, JG	2
Iuvone, T	1
Kim, TH	1
Yoon, SJ	1
Lee, SM	1
Jung, JS	1
Shin, KO	1
Shin, JA	1
Park, EM	1
Jeong, J	1
Kim, DH	1
Choi, JW	1
Kim, HS	1
van de Sandt, AM	1
Windler, R	1
Gödecke, A	1
Ohlig, J	1
Zander, S	1
Reinartz, M	1
Graf, J	1
van Faassen, EE	1
Rassaf, T	1
Schrader, J	1
Kelm, M	1
Merx, MW	1
Khadour, FH	1
Panas, D	1
Ferdinandy, P	1
Schulze, C	1
Csont, T	1
Lalu, MM	1
Wildhirt, SM	1
Schulz, R	1
Lim, DS	1
Bae, KG	1
Jung, IS	1
Kim, CH	1
Yun, YS	1
Song, JY	1
Murakami, K	2
McGuire, R	2
Cox, RA	2
Jodoin, JM	2
Bjertnaes, LJ	1
Katahira, J	1
Hawkins, HK	2
Mansart, A	1
Bollaert, PE	1
Seguin, C	1
Levy, B	1
Longrois, D	1
Mallié, JP	1
Carcillo, JA	5
Doughty, L	3
Kofos, D	1
Frye, RF	1
Kaplan, SS	3
Sasser, H	2
Burckart, GJ	1
Soop, A	1
Sollevi, A	1
Weitzberg, E	1
Lundberg, JO	1
Palm, J	1
Albert, J	1
Tunçtan, B	2
Altug, S	2
Uludag, O	2
Demirkay, B	1
Abacioglu, N	2
Figueras-Aloy, J	1
Gómez, L	1
Rodríguez-Miguélez, JM	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
The Critical Illness Stress-induced Immune Suppression Prevention Trial[NCT00395161]	Phase 3	293 participants (Actual)	Interventional	2007-04-30	Terminated (stopped due to Terminated for futility on 11/30/09 based on the recommendation of the DSMB)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	participants (Number)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide	15
Enteral Whey Protein, IV Saline	8

Intervention	Days (Median)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide	1
Enteral Whey Protein, IV Saline	2

What is reported is the number of participants with counts qualifying as lymphopenia. (NCT00395161)
Timeframe: from time of PICU admission till discharge from PICU

Rate of Nosocomial Infection or Clinical Sepsis Per 100 Study Days

The Primary Endpoint of This Study is the Median Time Between Admission to the PICU and Occurrence of Nosocomial Infection or Clinical Sepsis in PICU Patients Who Have Endotracheal Tubes, Central Venous Catheters, or Urinary Catheters.

Intervention	participants (Number)
Enteral Zinc, Selenium, Glutamine, and IV Metoclopramide	5
Enteral Whey Protein, IV Saline	12

Intervention	Mean number of events per 100 study days (Mean)
Daily Nutriceutical Supplementation	4.99
Whey Protein	4.83

(NCT00395161)
Timeframe: 48 hours after admission until 5 days after discharged from the PICU

Article	Year
Nitric oxide production in neonatal and pediatric sepsis. Critical care medicine, 1999, Volume: 27, Issue:6 Topics: Adult; Animals; Child; Humans; Infant, Newborn; Meningococcal Infections; Nitrates; Nitric Oxide; Ni	1999
[Pediatrics in 1976]. La Revue du praticien, 1977, Jan-21, Volume: 27, Issue:5 Topics: Adolescent; alpha 1-Antitrypsin Deficiency; Body Weight; Carcinoma, Hepatocellular; Catheterization;	1977

Article	Year
Gentamicin improves hemodynamics in ovine septic shock after smoke inhalation injury. Shock (Augusta, Ga.), 2005, Volume: 24, Issue:3 Topics: Animals; Arteries; Blood Pressure; Female; Gentamicins; Hemodynamics; Lung; Nitrates; Nitric Oxide;	2005
Nitric oxide production and hepatic dysfunction in patients with postoperative sepsis. Clinical and experimental pharmacology & physiology, 2000, Volume: 27, Issue:3 Topics: Aged; Female; Humans; Ketone Bodies; Liver Diseases; Male; Mitochondria, Liver; Multiple Organ Failu	2000

Article	Year
Lung-Brain Crosstalk in Sepsis: Protective Effect of Prophylactic Physical Exercise Against Inflammation and Oxidative Stress in Rats. Molecular neurobiology, 2022, Volume: 59, Issue:6 Topics: Animals; Antioxidants; Brain; Disease Models, Animal; Inflammation; Interleukin-6; Lung; Male; Nitri	2022
Protective effects of lavender oil on sepsis-induced acute lung injury via regulation of the NF-κB pathway. Pharmaceutical biology, 2022, Volume: 60, Issue:1 Topics: Acute Lung Injury; Animals; Lavandula; Lung; NF-kappa B; NF-KappaB Inhibitor alpha; Nitrites; Oils,	2022
Luteolin alleviates vascular dysfunctions in CLP-induced polymicrobial sepsis in mice. Pharmacological reports : PR, 2022, Volume: 74, Issue:5 Topics: Acetylcholine; Animals; Humans; Lactates; Luteolin; Mice; Nitric Oxide; Nitric Oxide Synthase Type I	2022
NLRP3 Activation Contributes to Acute Brain Damage Leading to Memory Impairment in Sepsis-Surviving Rats. Molecular neurobiology, 2020, Volume: 57, Issue:12 Topics: Acute Disease; Animals; Astrocytes; Brain; Catalase; Cytokines; Electron Transport; Glial Fibrillary	2020
Impairment of osmotic challenge-induced neurohypophyseal hormones secretion in sepsis survivor rats. Pituitary, 2017, Volume: 20, Issue:5 Topics: Animals; Hypothalamus; Interleukin-1beta; Interleukin-6; Nitrites; Proto-Oncogene Proteins c-fos; Ra	2017
Nitrite administration improves sepsis-induced myocardial and mitochondrial dysfunction by modulating stress signal responses. Journal of anesthesia, 2017, Volume: 31, Issue:6 Topics: Animals; Disease Models, Animal; Heart; Male; Mitochondria; Myocardium; NF-kappa B; Nitrites; Rats;	2017
Dimethyl Fumarate Limits Neuroinflammation and Oxidative Stress and Improves Cognitive Impairment After Polymicrobial Sepsis. Neurotoxicity research, 2018, Volume: 34, Issue:3 Topics: Animals; Catalase; Cognition Disorders; Cytokines; Dimethyl Fumarate; Disease Models, Animal; Explor	2018
Pneumonia-induced sepsis in mice: temporal study of inflammatory and cardiovascular parameters. International journal of experimental pathology, 2013, Volume: 94, Issue:2 Topics: Animals; Bacterial Load; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Humans; Kl	2013
Increased on oxidative brain injury in the diabetic rats following sepsis. Synapse (New York, N.Y.), 2014, Volume: 68, Issue:9 Topics: Animals; Brain; Catalase; Diabetes Mellitus, Experimental; Male; Nitrates; Nitrites; Peroxidase; Pro	2014
Betulinic acid negates oxidative lung injury in surgical sepsis model. The Journal of surgical research, 2015, Volume: 193, Issue:2 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Betulinic Acid; Dinoprost; Drug Eval	2015
Alpha-lipoic acid prevents endotoxic shock and multiple organ dysfunction syndrome induced by endotoxemia in rats. Shock (Augusta, Ga.), 2015, Volume: 43, Issue:4 Topics: Animals; Antioxidants; Antithrombins; Aorta; Caspase 3; Disulfides; Endotoxemia; Enzyme Activation;	2015
Intranasal curcumin ameliorates lipopolysaccharide-induced acute lung injury in mice. Inflammation, 2015, Volume: 38, Issue:3 Topics: Acute Lung Injury; Administration, Intranasal; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bro	2015
Daidzein pretreatment improves survival in mouse model of sepsis. The Journal of surgical research, 2015, Volume: 197, Issue:2 Topics: Acute Lung Injury; Animals; Bacterial Load; Biomarkers; Cecum; Corticosterone; Drug Administration S	2015
Gadolinium chloride modulates bradykinin-induced pulmonary vasoconstriction and hypoxic pulmonary vasoconstriction during polymicrobial abdominal sepsis in rats. Experimental lung research, 2015, Volume: 41, Issue:5 Topics: Animals; Bradykinin; Endothelium; Gadolinium; Hypoxia; Lung; Macrophages, Alveolar; Male; Nitric Oxi	2015
Effects of HMG-CoA reductase inhibition by simvastatin on vascular dysfunction induced by lipopolysaccharide in rats. Pharmacology, 2008, Volume: 82, Issue:2 Topics: Animals; Aorta, Thoracic; Blood Pressure; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase	2008
Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill. European journal of pharmacology, 2008, Sep-04, Volume: 591, Issue:1-3 Topics: Animals; Anti-Inflammatory Agents; Capillary Permeability; Cell Line; Cyclooctanes; Cyclooxygenase 2	2008
Role of neuronal nitric oxide synthase in ovine sepsis model. Shock (Augusta, Ga.), 2009, Volume: 32, Issue:3 Topics: Animals; Disease Models, Animal; Female; Hemodynamics; Interleukin-6; Lung; Lung Injury; Nitrates; N	2009
Inhibitory effect of a phosphatidyl ethanolamine derivative on LPS-induced sepsis. Molecules and cells, 2009, Feb-28, Volume: 27, Issue:2 Topics: Adult; Animals; Cell Line; Enzyme-Linked Immunosorbent Assay; Humans; Kidney; Lipopolysaccharide Rec	2009
Atorvastatin restores the impaired vascular endothelium-dependent relaxations mediated by nitric oxide and endothelium-derived hyperpolarizing factors but not hypotension in sepsis. Journal of cardiovascular pharmacology, 2009, Volume: 54, Issue:6 Topics: Acetylcholine; Animals; Aorta; Atorvastatin; Biological Factors; Blood Cell Count; Blood Pressure; C	2009
Artery-to-vein differences in nitric oxide metabolites are diminished in sepsis. Critical care medicine, 2010, Volume: 38, Issue:4 Topics: Age Factors; Aged; Arteries; Case-Control Studies; Cohort Studies; Female; Hemoglobins; Hospital Mor	2010
Cepharanthine exerts anti-inflammatory effects via NF-κB inhibition in a LPS-induced rat model of systemic inflammation. The Journal of surgical research, 2011, Volume: 171, Issue:1 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzylisoquinolines; Cell Line; Disease Models, An	2011
Reduced arteriovenous nitrite gradients associated with sepsis. Critical care medicine, 2010, Volume: 38, Issue:4 Topics: Arteries; Hemoglobins; Humans; Nitric Oxide; Nitrites; Sepsis; Veins	2010
Characteristics of plasma NOx levels in severe sepsis: high interindividual variability and correlation with illness severity, but lack of correlation with cortisol levels. Clinical endocrinology, 2010, Volume: 73, Issue:3 Topics: Analysis of Variance; Dobutamine; Epinephrine; Female; Humans; Hydrocortisone; Intensive Care Units;	2010
Plasma superoxide dismutase activity and mortality in septic patients [corrected]. The Journal of trauma, 2010, Volume: 69, Issue:6 Topics: APACHE; Biomarkers; Catalase; Chi-Square Distribution; Female; Humans; Male; Middle Aged; Multiple O	2010
Time course of nitric oxide synthases, nitrosative stress, and poly(ADP ribosylation) in an ovine sepsis model. Critical care (London, England), 2010, Volume: 14, Issue:4 Topics: Acute Lung Injury; Animals; Disease Models, Animal; Interleukin-8; Lung; Nitrates; Nitric Oxide Synt	2010
B-1 cells temper endotoxemic inflammatory responses. Immunobiology, 2011, Volume: 216, Issue:3 Topics: Animals; Animals, Genetically Modified; B-Lymphocyte Subsets; Coculture Techniques; Endotoxemia; Gen	2011
Effects of a potent peroxynitrite decomposition catalyst in murine models of endotoxemia and sepsis. Shock (Augusta, Ga.), 2011, Volume: 35, Issue:6 Topics: Animals; Endotoxemia; Lipopolysaccharides; Malondialdehyde; Metalloporphyrins; Mice; Nitrates; Nitri	2011
Lipopolysaccharide-induced mitochondrial DNA depletion. Antioxidants & redox signaling, 2011, Dec-01, Volume: 15, Issue:11 Topics: Aconitate Hydratase; Adenosine Triphosphate; Alanine Transaminase; Animals; ATP Synthetase Complexes	2011
Plasma nitrate/nitrite concentrations in dogs with naturally developing sepsis and non-infectious forms of the systemic inflammatory response syndrome. The Veterinary record, 2011, Nov-19, Volume: 169, Issue:21 Topics: Animals; Dog Diseases; Dogs; Female; Male; Nitrates; Nitrites; Predictive Value of Tests; Prospectiv	2011
Dose-related effects of hyperoxia on the lung inflammatory response in septic rats. Shock (Augusta, Ga.), 2012, Volume: 37, Issue:1 Topics: Animals; CD11 Antigens; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Re	2012
Role of mitochondrial oxidants in an in vitro model of sepsis-induced renal injury. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:1 Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Cecum; Cell Survival; Cells, Cultured; Epithel	2012
Effects of early administration of a novel anticholinergic drug on acute respiratory distress syndrome induced by sepsis. Medical science monitor : international medical journal of experimental and clinical research, 2011, Volume: 17, Issue:11 Topics: Animals; Bronchoalveolar Lavage Fluid; Cholinergic Antagonists; Injections, Intraperitoneal; Interle	2011
Development of oxidative stress in the peritubular capillary microenvironment mediates sepsis-induced renal microcirculatory failure and acute kidney injury. The American journal of pathology, 2012, Volume: 180, Issue:2 Topics: Acute Kidney Injury; Animals; Blood Pressure; Capillaries; Capillary Permeability; Cell Hypoxia; Cel	2012
Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis. PloS one, 2011, Volume: 6, Issue:12 Topics: Animals; Biopsy; Cannabidiol; Colitis, Ulcerative; Colon; Humans; Immune System; Inflammation; Inter	2011
Genipin attenuates sepsis by inhibiting Toll-like receptor signaling. Molecular medicine (Cambridge, Mass.), 2012, May-09, Volume: 18 Topics: Adaptor Proteins, Vesicular Transport; Animals; Anti-Inflammatory Agents; Cell Line; Cell Survival;	2012
Anti-inflammatory mechanism of exogenous C2 ceramide in lipopolysaccharide-stimulated microglia. Biochimica et biophysica acta, 2013, Volume: 1831, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Blotting, Western; Brain; Cell Proliferation; Cells, C	2013
Endothelial NOS (NOS3) impairs myocardial function in developing sepsis. Basic research in cardiology, 2013, Volume: 108, Issue:2 Topics: Animals; Arterial Pressure; Cardiac Output; Cardiomyopathies; Coronary Circulation; Disease Models,	2013
Enhanced NO and superoxide generation in dysfunctional hearts from endotoxemic rats. American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:3 Topics: Animals; Endotoxemia; Heart Diseases; Hydrogen Peroxide; Lipopolysaccharides; Male; Myocardial Contr	2002
Anti-septicaemic effect of polysaccharide from Panax ginseng by macrophage activation. The Journal of infection, 2002, Volume: 45, Issue:1 Topics: Animals; Anti-Bacterial Agents; Cytokines; Dose-Response Relationship, Drug; Female; Macrophage Acti	2002
Heparin nebulization attenuates acute lung injury in sepsis following smoke inhalation in sheep. Shock (Augusta, Ga.), 2002, Volume: 18, Issue:3 Topics: Animals; Blood Coagulation; Hemodynamics; Heparin; Lung; Nebulizers and Vaporizers; Nitrates; Nitrit	2002
Hemodynamic effects of early versus late glucocorticosteroid administration in experimental septic shock. Shock (Augusta, Ga.), 2003, Volume: 19, Issue:1 Topics: Adrenergic alpha-Agonists; Animals; Catecholamines; Cyclic AMP; Dexamethasone; Dose-Response Relatio	2003
Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure. Intensive care medicine, 2003, Volume: 29, Issue:6 Topics: Adolescent; Age Factors; Analysis of Variance; Antipyrine; Case-Control Studies; Child; Child, Presc	2003
Exhaled NO and plasma cGMP increase after endotoxin infusion in healthy volunteers. The European respiratory journal, 2003, Volume: 21, Issue:4 Topics: Adult; Analysis of Variance; Cyclic GMP; Endotoxins; Humans; Lipopolysaccharides; Luminescent Measur	2003
Effects of cyclooxygenase inhibitors on nitric oxide production and survival in a mice model of sepsis. Pharmacological research, 2003, Volume: 48, Issue:1 Topics: 6-Ketoprostaglandin F1 alpha; Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Diclofenac;	2003
Plasma nitrite/nitrate and endothelin-1 concentrations in neonatal sepsis. Acta paediatrica (Oslo, Norway : 1992), 2003, Volume: 92, Issue:5 Topics: Birth Weight; Endothelin-1; Female; Gestational Age; Humans; Infant, Newborn; Male; Nitrates; Nitrit	2003
Gut mucosal damage during endotoxic shock is due to mechanisms other than gut ischemia. Journal of applied physiology (Bethesda, Md. : 1985), 2003, Volume: 95, Issue:5 Topics: Animals; Blood Pressure; Carbon Dioxide; Ileum; Intestinal Mucosa; Ischemia; Lactic Acid; Lipopolysa	2003
[Nitrite blood poisoning]. Munchener medizinische Wochenschrift (1950), 1958, May-23, Volume: 100, Issue:21 Topics: Bacteremia; Cyanosis; Humans; Nitrites; Sepsis; Toxemia	1958
Isolevuglandins, a novel class of isoprostenoid derivatives, function as integrated sensors of oxidant stress and are generated by myeloperoxidase in vivo. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:15 Topics: Animals; Arachidonic Acid; Biomarkers; Candidiasis; Isoprostanes; Lipoproteins; Lipoproteins, LDL; M	2003
Effects of polyenylphosphatidylcholine on cytokines, nitrite/nitrate levels, antioxidant activity and lipid peroxidation in rats with sepsis. Intensive care medicine, 2004, Volume: 30, Issue:10 Topics: Animals; Antioxidants; Cytokines; Fat Emulsions, Intravenous; Female; Lipid Peroxidation; Models, An	2004
Effects of sesame oil on oxidative stress and hepatic injury after cecal ligation and puncture in rats. Shock (Augusta, Ga.), 2004, Volume: 21, Issue:5 Topics: Animals; Anions; Body Weight; Cecum; Hydroxyl Radical; Lipid Peroxidation; Liver; Mineral Oil; Nitri	2004
Low-dose dexamethasone ameliorates circulatory failure and renal dysfunction in conscious rats with endotoxemia. Shock (Augusta, Ga.), 2004, Volume: 21, Issue:5 Topics: Animals; Arteries; Blood Pressure; Blotting, Western; Calcium; Dexamethasone; Endotoxemia; Escherich	2004
Transduction of NO-bioactivity by the red blood cell in sepsis: novel mechanisms of vasodilation during acute inflammatory disease. Blood, 2004, Sep-01, Volume: 104, Issue:5 Topics: Acute Disease; Animals; Cecum; Disease Models, Animal; Erythrocytes; Hemoglobins; Ligation; Lipopoly	2004
Bicuculline methiodide attenuates hepatic injury and decreases mortality in septic rats: role of cytokines. Shock (Augusta, Ga.), 2004, Volume: 22, Issue:4 Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bicuculline; Bilirubin; Cytokines; GABA	2004
Ascorbate protects against impaired arteriolar constriction in sepsis by inhibiting inducible nitric oxide synthase expression. Free radical biology & medicine, 2004, Oct-15, Volume: 37, Issue:8 Topics: Angiotensin II; Animals; Arterioles; Ascorbic Acid; Blood Pressure; Cecum; Drug Administration Sched	2004
Effects of sesame oil on oxidative stress after the onset of sepsis in rats. Shock (Augusta, Ga.), 2004, Volume: 22, Issue:6 Topics: Administration, Oral; Animals; Catalase; Cecum; Glutathione; Lipid Peroxidation; Lipopolysaccharides	2004
Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo. The Journal of biological chemistry, 2005, Mar-18, Volume: 280, Issue:11 Topics: Animals; Aorta; Blood Pressure; Blotting, Western; Bone Marrow Cells; Cells, Cultured; Chromones; Cy	2005
Comparison of effects of nitric oxide synthase (NOS) inhibitors on plasma nitrite/nitrate levels and tissue NOS activity in septic organs. Microbiology and immunology, 2005, Volume: 49, Issue:2 Topics: Animals; Brain; Enzyme Inhibitors; Escherichia coli; Lipopolysaccharides; Lung; Male; Nitrates; Nitr	2005
Role of oxidative stress in the pathogenesis of septic ileus in mice. Neurogastroenterology and motility, 2005, Volume: 17, Issue:2 Topics: Aldehydes; Animals; Antioxidants; Catalase; Disease Models, Animal; Gastric Emptying; Gastrointestin	2005
Effects of glutamine supplementation on splenocyte cytokine mRNA expression in rats with septic peritonitis. World journal of gastroenterology, 2005, Mar-28, Volume: 11, Issue:12 Topics: Animal Feed; Animals; Cytokines; Glutamine; Lymphocytes; Male; Nitrates; Nitrites; Peritonitis; Rats	2005
Previous heat shock treatment attenuates lipopolysaccharide-induced hyporesponsiveness of platelets in rats. Shock (Augusta, Ga.), 2005, Volume: 24, Issue:3 Topics: Animals; Blood Platelets; Catalase; Dose-Response Relationship, Drug; Endotoxemia; Endotoxins; Hot T	2005
Effect of treatment on maxillary sinus and nasal nitric oxide concentrations in patients with nosocomial maxillary sinusitis. Chest, 2005, Volume: 128, Issue:3 Topics: Adult; Aged; Cross Infection; Device Removal; Drainage; Humans; Intubation, Gastrointestinal; Maxill	2005
Identification of an inducible nitric oxide synthase in diaphragm mitochondria from septic mice: its relation with mitochondrial dysfunction and prevention by melatonin. The international journal of biochemistry & cell biology, 2006, Volume: 38, Issue:2 Topics: Animals; Diaphragm; Electron Transport; Glutathione; Isoenzymes; Melatonin; Mice; Mice, Inbred C57BL	2006
Hemin prevents cardiac and diaphragm mitochondrial dysfunction in sepsis. Free radical biology & medicine, 2006, Jan-01, Volume: 40, Issue:1 Topics: Adenosine Triphosphate; Animals; Blood Pressure; Diaphragm; Endotoxins; Enzyme Inhibitors; Free Radi	2006
N-acetylcysteine protects the rats against phrenic nerve dysfunction in sepsis. Shock (Augusta, Ga.), 2006, Volume: 25, Issue:1 Topics: Acetylcysteine; Animals; Catalase; Electromyography; Malondialdehyde; Nitrates; Nitrites; Oxidation-	2006
Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure. Kidney international, 2006, Volume: 70, Issue:3 Topics: Acute Kidney Injury; Animals; Anti-Bacterial Agents; Biomarkers; Cecum; Cytokines; Disease Models, A	2006
Recombinant human activated protein C improves pulmonary function in ovine acute lung injury resulting from smoke inhalation and sepsis. Critical care medicine, 2006, Volume: 34, Issue:9 Topics: Airway Obstruction; Animals; Blood Pressure; Body Temperature; Disease Models, Animal; Female; Fibri	2006
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Role of nitric oxide in recombinant tumor necrosis factor-alpha-induced circulatory shock: a study in patients treated for cancer with isolated limb perfusion. Critical care medicine, 1996, Volume: 24, Issue:11 Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Chemotherapy, Cancer, Regional Perfusion	1996
The role of nitric oxide in experimental murine sepsis due to pyrogenic exotoxin A-producing Streptococcus pyogenes. Infection and immunity, 1997, Volume: 65, Issue:5 Topics: Animals; Cells, Cultured; Exotoxins; Immunohistochemistry; Interferon-gamma; Kidney; Kupffer Cells;	1997
Oxalated pyridoxalated hemoglobin polyoxyethylene conjugate normalizes the hyperdynamic circulation in septic sheep. Critical care medicine, 1997, Volume: 25, Issue:6 Topics: Animals; Blood Circulation; Blood Pressure; Blood Substitutes; Endothelin-1; Female; Hemoglobins; Ni	1997
Measurements of total plasma nitrite and nitrate in pediatric patients with the systemic inflammatory response syndrome. Critical care medicine, 1997, Volume: 25, Issue:6 Topics: Child, Preschool; Cohort Studies; Humans; Infant; Infant, Newborn; Nitrates; Nitrites; Predictive Va	1997
Effect of ciprofloxacin on the accumulation of interleukin-6, interleukin-8, and nitrite from a human endothelial cell model of sepsis. Critical care medicine, 1997, Volume: 25, Issue:8 Topics: Anti-Infective Agents; Cell Line; Ciprofloxacin; Drug Evaluation, Preclinical; Endothelium, Vascular	1997
The compensatory anti-inflammatory cytokine interleukin 10 response in pediatric sepsis-induced multiple organ failure. Chest, 1998, Volume: 113, Issue:6 Topics: Adolescent; Blood Cells; Cells, Cultured; Child; Child, Preschool; Humans; Infant; Infant, Newborn;	1998
Effects of nitric oxide synthase inhibition in lipopolysaccharide-induced sepsis in mice. Pharmacological research, 1998, Volume: 38, Issue:5 Topics: Animals; Econazole; Enzyme Inhibitors; Female; Guanidines; Lipopolysaccharides; Male; Mice; Nitric O	1998
Myocardial dysfunction in the septic rat heart: role of nitric oxide. Shock (Augusta, Ga.), 1998, Volume: 10, Issue:5 Topics: Animals; Coronary Circulation; Dexamethasone; Escherichia coli Infections; In Vitro Techniques; Isot	1998
Carnitine deprivation adversely affects cardiovascular response to bacterial endotoxin (LPS) in the anesthetized neonatal pig. Shock (Augusta, Ga.), 1998, Volume: 10, Issue:5 Topics: Anesthesia; Animals; Animals, Newborn; Blood Glucose; Blood Pressure; Cardiac Output; Cardiovascular	1998
Urinary nitrite excretion after prophylactic intravenous immunoglobulin in premature infants. Biology of the neonate, 2000, Volume: 77, Issue:2 Topics: Birth Weight; Creatinine; Gestational Age; Humans; Immunoglobulins, Intravenous; Infant, Newborn; In	2000
Specific inhibitors of inducible nitric oxide synthase: efficacy in a rodent model of sepsis. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1999, Volume: 48 Suppl 2 Topics: Animals; Cell Line; Disease Models, Animal; Enzyme Inhibitors; Humans; Lipopolysaccharides; Mice; Ni	1999
Upregulation of inducible nitric oxide synthase and nitric oxide occurs later than the onset of the hyperdynamic response during sepsis. Shock (Augusta, Ga.), 2000, Volume: 13, Issue:4 Topics: Animals; Cecum; Gene Expression Regulation, Enzymologic; Hemodynamics; Intestine, Small; Kidney; Liv	2000
Nitric oxide produced via neuronal NOS may impair vasodilatation in septic rat skeletal muscle. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 278, Issue:5 Topics: Acetylcholine; Animals; Arterioles; Enzyme Inhibitors; Lactic Acid; Male; Muscle, Skeletal; Necrosis	2000
Bioactive products of arginine in sepsis: tissue and plasma composition after LPS and iNOS blockade. American journal of physiology. Cell physiology, 2000, Volume: 278, Issue:6 Topics: Animals; Arginine; Blood Pressure; Enzyme Inhibitors; Escherichia coli; Gene Expression Regulation,	2000
Effect of hemodialysis on plasma nitric oxide levels. Artificial organs, 2000, Volume: 24, Issue:5 Topics: Colorimetry; Cyclic GMP; Female; Follow-Up Studies; Humans; Inflammation Mediators; Kidney Failure,	2000
Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:3 Topics: Animals; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-1; Lipopolysaccharides; Mice; N	2000
Antisense oligodeoxynucleotides to human inducible nitric oxide synthase selectively inhibit induced nitric oxide production by human vascular endothelial cells: an experimental study. The European journal of surgery = Acta chirurgica, 2000, Volume: 166, Issue:11 Topics: Cells, Cultured; Data Interpretation, Statistical; DNA Primers; DNA, Complementary; Endothelium, Vas	2000
Erythrocyte deformability is a nitric oxide-mediated factor in decreased capillary density during sepsis. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:6 Topics: Acute Disease; Animals; Blood Flow Velocity; Blood Pressure; Disease Models, Animal; Electron Spin R	2001
Presence of nitrotyrosine with minimal inducible nitric oxide synthase induction in lipopolysaccharide-treated pigs. Shock (Augusta, Ga.), 2001, Volume: 16, Issue:4 Topics: Animals; Blood Gas Analysis; Blotting, Western; Disease Models, Animal; Hemodynamics; Lipopolysaccha	2001
Bacterial peptidoglycan-associated lipoprotein is released into the bloodstream in gram-negative sepsis and causes inflammation and death in mice. The Journal of biological chemistry, 2002, Apr-19, Volume: 277, Issue:16 Topics: Animals; Bacterial Outer Membrane Proteins; Cytokines; Dose-Response Relationship, Drug; Escherichia	2002
The tissue factor and plasminogen activator inhibitor type-1 response in pediatric sepsis-induced multiple organ failure. Thrombosis and haemostasis, 2002, Volume: 87, Issue:2 Topics: Adolescent; Child; Child, Preschool; Cytokines; Endothelium, Vascular; Female; Fibrinolysis; Humans;	2002
Increased bone resorption in the critically ill: association with sepsis and increased nitric oxide production. Critical care medicine, 2002, Volume: 30, Issue:4 Topics: Adult; Aged; Amino Acids; Bone Resorption; Creatinine; Critical Illness; Female; Humans; Intensive C	2002
A rationale for the prophylactic use of monophosphoryl lipid A in sepsis and septic shock. Biochemical and biophysical research communications, 1992, Jan-15, Volume: 182, Issue:1 Topics: Animals; Cells, Cultured; Female; Interferon-gamma; Lipid A; Lipopolysaccharides; Macrophage Activat	1992

nitrites and Blood Poisoning